Leveraging the Intramural Research Program to Effect Foundational Progress in Neurodegenerative Disease
This is the annual G. Burroughs Mider Lecture. Speaker Andrew Singleton works on the genetic basis of neurological disorders including Parkinson's disease, Alzheimer ’ s disease, dystonia, ataxia, dementia with Lewy bodies, and amyotrophic lateral sclerosis (ALS). His team seeks to identify genetic variability that causes or contributes to disease and to use this knowledge to understand the underlying molecular processes. Most recently his work has expanded to the use of multimodal data in predicting disease. Dr. Singleton ’ s group discovered a number of genetic mutations that cause disease, including the alpha-synucl...
Source: Videocast - All Events - November 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Using Genetics to Unravel Amyotrophic Lateral Sclerosis (ALS) 2) Retroviral Elements in Pathophysiology and as Therapeutic Targets in Amyotrophic Lateral Sclerosis (ALS)
For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 9/1/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 17, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine: Autophagy: Mechanisms and Malfunctioning in Neurodegenerative Diseases
Demystifying Medicine Lecture Series
Autophagy is the body's natural way to clean out damaged cells. Yet defects across the various stages of autophagy appear to be a common link among neurodegenerative diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. Understanding the breakdown of autophagy processes may offer important insights into pathogenesis and therapy.
Dr. Cuervo is the Robert and Ren é e Belfer Chair for the Study of Neurodegenerative Diseases at Albert Einstein College of Medicine. Her lab has linked alterations in lysosomal protein degradation, a form of autophagy, with numerous neu...
Source: Videocast - All Events - April 5, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Sounds in Silence: How the Cochlea Promotes Refinement of Auditory Circuits before Hearing Onset
NIH Neuroscience Seminar Series
Robert Wenthold Memorial Lecture
Dr. Bergles lab is interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. Neurons transmit information at specialized synaptic junctions, points of contact where action potentials elicit the release of a chemical neurotransmitter. Neurotransmission at excitatory synapses involves the vesicular release of glutamate, diffusion and binding of glutamate to various receptors, and uptake of glutamate by transporters. Transporters are critical for ensuring that receptors are availab...
Source: Videocast - All Events - April 26, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Hiroshi Mitsumoto, MD, DSc - Assessing the Role of Recent Therapeutic Breakthroughs in the Treatment of Amyotrophic Lateral Sclerosis
Assessing the Role of Recent Therapeutic Breakthroughs in the Treatment of Amyotrophic Lateral Sclerosis (Source: Peerview CME/CE Video Podcast - Neurology International)
Source: Peerview CME/CE Video Podcast - Neurology International - October 19, 2018 Category: Neurology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
2018 Demystifying Medicine: Amyotrophic Lateral Sclerosis (Lou Gehrig ’ s Disease): are we making progress?
The Demystifying Medicine Lecture Series is designed to help bridge the gap between advances in biology and their applications to major human diseases. The lectures include presentations of patients, pathology, diagnosis, and therapy in the context of major diseases and current research. All clinicians, trainees including fellows, medical students, Ph.D. students, and other healthcare and research professionals are welcome to attend.For more information go tohttps://demystifyingmedicine.od.nih.govAir date: 3/27/2018 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Author video abstract: Bassile et al. Pulmonary Physical Therapy Techniques to Enhance Survival in Amyotrophic Lateral Sclerosis: A Systematic Review
No description available (Source: Journal of Neurologic Physical Therapy - Video)
Source: Journal of Neurologic Physical Therapy - Video - June 28, 2016 Category: Physiotherapy Source Type: video
Beyond DNA: Sequence variation in the RNA
NIH Director's Wednesday Afternoon Lecture
DNA is our genetic blueprint. Generally it is expected that RNA sequences are identical to the underlying DNA. However, there are exceptions to this one-to-one relationship, such as the A-to-G RNA editing mediated by ADAR proteins. The Cheung lab uncovered many more sites where RNA sequences differ from the underlying DNA, beyond those mediated by the known RNA-editing mechanisms. Dr. Cheung will describe their findings of RNA-DNA sequence Differences, RDDs, and how their study of juvenile amyotrophic lateral sclerosis is leading to an understanding of RD...
Source: Videocast - All Events - December 1, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Genomics of amyotrophic lateral sclerosis
Presented by: Bryan J. Traynor, MB, MD, PhD, MMSc, MRCPI, Senior Investigator and Chief of the Neuromuscular Diseases Research Section, NIA, NIHCategory: NIH Director's SeminarsAired date: 04/10/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - April 14, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Genomics of amyotrophic lateral sclerosis
NIH Director's Seminar Series
Amyotrophic lateral sclerosis (ALS; Lou Gehrig’s disease) is a fatal neurodegenerative disorder that leads to rapidly progressive paralysis and respiratory failure. ALS is the third most common neurodegenerative disease in the Western World, and there are currently no effective therapies. Frontotemporal dementia (FTD) is the most common form of dementia in the population under the age of 65. An overlap between these two clinically distinct neurological diseases has long been recognized, but the molecular basis of this intersection was unknown.
Recently, the Laboratory of Neurogenetics ...
Source: Videocast - All Events - March 16, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: Amyotrophic Lateral Sclerosis (ALS) in the Genomics Age: Facts, Uncertainties and the Way Forward
Presented by: (1) Camilo Toro, MD, Staff Clinician, Neurology, Undiagnosed Diseases Program, NHGRI, NIH and 2) Bryan Traynor, MD, PhD Senior Investigator and Chief, Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, NIA, NIH.Category: Clinical Center Grand RoundsAired date: 09/03/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - September 4, 2014 Category: Journals (General) Tags: Past Events Source Type: video
CC Grand Rounds: Amyotrophic Lateral Sclerosis (ALS) in the Genomics Age: Facts, Uncertainties and the Way Forward
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 9/3/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 4, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
