Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2024 Category: Respiratory Medicine Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Unraveling the Heterogeneity of CD8+ T-Cell Subsets in Liver Cirrhosis: Implications for Disease Progression
CONCLUSIONS: : In summary, this comprehensive study defines specialized CD8+ T-cell subpopulations in cirrhosis, with CXCL13+ Tex cells displaying an exhausted phenotype associated with immune dysregulation and advanced disease. Key genes and pathways regulating these cells present potential therapeutic targets.PMID:38623058 | DOI:10.5009/gnl230345 (Source: Gut and Liver)
Source: Gut and Liver - April 16, 2024 Category: Gastroenterology Authors: Kepu Zheng Leiyang Dai Shengning Zhang Yingpeng Zhao Wang Li Yang Gao Yuanyi Mang Lingfeng Jiao Yu Tang Jianghua Ran Source Type: research
Global prevalence of MAFLD-related hepatocellular carcinoma: A systematic review and meta-analysis
CONCLUSION: MAFLD is common as a sole aetiology, but more so and as a co-factor in mixed-aetiology HCC, supporting the use of a positive diagnostic criteria.PMID:38623613 | DOI:10.3350/cmh.2024.0109 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 16, 2024 Category: Gastroenterology Authors: Harry Crane Guy D Eslick Cameron Gofton Anjiya Shaikh George Cholankeril Mark Cheah Jian-Hong Zhong Gianluca Svegliati-Baroni Alessandro Vitale Beom Kyung Kim Sang Hoon Ahn Mi Na Kim Simone Strasser Jacob George Source Type: research
Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research
Treatment of Cavernous Transformation of Portal Vein Caused by Hepatic Cystic Echinococcosis Using Ex Vivo Liver Resection and Autotransplantation
CONCLUSIONS Through this paper, we aim to detail the treatment process, showcasing the feasibility and advantages of ELRA. Additionally, we propose a novel approach for the treatment of this disease, while emphasizing the importance of radical resection surgery to prevent long-term complications.PMID:38622855 | DOI:10.12659/AOT.942358 (Source: Annals of Transplantation)
Source: Annals of Transplantation - April 16, 2024 Category: Transplant Surgery Authors: Ayidu Reyimu Jiang Tiemin Shao Yingmei Zhu Xuepeng Guo Wenjiang Du Yuhao Dilixiati Halimulati Wusiman Ababokeli Aji Tuerganaili Wen Hao Source Type: research
Cancers, Vol. 16, Pages 1513: Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Manasi Das Deepak Kumar Consuelo Sauceda Alexis Oberg Lesley G. Ellies Liping Zeng Lily J. Jih Isabel G. Newton Nicholas J. G. Webster Tags: Article Source Type: research
Viruses, Vol. 16, Pages 618: Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections
Nugent
Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015–2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cirrhosi...
Source: Viruses - April 16, 2024 Category: Virology Authors: Busara Songtanin Nattanicha Chaisrimaneepan Roberto Mend óza Kenneth Nugent Tags: Review Source Type: research
Liver cancer wars: plant-derived polyphenols strike back
AbstractLiver cancer currently represents the leading cause of cancer-related death worldwide. The majority of liver cancer arises in the context of chronic inflammation and cirrhosis. Surgery, radiation therapy, and chemotherapy have been the guideline-recommended treatment options for decades. Despite enormous advances in the field of liver cancer therapy, an effective cure is yet to be found. Plant-derived polyphenols constitute a large family of phytochemicals, with pleiotropic effects and little toxicity. They can drive cellular events and modify multiple signaling pathways which involves initiation, progression and m...
Source: Medical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1521: Hepatitis-C-Related Hepatocellular Carcinoma, Still a Relevant Etiology beyond a Hepatitis C Infection Cure
Conclusions: Whereas accessibility to antiviral therapy is granted, HCV infection remains as one of the main HCC etiologies. MASLD-related HCC, although growing globally, is not as relevant in our area. Strong public policies need to be implemented to prevent alcohol consumption, the main etiology of liver disease and liver cancer. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Elena Vargas-Accarino M ónica Higuera Mar ía Buti Beatriz M ínguez Tags: Article Source Type: research
Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
ConclusionsThe quantitative measurement system for M2BPGi depends on liver fibrosis and inflammation, regardless of etiology. Liver inflammation complicates the interpretation of M2BPGi-Qt results when assessing the fibrosis stage. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Source Type: research
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Por... (Source: Trials)
Source: Trials - April 16, 2024 Category: General Medicine Authors: Vishal C. Patel, Mark J. McPhail, Ruhama Uddin, Hassan Jafari, Vanessa Lawrence, Clair Le Boutillier, James Shearer, Nahel Yaziji, Angela Cape, Haroon Ahmed, Christopher Ward, Peter Walsh, Kevin Besly, Ane Zamalloa, Joanna Kelly and Ben Carter Tags: Study protocol Source Type: research
Construction of a nomogram for predicting compensated cirrhosis with Wilson ’s disease based on non-invasive indicators
Wilson ’s disease (WD) often leads to liver fibrosis and cirrhosis, and early diagnosis of WD cirrhosis is essential. Currently, there are few non-invasive prediction models for WD cirrhosis. The purpose of thi... (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - April 16, 2024 Category: Radiology Authors: Yan Li, Jing Ping Wang and Xiaoli Zhu Tags: Research Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
Underfunding of German university-based high-performance medicine exemplified by the treatment of varices in cirrhosis
This study examines whether university-based high-performance medicine is efficient and cost-covering within the framework of the G-DRG system. We demonstrate a dramatic underfunding of the management of varicose veins in cirrhosis in our university center. It is therefore generally questionable whether and to what extent an adequate care for this patient collective is reflected in the G-DRG system.PMID:38616470 | DOI:10.1016/j.zefq.2024.03.003 (Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen)
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - April 15, 2024 Category: Health Management Authors: Simone Claus Jonathan F Brozat Christian Trautwein Alexander Koch Source Type: research
Effects of < em > Lactobacillus paracasei < /em > N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis
CONCLUSION: LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota, improving liver function, and reducing inflammatory factor levels.PMID:38617455 | PMC:PMC11008409 | DOI:10.3748/wjg.v30.i11.1556 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Source Type: research
