Global Coagulation Assessment in Cirrhosis and ACLF
Conditions:   Acute-On-Chronic Liver Failure;   Cirrhosis, Liver Intervention:   Sponsor:   Postgraduate Institute of Medical Education and Research Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 2, 2020 Category: Research Source Type: clinical trials

Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Condition:   Depression in Chronic Hepatitis C Intervention:   Other: Depression and Cognitive Tests Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial
Conditions:   Periodontal Diseases;   Cirrhosis Interventions:   Procedure: Periodontal therapy;   Procedure: Oral hygiene advice Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

COVID-19 in Patients With Pre-existing Cirrhosis (COVID-Cirrhosis-CHESS2002): A Multicentre Observational Study
Conditions:   COVID-19;   Liver Cirrhosis Intervention:   Sponsors:   Hepatopancreatobiliary Surgery Institute of Gansu Province;   Renmin Hospital of Wuhan University;   LanZhou University;   Minda Hospital Affiliated to Hubei University for Nationalities;   Wuhan Union Hospital, China;   The Central Hospital of Enshi Tujia And Miao Autonomous Prefec ture;   Tianjin Second People's Hospital;   Sixth People’s Hospital of Shenyang;   Guangxi Zhuang Autonomous Region...
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Condition:   Depression in Chronic Hepatitis C Intervention:   Other: Depression and Cognitive Tests Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial
Conditions:   Periodontal Diseases;   Cirrhosis Interventions:   Procedure: Periodontal therapy;   Procedure: Oral hygiene advice Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

COVID-19 in Patients With Pre-existing Cirrhosis (COVID-Cirrhosis-CHESS2002): A Multicentre Observational Study
Conditions:   COVID-19;   Liver Cirrhosis Intervention:   Sponsors:   Hepatopancreatobiliary Surgery Institute of Gansu Province;   Renmin Hospital of Wuhan University;   LanZhou University;   Minda Hospital Affiliated to Hubei University for Nationalities;   Wuhan Union Hospital, China;   The Central Hospital of Enshi Tujia And Miao Autonomous Prefec ture;   Tianjin Second People's Hospital;   Sixth People’s Hospital of Shenyang;   Guangxi Zhuang Autonomous Region...
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial
Condition:   Depression in Chronic Hepatitis C Intervention:   Other: Depression and Cognitive Tests Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial
Conditions:   Periodontal Diseases;   Cirrhosis Interventions:   Procedure: Periodontal therapy;   Procedure: Oral hygiene advice Sponsor:   Postgraduate Institute of Medical Education and Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

COVID-19 in Patients With Pre-existing Cirrhosis (COVID-Cirrhosis-CHESS2002): A Multicentre Observational Study
Conditions:   COVID-19;   Liver Cirrhosis Intervention:   Sponsors:   Hepatopancreatobiliary Surgery Institute of Gansu Province;   Renmin Hospital of Wuhan University;   LanZhou University;   Minda Hospital Affiliated to Hubei University for Nationalities;   Wuhan Union Hospital, China;   The Central Hospital of Enshi Tujia And Miao Autonomous Prefec ture;   Tianjin Second People's Hospital;   Sixth People’s Hospital of Shenyang;   Guangxi Zhuang Autonomous Region...
Source: ClinicalTrials.gov - April 1, 2020 Category: Research Source Type: clinical trials

The Utility of Breath Biopsy as a Screening Tool for HCC
Conditions:   HCC;   Cirrhosis, Liver Intervention:   Diagnostic Test: Breath Biopsy Sponsor:   University of Aberdeen Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 30, 2020 Category: Research Source Type: clinical trials

Continuous Passive Paracentesis for Intra-abdominal Hypertension
Conditions:   Ascites Hepatic;   Cirrhosis, Liver;   Hypertension, Intraabdominal;   Critical Illness;   Paracentesis Interventions:   Device: continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter;   Procedure: Ultrasound-guided intermittent large-volume paracentesis Sponsors:   Centro Hospitalar de Lisboa Central;   NOVA Medical School Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 26, 2020 Category: Research Source Type: clinical trials

Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial
This study aims to investigate the effect of periodontal treatment for liver damage,P. gingivalis infection, and endotoxemia on patients with NAFLD.MethodsWe will include adult patients (20 –85 years old) with NAFLD, alanine aminotransferase (ALT) ≥ 40 IU/L, and equivalent steatosis grade ≥ 1 (target sample size,n = 40 patients; planned number of patients with outcome data,n = 32). Participants will be randomly assigned to one of two groups: a scaling and root-planing group or tooth-brushing as the usual group. The primary outcome will be the change...
Source: Trials - March 23, 2020 Category: Research Source Type: clinical trials

Refractory Ascites in Patients With Liver Cirrhosis, and the Potential Treatment With 48 Hours Infusion of Ularitide.
Conditions:   Cirrhosis, Liver;   Ascites Hepatic Interventions:   Drug: Ularitide;   Drug: Placebo Sponsors:   University of Aarhus;   Aarhus University Hospital;   ADS AIPHIA Development Services AG Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 17, 2020 Category: Research Source Type: clinical trials

Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
Conditions:   Chronic Pancreatitis;   Inflammatory Bowel Diseases;   Hepatitis;   NASH - Nonalcoholic Steatohepatitis;   Acute Pancreatitis;   Rheumatoid Arthritis;   Diabetes Mellitus;   Dyslipidemias;   Multiple Sclerosis;   Irritable Bowel Syndrome;   Chronic Pain;   Chronic Diseas e;   Chronic Kidney Diseases;   Crohn Disease;   Celiac Disease;   Biliary Cirrhosis;   Bile Acid Synthesis Defect;   Gastritis;   Cholecys...
Source: ClinicalTrials.gov - March 13, 2020 Category: Research Source Type: clinical trials

A phase 2 randomised controlled trial of serelaxin to lower portal pressure in cirrhosis (STOPP)
AbstractBackgroundIn preclinical models, recombinant human relaxin-2 (serelaxin) had anti-fibrotic effects and ameliorated portal hypertension (PH). A small exploratory study in patients with cirrhosis also suggested that serelaxin could reduce portal pressure.MethodsIn a phase 2, double-blind, randomised controlled study conducted in a single centre (Royal Infirmary of Edinburgh, UK), male and female adult participants with cirrhosis and clinically significant PH (CSPH; hepatic venous pressure gradient (HVPG)>  10 mmHg) were enrolled. Participants were allocated to serelaxin or placebo in a 3:1 ratio. The...
Source: Trials - March 12, 2020 Category: Research Source Type: clinical trials

A Cohort Study on Long-term Clinical Outcomes of Antiviral Therapy in Patients With Chronic Hepatitis B and Cirrhosis
Condition:   Chronic Hepatitis b Intervention:   Drug: interferon Sponsor:   Beijing Ditan Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 10, 2020 Category: Research Source Type: clinical trials