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Cirrhosis Is a Risk Factor for Atrial Fibrillation Cirrhosis Is a Risk Factor for Atrial Fibrillation
Is cirrhosis an independent risk factor for development of atrial fibrillation?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 10, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

An App to Prevent Hepatic Encephalopathy-related Readmissions An App to Prevent Hepatic Encephalopathy-related Readmissions
Can an easy-to-use mobile app which focuses on hepatic encephalopathy, ascites, and fall prevention help reduce readmissions in patients with cirrhosis?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 29, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Scientists discover a mutation could cause bad breath
Scientists from the University of California, Davis, believe it is important to identify the cause of persistent bad breath as it could be gum disease or, in more serious cases, liver cirrhosis. (Source: the Mail online | Health)
Source: the Mail online | Health - December 20, 2017 Category: Consumer Health News Source Type: news

What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Simeprevir + Daclatasvir in HCV GT1b With Advanced Disease Simeprevir + Daclatasvir in HCV GT1b With Advanced Disease
This study investigated the efficacy and safety of simeprevir plus daclatasvirin in a population of treatment-naive patients with chronic GT1b HCV infection with advanced fibrosis or cirrhosis.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Primary Biliary Cirrhosis
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 12, 2017 Category: General Medicine Source Type: news

YouTube star Angry Grandpa dies aged 67 of cirrhosis
Charles Marvin Green Jr., also known as Angry Grandpa, of Summerville, South Carolina, died on Sunday five months after being diagnosed with cirrhosis, his son Michael announced. (Source: the Mail online | Health)
Source: the Mail online | Health - December 11, 2017 Category: Consumer Health News Source Type: news

A South American amphibian could potentially hold the key in curing cirrhosis
(University of Surrey) The unique liver function of a South American amphibian, Siphonops annulatus, could pave the way to finding a cure to the devastating liver condition cirrhosis, a new study published in the prestigious Journal of Anatomy reports. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 6, 2017 Category: International Medicine & Public Health Source Type: news

Galectin slumps after NASH drug misses main goal of mid-stage trial
(Reuters) - Galectin Therapeutics Inc said its drug for the complex progressive fatty liver disease NASH led to some clinically meaningful results in patients with cirrhosis, but failed to achieve the main goal of a mid-stage trial, sending its shares plunging 48 percent on Tuesday. (Source: Reuters: Health)
Source: Reuters: Health - December 5, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Galectin says NASH drug misses main goal of midstage trial
(Reuters) - Galectin Therapeutics Inc said on Tuesday its experimental drug for the complex progressive fatty liver disease NASH led to some clinically meaningful results in patients with cirrhosis, but failed to achieve the main goal of a midstage trial. (Source: Reuters: Health)
Source: Reuters: Health - December 5, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

FDA Approves MRI Software for Fatty Liver Disease Screening FDA Approves MRI Software for Fatty Liver Disease Screening
The diagnosis of nonalcoholic fatty liver disease, which can rapidly progress to cirrhosis or liver cancer, could become easier with new multiparametric MRI software.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 4, 2017 Category: Consumer Health News Tags: Radiology News Source Type: news

Bad breath warning: These FIVE hidden health problems could be REVEALED by foul smell
BAD BREATH is unpleasant, but it could also be a sign of an underlying health condition, such as kidney disease or cirrhosis, says an expert. (Source: Daily Express - Health)
Source: Daily Express - Health - November 22, 2017 Category: Consumer Health News Source Type: news

Developing a New Score: How Machine Learning Improves Risk Prediction
Composite risk scores have been used for decades to identify disease risk and health status in the general population. However, current approaches often fail to identify people who would benefit from intervention or recommend unnecessary intervention. Machine learning promises to improve accuracy, ensuring targeted treatment for patients that need it and reducing unnecessary intervention. Framingham Risk Score, the gold standard for predicting the likelihood of heart disease, predicts hospitalizations with about 56% accuracy. It uses factors such as age, gender, smoking, cholesterol levels, and systolic blood pre...
Source: MDDI - November 17, 2017 Category: Medical Devices Authors: Heather R. Johnson Tags: R & D Source Type: news

Report suggests association between coffee and up to 70 percent reduced risk of liver disease
(Kaizo) A new roundtable report from the Institute for Scientific Information on Coffee (ISIC) in association with the British Liver Trust, on 'Looking after the liver: coffee, caffeine and lifestyle factors' highlights the potential role of coffee consumption in reducing the risk of liver diseases such as liver cancer and cirrhosis, with some studies reporting risk reduction of up to 70% (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2017 Category: Cancer & Oncology Source Type: news

US elastography for liver evaluation: Worth the cost?
Ultrasound elastography is a relatively new technology that can noninvasively...Read more on AuntMinnie.comRelated Reading: Elastography, color Doppler US avoid breast biopsies Elastography can help evaluate carotid plaque Shear-wave elastography spots Achilles tendinopathy Spleen stiffness correlates with cirrhosis complication Elastography aids assessment of focal prostate lesions (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 13, 2017 Category: Radiology Source Type: news

Statins, Decompensation, and Death in Alcoholic Cirrhosis Statins, Decompensation, and Death in Alcoholic Cirrhosis
Does regular use of statins improve outcomes and reduce mortality in patients with alcoholic cirrhosis?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 9, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

New study identifies targets to lessen the effects of alcoholic liver disease
(Elsevier) Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer. A new study in The American Journal of Pathology offers insights into the cellular aging that may trigger excessive fibrosis formation in the liver as well as possible means to inhibit these changes, which may lead to new therapeutic approaches for patients with ALD. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 8, 2017 Category: Biology Source Type: news

Living with NASH: An Unexpected Diagnosis
As our waistlines thicken and our activity levels decrease, another chronic illness threatens to disturb our comfortable lifestyles. And, because it ’s relatively unknown, diagnosis comes as a shock to patients, who usually associate liver disease with heavy consumption of alcohol.Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD), where fat accumulates in the liver. It is most commonly associated with obesity, insulin resistance, metabolic syndrome and/or genetic polymorphisms, and is aggravated by inflammation and fibrosis.  First identified in the 1980s, its ...
Source: EyeForPharma - November 3, 2017 Category: Pharmaceuticals Authors: Mariel Metcalfe Source Type: news

Mortality Rates for Overdose Patients Who Refuse Transport
This study was published March 28, 2016. The data obtained was from 2011-2013. Oh, how quickly things change in the drug trade. The Centers for Disease Control (CDC) reported the number of opioid-related deaths in 2014 was a 9% increase from the previous year.1 The illegal drug trade changes every day. More potent forms of opioids are being manufactured, and with that, more deaths occur. (Source: JEMS Patient Care)
Source: JEMS Patient Care - November 2, 2017 Category: Emergency Medicine Authors: Keith Wesley, MD, FACEP, FAEMS Tags: Patient Care Columns Source Type: news

The importance of addressing poor nutrition in patients with liver failure
(Wiley) Poor nutrition is common in patients with liver failure, or cirrhosis, and it can lead to muscle wasting, weakness, fatigue, and worse outcomes before and after patients undergo liver transplantation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 26, 2017 Category: International Medicine & Public Health Source Type: news

Burden of Cirrhosis Higher with Alcoholism (CME/CE)
(MedPage Today) -- One-third of patients account for half of cirrhosis costs (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 23, 2017 Category: Gastroenterology Source Type: news

Can Aspirin Stop Liver Cancer in Hepatitis B Patients?
FRIDAY, Oct. 20, 2017 -- Daily aspirin may reduce the risk of liver cancer for people with hepatitis B infection, a new study suggests. Hepatitis B virus attacks the liver and can cause cirrhosis and liver cancer. Previous research suggests daily... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 20, 2017 Category: General Medicine Source Type: news

Visceral Adipose Tissue Index IDs Risk of HCC in Cirrhosis
High VATI is also linked to risk of HCC recurrence in males with HCC who underwent liver transplant (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - October 18, 2017 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Internal Medicine, Oncology, Pathology, Journal, Source Type: news

Ethiopia: Sustaining HBV Intervention Success Stories
[Ethiopian Herald] Viral hepatitis result in a potentially life-threatening inflammation of the liver, which is characterized by complications of liver disease. Specifically, hepatitis B (HBV) and C (HCV) viruses alone cause chronic viral hepatitis which is a major global health problem responsible for 57_per cent of liver cirrhosis and 75_per cent of primary liver cancer cases, respectively. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 11, 2017 Category: African Health Source Type: news

Worse than liquor for your liver
Most people think liver disease only happens to alcoholics. But the truth is that being overweight or obese actually puts you at a much higher risk for liver damage than alcohol. In fact, alcohol contributes to only 6% of liver damage. But obesity contributes to 52% of liver disease. And if you’re obese, you’re 400% more likely to develop liver damage than a normal-weight individual.1 That’s why about 30% of people in America have some form of chronic fatty liver disease. It’s called non-alcoholic fatty liver disease (NAFLD). NAFLD causes painful swelling and scarring of the liver.  And I blame...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Health Weight Loss Source Type: news

Raised serum lactate in a cirrhotic patient presenting after a trivial fall - Ayeko OM, Barrow J, Ayeko MO.
We present the case of a pelvic fracture in a 69-year-old man with Child-Pugh class C cirrhosis who presented to the Accident and Emergency department after a slip on wet grass. After initially being systemically well, he became haemodynamically unstable i... (Source: SafetyLit)
Source: SafetyLit - October 4, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

QuickStats: Death Rates for Chronic Liver Disease and Cirrhosis, by Sex and Age Group — National Vital Statistics System, United States, 2000 and 2015
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 28, 2017 Category: American Health Source Type: news

Three or more cups of coffee daily halves mortality risk in patients with both HIV and HCV
(Elsevier) Patients infected by both HIV and hepatitis C virus are at specific risk of end-stage liver disease and greater risk of cardiovascular diseases and cancer. In addition, HIV infection accelerates the progression of chronic hepatitis C to fibrosis and development of cirrhosis and end-stage liver disease. In these HIV-HCV co-infected patients, drinking at least three cups of coffee each day halved the risk of all-cause mortality according to a new study published in the Journal of Hepatology. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 25, 2017 Category: Infectious Diseases Source Type: news

Statin Use Tied to Lower Mortality in Alcoholic Cirrhosis Statin Use Tied to Lower Mortality in Alcoholic Cirrhosis
Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - September 20, 2017 Category: Gastroenterology Tags: Diabetes & Endocrinology News Source Type: news

Is There a Standard for Surgical Therapy of HCC? Is There a Standard for Surgical Therapy of HCC?
This study compared different guidelines regarding indication for resection and transplantation in patients with hepatocellular carcinoma, with and without underlying cirrhosis. Is there a consensus?BMJ Open Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 13, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Drinks industry accused of downplaying 'alcohol-cancer risk'
Conclusion This qualitative analysis aimed to determine the accuracy of health information circulated by the alcohol industry on the links between alcohol and cancer. It found the industry and affiliated organisations use three main approaches: denial of the link between alcohol and cancer misinterpretation of the risk distraction by focusing on other risk factors This analysis highlights how these strategies could be detrimental to public health. Of course, it's possible, given this data was collected in 2016, that some of the websites and documents analysed by the researchers have since been updated. Regardless, the...
Source: NHS News Feed - September 8, 2017 Category: Consumer Health News Tags: Cancer Source Type: news

Statins slash the risk of death from cirrhosis by half
Researchers from the University Hospital of Hvidovre in Denmark found statins reduce the risk of dying from the alcohol-related disorder by 43 per cent but doctors are reluctant to prescribe them. (Source: the Mail online | Health)
Source: the Mail online | Health - September 7, 2017 Category: Consumer Health News Source Type: news

Alcoholic Cirrhosis Linked to Increased Admissions, Costs
Compared with non - alcoholic cirrhosis, excess 30 - day readmissions total 29.2 per 100 patients (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - September 1, 2017 Category: Psychiatry Tags: Family Medicine, Geriatrics, Gastroenterology, Internal Medicine, Critical Care, Nursing, Pathology, Psychiatry, Journal, Source Type: news

Cirrhosis
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - August 31, 2017 Category: General Medicine Source Type: news

Shorter Anti-HCV Regimen Effective in Patients With or Without Cirrhosis Shorter Anti-HCV Regimen Effective in Patients With or Without Cirrhosis
An eight-week regimen containing grazoprevir-ruzasvir-uprifosbuvir appears to be effective for treating hepatitis C virus (HCV) infection in patients with or without cirrhosis, according to findings from a pair of randomized phase 2 open-label trials.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 21, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Alcohol warning: THIS trendy spice can protect you from liver disease caused by drinking
ALCOHOL consumed in large amounts is the main cause in the Western world of liver disease, which includes fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis. However, a popular spice may provide a beneficial effect if you ’ve overdone the drinking. (Source: Daily Express - Health)
Source: Daily Express - Health - August 15, 2017 Category: Consumer Health News Source Type: news

TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that ranges in severity from hepatic steatosis to steatohepatitis, the latter of which is a major predisposing factor for liver cirrhosis and cancer. Toll-like receptor (TLR) signaling, which is critical for innate immunity, is generally believed to aggravate disease progression by inducing inflammation. Unexpectedly, we found that deficiency in TIR domain–containing adaptor-inducing interferon-β (TRIF), a cytosolic adaptor that transduces some TLR signals, worsened hepatic steatosis induced by a high-fat diet (HFD) and that such exacerbati...
Source: Signal Transduction Knowledge Environment - August 8, 2017 Category: Science Authors: Chen, J., Li, J., Yiu, J. H. C., Lam, J. K. W., Wong, C.-M., Dorweiler, B., Xu, A., Woo, C. W. Tags: STKE Research Articles Source Type: news

FDA OKs 8-Week Mavyret for Hepatitis C FDA OKs 8-Week Mavyret for Hepatitis C
Glecaprevir/pibrentasvir is the first HCV treatment of this duration approved for genotypes 1 through 6 in previously untreated adults without cirrhosis.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2017 Category: Consumer Health News Tags: Gastroenterology News Alert Source Type: news

FDA Approves Mavyret (glecaprevir and pibrentasvir) for Hepatitis C
August 3, 2017 -- The U.S. Food and Drug Administration today approved Mavyret (glecaprevir and pibrentasvir) to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 3, 2017 Category: Drugs & Pharmacology Source Type: news

FDA approves Mavyret for Hepatitis C
The U.S. Food and Drug Administration today approved Mavyret (glecaprevir and pibrentasvir) to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including patients with moderate to severe kidney disease and those who are on dialysis. Mavyret is also approved for adult patients with HCV genotype 1 infection who have been previously treated with a regimen either containing an NS5A inhibitor or an NS3/4A protease inhibitor but not both. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 3, 2017 Category: American Health Source Type: news

GI Bleeding in Cirrhosis Patients With CAD and Cardiac Stents GI Bleeding in Cirrhosis Patients With CAD and Cardiac Stents
Cirrhotic patients often have varices and coagulopathy. Is it safe to treat these patients with dual antiplatelet therapy after cardiac stenting?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 3, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Gore touts reduced portal hypertension, complications in Viatorr Tips trial
W.L. Gore & Associates today released preliminary data from a trial of its Viatorr Tips endoprosthesis with controlled expansion, touting reduced portal hypertension treatment complications when compared to the company’s legacy Tips device and bare metal stents. Data from the study was presented at The International Liver Congress 2017 in Amsterdam, the Flagstaff, Ariz.-based company said. Preliminary data from the trial, which has 21 patients currently and is still enrolling, also indicated a reduction in hospital admissions from cirrhosis-related complications, including refractory ascites and sepsis, when the ...
Source: Mass Device - August 1, 2017 Category: Medical Devices Authors: Fink Densford Tags: Blood Management Clinical Trials Stent Grafts Stents Vascular W.L. Gore & Associates Source Type: news

Liver disease and alcohol: How YOU could find out if you have symptomless disease
LIVER disease and cirrhosis - can increase the risk of cancer and can be caused by drinking too much alcohol. (Source: Daily Express - Health)
Source: Daily Express - Health - July 31, 2017 Category: Consumer Health News Source Type: news

Combo Tx Fares Well in HIV-Positive Patients with HCV (CME/CE)
(MedPage Today) -- Sustained response in all HIV-positive patients without cirrhosis (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 26, 2017 Category: Consumer Health News Source Type: news

FDA approves Vosevi for Hepatitis C
The U.S. Food and Drug Administration has approved Vosevi to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis. Vosevi is a fixed-dose, combination tablet containing two previously approved drugs - sofosbuvir and velpatasvir - and a new drug, voxilaprevir. (Source: World Pharma News)
Source: World Pharma News - July 19, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

FDA Approves Vosevi (sofosbuvir, velpatasvir and voxilaprevir) for Hepatitis C
July 18, 2017 -- The U.S. Food and Drug Administration today approved Vosevi to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis. Vosevi is a fixed-dose, combination tablet... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 18, 2017 Category: Drugs & Pharmacology Source Type: news

FDA approves Vosevi for Hepatitis C
The U.S. Food and Drug Administration today approved Vosevi to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis. (Source: Food and Drug Administration)
Source: Food and Drug Administration - July 18, 2017 Category: American Health Source Type: news

Liver damage and alcohol: How do you know if you have symptomless cirrhosis?
CIRRHOSIS - is long-term liver damage that can eventually lead to liver failure and even increase the risk of cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - July 12, 2017 Category: Consumer Health News Source Type: news

The Link Between Cirrhosis and Stroke: New Findings The Link Between Cirrhosis and Stroke: New Findings
Stroke incidence in patients with cirrhosis was double that of those without cirrhosis. Several factors probably explain why.Medscape Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 12, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery Viewpoint Source Type: news

DAAs for Chronic HCV in a Population Aged 65 Years and Older DAAs for Chronic HCV in a Population Aged 65 Years and Older
Are direct-acting antivirals safe and effective in elderly patients with HCV-related advanced fibrosis or cirrhosis?Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 12, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news