Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.
Abstract OBJECTIVE: A minipig model was employed to explore the changes in endogenous leptin transport into the central nervous system and in hypothalamic sensitivity to exogenous leptin when individuals are placed on high-fat diet (HFD) compared with standard diet. METHODS: Serum and cerebrospinal fluid (CSF) leptin concentrations during 10 weeks of HFD versus standard diet and exogenous leptin-induced STAT3 phosphorylation in the hypothalamus of minipigs were assessed, and the hypothalamic leptin-sensitive cells were characterized by immunofluorescence. RESULTS: The efficiency of the passage of endogen...
Source: Obesity - April 21, 2019 Category: Eating Disorders & Weight Management Authors: Chmielewski A, Hubert T, Descamps A, Mazur D, Daoudi M, Ciofi P, Fontaine C, Caiazzo R, Pattou F, Prevot V, Pigeyre M Tags: Obesity (Silver Spring) Source Type: research

The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18 F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults.
CONCLUSIONS: BAT volume and metabolic activity play a role in the relationship between Personal-ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat. PMID: 31006988 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 21, 2019 Category: Eating Disorders & Weight Management Authors: Martinez-Tellez B, Adelantado-Renau M, Acosta FM, Sanchez-Delgado G, Martinez-Nicolas A, Boon MR, Llamas-Elvira JM, Martinez-Vizcaino V, Ruiz JR Tags: Obesity (Silver Spring) Source Type: research

Physiological Predictors of Weight Regain at 1-Year Follow-Up in Weight-Reduced Adults with Obesity.
This study aimed to assess whether changes in resting metabolic rate (RMR), exercise-induced energy expenditure (EIEE), and appetite following weight loss (WL) are associated with weight regain at 1 year. METHODS: Thirty-six adults with obesity underwent 8 weeks of a very-low-energy diet, followed by 4 weeks of refeeding and a 1-year maintenance program. RMR, EIEE, appetite ratings, and active ghrelin, peptide YY, glucagon-like peptide-1, cholecystokinin, and insulin concentrations were measured at baseline, week 13, and 1 year. RESULTS: A 17% WL (-20 ± 5 kg [mean ± SD]; ...
Source: Obesity - April 20, 2019 Category: Eating Disorders & Weight Management Authors: Nymo S, Coutinho SR, Rehfeld JF, Truby H, Kulseng B, Martins C Tags: Obesity (Silver Spring) Source Type: research

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.
CONCLUSIONS: Leptin partly (> 60%) mediated the association between high body adiposity and persistent asthma over time. Using a newly developed analytic approach, this longitudinal study brought new insight into one mechanism by which obesity may affect asthma activity. PMID: 31004416 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 20, 2019 Category: Eating Disorders & Weight Management Authors: Li Z, Leynaert B, Dumas O, Diaz Gil O, Garcia-Aymerich J, Fito Colomer M, Le Moual N, Pison C, Romieu I, Siroux V, Camargo CA, Varraso R, Nadif R Tags: Obesity (Silver Spring) Source Type: research

Metabolic Risk Factors Associated with Visceral and Subcutaneous Adipose Tissue in a Sex-Specific Manner in Seven-Year-Olds.
This study aimed to investigate how visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes were associated with metabolic risk factors in 7-year-old children. METHODS: A total of 81 children (52% girls) from a Swedish birth cohort were studied. At 6 years of age, anthropometric data, fasting insulin, glucose, cholesterol, and blood pressure were collected on 53 children with normal weight and 28 children with overweight or obesity, and insulin resistance was estimated. At 7 years of age, magnetic resonance imaging quantified VAT and SAT. Sex and regression analyses were conducted. R...
Source: Obesity - April 19, 2019 Category: Eating Disorders & Weight Management Authors: Kjellberg E, Roswall J, Andersson J, Bergman S, Karlsson AK, Svensson PA, Kullberg J, Dahlgren J Tags: Obesity (Silver Spring) Source Type: research

Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans.
CONCLUSIONS: It was concluded that increased CTGF expression is associated with adipose tissue expansion, adipose tissue fibrosis, and multi-organ insulin resistance in people with obesity. PMID: 31004409 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 19, 2019 Category: Eating Disorders & Weight Management Authors: Yoshino J, Patterson BW, Klein S Tags: Obesity (Silver Spring) Source Type: research

Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.
CONCLUSIONS: While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated. PMID: 31002478 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 19, 2019 Category: Eating Disorders & Weight Management Authors: Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LK Tags: Obesity (Silver Spring) Source Type: research

Individual Differences in Behavioral Responses to Palatable Food or to Cholecystokinin Predict Subsequent Diet-Induced Obesity.
CONCLUSIONS: Together, these data identify individual differences in behavioral responses to palatable food and to CCK as novel predictors of diet-induced obesity. PMID: 30998842 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 18, 2019 Category: Eating Disorders & Weight Management Authors: Wald HS, Grill HJ Tags: Obesity (Silver Spring) Source Type: research

Abdominal Fat in Individuals with Overweight Reduced by Consumption of a 1975 Japanese Diet: A Randomized Controlled Trial.
CONCLUSIONS: The intake of a diet with the characteristics of the 1975 JD may have beneficial effects on lipid metabolism in people with overweight and reduce the onset risk of metabolism-related disorders, such as obesity and diabetes. PMID: 30985996 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 15, 2019 Category: Eating Disorders & Weight Management Authors: Asano M, Kushida M, Yamamoto K, Tomata Y, Tsuji I, Tsuduki T Tags: Obesity (Silver Spring) Source Type: research

Glycated Hemoglobin, but not Insulin Sensitivity, is Associated with Memory in Subjects with Obesity.
CONCLUSIONS: Impairments in memory function in middle-aged women with obesity are associated with HbA1c levels and brain iron content independently of insulin sensitivity. These results may have implications in the design of therapeutic strategies in women with obesity. PMID: 30985999 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 15, 2019 Category: Eating Disorders & Weight Management Authors: Arnoriaga Rodríguez M, Blasco G, Coll C, Biarnés C, Contreras-Rodríguez O, Garre-Olmo J, Puig J, Gich J, Ricart W, Ramió-Torrentà L, Fernández-Real JM Tags: Obesity (Silver Spring) Source Type: research

Ripple Effect of Lifestyle Interventions During Pregnancy on Untreated Partners' Weight.
CONCLUSIONS: There was no evidence of a ripple effect on partner weight. In a self-selected sample, partners of pregnant women appeared not to experience sympathy weight gain. PMID: 30957985 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 8, 2019 Category: Eating Disorders & Weight Management Authors: Hagobian TA, Phelan S, Schaffner A, Brannen A, McHugh A, Ashby-Thompson M, Gorin AA, Pi-Sunyer X, Gallagher D, Wing R Tags: Obesity (Silver Spring) Source Type: research

Testing Bidirectional Associations Between Childhood Aggression and BMI: Results from Three Cohorts.
CONCLUSIONS: More aggressive behavior was prospectively associated with higher BMI and fat mass. This suggests that aggression contributes to the obesity problem, and future research should study whether these behavioral pathways to childhood obesity are modifiable. PMID: 30957987 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 8, 2019 Category: Eating Disorders & Weight Management Authors: Derks IPM, Bolhuis K, Yalcin Z, Gaillard R, Hillegers MHJ, Larsson H, Lundström S, Lichtenstein P, van Beijsterveldt CEM, Bartels M, Boomsma DI, Tiemeier H, Jansen PW Tags: Obesity (Silver Spring) Source Type: research

Response to "The Relationship between Youth Subjective Social Status and Weight Loss".
Response to "The Relationship between Youth Subjective Social Status and Weight Loss". Obesity (Silver Spring). 2019 Apr 05;: Authors: Cardel MI, Tong S, Pavela G, Dhurandhar E, Miller D, Boles R, Haemer M PMID: 30950577 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 5, 2019 Category: Eating Disorders & Weight Management Authors: Cardel MI, Tong S, Pavela G, Dhurandhar E, Miller D, Boles R, Haemer M Tags: Obesity (Silver Spring) Source Type: research

Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.
CONCLUSIONS: Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI. PMID: 30950584 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 5, 2019 Category: Eating Disorders & Weight Management Authors: Silventoinen K, Jelenkovic A, Latvala A, Yokoyama Y, Sund R, Sugawara M, Tanaka M, Matsumoto S, Aaltonen S, Piirtola M, Freitas DL, Maia JA, Öncel SY, Aliev F, Ji F, Ning F, Pang Z, Rebato E, Saudino KJ, Cutler TL, Hopper JL, Ullemar V, Almqvist C, Magnu Tags: Obesity (Silver Spring) Source Type: research

Do Calorimetric Results in Mice Depend on the System Being Used?
PMID: 30950585 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 5, 2019 Category: Eating Disorders & Weight Management Authors: Kaiyala KJ Tags: Obesity (Silver Spring) Source Type: research

The Relationship Between Youth Subjective Social Status (SSS) and Weight Loss.
PMID: 30942531 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 3, 2019 Category: Eating Disorders & Weight Management Authors: Moon RC Tags: Obesity (Silver Spring) Source Type: research

Comparison of Abdominal Obesity and Fatty Liver and Their Association with Insulin Resistance and Metabolic Syndrome in Chinese Adults.
CONCLUSIONS: There are significant differences between sexes regarding the association between NAFLD and abdominal obesity status and MetS components. PMID: 30942551 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 3, 2019 Category: Eating Disorders & Weight Management Authors: Jiang B, Chen Y, Zhou K, Zheng Y, Chen Y, Li Q, Zhu C, Xia F, Gu T, Guo Y, Lu Y Tags: Obesity (Silver Spring) Source Type: research

Blatant Dehumanization of People with Obesity.
CONCLUSIONS: This study provides the first evidence that people with obesity are blatantly dehumanized. This tendency to consider people with obesity as less human reveals the level of obesity stigma and may facilitate and/or justify weight discrimination. PMID: 30941913 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 2, 2019 Category: Eating Disorders & Weight Management Authors: Kersbergen I, Robinson E Tags: Obesity (Silver Spring) Source Type: research

Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems.
CONCLUSIONS: Design differences quantitatively impact the assessment of metabolic end points and thus the qualitative interpretation of various interventions. Importantly, current multiplexed systems remain blind to multiple additional end points, including digestive efficiency and selected forms of energy flux (nitrogenous, anaerobic, etc.), that account for a physiologically and/or pathophysiologically significant fraction of total energy flux. PMID: 30938081 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 2, 2019 Category: Eating Disorders & Weight Management Authors: Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL Tags: Obesity (Silver Spring) Source Type: research

Targeting Autophagy in Obesity-Associated Heart Disease.
san M Abstract Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patien...
Source: Obesity - April 2, 2019 Category: Eating Disorders & Weight Management Authors: Castañeda D, Gabani M, Choi SK, Nguyen QM, Chen C, Mapara A, Kassan A, Gonzalez AA, Ait-Aissa K, Kassan M Tags: Obesity (Silver Spring) Source Type: research

TNF- α Upregulates IKKε Expression via the Lin28B/let-7a Pathway to Induce Catecholamine Resistance in Adipocytes.
CONCLUSIONS: Adipose IKKε expression in children with obesity is substantially elevated and positively correlated with BMI. TNF-α induces catecholamine resistance via activation of the Lin28B/let-7a/IKKε pathway. PMID: 30933434 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 1, 2019 Category: Eating Disorders & Weight Management Authors: Li M, Wang M, Liu Y, Huang S, Yi X, Yin C, Wang S, Zhang M, Yu Q, Li P, Xiao Y Tags: Obesity (Silver Spring) Source Type: research

Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR).
CONCLUSIONS: FXR signaling plays a pivotal role in improved metabolic phenotype following BD surgery. PMID: 30933435 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - April 1, 2019 Category: Eating Disorders & Weight Management Authors: Pierre JF, Li Y, Gomes CK, Rao P, Chang EB, Yin DP Tags: Obesity (Silver Spring) Source Type: research

It's Time for Multidisciplinary Obesity Management Centers.
PMID: 30900404 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Pories WJ, Aronne LJ Tags: Obesity (Silver Spring) Source Type: research

Engaging Fathers in Early Obesity Prevention During the First 1,000 Days: Policy, Systems, and Environmental Change Strategies.
CONCLUSIONS: Increasing father involvement in the specified programs will likely increase their engagement in early obesity prevention in an efficient and sustainable manner. PMID: 30900405 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Davison KK, Gavarkovs A, McBride B, Kotelchuck M, Levy R, Taveras EM Tags: Obesity (Silver Spring) Source Type: research

Meal-Related Acyl and Des-Acyl Ghrelin and Other Appetite-Related Hormones in People with Obesity and Binge Eating.
CONCLUSIONS: In individuals with BE, lower fasting AG may be due to downregulation by habitual overeating, and a smaller postmeal decline in AG may contribute to overeating. Lower postmeal leptin concentrations may also contribute to overeating. PMID: 30900406 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Hernandez D, Mehta N, Geliebter A Tags: Obesity (Silver Spring) Source Type: research

Erratum: Alcohol Intake and Weight Loss During Intensive Lifestyle Intervention for Adults with Overweight or Obesity and Diabetes.
Authors: PMID: 30900407 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Tags: Obesity (Silver Spring) Source Type: research

Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity.
CONCLUSIONS: PAT+Lifestyle decreases weight gain during pregnancy through 12 months post partum in SED African American women with overweight or obesity at the start of pregnancy with minimal additional cost. PMID: 30900408 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Haire-Joshu D, Cahill AG, Stein RI, Todd Cade W, Woolfolk CL, Moley K, Mathur A, Schwarz CD, Schechtman KB, Klein S Tags: Obesity (Silver Spring) Source Type: research

The Combination of Physical Activity and Sedentary Behaviors Modifies the Genetic Predisposition to Obesity.
CONCLUSIONS: This study provides evidence that combined categories of PA and sedentary behaviors modify the extent to which genetic predisposition to obesity results in higher BMI. PMID: 30900409 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Celis-Morales CA, Lyall DM, Bailey MES, Petermann-Rocha F, Anderson J, Ward J, Mackay DF, Welsh P, Pell JP, Sattar N, Gill JMR, Gray SR Tags: Obesity (Silver Spring) Source Type: research

Safety and Effectiveness of Longer-Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort.
Abstract OBJECTIVE: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. METHODS: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months). Multivariable linear models were used to compare percent weight loss across categories at 6, 12, and 24 months, and Cox proportional hazards models were used to compare risk of composite CVD or death, up to 3 year...
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Lewis KH, Fischer H, Ard J, Barton L, Bessesen DH, Daley MF, Desai J, Fitzpatrick SL, Horberg M, Koebnick C, Oshiro C, Yamamoto A, Young DR, Arterburn DE Tags: Obesity (Silver Spring) Source Type: research

Erratum: A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss.
Authors: PMID: 30900411 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Tags: Obesity (Silver Spring) Source Type: research

Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations.
Abstract OBJECTIVE: The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. METHODS: Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed-effects linear regression models were employed to assess main effects and effect...
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Sadr Dadres G, Whitaker KM, Haapala JL, Foster L, Smith KD, Teague AM, Jacobs DR, Kharbanda EO, McGovern PM, Schoenfuss TC, Le LJ, Harnack L, Fields DA, Demerath EW Tags: Obesity (Silver Spring) Source Type: research

End-of-Trial Health Outcomes in Look AHEAD Participants who Elected to have Bariatric Surgery.
CONCLUSIONS: The large, sustained improvements in weight and diabetes observed in this self-selected sample of surgically treated participants are consistent with results of multiple randomized trials. PMID: 30900413 [PubMed - in process] (Source: Obesity)
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Wadden TA, Chao AM, Bahnson JL, Bantle JP, Clark JM, Gaussoin SA, Jakicic JM, Johnson KC, Miller GD, Unick JL, Yanovski SZ, the Look AHEAD Research Group Tags: Obesity (Silver Spring) Source Type: research

Meeting Report on the Conference on Fathers' Role in Children's Weight-Related Behaviors and Outcomes.
Abstract On September 22, 2017, "Engaging the Forgotten Parent: Conference of Experts on Fathers' Role in Children's Weight-Related Behaviours and Outcomes" brought researchers, students, health professionals, community stakeholders, and knowledge users from Canada, Australia, and the United States together to Toronto, Ontario, for a 1-day gathering focused on furthering scientific understanding of effective strategies to recruit, engage, and retain fathers in family-based obesity research. Furthermore this conference focused on identifying key knowledge gaps and opportunities for collaborative research ...
Source: Obesity - March 24, 2019 Category: Eating Disorders & Weight Management Authors: Peeters M, Davison K, Ma D, Haines J Tags: Obesity (Silver Spring) Source Type: research

Assessing the Role of 98 Established Loci for BMI in American Indians.
CONCLUSIONS: In aggregate, European-derived lead SNPs had a notable effect on BMI in Pima Indians. Polygenic obesity in this population manifests strongly in childhood and adolescence and persists throughout much of adult life. PMID: 30887699 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - March 18, 2019 Category: Eating Disorders & Weight Management Authors: Muller YL, Hanson RL, Piaggi P, Chen P, Wiessner G, Okani C, Skelton G, Kobes S, Hsueh WC, Knowler WC, Bogardus C, Baier LJ Tags: Obesity (Silver Spring) Source Type: research

Associations of BMI and Waist Circumference with All-Cause Mortality: A 22-Year Cohort Study.
This study aimed to examine the associations of BMI and waist circumference with all-cause mortality in a general adult population from the China Health and Nutrition Survey. METHODS: Based on the World Health Organization recommendations, the general adult population was divided into underweight (BMI 
Source: Obesity - March 12, 2019 Category: Eating Disorders & Weight Management Authors: Chen Y, Yang Y, Jiang H, Liang X, Wang Y, Lu W Tags: Obesity (Silver Spring) Source Type: research

Leisure-Time Sedentary Behavior and Obesity Among 116,762 Adolescents Aged 12-15  Years from 41 Low- and Middle-Income Countries.
CONCLUSIONS: Being sedentary for ≥ 3 h/d is associated with increased odds of obesity in adolescence. Future longitudinal data are required to confirm these findings and to inform interventions targeting SB among adolescents in LMICs, thereby reducing the prevalence of obesity. PMID: 30859752 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - March 11, 2019 Category: Eating Disorders & Weight Management Authors: Ashdown-Franks G, Vancampfort D, Firth J, Veronese N, Jackson SE, Smith L, Stubbs B, Koyanagi A Tags: Obesity (Silver Spring) Source Type: research

Psychometric Evaluation of the Barriers to Healthy Eating Scale: Results from Four Independent Weight Loss Studies.
Abstract OBJECTIVE: The purpose of this study was to evaluate the psychometric properties of the 22-item Barriers to Healthy Eating (BHE) scale in four independent weight loss studies conducted over 13 years. METHODS: Principal axis factoring with promax rotation was performed to reveal the underlying factor structure. Internal consistency was assessed using Cronbach α, and convergent validity was assessed by correlating the baseline BHE with the Weight Efficacy Lifestyle questionnaire total and subscale scores. Predictive validity was examined by the association of BHE change with weight loss over 6 mo...
Source: Obesity - March 6, 2019 Category: Eating Disorders & Weight Management Authors: Sun R, Rohay JM, Sereika SM, Zheng Y, Yu Y, Burke LE Tags: Obesity (Silver Spring) Source Type: research

Is Doctor Referral to a Low-Energy Total Diet Replacement Program Cost-Effective for the Routine Treatment of Obesity?
CONCLUSIONS: At current retail prices and with plausible long-term weight regain trajectories, TDR is projected to be cost-effective in adults with obesity and could be considered as an option to treat obesity in routine health care settings. PMID: 30801983 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Kent S, Aveyard P, Astbury N, Mihaylova B, Jebb SA Tags: Obesity (Silver Spring) Source Type: research

Physical Activity Energy Expenditure and Total Daily Energy Expenditure in Successful Weight Loss Maintainers.
The objective of this study was to compare physical activity energy expenditure (PAEE) and total daily energy expenditure (TDEE) in successful weight loss maintainers (WLM) with normal weight controls (NC) and controls with overweight/obesity (OC). METHODS: Participants were recruited in three groups: WLM (n = 25, BMI 24.1 ± 2.3 kg/m2 ; maintaining ≥ 13.6-kg weight loss for ≥ 1 year), NC (n = 27, BMI 23.0 ± 2.0 kg/m2 ; similar to current BMI of WLM), and OC (n = 28, BMI 34.3 ± 4.8 kg/m2 ; simila...
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Ostendorf DM, Caldwell AE, Creasy SA, Pan Z, Lyden K, Bergouignan A, MacLean PS, Wyatt HR, Hill JO, Melanson EL, Catenacci VA Tags: Obesity (Silver Spring) Source Type: research

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.
CONCLUSIONS: This study demonstrates that in addition to altered body composition, adiposity-independent mechanisms also contribute to aging-associated insulin resistance in mice and humans. PMID: 30801985 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Ehrhardt N, Cui J, Dagdeviren S, Saengnipanthkul S, Goodridge HS, Kim JK, Lantier L, Guo X, Chen YI, Raffel LJ, Buchanan TA, Hsueh WA, Rotter JI, Goodarzi MO, Péterfy M Tags: Obesity (Silver Spring) Source Type: research

Exercise is the Key to Keeping Weight Off, but What is the Key to Consistently Exercising?
PMID: 30801986 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Church TS, Martin CK Tags: Obesity (Silver Spring) Source Type: research

Shorter Height is Associated with Diabetes in Women but not in Men: Nationally Representative Evidence from Namibia.
CONCLUSIONS: Height is associated with a large reduction in diabetes in women but not in men in Namibia. Interventions that allow women to reach their full growth potential may help prevent the growing diabetes burden in the region. PMID: 30801987 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Koncz V, Geldsetzer P, Manne-Goehler J, Wendt AS, Teufel F, Subramanian SV, Bärnighausen T, De Neve JW Tags: Obesity (Silver Spring) Source Type: research

Increased Expression of Triggering Receptor Expressed on Myeloid Cells-1 in the Population with Obesity and Insulin Resistance.
PMID: 30801988 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Subramanian S, Pallati PK, Rai V, Sharma P, Agrawal DK, Nandipati KC Tags: Obesity (Silver Spring) Source Type: research

Log Often, Lose More: Electronic Dietary Self-Monitoring for Weight Loss.
Abstract OBJECTIVE: Dietary self-monitoring is consistently related to both short- and long-term weight loss. The purpose of this study was to quantify the time spent and the daily frequency of self-monitoring necessary for weight-loss success. METHODS: Participants in a 24-week, online, behavioral weight-control intervention recorded daily dietary intake using a Web-based dietary analysis program. Time spent self-monitoring and frequency of dietary journal page access were captured. Weight loss (kilograms) and the proportion of participants losing ≥ 5% and ≥ 10% of baseline weight were as...
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: Harvey J, Krukowski R, Priest J, West D Tags: Obesity (Silver Spring) Source Type: research

Hidden Figures in Age-Associated Regulation of Glucose Metabolism: Insulin Secretion and Plasma Clearance.
PMID: 30801990 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 27, 2019 Category: Eating Disorders & Weight Management Authors: van Vliet S, Mittendorfer B Tags: Obesity (Silver Spring) Source Type: research

Comparison of Smartphone-Based Behavioral Obesity Treatment With Gold Standard Group Treatment and Control: A Randomized Trial.
CONCLUSIONS: Mobile online delivery of behavioral obesity treatment can achieve weight loss outcomes that are at least as good as those obtained via the more intensive gold standard group-based approach. PMID: 30779333 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 19, 2019 Category: Eating Disorders & Weight Management Authors: Thomas JG, Bond DS, Raynor HA, Papandonatos GD, Wing RR Tags: Obesity (Silver Spring) Source Type: research

Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis.
CONCLUSIONS: UroA plays a direct role in improving systemic insulin sensitivity independent of its parental compounds. This work supports UroA's role in the metabolic benefits of ellagic acid-rich foods and highlights the significance of its microbial transformation in the gut. PMID: 30768775 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 15, 2019 Category: Eating Disorders & Weight Management Authors: Toney AM, Fan R, Xian Y, Chaidez V, Ramer-Tait AE, Chung S Tags: Obesity (Silver Spring) Source Type: research

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial.
CONCLUSIONS: Our findings suggest that red raspberries aid in postmeal glycemic control in individuals with PreDM-IR, reducing glycemic burden with less insulin, which may be related to improved tissue insulin sensitivity. PMID: 30767409 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 14, 2019 Category: Eating Disorders & Weight Management Authors: Xiao D, Zhu L, Edirisinghe I, Fareed J, Brailovsky Y, Burton-Freeman B Tags: Obesity (Silver Spring) Source Type: research

Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.
CONCLUSIONS: A moderate polygenic contribution to adiposity in rhesus macaques was found, as well as mutations with potentially larger effects in multiple genes that influence obesity in humans. PMID: 30741480 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 11, 2019 Category: Eating Disorders & Weight Management Authors: Raboin MJ, Letaw J, Mitchell AD, Toffey D, McKelvey J, Roberts CT, Curran JE, Vinson A Tags: Obesity (Silver Spring) Source Type: research

Vertical Sleeve Gastrectomy Attenuates Hedonic Feeding Without Impacting Alcohol Drinking in Rats.
CONCLUSIONS: VSG attenuated hedonic feeding without impacting alcohol drinking, an effect potentially mediated by alterations in genetic information flow within the hypothalamus. Importantly, these data highlight VSG as an effective bariatric procedure with a potentially reduced risk of developing alcohol use disorder. PMID: 30740914 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 10, 2019 Category: Eating Disorders & Weight Management Authors: Sirohi S, Skripnikova E, Davis JF Tags: Obesity (Silver Spring) Source Type: research