Fight Aging! Newsletter, December 23rd 2019
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epigenetic Mutations Accumulate with Age, with Uncertain Consequences https://www.fightaging.org/archives/2019/12/epigenetic-mutations-accumulate-with-age-with-uncertain-consequences/ Epigenetic markers, such as methylation, determine the production rates of specific proteins in a cell. These epigenetic decorations to DNA change constantly, but many changes are characteristic of aging, which has led to the generation of epigenetic clocks in recent years. Epigenetic mutations are distinct from these changes, being effectively a form of stochastic damage in which methylation is inappropriately applied to a given location in the genome. Does this cause significant issues in aging? That is an open question, and can be considered in a similar way to the question of the effects of mutation to nuclear DNA. In most cases, random methylation won't have much of an...
Authors: Hwang S, Ren T, Gao B Abstract Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy drinking on steatohepatitis and discuss the underlying mechanisms obtained from the study of several mouse models. High-fat diet (HFD) feeding and binge ethanol synergistically induced steatohepatitis and fibrosis in mice with significant intrahepatic neutrophil infiltration; such HFD-plus-ethanol treatment markedly up-regulat...
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
CONCLUSION: To ensure patient satisfaction and high quality of life, an accurate diagnosis for vertigo or dizziness is required; therefore, methods or materials to improve the diagnostic accuracy are needed. PMID: 32940200 [PubMed - as supplied by publisher]
Publication date: November 2020Source: Research in Developmental Disabilities, Volume 106Author(s): Franceli L. Cibrian, Melisa Madrigal, Marina Avelais, Monica Tentori
CONCLUSION: Our study expands the mutation spectrum of WSF1 mutations with three novel mutations. Homozygosity mapping may provide enrichment for molecular genetic analysis and early diagnosis of WS1 patients with incomplete phenotype, particularly in consanguineous pedigrees. PMID: 32938580 [PubMed - as supplied by publisher]
Publication date: Available online 17 September 2020Source: Stem Cell ResearchAuthor(s): Huifang Zhao, Lang He, Hualin Huang, Shuai Li, Na Cheng, Feng Tang, Xiaobo Han, Zuoxian Lin, Rongqi Huang, Peng Zhou, Sihao Deng, Jufang Huang, Zhiyuan Li
Publication date: Available online 17 September 2020Source: Stem Cell ReportsAuthor(s): Andrejs Ivanovs, Stanislav Rybtsov, Richard A. Anderson, Alexander Medvinsky
Publication date: Available online 17 September 2020Source: Stem Cell ReportsAuthor(s): Dominic C.H. Ng, Dominic K. Richards, Richard J. Mills, Uda Y. Ho, Hannah L. Perks, Callum R. Tucker, Holly K. Voges, Julia K. Pagan, James E. Hudson
Publication date: December 2020Source: Nano Today, Volume 35Author(s): Tanziela Tanziela, Sana Shaikh, Hui Jiang, Zuhong Lu, Xuemei Wang
Publication date: Available online 18 September 2020Source: Progress in Natural Science: Materials InternationalAuthor(s): Zonghua Liu, Linghong Huang, Wei Xue
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