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Veni vidi vici: How natural killer cells conquer the superbug Klebsiella
(University of Vienna) Multidrug resistance of microbes poses a serious global threat to human health. Resistant strains of Klebsiella pneumoniae significantly reduce therapeutic options for the treatment of potentially fatal pneumonia or sepsis. Pavel Kovarik and his team now report new insights into how immune cells communicate at the site of infection and join forces in the fight against Klebsiella infections. Their results might be used for the development of alternatives to ineffective anti-microbial drugs. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 16, 2017 Category: Biology Source Type: news

Combined resistance to multiple antibiotics: A growing problem in the EU
(European Centre for Disease Prevention and Control (ECDC)) On the occasion of the 10th European Antibiotic Awareness Day, the European Centre for Disease Prevention and Control (ECDC) is releasing its latest EU-wide data on antibiotic resistance, as well as its guidance on prevention and control of carbapenem-resistant Enterobacteriaceae (CRE). In 2016, combined resistance to several antibiotic groups continued to increase for Escherichia coli and Acinetobacter species. This situation is of great concern as patients infected with these multidrug-resistant bacteria have very limited treatment options. (Source: EurekAlert! ...
Source: EurekAlert! - Infectious and Emerging Diseases - November 15, 2017 Category: Infectious Diseases Source Type: news

Cells to Society: Native American Heritage/ Endowment / Research News
This study evaluates treatment outcomes from a clinical cohort with task-sharing between a clinical nurse practitioner and a medical officer. The researchers examined opportunities to increase treatment rates for multidrug-resistant tuberculosis in South Africa.     Read more   Climate Change ...
Source: Johns Hopkins University and Health Systems Archive - November 9, 2017 Category: Nursing Source Type: news

Genomic history of the seventh pandemic of cholera in Africa
The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 Vibrio cholerae O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublin...
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Weill, F.-X., Domman, D., Njamkepo, E., Tarr, C., Rauzier, J., Fawal, N., Keddy, K. H., Salje, H., Moore, S., Mukhopadhyay, A. K., Bercion, R., Luquero, F. J., Ngandjio, A., Dosso, M., Monakhova, E., Garin, B., Bouchier, C., Pazzani, C., Mutreja, A., Grun Tags: Medicine, Diseases, Microbiology reports Source Type: news

Study outlines 'perfect storm' that led to Colombia's antibiotic resistance epidemic
(University of Texas Health Science Center at Houston) The nearly simultaneous emergence of a gene responsible for producing carbapenemases -- enzymes that kill the most powerful antibiotics used against life-threatening, multidrug-resistant bacterial infections -- coupled with the introduction of a bacterial clone that spread between patients created the 'perfect storm' that led to today's antibiotic resistance epidemic in Colombia. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 7, 2017 Category: Infectious Diseases Source Type: news

Global Tuberculosis Report 2017
World Health Organization. 10/30/2017 This 262-page annual report provides a comprehensive and up-to-date assessment of the tuberculosis (TB) epidemic, and of progress in prevention, diagnosis, and treatment of the disease at global, regional, and country levels. It discusses how TB is the main cause of deaths related to antimicrobial resistance. Multidrug-resistant TB (MDR-TB) remains a public health crisis and a health security threat. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - November 1, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Puppy Poop Infection Tally Rises to 67 People in 15 States
TUESDAY, Oct. 31, 2017 -- An outbreak of a potentially deadly bacteria linked to contaminated puppy poop has spread to 15 states, a new federal report shows. These multidrug-resistant Campylobacter infections have now sickened 67 people. In the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 31, 2017 Category: General Medicine Source Type: news

NARMS (National Antimicrobial Resistance Monitoring System) 2015 Integrated Report
U.S. Food and Drug Administration. 10/2017 This 14-page report marks the 20th year of the National Antimicrobial Resistance Monitoring System (NARMS), and focuses on antimicrobial resistance to drug classes that are most important to human medicine (generally, first- or second-line treatments), multidrug resistance, and specific co-resistance profiles of epidemiological importance. It reports on the large dataset on bacteria that NARMS generates from 14 distinct sources, and their resistances. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - October 24, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Novel therapies for multidrug-resistant bacteria
Scientists at the University of Surrey in collaboration with research partners at the University of Sheffield and University of Würzburg, Germany, have developed novel antimicrobials, which could be used to treat infections, caused by multidrug-resistant bacteria. During this innovative study published in PLOS One, researchers found that novel classes of compounds, (Source: World Pharma News)
Source: World Pharma News - October 23, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Novel therapies for multidrug-resistant bacteria
(University of Surrey) Scientists at the University of Surrey in collaboration with research partners at the University of Sheffield and University of W ü rzburg, Germany, have developed novel antimicrobials, which could be used to treat infections, caused by multidrug-resistant bacteria. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 23, 2017 Category: Infectious Diseases Source Type: news

Namibia:Multi-Drug Resistant TB Drugs' Side Effects Can Be Controlled
[New Era] Windhoek -A recent study titled 'Optimizing the safety of multidrug-resistant (MDR) tuberculosis therapy in Namibia', by Evans Sagwa, showed that side effects occur frequently in patients treated with current second-line anti-TB drugs. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - October 16, 2017 Category: Infectious Diseases Source Type: news

Governments Must Step Up Fight Against Drug-Resistant TB
People with multidrug-resistant tuberculosis need access to newer drugs that could be a lifeline.  Language English (Source: MSF News)
Source: MSF News - October 13, 2017 Category: International Medicine & Public Health Authors: Jess Brown Source Type: news

Governments Must Step Up the Use of Newer Drugs to Fight Multidrug-Resistant TB
Press releaseGovernments Must Step Up the Use of Newer Drugs to Fight Multidrug-Resistant TBOctober 13, 2017Guadalajara, Mexico,  October 13, 2017—People with drug-resistant tuberculosis (DR-TB) are still not receiving two newer tuberculosis  (TB) drugs, bedaquiline and delamanid, which have shown improved cure rates for the disease, said the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) at the48th Union World Conference on  Lung Health in Guadalajara, Mexico, where the  global TB community is meeting. (Source: MSF News)
Source: MSF News - October 13, 2017 Category: International Medicine & Public Health Authors: Jess Brown Source Type: news

Mechanism of multidrug resistance
Friday, October 13, 2017 - 09:36Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Multidrug-Resistant Campylobacter Outbreak Linked to Pet Store Puppies Reaches 12 States (FREE)
By Amy Orciari Herman Edited by Andr é Sofair, MD, MPH, and William E. Chavey, MD, MS A Campylobacter outbreak linked to pet store puppies has affected 55 people in 12 states, the CDC said in an advisory. … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 6, 2017 Category: Primary Care Source Type: news

The World Is Running Out of Much Needed New Antibiotics
Posters: Misuse of antibiotics and risks. Credit: WHOBy Baher KamalROME, Oct 4 2017 (IPS)The world is running out of new antibiotics to combat the growing threat of antimicrobial resistance, a new specialised report warns ahead of this year’s World Antibiotic Awareness Week, adding that most of the drugs currently in the clinical pipeline are modifications of existing classes of antibiotics and are only short-term solutions. The latest World Health Organization (WHO) report on this issue “Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, includi...
Source: IPS Inter Press Service - Health - October 4, 2017 Category: International Medicine & Public Health Authors: Baher Kamal Tags: Featured Global Headlines Health Human Rights TerraViva United Nations Source Type: news

Antibiotics, Cleaners May Spread Multidrug-Resistant MRSA in Home
(MedPage Today) -- Variety of risk factors included pet ownership, small household (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - September 22, 2017 Category: American Health Source Type: news

The world is running out of antibiotics, WHO says
Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process. (Source: CNN.com - Health)
Source: CNN.com - Health - September 19, 2017 Category: Consumer Health News Source Type: news

TB: Rapid Test for Multidrug Resistance Shows Promise TB: Rapid Test for Multidrug Resistance Shows Promise
Study results suggest a new rapid test for tuberculosis resistance to multiple drugs could help guide point-of-care treatment and prevent the spread of resistance.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 15, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

August ’s top stories: Cancer Research UK’s new oncology trial, Novartis’ malaria drug trial
Cancer Research UK initiated a trial of LY3143921 hydrate to treat patients with advanced solid tumours, and Novartis and MMV initiated a Phase IIb trial of KAF156 to treat multidrug-resistant malaria in Africa. Drugdevelopment-technology.com wraps u … (Source: Drug Development Technology)
Source: Drug Development Technology - September 7, 2017 Category: Pharmaceuticals Source Type: news

The Unexpected and Troubling Rise of Candida auris The Unexpected and Troubling Rise of Candida auris
Behaving like a multidrug-resistant microbe, C auris is spreading rapidly throughout the world, including in healthcare facilities in the United States.CDC Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 24, 2017 Category: Consumer Health News Tags: Infectious Diseases Commentary Source Type: news

Otsuka and Mylan Announce License Agreement to Commercialize Delamanid (Deltyba(TM)) for Multidrug-Resistant Tuberculosis (MDR-TB) in High-Burden Countries
TOKYO, HERTFORDSHIRE, England and PITTSBURGH, Aug. 24, 2017 -- (Healthcare Sales & Marketing Network) -- Otsuka Pharmaceutical Co. Ltd. (Otsuka) and Mylan N.V. (NASDAQ, TASE: MYL) have entered into a license agreement between their respective subsidiaries... Biopharmaceuticals, Licensing Mylan, Otsuka Pharmaceutical, Delamanid, Deltyba (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 24, 2017 Category: Pharmaceuticals Source Type: news

Novartis and MMV initiate Phase IIb trial of KAF156 for malaria in Africa
Novartis and Medicines for Malaria Venture (MMV) have initiated a Phase IIb clinical trial of KAF156 to treat multidrug-resistant malaria in Africa. (Source: Drug Development Technology)
Source: Drug Development Technology - August 21, 2017 Category: Pharmaceuticals Source Type: news

Novartis and Medicines for Malaria Venture launch patient trial in Africa for KAF156, a novel compound against multidrug-resistant malaria
Novartis and Medicines for Malaria Venture (MMV) have launched a patient trial for KAF156, a next-generation antimalarial compound with the potential to treat drug-resistant strains of the malaria parasite. The trial will test the efficacy of KAF156 in combination with a new, improved formulation of the existing antimalarial lumefantrine. (Source: World Pharma News)
Source: World Pharma News - August 21, 2017 Category: Pharmaceuticals Tags: Featured Novartis Business and Industry Source Type: news

‘Superbugs’ found in Brazil’s urban waters
Researchers discover several species of multidrug-resistant bacteria in lakes and rivers of major cities. (Source: SciDev.Net)
Source: SciDev.Net - August 15, 2017 Category: International Medicine & Public Health Source Type: news

Drug Resistant Tuberculosis on the Rise in Eastern Europe Drug Resistant Tuberculosis on the Rise in Eastern Europe
The rapid increase in the epidemic of multidrug-resistant tuberculosis in Eastern Europe is a multifactorial problem, and action is required on many fronts, researchers warn.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 31, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Drug-Resistant Tuberculosis on the Rise in Eastern Europe Drug-Resistant Tuberculosis on the Rise in Eastern Europe
The rapid increase in the epidemic of multidrug-resistant tuberculosis in Eastern Europe is a multifactorial problem, and action is required on many fronts, researchers warn.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 31, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

TSO3 files FDA app seeking duodenoscope indication for Sterizone VP4 sterilizer
TSO3 said today it filed a 510(k) application with the FDA as it seeks to clear its Sterizone VP4 sterilizer for the terminal sterilization of duodenoscopes used in endoscopic retrograde cholangio-pancreatography procedures. The company’s Sterizone VP4 is a low-temperature sterilization system which uses dual-sterilants of vaporized hydrogen peroxide and ozone for the terminal sterilization of heat and moisture sensitive medical devices. The system has a single pre-programmed cycle which can be used to sterilize a wide range of devices, the Quebec City-based company said. TSO3 said that if awarded, the approval would...
Source: Mass Device - July 20, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regulatory/Compliance Sterilization / Calibration TSO3 Source Type: news

Nigeria: Govt Adopts Who Guidelines for Multidrug Resistant TB
[Vanguard] The Federal Government has introduced a shorter treatment procedure for Multi-Drug Resistant (MDR) Tuberculosis treatment in Nigeria even as the first Extensively Drug-Resistant TB ward and MDR ward opened at the south west zone TB reference laboratory at the University College Hospital, UCH, Ibadan, Oyo State. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - July 6, 2017 Category: Infectious Diseases Source Type: news

Tanzania: Drug-Resistant TB Patients Hope for a Shorter Dose
[Citizen] The most common complain of the patients suffering from multidrug resistant tuberculosis (MDR-TB) is the time it takes to finish the medication dosage [the amount of medicine/drug that should be taken during a said period of time]. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - July 3, 2017 Category: Infectious Diseases Source Type: news

Scary, infectious SUPERBUG just spread to five more U.S. states, including some in the Midwest
(Natural News) A deadly, hard-to-spot “superbug” yeast is rapidly infiltrating American hospitals. In June 2016, the U.S. Centers for Disease Control and Prevention (CDC) warned clinics about the emergence of a new multidrug-resistant yeast strain called Candida auris. Two months later the first seven cases of a C. auris infection were recorded in the United... (Source: NaturalNews.com)
Source: NaturalNews.com - June 21, 2017 Category: Consumer Health News Source Type: news

Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis
This Meta-analysis (9,056,241 patient-days and 159 estimates of incidence ratios) found that antibiotic stewardship programmes reduced the incidence of infections and colonisation with multidrug-resistant bacteria and C difficile infections in hospital inpatients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 20, 2017 Category: Consumer Health News Source Type: news

Former Pfizer Scientist Is Resurrecting Projects To Solve The Multidrug Resistant Bacteria Problem
Despite this success, Dr. Dunne wasn ’t done with Pfizer and his former anti-infective portfolio. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 13, 2017 Category: Pharmaceuticals Authors: John LaMattina, Contributor Tags: NYSE:PFE NYSE:AGN Source Type: news

Antibiotic-Associated Adverse Events Common Antibiotic-Associated Adverse Events Common
As many as 20% of hospitalized patients prescribed antibiotics experienced an adverse drug event, including Clostridium difficile or multidrug-resistant organism infection, a new study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Transmission of Candida auris in US Health Care Facilities Transmission of Candida auris in US Health Care Facilities
This report details the epidemiology of the first seven U.S. cases of infection with the emerging, and often multidrug-resistant, fungus Candida auris.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 9, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

1 in 4 Nursing Home Residents Has Antibiotic-Resistant Bacteria
TUESDAY, May 30, 2017 -- Multidrug-resistant bacteria, such as E. coli, can be found in more than one-quarter of people living in nursing homes, a research review finds. Reviewing eight prior studies, researchers reported rates ranged from 11... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 30, 2017 Category: General Medicine Source Type: news

Spero Therapeutics Appoints Joel Sendek as Chief Financial Officer
Carol Waldo Also Joins Leadership Team as Head of Regulatory Affairs CAMBRIDGE, Mass., May 22, 2017 -- (Healthcare Sales & Marketing Network) -- Spero Therapeutics, LLC, a biopharmaceutical company founded to develop novel therapies for the treatment o... Biopharmaceuticals, Personnel Spero Therapeutics, multidrug resistant (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 22, 2017 Category: Pharmaceuticals Source Type: news

DOT Cuts Death During Multidrug Resistant TB Treatment
(MedPage Today) -- U.S. data analysis shows 77% reduction with directly observed therapy (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 21, 2017 Category: Primary Care Source Type: news

Directly observed therapy for multidrug-resistant TB decreases mortality
(American Thoracic Society) Directly observed therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in the United States, compared to self-administered therapy from 1993 to 2013, according to new research presented at the ATS 2017 International Conference. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 21, 2017 Category: Infectious Diseases Source Type: news

Superbug grows to 122 cases across 7 states
The number of cases of an emerging and often multidrug-resistant fungus in the United States has grown from seven to 122 over the past nine months, according to a field report in the Morbidity and Mortality Weekly Report issued Thursday by the US Centers for Disease Control and Prevention. (Source: CNN.com - Health)
Source: CNN.com - Health - May 19, 2017 Category: Consumer Health News Source Type: news

Superbug C. auris grows to 122 cases across 7 states, CDC says
The number of cases of an emerging and often multidrug-resistant fungus in the United States has grown from seven to 122 over the past nine months, according to a field report in the Morbidity and Mortality Weekly Report issued Thursday by the US Centers for Disease Control and Prevention. (Source: CNN.com - Health)
Source: CNN.com - Health - May 18, 2017 Category: Consumer Health News Source Type: news

Candida auris: Emerging, Frequently Resistant, and Often Deadly Candida auris: Emerging, Frequently Resistant, and Often Deadly
Given frequent multidrug resistance, what drug therapy is appropriate for treating Candida auris?Medscape Pharmacists (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 17, 2017 Category: Consumer Health News Tags: Pharmacist Ask the Expert Source Type: news

Multidrug - Resistant TB Set to Increase Through 2040
Increase in percentage of MDR tuberculosis, XDR tuberculosis in India, Philippines, Russia, S. Africa (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 11, 2017 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Nursing, Pathology, Pulmonology, Journal, Source Type: news

Sewage Saved This Man's Life. Someday It Could Save Yours.
When Thomas Patterson woke up from a two-month coma in March 2016, he learned two things he couldn’t believe: Donald Trump was soon to become the Republican nominee for president, and his wife, Steffanie Strathdee, had saved him from dying of an antibiotic-resistant superbug by injecting him with viruses harvested from sewage. It took a lot of convincing for him to accept these weren’t just more hallucinations. Patterson and Strathdee met while serving on a National Institutes of Health grant review panel almost 16 years ago. Strathdee doesn’t usually find review panels a riveting experience, but when she...
Source: Healthy Living - The Huffington Post - May 11, 2017 Category: Consumer Health News Source Type: news

Sewage Saved This Man's Life. Someday It Could Save Yours.
This article has been updated to amend overstatements of the length of time it took the Texas A&M team to secure the phages they sent to Patterson, as well as the number of researchers to whom Strathdee reached out. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - May 11, 2017 Category: Science Source Type: news

Enterococci may have evolved antimicrobial resistance millions of years ago
(NIH/National Institute of Allergy and Infectious Diseases) Enterococci bacteria are the bane of hospitals, causing thousands of multidrug-resistant infections in patients each year. Now, researchers have traced evidence of the bacteria's evolutionary history back 425 million years and theorize that the same traits that allow the bacteria to thrive in hospitals likely emerged when they were carried onto land in the guts of the world's first terrestrial animals. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 11, 2017 Category: Infectious Diseases Source Type: news

The Deadliest Form Of Tuberculosis Is Snowballing In Countries That Are Already Hard Hit
The deadliest forms of tuberculosis are worsening in four of the countries with the largest number of TB cases, according to a new report in the Lancet Infectious Diseases journal. While tuberculosis, when treated, has an over 83 percent cure rate on average globally, multidrug-resistant TB (MDR-TB), which is resistant to the standard TB antibiotic regimen, has about a 52 percent survival rate if treated. Extensively drug-resistant TB (XDR-TB) has a 28 percent survival rate when treated. Currently, almost 40 percent of all multidrug-resistant tuberculosis cases ― about 230,000 ― occur in Russia, India, t...
Source: Healthy Living - The Huffington Post - May 9, 2017 Category: Consumer Health News Source Type: news