Ibalizumab Active in Multidrug Resistant HIV-1 Infection
THURSDAY, Aug. 16, 2018 -- Ibalizumab has antiviral activity among patients with multidrug resistant (MDR) HIV-1 infection, according to a study published in the Aug. 16 issue of the New England Journal of Medicine. Brinda Emu, M.D., from the Yale... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 16, 2018 Category: Pharmaceuticals Source Type: news

A blend of Mexican mint and oregano oil can treat multidrug-resistant bacteria: Study
(Natural News) Researchers are now looking to the mint plant as a possible alternative treatment for multidrug-resistant bacteria, according to a study in BMC Complementary and Alternative Medicine. A collaboration of researchers from INTA College, the Federal Rural University of Rio de Janeiro, and the Federal University of Ceará in Brazil found that the essential oil of the Mexican... (Source: NaturalNews.com)
Source: NaturalNews.com - August 15, 2018 Category: Consumer Health News Source Type: news

Hospital superbugs developing ‘tolerance to alcohol disinfectants’
A multidrug-resistant bacterial species that can cause infections in hospitals is becoming increasingly tolerant to the alcohols used in handwash disinfectants, according to Australian researchers. (Source: Nursing Times)
Source: Nursing Times - August 2, 2018 Category: Nursing Source Type: news

Superbugs now also becoming resistant to alcohol disinfectants
Multidrug-resistant "superbugs" that can cause dangerous infections in hospitals are becoming increasingly resistant to alcohol-based hand sanitizers and disinfectants designed to hold them at bay, scientists said. (Source: Reuters: Health)
Source: Reuters: Health - August 1, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Hospital-associated bacterial species becoming tolerant to alcohol disinfectants
(American Association for the Advancement of Science) A multidrug-resistant bacterial species that can cause infections in hospitals is becoming increasingly tolerant to the alcohols used in handwash disinfectants, a new study finds. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 1, 2018 Category: Infectious Diseases Source Type: news

Is this the next superbug? Understanding drug-resistant candida and why antibiotics don't work
(Natural News) Move over, superbug: The next drug-resistant pathogen could be a fungus that already calls our body home. In a study published in The Journal of Infectious Diseases last year, researchers noted an uptick in reports of invasive Candida infections that are resistant to antifungal agents. The article, which discussed the current trends in multidrug resistance, revealed that... (Source: NaturalNews.com)
Source: NaturalNews.com - July 29, 2018 Category: Consumer Health News Source Type: news

Multidrug-Resistant Infections: What's on the Horizon? Multidrug-Resistant Infections: What's on the Horizon?
As resistance develops to'last-line'antimicrobials, what's next in the treatment of serious bacterial infections?Society for Healthcare Epidemiology of America (SHEA) (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 18, 2018 Category: Consumer Health News Tags: Infectious Diseases Viewpoint Source Type: news

Study: Herbal plants found to treat tuberculosis naturally
(Natural News) A major issue facing the medical community today is the rise of multidrug-resistant tuberculosis, which hampers current efforts to end the deadly disease globally. The World Health Organization (WHO) estimates that while the incidences of tuberculosis have been decreasing by around two percent each year, all effort must be made in exploring every... (Source: NaturalNews.com)
Source: NaturalNews.com - July 17, 2018 Category: Consumer Health News Source Type: news

Zemdri (plazomicin) Approved by FDA for the Treatment of Adults with Complicated Urinary Tract Infections (cUTI)
SOUTH SAN FRANCISCO, Calif., June 26, 2018 (GLOBE NEWSWIRE) -- Achaogen, Inc., a biopharmaceutical company developing and commercializing innovative antibacterial agents to address multidrug resistant (MDR) gram-negative infections, today announced... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - June 25, 2018 Category: Drugs & Pharmacology Source Type: news

South Africa:A New Revolution in TB Treatment as the Injection Falls
[MSF] South Africa has just made history today as it becomes the first country in the world to take a bold step of replacing an injectable drug with toxic side effects, with a promising new oral medicine (bedaquiline) in the standard multidrug-resistant tuberculosis (MDR-TB) treatment regimens for adolescents and adults. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - June 20, 2018 Category: Infectious Diseases Source Type: news

Plant-based antimicrobial compounds offer a variety of alternatives to an over-dependence on toxic synthetic antibiotics that are increasingly less effective
(Natural News) In the 20th century, synthetic antibiotics were considered to be the silver bullet for most medical conditions: It treated most diseases, reduced overall mortality, and extended a person’s lifespan. However, what was supposedly a gift has turned into one of the worst things to ever happen, with the rise of multidrug-resistant bacteria strains.... (Source: NaturalNews.com)
Source: NaturalNews.com - June 19, 2018 Category: Consumer Health News Source Type: news

Colistin-resistant multidrug-resistant bacteria pervasive in rural Vietnam town
(American Society for Microbiology) A new study has found that the majority of residents in a rural village of Vietnam harbored multi-drug-resistant (MDR), colistin-resistant E. coli bacteria. Colistin is typically used as a last-resort treatment when there are no other therapy options available. The research is presented at ASM Microbe, the annual meeting of the American Society for Microbiology, held from June 7-11 in Atlanta, Ga. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 9, 2018 Category: International Medicine & Public Health Source Type: news

Containment of Novel MDR Organisms and Resistance Mechanisms Containment of Novel MDR Organisms and Resistance Mechanisms
How has CDC's approach to detection, identification, containment, and surveillance evolved in the face of the changing landscape of multidrug-resistant organisms?Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 27, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

' Alarming' New Numbers on Bacterial Infection in Cirrhosis'Alarming' New Numbers on Bacterial Infection in Cirrhosis
One-third of infections in cirrhotic patients around the world are caused by multidrug-resistant organisms, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 12, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Many Cirrhosis Patients Harbor Multidrug-Resistant Bugs (CME/CE)
(MedPage Today) -- 18% of North Americans with infections; three-quarters of those in India (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 12, 2018 Category: American Health Source Type: news

Even short travel can spread colistin-resistant bacteria
(Osaka University) The use of the antibiotic colistin, a last-resort treatment option in the infection by multidrug-resistant bacteria, is increasingly impeded by colistin-resistant bacteria. Japanese researchers used biochemical and genetic assays to track resistant strains of bacteria in Japanese travelers returning from Vietnam. The researchers found short trips to a developing country can lead to the appearance of the colistin-resistance gene mcr-1. The study highlights that even brief international trips can contribute to the spread of colistin resistance. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 10, 2018 Category: Infectious Diseases Source Type: news

Vital Signs: Containment of Novel Multidrug-Resistant Organisms and Resistance Mechanisms — United States, 2006–2017
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - April 3, 2018 Category: American Health Source Type: news

Vital Signs: Containment of Novel Multidrug-Resistant Organisms and Resistance Mechanisms - United States, 2006-2017
Infection data from the National Healthcare Safety Network from 2006-2015 were analyzed to calculate changes in the annual proportion of selected pathogens that were nonsusceptible to extended-spectrum cephalosporins (ESBL phenotype) or resistant to carbapenems (carbapenem-resistant Enterobacteriaceae [CRE]). (Source: HSR Information Central)
Source: HSR Information Central - April 3, 2018 Category: International Medicine & Public Health Source Type: news

Monthly News Roundup - March 2018
FDA OKs First-In-Class HIV Drug Trogarzo for Drug Resistant HIV The FDA has approved a novel HIV agent for patients who have multidrug-resistant HIV (MDR HIV-1) and have failed other therapies. Trogarzo (ibalizumab-uiyk) from TaiMed Biologics is... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 31, 2018 Category: Pharmaceuticals Source Type: news

UK man has first case of super-resistant gonorrhea
Public Health England is investigating the case of a UK man infected with a multidrug-resistant form of gonorrhea. (Source: CNN.com - Health)
Source: CNN.com - Health - March 28, 2018 Category: Consumer Health News Source Type: news

UK man has world's first case of super-resistant gonorrhea
Public Health England is investigating the case of a UK man infected with a multidrug-resistant form of gonorrhea. (Source: CNN.com - Health)
Source: CNN.com - Health - March 28, 2018 Category: Consumer Health News Source Type: news

First case of super-resistant gonorrhea reported
Public Health England is investigating the case of a UK man infected with a multidrug-resistant form of gonorrhea. (Source: CNN.com - Health)
Source: CNN.com - Health - March 28, 2018 Category: Consumer Health News Source Type: news

New York City Has Biggest Tuberculosis Spike in 26 Years New York City Has Biggest Tuberculosis Spike in 26 Years
Cases rose 10% to 613 in 2017, the first increase since 2003. Fourteen of the patients had multidrug-resistant TB. Though no specific cause was cited, the health department laments budget cuts.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 27, 2018 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

When TB Treatment is Toxic
VideoWhen TB Treatment is ToxicMarch 23, 2018Khumbulani, 16, has multidrug-resistant tuberculosis (MDR-TB). In 2017, he lost his hearing. In early 2018, his eyesight faded. The side effects were not from the disease, but from Khumbulani's treatment. Better drugs for resistant strains of TB exist, but too few people have access to them. It's time to #StepUpForTB (Source: MSF News)
Source: MSF News - March 23, 2018 Category: International Medicine & Public Health Authors: Melissa Pracht Source Type: news

For patients with drug-resistant infections, infectious diseases experts may be lifesaving
(Infectious Diseases Society of America) Researchers analyzed records for approximately 4,200 patients with infections resistant to multiple antibiotics from 2006 to 2015 at one academic medical center. Thirty-day mortality rates were about 50 percent lower among patients with certain multidrug-resistant infections who had infectious diseases (ID) specialists involved in their care. Among patients with Enterobacteriaceae infections resistant to several antibiotics, an ID consultation was associated with a 59 percent reduction in 30-day mortality. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 23, 2018 Category: Infectious Diseases Source Type: news

NIH scientists describe potential antibody approach for treating multidrug-resistant Klebsiella pneumoniae
Promising concept may lead to an alternative to antibiotics. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - March 13, 2018 Category: American Health Source Type: news

NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
(NIH/National Institute of Allergy and Infectious Diseases) Researchers are developing a promising alternative to antibiotic treatment for infections caused by Klebsiella pneumoniae bacteria resistant to carbapenem antibiotics. The approach uses antibodies to target the K. pneumoniae protective capsule polysaccharide, allowing immune system cells called neutrophils to attack and kill the bacteria. The early stage, in vitro research was conducted by scientists at NIAID's Rocky Mountain Laboratories and the New Jersey Medical School-Rutgers University. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 13, 2018 Category: Infectious Diseases Source Type: news

FDA Approves Ibalizumab for Multidrug-Resistant HIV-1 FDA Approves Ibalizumab for Multidrug-Resistant HIV-1
The FDA has approved ibalizumab-uiyk (Trogarzo, Theratechnologies Inc) for the treatment of adults with multidrug-resistant HIV-1.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 6, 2018 Category: Consumer Health News Tags: HIV/AIDS News Alert Source Type: news

FDA Approves Trogarzo (ibalizumab-uiyk) for Treatment-Experienced Patients with Multidrug Resistant HIV
March 6, 2018 -- Today, the U.S. Food and Drug Administration approved Trogarzo (ibalizumab-uiyk), a new type of antiretroviral medication for adult patients living with HIV who have tried multiple HIV medications in the past (heavily... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 6, 2018 Category: Drugs & Pharmacology Source Type: news

Tetraphase Pharmaceuticals Announces FDA Acceptance for Filing of its NDA Submission for Eravacycline for the Treatment of Complicated Intra-Abdominal Infections
WATERTOWN, Mass., Feb. 27, 2018 (GLOBE NEWSWIRE) -- Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a biopharmaceutical company focused on developing and commercializing novel antibiotics to treat life-threatening multidrug-resistant (MDR)... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - February 27, 2018 Category: Drugs & Pharmacology Source Type: news

A path to multidrug resistance
(Source: ScienceNOW)
Source: ScienceNOW - February 22, 2018 Category: Science Authors: Vinson, V. Tags: Biochemistry, Medicine, Diseases twis Source Type: news

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
The multidrug transporter permeability (P)–glycoprotein is an adenosine triphosphate (ATP)–binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein extrudes toxic molecules and drugs from cells through ATP-powered conformational changes. Despite decades of effort, only the structures of the inward-facing conformation of P-glycoprotein are available. Here we present the structure of human P-glycoprotein in the outward-facing conformation, determined by cryo–electron microscopy at 3.4-angstrom resolution. The two nucleotide-binding domains form a closed dimer occluding t...
Source: ScienceNOW - February 22, 2018 Category: Science Authors: Kim, Y., Chen, J. Tags: Biochemistry, Medicine, Diseases reports Source Type: news

In soil-dwelling bacteria, scientists find a new weapon to fight drug-resistant superbugs
It ’s a new class of antibiotic that promises to live up to its rough Latin translation: killer of bad guys.In a reportpublished this week in the journal Nature Microbiology, researchers describe a never-before-seen antibiotic agent that vanquished several strains of multidrug-resistant bacteria.... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - February 13, 2018 Category: Science Authors: Melissa Healy Source Type: news

Multidrug-resistant Malaria Outbreak Originated in Western Cambodia Multidrug-resistant Malaria Outbreak Originated in Western Cambodia
The current outbreak of multidrug-resistant malaria in Southeast Asia originated in western Cambodia soon after dihydroartemisinin-piperaquine became the first-line antimalarial drug there, according to a new genetic study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 8, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Re-introducing an 'old' antibiotic may help fight multi-drug resistant bacteria
(Wiley) A new study indicates that the drug fosfomycin may be effective for treating multidrug-resistant bacterial infections. In most European countries, the oral formulation is only approved as a 3 gram single dose for the treatment of uncomplicated cystitis; however the Pharmacology Research& Perspectives study found that a dosing regimen of 6-12 grams per day divided in 3 doses is required for the treatment of systemic multi-drug-resistant bacterial infections. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 7, 2018 Category: International Medicine & Public Health Source Type: news

Malaria-Causing Parasite Mutating to Resist Multiple Drugs
FRIDAY, Feb. 2, 2018 -- An outbreak of multidrug-resistant malaria in southeast Asia likely stems from two mutations of the malaria-causing parasite that combined a decade ago, according to new research. The parasite and mutations, carried by... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 2, 2018 Category: General Medicine Source Type: news

Reducing Antibiotic Use in Respiratory Syncytial Virus: A Quality Improvement Approach to Antimicrobial Stewardship
This research article examines how increased incidence of multidrug-resistant organisms is associated with increased morbidity, mortality, hospital length of stay, and cost. Estimates show that up to 50% of antimicrobial use is inappropriate. This initiative focuses on inappropriate use of antibiotics in respiratory syncytial virus (RSV) infections. This virus is the most common cause of bronchiolitis during childhood. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 25, 2018 Category: Consumer Health News Source Type: news

Emerging Multidrug-Resistant Candida Species Emerging Multidrug-Resistant Candida Species
Infections caused by multidrug-resistant Candida species are on the rise. How are these infections best treated?Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria
The Society for Healthcare Epidemiology of America addresses when hospitals can safely stop protocols in the wake of multidrug-resistant infections and Clostridium difficile infections.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 12, 2018 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes. We performed a genome analysis of 262 Plasmodium falciparum parasites resistant to 37 diverse compounds. We found 159 gene amplifications and 148 nonsynonymous changes in 83 genes associated with drug-resistance acquisition, where gene amplifications contributed to one-third of resistance acquisition events. Beyond confirming previously identified multidrug-resistance mechanisms, we discovered hitherto unrecognized drug target–inhibitor pairs, including thymidy...
Source: ScienceNOW - January 11, 2018 Category: Science Authors: Cowell, A. N., Istvan, E. S., Lukens, A. K., Gomez-Lorenzo, M. G., Vanaerschot, M., Sakata-Kato, T., Flannery, E. L., Magistrado, P., Owen, E., Abraham, M., LaMonte, G., Painter, H. J., Williams, R. M., Franco, V., Linares, M., Arriaga, I., Bopp, S., Core Tags: Genetics, Microbiology r-articles Source Type: news

Cluster of resistant tuberculosis pathogen discovered
(University of Zurich) Between February and Nov. 2016, the Institute of Medical Microbiology at the University of Zurich discovered a multidrug-resistant Mycobacterium tuberculosis in eight refugees arriving in Europe from the Horn of Africa. The analyses provided an impulse for launching a transnational investigation and developing a pan-European alerting system. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 9, 2018 Category: Biology Source Type: news

Research paves the way for treatment strategies of multidrug-resistant chronic infections
(Technical University of Denmark) A new study published in Cell Press finds that antibiotic treatment of chronic infections can be optimized by targeting vulnerabilities of antibiotic-resistant pathogens paving the way for more effective treatment strategies. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 5, 2018 Category: Infectious Diseases Source Type: news

Tetraphase Pharmaceuticals Announces Submission of New Drug Application to FDA for Eravacycline for the Treatment of Complicated Intra-Abdominal Infections (cIAI)
WATERTOWN, Mass., Jan. 02, 2018 (GLOBE NEWSWIRE) -- Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a clinical stage biopharmaceutical company developing novel antibiotics to treat life-threatening multidrug-resistant (MDR) infections, today... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - January 2, 2018 Category: Drugs & Pharmacology Source Type: news

Bedaquiline and Delamanid Treatment in Drug-Resistant TB Bedaquiline and Delamanid Treatment in Drug-Resistant TB
Combination therapy with bedaquiline and delamanid may be another option for patients with multidrug-resistant tuberculosis and limited treatment options.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 18, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Medical News Today: Metformin may prevent multidrug-resistant breast cancer
Type 2 diabetes drug metformin has been found to inhibit and reverse the development of multidrug resistance in vitro in breast cancer cells. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 7, 2017 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Diabetes drug metformin inhibits multidrug-resistant breast cancer
(PLOS) The drug metformin, typically prescribed to treat type 2 diabetes, keeps breast cancer cells from developing multiple drug resistance (MDR) and can reverse MDR after it ¹ s appeared, according to a study published Dec. 6, 2017 in the open-access journal PLOS ONE by Terra Arnason from the University of Saskatchewan, Canada, and colleagues. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 6, 2017 Category: Cancer & Oncology Source Type: news

Action Needed to Avoid the End of Modern Medicine
This study influenced the development of the WHO’s new  guidelines, which are aimed at influencing policy makers in the agriculture and health sectors.   According to a WHO press release, the guidelines include:An overall reduction in the use of all classes of medically important antibiotics in food-producing animals.Complete restriction of these antibiotics for growth promotion and for disease prevention without diagnosis.Healthy animals should only receive antibiotics to prevent disease if it has been diagnosed in other animals in the same flock or herd or fish population.Antibiotics used in animals ...
Source: IPS Inter Press Service - Health - December 5, 2017 Category: International Medicine & Public Health Authors: Martin Khor Tags: Development & Aid Global Governance Headlines Health Poverty & SDGs TerraViva United Nations Source Type: news

When Medicines Don ’t Work Anymore
Credit: BigstockBy Martin KhorPENANG, Malaysia, Dec 4 2017 (IPS)The growing crisis of antibiotic resistance is catching the attention of policy makers, but not at a rate enough to tackle it.More diseases are affected by resistance, meaning the bacteria cannot be killed even if different drugs are used on some patients, who then succumb.We are staring at a future in which antibiotics don’t work, and many of us or our children will not be saved from TB, cholera, deadly forms of dysentery, and germs contracted during surgery.Martin Khor, Executive Director of the South Centre, a think tank for developing countries, base...
Source: IPS Inter Press Service - Health - December 4, 2017 Category: International Medicine & Public Health Authors: Martin Khor Tags: Development & Aid Global Global Governance Headlines Health Poverty & SDGs Regional Categories TerraViva United Nations Source Type: news

Use of Bedaquiline in Children With Multidrug-Resistant TB Use of Bedaquiline in Children With Multidrug-Resistant TB
Should bedaquiline be considered as another safe and effective treatment option for multidrug-resistant tuberculosis in children?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 4, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news