What Are Systemic Disease Causes of Oral Ulcers?
Discussion Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range. Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Source: PediatricEducation.org - September 21, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

He Had Recurring Pain for Nearly a Decade
The muscles from his buttock down to his calf felt as if they were on fire. He saw countless specialists, but nothing really seemed to help. What could it possibly be? (Source: NYT Health)
Source: NYT Health - September 15, 2020 Category: Consumer Health News Authors: Lisa Sanders, M.D. Tags: Crohn ' s Disease Digestive Tract Immune System Arthritis Colitis Source Type: news

University of South Carolina study reveals how cannabinoids may be useful to prevent colon cancer
(University of South Carolina) Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are caused by inflammation of the gastrointestinal tract. Patients with IBD are at a higher risk of developing colorectal cancer. A UofSC study shows that THC suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 15, 2020 Category: Cancer & Oncology Source Type: news

What Is Ulcerative Colitis, the Ailment Afflicting Shinzo Abe of Japan?
The disease that has afflicted Prime Minister Shinzo Abe of Japan is a chronic malady that can strike at a young age and flare up unpredictably. (Source: NYT Health)
Source: NYT Health - August 28, 2020 Category: Consumer Health News Authors: Rick Gladstone Tags: Digestive Tract Colitis Bowels Crohn ' s Disease Colon Clinical Gastroenterology and Hepatology (Journal) Massachusetts General Hospital Abe, Shinzo Source Type: news

Childbearing and Short-Term Risk of Crohn Disease in Mothers Childbearing and Short-Term Risk of Crohn Disease in Mothers
Does childbearing influence the risk of inflammatory bowel disease?American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 18, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

How Serious Is Crohn ’s Disease?
Title: How Serious Is Crohn ’s Disease?Category: Diseases and ConditionsCreated: 8/10/2020 12:00:00 AMLast Editorial Review: 8/10/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - August 10, 2020 Category: Nutrition Source Type: news

Roche provides update on phase III studies of etrolizumab in people with moderately to severely active ulcerative colitis
Basel, 10 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced topline results from its phase III study programme evaluating the investigational medicine etrolizumab in people with moderately to severely active ulcerative colitis. Mixed results were seen in studies evaluating etrolizumab as an induction therapy, and both studies evaluating etrolizumab as a maintenance therapy failed to meet their primary endpoints, showing no significant difference in the proportion of people achieving remission with subcutaneous etrolizumab versus placebo. In the HIBISCUS I induction study, in people without prior anti-tumour ...
Source: Roche Media News - August 10, 2020 Category: Pharmaceuticals Source Type: news

Roche provides update on phase III studies of etrolizumab in people with moderately to severely active ulcerative colitis
Basel, 10 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced topline results from its phase III study programme evaluating the investigational medicine etrolizumab in people with moderately to severely active ulcerative colitis. Mixed results were seen in studies evaluating etrolizumab as an induction therapy, and both studies evaluating etrolizumab as a maintenance therapy failed to meet their primary endpoints, showing no significant difference in the proportion of people achieving remission with subcutaneous etrolizumab versus placebo. In the HIBISCUS I induction study, in people without prior anti-tumour ...
Source: Roche Investor Update - August 10, 2020 Category: Pharmaceuticals Source Type: news

What Are the Five Types of Crohn's Disease?
Title: What Are the Five Types of Crohn's Disease?Category: Diseases and ConditionsCreated: 8/7/2020 12:00:00 AMLast Editorial Review: 8/7/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - August 7, 2020 Category: Nutrition Source Type: news

What Is the Life Expectancy of Someone with Crohn's Disease?
Title: What Is the Life Expectancy of Someone with Crohn's Disease?Category: Diseases and ConditionsCreated: 8/4/2020 12:00:00 AMLast Editorial Review: 8/4/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - August 4, 2020 Category: Nutrition Source Type: news

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease
Anti–tumor necrosis factor (anti-TNF) therapy resistance is a major clinical challenge in inflammatory bowel disease (IBD), due, in part, to insufficient understanding of disease-site, protein-level mechanisms. Although proteomics data from IBD mouse models exist, data and phenotype discrepancies contribute to confounding translation from preclinical animal models of disease to clinical cohorts. We developed an approach called translatable components regression (TransComp-R) to overcome interspecies and trans-omic discrepancies between mouse models and human subjects. TransComp-R combines mouse proteomic data with pa...
Source: Signal Transduction Knowledge Environment - August 4, 2020 Category: Science Authors: Brubaker, D. K., Kumar, M. P., Chiswick, E. L., Gregg, C., Starchenko, A., Vega, P. N., Southard-Smith, A. N., Simmons, A. J., Scoville, E. A., Coburn, L. A., Wilson, K. T., Lau, K. S., Lauffenburger, D. A. Tags: STKE Research Articles Source Type: news

Ortikos (budesonide), the First and Only Once-Daily Dose for Treatment of Mild to Moderate Crohn ’s Disease, Now Available in the U.S.
Parsippany, NJ– July 29, 2020– Ferring Pharmaceuticals Inc. today announced the launch of Ortikos (budesonide) in the United States, which is approved as the only once-daily treatment of mild to moderate active Crohn’s disease... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 30, 2020 Category: Drugs & Pharmacology Source Type: news

Help Shape Our Reporting on Disability and Accessibility in America
Our journalists want to hear your questions about and experiences with disability and accessibility in the U.S. (Source: NYT Health)
Source: NYT Health - July 10, 2020 Category: Consumer Health News Authors: Hannah Wise Tags: Crohn ' s Disease Americans With Disabilities Act United States Source Type: news

Inflammatory Bowel Disease Tied to Increased Dementia Risk
Those with Crohn ’s disease or ulcerative colitis had higher rates of Alzheimer’s disease and other forms of dementia. (Source: NYT Health)
Source: NYT Health - July 2, 2020 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Alzheimer ' s Disease Dementia Digestive Tract Crohn Source Type: news

Could Crohn's, Colitis Raise Dementia Risk?
Title: Could Crohn's, Colitis Raise Dementia Risk?Category: Health NewsCreated: 6/23/2020 12:00:00 AMLast Editorial Review: 6/24/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - June 24, 2020 Category: Nutrition Source Type: news

Ultrasound Score Promising Measure of Crohn's Disease Ultrasound Score Promising Measure of Crohn's Disease
An ultrasound activity index combining bowel-wall thickness and color Doppler appears to be a useful surrogate marker of endoscopic activity in patients with Crohn's disease, according to Norwegian researchers.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 23, 2020 Category: Pathology Tags: Gastroenterology News Source Type: news

Could Crohn's, Colitis Raise Dementia Risk?
TUESDAY, June 23, 2020 -- People with inflammatory bowel disease might be vulnerable to developing dementia, a new study suggests. Inflammatory bowel disease, or IBD, is an umbrella term for ulcerative colitis and Crohn's disease. Both cause chronic... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 23, 2020 Category: General Medicine Source Type: news

Cloning stem cells to find a cure for Crohn's disease
(University of Houston) Researchers at the University of Houston Stem Cell Center are developing new drug therapies to selectively destroy rogue cells they found in biopsies of pediatric Crohn's patients, to create new treatments for the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 18, 2020 Category: International Medicine & Public Health Source Type: news

Treatment With Two Biologics in Refractory Crohn's Disease Treatment With Two Biologics in Refractory Crohn's Disease
Might simultaneous treatment with two biologics provide improved outcomes in patients who previously have failed multiple biologic therapies?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Perianal Fistulizing Complications Preventable in Crohn Disease
TUESDAY, June 16, 2020 -- For young patients with Crohn disease (CD), use of steroid-sparing therapy (SST) is associated with a reduced risk for perianal fistulizing complications (PFCs), according to a study published online June 9 in JAMA Network... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 16, 2020 Category: Pharmaceuticals Source Type: news

Steroid-sparing therapies reduce fistula risk by 60% in young people with Crohn's, study finds
Steroid-sparing treatments can prevent young people with Crohn's disease from developing perianal fistulas, a serious complication associated with the condition, according to a study published by JAMA Network Open. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 9, 2020 Category: Consumer Health News Source Type: news

What Are the First Signs of Crohn ’s Disease?
Title: What Are the First Signs of Crohn ’s Disease?Category: Diseases and ConditionsCreated: 6/4/2020 12:00:00 AMLast Editorial Review: 6/4/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - June 4, 2020 Category: Nutrition Source Type: news

Understanding a gene's role in inflammatory bowel disease
(University of California - Riverside) A protein-coding gene associated with autoimmune diseases such as Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease, or IBD, will be the focus of new research in the School of Medicine at the University of California, Riverside. The work is made possible by a National Institutes of Health grant exceeding $2.5 million. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 4, 2020 Category: International Medicine & Public Health Source Type: news

Exclusive Enteral Nutrition Formulas Used in Crohn's Disease Exclusive Enteral Nutrition Formulas Used in Crohn's Disease
This study analyzed nonnutrient food ingredients and food additive composition of EEN formulas.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Early Biologic Treatment in Patients With Crohn's Disease Early Biologic Treatment in Patients With Crohn's Disease
Does earlier initiation of biologic therapy improve outcomes in adults and children with Crohn's disease?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 18, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Artificial sweetener could worsen symptoms of Crohn's disease
(Natural News) “Sugar-free” artificial sweeteners might not be a healthier alternative to sugar after all. On the contrary, it can trigger inflammation and worsen symptoms of Crohn’s disease, a recent animal study showed. Published in Inflammatory Bowel Diseases, it revealed that Splenda, a type of zero-calorie artificial sweetener, exacerbated gut inflammation in mice with Crohn’s disease.... (Source: NaturalNews.com)
Source: NaturalNews.com - May 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus and Crohn’s disease: Dangers of COVID-19 to the inflammatory bowel disease
CORONAVIRUS can be extremely dangerous to those on immunosuppressants. And, for people with Crohn's disease, taking immunosuppressants is a way of life. What do you need to know about the high-risk condition? (Source: Daily Express - Health)
Source: Daily Express - Health - April 30, 2020 Category: Consumer Health News Source Type: news

Cochrane Review confirms effectiveness of MMR vaccines
New evidence published in the Cochrane Library today finds MMR, MMRV and MMR+V vaccines are effective and that they are not associated with increased risk of autism. Measles, mumps, rubella and varicella (also known as chickenpox) are infectious diseases caused by viruses. They are most common in children and young adults, and can lead to potentially fatal illnesses, disabilities and death. Measles remains one of the leading causes of childhood death around the globe. Rubella is also dangerous for pregnant women, as it can cause miscarriage or harm to unborn babies. The MMR (measles, mumps, rubella) is a combined...
Source: Cochrane News and Events - April 17, 2020 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Australia's Centre for Digestive Diseases cures Crohn's disease in new study
(Digital Mantra Group) The Centre for Digestive Disease (CDD) headed by Professor Thomas Borody has cured Crohn's Disease as reported today by Dr Gaurav Agrawal in Gut Pathogens. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2020 Category: International Medicine & Public Health Source Type: news

The effects of inflammatory bowel disease on pregnancy
(Wiley) Inflammatory bowel disease (IBD) -- including Crohn's disease and ulcerative colitis -- often affects women of childbearing age. A study published in Alimentary Pharmacology& Therapeutics compared the health of pregnant and non-pregnant women with IBD. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 8, 2020 Category: International Medicine & Public Health Source Type: news

Early Deep Remission of Crohn Disease Tied to Better Outcomes
FRIDAY, April 3, 2020 -- Deep early remission of Crohn disease is associated with a significant decrease in long-term adverse effects, according to a study published online March 26 in Gastroenterology. Ryan C. Ungaro, M.D., from the Icahn School... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 3, 2020 Category: Pharmaceuticals Source Type: news

Ustekinumab reduces costs and utilisation in US patients with Crohn's disease
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - April 1, 2020 Category: Drugs & Pharmacology Source Type: news

Patients and RWE: Is this the year?
The long-hyped redefinition of healthcare through wearable tech has been … well, long hyped. Early projects, such as Apple HealthKit and Fitbit, were undoubtably important in redefining ‘the possible’ but they haven’t yet achieved transformative application.  Much has been written on why the philosophy that has driven the astonishing success of consumer technology doesn ’t translate to healthcare and when we look at the state of innovation in 2020, many of these structural issues remain.   As Emily Cerciello, Associate Director, Digital Health and Engagement at the Crohn's...
Source: EyeForPharma - March 26, 2020 Category: Pharmaceuticals Authors: Tom Disley Source Type: news

Patients and RWE: Is this the year?
The long-hyped redefinition of healthcare through wearable tech has been … well, long hyped. Early projects, such as Apple HealthKit and Fitbit, were undoubtably important in redefining ‘the possible’ but they haven’t yet achieved transformative application.  Much has been written on why the philosophy that has driven the astonishing success of consumer technology doesn ’t translate to healthcare and when we look at the state of innovation in 2020, many of these structural issues remain.   As Emily Cerciello, Associate Director, Digital Health and Engagement at the Crohn's...
Source: EyeForPharma - March 26, 2020 Category: Pharmaceuticals Authors: Tom Disley Source Type: news

Patients and RWE: Is this the year?
The long-hyped redefinition of healthcare through wearable tech has been … well, long hyped. Early projects, such as Apple HealthKit and Fitbit, were undoubtably important in redefining ‘the possible’ but they haven’t yet achieved transformative application.  Much has been written on why the philosophy that has driven the astonishing success of consumer technology doesn ’t translate to healthcare and when we look at the state of innovation in 2020, many of these structural issues remain.   As Emily Cerciello, Associate Director, Digital Health and Engagement at the Crohn's...
Source: EyeForPharma - March 26, 2020 Category: Pharmaceuticals Authors: Tom Disley Source Type: news

Mount Sinai researchers unveil mechanisms to prevent Crohn's disease
(The Mount Sinai Hospital / Mount Sinai School of Medicine) In a series of four studies published today in Gastroenterology, a journal of the American Gastroenterological Association, Mount Sinai inflammatory bowel disease (IBD) researchers, describe the identification of predictive tools and a new understanding of environmental factors that trigger IBD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2020 Category: International Medicine & Public Health Source Type: news

FDA approves ozanimod, a drug invented at Scripps Research, for multiple sclerosis
(Scripps Research Institute) The US Food and Drug Administration has approved ozanimod, an immune-modulating therapy invented at Scripps Research, for the treatment of adults with relapsing forms of multiple sclerosis. The drug is also in advanced clinical development for adults and children with moderate-to-severe ulcerative colitis and Crohn's disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2020 Category: International Medicine & Public Health Source Type: news

A Tool for Optimizing Vedolizumab Therapy in Crohn's Disease A Tool for Optimizing Vedolizumab Therapy in Crohn's Disease
This study extended the clinical utility of a previously validated clinical decision support tool for predicting treatment effectiveness of vedolizumab in Crohn's disease.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 25, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

A protein that controls inflammation
(VIB (the Flanders Institute for Biotechnology)) A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis. They discovered how the protein A20 prevents inflammation and autoimmunity, not through its enzymatic activities as has been proposed, but through a non-enzymatic mechanism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2020 Category: International Medicine & Public Health Source Type: news

Potential of glucocorticoids to treat intestinal inflammation during sepsis
Glucocorticoids (GCs) are steroid hormones characterized by their anti-inflammatory and immunosuppressive nature. Although GCs are very commonly prescribed, in several diseases, including sepsis, their clinical treatment is hampered by side effects and by the occurrence of glucocorticoid resistance (GCR). Sepsis is defined as a life-threatening organ dysfunction, initiated by a dysregulated systemic host response to infections. With at least 19 million cases per year and a lethality rate of about 25%, sepsis is one of the most urgent unmet medical needs. The gut is critically affected during sepsis and is considered as a d...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

Ultrasound predicts which kids benefit from colitis meds
Bowel ultrasound scans may be able to predict which children need second-line...Read more on AuntMinnie.comRelated Reading: Cinematic rendering complements CT in diagnosing colitis Immuno-PET could aid patients with inflammatory diseases 3 ways cinematic rendering can bolster colon evaluation CEUS can aid assessment of Crohn's disease activity PET/CT enhances detection of inflammatory bowel disease (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 6, 2020 Category: Radiology Source Type: news

Consumer Health: Inflammatory bowel disease and colon cancer screening
If you have inflammatory bowel disease, you may be worried about colon cancer. Inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, is an umbrella term used to describe disorders that involve chronic inflammation of your digestive tract. It's important to understand that while inflammatory bowel disease increases your risk of colon cancer, it doesn't necessarily [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 6, 2020 Category: Databases & Libraries Source Type: news

Crohn's Disease, Ulcerative Colitis, and Lipid Profiles Crohn's Disease, Ulcerative Colitis, and Lipid Profiles
The population-based study evaluated the association of developing IBD with serum lipid profiles. Did Crohn's disease and ulcerative colitis patients differ in their profile characteristics?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 4, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Crohn's disease nearly destroyed Tom Speight's career just as it was taking off 
Singer-songwriter Tom Speight, 33, is one of 115,000 Britons who have Crohn's disease, a condition in which the lining of the digestive system becomes inflamed and often ulcerated. (Source: the Mail online | Health)
Source: the Mail online | Health - March 3, 2020 Category: Consumer Health News Source Type: news

Dynamo: How Crohn's made me '150% better at magic'
The magician recalls how his poor health nearly robbed him of the use of his hands to perform. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 5, 2020 Category: Consumer Health News Source Type: news

Vedolizumab and Malignancy Incidence Vedolizumab and Malignancy Incidence
This study analyzed the long-term incidence of malignancy with vedolizumab, a gut-selective antibody approved to treat moderate-to-severe Crohn's disease and ulcerative colitis in adults.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 22, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

IBD Diagnoses Rising in Children IBD Diagnoses Rising in Children
Advances in anti-TNF drugs will be in the spotlight at the upcoming Crohn's and Colitis Congress. One expert believes a cure will come in the lifetime of some of the children he currently treats.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 21, 2020 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Fungal Alterations in Inflammatory Bowel Diseases Fungal Alterations in Inflammatory Bowel Diseases
This review explores the role of gut fungi in patients with Crohn's disease and ulcerative colitis. Might modulation of the fungal microbiota present a therapeutic opportunity for IBD?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 15, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Crohn's Disease
Title: Crohn's DiseaseCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 1/14/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - January 14, 2020 Category: Nutrition Source Type: news

Stopping Anti-TNF Therapy in Perianal Crohn's Disease Stopping Anti-TNF Therapy in Perianal Crohn's Disease
Does stopping anti-TNF therapy in patients with perianal Crohn's disease result in relapse?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 8, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news