Answer to Case 684
Answer to theParasite Case of the Week 684: Anisakid L3 larvaeThe following is our third and final discussion from our amazing guest author and 3rd year medical student, Hadel Go. I ' m sure you will all agree that her discussions have been among the best we ' ve ever had on this blog. Congratulations on the excellent work, Hadel!_____________________ Worm cases are always my favorite because the comments are either “They are so beautiful!!” (@Parasite_Power on Twitter) or “…That’s a wholelottanope” (Valmik in the comments).This is a nematode in the Anisakidae family, likelyPseudoterranovaorAnisakis spp., ...
Source: Creepy Dreadful Wonderful Parasites - May 30, 2022 Category: Parasitology Source Type: blogs

Underfunding Research Of Female Health Leaves Huge Amounts Of Money On The Table
“Did you know that at least one-third of women have lower back pain before their periods every month, and yet, nobody seems to fully understand why?” – asked a Medical Futurist team member a little while ago. The question led to a discussion about the differences in research, funding and understanding of male-only and female-only health issues, and consequently, to this article. It is a well-known fact that some diseases or conditions dominantly affect one gender or the other. There are the trivial ones, like prostate cancer or ovarian, cervical, uterine cancers. But there is a long list of diseases and condit...
Source: The Medical Futurist - May 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Healthcare Policy Medical Education women female health under-reseached gender gap in healthcare Source Type: blogs

Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aging of the Intestinal Barrier as a Driving Cause of Chronic Inflammation
Chronic inflammation is a feature of aging, and causes disruption of cell and tissue function throughout the body. Short term inflammation is a necessary feature of regeneration from injury and defense against pathogens, but when inflammatory signaling is maintained for the long term it becomes very harmful. The risk of suffering all of the common diseases of aging is strongly connected to raised inflammation. Given this, we might ask what causes age-related systemic inflammation, and thus where should the research community seek to intervene, in order to reverse this undesirable aspect of degenerative aging. A grow...
Source: Fight Aging! - March 29, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

How did we let insurers run health care?
How did we Americans allow health insurers to dictate how physicians practice good medicine? The hypocritic oath says,“Do no harm.” We should not allow insurance company profits to prevent proper care for patients. Our insurer is now telling our young adult son, a Crohn’s patient (Crohn’s is not yet a curable disease), who hasRead more …How did we let insurers run health care? originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 15, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/gary-lawson-and-marcia-lawson" rel="tag" > Gary Lawson and Marcia Lawson < /a > < /span > Tags: Meds Gastroenterology Medications Public Health & Policy Source Type: blogs

Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming. In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs

Future Treatment For Autoimmune Diseases
New digital health tech targeted to fight autoimmune diseases or their symptoms are diverse and creative. These often completely different illnesses, like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis, indicate an immune system dysfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation. An estimated 24-50 million people in the US alone are living with autoimmune conditions. It affects their day-to-day life, but scientists suggest people living with chronic conditions could also be more suscepti...
Source: The Medical Futurist - July 29, 2021 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine Portable Medical Diagnostics Telemedicine & Smartphones chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs

Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

In Horses, the Gut Microbiome Interacts with Mitochondria to Improve Function
The study here is carried out in horses, but it is reasonable to expect to find very similar mechanisms in other mammals. The beneficial populations of the gut microbiome provide metabolites that steer cell function and exist in symbiosis with the host animal. Mitochondria, the power plants of the cell, are the evolved descendants of ancient symbiotic microbes, now an integral part of cellular processes. It is reasonable to think that the one can influence the other directly via signaling processes, as researchers discuss in these materials and elsewhere. In humans, for example, researchers have found that propionate gener...
Source: Fight Aging! - April 14, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Michelin Star Medicine: Food Start-Up Epicured Delivers Meals for GI & Chronic Condition Care
By JESSICA DaMASSA, WTF HEALTH Food-as-Medicine startup, Epicured, looks and acts a lot like the consumer meal delivery startups booming during this pandemic (think Freshly, which was just acquired by Nestle for $1.5B) but with one important difference: all the meals are based on diets that have been clinically validated as treatments for chronic disease. The three year old company got its start in GI disorders, turning complex Low FODMAP diets, gluten-free diets, etc. into home-delivered, ready-to-eat dishes that patients with Crohn’s disease, Colitis, IBS, IBD, celiac, or other gastro conditions could actually i...
Source: The Health Care Blog - December 8, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Jessica DaMassa WTF Health Epicured Source Type: blogs

Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest. BMP6 as a Target for Pro-Angiogenic Therapies https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/ Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Interventions Targeting the Aging of the Gut Microbiome
Age-related changes to the microbial populations of the gut, the gut microbiome, appear important in the progression of aging. The effects on long-term health and risk of age-related conditions might be on a par with those of physical activity, and certainly overlap with those of diet. With ageing, beneficial microbes that produce metabolites (such as butyrate) that lead to better tissue function diminish in number, while harmful microbes that spur chronic inflammation grow in number. This may be due to loss of immune system competency, as the immune system gardens the gut microbiome, or it may be due to diminished intesti...
Source: Fight Aging! - October 19, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Early, tight control of Crohn ’s disease may have lasting benefits
The gastrointestinal (GI) tract is a remarkable organ: it resides on the inside of our bodies, but is regularly in contact with the outside world by virtue of what we ingest. It is quite incredible that the immune cells of the GI tract are not activated more regularly by the many foreign products it encounters every day. Only when the GI tract encounters an intruder that risks causing disease do the immune cells of the GI tract spring into action. That is, of course, under normal circumstances. In people with Crohn’s disease, the normally tolerant immune cells of the GI tract are activated without provocation, and this a...
Source: Harvard Health Blog - October 16, 2020 Category: Consumer Health News Authors: Sarah Flier, MD Tags: Digestive Disorders Source Type: blogs

Case of the Week 604
 This week ' s case was generously donated by Dr. Peter Gilligan, and features a histopathology section of an appendix from a patient with Crohn ' s disease. The pathologist was concerned when they saw the following object in the lumen of the appendix. Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - August 31, 2020 Category: Parasitology Source Type: blogs

Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs