Study Supports Chemopreventive Effect of Statins on Liver Cancer in NASH Cirrhosis Study Supports Chemopreventive Effect of Statins on Liver Cancer in NASH Cirrhosis
New research provides supporting evidence for chemopreventive effects of statins on hepatocellular carcinoma in patients with nonalcoholic steatohepatitis cirrhosis.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 20, 2021 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

COVID-19 mRNA Vaccine Reduces Infections in Cirrhosis Patients
MONDAY, July 19, 2021 -- Although the immune response is slow and the level of protection against infection is modest, mRNA vaccine reduces COVID-19-related hospitalizations and deaths in patients with cirrhosis, according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 19, 2021 Category: Pharmaceuticals Source Type: news

RNA modification may protect against liver disease, explain liver fat differences between sexes
FINDINGSA chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells ’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of fat in the liver and can lead to advanced liver disease, according to a new study by UCLA researchers.The study, conducted in mice, also suggests that this modification — known as m6A, in which a methyl group attaches to an RNA chain — may occurat a different ratein femalesthan it does inmales, potentially explaining why females tend to have higher fat content in ...
Source: UCLA Newsroom: Health Sciences - July 19, 2021 Category: Universities & Medical Training Source Type: news

Fatty liver disease: Feeling weak or confused could signal something wrong with your liver
FATTY liver disease: Many people are symptom-free for years as it develops into a more serious illness. Once the liver becomes scarred or cirrhosis develops, it stops functioning as well, and that's when people may begin to notice symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - July 19, 2021 Category: Consumer Health News Source Type: news

Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis, BMJ Open
This retrospective cohort study of US veterans (n=40,074) found that 1 dose of mRNA vaccine administration of either vaccine was associated with a 64.8% reduction in COVID-19 infections and 100% reduction in hospitalisation or death due to COVID-19 infection after 28 days (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 15, 2021 Category: Consumer Health News Source Type: news

Selective, toxin-bearing antibodies could help treat liver fibrosis
(University of California - San Diego) UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 12, 2021 Category: International Medicine & Public Health Source Type: news

Liver Cirrhosis Much More Deadly for Black Americans
FRIDAY, June 25, 2021 -- Black Americans with cirrhosis— late-stage liver disease— are much less likely to receive a liver transplant and more likely to die than white patients, new research reveals. For the study, researchers at... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 25, 2021 Category: General Medicine Source Type: news

Black patients with cirrhosis more likely to die, less likely to get liver transplant
(Northwestern University) Black patients with cirrhosis - late-stage liver disease - are about 25% more likely to die compared to non-Hispanic white patients and four times less likely to receive a liver transplant, reports a new study. Estimates of racial disparity in cirrhosis have been limited by a lack of large-scale longitudinal data. The paper is one of the first to link all seven large liver centers in Chicago with the death registry and transplant registry to examine racial disparities in cirrhosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 23, 2021 Category: International Medicine & Public Health Source Type: news

Children of obese mums at higher risk of fatty liver disease – study
Researchers say influences in the womb may play a role in increasing the risk of developing the conditionChildren of obese mothers have a greater risk of developing fatty liver disease in their 20s, according to researchers who say policymakers need to do more to tackle the promotion of poor-quality food and drink.Non-alcoholic fatty liver disease (NAFLD) can becaused by obesity. If it progresses it can lead to serious health problems such as cirrhosis and liver cancer, while high levels of fat in the liver are also associated with a greater risk of type 2 diabetes and heart disease.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - June 20, 2021 Category: Science Authors: Nicola Davis Tags: Medical research Obesity Health Science Society Source Type: news

Fatty liver disease symptoms: Eight sensations indicating your organ is severely damaged
FATTY liver disease can progress to cirrhosis - scarring of the organ. This is where healthy tissue is replaced by scar tissue, preventing the liver from functioning well. (Source: Daily Express - Health)
Source: Daily Express - Health - June 19, 2021 Category: Consumer Health News Source Type: news

The Evolving Challenge of Infections in Cirrhosis
Approximately two thirds of patients with cirrhosis and extrahepatic organ failure have sepsis. Review covers pathogenesis, recognition and treatment of infections, critical care management, prevention of infections, and emerging approaches to management. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 18, 2021 Category: Consumer Health News Source Type: news

A simple blood test to identify patients at risk of nonalcoholic fatty liver disease
(Osaka University) Researchers from Osaka University, along with international collaborators in Europe, have identified Thrombospondin-2 as a serum biomarker that confirms and stratifies the progressive complications of nonalcoholic fatty liver disease. This research may form the basis of a new noninvasive approach that can provide an early warning system for nonalcoholic steatohepatitis and advanced fibrosis and may predict progression to cirrhosis, liver failure and even cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 16, 2021 Category: Cancer & Oncology Source Type: news

Fatty liver disease: Early warning risks could include unusual bleeding - like nosebleeds
FATTY liver disease: For cirrhosis to develop, long-term, continuous damage to the liver needs to occur. This continuous damage can lead to a variety of major health conditions which could be fatal. An early sign of the disease includes epistaxis. (Source: Daily Express - Health)
Source: Daily Express - Health - June 14, 2021 Category: Consumer Health News Source Type: news

Fatty liver disease symptoms: The texture of your poo can indicate if your organ is damage
A FATTY liver, when inflamed, can lead to vague symptoms such as tiredness and discomfort in the upper abdomen. However, if the condition continues to progress to cirrhosis , the texture of your poo can be revealing. (Source: Daily Express - Health)
Source: Daily Express - Health - June 6, 2021 Category: Consumer Health News Source Type: news

Due to risk of serious liver injury, FDA restricts use of Ocaliva (obeticholic acid) in primary biliary cholangitis (PBC) patients with advanced cirrhosis
; adding and updating warnings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 3, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Restricts Obeticholic Acid Over Serious Liver Injury Risk FDA Restricts Obeticholic Acid Over Serious Liver Injury Risk
Obeticholic acid is now contraindicated in patients with primary biliary cholangitis and advanced cirrhosis, following reports of serious liver injury leading to liver decompensation or liver failure.News Alerts (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - May 26, 2021 Category: Gastroenterology Tags: Gastroenterology News Alert Source Type: news

Ocaliva (obeticholic acid) by Intercept Pharmaceuticals: Drug Safety Communication - Due to Risk of Serious Liver Injury, FDA Restricts Use of Ocaliva in Primary Biliary Cholangitis Patients with Advanced Cirrhosis
FDA is restricting the use of the liver disease medicine Ocaliva (obeticholic acid) in patients having primary biliary cholangitis with advanced cirrhosis of the liver because some patients with cirrhosis who took Ocaliva, especially those with evidence of advanced cirrhosis, developed liver failure (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 26, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Due to risk of serious liver injury, FDA restricts use of Ocaliva in primary biliary cholangitis (PBC) patients with advanced cirrhosis
; adding and updating warnings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 26, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Gut check
(Harvard Medical School) Researchers identify links between genetic makeup of bacteria in human gut and several human diseases. Clusters of bacterial genes present in conditions including cardiovascular illness, inflammatory bowel disease, liver cirrhosis, and cancer. Work brings scientist closer to developing tests that could predict disease risk or identify disease presence based on a sampling of the genetic makeup of a person's microbiome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2021 Category: International Medicine & Public Health Source Type: news

Suvorexant poisoning in a patient with cirrhosis and renal failure - Ito H, Ogawa Y, Shimojo N, Kawano S.
Suvorexant is a novel hypnotic that acts as an orexin-1 receptor and orexin-2 receptor antagonist. Owing to its safety and tolerability, suvorexant has recently become widely used. However, little is known about the presentation of suvorexant poisoning. He... (Source: SafetyLit)
Source: SafetyLit - May 12, 2021 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Fatty liver disease: The texture of your faeces could signal organ damage
FATTY liver disease progresses through four stages: steatosis, steatohepatitis, fibrosis, and cirrhosis. Most people are unlikely to experience symptoms until the liver is struggling to function. (Source: Daily Express - Health)
Source: Daily Express - Health - May 9, 2021 Category: Consumer Health News Source Type: news

Bariatric Surgery and Alcohol-Related Cirrhosis/Alcohol Misuse Bariatric Surgery and Alcohol-Related Cirrhosis/Alcohol Misuse
Does bariatric surgery impact the subsequent risk of alcohol misuse and alcohol-related cirrhosis?Liver International (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - May 7, 2021 Category: Surgery Tags: Gastroenterology Journal Article Source Type: news

Fatty liver disease symptoms: The key physical indication your organ is damaged
EXCESS fat stored in the liver can result in organ damage, which can reduce its capability to perform multiple life-supporting functions. Scarring of the liver, known as cirrhosis, may lead to symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - April 30, 2021 Category: Consumer Health News Source Type: news

Portopulmonary hypertension in patients with chronic liver disease
(Shinshu University) Portopulmonary hypertension (PoPH) is a form of pulmonary arterial hypertension (PAH). PoPH occurs in approximately 15% of patients with PAH, and is reportedly found in 2-6% of patients with portal hypertension and 1-2% of patients with liver cirrhosis according to studies from Europe and America. However, the real-world data on PoPH in Japan are largely unknown, with many questions on the condition's etiology and prevalence. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2021 Category: International Medicine & Public Health Source Type: news

Falls are common, morbid, and predictable in patients with cirrhosis - Tapper EB, Nikirk S, Parikh N, Zhao L.
BACKGROUND: Falls are a devastating complication of cirrhosis. The risk of falls in contemporary patients without HE is unclear. Further, bedside tools for predicting falls are lacking METHODS: We prospectively enrolled 299 subjects with currently compensa... (Source: SafetyLit)
Source: SafetyLit - April 26, 2021 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The efficacy of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: a protocol for systematic review and meta-analysis - Wang N, Yao W, Ma R, Ren F.
OBJECTIVE: The effect of probiotics on cognitive function and the risk of falling in cirrhosis patients have not been previously evaluated. We perform this protocol for systematic review and meta-analysis to evaluate the effect of a multistrain probiotic o... (Source: SafetyLit)
Source: SafetyLit - April 23, 2021 Category: International Medicine & Public Health Tags: Falls Source Type: news

Non-alcoholic fatty liver disease symptoms: Three symptoms that signal 'permanent' damage
NON-ALCOHOLIC fatty liver disease often goes undetected until it progresses to cirrhosis. What is cirrhosis and what are the symptoms to expect? (Source: Daily Express - Health)
Source: Daily Express - Health - April 13, 2021 Category: Consumer Health News Source Type: news

Genetic Risk Factors for Cirrhosis in Hemochromatosis Genetic Risk Factors for Cirrhosis in Hemochromatosis
This study identified gene variants which modulate the cirrhosis risk in hereditary hemochromatosis.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Primary Biliary Cirrhosis (PBC) Treatment
Title: Primary Biliary Cirrhosis (PBC) TreatmentCategory: Diseases and ConditionsCreated: 8/21/2001 12:00:00 AMLast Editorial Review: 3/29/2021 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - March 29, 2021 Category: Nutrition Source Type: news

Patients With Decompensated Cirrhosis Often Lack Advance Care Plans Patients With Decompensated Cirrhosis Often Lack Advance Care Plans
Many patients with decompensated cirrhosis do not have advance care plans in place to cover their trajectory of illness through end-of-life care, according to a new study that concludes this may be one reason they receive overly aggressive treatment.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 17, 2021 Category: Transplant Surgery Tags: Gastroenterology News Source Type: news

Fatty liver disease symptoms: Six signs your condition has become irreversible
FATTY liver disease is pernicious because warning signs may only emerge in the later stages. If fatty liver disease progresses to cirrhosis , it cannot be reversed. Here are six warning signs of cirrhosis. (Source: Daily Express - Health)
Source: Daily Express - Health - March 16, 2021 Category: Consumer Health News Source Type: news

Targeted Albumin Not Better for Hospitalized Cirrhosis Patients
MONDAY, March 8, 2021 -- For patients hospitalized with decompensated cirrhosis, albumin infusions to raise the serum albumin level to a target of 30 g per liter or higher do not improve outcomes compared with standard care, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 8, 2021 Category: Pharmaceuticals Source Type: news

New AASLD Guidelines Reconsider Bleeding Risk in Cirrhosis New AASLD Guidelines Reconsider Bleeding Risk in Cirrhosis
Dr David Johnson comments on the paradigm-shifting implications of these guidelines on coagulation and bleeding in patients with cirrhosis.Medscape Gastroenterology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - March 4, 2021 Category: Intensive Care Tags: Gastroenterology Commentary Source Type: news

Oncotarget: Effect of liver fibrosis on survival in patients with intrahepatic cholangiocarcinoma
(Impact Journals LLC) The @Oncotarget authors aimed to assess the effect of cirrhosis on outcomes in iCCA patients (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 1, 2021 Category: Cancer & Oncology Source Type: news

Thiazolidinediones and Risk of MACE in T2DM and Cirrhosis Thiazolidinediones and Risk of MACE in T2DM and Cirrhosis
This study investigated the long-term cardiovascular outcomes of thiazolidinedione use in patients with type 2 diabetes and cirrhosis.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Operational guidelines launched for integration of Non-Alcoholic Fatty Liver Disease with NPCDCS
"Over the last two decades global burden of NASH has more than doubled. Globally, NASH caused 40 lakh prevalent cases of compensated cirrhosis in 1990, which increased to 94 lakh cases in 2017. NAFLD is emerging as an important cause of liver disease in India," Vardhan was quoted as saying in a Health Ministry statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 22, 2021 Category: Pharmaceuticals Source Type: news

AGA Practice Update: Bariatric Surgery in Patients With Cirrhosis AGA Practice Update: Bariatric Surgery in Patients With Cirrhosis
According to one study cited in the update, approximately 30% of patients with cirrhosis have comorbid obesity, and this figure may increase even further as the epidemic of NAFLD progresses.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - February 8, 2021 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

As alcohol abuse rises amid pandemic, hospitals see a wave of deadly liver disease
UCLA, USC and hospitals nationwide are treating more patients for alcoholic hepatitis, cirrhosis and other conditions amid COVID-19 shutdowns. (Source: L.A. Times - Health)
Source: L.A. Times - Health - February 8, 2021 Category: Consumer Health News Authors: Eli Cahan Source Type: news

Rifaximin May Prevent Hepatic Encephalopathy After TIPS Placement for Cirrhosis Rifaximin May Prevent Hepatic Encephalopathy After TIPS Placement for Cirrhosis
The antibiotic rifaximin given before and after transjugular intrahepatic portosystemic shunt (TIPS) placement helped prevent hepatic encephalopathy (HE) in a placebo-controlled trial.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - February 6, 2021 Category: Surgery Tags: Gastroenterology News Source Type: news

New combination therapy offers chance of healing hepatitis B
(German Center for Infection Research) Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 4, 2021 Category: Infectious Diseases Source Type: news

Rifaximin Prevents Overt Hepatic Encephalopathy After TIPS
MONDAY, Feb. 1, 2021 -- For patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS) placement, rifaximin used before and after the procedure is associated with a reduced risk for overt hepatic encephalopathy (HE),... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 1, 2021 Category: Pharmaceuticals Source Type: news

Fatty liver disease symptoms: Melena is a sign of the condition
FATTY liver disease could progress to cirrhosis - scarring of the liver - if fat cells continue to build up in the life-supporting organ. How do you know if you're affected by the condition? What are the symptoms? (Source: Daily Express - Health)
Source: Daily Express - Health - January 30, 2021 Category: Consumer Health News Source Type: news

Widespread Liver Disease Missed in Patients With Type 2 Diabetes Widespread Liver Disease Missed in Patients With Type 2 Diabetes
Strikingly high prevalence rates of fatty liver disease, advanced fibrosis, and cirrhosis among patients with type 2 diabetes has led to calls for heightened awareness and screening.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - January 25, 2021 Category: Gastroenterology Tags: Diabetes & Endocrinology News Source Type: news

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
(American Roentgen Ray Society) According to ARRS' American Journal of Roentgenology, Fibrosis-4 and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis remains elusive on CT. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2021 Category: Cancer & Oncology Source Type: news

Terlipressin Has Stood the Test of Time Terlipressin Has Stood the Test of Time
This paper details the pharmacokinetics, pharmacodynamics and recent studies on the safety and efficacy of the investigational drug terlipressin in patients with cirrhosis.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 21, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Terlipressin Has Stood the Test of Time Terlipressin Has Stood the Test of Time
This paper details the pharmacokinetics, pharmacodynamics and recent studies on the safety and efficacy of the investigational drug terlipressin in patients with cirrhosis.Liver International (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 21, 2021 Category: Intensive Care Tags: Gastroenterology Journal Article Source Type: news

SARS-CoV-2 vaccination in patients with liver disease: responding to the next big question, Lancet Gastroenterology and Hepatology
Amongst other points, article highlights that patients with cirrhosis are likely to have attenuated immune responses with vaccination. Nonetheless, given the high COVID-19-related mortality in these patients, it remains important to prioritise vaccination in this subgroup. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 13, 2021 Category: Consumer Health News Source Type: news

In Cirrhosis, Women Have Worse Frailty Scores Than Men
MONDAY, Jan. 4, 2021 -- Among patients with cirrhosis, women have worse frailty scores than men, which accounts for part of the gender gap in mortality while awaiting liver transplantation, according to a study published online Dec. 30 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 4, 2021 Category: Pharmaceuticals Source Type: news

Association between new-onset liver cirrhosis and suicide risk in South Korea: a nationwide cohort study - Jang SY, Rou WS, Kim SH, Lee BS, Eun HS.
Background& Aims: Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is kno... (Source: SafetyLit)
Source: SafetyLit - December 21, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Fibroscan Liver Stiffness After Anti-viral Treatment for HCV Fibroscan Liver Stiffness After Anti-viral Treatment for HCV
This study investigated whether liver stiffness pre- or post-anti-viral therapy is associated with the development of decompensated cirrhosis, hepatocellular carcinoma, or death.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 16, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news