Inflammatory bowel disease: recent developments
Paediatric-onset inflammatory bowel disease (IBD) is a complex and heterogenous condition. Incidence of disease in those aged <18 years has doubled over the last 25 years, with concurrent increased prevalence and no decrease in disease severity. The tools available at diagnosis for investigation have developed over the last 10 years, including better utilisation of faecal calprotectin, improved small bowel imaging and video capsule endoscopy. Alongside this, management options have increased and include biological and small molecule therapies targeting alternative pathways (such as interleukin 12/23, integrins and Janus...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Ashton, J. J., Beattie, R. M. Tags: Open access Review Source Type: research
Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data
CONCLUSIONS: Five literature models effectively described adalimumab PK in this pediatric cohort, highlighting the potential for extrapolating existing models to the pediatric population. The new JIA model confirmed the effect of several known covariates and found a novel association for drug clearance with methotrexate use (lower) and uveitis (higher), which might have clinical relevance for personalized dosing in JIA.PMID:38630199 | DOI:10.1007/s40272-024-00629-7 (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 17, 2024 Category: Pediatrics Authors: Amara Nassar-Sheikh Rashid Femke Hooijberg Sandy C Bergkamp Mariken P Gruppen Taco W Kuijpers Mike Nurmohamed Theo Rispens Gertjan Wolbink J Merlijn van den Berg Dieneke Schonenberg-Meinema Ron A A Math ôt Source Type: research
Factors associated with surgical resection in patients with Crohn's disease: long-term evaluation
CONCLUSIONS: Patients with CD still frequently need surgical treatment. Smoking (current or past), longer disease time, stenosing and fistulizing behavior, and ileo-colonic localization in CD patients were associated with a higher risk of surgery. Awareness about factors associated with unfavorable outcome allows such patients to be treated more appropriately.PMID:38629651 | PMC:PMC11020661 | DOI:10.1590/acb391924 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - April 17, 2024 Category: Surgery Authors: Sandro da Costa Ferreira L ílian Rose Otoboni Aprile Rog ério Serafim Parra Marley Ribeiro Feitosa Patr ícia Picardi Morais de Castro Gleici de Castro da Silva Perdon á Omar Feres Jos é Joaquim Ribeiro da Rocha Luiz Ernesto de Almeida Troncon Source Type: research
Cystitis glandularis with concomitant Crohn ’s disease leading to a paroxysm of Crohn’s disease with ulcerated external iliac vessels
•we report the case of a 36-year-old female patient who presented to our hospital with a diagnosis of cystitis glandularis manifesting as a vesicovaginal fistula. She underwent cystoscopic biopsy at a local ho... (Source: BMC Urology)
Source: BMC Urology - April 17, 2024 Category: Urology & Nephrology Authors: Wu Ronghua, Zheng Ji, Liu Gang, Zhang Yun and Nie Xubiao Tags: Case Report Source Type: research
Defining predictors of responsiveness to advanced therapies in Crohns disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine
Introduction
Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients.
Current understanding of IBD pathogenesis implicates complex interactions between host genetics and the gut microbiome. Most cohorts s...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Wyatt, N. J., Watson, H., Anderson, C. A., Kennedy, N. A., Raine, T., Ahmad, T., Allerton, D., Bardgett, M., Clark, E., Clewes, D., Cotobal Martin, C., Doona, M., Doyle, J. A., Frith, K., Hancock, H. C., Hart, A. L., Hildreth, V., Irving, P. M., Iqbal, S. Tags: Open access, Gastroenterology and hepatology Source Type: research
Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - April 17, 2024 Category: Allergy & Immunology Authors: Francesca Lusetti Ferdinando D'Amico Mariangela Allocca Federica Furfaro Alessandra Zilli Gionata Fiorino Tommaso Lorenzo Parigi Simona Radice Laurent Peyrin-Biroulet Silvio Danese Source Type: research
Pediatric stricturing Crohn's disease
World J Gastroenterol. 2024 Mar 28;30(12):1651-1654. doi: 10.3748/wjg.v30.i12.1651.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strict...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Alessandro Boscarelli Matteo Bramuzzo Source Type: research
Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
CONCLUSION: Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD, especially the former.PMID:38617736 | PMC:PMC11008375 | DOI:10.3748/wjg.v30.i12.1751 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study
CONCLUSION: WMT demonstrated therapeutic efficacy in CD treatment, likely due to the effective reconstruction of the patient's microbiome. Multi-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.PMID:38617453 | PMC:PMC11008410 | DOI:10.3748/wjg.v30.i11.1572 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Source Type: research
Pediatric stricturing Crohn's disease
World J Gastroenterol. 2024 Mar 28;30(12):1651-1654. doi: 10.3748/wjg.v30.i12.1651.ABSTRACTCrohn's disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strict...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Alessandro Boscarelli Matteo Bramuzzo Source Type: research
Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
CONCLUSION: Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD, especially the former.PMID:38617736 | PMC:PMC11008375 | DOI:10.3748/wjg.v30.i12.1751 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang Source Type: research
Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research
Washed microbiota transplantation for Crohn's disease: A metagenomic, metatranscriptomic, and metabolomic-based study
CONCLUSION: WMT demonstrated therapeutic efficacy in CD treatment, likely due to the effective reconstruction of the patient's microbiome. Multi-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.PMID:38617453 | PMC:PMC11008410 | DOI:10.3748/wjg.v30.i11.1572 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Source Type: research
Real-World Treatment Patterns and Healthcare Resource Use for Ulcerative Colitis and Crohn's Disease in Italy
CONCLUSION: This analysis, carried-out in an Italian clinical setting, may help to optimise therapy for patients with UC and CD and provide relevant clinical practice data to inform decision-makers.PMID:38619721 | DOI:10.1007/s12325-024-02840-x (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Melania Dovizio Susanne Hartz Carlotta Buzzoni Isabel Redondo Marijana Nedeljkovic Protic Domenico Birra Valentina Perrone Chiara Veronesi Luca Degli Esposti Alessandro Armuzzi Source Type: research
