Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epigenetic Mutations Accumulate with Age, with Uncertain Consequences https://www.fightaging.org/archives/2019/12/epigenetic-mutations-accumulate-with-age-with-uncertain-consequences/ Epigenetic markers, such as methylation, determine the production rates of specific proteins in a cell. These epigenetic decorations to DNA change constantly, but many changes are characteristic of aging, which has led to the generation of epigenetic clocks in recent years. Epigenetic mutations are distinct from these changes, being effectively a form of stochastic damage in which methylation is inappropriately applied to a given location in the genome. Does this cause significant issues in aging? That is an open question, and can be considered in a similar way to the question of the effects of mutation to nuclear DNA. In most cases, random methylation won't have much of an...
Prevalences, nuances of presentation, and likely clinical course of myocarditis after use of some vaccines against SARS-CoV-2 are in sharper view after additions to the literature this week.Medscape Medical News
Immune checkpoint inhibitors can be effective in patients with non-small cell lung cancer and mild interstitial lung disease, but with a greater risk.Medscape Medical News
AbstractPurposeGenetic variants may influence the pharmacokinetics and pharmacodynamics (PKPD) of cyclophosphamide (CY). CY plays a critical role in conditioning chemotherapy for hematopoietic cell transplantation (HCT), but its use is limited by toxicity. We explored the effect of genetic variants, potentially affecting PKPD of CY, and outcomes after HCT.MethodsThis observational pharmacogenomic study included 85 adults with hematologic malignancies who received reduced intensity conditioning with CY, fludarabine, and total body irradiation. We collected recipient DNA prior to HCT and evaluated 97 candidate variants in 66...
Oncogene, Published online: 27 January 2022; doi:10.1038/s41388-021-02158-wSELENOF is a new tumor suppressor in breast cancer
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00651-zMalignant hypertension and atypical hemolytic uremic syndrome: a possible continuum between two entities?
Journal of Human Hypertension, Published online: 27 January 2022; doi:10.1038/s41371-021-00652-yFocus on today’s evidence while keeping an eye on the future: lessons derived from hypertension in women
A Warren County startup is planning to significantly grow its capital stack with a planned eight-figure fundraise later this year, and officials are hoping to ring in some Midwest dollars this time around to combat increasing pressures to move the company ’s headquarters to a bigger biotech hub. Amplicore, a Mason-based early-stage biopharma startup developing a new pipeline of drugs to treat musculoskeletal disorders like osteoarthritis, is looking to raise a $30 million Series A by summer. The…
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT04315C, PaperXiang Wang, Kang Song, Yong Deng, Jie Liu, Qin Peng, Xiao Lao, Jiayu Xu, Dong Wang, Turong Shi, Yuhao Li, Dan Deng, Yuqing Miao Photodynamic therapy (PDT) is an effective non-invasive treatment for tumors. The structure of the photosensitizer has an important influence on the light utilization and the efficiency of singlet-oxygen generation. In... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC06330H, CommunicationXiao-Jie Dong, Wen-Yan Li, Qun Guan, Yan-An Li, Yu-Bin Dong A COF-based multifunctional nanomedicine CuS@COF-BDP, which can be used as a PTT/PDT bimodal therapeutic agent to inhibit cancer cell proliferation under visible- and NIR-II-light irradiation, is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC05792H, CommunicationElena Atri án-Blasco, Lucie de Cremoux, Xudong Lin, Rufus Mitchell-Heggs, Laurent Sabater, Sébastien Blanchard, Christelle Hureau Keggin-type POMs extract Cu(II) from the Alzheimer's-related amyloid- β peptide. They prevent Cu(Aβ) ROS production, while ill-defined Cu(Aβ) aggregates are switched to fibrils due to Cu(POM) modulation of the apo-Aβ's assembly. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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