High-tech TOILETS could spread superbugs, study warns
Multidrug-resistant bacteria called Pseudomonas aeruginosa (MDRP) have been discovered on water jet nozzles on electric toilets in hospitals in Japan. (Source: the Mail online | Health)
Source: the Mail online | Health - July 12, 2021 Category: Consumer Health News Source Type: news

High-tech toilets could spread antibiotic-resistant superbugs in hospitals, Japanese study suggests
(European Society of Clinical Microbiology and Infectious Diseases) Water-jet nozzles in electric toilets--commonly used in Japan and other parts of Asia--may be reservoirs for multidrug-resistant Pseudomonas aeruginosa (MDRP) in hospitals, increasing the risk of dangerous germ transmission among patients, according to new research being presented at the European Congress of Clinical Microbiology& Infectious Diseases (ECCMID) held online this year. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 11, 2021 Category: International Medicine & Public Health Source Type: news

Johnson & Johnson Launches Network of Global Health Discovery Centers that Aim to Speed Up Science and Tackle Pandemic Threats
NEW BRUNSWICK, N.J., July 9, 2021 – Johnson & Johnson (the Company) today announced the launch of the J&J Centers for Global Health Discovery (J&J Centers), a new, global network of unique research partnerships that will leverage the institutional strengths of Johnson & Johnson and leading academic institutions to accelerate discovery research to address the world’s most pressing global health challenges. The first J&J Satellite Center for Global Health Discovery (Satellite Center) was launched at the London School of Hygiene & Tropical Medicine (LSHTM) at an event co-hosted by Johnson &...
Source: Johnson and Johnson - July 9, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Africa: WHO Releases New Global Lists of High-Burden Countries for TB, HIV-Associated TB and Drug-Resistant TB
[WHO] The World Health Organization (WHO) today released updated global lists of high burden countries for tuberculosis (TB), HIV-associated TB and multidrug/rifampicin-resistant TB (MDR/RR-TB). The new lists are for 2021-2025 and replace those previously used between 2016 and 2020. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - June 24, 2021 Category: Infectious Diseases Source Type: news

Is methicillin-resistant Staphylococcus aureus a common pathogen in ventilation-associated pneumonia?: The experience of a tertiary teaching hospital in Jordan
Abstract: Ventilator-associated pneumonia is a life threatening device related infection in intensive care units. Methicillin-resistant Staphylococcus aureus is considered a common contagious pathogen causing pneumonia and sepsis. To assess the prevalence of S aureus in comparison to other pathogens, and their antibacterial sensitivity profile in ventilator-associated pneumonia. Data regarding ventilator-associated pneumonia of adults admitted to the intensive care unit, at the Jordan University of Science and Technology Hospital, between 2012 and 2018 were extracted from the computerized system. Microorganisms and their s...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Rapid Spread and Control of MDR Bacteria in COVID-19 Units Rapid Spread and Control of MDR Bacteria in COVID-19 Units
What factors may contribute to the spread of multidrug-resistant infections among hospitalized COVID-19 patients, and which infection control practices are most effective?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 6, 2021 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Tailor-made therapy of multi-resistant tuberculosis
(German Center for Infection Research) The successful treatment of multidrug-resistant tuberculosis requires clarification in advance as to which antibiotics the pathogens are resistant to. Classic testing is very time-consuming and delays the start of therapy. Researchers from the Research Center Borstel and the DZIF have now prepared a catalogue of all mutations in the genome of tuberculosis bacteria and on the basis of a genome sequencing can quickly and cheaply predict which medicines are most effective for tuberculosis treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 3, 2021 Category: International Medicine & Public Health Source Type: news

Chlorhexidine bathing to prevent healthcare-associated vancomycin-resistant Enterococcus infections: A cluster quasi-experimental controlled study at intensive care units, Journal of the Formosan Medical Association
Conclusion: CHG bathing is a highly effective approach to prevent VRE-HAIs at ICUs, in the context of active VRE surveillance with contact isolation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Unintended consequences of infection prevention and control measures during COVID-19 pandemic, American Journal of Infection Control
The impact of a multimodal infection control strategy originally designed for containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs) was evaluated over a 7-month period across the largest healthcare system in Singapore. • During the COVID-19 pandemic, methicillin-resistant Staphylococcus aureus acquisition rates declined significantly, together with central-line-associated-bloodstream infection rates; likely due to increased compliance with standard precautions. • Enhanced infection control measures resulted in the unintended positive consequences of containing health care-associated re...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Africa: TB Testing in 2020 Dropped Drastically Due to Covid-19
[The Global Fund] On World Tuberculosis Day, new data shows the COVID-19 pandemic has had a devastating impact on the fight against another deadly airborne disease: tuberculosis. Global Fund surveys in 13 countries with the highest TB burden in the world reveal that 29% fewer people were tested for TB compared to 2019. Worse, in those same countries, there were 45% fewer people tested for multidrug-resistant TB -- one of the most frightening forms of antimicrobial resistance. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 25, 2021 Category: African Health Source Type: news

Africa: Drug-Resistant Tuberculosis Trial Ends Enrolment After Positive Initial Data
[MSF] London - A trial aiming to find a better treatment for multidrug-resistant tuberculosis (MDR-TB) has stopped enrolling patients early after its independent data safety and monitoring board indicated that the regimen being studied is superior to current care, and more patient data was extremely unlikely to change the trial's outcome. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - March 24, 2021 Category: Infectious Diseases Source Type: news

Johnson & Johnson Announces Five Initiatives to Help Find the ‘Missing Millions’ of Undiagnosed People Living with Tuberculosis
NEW BRUNSWICK, N.J., 24 March 2021 – In recognition of World Tuberculosis (TB) Day, Johnson & Johnson today announced a series of new commitments and collaborations in support of global efforts to find and deliver care to the millions of adults and children living with TB who have not yet been diagnosed. Successfully identifying these people, especially those living with multidrug-resistant TB (MDR-TB), remains one of the most significant obstacles in achieving the United Nations (UN) Sustainable Development Goal of ending TB by 2030. These initiatives—together with the Global Fund to Fight AIDS, Tuberculos...
Source: Johnson and Johnson - March 24, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Lenacapavir Effective in Multidrug Resistant HIV Lenacapavir Effective in Multidrug Resistant HIV
Some observers expressed skepticism, noting that reduced viral load may have resulted not from lenacapavir but a simultaneous switch to an optimized backbone regimen.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 12, 2021 Category: Consumer Health News Tags: HIV/AIDS News Source Type: news

Antibiotic-resistant strains of staph bacteria may be spreading between pigs raised in factory farms
(Johns Hopkins University Bloomberg School of Public Health) DNA sequencing of bacteria found in pigs and humans in rural eastern North Carolina, an area with concentrated industrial-scale pig-farming, suggests that multidrug-resistant Staphylococcus aureus strains are spreading between pigs, farmworkers, their families and community residents, and represents an emerging public health threat, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 5, 2021 Category: International Medicine & Public Health Source Type: news

Mouse study shows bacteriophage therapy could fight drug-resistant Klebsiella pneumoniae
(NIH/National Institute of Allergy and Infectious Diseases) Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or " phage therapy. " Scientists at the National Institutes of Health have used two different bacteriophage viruses individually and then together to successfully treat research mice infected with multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 23, 2021 Category: International Medicine & Public Health Source Type: news

Organization of antibiotic stewardship in Europe: the way to go, Wiener medizinische Wochenschrift 171(Suppl 1): 4-8
It is more than two decades ago that a European Union conference on " The Microbial Threat " hosted by the Danish Government in Copenhagen in September 1998 issued recommendations to encourage good practice in the use of antimicrobial agents and reduce inappropriate prescribing. Essential components of those recommendations were antimicrobial teams in hospitals and the use of feedback to prescribers as well as educational activities. Two decades later, important surveillance systems on both antimicrobial resistance as well as on antibiotic consumption are functioning at the European level and in most European cou...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Incidence of Multidrug Resistant Infections in Emergency Department Patients with Suspected Sepsis, The American journal of the medical sciences 360(6): 650-655
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

Whole-genome sequencing of multidrug-resistant bacteria cost saving for hospitals
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news

Ibalizumab cost effective for multidrug-resistant HIV-1 infection in USA?
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news

UToledo awarded Department of Defense funding to advance promising new chemotherapy
(University of Toledo) The project relies on a unique cell death pathway to overcome the multidrug resistance that often characterizes triple negative breast cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 25, 2021 Category: International Medicine & Public Health Source Type: news

Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus. Archives of microbiology 202(10): 2751-2760.
In conclusion, diclofenac can be used in combination with antibiotics as anti-virulence agent against MDR-MRSA which will enhance the ability of immune system to eradicate infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Resistant Infections in Emergency Department Patients with Suspected Sepsis. The American journal of the medical sciences 360(6): 650-655.
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Quick and sensitive identification of multidrug-resistant germs
(Swiss Nanoscience Institute, University of Basel) Researchers from the University of Basel have developed a sensitive testing system that allows the rapid and reliable detection of resistance in bacteria. The system is based on tiny, functionalized cantilevers that bend due to binding of sample material. In the analyses, the system was able to detect resistance in a sample quantity equivalent to 1-10 bacteria. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 7, 2020 Category: Biology Source Type: news

South Africa: Government Should Be Buying Its Pharmaceuticals Locally - - Especially Now
[Daily Maverick] Someone very special to me is ill with multidrug-resistant TB. As TB is the leading cause of death in South Africa, and a particularly unpleasant disease, this is a scary diagnosis. But she is young, receiving the best of care and will survive. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - November 25, 2020 Category: Infectious Diseases Source Type: news

The Difference Between Multidrug-Resistant TB MDR-TB and Extensively Drug-Resistant TB XDR-TB
Title: The Difference Between Multidrug-Resistant TB MDR-TB and Extensively Drug-Resistant TB XDR-TBCategory: Diseases and ConditionsCreated: 11/18/2020 12:00:00 AMLast Editorial Review: 11/18/2020 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - November 18, 2020 Category: Respiratory Medicine Source Type: news

Calcium bursts kill drug-resistant tumor cells
(American Chemical Society) Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS'Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2020 Category: International Medicine & Public Health Source Type: news

Researchers awarded over $11 million to study multi-drug resistant infection factors
(University of Texas Health Science Center at Houston) A study aimed at better understanding why some critically ill patients develop multidrug-resistant infections is underway by researchers at The University of Texas Health Science Center at Houston (UTHealth). The multi-institution study will enroll patients at Memorial Hermann Hospital-Texas Medical Center and The University of Texas MD Anderson Cancer Center. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 14, 2020 Category: Infectious Diseases Source Type: news

Sepsis in surgical inpatients: under-recognised but with significant consequences
Conclusion(s): Sepsis was under-documented, and barriers exist with use of the national sepsis screening form. Frailty, which is a sepsis risk factor, should be assessed pre-operatively to maximise prevention. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Multidrug Resistance Common in Hospitalized Adults With HIV in Malawi Multidrug Resistance Common in Hospitalized Adults With HIV in Malawi
HIV-1 multidrug resistance is common and is associated with increased mortality among adults hospitalized with HIV infection in Malawi, according to a new study.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - September 18, 2020 Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news

Identifying Facilities at Risk of Receiving MDRO Patients Identifying Facilities at Risk of Receiving MDRO Patients
A novel new tool may help identify which healthcare facilities are at risk of receiving patients infected with multidrug-resistant organisms.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 9, 2020 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Notes from the Field: Multidrug-Resistant Tuberculosis Among Workers at Two Food Processing Facilities - Ohio, 2018-2019
This report describes an investigation of three cases of multidrug-resistant tuberculosis that occurred at two food processing facilities in Ohio. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 13, 2020 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Multidrug-Resistant TB (MDR TB) Tuberculosis (TB) Source Type: news

Test accurately IDs people whose gonorrhea can be cured with simple oral antibiotic
A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.In research published in the peer-reviewed journal Clinical Infectious Diseases,a UCLA-led team found thatof106 subjectsthe test identified as having a strain ofgonorrhea called wild-type gyrA serine, all were cured with a single dose of oral ciprofloxacin. Though the test has been available for three years, this is the first time it has been systematicall...
Source: UCLA Newsroom: Health Sciences - August 12, 2020 Category: Universities & Medical Training Source Type: news

New generation of drugs show early efficacy against drug-resistant TB
(Harvard Medical School) New drug regimen for multidrug-resistant tuberculosis shows early effectiveness in 85 percent of patients in a cohort including many with serious comorbidities. The results suggest a global need for expanded access to two recently developed medicines, bedaquiline and delamanid. Study cohort included many people who would have been excluded from trials because of comorbidities, severity of disease or extent of drug resistance. Findings highlight the importance of innovative regimens to improve outcomes for patients with multidrug-resistant tuberculosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 12, 2020 Category: International Medicine & Public Health Source Type: news

Africa: TB Alliance Announces European Commission Authorisation of New Treatment for Highly Drug-Resistant Tuberculosis
[TB Alliance] PRETORIA (3 August 2020)--Pretomanid, a novel compound developed by the non-profit organization TB Alliance, has been granted a conditional marketing authorisation by the European Commission (EC) for treating highly drug-resistant forms of pulmonary tuberculosis (TB).[i] The new drug was authorised as part of a three-drug, six month, all-oral regimen for the treatment of adults with extensively drug-resistant TB (XDR-TB) or multidrug-resistant TB (MDR-TB) who are treatment-intolerant or non-responsive (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - August 4, 2020 Category: Infectious Diseases Source Type: news

Johnson & Johnson Reports 2020 Second-Quarter Results
New Brunswick, N.J. (July 16, 2020) – Johnson & Johnson (NYSE: JNJ) today announced results for second-quarter 2020. “Our second quarter results reflect the impact of COVID-19 and the enduring strength of our Pharmaceutical business, where we saw continued growth even in this environment,” said Alex Gorsky, Chairman and Chief Executive Officer. “Thanks to the tireless work of our colleagues around the world and our broad range of capabilities, we continue to successfully navigate the external landscape, and we remain focused on advancing the development of a vaccine to help address this pandemic...
Source: Johnson and Johnson - July 16, 2020 Category: Pharmaceuticals Source Type: news

Our Pets May Harbor Much More Than Coronavirus
While concern over SARS-CoV-2 in dogs and cats has captured attention, scientists have also been investigating whether pets can transmit multidrug-resistant bacteria to us. (Source: The Scientist)
Source: The Scientist - July 13, 2020 Category: Science Tags: Notebook Magazine Issue Source Type: news

Rukobia Approved for Patients With Multidrug-Resistant HIV
Title: Rukobia Approved for Patients With Multidrug-Resistant HIVCategory: Health NewsCreated: 7/7/2020 12:00:00 AMLast Editorial Review: 7/8/2020 12:00:00 AM (Source: MedicineNet HIV General)
Source: MedicineNet HIV General - July 8, 2020 Category: Infectious Diseases Source Type: news

Rukobia Approved for Patients With Multidrug-Resistant HIV
TUESDAY, July 7, 2020 -- A new type of antiretroviral medication, Rukobia (fostemsavir), has been approved for people with HIV who have not had success with other therapies, the U.S. Food and Drug Administration announced Thursday. Rukobia, 600 mg... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 7, 2020 Category: General Medicine Source Type: news

FDA OKs First-in-Class HIV Therapy for Patients With Few Options FDA OKs First-in-Class HIV Therapy for Patients With Few Options
Fostemsavir (Rukobia) is indicated for heavily treatment-experienced patients living with multidrug-resistant HIV infection.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - July 7, 2020 Category: Drugs & Pharmacology Tags: HIV/AIDS News Alert Source Type: news

Stop TB Partnership and Johnson & Johnson, with support from USAID and The Global Fund, Announce Price Reduction for SIRTURO ® (bedaquiline) for Treatment of Drug-Resistant Tuberculosis in Low- and Middle-Income Countries
GENEVA, SWITZERLAND, 6 JULY 2020 – The Stop TB Partnership and Johnson & Johnson – with support from the Global Fund to Fight AIDS, TB and Malaria, and the U.S. Agency for International Development (USAID) – today announced joint efforts to help enable low- and middle-income countries to rapidly scale up use of SIRTURO® (bedaquiline) 100mg tablets in support of new, recently-released World Health Organization (WHO) treatment guidelines. Effective immediately, Johnson & Johnson will make bedaquiline available to Stop TB Partnership’s Global Drug Facility (GDF) at a price of USD$340 per si...
Source: Johnson and Johnson - July 6, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

A novel mechanism of mitochondrial dysfunctions-triggered the calcium signalling-dependent fungal multidrug resistance
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2020 Category: Respiratory Medicine Authors: MeganB Source Type: news

Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: A randomized controlled trial
Conclusion(s): Empirical therapy with the high-dose meropenem presented comparable clinical outcomes to the standard-dose meropenem in sepsis and septic shock patients. Besides, subgroup analysis manifested superior microbiological cure rate in sepsis or septic shock patients admitted from ED. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

FDA Approves New Pediatric Formulation of Sirturo (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020— The Janssen Pharmaceutical Companies of Johnson& Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of Sirturo (bedaquiline).... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - May 27, 2020 Category: Drugs & Pharmacology Source Type: news

U.S. FDA Approves New Pediatric Formulation of SIRTURO ® (bedaquiline) as Part of Combination Therapy to Treat Children with Pulmonary Multidrug-Resistant Tuberculosis
NEW BRUNSWICK, NJ, May 27, 2020 — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for a new pediatric formulation of SIRTURO® (bedaquiline). SIRTURO® is now indicated for use as part of combination therapy in the treatment of adult and pediatric patients (5 years and older and weighing at least 15 kg) with pulmonary multidrug-resistant tuberculosis (MDR‑TB). In the U.S., the medicine should be reserved for use when an effective treatment regimen cannot otherwise be provided. This indication received acceler...
Source: Johnson and Johnson - May 27, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

FMT Helps Without Clearing Multidrug-Resistant Organisms FMT Helps Without Clearing Multidrug-Resistant Organisms
For seriously ill patients with multidrug-resistant organisms in their gastrointestinal tract, fecal microbiota transplant (FMT) might result in fewer and less severe infections, investigators report.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 20, 2020 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Antibiotic exposure can 'prime' single-resistant bacteria to become multidrug-resistant
(University of Washington) Researchers at the University of Washington and the University of Idaho report that, for a bacterial pathogen already resistant to an antibiotic, prolonged exposure to that antibiotic not only boosted its ability to retain its resistance gene, but also made the pathogen more readily pick up and maintain resistance to a second antibiotic and become a dangerous, multidrug-resistant strain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2020 Category: International Medicine & Public Health Source Type: news

Study suggests pets are not a major source of transmission of drug-resistant microbes to their owners
(European Society of Clinical Microbiology and Infectious Diseases) New research due to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) has identified genetically identical multidrug-resistant bacteria in humans and their pets, suggesting human-animal transfer is possible in this context. However only a small number of cases were found, suggesting this is not a major source of antibiotic-resistant infections in humans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2020 Category: International Medicine & Public Health Source Type: news

Study reveals raw-type dog foods as a major source of multidrug-resistant bacteria that could potentially colonize humans
(European Society of Clinical Microbiology and Infectious Diseases) New research due to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) reveals that raw-type dog foods contain high levels of multidrug-resistant bacteria, including those resistant to last-line antibiotics. The potential transfer of such bacteria between dogs and humans is an international public health risk. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2020 Category: International Medicine & Public Health Source Type: news

Cancer drug resistance study raises immune red flags
(Scripps Research Institute) Once a cancer patient's tumors develop resistance to chemotherapy, the prognosis can be poor. However, inhibiting a key gene involved in multidrug resistance, MDR1, has not improved outcomes. A new study offers a reason, revealing unintended downstream effects on immune system cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 17, 2020 Category: Biology Source Type: news