Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
Conditions: Amyotrophic Lateral Sclerosis; Pseudobulbar Affect Interventions: Other: Diffusion Kurtosis Imaging (DKI); Other: Resting State Magnetoencephalography Sponsors: Aalborg University Hospital; University of Aarhus Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 2, 2024 Category: Research Source Type: clinical trials
Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis Interventions: Drug: Nerve Growth Factor Sponsors: Beijing Tiantan Hospital; Beijing University of Chemical Technology; Beijing Healthunion Cardio-Cerebrovascular Disease Prevention and Treatment Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 30, 2024 Category: Research Source Type: clinical trials
Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS
Conditions: Amyotrophic Lateral Sclerosis Interventions: Drug: nL-CHCHD-001 Sponsors: n-Lorem Foundation; Mayo Clinic Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 30, 2024 Category: Research Source Type: clinical trials
ALS Phase II Study of NX210c
Conditions: Amyotrophic Lateral Sclerosis Interventions: Drug: NX210c; Drug: Placebo Sponsors: Axoltis Pharma; ACT4ALS network Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in ALS Amyotrophic Lateral Sclerosis
Conditions: Evaluation of the Efficacy and Safety of Deep Cervical Lymph Node-vein Bypass Surgery in Patients With Amyotrophic Lateral Sclerosis Interventions: Procedure: Deep cervical lymph node-vein bypass surgery Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Conditions: Amyotrophic Lateral Sclerosis (ALS); Mutation in the Superoxide Dismutase-1 (SOD1) Gene Interventions: Drug: ALN-SOD; Other: Diluent; Drug: Placebo (PB) Sponsors: Regeneron Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials
Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS)
Conditions: Amyotrophic Lateral Sclerosis Interventions: Procedure: human Neural Stem Cells (hNSC); Procedure: Saline (Placebo) Sponsors: Casa Sollievo della Sofferenza IRCCS; Ministry of Health, Italy Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials
Advances in Telephone-based Cognitive Screening Procedures
Conditions: Amyotrophic Lateral Sclerosis; Alzheimer ' s Disease; Lewy Body Dementia; Frontotemporal Degeneration; Cerebrovascular Disorders Interventions: Behavioral: Telephone-based neuropsychological assessment - ALS; Behavioral: Telephone-based neuropsychological assessment - AD, LBD, FTD and CVD; Behavioral: Telephone-based and in-person cognitive screening - NIs Sponsors: Istituto Auxologico Italiano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 29, 2024 Category: Research Source Type: clinical trials
Perception of Unpleasant Sensations During Study Procedures in ALS Patients
Conditions: Amyotrophic Lateral Sclerosis Interventions: Other: Interview Sponsors: Istituto Auxologico Italiano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2024 Category: Research Source Type: clinical trials
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease
Conditions: Motor Neuron Disease, Amyotrophic Lateral Sclerosis; Motor Neuron Disease Progressive Spinal Muscle Atrophy; Primary Lateral Sclerosis; Multiple Sclerosis; Postpoliomyelitis Syndrome Interventions: Procedure: 232 Electrode Electrophysiology (EEG-ECG-EMG-EXG) Sponsors: University of Dublin, Trinity College; Motor Neurone Disease Association, UK; Irish Research Council, IE; Health Research Board, IE; Research Motor Neurone, IE; Thierry Latran Foundation, FR; ALS Association, USA Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases
Conditions: Amyotrophic Lateral Sclerosis; Motor Neuron Disease Sponsors: Istituto Auxologico Italiano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis; Motor Neuron Disease Sponsors: Istituto Auxologico Italiano; Azienda Ospedaliera Citt à della Salute e della Scienza di Torino; Ospedale San Raffaele Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials
Digital Assessment of Speech and Fine Motor Control in ALS
Conditions: Amyotrophic Lateral Sclerosis; Primary Lateral Sclerosis; Progressive Muscular Atrophy Interventions: Behavioral: Digital Speech and Handwriting Assessment Sponsors: Milton S. Hershey Medical Center; BioSensics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials
MRG-001 in Patients With Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis; Lou Gehrig Disease; Motor Neuron Disease; Motor Neuron Atrophy Interventions: Drug: MRG-001 Sponsors: MedRegen LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials
Study in ALS With Abatacept & IL-2
Conditions: Amyotrophic Lateral Sclerosis Interventions: Drug: Abatacept Injection [Orencia] and Proleukin (aldesleukin) Sponsors: The Methodist Hospital Research Institute Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials
