Metabolomics in cirrhosis: Recent advances and opportunities
Clin Chim Acta. 2024 Mar 29;557:117886. doi: 10.1016/j.cca.2024.117886. Online ahead of print.ABSTRACTLiver cirrhosis (LC) represents a significant hepatic disorder that persistently commands the attention of the scientific community, especially concerning its pathogenesis and therapeutic approaches. Metabolomics, the comprehensive profiling of an organism's metabolome, has been increasingly applied in the research of cirrhosis over the past decade. This review summarizes the recent advancements and applications of metabolomics within the context of LC research, in recent five years. It highlights the role of metabolomics ...
Source: International Journal of Clinical Chemistry - March 31, 2024 Category: Chemistry Authors: Yan-Qun Luo Cai-Yun Zhang Xia-Zhen Nong Ying Gao Lei Wang Guang Ji Tao Wu Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research
Kinesin family member 12-related hepatopathy: A generally indolent disorder with elevated gamma-glutamyl-transferase activity
Clin Genet. 2024 Mar 29. doi: 10.1111/cge.14524. Online ahead of print.ABSTRACTExome sequencing (ES) has identified biallelic kinesin family member 12 (KIF12) mutations as underlying neonatal cholestatic liver disease. We collected information on onset and progression of this entity. Among consecutively referred pediatric patients at our centers, diagnostic ES identified 4 patients with novel, biallelic KIF12 variants using the human GRCh38 reference sequence, as KIF12 remains incompletely annotated in the older reference sequence GRCh37. A review of these and of 21 reported patients with KIF12 variants found that presenta...
Source: Clinical Genetics - March 30, 2024 Category: Genetics & Stem Cells Authors: Georg-Friedrich Vogel Alexandra Podpeskar Dietmar Rieder Helin Salzer Dorota Garczarczyk-Asim Li Wang Kuerbanjiang Abuduxikuer Jian-She Wang Anke Scharrer Eissa Ali Faqeih Ali T Aseeri Julia Vodopiutz Andreas Heilos Judith Pichler Wolf-Dietrich Huber Thom Source Type: research
Kinesin family member 12-related hepatopathy: A generally indolent disorder with elevated gamma-glutamyl-transferase activity
Clin Genet. 2024 Mar 29. doi: 10.1111/cge.14524. Online ahead of print.ABSTRACTExome sequencing (ES) has identified biallelic kinesin family member 12 (KIF12) mutations as underlying neonatal cholestatic liver disease. We collected information on onset and progression of this entity. Among consecutively referred pediatric patients at our centers, diagnostic ES identified 4 patients with novel, biallelic KIF12 variants using the human GRCh38 reference sequence, as KIF12 remains incompletely annotated in the older reference sequence GRCh37. A review of these and of 21 reported patients with KIF12 variants found that presenta...
Source: Clinical Genetics - March 30, 2024 Category: Genetics & Stem Cells Authors: Georg-Friedrich Vogel Alexandra Podpeskar Dietmar Rieder Helin Salzer Dorota Garczarczyk-Asim Li Wang Kuerbanjiang Abuduxikuer Jian-She Wang Anke Scharrer Eissa Ali Faqeih Ali T Aseeri Julia Vodopiutz Andreas Heilos Judith Pichler Wolf-Dietrich Huber Thom Source Type: research
Kinesin family member 12-related hepatopathy: A generally indolent disorder with elevated gamma-glutamyl-transferase activity
Clin Genet. 2024 Mar 29. doi: 10.1111/cge.14524. Online ahead of print.ABSTRACTExome sequencing (ES) has identified biallelic kinesin family member 12 (KIF12) mutations as underlying neonatal cholestatic liver disease. We collected information on onset and progression of this entity. Among consecutively referred pediatric patients at our centers, diagnostic ES identified 4 patients with novel, biallelic KIF12 variants using the human GRCh38 reference sequence, as KIF12 remains incompletely annotated in the older reference sequence GRCh37. A review of these and of 21 reported patients with KIF12 variants found that presenta...
Source: Clinical Genetics - March 30, 2024 Category: Genetics & Stem Cells Authors: Georg-Friedrich Vogel Alexandra Podpeskar Dietmar Rieder Helin Salzer Dorota Garczarczyk-Asim Li Wang Kuerbanjiang Abuduxikuer Jian-She Wang Anke Scharrer Eissa Ali Faqeih Ali T Aseeri Julia Vodopiutz Andreas Heilos Judith Pichler Wolf-Dietrich Huber Thom Source Type: research
Emerging drugs for the treatment of sarcopenia in cirrhosis of the liver
Expert Opin Emerg Drugs. 2024 Mar 28:1-11. doi: 10.1080/14728214.2024.2332428. Online ahead of print.NO ABSTRACTPMID:38549232 | DOI:10.1080/14728214.2024.2332428 (Source: Expert Opinion on Emerging Drugs)
Source: Expert Opinion on Emerging Drugs - March 29, 2024 Category: Drugs & Pharmacology Authors: Simone Di Cola Saniya Khan Lucia Lapenna Manuela Merli Source Type: research
