Palliative long-term abdominal drains < em > vs < /em > large volume paracenteses for the management of refractory ascites in end-stage liver disease
CONCLUSION: The use of LTAD in the management of refractory ascites in palliated end-stage liver disease is effective, safe, and may reduce hospital admissions and utilisation of healthcare resources compared to LVP.PMID:38577536 | PMC:PMC10989306 | DOI:10.4254/wjh.v16.i3.428 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Senamjit Kaur Rodrigo V Motta Bryony Chapman Victoria Wharton Jane D Collier Francesca Saffioti Source Type: research
Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma
CONCLUSION: Lean patients with cirrhosis and HCC present with larger tumors and are more often outside Milan criteria, reflecting cancer related cachexia from delayed diagnosis. Access to care for hepatitis C virus therapy and liver transplantation confer a survival benefit, but not overweight or obese BMI classifications.PMID:38577534 | PMC:PMC10989303 | DOI:10.4254/wjh.v16.i3.393 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Andrew Scott deLemos Jing Zhao Milin Patel Banks Kooken Karan Mathur Hieu Minh Nguyen Areej Mazhar Maggie McCarter Heather Burney Carla Kettler Naga Chalasani Samer Gawrieh Source Type: research
Outcome of individuals with alcoholic cirrhosis hospitalized with first decompensation and their predictors
CONCLUSIONS: There is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.PMID:38577860 | DOI:10.4103/ijmr.ijmr_1690_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 5, 2024 Category: Biomedical Science Authors: Suprabhat Giri Sushrut Ingawale Sidharth Harindanath Mohit Jain Pranav Garg Harish Darak Sanjay Kumar Aditya Kale Akash Shukla Source Type: research
Safety and preliminary efficacy of pembrolizumab following trans-arterial chemoembolization for hepatocellular carcinoma: the PETAL phase Ib study
CONCLUSIONS: TACE plus pembrolizumab was tolerable with no evidence of synergistic toxicity, encouraging further clinical development of immunotherapy alongside TACE.PMID:38578610 | DOI:10.1158/1078-0432.CCR-24-0177 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: David J Pinato Antonio D'Alessio Claudia Angela Maria Fulgenzi Alexandra Emilia Schlaak Ciro Celsa Saskia Killmer Jesus Miguens Blanco Caroline Ward Charalampos-Vlasios Stikas Mark R Openshaw Nicole Acuti Georgios Nteliopoulos Cristina Balcells Hector C K Source Type: research
Safety and preliminary efficacy of pembrolizumab following trans-arterial chemoembolization for hepatocellular carcinoma: the PETAL phase Ib study
CONCLUSIONS: TACE plus pembrolizumab was tolerable with no evidence of synergistic toxicity, encouraging further clinical development of immunotherapy alongside TACE.PMID:38578610 | DOI:10.1158/1078-0432.CCR-24-0177 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 5, 2024 Category: Cancer & Oncology Authors: David J Pinato Antonio D'Alessio Claudia Angela Maria Fulgenzi Alexandra Emilia Schlaak Ciro Celsa Saskia Killmer Jesus Miguens Blanco Caroline Ward Charalampos-Vlasios Stikas Mark R Openshaw Nicole Acuti Georgios Nteliopoulos Cristina Balcells Hector C K Source Type: research
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
CONCLUSION: Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.PMID:38577193 | PMC:PMC10989495 | DOI:10.3748/wjg.v30.i9.1177 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Song-Man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan Huang Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions
This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ, which is one of the primary routes that MPs/NPs enter human bodies. The interrelated mechanisms including oxidative stress, hepatocyte energy re-distribution, cell death and autophagy, as well as immune responses and inflammation, were also featured. In addition, the disturbance of microbiome and gut-liver axis, and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease, steatohepatitis, liver fibrosis, and cirrhosis were briefly discussed. Finally, we ...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Chun-Cheng Chiang Hsuan Yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen Source Type: research
Role of albumin-bilirubin score in non-malignant liver disease
This article presents a review of the application of ALBI scores in various non-malignant liver diseases.PMID:38577181 | PMC:PMC10989493 | DOI:10.3748/wjg.v30.i9.999 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Shi-Xue Xu Fan Yang Nan Ge Jin-Tao Guo Si-Yu Sun Source Type: research
sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis
CONCLUSION: Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.PMID:38577193 | PMC:PMC10989495 | DOI:10.3748/wjg.v30.i9.1177 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Song-Man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan Huang Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions
This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ, which is one of the primary routes that MPs/NPs enter human bodies. The interrelated mechanisms including oxidative stress, hepatocyte energy re-distribution, cell death and autophagy, as well as immune responses and inflammation, were also featured. In addition, the disturbance of microbiome and gut-liver axis, and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease, steatohepatitis, liver fibrosis, and cirrhosis were briefly discussed. Finally, we ...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Chun-Cheng Chiang Hsuan Yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen Source Type: research
Role of albumin-bilirubin score in non-malignant liver disease
This article presents a review of the application of ALBI scores in various non-malignant liver diseases.PMID:38577181 | PMC:PMC10989493 | DOI:10.3748/wjg.v30.i9.999 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Shi-Xue Xu Fan Yang Nan Ge Jin-Tao Guo Si-Yu Sun Source Type: research
"The Prognostic Role of Aspartate Transaminase to Platelet Ratio Index (APRI) on Outcomes Following Non-emergent Minor Hepatectomy"
CONCLUSIONS: APRI ≥0.7 is associated with perioperative transfusion, overall morbidity, and 30-day mortality. APRI may serve as a noninvasive tool to risk stratify patients prior to elective minor hepatectomy.PMID:38579287 | DOI:10.1177/00031348241244645 (Source: The American Surgeon)
Source: The American Surgeon - April 5, 2024 Category: Surgery Authors: Dhruv J Patel Michael T LeCompte Hong Jin Kim Elizabeth M Gleeson Source Type: research
Outcome of individuals with alcoholic cirrhosis hospitalized with first decompensation and their predictors
CONCLUSIONS: There is significant heterogeneity in the type of decompensation in individuals with alcoholic cirrhosis. We observed significantly high mortality rate among alcoholic participants hospitalized with initial decompensation; deaths occurring in more than one-third of study participants within 90 days.PMID:38577860 | DOI:10.4103/ijmr.ijmr_1690_22 (Source: Indian J Med Res)
Source: Indian J Med Res - April 5, 2024 Category: Research Authors: Suprabhat Giri Sushrut Ingawale Sidharth Harindanath Mohit Jain Pranav Garg Harish Darak Sanjay Kumar Aditya Kale Akash Shukla Source Type: research
