Continued Decline in Obesity and Severe Obesity Prevalence Among New York City Public School Youth in Grades K-8: 2011-2017.
This study aimed to estimate population-level prevalence of obesity and severe obesity for New York City youth and examine the most recent trends over time. METHODS: All public school youth in grades kindergarten through eighth (K-8) (2011-2012 through 2016-2017) with valid weight and height measures were included (N = 1,137,782 unique students; 3,720,297 observations). Age- and sex-specific BMI percentiles for obesity and severe obesity were estimated using Centers for Disease Control and Prevention growth charts. Repeated cross-sectional analyses were conducted using logistic regression, weighting for ...
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Day SE, D'Agostino EM, Huang TT, Larkin M, Harr L, Konty KJ Tags: Obesity (Silver Spring) Source Type: research

Thirty-Year Risk of Cardiovascular Disease Events in Adolescents with Severe Obesity.
This study examined the 30-year CVD event risk among adolescents with severe obesity treated with and without metabolic and bariatric surgery (MBS), compared with youths with moderate obesity, overweight, or normal weight. METHODS: Cross-sectional and longitudinal comparisons of five frequency-matched (age and diabetes status) groups were performed: normal weight (n = 247), overweight (n = 54), obesity (n = 131), severe obesity without MBS (n = 302), and severe obesity undergoing MBS (n = 215). A 30-year CVD event score developed by the Framingham H...
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Ryder JR, Xu P, Inge TH, Xie C, Jenkins TM, Hur C, Lee M, Choi J, Michalsky MP, Kelly AS, Urbina EM Tags: Obesity (Silver Spring) Source Type: research

Altered Interactions Among Resting-State Networks in Individuals with Obesity.
Abstract OBJECTIVE: The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting-state networks involved in salience, executive control, and interoception in participants with obesity (OB). METHODS: Using resting-state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting-state networks in 35 OB and 35 normal-weight controls (NW) were investigated. RESULTS: Compared with NW, OB showed reduced FC strength in the ventromedial prefrontal cortex and posterior ci...
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Ding Y, Ji G, Li G, Zhang W, Hu Y, Liu L, Wang Y, Hu C, von Deneen KM, Han Y, Cui G, Wang H, Wiers CE, Manza P, Tomasi D, Volkow ND, Nie Y, Wang GJ, Zhang Y Tags: Obesity (Silver Spring) Source Type: research

Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED-Plus Study.
L, Estruch R, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, García Molina L, Gaforio JJ, Matía-Martín P, Daimiel L, Martín Sánchez V, Vidal J, Prieto L, Ros E, Goñi N, Babio N, Ortega-Azorin C, Castañer O, Konieczna J, Notario Barandiaran L, Vaquero-Luna J, Benavente-Marín JC, Zulet MA, Sanchez-Villegas A, Sacanella E, Gómez Huelgas R, Miró-Moriano L, Gimenez-Gracia M, Julibert A, Razquin C, Basora J, Portolés O, Goday A, Galmés-Panadés AM, López-García CM, Moreno-Rodriguez A, Toledo E, Díaz-López A, ...
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Fernández-García JC, Muñoz-Garach A, Martínez-González MÁ, Salas-Salvado J, Corella D, Hernáez Á, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, García Mo Tags: Obesity (Silver Spring) Source Type: research

Transgenerational Studies: How Do We Investigate Multigenerational Effects?
PMID: 32090512 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Harville EW, Kartiosuo N Tags: Obesity (Silver Spring) Source Type: research

Proposal for a Scientifically Correct and Medically Actionable Disease Classification System (ICD) for Obesity.
CONCLUSIONS: The scientifically correct and medically actionable approach to diagnosis and disease coding will lead to greater acknowledgement of ABCD as a disease and accessibility to evidence-based therapies on behalf of patients across the life cycle. PMID: 32090513 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Garvey WT, Mechanick JI Tags: Obesity (Silver Spring) Source Type: research

Our Definition of Obesity and its Impact on Treatment.
PMID: 32090514 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Hebebrand J Tags: Obesity (Silver Spring) Source Type: research

MicroRNA Profiling in Adipose Before and After Weight Loss Highlights the Role of miR-223-3p and the NLRP3 Inflammasome.
CONCLUSIONS: This is the first report detailing genome-wide miRNA profiling of omental adipose before and after gastric bypass, and it further highlights the association of miR-223-3p and the NLRP3 inflammasome with obesity. PMID: 32090515 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Macartney-Coxson D, Danielson K, Clapham J, Benton MC, Johnston A, Jones A, Shaw O, Hagan RD, Hoffman EP, Hayes M, Harper J, Langston MA, Stubbs RS Tags: Obesity (Silver Spring) Source Type: research

Levels of Circulating miR-122 are Associated with Weight Loss and Metabolic Syndrome.
This study investigated whether the levels of specific serum microRNAs (miRNAs) were altered following diet-induced weight loss and whether the serum miRNAs differed in the presence of the metabolic syndrome. METHODS: The study was a weight loss intervention trial with a prescribed energy deficit of approximately 500 kcal/d. Levels of 22 miRNAs were determined in serum samples from 85 participants with overweight or obesity. miRNAs were analyzed using TaqMan Array miRNA Cards and normalized to the geometric mean of spiked-in ath-miR-159a and U6 small nuclear RNA using the ΔCT method. RESULTS: The avera...
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Hess AL, Larsen LH, Udesen PB, Sanz Y, Larsen TM, Dalgaard LT Tags: Obesity (Silver Spring) Source Type: research

Liraglutide 3.0 mg and Intensive Behavioral Therapy (IBT) for Obesity in Primary Care: The SCALE IBT Randomized Controlled Trial.
CONCLUSIONS: In a primary care setting, Centers for Medicare and Medicaid Services-based IBT produced clinically meaningful weight loss at 56 weeks, enhanced by the addition of liraglutide 3.0 mg. PMID: 32090517 [PubMed - in process] (Source: Obesity)
Source: Obesity - February 25, 2020 Category: Eating Disorders & Weight Management Authors: Wadden TA, Tronieri JS, Sugimoto D, Lund MT, Auerbach P, Jensen C, Rubino D Tags: Obesity (Silver Spring) Source Type: research

Measures of Adipose Tissue Redistribution and Atherosclerotic Coronary Plaque in HIV.
Abstract OBJECTIVE: People with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD). The relationship between adipose compartments and coronary disease is not well understood among PWH. METHODS: A total of 148 PWH and 68 uninfected individuals without CVD were well phenotyped for VAT and SAT via single-section abdominal computed tomography (CT) at L4. Coronary artery calcium (CAC) score was assessed by non...
Source: Obesity - February 21, 2020 Category: Eating Disorders & Weight Management Authors: Bogorodskaya M, Fitch KV, Lu M, Torriani M, Zanni MV, Looby SE, Iyengar S, Triant VA, Grinspoon SK, Srinivasa S, Lo J Tags: Obesity (Silver Spring) Source Type: research

Striatal Dopamine Responses to Feeding are Altered in People with Obesity.
This study determined whether striatal dopamine (DA) release is affected by food ingestion and whether the DA response to high-calorie food images is greater in the fasted than in the fed state in people with obesity. METHODS: Striatal DA release was evaluated in 10 people with obesity and prediabetes after consuming a meal to satiation and after fasting overnight as well as in response to viewing images of high-calorie compared with low-calorie foods after consuming a meal to satiation or fasting overnight by using positron emission tomography with [11 C]raclopride injection. RESULTS: Striatal DA ...
Source: Obesity - February 21, 2020 Category: Eating Disorders & Weight Management Authors: Eisenstein SA, Black KJ, Samara A, Koller JM, Dunn JP, Hershey T, Klein S, Smith GI Tags: Obesity (Silver Spring) Source Type: research

Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity.
CONCLUSIONS: Protein components of the OXPHOS machinery are systematically downregulated in adipose tissues of DIO mice compared with lean mice. Loss of the mitochondrial OXPHOS capacity in adipocytes may aggravate the development of metabolic disease. PMID: 32034895 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 7, 2020 Category: Eating Disorders & Weight Management Authors: Schöttl T, Pachl F, Giesbertz P, Daniel H, Kuster B, Fromme T, Klingenspor M Tags: Obesity (Silver Spring) Source Type: research

Examining Heterogeneity of Outcomes in a Weight Gain Prevention Program for Young Adults.
CONCLUSIONS: Large Gainers (representing almost 10% of participants) could be identified early by greater weight issues at baseline and lower use of weight gain prevention strategies. PMID: 32030910 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Wing RR, Russell GB, Tate DF, Espeland MA, LaRose JG, Gorin AA, Lewis CE, Jelalian E, Perdue LH, Bahnson J, Polzien K, Ferguson Robichaud E, Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group Tags: Obesity (Silver Spring) Source Type: research

Increased Visceral Adipose Tissue Without Weight Retention at 59 Weeks Postpartum.
This study aimed to determine whether controlling maternal gestational weight gain (GWG) influences adipose tissue distribution at 1 year postpartum. METHODS: Women with overweight or obesity (n = 210, BMI ≥ 25 or ≥ 30) were randomized to a lifestyle intervention (LI) designed to control GWG or to usual obstetrical care (UC). Measures included anthropometry, whole-body magnetic resonance imaging for visceral (VAT), intermuscular, and subcutaneous adipose tissue, and cardiometabolic risk factors in pregnancy (15 and 35 weeks) and after delivery (15 and 59 weeks). ...
Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Janumala I, Toro-Ramos T, Widen E, Rosenn B, Crane J, Horowitz M, Lin S, Gidwani S, Paley C, Thornton JC, Pi-Sunyer FX, Gallagher D Tags: Obesity (Silver Spring) Source Type: research

Low Serum Insulinlike Growth Factor  II Levels Correlate with High BMI in American Indian Adults.
CONCLUSIONS: There is a negative relationship between IGF-II levels and BMI, in which the correlation is stronger at older ages. The association between genetic risk for BMI and IGF-II levels suggests that this correlation may be due to an effect of obesity on IGF-II. PMID: 32030914 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Muller YL, Hanson RL, Mahkee D, Piaggi P, Kobes S, Hsueh WC, Knowler WC, Bogardus C, Baier LJ Tags: Obesity (Silver Spring) Source Type: research

Stress is Associated with Adiposity in Parents of Young Children.
CONCLUSIONS: General stress, parenting distress, and household chaos are associated with adiposity among parents of young children. Future research should elucidate mechanisms by which this occurs and elucidate how this risk may be mitigated. PMID: 32030916 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Hruska V, Ambrose T, Darlington G, Ma DWL, Haines J, Buchholz AC, Guelph Family Health Study Tags: Obesity (Silver Spring) Source Type: research

Maternal Adiposity is Associated with Fat Mass Accretion in Female but not Male Offspring During the First 2 Years of Life.
This study investigated which antenatal and postnatal factors determine offspring adiposity during the first 2 years of life. METHODS: Participants were mother and child pairs (N = 224). Offspring percent fat mass (%FM) was obtained using quantitative nuclear magnetic resonance at 11 time points between ages 0.5 and 24 months. Independent variables included race, age, gestational weight gain, first-trimester %FM, delivery mode, gestational measures of resting energy expenditure, respiratory exchange ratio, physical activity, serum cytokines and lipids, and dietary intake for the mothers, as well as sex, ...
Source: Obesity - February 6, 2020 Category: Eating Disorders & Weight Management Authors: Heard-Lipsmeyer ME, Diaz EC, Sims CR, Sobik SR, Ruebel ML, Thakali KM, Krukowski RA, Cleves M, Børsheim E, Shankar K, Andres A Tags: Obesity (Silver Spring) Source Type: research

Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling.
Abstract OBJECTIVE: Interleukin (IL)-1β is involved in obesity-associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL-1β and caspase-1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery. METHODS: A total of 32 patients with morbid obesity and T2D (Ob-T2D) and 29 patients with morbid obesity and normal glucose tolerance (Ob-NGT), treated by Roux-en-Y gastric bypass, were studied before and 1 year after surgery. Sixteen healthy individuals served as a control (HC) group. IR was assessed by the o...
Source: Obesity - February 5, 2020 Category: Eating Disorders & Weight Management Authors: Antonioli L, Moriconi D, Masi S, Bottazzo D, Pellegrini C, Fornai M, Anselmino M, Ferrannini E, Blandizzi C, Taddei S, Nannipieri M Tags: Obesity (Silver Spring) Source Type: research

Impact of a Policy to Deliver at 39 Weeks for the Indication of Class III Obesity.
CONCLUSIONS: A policy of delivery at 39 weeks for class III obesity did not affect overall cesarean rate or rates of maternal or neonatal morbidity. Further investigation should evaluate subsets of women who may have a higher cesarean rate with this policy. PMID: 32020789 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 5, 2020 Category: Eating Disorders & Weight Management Authors: Pierce SL, Maxted ME, Peck JD, Lutz JS, Lopez-Davila MF, Vieira F, Atchley CB, Edwards RK Tags: Obesity (Silver Spring) Source Type: research

Alterations of Serum Ser312-Phosphorylated Fetuin-A from Exercise-Induced Moderate Body Weight Loss in Individuals with Obesity.
CONCLUSIONS: This study reports for the first time that the insulin-sensitizing effects of moderate weight loss are associated with a reduction in serum pFet-A levels. PMID: 32012464 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 3, 2020 Category: Eating Disorders & Weight Management Authors: Ren G, Bowers RL, Kim T, Araya-Ramirez F, Mahurin AJ, Dean DM, Grandjean PW, Mathews ST Tags: Obesity (Silver Spring) Source Type: research

Maternal Birth Weight and BMI Mediate the Transgenerational Effect of Grandmaternal BMI on Grandchild's Birth Weight.
CONCLUSIONS: Larger grandmaternal BMI indirectly increased grandchild's BW via maternal BW and BMI. Grandmaternal smoking during pregnancy indirectly reduced grandchild's BW via maternal smoking during pregnancy and BW. PMID: 32012478 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 3, 2020 Category: Eating Disorders & Weight Management Authors: Shen Y, Zhang H, Jiang Y, Mzayek F, Arshad H, Karmaus W Tags: Obesity (Silver Spring) Source Type: research

Sexually Dimorphic Effects of Dietary Methionine Restriction are Dependent on Age when the Diet is Introduced.
CONCLUSIONS: The sexually dimorphic effects of MR are limited to nutrient partitioning between lean and fat tissue deposition in young, growing mice. Introduction of the diet after physical maturity produced comparable effects on growth and metabolic responses in male and female mice. PMID: 32012481 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 3, 2020 Category: Eating Disorders & Weight Management Authors: Forney LA, Stone KP, Gibson AN, Vick AM, Sims LC, Fang H, Gettys TW Tags: Obesity (Silver Spring) Source Type: research

Association of Changes in Physical Activity and Incidence and Remission of Overall and Abdominal Obesity in 113,950 Adults.
CONCLUSIONS: Increasing PA was consistently associated with a progressively lower incidence and higher remission of overall and abdominal obesity. PMID: 32012483 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - February 3, 2020 Category: Eating Disorders & Weight Management Authors: Martinez-Gomez D, Hamer M, Ortega FB, Cabanas-Sanchez V, Sadarangani KP, Lavie CJ, Rodríguez-Artalejo F Tags: Obesity (Silver Spring) Source Type: research

The Underappreciated Synergy of Strength Training.
PMID: 31970903 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Church TS Tags: Obesity (Silver Spring) Source Type: research

New Concerns About Military  Recruits with Metabolic Obesity but Normal Weight ("Skinny Fat").
New Concerns About Military Recruits with Metabolic Obesity but Normal Weight ("Skinny Fat"). Obesity (Silver Spring). 2020 Feb;28(2):223 Authors: Foulis SA, Hughes JM, Friedl KE PMID: 31970904 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Foulis SA, Hughes JM, Friedl KE Tags: Obesity (Silver Spring) Source Type: research

Predicted Lifetime Third-Party Costs of Obesity for Black and White Adolescents with Race-Specific Age-Related Weight Gain.
CONCLUSIONS: A substantial portion of obesity's prevalence, and therefore cost, for black males and females comes from age-related weight gain in early adulthood. This speaks to the persistent threat of obesity beyond adolescence for this demographic, and further research should focus on whether policy can modify the behaviors and environment through which and in which this sharp increase in weight occurs. PMID: 31970905 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Schell RC, Just DR, Levitsky DA Tags: Obesity (Silver Spring) Source Type: research

Appetite-Related Responses to Overfeeding and Longitudinal Weight Change in Obesity-Prone and Obesity-Resistant Adults.
Abstract OBJECTIVE: Appetite responses to 3 days of overfeeding (OF) were examined as correlates of longitudinal weight change in adults classified as obesity prone (OP) or obesity resistant (OR). METHODS: OP (n = 22) and OR (n = 30) adults consumed a controlled eucaloric and OF diet (140% of energy needs) for 3 days, followed by 3 days of ad libitum feeding. Hunger and satiety were evaluated by visual analog scales. Ghrelin and peptide YY (PYY) levels were measured during a 24-hour inpatient visit on day 3. Body weight and composition were measured annually for 4.0 &pl...
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Halliday TM, Rynders CA, Thomas E, Bergouignan A, Pan Z, Kealey EH, Cornier MA, Bessesen DH Tags: Obesity (Silver Spring) Source Type: research

Sexual Dimorphisms in Adult Human Brown Adipose Tissue.
CONCLUSIONS: Despite differences in adiposity and total BAT volume, we found that healthy, lean, young women and men do not differ in the relative amount, glucose uptake, and distribution of BAT. Dorsocervical 18 F-fluorodeoxyglucose uptake was more prevalent in women and may be a remnant of interscapular BAT seen in human newborns. Future studies are needed to discern how BAT contributes to whole-body thermal physiology and body weight regulation in women and men. PMID: 31970907 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Fletcher LA, Kim K, Leitner BP, Cassimatis TM, O'Mara AE, Johnson JW, Halprin MS, McGehee SM, Brychta RJ, Cypess AM, Chen KY Tags: Obesity (Silver Spring) Source Type: research

Association of Hot Tea Consumption with Regional Adiposity Measured by Dual-Energy X-Ray Absorptiometry in NHANES 2003-2006.
CONCLUSIONS: Consumption of hot tea might be considered as part of a healthy diet in order to support parameters associated with metabolic health and may be particularly important in older male age groups in supporting reduced central adiposity. PMID: 31970908 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Roberts J, Liu Q, Cao C, Jackson SE, Zong X, Meyer GA, Yang L, Cade WT, Zheng X, López-Sánchez GF, Wu X, Smith L Tags: Obesity (Silver Spring) Source Type: research

Association Between Life-Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort.
CONCLUSIONS: Current and past obesity appear to be important determinants of frailty. Early weight management may be beneficial in old age. PMID: 31970909 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Landré B, Czernichow S, Goldberg M, Zins M, Ankri J, Herr M Tags: Obesity (Silver Spring) Source Type: research

Genetically Engineered Escherichia coli Nissle 1917 Secreting GLP-1 Analog Exhibits Potential Antiobesity Effect in High-Fat Diet-Induced  Obesity Mice.
CONCLUSIONS: This work has revealed that a modified live bacterial therapeutic, EcN-GM, has potential beneficial effects on obesity. This effect may be related to the regulating of the neuropeptide expression of energy intake and expenditure in the hypothalamus. This study demonstrates a successful example of engineered EcN-GM as a novel approach for weight management. PMID: 31970910 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Ma J, Li C, Wang J, Gu J Tags: Obesity (Silver Spring) Source Type: research

Response to "Time to Seek a More Personalized Approach to Bariatric Surgery".
Response to "Time to Seek a More Personalized Approach to Bariatric Surgery". Obesity (Silver Spring). 2020 Feb;28(2):222 Authors: Bhandari M, Fobi M, Mathur W, Kosta S PMID: 31970911 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Bhandari M, Fobi M, Mathur W, Kosta S Tags: Obesity (Silver Spring) Source Type: research

Behavioral and Psychological Strategies of Long-Term Weight Loss Maintainers in a Widely Available Weight Management Program.
Abstract OBJECTIVE: The study's purpose was to use validated questionnaires to identify novel behavioral and psychological strategies among weight loss maintainers (WLMs) in a commercial weight management program. METHODS: Participants were 4,786 WLMs in WW (formerly Weight Watchers, New York, New York) who had maintained weight loss  ≥ 9.1 kg (24.7 kg/23.8% weight loss on average) for 3.3 years and had a current mean BMI of 27.6 kg/m2 . A control group of 528 weight-stable individuals with obesity had a mean BMI of 38.9 kg/m2 and weight change  
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Phelan S, Halfman T, Pinto AM, Foster GD Tags: Obesity (Silver Spring) Source Type: research

Mitochondrial Pyruvate Carriers are not Required for Adipogenesis but are  Regulated by High-Fat Feeding in Brown Adipose Tissue.
CONCLUSIONS: Although MPCs are essential for pyruvate transport, MPCs are not required for adipogenesis in vitro, suggesting that other substrates can be used for energy production when the MPC complex is not functional. Also, a significant decrease in MPC1 and 2 expression occurred in brown fat, but not white fat, of male mice fed an HFD. PMID: 31970913 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Burrell JA, Richard AJ, King WT, Stephens JM Tags: Obesity (Silver Spring) Source Type: research

BMI and Medically Certified Long-Term Sickness Absence Among Japanese Employees.
CONCLUSIONS: In a cohort of the Japanese working-age population, both obesity and underweight were associated with a greater risk of LTSA in males. Future research should not overlook the excess risk of LTSA associated with underweight. PMID: 31970914 [PubMed - in process] (Source: Obesity)
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Endo M, Inoue Y, Kuwahara K, Nishiura C, Hori A, Ogasawara T, Yamaguchi M, Nakagawa T, Honda T, Yamamoto S, Okazaki H, Imai T, Nishihara A, Miyamoto T, Sasaki N, Uehara A, Yamamoto M, Murakami T, Shimizu M, Eguchi M, Kochi T, Nagahama S, Tomita K, Kunugit Tags: Obesity (Silver Spring) Source Type: research

Longitudinal Study of Maternal BMI in Successive Pregnancies.
Abstract OBJECTIVE: This longitudinal observational study examined BMI changes between successive pregnancies. METHODS: The computerized medical records of women who attended a large maternity hospital between 2009 and 2017 for their first and second singleton deliveries were analyzed. Women who had their weight first measured after 15 weeks of gestation in either pregnancy were excluded. RESULTS: Of the 9,724 women, the incidence of obesity increased from 11.6% in the first pregnancy to 16.0% in the second. The mean interpregnancy interval was 32.5 ± 15.7 months, and median BMI...
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Reynolds CME, Egan B, O'Malley EG, McMahon L, Sheehan SR, Turner MJ Tags: Obesity (Silver Spring) Source Type: research

Early Infant Feeding and BMI Trajectories in the First 5 Years of Life.
This study examined the relative impact of breastfeeding duration and timing of solids introduction on BMI z score (BMIz) trajectory in early childhood. METHODS: This study conducted secondary analyses of data from the Melbourne Infant Feeding, Activity and Nutrition Trial (InFANT) Program (N = 542), a prospective cohort study with data collected at birth and 3, 9, 18, 42, and 60 months. Linear spline multilevel models were performed. RESULTS: Differential growth rates were observed from birth to 3 months and from 9 to 18 months by breastfeeding duration (≥ 6 vs.
Source: Obesity - January 25, 2020 Category: Eating Disorders & Weight Management Authors: Zheng M, Cameron AJ, Birken CS, Keown-Stoneman C, Laws R, Wen LM, Campbell KJ Tags: Obesity (Silver Spring) Source Type: research

Mobile Application Interventions and Weight Loss in Type 2 Diabetes: A Meta-Analysis.
CONCLUSIONS: Mobile app interventions lead to weight loss in patients with type 2 diabetes and are worth recommending for weight loss promotion. PMID: 31965748 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 22, 2020 Category: Eating Disorders & Weight Management Authors: Cai X, Qiu S, Luo D, Wang L, Lu Y, Li M Tags: Obesity (Silver Spring) Source Type: research

Physical Activity and Adiposity in a Racially Diverse Cohort of US Infants.
anu C Abstract OBJECTIVE: Early life physical activity may help prevent obesity, but objective quantification in infants is challenging. METHODS: A total of 506 infants were examined from 2013 to 2016. Infants wore accelerometers for 4 days at ages 3, 6, 9, and 12 months. Daily log-transformed physical activity counts were computed, averaged, and standardized across assessments. A linear mixed model was used to examine trends in standardized physical activity counts as well as associations between physical activity and BMI z score, sum of subscapular and triceps skinfold thickness for overall adiposity (SS+TR...
Source: Obesity - January 16, 2020 Category: Eating Disorders & Weight Management Authors: Benjamin-Neelon SE, Bai J, Østbye T, Neelon B, Pate RR, Crainiceanu C Tags: Obesity (Silver Spring) Source Type: research

Comparing the Ability of Two Comprehensive Clinical Staging Systems to Predict Mortality: EOSS and CMDS.
CONCLUSIONS: CMDS had statistically significantly greater predictive and discriminative ability than EOSS for persons aged 40 to 75. While the clinical relevance of these differences is unknown, CMDS may have greater clinical utility given that it uses fewer items to risk stratify. The clinical relevance and utility need to be studied further. PMID: 31905265 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 6, 2020 Category: Eating Disorders & Weight Management Authors: Ejima K, Xavier NA, Mehta T Tags: Obesity (Silver Spring) Source Type: research

Time to Seek a More Personalized Approach to Bariatric Surgery.
PMID: 31903718 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 5, 2020 Category: Eating Disorders & Weight Management Authors: Moon RC Tags: Obesity (Silver Spring) Source Type: research

Transendothelial Insulin Transport is Impaired in Skeletal Muscle Capillaries of Obese Male Mice.
CONCLUSIONS: These results suggest that, in male mice, obesity results in ultrastructural alterations to the capillary endothelium that delay EIT. Nonetheless, the myocyte appears to exceed the endothelium as a contributor to SkM IR in DIO male mice. PMID: 31903723 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 5, 2020 Category: Eating Disorders & Weight Management Authors: Williams IM, McClatchey PM, Bracy DP, Bonner JS, Valenzuela FA, Wasserman DH Tags: Obesity (Silver Spring) Source Type: research

Impact of Life Events on Short-Term Change in BMI in Early and Middle Childhood.
CONCLUSIONS: No significant change in BMI z score was observed in 1 to 2 years for children experiencing many life events. PMID: 31903732 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 5, 2020 Category: Eating Disorders & Weight Management Authors: Weber ZA, Shoben A, Anderson SE Tags: Obesity (Silver Spring) Source Type: research

Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders.
Abstract Obesity is one of the most serious global health problems, with an incidence that increases yearly and coincides with the development of a variety of associated comorbidities (e.g., type 2 diabetes, nonalcoholic fatty liver disease, some immune-related disorders). Although many studies have investigated the pathogenesis of overweight and obesity, multiple regulatory factors underlying the onset of obesity-related metabolic disorders remain elusive. Macrophages contribute to modulation of obesity-related inflammation and insulin resistance (IR); adipose tissue macrophages are particularly important in this...
Source: Obesity - January 5, 2020 Category: Eating Disorders & Weight Management Authors: Ni Y, Ni L, Zhuge F, Xu L, Fu Z, Ota T Tags: Obesity (Silver Spring) Source Type: research

Comparison of Anthropometric Measures in US Military Personnel in the Classification of Overweight and Obesity.
CONCLUSIONS: Our findings support BMI + CBE as an easy-to-implement combination to assess adiposity in the military. PMID: 31904192 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 5, 2020 Category: Eating Disorders & Weight Management Authors: Shams-White MM, Chui K, Deuster PA, McKeown NM, Must A Tags: Obesity (Silver Spring) Source Type: research

Magnetic Resonance Imaging and Bioelectrical Impedance Analysis to Assess Visceral and Abdominal Adipose Tissue.
CONCLUSIONS: Visceral BIA measurements agreed better with MRI measurements of the total abdomen than of the visceral compartment, indicating that BIA visceral fat area assessment cannot differentiate adipose tissue between visceral and abdominal compartments in young and older participants. PMID: 31898402 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 3, 2020 Category: Eating Disorders & Weight Management Authors: Chaudry O, Grimm A, Friedberger A, Kemmler W, Uder M, Jakob F, Quick HH, von Stengel S, Engelke K Tags: Obesity (Silver Spring) Source Type: research

Pentraxin 3 Regulates miR-21 Expression and Secretion in Brown Adipocytes During Lipopolysaccharide-Induced Inflammation.
CONCLUSIONS: PTX3 plays an anti-inflammatory role, in part through regulating miR-21 expression and secretion. PMID: 31898407 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 3, 2020 Category: Eating Disorders & Weight Management Authors: Lin T, Guo H, Chen X Tags: Obesity (Silver Spring) Source Type: research

History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial.
CONCLUSIONS: Intervention response heterogeneity was significant for nonfatal MI. Response heterogeneity may need consideration in a CVD-outcome trial design. PMID: 31898874 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - January 3, 2020 Category: Eating Disorders & Weight Management Authors: Look AHEAD Research Group, Lewis CE, Bantle JP, Bertoni AG, Blackburn G, Brancati FL, Bray GA, Cheskin LJ, Curtis JM, Egan C, Evans M, Foreyt JP, Ghazarian S, Barone Gibbs B, Glasser SP, W Gregg E, Hazuda HP, Hesson L, Hill JO, Horton ES, Hubbard VS, Jaki Tags: Obesity (Silver Spring) Source Type: research

Weight Gain Over 6 Years in Young Adults: The Study of Novel Approaches to Weight Gain Prevention Randomized Trial.
Abstract OBJECTIVE: The study objective was to determine whether two self-regulation interventions that reduced 3-year weight gain in young adults remain effective at 6 years. METHODS: A randomized trial was conducted in two academic settings in 599 young adults, aged 18 to 35 years, with normal weight or overweight; 504 (84%) reconsented for a 6-year extension (Study of Novel Approaches to Weight Gain Prevention-Extended [SNAP-E]) with ongoing intervention and assessments. Weight gain over 6 years was compared for all assigned to Control, Large Changes (LC; lose 5-10 pounds initially), an...
Source: Obesity - December 22, 2019 Category: Eating Disorders & Weight Management Authors: Wing RR, Espeland MA, Tate DF, Perdue LH, Bahnson J, Polzien K, Robichaud EF, LaRose JG, Gorin AA, Lewis CE, Jelalian E, Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group Tags: Obesity (Silver Spring) Source Type: research