Log in to search using one of your social media accounts:

 

Acute Myeloid Leukemia Overview Video Acute Myeloid Leukemia Overview Video
This video discusses the pathophysiology and major clinical signs and symptoms of acute myeloid leukemia.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 23, 2018 Category: Consumer Health News Tags: Med Students Commentary Source Type: news

New strategy to target transcription factor STAT5 to combat leukaemia
(University of Veterinary Medicine -- Vienna) Acute myeloid leukaemia is the most common type of acute cancer of the blood and bone marrow in adults. AML progresses quickly and only 26 percent of the patients survive longer than 5 years as resistance against established treatments arises. The most common molecular cause is FLT3 mutations, which result in hyper-activation of STAT5. A researcher consortium now reports on an early preclinical development to target STAT5 directly, which cooperates well with existing therapies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 22, 2018 Category: Biology Source Type: news

Romiplostim Not Tied to Leukemic Progression in Myelodysplastic Syndromes Romiplostim Not Tied to Leukemic Progression in Myelodysplastic Syndromes
Contrary to initial reports, romiplostim treatment of thrombocytopenia does not appear to increase the risk of progression from myelodysplastic syndrome (MDS) to acute myeloid leukemia (AML).Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Quiz: Molecular Risk Stratification in Acute Myeloid Leukemia
Test your knowledge in our latest quiz. (Source: CancerNetwork)
Source: CancerNetwork - February 1, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Hematologic Malignancies Quiz Source Type: news

Enasidenib Can Cause Serious Symptoms in Some With Leukemia Enasidenib Can Cause Serious Symptoms in Some With Leukemia
A substantial minority of patients with relapsed or refractory acute myeloid leukemia (AML) show potentially deadly symptoms after treatment with enasidenib, according to a new analysis of data from an open-label trial.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Agios lines up another potential FDA nod with new leukemia drug
Less than five months after getting its first cancer drug approved, Cambridge-based Agios Pharmaceuticals has lined up another potential FDA nod — and the first for a medicine that it fully owns. Agios (Nasdaq: AGIO) said Tuesday that it had submitted an application for ivosidenib, a potential drug for patients with acute myeloid leukemia who have a specific genetic mutation, and whose cancer has relapsed or isn’t responding to initial treatment. The company said it had asked the FDA to review… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - December 26, 2017 Category: American Health Authors: Max Stendahl Source Type: news

Your NEJM Group Today: Ecthyma Gangrenosum Image / Tranexamic Acid & Epistaxis / Arizona Family Med Opportunity
Check out today's selections from NEJM Group: NEJM Clinical Practice Center: Image in Clinical Medicine: A 21-year-old woman with acute myeloid leukemia who... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 12, 2017 Category: Primary Care Source Type: news

Immunotherapy strategy could be beneficial for relapsed acute myeloid leukemia
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers will present preliminary results from an ongoing phase II trial of chemotherapy and pembrolizumab in relapsed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta on Saturday, Dec. 9. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 11, 2017 Category: Cancer & Oncology Source Type: news

Forty Seven Inc. Receives $5 Million Grant from The California Institute for Regenerative Medicine (CIRM) to Support Ongoing Clinical Trial in Acute Myeloid Leukemia
CIRM grant will support further development of Forty Seven Inc.'s CD47 antibody Hu5F9-G4 in an ongoing second trial for the treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome MENLO PARK, Calif., Dec. 6, 2017 -- (Healthcare Sales & Marketin... Biopharmaceuticals, Regenerative Medicine, Oncology Forty Seven, acute myeloid leukemia, Myelodysplastic Syndrome, stem cell (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 6, 2017 Category: Pharmaceuticals Source Type: news

State's stem cell agency awards nearly $8 million for new leukemia therapies
(University of California - San Diego) The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 1, 2017 Category: Cancer & Oncology Source Type: news

The target landscape of clinical kinase drugs
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration of phosphoproteomic data refined drug-affected pathways, identified response markers, and strengthened rationale for combination tr...
Source: ScienceNOW - November 30, 2017 Category: Science Authors: Klaeger, S., Heinzlmeir, S., Wilhelm, M., Polzer, H., Vick, B., Koenig, P.-A., Reinecke, M., Ruprecht, B., Petzoldt, S., Meng, C., Zecha, J., Reiter, K., Qiao, H., Helm, D., Koch, H., Schoof, M., Canevari, G., Casale, E., Depaolini, S. R., Feuchtinger, A. Tags: Cell Biology, Medicine, Diseases r-articles Source Type: news

Unforeseen new drug target discovered for acute myeloid leukemia
(Wellcome Trust Sanger Institute) A study reported in Nature has found an unexpected new drug target for acute myeloid leukemia that could open new avenues to develop effective treatments against this potentially lethal disease. Researchers from the Wellcome Trust Sanger Institute, the Gurdon Institute and their collaborators show that inhibiting the METTL3 gene destroys AML cells without harming non-leukemic blood cells and reveals why METTL3 is required for AML cell survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2017 Category: Cancer & Oncology Source Type: news

Are You Sure That's What the Doctor Said About Your Leukemia?
Source: HealthDay Related MedlinePlus Pages: Acute Myeloid Leukemia, Talking With Your Doctor (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 3, 2017 Category: Consumer Health News Source Type: news

Are You Sure That's What the Doctor Said About Your Leukemia?
THURSDAY, Nov. 2, 2017 -- The stress of a frightening leukemia diagnosis may impede clear doctor-patient communication, a new study suggests. Patients undergoing chemotherapy treatment for acute myeloid leukemia (AML) tend to view their illness and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 2, 2017 Category: General Medicine Source Type: news

Papers of note in Science Translational Medicine 9 (413)
This week’s articles describe new therapeutic targets for pulmonary arterial hypertension, acute myeloid leukemia, and Friedreich’s ataxia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 31, 2017 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

Blocking key pathways is a way to defeat cancer stem cells
(RIKEN) Scientists from the RIKEN Center for Integrative Medical Sciences in Japan and international collaborators have found that in humanized mice, a cocktail of drugs blocking certain key pathways is effective in eliminating acute myeloid leukemia (AML), a disease which is estimated to kill more than 250,000 people a year around the world. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 25, 2017 Category: Cancer & Oncology Source Type: news

People with leukemia and their oncologists have vastly different perceptions of prognosis
(American Society of Clinical Oncology) A study of 100 people with acute myeloid leukemia (AML) receiving chemotherapy found that patient and physician perceptions of treatment risk and the likelihood of a cure varied widely. Overall, patients tended to overestimate both the risk of dying due to treatment and the likelihood of a cure. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2017 Category: Cancer & Oncology Source Type: news

Bolstering fat cells offers potential new leukemia treatment
(McMaster University) Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a study from McMaster University published in Nature Cell Biology. Researchers with the McMaster Stem Cell and Cancer Research Institute found that boosting adipocytes, or fat cells, located in the bone morrow suppressed cancerous leukemia cells but -- in a surprise to the research team -- also induced the regeneration of healthy blood cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 16, 2017 Category: Biology Source Type: news

Novel Treatment Causes Cancer to Self-Destruct Without Affecting Healthy Cells
October 9, 2017—BRONX, NY—Scientists atAlbert Einstein College of Medicine have discovered the first compound that directly makescancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue of Cancer Cell, was directed against acute myeloid leukemia (AML) cells but may also have potential for attacking other types of cancers. (Source: Einstein News)
Source: Einstein News - October 9, 2017 Category: Universities & Medical Training Source Type: news

Novel Treatment Causes Cancer to Self-Destruct Without Affecting Healthy Cells
October 9, 2017—BRONX, NY—Scientists atAlbert Einstein College of Medicine have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue ofCancer Cell, was directed against acute myeloid leukemia (AML) cells but may also have potential for attacking other types of cancers. (Source: Einstein News)
Source: Einstein News - October 9, 2017 Category: Universities & Medical Training Source Type: news

Medical News Today: New compound kills cancer without harming healthy cells
A proof-of-concept study shows how a new compound selectively triggers cell suicide in acute myeloid leukemia cells without harming healthy cells. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 9, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Stealing from the body: How cancer recharges its batteries
(University of East Anglia) New research published today uncovers how the blood cancer 'steals' parts of surrounding healthy bone marrow cells to thrive, in work that could help form new approaches to cancer treatment in the future. Researchers at the University of East Anglia (UEA), funded by the Rosetrees Trust and The Big C Charity, found that healthy bone marrow stromal cells were made to transfer their power-generating mitochondria to neighbouring cancer cells, effectively 'recharging' the acute myeloid leukaemia (AML) and supporting the leukaemia to grow. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 5, 2017 Category: Cancer & Oncology Source Type: news

BioLineRx launches Phase Ib/II combination trial for acute myeloid leukaemia
Israeli biopharmaceutical firm BioLineRx has launched a Phase Ib/II clinical trial (BATTLE) of BL-8040 in combination with Genentech ’s anti-PDL1 immunotherapy atezolizumab (Tecentriq) in patients suffering from acute myeloid leukaemia (AML). (Source: Drug Development Technology)
Source: Drug Development Technology - September 27, 2017 Category: Pharmaceuticals Source Type: news

HLA-mismatched Microtransplant Benefits Older AML Patients HLA-mismatched Microtransplant Benefits Older AML Patients
Most older patients with newly diagnosed acute myeloid leukemia (AML) achieve complete remission and good overall survival after HLA-mismatched microtransplant, according to results from 12 centers in China, the United States, and Spain.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 20, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Novartis's Rydapt wins EU approval for AML, other diseases
ZURICH (Reuters) - Swiss drugmaker Novartis on Wednesday said it had won European Union approval for Rydapt to be used against a mutated form of acute myeloid leukemia (AML) and other rare diseases, adding to U.S. approvals it secured in April. (Source: Reuters: Health)
Source: Reuters: Health - September 20, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

MD Anderson and Daiichi Sankyo enter research collaboration to accelerate development of acute myeloid leukemia therapies
(University of Texas M. D. Anderson Cancer Center) The University of Texas MD Anderson Cancer Center and Daiichi Sankyo Company, Limited today announced a multi-year collaboration focused on accelerating the development of novel therapies for acute myeloid leukemia (AML). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2017 Category: International Medicine & Public Health Source Type: news

Inhibitors support immune therapy for leukemia
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) New immune therapies are considered a promising lead for treating recurring acute myeloid leukemia (AML). Antibodies are able to eliminate even those cancer cells that cannot be removed via regular therapies. Scientists from the German Cancer Consortium (DKTK) and the Munich University Hospital and T ü bingen University Hospital have shown that, in conjunction with certain inhibitors, this form of therapy could be successful in even more patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 12, 2017 Category: Cancer & Oncology Source Type: news

FDA approves Mylotarg to treat acute myeloid leukemia
The U.S. Food and Drug Administration approved Mylotarg, or gemtuzumab, for the treatment of adults with newly diagnosed acute myloid leukemia. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 5, 2017 Category: Consumer Health News Source Type: news

Pfizer ’s Mylotarg receives FDA approval for acute myeloid leukaemia treatment
The US Food and Drug Administration (FDA) has granted approval to Pfizer ’s antibody-drug conjugate (ADC) Mylotarg (gemtuzumab ozogamicin) for the treatment of patients with acute myeloid leukaemia (AML). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 3, 2017 Category: Pharmaceuticals Source Type: news

FDA Approves Mylotarg (gemtuzumab ozogamicin) for the Treatment of Acute Myeloid Leukemia
September 1, 2017 -- The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML). The FDA... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 1, 2017 Category: Drugs & Pharmacology Source Type: news

FDA OKs Return of Once-Withdrawn Leukemia Drug
At lower dose, Mylotarg extended survival against a certain type of blood cancer Source: HealthDay Related MedlinePlus Pages: Acute Myeloid Leukemia, Medicines (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - September 1, 2017 Category: Consumer Health News Source Type: news

Mylotarg Back on Market with New FDA Approval
(MedPage Today) -- Smaller doses OK'd for certain acute myeloid leukemia indications (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - September 1, 2017 Category: American Health Source Type: news

Mylotarg Approved for AML: Drug Returns to Market Mylotarg Approved for AML: Drug Returns to Market
After being voluntarily withdrawn 7 years ago, gemtuzumab ozogamicin (Mylotarg) is now returning to the market for the treatment of acute myeloid leukemia.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 1, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA OKs Return of Once-Withdrawn Leukemia Drug, Mylotarg
FRIDAY, Sept. 1, 2017 -- The U.S. Food and Drug Administration on Friday approved an altered dose of the drug Mylotarg to treat a distinctive type of acute myeloid leukemia -- CD33-positive AML. An earlier version of the drug had been withdrawn... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 1, 2017 Category: General Medicine Source Type: news

FDA approves Pfizer's leukemia drug
(Reuters) - The U.S. Food and Drug Administration (FDA) on Friday approved Pfizer Inc's drug, Mylotarg, for certain patients with acute myeloid leukemia (AML). (Source: Reuters: Health)
Source: Reuters: Health - September 1, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

FDA approves Mylotarg for treatment of acute myeloid leukemia
SILVER SPRING, Md., Sept. 1, 2017 -- (Healthcare Sales & Marketing Network) -- The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors expres... Biopharmaceuticals, Oncology, FDA Pfizer, Mylotarg, gemtuzumab ozogamicin, acute myeloid leukemia (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 1, 2017 Category: Pharmaceuticals Source Type: news

FDA approves Mylotarg for treatment of acute myeloid leukemia
The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML). The FDA also approved Mylotarg for the treatment of patients aged 2 years and older with CD33-positive AML who have experienced a relapse or who have not responded to initial treatment (refractory). (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 1, 2017 Category: American Health Source Type: news

FDA approves Mylotarg for treatment of acute myeloid leukemia
The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML). The FDA also approved Mylotarg for the treatment of patients aged 2 years and older with CD33-positive AML who have experienced a relapse or who have not responded to initial treatment (refractory). (Source: World Pharma News)
Source: World Pharma News - September 1, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Medical News Today: Acute myeloid leukemia: Heart drugs may boost chemotherapy
Researchers find that drugs normally used to treat heart and blood vessel disease could also help to improve chemotherapy outcomes for patients with AML. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 31, 2017 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Astellas starts dosing gilteritinib patients in Phase III trial to treat AML
Astellas Pharma has started dosing patients with gilteritinib in a Phase III MORPHO clinical trial for the treatment of acute myeloid leukaemia (AML). (Source: Drug Development Technology)
Source: Drug Development Technology - August 22, 2017 Category: Pharmaceuticals Source Type: news

Vitamin C injections could play a role in treating blood cancers
Conclusion This mouse study explored whether treatment with vitamin C could restore function of TET2 and therefore block the progression of blood cancers like leukaemia. It found that using high doses of vitamin C intravenously did in fact suppress the growth of leukaemia cancer stem cells in the mice implanted with cell lines from human patients with leukaemia. It also reported that using vitamin C alongside existing treatment with PARP inhibitors helped reduce the progressions of the disease. The researchers suggest that in the future, vitamin C could be used alongside chemotherapy and other conventional treatment forms....
Source: NHS News Feed - August 21, 2017 Category: Consumer Health News Tags: Cancer Source Type: news

Idhifa (enasidenib) for the Treatment of Acute Myeloid Leukaemia (AML)
Idhifa (enasidenib) is an isocitrate dehydrogenase 2 (IDH2) enzyme inhibitor indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukaemia (AML). (Source: Drug Development Technology)
Source: Drug Development Technology - August 17, 2017 Category: Pharmaceuticals Source Type: news

FDA grants orphan drug status to H3 Biomedicine ’s cancer treatment H3B-8800
H3 Biomedicine, a member of Eisai ’s global Oncology Business Group, has received orphan drug designation from the US Food and Drug Administration (FDA) for its H3B-8800, a clinical compound used to treat patients with acute myelogenous leukaemia (AML… (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 15, 2017 Category: Pharmaceuticals Source Type: news

Drug hope for acute myeloid leukemia
(University of Bradford) A new drug that strips cancer cells of their 'immortality' could help to treat patients suffering from one of the most aggressive forms of leukemia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 8, 2017 Category: Cancer & Oncology Source Type: news

FDA approves Jazz Pharmaceutical ’ s liposomal AML chemotherapy
Jazz Pharmaceuticals (NSDQ:JAZZ) said today that the FDA approved its Vyxeos injectable liposome for the treatment of adults with two types of acute myeloid leukemia. Vyxeos is the first product designed with the Dublin-based company’s CombiPlex technology, delivering a fixed-ratio of daunorubicin and cytarabine to a patient’s bone marrow. Get the full story at our sister site, Drug Delivery Business News. The post FDA approves Jazz Pharmaceutical’s liposomal AML chemotherapy appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - August 7, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Food & Drug Administration (FDA) Oncology Pharmaceuticals Wall Street Beat jazzpharmaceuticals Source Type: news

D.C. Week: FDA User Fee Reauthorization Passes Congress
(MedPage Today) -- Also, FDA approves new treatments for acute myeloid leukemia (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 5, 2017 Category: American Health Source Type: news

FDA Approves Combination for Therapy-Related Acute Myeloid Leukemia
The FDA has approved a fixed combination of cytarabine and daunorubicin (Vyxeos) for the treatment of newly diagnosed therapy-related acute myeloid leukemia (AML) as well as AML with myelodysplasia-related changes. (Source: CancerNetwork)
Source: CancerNetwork - August 4, 2017 Category: Cancer & Oncology Authors: Ian Ingram Tags: Hematologic Malignancies Leukemia & Lymphoma News Source Type: news

Medical News Today: Leukemia breakthrough: Blood molecule key to treating AML
Heme, a chemical structure found in hemoglobin, is key to treating acute myeloid leukemia, an aggressive form of blood cancer, researchers have discovered. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 4, 2017 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

New Treatment Approved for Acute Myeloid Leukemia
Title: New Treatment Approved for Acute Myeloid LeukemiaCategory: Health NewsCreated: 8/3/2017 12:00:00 AMLast Editorial Review: 8/4/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - August 4, 2017 Category: Cancer & Oncology Source Type: news

FDA Approves New Treatment for Acute Myeloid Leukemia
Vyxeos combines two previously approved drugs - - daunorubicin and cytarabine (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - August 4, 2017 Category: Cancer & Oncology Tags: Oncology, Pharmacy, Institutional, Source Type: news