Due to risk of serious liver injury, FDA restricts use of Ocaliva (obeticholic acid) in primary biliary cholangitis (PBC) patients with advanced cirrhosis
; adding and updating warnings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 3, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news
FDA Restricts Obeticholic Acid Over Serious Liver Injury Risk FDA Restricts Obeticholic Acid Over Serious Liver Injury Risk
Obeticholic acid is now contraindicated in patients with primary biliary cholangitis and advanced cirrhosis, following reports of serious liver injury leading to liver decompensation or liver failure.News Alerts (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - May 26, 2021 Category: Gastroenterology Tags: Gastroenterology News Alert Source Type: news
Ocaliva (obeticholic acid) by Intercept Pharmaceuticals: Drug Safety Communication - Due to Risk of Serious Liver Injury, FDA Restricts Use of Ocaliva in Primary Biliary Cholangitis Patients with Advanced Cirrhosis
FDA is restricting the use of the liver disease medicine Ocaliva (obeticholic acid) in patients having primary biliary cholangitis with advanced cirrhosis of the liver because some patients with cirrhosis who took Ocaliva, especially those with evidence of advanced cirrhosis, developed liver failure (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 26, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Due to risk of serious liver injury, FDA restricts use of Ocaliva in primary biliary cholangitis (PBC) patients with advanced cirrhosis
; adding and updating warnings (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 26, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Gut check
(Harvard Medical School) Researchers identify links between genetic makeup of bacteria in human gut and several human diseases. Clusters of bacterial genes present in conditions including cardiovascular illness, inflammatory bowel disease, liver cirrhosis, and cancer. Work brings scientist closer to developing tests that could predict disease risk or identify disease presence based on a sampling of the genetic makeup of a person's microbiome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2021 Category: International Medicine & Public Health Source Type: news
Suvorexant poisoning in a patient with cirrhosis and renal failure - Ito H, Ogawa Y, Shimojo N, Kawano S.
Suvorexant is a novel hypnotic that acts as an orexin-1 receptor and orexin-2 receptor antagonist. Owing to its safety and tolerability, suvorexant has recently become widely used. However, little is known about the presentation of suvorexant poisoning. He... (Source: SafetyLit)
Source: SafetyLit - May 12, 2021 Category: International Medicine & Public Health Tags: Poisoning Source Type: news
Fatty liver disease: The texture of your faeces could signal organ damage
FATTY liver disease progresses through four stages: steatosis, steatohepatitis, fibrosis, and cirrhosis. Most people are unlikely to experience symptoms until the liver is struggling to function. (Source: Daily Express - Health)
Source: Daily Express - Health - May 9, 2021 Category: Consumer Health News Source Type: news
Bariatric Surgery and Alcohol-Related Cirrhosis/Alcohol Misuse Bariatric Surgery and Alcohol-Related Cirrhosis/Alcohol Misuse
Does bariatric surgery impact the subsequent risk of alcohol misuse and alcohol-related cirrhosis?Liver International (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - May 7, 2021 Category: Surgery Tags: Gastroenterology Journal Article Source Type: news
Fatty liver disease symptoms: The key physical indication your organ is damaged
EXCESS fat stored in the liver can result in organ damage, which can reduce its capability to perform multiple life-supporting functions. Scarring of the liver, known as cirrhosis, may lead to symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - April 30, 2021 Category: Consumer Health News Source Type: news
Portopulmonary hypertension in patients with chronic liver disease
(Shinshu University) Portopulmonary hypertension (PoPH) is a form of pulmonary arterial hypertension (PAH). PoPH occurs in approximately 15% of patients with PAH, and is reportedly found in 2-6% of patients with portal hypertension and 1-2% of patients with liver cirrhosis according to studies from Europe and America. However, the real-world data on PoPH in Japan are largely unknown, with many questions on the condition's etiology and prevalence. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2021 Category: International Medicine & Public Health Source Type: news
Falls are common, morbid, and predictable in patients with cirrhosis - Tapper EB, Nikirk S, Parikh N, Zhao L.
BACKGROUND: Falls are a devastating complication of cirrhosis. The risk of falls in contemporary patients without HE is unclear. Further, bedside tools for predicting falls are lacking METHODS: We prospectively enrolled 299 subjects with currently compensa... (Source: SafetyLit)
Source: SafetyLit - April 26, 2021 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
The efficacy of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: a protocol for systematic review and meta-analysis - Wang N, Yao W, Ma R, Ren F.
OBJECTIVE: The effect of probiotics on cognitive function and the risk of falling in cirrhosis patients have not been previously evaluated. We perform this protocol for systematic review and meta-analysis to evaluate the effect of a multistrain probiotic o... (Source: SafetyLit)
Source: SafetyLit - April 23, 2021 Category: International Medicine & Public Health Tags: Falls Source Type: news
Non-alcoholic fatty liver disease symptoms: Three symptoms that signal 'permanent' damage
NON-ALCOHOLIC fatty liver disease often goes undetected until it progresses to cirrhosis. What is cirrhosis and what are the symptoms to expect? (Source: Daily Express - Health)
Source: Daily Express - Health - April 13, 2021 Category: Consumer Health News Source Type: news
Genetic Risk Factors for Cirrhosis in Hemochromatosis Genetic Risk Factors for Cirrhosis in Hemochromatosis
This study identified gene variants which modulate the cirrhosis risk in hereditary hemochromatosis.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Primary Biliary Cirrhosis (PBC) Treatment
Title: Primary Biliary Cirrhosis (PBC) TreatmentCategory: Diseases and ConditionsCreated: 8/21/2001 12:00:00 AMLast Editorial Review: 3/29/2021 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - March 29, 2021 Category: Nutrition Source Type: news
