Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis.
CONCLUSION: CNI salvage therapy is well tolerated and moderately effective achieving remission in around 50% of AIH who failed standard therapy. PMID: 33070650 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 20, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Alcoholic-related liver disease: pathogenesis, management and future therapeutic developments.
Authors: Argemi J, Ventura-Cots M, Rachakonda V, Bataller R Abstract Alcohol-related liver disease (ALD) is the most frequent cause of advanced chronic liver disease worldwide. Excessive and prolonged alcohol use leads to ALD, which ranges from early forms such as alcoholic fatty liver (AFL) and alcoholic steatohepatitis (ASH), through progressive fibrosis to cirrhosis and the development of hepatocellular cancer (HCC). In addition, patients with underlying ALD and continuous alcohol use can develop alcoholic hepatitis (AH), which presents a rapid progression of liver failure and has a high short-term mortality. Ge...
Source: Revista Espanola de Enfermedades Digestivas - October 20, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Quality of care provided to outpatients with hepatic cirrhosis in a teaching hospital.
CONCLUSIONS: despite excellent results for some quality indicators, most required improvement, especially vaccinations. The quality of care achieved by residents is equal to and even better than that of experienced physicians. Measuring quality of care is essential to analyze and improve the health care of cirrhotic outpatients and may be a useful tool for supervising specialists in training. PMID: 33054285 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - October 20, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Alcohol and hepatocarcinogenesis.
Authors: Taniai M Abstract An excessive alcohol intake may result in fatty liver, acute/chronic hepatitis, cirrhosis, and lead to hepatocellular carcinoma (HCC). The aim of this review is to clarify the present condition and the mechanisms of alcohol-related hepatocarcinogenesis and clinical risk factors for alcohol-related HCC. There are several possible mechanisms through which alcohol may induce hepatocarcinogenesis, including the mutagenic effects of acetaldehyde toxicity through the formation of protein and DNA adducts and the production of reactive oxygen species due to the excessive hepatic deposition of iro...
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Roles of the complement system in alcohol-induced liver disease.
Authors: Zhou Y, Yuan G, Zhong F, He S Abstract Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and currently no effective drugs are available for ALD, several lines of evidence suggest that complement activation and oxidative stress play crucial roles in the pathogenesis of ALD. Complement activation can regulate the production of ROS and influence oxidative stress in ALD. Precise regulation of the complement system in ALD may be a ration...
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC).
Authors: Kim DJ, Jeong WI, Tsukamoto H, Gao B PMID: 33053933 [PubMed - in process] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Clinical outcomes of coronavirus disease 2019 in patients with pre-existing liver diseases: A multicenter study in South Korea.
Authors: Lee YR, Kang MK, Song JE, Kim HJ, Kweon YO, Tak WY, Jang SY, Park JG, Lee C, Hwang JS, Jang BK, Suh JI, Chung WJ, Kim BS, Park SY Abstract BACKGROUND/AIMS: Although coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, the implication of pre-existing liver disease on the outcome of COVID-19 remains unresolved. . METHODS: A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19 were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and morta...
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Sarcopenia and blood myokine levels as prognostic biomarkers in patients with liver cirrhosis or hepatocellular carcinoma.
Authors: Oh S, Lee J PMID: 33053929 [PubMed - in process] (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Managing liver cirrhotic complications: Overview of esophageal and gastric varices.
Authors: Lesmana CRA, Raharjo M, Gani RA Abstract Managing liver cirrhosis in clinical practice is still a challenging problem as its progression is associated with serious complications, such as variceal bleeding that may increase mortality. Portal hypertension (PH) is the main key for the development of liver cirrhosis complications. Portal pressure above 10 mmHg, termed as clinically significant portal hypertension, is associated with formation of varices; meanwhile, portal pressure above 12 mmHg is associated with variceal bleeding. Hepatic vein pressure gradient measurement and esophagogastroduodenoscopy remai...
Source: Clinical and molecular hepatology - October 20, 2020 Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research

Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update.
Authors: Fukui H Abstract Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of microbial products. In so-called "leaky gut," the increased intestinal permeability for bacteria and their products constitutes an important pathogenetic factor for major complications in patients with liver cirrhosis. Prolonged gastric and small intestinal transit may induce intestinal bacterial overgrowth, a condition in which colonic bacteria translocate into the small gut. Cirrhotic patients furthe...
Source: Gut and Liver - October 20, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

Successfully Treated Case of Cholangiolocellular Carcinoma with a Poor Hepatic Functional Reserve Reporting with Various Imaging Findings.
Authors: Takakusagi S, Yokoyama Y, Kizawa K, Marubashi K, Kosone T, Sato K, Kakizaki S, Harada K, Takagi H, Uraoka T Abstract Cholangiolocellular carcinoma (CoCC) is a rare primary liver cancer that is difficult diagnose due to a lack of specific imaging findings. We herein report a case of CoCC accompanied by severe alcoholic cirrhosis. Dynamic computed tomography showed a low-density tumor with a faint surrounding enhancement. Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging revealed iso-intensity in the hepatobiliary phase and a maximum tumor diameter of 53 mm. 18F-...
Source: Internal Medicine - October 20, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

The clinical efficacy and adverse effects of Entecavir plus Thymosin alpha-1 combination therapy versus Entecavir Monotherapy in HBV-related cirrhosis: a systematic review and meta-analysis
Previous studies have demonstrated the benefits of thymosin alpha-1 (T α1) in anti-virus, immunological enhancement and anti-inflammation. However, it is controversial about the efficacy and safety of entecavir... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 19, 2020 Category: Gastroenterology Authors: Dan Peng, Hai-Yan Xing, Chen Li, Xian-Feng Wang, Min Hou, Bin Li and Jian-Hong Chen Tags: Research article Source Type: research

Non-invasive assessment of liver fibrosis in autoimmune hepatitis: Diagnostic value of liver magnetic resonance parametric mapping including extracellular volume fraction
AbstractPurposeAutoimmune hepatitis (AIH) is an immune-mediated chronic liver disease that leads to severe fibrosis and cirrhosis. The aim of this study was to determine the diagnostic value of T1 and T2 mapping as well as extracellular volume fraction (ECV) for non-invasive assessment of liver fibrosis in AIH patients.MethodsIn this prospective study, 27 patients (age range: 19 –77 years) with AIH underwent liver MRI. T1 and T2 relaxation times as well as ECV were quantified by mapping techniques. The presence of significant fibrosis (≥ F2) was defined as magnetic resonance elastography (MRE)-based li...
Source: Abdominal Imaging - October 19, 2020 Category: Radiology Source Type: research

Resveratrol increases the activation markers and changes the release of inflammatory cytokines of hepatic stellate cells.
Abstract The phytoalexin Resveratrol (3,5,4'-trihydroxystilbene; RSV) has been related to numerous beneficial effects on health by its cytoprotection and chemoprevention activities. Liver fibrosis is characterized by the extracellular matrix accumulation after hepatic injury and can lead to cirrhosis. Hepatic stellate cells (HSC) play a crucial role during fibrogenesis and liver wound healing by changing their quiescent phenotype to an activated phenotype for protecting healthy areas from damaged areas. Strategies on promoting the activated HSC death, the quiescence return or the cellular activation stimuli decrea...
Source: Molecular and Cellular Biochemistry - October 19, 2020 Category: Biochemistry Authors: de Oliveira CM, Martins LAM, de Sousa AC, Moraes KDS, Costa BP, Vieira MQ, Coelho BP, Borojevic R, de Oliveira JR, Guma FCR Tags: Mol Cell Biochem Source Type: research

Cancers, Vol. 12, Pages 3025: Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Status and Novel Perspectives
olino Bruno Daniele Immune checkpoint inhibitors (ICIs) represent a promising treatment for many kinds of cancers, including hepatocellular carcinoma (HCC). The rationale for using ICIs in HCC is based on the immunogenic background of hepatitis and cirrhosis and on the observation of high programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes in this cancer. Promising data from phase I/II studies in advanced HCC, showing durable objective response rates (~20% in first- and second-line settings) and good safety profile, have led to phase III studies with ICIs as single agents or...
Source: Cancers - October 18, 2020 Category: Cancer & Oncology Authors: Piera Federico Angelica Petrillo Pasqualina Giordano Davide Bosso Antonietta Fabbrocini Margaret Ottaviano Mario Rosanova Antonia Silvestri Andrea Tufo Antonio Cozzolino Bruno Daniele Tags: Review Source Type: research

Recurrent Pyroglutamic Acidosis in the context of Undiagnosed Liver Cirrhosis – A Case Report
Publication date: Available online 17 October 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Bradley J.W. Allen, Ahmed A. Abu Shanab, Mark R. Anderson, Edward Fogden (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 17, 2020 Category: Gastroenterology Source Type: research

Transplants for Acute Alcoholic Hepatitis
Liver transplant for severe alcohol-associated hepatitis remains a controversial practice despite evidence for a substantial survival benefit compared with medical therapy and posttransplant alcohol relapse rates comparable with previously published studies in alcohol-associated cirrhosis. The controversy stems in part from concern regarding patient selection practices, lack of long-term follow-up data, and the potential negative public perception of the practice affecting organ donation. Despite these concerns, it seems that early liver transplant for alcohol-associated hepatitis is increasingly being offered to selected ...
Source: Clinics in Liver Disease - October 17, 2020 Category: Gastroenterology Authors: Jessica Hause, John P. Rice Source Type: research

The impact of bariatric surgery on in-patient clinical outcomes among patients with autoimmune hepatitis
Autoimmune hepatitis (AIH) is a form of liver inflammation in which immune cells target hepatocytes, inducing chronic inflammatory states. Bariatric surgery (BS) was shown to reduce inflammation in severely obese patients. We hypothesize that obese patients with AIH and BS have lower prevalence of liver-related complications and in-patient mortality compared to those without BS. The National Inpatient Sample from 2007 to 2013 was queried for hospitalizations of adults over 18 years of age with a diagnosis of AIH. Of those, hospitalizations with BS were selected as cases and those with morbid obesity as controls. Case-cont...
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Conversion therapy for unresectable hepatocellular carcinoma after lenvatinib: Three case reports
This study demonstrated that LEN enables downstaging of HCC and thus represents a bridge to successful surgery or ablation therapy. In particular, LEN treatment may facilitate the possibility for conversion therapy of initially unresectable HCC, while maintaining the hepatic functional reserve. (Source: Medicine)
Source: Medicine - October 16, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality
Lay summary: Patients with advanced chronic liver disease (ACLD; i.e. liver cirrhosis) have a certain risk of mortality according to their stage of disease. Progression of disease is greatly influenced by increased pressure in the portal venous system (i.e. portal hypertension) and occurrence of clinical complications (i.e. decompensation). Our study demonstrates that systemic inflammation markedly increases across highest disease stages, and the inflammation biomarker interleukin-6 in blood may specifically indicate risk of disease progression in patients with ACLD. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 16, 2020 Category: Gastroenterology Authors: Dalila COSTA, Benedikt SIMBRUNNER, Mathias JACHS, Lukas HARTL, David BAUER, Rafael PATERNOSTRO, Philipp SCHWABL, Bernhard SCHEINER, Albert Friedrich ST ÄTTERMAYER, Matthias PINTER, Michael TRAUNER, Mattias MANDORFER, Thomas REIBERGER Source Type: research

Eating quickly is associated with a low aspartate aminotransferase to alanine aminotransferase ratio in middle-aged adults: a large-scale cross-sectional survey in Japan
This study sought to investigate the relationship between eating quickly and an elevated ALT or a low AST/ALT ratio in Japanese middle-aged adults.MethodsThe present study included 283,073 adults aged 40 –64 years who had annual health checkups in Japan from April 2013 to March 2014. The data of serum parameters and lifestyle factors, including eating speed, were analyzed. An elevated ALT was defined as>  40 U/L, and a low AST/ALT ratio was defined as
Source: Archives of Public Health - October 16, 2020 Category: International Medicine & Public Health Source Type: research

Evaluation of 3D PLLA scaffolds coated with nano ‐thick collagen as carrier for hepatocytes
In this study, we investigated 3D porous scaffolds made of PLLA coated with a nano thick c ollagen layer (matrices). Primary rat dermal fibroblasts were used in a first study phase to check matrices' cytocompatibility. More than 70% of seeded cells could adhere and remain viable 24 and 48 hours after the seeding. To test the suitability of the matrices for human primary hepatocytes, Hep aRG cells were seeded and analyzed for viability, adhesion rate, and functionality such as albumin secretion. About 80% of seeded HepaRG adhered to the scaffolds remaining viable up to 72 hours. Cells were homogeneously distri...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 16, 2020 Category: Materials Science Authors: Siufui Hendrawan, Epifania Bono, Albert Hutter, Ursula Weber, Jennifer Lheman, Hans U. Baer Tags: ORIGINAL RESEARCH REPORT Source Type: research

Using Child ‐Pugh Class to Optimize Voriconazole Dosage Regimens and Improve Safety in Patients with Liver Cirrhosis: Insights from a Population Pharmacokinetic Model‐based Analysis
AbstractBackgroundCirrhotic patients are at a high risk of fungal infections. Voriconazole is widely used as prophylaxis and in the treatment of invasive fungal disease. However, the safety, pharmacokinetics and optimal regimens of voriconazole are currently not well defined in cirrhotic patients.DesignRetrospective pharmacokinetics studySettingTwo large, academic, tertiary ‐care medical center.PatientsTwo hundred and nineteen plasma trough concentrations (Cmin) from 120 cirrhotic patients and 83 plasma concentrations from 11 non ‐cirrhotic patients were included.MethodsData pertaining to voriconazole were collected re...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 16, 2020 Category: Drugs & Pharmacology Authors: Taotao Wang, Miao Yan, Dan Tang, Yuzhu Dong, Li Zhu, Qian Du, Dan Sun, Jianfeng Xing, Yalin Dong Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Management and outcomes of Burkholderia cepacia complex bacteremia in patients without cystic fibrosis: a retrospective observational study
The objective was to evaluate the management and outcomes of BCC bacteremia in patients without CF. We conducted a retrospective study of non-CF adult patients with BCC bacteremia between January 1997 and December 2016 at 4 tertiary hospitals in South Korea. A total of 216 non-CF patients with BCC bacteremia were identified. Most cases were hospital-acquired (79.2%), and the most common source was a central venous catheter (CVC) (42.1%). The rates of susceptibility to trimethoprim-sulfamethoxazole and piperacillin-tazobactam of BCC isolates were high as 92.8% and 90.3%, respectively. The rates of susceptibility to ceftazid...
Source: European Journal of Clinical Microbiology and Infectious Diseases - October 15, 2020 Category: Microbiology Source Type: research

Spontaneous Regression of Advanced Hepatocellular Carcinoma
In this report, we discuss possible mechanisms of spontaneous tumor regression and its therapeutic implications.Case Rep Gastroenterol 2020;14:491 –496 (Source: Case Reports in Gastroenterology)
Source: Case Reports in Gastroenterology - October 15, 2020 Category: Gastroenterology Source Type: research

Statins in liver cirrhosis in a developing country: benefits overweigh the risk?
Authors: Gonzáles Yovera JG, Concepción-Zavaleta MJ, Moreno Marreros DM, Armas Flórez CD PMID: 33047634 [PubMed - as supplied by publisher] (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - October 15, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial
Hepatic encephalopathy (HE) is associated with increased morbidity, mortality, and healthcare resource use. In this phase 2b study, we evaluated the efficacy and safety of ornithine phenylacetate (OP), an ammonia scavenger, in hospitalized patients with cirrhosis, increased levels of ammonia at screening, and acute or overt HE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 15, 2020 Category: Gastroenterology Authors: Robert S. Rahimi, Rifaat Safadi, Dominique Thabut, Kalyan Ram Bhamidimarri, Nikolaos Pyrsopoulos, Amy Potthoff, Stan Bukofzer, Jasmohan S. Bajaj Source Type: research

Expert Panel Review on Non-Alcoholic Fatty Liver Disease in Persons with HIV
Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults in the general population and is a disease spectrum ranging from steatosis to non-alcoholic steatohepatitis (NASH) to end-stage liver disease. NAFLD is an independent risk factor for cardiovascular disease, diabetes mellitus and all-cause mortality, and NASH cirrhosis is a frequent indication for liver transplantation. In persons with HIV (PWH), chronic liver disease is the second leading cause of non-HIV-related mortality. Between 20-63% of PWH have NASH, and 14-63% have NASH with fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 15, 2020 Category: Gastroenterology Authors: Jordan E. Lake, Turner Overton, Susanna Naggie, Mark Sulkowski, Rohit Loomba, David E. Kleiner, Jennifer C. Price, Kara W. Chew, Raymond T. Chung, Kathleen E. Corey Source Type: research

Phase Angle Is an Independent Predictor of 6-Month Mortality in Patients With Decompensated Cirrhosis: A Prospective Cohort Study.
CONCLUSIONS: The PA is an independent predictor of 6-month mortality in patients with decompensated cirrhosis. Therefore, PA may be useful to assess the nutrition status and identify patients at the highest risk of mortality in clinical practice. PMID: 33058222 [PubMed - as supplied by publisher] (Source: Nutrition in Clinical Practice)
Source: Nutrition in Clinical Practice - October 15, 2020 Category: Nutrition Authors: Saueressig C, Glasenapp JH, Luft VC, Alves FD, Ferreira PK, Hammes TO, Dall'Alba V Tags: Nutr Clin Pract Source Type: research

Stratification of Major Hepatectomies According to Their Outcome: Analysis of 2212 Consecutive Open Resections in Patients Without Cirrhosis
Conclusions: The term “major hepatectomy” includes resections having heterogeneous outcome. Different MajHs can be stratified according to their mortality, severe morbidity, liver failure, and bile leak rates. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

The Impact of Hospital Volume on Failure to Rescue after Liver Resection for Hepatocellular Carcinoma: Analysis from the HE.RC.O.LE.S. Italian Registry
Conclusions: Risk of major complications and mortality was related with comorbidities, cirrhosis severity, and complexity of surgery. These factors were not correlated with FTR. Center's volume was the only independent predictor related with severe complications, mortality, and FTR. (Source: Annals of Surgery)
Source: Annals of Surgery - October 14, 2020 Category: Surgery Tags: PAPERS CHOSEN FOR PRESENTATION AT THE 2020 ANNUAL MEETING OF THE EUROPEAN SURGICAL ASSOCIATION Source Type: research

The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis
ConclusionsOur data indicate that susceptibility to non-traumatic fractures in ALC patients could be explained by alterations in trabecular bone micro-architecture. Thus, we genuinely recommend osteological screening of the lumbar spine for all ALC patients in order to evaluate individual fracture risk.Graphical abstract (Source: Osteoporosis International)
Source: Osteoporosis International - October 14, 2020 Category: Orthopaedics Source Type: research

Prognostic Value of Hypochloremia in Critically Ill Patients With Decompensated Cirrhosis
This study aimed to investigate the prognostic value of serum chloride and its association with mortality in cirrhotic patients. Design: Retrospective cohort study. Setting: The medical ICU at Parkland Memorial Hospital, a tertiary care public health system in Dallas, Texas. Patients: Adult patients with confirmed diagnosis of decompensated cirrhosis who were admitted to the ICU between March 2015 and March 2017. Interventions: None. Measurements and Main Results: Kaplan-Meier analysis and multivariable Cox proportional hazard ratio models were performed to determine the impact of hypochloremia on 180-day mo...
Source: Critical Care Medicine - October 14, 2020 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Serum AFU, GGT and TK1 levels in PHC patients and their correlation with clinicopathology and diagnostic value.
Authors: Gong G, Zheng K, Xue S, Hou J, Zhang Q Abstract To investigate the expression level and clinical significance of fucosidase (AFU), glutamyltranspeptidase (GGT), and thymidine kinase 1 (TK1) in the serum of patients with primary liver cancer (PHC). A total of 135 PHC patients in Baoji Central Hospital from September 2014 to February 2018 were selected as a research group (RG), while 127 healthy subjects were collected as a control group (CG). Enzyme-linked immunosorbent assay (ELISA) was used to detect the AFU, GGT, and TK1 concentrations in serum of the two groups, and the diagnostic value of combined dete...
Source: Cellular and Molecular Biology - October 14, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Ascites management by cell-free concentrated ascites reinfusion therapy during recovery from drug-induced acute liver injury: a case report
AbstractBackgroundThe symptoms of drug-induced hepatic injury are manifold; however, the presence of ascites indicates a severe disease condition. The rapid accumulation of ascites is distressing and requires palliative treatment. Because many cases are addressed by repeated large-volume paracentesis, often resulting in impairment due to protein and electrolyte loss, a different approach is required.Case presentationA 61-year-old Japanese man on maintenance dialysis was admitted to our hospital with acute liver injury. Our patient was diagnosed as having drug-induced liver injury due to warfarin or diltiazem, which started...
Source: Journal of Medical Case Reports - October 14, 2020 Category: General Medicine Source Type: research

The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer
Primary liver cancer is one of the leading causes of cancer death worldwide. Surgical and non-surgical treatments are optional for liver cancer therapy based on the cancer stage. Accumulating studies show that the gut–liver axis influences the progression of liver diseases, including liver inflammation, fibrosis, cirrhosis, and cancer. However, the role of gut microbiota and their derived components and metabolites in liver cancer remains to be further clarified. In this review, we discuss the roles of gut microbiota and specific bacterial species in HCC and the strategies to modulate gut microbiota to improve antitu...
Source: Frontiers in Oncology - October 14, 2020 Category: Cancer & Oncology Source Type: research

Agreement between wedged hepatic venous pressure and portal pressure in non-alcoholic steatohepatitis-related cirrhosis.
Wedge hepatic vein pressure (WHVP) accurately estimates portal pressure (PP) in alcohol or viral hepatitis-related cirrhosis. Whether this also holds true in cirrhosis due to non-alcoholic steatohepatitis (NASH) is unknown. We aimed to evaluate the agreement between WHVP and PP in patients with NASH cirrhosis in comparison with patients with alcohol or hepatitis C virus (HCV)-related cirrhosis. (Source: Journal of Hepatology)
Source: Journal of Hepatology - October 14, 2020 Category: Gastroenterology Authors: Jos é Ferrusquía-Acosta, Octavi Bassegoda, Laura Turco, Enric Reverter, Monica Pellone, Marcello Bianchini, Valeria Campuzano, Enric Ripoll, Ángeles García-Criado, Isabel Graupera, Juan Carlos García-Pagán, Filippo Schepis, Marco Senzolo, Virginia H Source Type: research

Lights Off, Camera On! Laparoscopic Cholecystectomy Improves Outcomes in Cirrhotic Patients with Acute Cholecystitis
This study aimed to evaluate treatment options in cirrhotic patients with AC. We hypothesized that Laparoscopic Cholecystectomy (LC) would lead to better clinical outcomes when compared to Non ‐operative management (NOM) and open cholecystectomy (OC), independent of the severity of liver cirrhosis.MethodsPatients from the National Inpatient Sample diagnosed with AC were stratified into no cirrhosis (NC), compensated cirrhosis (CC), and decompensated cirrhosis (DC) and analyzed according to treatment: NOM, OC and LC. Primary outcome was in ‐hospital mortality. Secondary outcomes included hospital length of stay (HLOS), ...
Source: Journal of Hepato-Biliary-Pancreatic Sciences - October 14, 2020 Category: Gastroenterology Authors: Tiago Finco, Matthew Firek, Bruno C. Coimbra, Megan Brenner, Raul Coimbra Tags: ORIGINAL ARTICLE Source Type: research

pCLIF-SOFA is a reliable outcome prognostication score of critically ill children with cirrhosis: an ESPNIC multicentre study
Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - October 14, 2020 Category: Intensive Care Authors: Caroline Claude, Akash Deep, Martin Kneyber, Salman Siddiqui, Sylvain Renolleau, Luc Morin, Emmanuel Jacquemin, Jean-Paul Teglas, Vincent Gajdos, Pierre Tissi ères and Philippe Durand Tags: Research Source Type: research

Increased Mortality Risk in Autoimmune Hepatitis: A Nationwide Population-based Cohort Study With Histopathology
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that may lead to cirrhosis and liver failure, but data on overall mortality in AIH are conflicting. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 13, 2020 Category: Gastroenterology Authors: Rajani Sharma, Elizabeth C. Verna, Jonas S öderling, Bjorn Roelstraete, Hannes Hagström, Prof Jonas F Ludvigsson Source Type: research

Spleen and Liver Stiffness for Predicting High-Risk Varices in Patients with Compensated Liver Cirrhosis
The study evaluates the utility of spleen (SS) and liver stiffness (LS) associated with spleen size (SSZ) as non-invasive markers for predicting high-risk varices (HRV). One hundred thirty-two patients with compensated liver cirrhosis who underwent abdominal ultrasound SS (SSM) and LS measurements (LSM) using a 2-D shear wave elastography (2-D-SWE) technique from General Electric and upper endoscopy were included. Similar rates of reliable SSM and LSM were obtained (95.4% and 97.7% respectively); therefore, 124 patients were included in the final analysis. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - October 13, 2020 Category: Radiology Authors: Renata Fofiu, Felix Bende, Alina Popescu, Roxana Şirli, Raluca Lupușoru, Ana-Maria Ghiuchici, Ioan Sporea Tags: Original Contribution Source Type: research

Anti-viral effect in chronic hepatitis B patients with normal or mildly elevated alanine aminotransferase.
Abstract BACKGROUND & AIMS: Normal/mildly elevated ALT (30-years. The rate of undetectable HBV DNA in NAs and PEG-IFN groups was ∼50%, ∼80% or ∼90% at week 24, 48 or 72, respectively. HBeAg clearance rate was lower in NAs treated than that in PEG-IFN group at week 48 (6% vs 20%, P
Source: Antiviral Research - October 13, 2020 Category: Virology Authors: Zhao Q, Liu K, Zhu X, Yan L, Ding Y, Xu Y, Lou S, Zhao G, Xie Q, Gao Y, Bao S, Wang H Tags: Antiviral Res Source Type: research

Seizure-induced thoracolumbar burst fracture secondary to cirrhosis: A case report
Publication date: March 2021Source: Interdisciplinary Neurosurgery, Volume 23Author(s): Dong-Ju Lim, Sang-Yeup Shim (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - October 12, 2020 Category: Neurosurgery Source Type: research

Circulating glucagon-like peptide-1 level in patients with liver cirrhosis
. (Source: Archives of Physiology and Biochemistry)
Source: Archives of Physiology and Biochemistry - October 12, 2020 Category: Physiology Authors: Masoud Nouri-Vaskeh Neda Khalili Amirreza Khalaji Pouya Behnam Leila Alizadeh Sara Ebrahimi Neda Gilani Mehdi Mohammadi Seyed Alisalar Madinehzadeh Mohammad Zarei Source Type: research

Obesity Management of Liver Transplant Waitlist Candidates and Recipients
Obesity is increasing in prevalence in liver transplant candidates and recipients. The rise in liver transplantation for nonalcoholic steatohepatitis reflects this increase. Management of obesity in liver transplant candidates can be challenging due to the presence of decompensated cirrhosis and sarcopenia. Obesity may increase peritransplant morbidity but does not have an impact on long-term post-transplant survival. Bariatric surgery may be a feasible option in select patients before, during, or after liver transplantation. Use of weight loss drugs and/or endoscopic therapies for obesity management ultimately may play a ...
Source: Clinics in Liver Disease - October 12, 2020 Category: Gastroenterology Authors: Danielle Brandman Source Type: research

Compensated Cirrhosis is Associated with Increased Risk of Complications following Total Hip Arthroplasty in a Large Medicare Database
The aim of this study was to evaluate medical and surgical complications of liver cirrhosis patients following THA, with attention to different etiologies of cirrhosis and their financial burden following THA. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - October 12, 2020 Category: Orthopaedics Authors: Sean B. Sequeira, Lawal A. Labaran, Joshua E. Bell, Raj M. Amin, Sandesh S. Rao, Brian C. Werner Source Type: research

Haemodynamic changes in cirrhosis following terlipressin and induction of sepsis —a preclinical study using caval subtraction phase-contrast and cardiac MRI
ConclusionsCaval subtraction PCMRI and cardiac MRI in a rodent model of cirrhosis demonstrate significant baseline hepatic haemodynamic/cardiac differences, failure of the HA buffer response post-terlipressin and an altered HA fraction response in sepsis, informing potential translation to ACLF patients.Key PointsCaval subtraction phase-contrast and cardiac MRI demonstrate:• Significant differences between cirrhotic/non-cirrhotic rodent hepatic blood flow and cardiac systolic function at baseline.• Failure of the hepatic arterial buffer response in cirrhotic rodents in response to terlipressin.• Reductions i...
Source: European Radiology - October 12, 2020 Category: Radiology Source Type: research

Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis.
Authors: Li M, Guo Z, Zhang D, Xu X, Romeiro FG, Mancuso A, Zhang J, Feng R, Zhou X, Hong C, Qi X Abstract Methods: Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), ...
Source: Gastroenterology Research and Practice - October 10, 2020 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

3D analysis of microvasculature in murine liver fibrosis models using synchrotron radiation-based microtomography
AbstractCirrhosis describes the development of excess fibrous tissue around regenerative nodules in response to chronic liver injury and usually leads to irreversible organ damage and end-stage liver disease. During the development of cirrhosis, the formation of collagenous scar tissue is paralleled by a reorganization and remodeling of the hepatic vascular system. To date, macrovascular remodeling in various cirrhosis models has been examined using three-dimensional (3D) imaging modalities, while microvascular changes have been studied mainly by two-dimensional (2D) light microscopic and electron microscopic imaging. Here...
Source: Angiogenesis - October 10, 2020 Category: Molecular Biology Source Type: research

Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics
ConclusionsThe study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection. (Source: International Journal of Public Health)
Source: International Journal of Public Health - October 10, 2020 Category: International Medicine & Public Health Source Type: research