Research reveals how the most common ALS mutation dooms cells
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. The research suggests possible new approaches to diagnosis and treatment of the lethal disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 10, 2019 Category: International Medicine & Public Health Source Type: news
Biochemical switches identified that could be triggered to treat muscle, brain disorders
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells. Such buildup is central to the pathology of three related diseases: inclusion body myopathy (IBM), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 10, 2019 Category: International Medicine & Public Health Source Type: news
Researchers reveal novel therapeutic strategy for ALS
(Chinese Academy of Sciences Headquarters) Researchers from the Institute of Neuroscience and their collaborators revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 9, 2019 Category: International Medicine & Public Health Source Type: news
In the Loop: Sandra Murphy-Pak and the Xavier Project -- creating the future of living with ALS
Sandra Murphy-Pak is not taking?amyotrophic lateral sclerosis, or ALS, lying down. Far from it, in fact. As?we noted?this past January, she's not letting the disease stand in the way of?her life as an artist. She's also helping to create "better therapies, if not a cure,?for those diagnosed with ALS in the future" by continually donating [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 8, 2019 Category: Databases & Libraries Source Type: news
Blacks Live Longer, Not Necessarily Better, With ALS
FRIDAY, April 5, 2019 -- Black Americans with amyotrophic lateral sclerosis (ALS) tend to live longer than whites with the disease because blacks are more likely to have a procedure called a tracheostomy, a new study shows.
But that may not always... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 5, 2019 Category: General Medicine Source Type: news
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distin...
Source: ScienceNOW - April 3, 2019 Category: Science Authors: Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivova, Z., Saarenpää, S., Saiz-Castro, G., Cuevas, M., Watters, A., Lundeberg, J., Bonneau, R., Phatnani, H. Tags: Molecular Biology, Neuroscience reports Source Type: news
Lauren Sciences LLC wins AU$1 million grant award from FightMND
(Lauren Sciences LLC) Lauren Sciences LLC, the private New York biotechnology company developing transformative V-Smart ® Nanomedicines for brain diseases, today announced it was awarded an AU$1 million translational grant from FightMND. The FightMND grant will advance Lauren Sciences development of LAUR-301, its novel V-Smart ® Nanomedicine for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease, or motor neuron disease (MND). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2019 Category: International Medicine & Public Health Source Type: news
Transplanted bone marrow endothelial progenitor cells delay ALS disease progression
(University of South Florida (USF Innovation)) Transplanting human bone marrow-derived endothelial progenitor cells into mice mimicking symptoms of amyotrophic lateral sclerosis (ALS) helped more motor neurons survive and slowed disease progression by repairing damage to the blood-spinal cord barrier, University of South Florida researchers report. The new research, published recently in Scientific Reports, contributes to a growing body of work exploring cell therapy approaches to barrier repair in ALS and other neurodegenerative diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 2, 2019 Category: Biology Source Type: news
Nursing professor wins $6.575 million in grants to tackle musculoskeletal disease
(University of Texas at Arlington) Marco Brotto -- the George W. and Hazel M. Jay Professor in the college, and an internationally renowned scientist and an expert in bone, muscle physiology and sarcopenia -- recently obtained renewal for two grants, and funding for three new grants from the National Institutes of Health. These awards will further his work in tackling sarcopenia and osteoporosis, and support his new work on diabetic skeletal muscle disease and amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 15, 2019 Category: Biology Source Type: news
Playing Professional Soccer Linked to Increased ALS Risk Playing Professional Soccer Linked to Increased ALS Risk
Italian professional soccer players have a twofold increased risk for amyotrophic lateral sclerosis (ALS), and those who develop the disease do so at a relatively young age.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 4, 2019 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Are Soccer Pros at Higher Risk for ALS?
THURSDAY, Feb. 28, 2019 -- Professional soccer players may be vulnerable to amyotrophic lateral sclerosis (ALS), a new study suggests.
The Italian researchers also found that soccer players may develop the neurodegenerative disease at a much younger... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 28, 2019 Category: General Medicine Source Type: news
Footballers are FIVE times more likely to get the condition that killed Professor Stephen Hawking
Hawking died in 2018 of amyotrophic lateral sclerosis, a neurological disease. Italian researchers found that footballers could develop ALS 21 years earlier than average. (Source: the Mail online | Health)
Source: the Mail online | Health - February 28, 2019 Category: Consumer Health News Source Type: news
AAN: Professional Soccer Players Show Increased Risk for ALS
THURSDAY, Feb. 28, 2019 -- Professional soccer players may have an increased risk for amyotrophic lateral sclerosis (ALS), according to a study scheduled for presentation at the upcoming annual meeting of the American Academy of Neurology, to be... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 28, 2019 Category: Pharmaceuticals Source Type: news
Could medical marijuana help grandma and grandpa with their ailments?
Medical marijuana may bring relief to older people who have symptoms like pain, sleep disorders or anxiety due to chronic conditions including amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, spinal cord damage and multiple sclerosis, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. (Source: World Pharma News)
Source: World Pharma News - February 28, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Could medical marijuana help grandma and grandpa with their ailments?
(American Academy of Neurology) Medical marijuana may bring relief to older people who have symptoms like pain, sleep disorders or anxiety due to chronic conditions including amyotrophic lateral sclerosis, Parkinson's disease, neuropathy, spinal cord damage and multiple sclerosis, according to a preliminary study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4-10, 2019. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 28, 2019 Category: International Medicine & Public Health Source Type: news
