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Gliknik commences dosing in Phase II oral cavity cancer trial
US-based biopharmaceutical firm Gliknik has commenced patient dosing in a Phase II clinical trial of immunomodulatory therapeutic biropepimut-S (GL-0817) to prevent recurrence of oral cavity squamous cell cancer. (Source: Drug Development Technology)
Source: Drug Development Technology - August 29, 2017 Category: Pharmaceuticals Source Type: news

Increased Node Dissection Improved Survival in Node-Negative Oral Cavity SCC
Higher nodal yield during definitive surgery for clinically node-negative oral cavity squamous cell carcinoma was associated with improved mortality. (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Head & Neck Cancer News Source Type: news

Higher Nodal Yield Tied to Lower Mortality in Oral Cavity Cancer
>24 nodes linked to longer overall survival in clinically node - negative patients (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 14, 2017 Category: Cancer & Oncology Tags: Oncology, ENT, Pathology, Surgery, Journal, Source Type: news

Surgery, Radiation Improve Survival in Some Oral Cancer Patients Surgery, Radiation Improve Survival in Some Oral Cancer Patients
Surgery and radiotherapy may be a better course than organ preservation with concurrent chemoradiotherapy in selected patients with oral cavity squamous cell cancer, according to Illinois-based researchers.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - April 28, 2017 Category: Radiology Tags: Hematology-Oncology News Source Type: news

Surgery Plus RT Improves Survival Over Chemo Plus RT in Oral Cavity Carcinoma
Surgery followed by postoperative radiotherapy was associated with prolonged overall survival compared with concurrent chemoradiotherapy in patients with locally advanced oral cavity squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - April 20, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Head & Neck Cancer News Source Type: news

Cancer Facts and Figures: Death Rate Down 25% Since 1991
By Stacy Simon The death rate from cancer in the US has declined steadily over the past 2 decades, according to annual statistics reporting from the American Cancer Society. The cancer death rate for men and women combined fell 25% from its peak in 1991 to 2014, the most recent year for which data are available. This decline translates to more than 2.1 million deaths averted during this time period. “Cancer Statistics, 2017,” published in the American Cancer Society’s journal CA: A Cancer Journal for Clinicians, estimates the numbers of new cancer cases and deaths expected in the US this year. The estimat...
Source: American Cancer Society :: News and Features - January 5, 2017 Category: Cancer & Oncology Tags: General Information Source Type: news

Genetic variants are associated with susceptibility to mouth and throat cancer
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) A number of genetic variants associated with susceptibility to oral cavity and pharyngeal cancer have been described in an international study published in Nature Genetics and coordinated by the International Agency for Research on Cancer and involved 40 research groups in Europe, the United States, and South America. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 15, 2016 Category: Cancer & Oncology Source Type: news

CDC: 40% of Cancer Cases in US Might Be Linked to Tobacco
By Stacy Simon New data from the Centers for Disease Control and Prevention (CDC) show that 40% of cancers diagnosed in the US may have a link to tobacco use. The report was published in the November 11, 2016 issue of Vital Signs. Tobacco use is the leading preventable cause of cancer and cancer deaths. It can cause cancer of the liver, colon and rectum, lung, oral cavity, esophagus, pharynx (throat), larynx (voice box), stomach, pancreas, bladder, kidney, and cervix, and acute myeloid leukemia. According to the CDC, about 660,000 people in the US were diagnosed each year between 2009 and 2013 with a cancer related to toba...
Source: American Cancer Society :: News and Features - November 11, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news

[Perspective] How tobacco smoke changes the (epi)genome
Worldwide, more than 1 billion people are tobacco smokers. Cigarette smoking drastically increases the risk of lung cancer. However, many other cancer types also occur more frequently in smokers than in nonsmokers, including cancers of the oral cavity, larynx, pharynx, esophagus, liver, cervix, pancreas, bladder, and kidney. Genome sequencing efforts are beginning to provide more sophisticated clues as to the processes at work that are shaping the mutational landscape of tumors. On page 618 of this issue, Alexandrov et al. (1) focused specifically on smoking-associated cancers and dissected genetic and epigenetic differenc...
Source: ScienceNOW - November 3, 2016 Category: Science Authors: Gerd P. Pfeifer Tags: Cancer Source Type: news

Navidea reels in $1m in Lymphoseek milestone payments
Navidea (NYSE:NAVB) said today it is set to receive $1 million from 2 milestone payments for its Lymphoseek injection designed for lymph nodes detection. The milestone payments come from from its U.S. distribution partner Cardinal Health (NYSE:CAH) and European partner SpePharm AG, the Dublin, Ohio-based company said. The payment from Cardinal Health is based on the sale of its 100,000th dose of Lymphoseek since launch, while the payment from SpePharm AB comes due to a positive opinion from the European Medicines Agency’sCommittee for Medicinal Products for Human Use for a 50 microgram kit for radiopha...
Source: Mass Device - September 22, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Oncology Cardinal Health Navidea Biopharmaceuticals Source Type: news

Cardinal Health to pay up to $310m for Navidea ’ s LymphoSeek
Navidea (NYSE:NAVB) said today it inked a letter of intent with Cardinal Health (NYSE:CAH) to sell its Lymphoseek injection for up to $310 million. The sale includes all current FDA-approved indications, as well as future oncology diagnostic indications in North America and other related assets, Dublin, Ohio-based Navidea said. Through the deal, Navidea is slated to receive $80 million upon closing, with future considerations tied to annual sales of Lymphoseek and sales-based milestones. “This is a significant announcement for all of us at Navidea. This agreement with Cardinal Health will provide signi...
Source: Mass Device - September 6, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Diagnostics Mergers & Acquisitions Oncology Cardinal Health Navidea Biopharmaceuticals Source Type: news

Elective Neck Dissection Cost Effective in Early Oral Cavity Cancer Elective Neck Dissection Cost Effective in Early Oral Cavity Cancer
Elective neck dissection (END) improves health outcomes and reduces costs in patients with early-stage oral cavity cancer, according to a cost-effectiveness analysis.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 29, 2016 Category: Surgery Tags: Hematology-Oncology News Source Type: news

5 Things You Don't Know About A Dentist
A dentist is simply a doctor in charge of your oral hygiene. So, let me ask you a question: How many times have you visited a dentist this year? Alright, you don't have to tell me your answer. Most people don't visit a dentist until they have severe problems in their oral area. I am also part of this group even if I don't want to admit it. This is because most people are unaware of the importance and usefulness of a dentist. It is recommended that you visit a dentist at least twice in a year to keep your gums and teeth healthy. Dental visits are supposed to start at the age of 8 years when the permanent teeth are repl...
Source: Healthy Living - The Huffington Post - August 22, 2016 Category: Consumer Health News Source Type: news

FDA Approves Keytruda (Pembrolizumab) for Head and Neck Cancer
By Stacy SimonThe US Food and Drug Administration (FDA) has approved Keytruda (pembrolizumab) to treat people with head and neck squamous cell carcinoma that has spread or come back after previous chemotherapy treatment. It’s the first immunotherapy drug approved for head and neck cancer. Keytruda is already approved for melanoma and non-small cell lung cancer.The FDA based its approval on a clinical trial of 174 people with head and neck squamous cell carcinoma that had spread or come back after they were treated with platinum-based chemotherapy. Tumors shrank or disappeared in 16% of the participants who were given...
Source: American Cancer Society :: News and Features - August 9, 2016 Category: Cancer & Oncology Tags: Oral Cavity and Oropharyngeal Cancer Source Type: news

American Cancer Society Updates HPV Vaccine Recommendations to Include Males
By Stacy Simon The American Cancer Society has updated its guideline for human papilloma virus (HPV) vaccination to include males. The change makes the guideline largely consistent with US government recommendations. The Advisory Committee on Immunization Practices (ACIP), part of the US Centers for Disease Control and Prevention (CDC), is the main source for US immunization policy. HPV VACCINE RESOURCES: Facts and Fears Recommendations by Age Detailed Information Almost everyone who is not vaccinated will get HPV at some time in their lives, and most will never know it. HPV is transmitted through sexual contact. The...
Source: American Cancer Society :: News and Features - July 19, 2016 Category: Cancer & Oncology Tags: Prevention/Early Detection Cervical Cancer Oral Cavity and Oropharyngeal Cancer Source Type: news

Light alcohol consumption tied to increased risk of breast cancer in women
(NaturalNews) In 1987, a working group of the International Agency for Research on Cancer (IARC) – an agency of the World Health Organization (WHO) – listed cancers of the oral cavity, pharynx, larynx, esophagus and liver as "causally related to the consumption of alcoholic... (Source: NaturalNews.com)
Source: NaturalNews.com - June 27, 2016 Category: Consumer Health News Source Type: news

Do These Four Things to Cut Your Cancer Risk
This study found that overall, 20% to 40% of carcinoma cases and about half of carcinoma deaths could potentially be prevented through certain lifestyle modifications. Here are the 4 lifestyle behaviors that if practiced throughout a lifetime, were found to be linked to a lower rate of cancer incidence and death: 1. Don't smoke The study revealed that smoking contributed to 48.5% of deaths from the 12 smoking-related cancers in the United States including lung, pancreas, bladder, stomach, colon/rectal and esophagus. The message here is plain and simple -- don't ever start smoking and if you already are, quit. Smoking ...
Source: Healthy Living - The Huffington Post - May 27, 2016 Category: Consumer Health News Source Type: news

To Predict and to Intercept
Disease interception – as opposed to the treatment of disease when it is diagnosed – has the potential to do two major things: to make things a great deal cheaper for cash-strapped health authorities and to offer patients a far better quality of life. In February 2015, Janssen launched its Disease Interception Accelerator (DIA), an ambitious platform which seeks to shift healthcare from diagnosis and treatment to prediction and pre-emption. In Janssen’s ideal world, the term ‘patient’ will become redundant, as intervening and stopping disease from progressing in healthy individuals becomes the...
Source: EyeForPharma - May 10, 2016 Category: Pharmaceuticals Authors: Adam Hill Source Type: news

ACS Releases Long-term Care Guideline for Survivors of Head and Neck Cancer
By Stacy Simon The American Cancer Society has released a new Head and Neck Survivorship Care Guideline to help survivors of head and neck cancer and their primary care providers better manage their long-term care. The guideline addresses cancers of the oral cavity, tongue, lip, pharynx (throat), and larynx (voice box). Recommendations in the guideline may also apply to cancers of the salivary glands, nasal and paranasal sinuses, and nasopharynx. But it does not address cancers of the brain, thyroid, or esophagus because they are very different in terms of symptoms and treatment. RESOURCES: Head and Neck Cancer Survivor...
Source: American Cancer Society :: News and Features - March 23, 2016 Category: Cancer & Oncology Tags: Oral Cavity and Oropharyngeal Cancer Laryngeal and Hypopharyngeal Cancer Salivary Gland Cancer Nasal Cavity and Paranasal Sinus Cancer Nasopharyngeal Cancer Source Type: news

Cancer Centers Urge More People to Get the HPV Vaccine
By Stacy Simon The American Cancer Society is supporting a call-to-action from dozens of National Cancer Institute-designated Cancer Centers across the US urging action to increase vaccination against human papillomavirus (HPV). HPV vaccines protect against high-risk types of the virus that cause most cervical cancers. The virus is also linked to cancers of the vulva, vagina, penis, anus, and throat. Despite this, vaccination rates across the US remain low. According to the Centers for Disease Control and Prevention (CDC), only 40% of girls and 21% of boys in the US have received all 3 doses of the vaccine. The CDC recomme...
Source: American Cancer Society :: News and Features - January 27, 2016 Category: Cancer & Oncology Tags: Cervical Cancer Oral Cavity and Oropharyngeal Cancer Anal Cancer Vulvar Cancer Vaginal Cancer Source Type: news

Study examines associations of HPV types, risk of head and neck
(The JAMA Network Journals) A new study suggests detection of human papillomavirus (HPV)-16 in the oral cavity was associated with 22-times increased risk of oropharyngeal squamous cell carcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 21, 2016 Category: Cancer & Oncology Source Type: news

What are Medicare costs for patients with oral cavity, pharyngeal cancers?
(The JAMA Network Journals) Medicare costs for older patients with oral cavity and pharyngeal cancers increased based on demographics, co-existing illnesses and treatment selection, according to a report published online by JAMA Otolaryngology-Head & Neck Surgery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 4, 2015 Category: Cancer & Oncology Source Type: news

Doctors at Mumbai's Tata Memorial Hospital find way to reduce risk of oral cancer
The innovation is an 'extra cut' - a dissection in medical parlance - along the neck to detect if the patient's cancer had spread from his/her oral cavity to the neck. (Source: The Economic Times)
Source: The Economic Times - June 3, 2015 Category: Consumer Health News Source Type: news

Study examines treatment factors associated with oral cavity cancer survival
(The JAMA Network Journals) The surgical procedure known as neck dissection to remove lymph nodes and receiving treatment at academic or research institutions was associated with improved survival in patients with stages I and II oral cavity squamous cell cancer, according to a report published online by JAMA Otolaryngology-Head & Neck Surgery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 14, 2015 Category: Cancer & Oncology Source Type: news

Researchers ID potential prognostic marker for recurrence of head and neck squamous cell carcinoma
(Elsevier Health Sciences) A new study provides the first evidence that the mediator complex subunit 15 (MED15) may play a crucial role in the pathophysiology of head and neck squamous cell carcinoma (HNSCC). MED15 overexpression was found to be associated with higher mortality rates in HNSCC patients with cancer recurrence, particularly in oral cavity/oropharyngeal tumors, according to the study published in the American Journal of Pathology. MED15 overexpression was also associated with heavy alcohol consumption, which is an HNSCC risk factor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2015 Category: Cancer & Oncology Source Type: news

Study by UCLA scientists reveals new findings about cause of lesions around jaw bone
This study was highlighted in “This Month in AJP” in the November issue and featured as the Editor’s Choice article, which is available to the science community.  This paper was also designated for journal-based Continuing Medical Education activity sponsored by Accreditation Council for Continuing Medical Education, as well as the American Society of Investigative Pathology and American Society for Clinical Pathology. (Source: UCLA Newsroom: Health Sciences)
Source: UCLA Newsroom: Health Sciences - November 24, 2014 Category: Universities & Medical Training Source Type: news

Is UK obesity fuelling an increase in 10 cancers?
Conclusion This large UK cohort study of more than 5 million people has found that, although there was variation in the effect of BMI on different cancers, a higher BMI was associated with increased risk of several cancers. Overall, the researchers estimated that a 1kg/m² population-wide increase in BMI would result in 3,790 additional people in the UK each year developing uterus, gallbladder, kidney, cervix, thyroid, leukaemia, liver, colon, ovarian or postmenopausal breast cancer. However, not all of the identified links were completely clear, with some showing a clearer linear association between increasing BMI an...
Source: NHS News Feed - August 14, 2014 Category: Consumer Health News Tags: Obesity Cancer Source Type: news

Stanford researchers develop smartphone peripheral to scan for oral cancer
Stanford University’s Prakash Lab has developed a smartphone peripheral to diagnose oral cancer, called Oscan. The peripheral device has a mouthpiece and a camera mount. Users follow the upper and lower bite guides to help them take the desired shots of the inside of their mouth. According to the researchers, screenings of the oral cavity [...] (Source: mobihealthnews)
Source: mobihealthnews - May 1, 2014 Category: Information Technology Authors: Aditi Pai Tags: Uncategorized dental hygiene oral cancer oral care Oscan Prakash Lab Stanford University Source Type: news

Smoking 'increases risk of breast cancer in older women by almost a fifth'
Study published in British Journal of Cancer found women who used to smoke were still 7% more at risk of diseaseSmoking increases the risk of breast cancer in older women by almost a fifth, a study has found. The discovery adds to a growing weight of evidence linking exposure to tobacco smoke with the disease.US scientists who tracked the progress of around 186,000 women aged 50 to 71 found that those who smoked were 19% more likely to develop breast cancer than those who had never smoked. Women who once smoked but then kicked the habit were still 7% more at risk.The results held true even after accounting for alcohol cons...
Source: Guardian Unlimited Science - March 19, 2014 Category: Science Tags: The Guardian United States World news Health Smoking Medical research Society Cancer UK news Breast cancer Science Source Type: news

Surgery 'better than chemotherapy' for tongue cancer
For the treatment of cancer, many would consider chemotherapy to be the best option. But for tongue cancer, new research suggests that surgery may be the most effective primary port of call. This is according to a study published in the journal JAMA Otolaryngology Head and Neck Surgery.According to the American Cancer Society, approximately 36,000 people will have been diagnosed with oral cavity or oropharyngeal cancers, which includes tongue cancer, in the US throughout 2013. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 30, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer
Our laboratory has f cancer prevention using freeze-dried berries, mainly black raspberries, for more than two decades. Berries contain many known agents with chemopreventive potential including certain vitamins, minerals, simple and complex polyphenols, phytosterols, and various fiber constituents. Because berries are approximately 80–90 % water, the freeze-drying process concentrates these bioactive constituents approximately tenfold. This chapter describes methods we use to harvest the berries, grind them into a powder, and determine the nutrient, chemical, and microbial content of the powder before use in both pr...
Source: Springer protocols feed by Pharmacology/Toxicology - November 27, 2013 Category: Drugs & Pharmacology Source Type: news

UCLA Dentistry discovers cellular signals between pancreatic cancer tumors and saliva
This study was funded in part by Public Health Service grants R01DE17170, UH2/UH3 TR000923 and T32DE07296, and SOD Faculty Seed Grants from the UCLA School of Dentistry (441901-69749-FWEIFY11DR).   The UCLA School of Dentistry is dedicated to improving the oral and systemic health of the people of California, the nation and the world through its teaching, research, patient care and public service initiatives. The School of Dentistry provides education and training programs that develop leaders in dental education, research, the profession and the community. The School of Dentistry also conducts research programs that ...
Source: UCLA Newsroom: Health Sciences - October 8, 2013 Category: Universities & Medical Training Source Type: news

Sentinel Node Biopsy Adequate for Staging Oral Cancer
Neck dissection may no longer be the only surgical option for pathologic staging of the neck in patients with oral cavity squamous cell carcinoma, according to a new study. (Source: Cancer Network)
Source: Cancer Network - July 29, 2013 Category: Cancer & Oncology Source Type: news

Tea and coffee may protect against oral cancer
Consumption of tea and coffee is inversely correlated with the risk for cancer of the oral cavity, a large population-based study suggests. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - April 22, 2013 Category: Cancer & Oncology Source Type: news

A Promising Drug Can Help Prevent Head And Neck Cancers
Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions. The most common type of change is a white patch known as a leukoplakia. Because it often takes decades for leukoplakias to develop into HNSCC, there is a window of opportunity to recognize and revert precancerous changes, thus preventing this type of cancer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 11, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Lymph node ratio predicts RT benefit for oral cancer
Radiation therapy (RT) can benefit some patients with oral cavity squamous (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 3, 2013 Category: Radiology Source Type: news