Cancer Therapy-Associated Polyposis May Mimic CRC Predisposition
FRIDAY, Feb. 21, 2020 -- Childhood and young adulthood cancer (CYAC) therapy-associated polyposis (TAP) often has clinical features suggestive of at least one colorectal cancer (CRC) predisposition syndrome, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 21, 2020 Category: Pharmaceuticals Source Type: news

Botswana: Childhood Cancer Solution Exists
[Botswana Daily News] Gaborone -First Lady Neo Masisi has identified factors contributing to the annual death toll of child cancer patients in sub-Saharan Africa. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 21, 2020 Category: African Health Source Type: news

Therapy-Associated Polyposis May Mimic Hereditary CRC Symptoms in AYA Cancer Survivors
Therapy-associated polyposis was found to have similar features to various hereditary colorectal cancer symptoms, and recognition of it could have implications for cancer risk and screening among childhood and young adult cancer survivors. (Source: CancerNetwork)
Source: CancerNetwork - February 20, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Researchers identify novel potential combination therapy for childhood brain tumors
(Write Science Right) Brazilian researchers working in collaboration with Canadian scientists demonstrated that all medulloblastoma tumor subtypes express two stem cell markers: BMI1 and CD133. When they induced DNA chromatin relaxation, tumor cell viability was reduced with down-regulation of BMI1 and CD133. These anti-tumor effects could be potentiated by concurrent inhibition of MAPK/ERK signaling. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 20, 2020 Category: Cancer & Oncology Source Type: news

NIH Slated for 7 percent Budget Cut
The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020. The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors. The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - February 18, 2020 Category: Biology Authors: AIBS Source Type: news

Young cancer survivors have higher risk of severe health problems later
(Reuters Health) - People who survive cancer during childhood and early adulthood are more likely to experience severe, life-threatening health problems and die prematurely, a recent study suggests. (Source: Reuters: Health)
Source: Reuters: Health - February 17, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Combination drug therapy for childhood brain tumors shows promise in laboratory models
(Johns Hopkins Medicine) In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 17, 2020 Category: International Medicine & Public Health Source Type: news

1 in 3 child cancer survivors develop serious health problem later in life, study finds
Survivors of childhood cancer are at increased risk for severe health problems later in life compared to the general population, according to a study published Friday in the journal The Lancet Oncology. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 15, 2020 Category: Consumer Health News Source Type: news

The Lancet Oncology: Young cancer survivors face higher risk of severe health problems in later life than the general population, study suggests
(The Lancet) Cancer survivors who are diagnosed during adolescence or early adulthood (age 15-20 years) are at increased risk of premature death compared to the general population. They have an elevated risk of severe or life-threatening conditions compared to a sibling control group, according to an observational study of more than 10,000 cancer patients from 27 academic institutions in the USA and Canada, published in The Lancet Oncology journal on International Childhood Cancer Day (15 February). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

Researchers describe new condition involving numerous GI polyps in cancer survivors
(Dana-Farber Cancer Institute) Dana-Farber Cancer Institute researchers report newly discovered condition known as therapy-associated polyposis, or TAP in which childhood cancer survivors develop numerous colorectal growths called polyps. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Three young brothers are fighting the same rare childhood cancer
Three brothers, none of them older than 5, are battling the same type of rare childhood cancer. (Source: CNN.com - Health)
Source: CNN.com - Health - February 12, 2020 Category: Consumer Health News Source Type: news

Botswana: First Lady Hails Efforts to Tackle Childhood Cancer
[Botswana Daily News] Gaborone -First Lady, Ms Neo Masisi has pleaded with the local business community to join hands with government to promote, improve and change the landscape of the health sector in the country. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 4, 2020 Category: African Health Source Type: news

Childhood maltreatment as a risk factor for cancer: findings from a population-based survey of Canadian adults - Hovdestad WE, Shields M, Shaw A, Tonmyr L.
This study adds to existing evidence that CM may also be a risk factor for cancer. METHODS: Based on data from a sample of 9783 me... (Source: SafetyLit)
Source: SafetyLit - February 1, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Improved Long-Term QOL Observed for Pediatric Cancer Survivors as Treatments Evolve
Regardless of these improvements though, researchers noted that cancer survivors remain at risk for shorter lifespans, particularly when radiotherapy was utilized as a part of their childhood cancer treatment. (Source: CancerNetwork)
Source: CancerNetwork - January 30, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Identified a determinant protein for tumor progression and metastasis in Rhabdomyos
(IDIBELL-Bellvitge Biomedical Research Institute) LOXL2 increases the metastatic capacity of tumors from Rhabdomyoarcoma, a childhood cancer. The metastasic activity of LOXL2 is inside the cells and is independent of its classical function. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 29, 2020 Category: Cancer & Oncology Source Type: news

Car smoking ban cuts child exposure to cigarette smoke
2015 law has led to 72% fall in teenagers tobacco smoke exposure Related items fromOnMedica Passive smoking causes 1 in 100 deaths Childhood fitness leads to healthy lungs as adult Cancer mortality cut by a third in young people Smoking in cars with kids should be banned Labour promises GP investment boost (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 28, 2020 Category: UK Health Source Type: news

Fewer Childhood Cancer Survivors Getting Hit by Heart Troubles
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 17, 2020 Category: Cancer & Oncology Tags: Cardiology, Oncology, Pediatrics, News, Source Type: news

Fewer Childhood Cancer Survivors Getting Hit by Heart Troubles
FRIDAY, Jan. 17, 2020 -- Since the 1970s, serious heart disease among childhood cancer survivors had declined remarkably, a new study finds. The decline suggests that efforts to make cancer treatments, including radiation, less toxic are paying... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 17, 2020 Category: General Medicine Source Type: news

Fewer Childhood Cancer Survivors Getting Hit by Heart Troubles
Title: Fewer Childhood Cancer Survivors Getting Hit by Heart TroublesCategory: Health NewsCreated: 1/17/2020 12:00:00 AMLast Editorial Review: 1/17/2020 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - January 17, 2020 Category: Cardiology Source Type: news

Violence and adversity in early life can alter the brain
(American College of Neuropsychopharmacology) But social supports can reduce the negative effects of childhood stress. Childhood adversity is a significant problem in the US, particularly for children growing up in poverty. Those who experience poverty have a much higher risk of being exposed to violence and suffering from a lack of social support, which can have long-term consequences including higher rates of diabetes, cancer, and other diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 17, 2020 Category: International Medicine & Public Health Source Type: news

Coronary Artery Disease Risk Down in Survivors of Childhood Cancer
Risk for coronary artery disease significantly decreased for survivors with diagnosis in 80s, 90s versus 70s (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 16, 2020 Category: Cancer & Oncology Tags: Cardiology, Oncology, Pediatrics, Pharmacy, Radiology, Journal, Source Type: news

' First Signal' of Reduced Toxicity From Childhood Cancer Tx'First Signal' of Reduced Toxicity From Childhood Cancer Tx
Attempts to minimize long-term toxicity from the treatment of childhood cancers are paying off: a new study finds the'first signal'of a decrease in cardiac toxicity.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 16, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Coronary Artery Disease Risk Down in Survivors of Childhood Cancer
THURSDAY, Jan. 16, 2020 -- There has been a decrease in the risk for coronary artery disease among adult survivors of childhood cancer, according to a study published online Jan. 15 in The BMJ. Daniel A. Mulrooney, M.D., from St. Jude Children's... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 16, 2020 Category: Pharmaceuticals Source Type: news

Adult heart disease after childhood cancer now less likely
Efforts to cut toxicity of treatment credited for drop in heart disease risk in survivors of childhood cancer Related items fromOnMedica Only half of new cancer drugs extend or improve life Women treated for cancer have higher CHF risk in pregnancy Metformin doesn ’t help HbA1c in teens with type 1 diabetes US doctor says FDA should have withdrawn rosuvastatin Codeine not to be used for coughs and colds in children under 12 (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 16, 2020 Category: UK Health Source Type: news

Indian boy blinded by leukaemia which made his eyes bleed and pop out can now see again
Sagar Dorji was just four years old when childhood leukemia caused his eyes to become swollen, bloodshot and come out of their sockets. Three years on little Sagar is free from cancer and he can see. (Source: the Mail online | Health)
Source: the Mail online | Health - January 10, 2020 Category: Consumer Health News Source Type: news

Adult Survivors of Childhood Cancer Living Longer Adult Survivors of Childhood Cancer Living Longer
Adult survivors of childhood cancer who were diagnosed in the 1990s are expected to live longer than those diagnosed in the 1970s, likely as a result of evolving treatment approaches, according to a new simulation study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 9, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Smart algorithm finds possible future treatment for childhood cancer
(Uppsala University) Using a computer algorithm, scientists at Uppsala University have identified a promising new treatment for neuroblastoma. This form of cancer in children, which occurs in specialised nerve cells in the sympathetic nervous system, may be life-threatening. In the long term the discovery, described in the latest issue of the scientific journal Nature Communications, may result in a new form of treatment for children in whom the disease is severe or at an advanced stage. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: news

Survivors of Childhood Cancers at Risk for Shortened Life Span
THURSDAY, Jan. 2, 2020 -- Survivors of childhood cancer remain at risk for shorter life spans, especially when they receive radiotherapy, according to a study published online Jan. 2 in JAMA Oncology. Jennifer M. Yeh, Ph.D., from the Harvard Medical... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 2, 2020 Category: Pharmaceuticals Source Type: news

A Mixed Start for Immunotherapy in Childhood Cancers A Mixed Start for Immunotherapy in Childhood Cancers
KEYNOTE-051 establishes a recommended pediatric dose for pembrolizumab and shows encouraging antitumor activity in one cancer type, but it was less effective in multiple other malignancies.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 2, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Young Cancer Patients Fare Better on Private Insurance
MONDAY, Dec. 30, 2019 -- The odds of surviving childhood cancer may be influenced by the type of health insurance a young patient has, researchers say. In a new study, children and young adults covered by Medicaid or other government agencies were... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 30, 2019 Category: General Medicine Source Type: news

'Some beautiful things are happening': behind Jim Allison's quest to cure cancer
A new documentary profiles the Nobel-winning, harmonica-slinging scientist behind one of the biggest modern breakthroughs in cancer treatmentJim Allison doesn ’t quite fit the archetype of the studious, buttoned-up scientist: with a full beard and long hair, the most gravelly of Texas drawls and a history of ripping a harmonica on stage with Willie Nelson, Allison seems more like a longstanding Grateful Dead fan than game-changer in the quest to cure ca ncer.The music-loving, 71-year-old scientist, long a renegade in the field of cancer research, is perhaps an unlikely prism through which to view the world of cutting...
Source: Guardian Unlimited Science - December 24, 2019 Category: Science Authors: Adrian Horton Tags: Documentary films Science Source Type: news

Scientists discover a new mechanism in childhood kidney cancer
(Rockefeller University) A problem in reader proteins that identify which gene is up for expression may cause normal cells to turn malignant during development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 18, 2019 Category: International Medicine & Public Health Source Type: news

Babies Born From Frozen Embryos May Be At Higher Risk Of Childhood Cancer
4234663 BOSTON (CBS) – According to a new study published in JAMA, children conceived through IVF using frozen embryos may be at higher risk of developing cancer. Researchers looked at more than a million children born in Denmark between 1996 and 2012. They found that children born after frozen embryo transfer were at more than double the risk of developing childhood cancer, like leukemia, than babies born to fertile women. Babies born through other fertility treatments, like IVF using fresh embryos and treatment with clomiphene (Clomid), were not associated with an elevated cancer risk. It is important to remembe...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 11, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston Cancer Fertility IVF Source Type: news

Study links frozen embryo transfer to childhood cancer risk
Children born after the use of frozen embryo transfer were at higher risk of childhood cancer, according to a new study, but the risk remains low. (Source: CNN.com - Health)
Source: CNN.com - Health - December 11, 2019 Category: Consumer Health News Source Type: news

Study links frozen embryo transfer to higher childhood cancer risk
Children born after the use of frozen embryo transfer were at higher risk of childhood cancer, according to a new study, but the risk remains low. (Source: CNN.com - Health)
Source: CNN.com - Health - December 10, 2019 Category: Consumer Health News Source Type: news

Study links fertility treatment with slight increase in childhood cancer
A study found that children born following frozen embryo transfer were nearly three times more likely to be diagnosed with some form of cancer than those born to women who didn't use fertility treatment. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 10, 2019 Category: Consumer Health News Source Type: news

ERC awards € 2 million to research into late effects of childhood cancer treatment
(Princess Máxima Center for Pediatric Oncology) The European Research Council (ERC) has awarded a Consolidator grant to Ruben van Boxtel, PhD. He receives this prestigious grant to study late effects - in particular the development of second cancers - in children who were treated with chemotherapy. In the Princess M á xima Center for pediatric oncology in Utrecht, Van Boxtel has the opportunity to use unique patient material for his studies and longitudinally follow the children who are cured from cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 10, 2019 Category: Cancer & Oncology Source Type: news

How Does Gaucher Disease Present?
Discussion Gaucher disease (GD) was first described by Philippe Gaucher in 1882. It was the first lysosomal storage disease (LSD) described and is the comparison prototype for many variations and their treatment. There are about 50 LSD and more well-known ones include Fabry, Niemann-Pick and Pompe diseases. LSDs currently have more than 300 different enzymes or membrane proteins affected which cause central nervous system and visceral disease. Overall the frequency of LSDs in aggregate is 1:3000 – 7000 live births. GD has an estimated prevalence of 1:57,000 – 111,000. It is higher within the Ashkenazi Jewish po...
Source: PediatricEducation.org - December 9, 2019 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Root of childhood kidney cancer discovered
(Wellcome Trust Sanger Institute) A fundamental change in our understanding of the childhood kidney cancer Wilms' tumor is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators. By comparing genome sequences from normal kidney tissue and tumors, the team identified patches of normal-looking kidney tissue that in fact carried DNA changes that cause Wilms' tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 5, 2019 Category: Cancer & Oncology Source Type: news

Embryonal precursors of Wilms tumor
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hyper...
Source: ScienceNOW - December 5, 2019 Category: Science Authors: Coorens, T. H. H., Treger, T. D., Al-Saadi, R., Moore, L., Tran, M. G. B., Mitchell, T. J., Tugnait, S., Thevanesan, C., Young, M. D., Oliver, T. R. W., Oostveen, M., Collord, G., Tarpey, P. S., Cagan, A., Hooks, Y., Brougham, M., Reynolds, B. C., Barone, Tags: Development, Medicine, Diseases reports Source Type: news

Hair dye, chemical straighteners boost breast cancer risk
Women who use permanent hair dye and chemical hair straighteners have a higher...Read more on AuntMinnie.comRelated Reading: High-risk women should start breast screening earlier Childhood radiotherapy, chemo boost breast cancer risk Black women still at higher risk of breast cancer death Young women at risk of breast cancer need screening DDT exposure tied to breast cancer risk (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 4, 2019 Category: Radiology Source Type: news

How Alex's Lemonade Stand is helping cancer researchers access Big Data
A beta version of the Childhood Cancer Data Lab's data mining tool will soon make its debut. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 27, 2019 Category: Biotechnology Authors: John George Source Type: news

A step forward in the struggle against neuroblastoma, a type of childhood cancer
(University of Seville) A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2019 Category: Cancer & Oncology Source Type: news

Breakthrough in understanding common childhood cancer
(Newcastle University) Scientists studying one of the most common forms of childhood cancer have made an important breakthrough in understanding how the disease progresses. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 25, 2019 Category: International Medicine & Public Health Source Type: news

Road traffic pollution raises lung cancer risk
Campaigners call for urgent action to hit pollution reduction targets Related items fromOnMedica UK asbestos regulations slammed High pollution days send hundreds to hospital Hitting clean air targets would prevent 10,000 UK child asthma cases Traffic pollution linked to 'millions' of childhood asthma cases Cars should be banned from around schools (Source: OnMedica Latest News)
Source: OnMedica Latest News - November 25, 2019 Category: UK Health Source Type: news

Wolf orders study into health impact of hydraulic fracturing
The Wolf administration on Friday announced it would spend about $3 million for research studies into the health impacts of hydraulic fracturing and the cases of rare childhood cancer cases reported over the past decade in Washington and Westmoreland counties. The Pennsylvania Department of Health study will look into asthma, birth outcomes and other acute conditions in southwestern Pennsylvania to determine whether the findings of projects elsewhere can be replicated "and will greatly add to the… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 22, 2019 Category: Biotechnology Authors: Paul J. Gough Source Type: news

Scientists drug combo that may give some hope for lethal childhood brain cancer sufferers
After using computer algorithms to sour through 9,000 possible drug combinations, Stanfors scientists found a pair with potential for treating diffuse intrinsic glioma, a rare and lethal childhood cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 22, 2019 Category: Consumer Health News Source Type: news

Scientists find promising drug combination against lethal childhood brain cancers
Studies in cell and animal models reveal insights into cancer cells ’ vulnerability that could lead to new strategies against brain cancers. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - November 20, 2019 Category: American Health Source Type: news

How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - November 20, 2019 Category: Consumer Health News Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news

How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Science - November 20, 2019 Category: Science Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news