New Data Show TREMFYA ® (guselkumab) Binds to Both Inflammatory Cells and Interleukin (IL)-23, Supporting a Hypothesis for a Differentiated Mechanism from Risankizumab
SPRING HOUSE, PENNSYLVANIA, May 18, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the first results of the in vitro MODIF-Y studies, supporting a hypothesis that may differentiate the mechanism of first-in-class TREMFYA® (guselkumab) from risankizumab due to the ability of TREMFYA to bind to CD64 positive (CD64+) cells in addition to interleukin (IL)-23 — both of which are key components of the immune system. 1,2 These findings, which are being presented at the Society for Investigative Dermatology (SID) annual meeting May 18-21, 2022 in Portland, Oregon, demonstrate TREMFYA bind...
Source: Johnson and Johnson - May 18, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Obesity Linked to Increased Risk for Crohn Disease
TUESDAY, May 17, 2022 -- Obesity, as measured by body mass index (BMI), is associated with an increased risk for Crohn disease (CD) but not ulcerative colitis (UC), according to a study published in the May issue of Clinical Gastroenterology&... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 17, 2022 Category: Pharmaceuticals Source Type: news

Heavy Antibiotic Use Tied to Development of Crohn's, Colitis
Title: Heavy Antibiotic Use Tied to Development of Crohn ' s, ColitisCategory: Health NewsCreated: 5/13/2022 12:00:00 AMLast Editorial Review: 5/13/2022 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - May 13, 2022 Category: Nutrition Source Type: news

348 Unusual Child Hepatitis Cases; Rinvoq Impresses in Crohn's; ED and Cirrhosis
(MedPage Today) -- As of Tuesday, there are 348 probable cases of child hepatitis of unknown origin in 21 countries, with 26 cases requiring liver transplants, the World Health Organization announced. Is there a link between the Omicron variant... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - May 12, 2022 Category: Gastroenterology Source Type: news

Crohn ’s Disease: Developing Drugs for Treatment
Crohn ’s Disease: Developing Drugs for Treatment (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 28, 2022 Category: Drugs & Pharmacology Authors: FDA Source Type: news

TNF Blockers Beat Newer Biologics in Crohn's Disease TNF Blockers Beat Newer Biologics in Crohn's Disease
TNF blockers may work better than newer biologics for treating moderate to severe Crohn ' s disease.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - April 28, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Perianal Fistulas in Crohn's Signal Greater Disease Burden
(MedPage Today) -- Crohn's disease patients with perianal fistulas (PF) or a history of them had greater disease burden and more often required hospitalization, surgery, and medication for their disease, data from a U.S. registry showed. In the... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 27, 2022 Category: Gastroenterology Source Type: news

Pregnant Woman With Crohn's Disease Experiences Perianal Pain
(MedPage Today) -- Pain may be sole symptom of Fournier's gangrene in the immunosuppressed (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 25, 2022 Category: Gastroenterology Source Type: news

Adding Thiopurines to Vedolizumab Has Benefits in Crohn's Disease Adding Thiopurines to Vedolizumab Has Benefits in Crohn's Disease
For patients with Crohn ' s disease, combining thiopurines with vedolizumab may be more effective than vedolizumab alone, new findings suggest.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - April 18, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Crohn's Fistulas Heal Better With Combined Surgical-TNF Blocker Approach
(MedPage Today) -- Surgical closure of perianal fistulas in Crohn's disease (CD), when combined with short-term tumor necrosis factor (TNF) inhibitors, improved radiologic healing and other outcomes compared to medication alone, the PISA II trial... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 18, 2022 Category: Gastroenterology Source Type: news

The Connection Between IBD and Aging
Inflammatory bowel disease (IBD) has long been thought of as an ailment of middle, or even young, adulthood. The chronic illness—which includes Crohn’s disease and ulcerative colitis, and can cause abdominal pain, diarrhea, bleeding, and decreased quality of life—impacts about 3.1 million people in the U.S. However, it is far from a disease only of the young and middle-aged. More than a quarter of people with IBD are elderly, a figure that is projected to climb to 30% by 2030, according to a 2021 Gastroenterology & Hepatology article. Even more underappreciated is the growing population of people who ...
Source: TIME: Health - April 8, 2022 Category: Consumer Health News Authors: Katherine Harmon Courage Tags: Uncategorized Disease healthscienceclimate Source Type: news

New NHS blood test provides hope for Crohn's disease sufferers
The UK-developed test, called PredictSURE IBD, is designed to assess the severity of Crohn's and ulcerative colitis, conditions that cause inflammation and ulceration inside the gut. (Source: the Mail online | Health)
Source: the Mail online | Health - April 2, 2022 Category: Consumer Health News Source Type: news

Toss Up for Second-Line IBD Tx; Screening for Esophageal Cancer; 100 Colon Polyps
(MedPage Today) -- Effectiveness of vedolizumab (Entyvio) and tofacitinib (Xeljanz) for ulcerative colitis or vedolizumab and ustekinumab (Stelara) for Crohn's disease did not significantly differ among patients who failed on tumor necrosis factor... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 31, 2022 Category: Gastroenterology Source Type: news

Does Crohn's Affect Your Eyes?
Title: Does Crohn ' s Affect Your Eyes?Category: Diseases and ConditionsCreated: 3/29/2022 12:00:00 AMLast Editorial Review: 3/29/2022 12:00:00 AM (Source: MedicineNet Eyesight General)
Source: MedicineNet Eyesight General - March 29, 2022 Category: Opthalmology Source Type: news

Restroom Access Act sails through RI House
The Rhode Island House on Thursday passed a bill that would let people with certain medical issues or who are pregnant use employee restrooms at retail establishments that don ’t have public facilities. Such bills are championed by the Crohn's and Colitis Foundation. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 25, 2022 Category: Biotechnology Authors: Mary Serreze Source Type: news