TGen-led study shows DNA methylation related to liver disease among obese patients
(The Translational Genomics Research Institute) A TGen-led team has identified how DNA methylation is associated with a condition known as non-alcoholic fatty liver disease (NAFLD), which can lead to liver cirrhosis and death, and is one of the leading indicators for liver transplants. In one of the most exacting studies of its kind, TGen scientists found evidence that DNA methylation has a role in the initiation of NAFLD-related fibrosis, according to a study published in the journal Clinical Epigenetics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2018 Category: International Medicine & Public Health Source Type: news

Liver Cancer Death Rate In US Surged 43% In 16 Years
(CNN) — Death rates from liver cancer increased 43% for American adults from 2000 to 2016, according to a report released Tuesday by the US Centers for Disease Control and Prevention’s National Center for Health Statistics. The increase comes even as mortality for all cancers combined has declined. Liver cancer death rates increased for both men and women 25 and older, as well as white, black and Hispanic people. Only Asians and Pacific Islanders saw a decrease in mortality from liver cancer. The rise in mortality doesn’t mean that liver cancer is deadlier than before, according to Dr. Jiaquan Xu, the aut...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - July 17, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Cancer Liver Cancer Source Type: news

Alcoholic liver disease: Take this many hours off drinking a week to slash your risk
ALCOHOLIC liver disease is a problem caused by drinking too much alcohol, but symptoms usually only show when the organ has been severely damaged. It ’s important to recognise these signs as repeated damage can lead to cirrhosis - permanent scarring of the liver. One way to avoid the condition developing in the first place is to avoid drinking regularly. You should also have a certain time off drinking a week to allow your liver to recover. (Source: Daily Express - Health)
Source: Daily Express - Health - July 4, 2018 Category: Consumer Health News Source Type: news

Liver damage: Drinking this much alcohol a day can lead to organ failure
LIVER damage, or liver disease as it ’s also referred, is commonly caused by obesity, an undiagnosed hepatitis infection and alcohol misuse. Drinking too much alcohol can lead to a condition called alcohol-relate cirrhosis and serious complications can occur. But what counts as excessive drinking and what’s the recommended number o f units of alcohol that should be consumed in a day? (Source: Daily Express - Health)
Source: Daily Express - Health - July 2, 2018 Category: Consumer Health News Source Type: news

A flavonoid in fruits and vegetables found to prevent hepatitis B
(Natural News) Naringenin is a dietary flavonoid present in many fruits, herbs, and vegetables. Taiwanese researchers believe this phytochemical can stop the hepatitis B virus (HBV) from causing hepatitis, liver cirrhosis, and liver cancer. The virus spreads by infecting the host DNA with the HBV X protein (HBx). Even as the liver heals following every instance of... (Source: NaturalNews.com)
Source: NaturalNews.com - June 29, 2018 Category: Consumer Health News Source Type: news

Liver disease symptoms: Two toilet habits that could indicate you have severe organ damage
LIVER disease symptoms, caused by excessive alcohol intake, usually only show when the organ has been severely damaged. Cirrhosis is the name given to scarring of the liver caused by long-term liver damage. There are two signs linked to your toilet habits that can indicate this. (Source: Daily Express - Health)
Source: Daily Express - Health - June 28, 2018 Category: Consumer Health News Source Type: news

Follow-up of Patients With HCV, Liver Disease After DAAs Follow-up of Patients With HCV, Liver Disease After DAAs
This study evaluated the long-term success of viral eradication in patients with advanced fibrosis or cirrhosis treated with DAAs.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 28, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Liver disease symptoms: Seven signs your organ has been severely damaged by alcohol
LIVER disease symptoms, caused by excessive alcohol intake, usually only show when the organ has been severely damaged. It ’s important to recognise these signs as repeated damage can lead to alcoholic liver cirrhosis. There are seven symptoms to look out for. (Source: Daily Express - Health)
Source: Daily Express - Health - June 19, 2018 Category: Consumer Health News Source Type: news

Researchers find a promising new approach for treating liver cirrhosis
(Elsevier) In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 18, 2018 Category: International Medicine & Public Health Source Type: news

Chronic Viral Hepatitis, Alcoholism, Cirrhosis Linked to Liver Cancer
Title: Chronic Viral Hepatitis, Alcoholism, Cirrhosis Linked to Liver CancerCategory: Doctor's& Expert's views on SymptomsCreated: 10/31/2001 12:00:00 AMLast Editorial Review: 6/13/2018 2:55:10 PM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - June 13, 2018 Category: Cancer & Oncology Source Type: news

Liver Cancer Screening in At-Risk Patients Underused (CME/CE)
(MedPage Today) -- Cirrhosis patients, others not getting tested, study finds (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - June 6, 2018 Category: Hematology Source Type: news

Eating a Mediterranean-style diet protects your liver
(Natural News) If you want a healthy liver and gut, an article on EurekAlert! recommended taking up a Mediterranean-style diet. A study on American and Turkish patients with liver cirrhosis showed that eating fermented milk products and vegetables – plus moderate amounts of chocolate, coffee, and tea – could reduce the chances of serious complications that... (Source: NaturalNews.com)
Source: NaturalNews.com - May 10, 2018 Category: Consumer Health News Source Type: news

Shocking video reveals how alcohol wrecks your liver
Celebrity doctor Drew Pinsky, who hosts the show Dr Drew's Lifechangers in the US, tells two heavy-drinking twins how alcohol could give them cirrhosis and one day kill them. (Source: the Mail online | Health)
Source: the Mail online | Health - May 9, 2018 Category: Consumer Health News Source Type: news

Study: Alcohol-related cirrhosis patients are sicker, costlier and often female
(Michigan Medicine - University of Michigan) A new review by Michigan Medicine finds that women drinkers are disproportionately affected in alcohol-related cirrhosis cases. Why -- and what's next. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 7, 2018 Category: International Medicine & Public Health Source Type: news

CBCT-guided radiotherapy shows promise for HCC
A novel radiotherapy technique using conebeam CT (CBCT) shows promise as a...Read more on AuntMinnie.comRelated Reading: Adding blood test to US improves liver cancer diagnosis Contrast US clears up indeterminate HCC cases on MRI US surveillance of HCC subject to image quality issues HCC screening boosts survival rate in cirrhosis patients Dual-tracer PET/CT helps pick patients for liver transplant (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - April 24, 2018 Category: Radiology Source Type: news

What Causes Hyponatremia?
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - April 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Unlocking the Potential of AI For Fatty Liver Treatments
ReviveMed, a Massachusetts Institute of Technology (MIT) spinout, is using artificial intelligence (AI) to unlock the power of metabolomics to discover new therapies to treat diseases. Metabolomics is the large-scale study of small molecules like glucose or cholesterol produced by cellular activity. ReviveMed’s platform could help pharmaceutical companies redesign existing drugs or develop new drugs to help patients suffering from disease. The Cambridge, MA-based company recently raised funding to help further develop its AI solution, closing an oversubscribed seed round of $1.5 million. Rivas Capital led the round, ...
Source: MDDI - April 20, 2018 Category: Medical Devices Authors: Omar Ford Tags: Software Source Type: news

OBV/PTV/r+DSV+RBV in Patients With HCV Cirrhosis OBV/PTV/r+DSV+RBV in Patients With HCV Cirrhosis
Does real-life data confirm the results of clinical trials regarding the efficacy and safety profile of this DAA regimen in patients with HCV infection and cirrhosis?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Liver Transplant in Patients With Alcoholic Liver Disease Liver Transplant in Patients With Alcoholic Liver Disease
Some transplant centers are reluctant to perform liver transplants in patients with alcoholic liver disease. Do these patients have worse outcomes than those transplanted for viral cirrhosis?Alcohol and Alcoholism (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2018 Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news

Costs Balloon after Cirrhosis Diagnosis for NAFLD/NASH (CME/CE)
(MedPage Today) -- Experts say study emphasizes importance of identifying patients early (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 16, 2018 Category: Primary Care Source Type: news

A Mediterranean diet may boost the health of the liver
Adopting the diet, loaded with fruit and veg, whole grains, olive oil and fish, lowers the risk of hospitalisation in patients with cirrhosis, experts at Virginia Commonwealth University found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2018 Category: Consumer Health News Source Type: news

Difficult-to-Treat Sclerosing Cholangitis Eased With Statins Difficult-to-Treat Sclerosing Cholangitis Eased With Statins
Primary sclerosing cholangitis is progressive, and there is no known therapy to prevent cirrhosis, liver transplant, or progression to cancer, but a new investigation suggests statins might help.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 13, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Germany: compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
(European Association for the Study of the Liver) Compensated cirrhosis substantially increases comorbidities and healthcare costs for patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

Long-term obeticholic acid treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with PBC
(European Association for the Study of the Liver) After three years of treatment with obeticholic acid, 85 percent of patients with PBC and an incomplete response to UDCA experienced stabilization or regression of fibrosis/cirrhosis in the POISE biopsy sub-study. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2018 Category: International Medicine & Public Health Source Type: news

' Alarming' New Numbers on Bacterial Infection in Cirrhosis'Alarming' New Numbers on Bacterial Infection in Cirrhosis
One-third of infections in cirrhotic patients around the world are caused by multidrug-resistant organisms, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 12, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Many Cirrhosis Patients Harbor Multidrug-Resistant Bugs (CME/CE)
(MedPage Today) -- 18% of North Americans with infections; three-quarters of those in India (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 12, 2018 Category: American Health Source Type: news

Non-profit ’s $300 hepatitis C cure as effective as $84,000 alternative
Exclusive: 71 million people stand to benefit from reduced price treatment for virus which can lead to liver cirrhosis, cancer and deathAn affordable hepatitis C treatment has been shown to be safe and effective, with very high cure rates for patients including hard-to-treat cases, in interim clinical trial results that offer hope to the 71 million people living with the disease worldwide. The treatment is expected to cost $300 for 12 weeks, or $3.50 per day, in Malaysia, where trials were conducted along with Thailand – a fraction of the cost of other hepatitis C medicines produced by major drugmakers, which often r...
Source: Guardian Unlimited Science - April 12, 2018 Category: Science Authors: Julia Kollewe Tags: Medical research Hepatitis C Global health Global development Science Society Egypt Pharmaceuticals industry Source Type: news

Sensitive new assay detects hepatitis B infection in single liver cells and serum
(Elsevier) Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study published in The Journal of Molecular Diagnostics describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples. This assay can be used to diagnose HCC at an earlier stage to manage treatment more effectively. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 12, 2018 Category: International Medicine & Public Health Source Type: news

A third of bacterial infections in patients with cirrhosis across the world are multi-drug resistant
(European Association for the Study of the Liver) An international study reports a high prevalence of multi-drug-resistant bacteria in hospitalized patients with cirrhosis and significant regional differences in risk. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 12, 2018 Category: Biology Source Type: news

Mediterranean-style diet improves gut microbial diversity and reduces hospitalization
(European Association for the Study of the Liver) ILC 2018: Diets rich in vegetables, fermented milk products, tea, coffee and chocolate may improve outcomes in patients with liver cirrhosis. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 12, 2018 Category: Biology Source Type: news

Screening for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis achieving sustained virological response is likely to be cost effective
(European Association for the Study of the Liver) A Canadian study suggests that biannual or annual ultrasound screening for HCC is likely to be cost effective after a sustained virological response in those with hepatitis C-related cirrhosis, but not in those with advanced fibrosis without cirrhosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2018 Category: Cancer & Oncology Source Type: news

Scotland: Direct-acting antiviral agent therapy reduces the burden of HCV-related decompensated cirrhosis
(European Association for the Study of the Liver) National surveillance data and cost-effectiveness modeling provide complementary evidence to support the scale-up of DAA therapy in Scotland. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 12, 2018 Category: Infectious Diseases Source Type: news

Punjab, India: Mass treatment of a population with chronic hepatitis C infection produces high rates of cure
(European Association for the Study of the Liver) A program of decentralized public healthcare achieves high rates of cure regardless of genotype or the presence of cirrhosis: the Punjab Model. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 12, 2018 Category: Infectious Diseases Source Type: news

Exercise to Prevent Cirrhosis in Overweight and Obese Adults Exercise to Prevent Cirrhosis in Overweight and Obese Adults
Learn more about the preventive role of exercise against the development of cirrhosis among overweight or obese adults.Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Cirrhosis of the liver symptoms: Four signs of long-term damage to the vital organ
CIRRHOSIS of the liver symptoms can be confused for those of less serious health conditions. The condition is scarring caused by long-term liver damage, and scar tissue then prevents the liver working properly. So what are the signs to look out for and is there a way of presenting it happening? (Source: Daily Express - Health)
Source: Daily Express - Health - April 4, 2018 Category: Consumer Health News Source Type: news

IFN-free Chronic HCV Therapy With DAAs and Risk for HCC IFN-free Chronic HCV Therapy With DAAs and Risk for HCC
Does IFN-free therapy with direct-acting antivirals alter the short-term risk for hepatocellular carcinoma in patients with cirrhosis?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Periodontitis in Patients With Cirrhosis Periodontitis in Patients With Cirrhosis
This study examined the prevalence and predictors of periodontitis in patients with cirrhosis. How is periodontitis related to nutritional and systemic inflammation status in these patients?BMC Oral Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 30, 2018 Category: Consumer Health News Tags: Dental & Oral Health Journal Article Source Type: news

Gut microbes could help better predict risk of hospitalization for patients with cirrhosis
(Virginia Commonwealth University) The gut microbiome -- a collection of bacteria and other microbes in the gut -- could be a highly accurate predictor of hospitalizations for patients with cirrhosis, according to a recently published study led by a researcher at Virginia Commonwealth University. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2018 Category: International Medicine & Public Health Source Type: news

Obesity, T2DM: Risk Factors Underlying Undiagnosed Cirrhosis Obesity, T2DM: Risk Factors Underlying Undiagnosed Cirrhosis
This study used transient elastography to screen for cirrhosis in a primary care setting.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 29, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Sofosbuvir/Velpatasvir in HCV With Cirrhosis or Fibrosis Sofosbuvir/Velpatasvir in HCV With Cirrhosis or Fibrosis
Is the combination of sofosbuvir and velpastavir a safe and effective therapeutic option for patients with HCV and advanced fibrosis or cirrhosis?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 29, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Twin saved by liver transplant, but it was too late for his brother
Devin and Nick Coats, 18, of Slidell, Louisiana, were diagnosed with stage 4 cirrhosis of the liver in March 2017. However, only one of them received a transplant while the other twin died. (Source: the Mail online | Health)
Source: the Mail online | Health - March 21, 2018 Category: Consumer Health News Source Type: news

Teenage twins needed liver transplants. One of them lived long enough to get his.
Eighteen-year-old Devin Coats was fighting for a second chance to live. His brother, Nicholas, was waiting to die. The identical twin brothers had both been diagnosed last year with Stage 4 cirrhosis of the liver — severe scarring commonly associated with alcoholism. In this case, it was the result of a gene mutation, and both […]Related:Former FDA commissioners say right-to-try bills could endanger ‘vulnerable patients’Top candidate to lead CDC is an HIV/AIDS researcher5 interesting findings about U.S. abortions from a new report on the current science (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - March 21, 2018 Category: Consumer Health News Source Type: news

WATCH: Twins suffering from liver disease, transplant saves one but other dies
Devin and Nick Coats were both diagnosed with stage 4 cirrhosis of the liver. (Source: ABC News: Health)
Source: ABC News: Health - March 21, 2018 Category: Consumer Health News Tags: Health Source Type: news

Oral Oxycodone/Naloxone for Pain Control in Cirrhosis Oral Oxycodone/Naloxone for Pain Control in Cirrhosis
Management of moderate-to-severe pain in patients with cirrhosis and HCC is challenging due to the high risk of serious adverse effects. Can an oral combination of oxycodone/naloxone be used safely?Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 8, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

OBV/PTV/r + Sofosbuvir With or Without RBV for HCV Gt2 or 3 OBV/PTV/r + Sofosbuvir With or Without RBV for HCV Gt2 or 3
This study investigated the efficacy and safety of 12-week OBV/PTV/r + SOF with or without RBV in patients with HCV genotype 2 or 3 infection, including those with cirrhosis.Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 6, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Increased morbidity and mortality associated with falls among patients with cirrhosis - Ezaz G, Murphy SL, Mellinger J, Tapper EB.
BACKGROUND: Injuries are more morbid and complicated to manage in patients with cirrhosis. However, data are limited regarding the relative risk of injury and severity of injury from falls in patients with cirrhosis compared to those without cirrhosis. ... (Source: SafetyLit)
Source: SafetyLit - February 19, 2018 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Adding blood test to US improves liver cancer diagnosis
Performing a blood test in addition to an ultrasound exam improved the sensitivity...Read more on AuntMinnie.comRelated Reading: Lancet: Cancer survival rates improve but vary widely US elastography for liver evaluation: Worth the cost? JAMA: Cancer deaths fall 20% in U.S. since 1980 Cancer mortality continues to drop in U.S. HCC screening boosts survival rate in cirrhosis patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 12, 2018 Category: Radiology Source Type: news

HBV Reactivation in Patients With HCV/HBV Cirrhosis on DAAs HBV Reactivation in Patients With HCV/HBV Cirrhosis on DAAs
Does clearance or suppression of HCV by direct-acting antivirals in patients with chronic HCV hepatitis and HBV coinfection increase the risk of HBV reactivation?Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Cirrhosis Overview Video Cirrhosis Overview Video
This video discusses the pathophysiology of a cirrhotic liver as well as major complications and clinical signs and symptoms of cirrhosis.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 26, 2018 Category: Consumer Health News Tags: Med Students Commentary Source Type: news