FDA approves Vosevi for Hepatitis C
The U.S. Food and Drug Administration today approved Vosevi to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis. (Source: Food and Drug Administration)
Source: Food and Drug Administration - July 18, 2017 Category: American Health Source Type: news

Liver damage and alcohol: How do you know if you have symptomless cirrhosis?
CIRRHOSIS - is long-term liver damage that can eventually lead to liver failure and even increase the risk of cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - July 13, 2017 Category: Consumer Health News Source Type: news

The Link Between Cirrhosis and Stroke: New Findings The Link Between Cirrhosis and Stroke: New Findings
Stroke incidence in patients with cirrhosis was double that of those without cirrhosis. Several factors probably explain why.Medscape Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 12, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery Viewpoint Source Type: news

DAAs for Chronic HCV in a Population Aged 65 Years and Older DAAs for Chronic HCV in a Population Aged 65 Years and Older
Are direct-acting antivirals safe and effective in elderly patients with HCV-related advanced fibrosis or cirrhosis?Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 12, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Hepatitis B jab to be added to immunisations of babies born in UK
Babies born from the 1 August will be offered new “hexavalent” jab in effort to clamp down on infections that cause cirrhosis and liver cancerAll babies born in the UK will receive the hepatitis B jab as part of their routine immunisations from the autumn in an effort to drive down viral infections that cause cirrhosis and liver cancer.The hepatitis B vaccine is to be added to the 5-in-1 jab that is already given to babies across the UK to protect them from diphtheria, tetanus, whooping cough, polio and bacterial infections known as Hib, or haemophilus influenzae type b, health officials said.Continue reading.....
Source: Guardian Unlimited Science - July 9, 2017 Category: Science Authors: Ian Sample Science editor Tags: Hepatitis B Science Society Children UK news Source Type: news

Statins May Curb Progression of Chronic Liver Disease Statins May Curb Progression of Chronic Liver Disease
Statins may slow the progression of hepatic fibrosis, prevent cirrhosis-related hepatic decompensation and reduce all-cause mortality in patients with chronic liver disease - but the evidence is low, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 26, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Relatives of people with fatty liver cirrhosis also at risk
(Reuters Health) - If a parent or sibling has cirrhosis due to non-alcoholic fatty liver disease, a person's odds of having liver scarring are more than 12 times higher than for people without close relatives who have this condition, a small study finds. (Source: Reuters: Health)
Source: Reuters: Health - June 23, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Case Report: Hyperammonemia to Be Considered in Cirrhosis Setting
Authors describe case of 58 - year - old man who received blood obtained 17, 20 days earlier (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 14, 2017 Category: Cancer & Oncology Tags: Family Medicine, Geriatrics, Gastroenterology, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Oncology, Pathology, Journal, Source Type: news

Antiviral therapy is effective in fighting hepatitis C | Letters
The Cochrane analysis casting doubt on this life-saving therapy is flawed and may deter patients from seeking it, say clinicians and scientistsWe are clinicians and scientists who have studied and treated patients with chronic hepatitis C virus infection over many years and patient groups that represent those affected by hepatitis C. We write in response to your article on the effectiveness of antiviral therapy (Hepatitis ‘wonder drug’ may be clinically ineffective, say experts, 9 June). The Cochrane review that you highlight analysed clinical trials, which are by nature short term, where the sole purpose was t...
Source: Guardian Unlimited Science - June 13, 2017 Category: Science Authors: Letters Tags: Hepatitis C Health Pharmaceuticals industry Medical research Drugs Business Science UK news Society Source Type: news

Cirrhosis Tied to Increased Stroke Risk (CME/CE)
(MedPage Today) -- Strongest association seen with subarachnoid and intracerebral hemorrhage (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 6, 2017 Category: Gastroenterology Source Type: news

Liver disease: Deadly form of the condition can also increase risk of stroke
LIVER damage can cause cirrhosis where the liver stops functioning properly. (Source: Daily Express - Health)
Source: Daily Express - Health - June 6, 2017 Category: Consumer Health News Source Type: news

Take a coffee or tea break to protect your liver
Chronic liver diseases rank as the 12th cause of death worldwide and many of these disorders are associated with unhealthy lifestyles. Conversely, a healthier lifestyle can help prevent or reverse liver disease. Liver-related mortality is closely related to the development of cirrhosis, the final consequence of progressive fibrosis, i.e. scarring of the liver resulting from chronic inflammation. According to a new study published in the Journal of Hepatology, researchers found that drinking coffee and herbal tea may protect against liver fibrosis, estimated as the degree of liver stiffness, which is high in extensive scarr...
Source: World Pharma News - June 6, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Cirrhosis Could Raise Stroke Risk
Title: Cirrhosis Could Raise Stroke RiskCategory: Health NewsCreated: 6/5/2017 12:00:00 AMLast Editorial Review: 6/6/2017 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - June 6, 2017 Category: Cardiology Source Type: news

Cirrhosis Tied to Stroke Risk (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Cirrhosis is associated with increased risk for stroke in older adults, according to a JAMA … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 6, 2017 Category: Primary Care Source Type: news

Study: Cirrhosis may increase risk for stroke
Cirrhosis -- a stiffening of liver tissue often tied to excessive drinking of alcohol -- may also raise an older person's odds for a stroke, a new study says. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 5, 2017 Category: Consumer Health News Source Type: news

Cirrhosis Could Raise Stroke Risk
Average yearly rate of the attacks doubled in people with the liver disease, study found Source: HealthDay Related MedlinePlus Pages: Cirrhosis, Stroke (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - June 5, 2017 Category: Consumer Health News Source Type: news

Cirrhosis Could Raise Stroke Risk
MONDAY, June 5, 2017 -- Cirrhosis -- a stiffening of liver tissue that's often tied to excessive drinking of alcohol -- may also raise an older person's odds for a stroke, a new study suggests. " In a nationally representative sample of elderly... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 5, 2017 Category: General Medicine Source Type: news

Ocera doses first patient in Phase IIa trial of OCR-002 to treat cirrhosis
Ocera Therapeutics has started dosing patients in the Phase IIa part of its Phase I/IIa clinical trial of oral OCR-002 (ornithine phenylacetate) for the treatment of cirrhosis. (Source: Drug Development Technology)
Source: Drug Development Technology - June 5, 2017 Category: Pharmaceuticals Source Type: news

Rwanda: Why Children Should Never Take Alcohol
[New Times] It was shocking to see a young boy, merely 16 years having deranged liver function. On examination and with investigations, he was found to have liver cirrhosis. The underlying cause for liver cirrhosis being alcohol, which he had consumed since five of age. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 29, 2017 Category: African Health Source Type: news

World's leading liver experts focus on continuing advancements in liver disease & transplantation
(Intermountain Medical Center) As the prevalence of liver disease continues to rise across the world, the growing number of people impacted by cirrhosis, liver cancer, and nonalcoholic fatty liver disease, is the focus of more than 1,700 of the world's leading liver disease experts. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 24, 2017 Category: Infectious Diseases Source Type: news

Intestinal fungi linked to worsening of alcoholic liver disease
Liver cirrhosis is the 12th leading cause of mortality worldwide, with approximately half of those deaths due to alcohol misuse. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - May 22, 2017 Category: American Health Source Type: news

Media Advisory: Intestinal fungi linked to worsening of alcoholic liver disease
 What A new study funded by the National Institute on Alcohol Abuse and Alcoholism is among the first to suggest that intestinal fungi may contribute to the development of alcoholic liver disease (ALD). ALD encompasses a broad range of liver diseases, from simple steatosis (fatty liver) to end-stage liver disease, or cirrhosis (liver cell death). Liver cirrhosis is the 12th leading cause of mortality worldwide, with approximately half of those deaths due to alcohol misuse.   (Source: NIAAA News)
Source: NIAAA News - May 22, 2017 Category: Addiction Authors: groa Source Type: news

Intestinal fungi worsen alcoholic liver disease
(University of California - San Diego) Liver cirrhosis is the 12th leading cause of mortality worldwide and approximately half of those deaths are due to alcohol abuse. Yet apart from alcohol abstinence, there are no specific treatments to reduce the severity of alcohol-associated liver disease. Researchers at University of California San Diego School of Medicine and J. Craig Venter Institute (JCVI) have linked intestinal fungi to increased risk of death for patients with alcohol-related liver disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 22, 2017 Category: International Medicine & Public Health Source Type: news

Primary biliary cirrhosis
(Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - May 16, 2017 Category: Consumer Health News Source Type: news

New pill spares women trauma of liver transplant
In the UK, 20,000 people – 90 per cent of them women – suffer from primary biliary cholangitis, also known as primary biliary cirrhosis (PBC). (Source: the Mail online | Health)
Source: the Mail online | Health - May 13, 2017 Category: Consumer Health News Source Type: news

Gene Variant Predicts Liver Recovery After HCV Cure (CME/CE)
(MedPage Today) -- Finding might help treatment options in decompensated cirrhosis (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - May 8, 2017 Category: Gastroenterology Source Type: news

Gene Variation Predicts Recovery in Decompensated Hep C Gene Variation Predicts Recovery in Decompensated Hep C
Genetic differences that are associated with recovery in patients with hepatitis C and decompensated cirrhosis who achieve a sustained virologic response could someday guide liver transplantation.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 7, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Study: Genetic markers may predict which HCV, cirrhosis patients improve with treatment
This study was presented at Digestive Disease Week ® (DDW) 2017, the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 6, 2017 Category: Global & Universal Source Type: news

Stool microbes predict advanced liver disease
Nonalcoholic fatty liver disease (NAFLD) -- a condition that can lead to liver cirrhosis and cancer -- isn't typically detected until well advanced. Even then, diagnosis requires a biopsy. To more easily detect NAFLD, researchers report that the microbial makeup of a patient's stool -- gut microbiome -- can be used to predict advanced NAFLD with 88 to 94 percent accuracy. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 2, 2017 Category: Science Source Type: news

Managing Upper GI Bleeding Due to Portal Hypertension Managing Upper GI Bleeding Due to Portal Hypertension
Dr Rowan Zetterman examines new practice guidance for the diagnosis and management of patients with cirrhosis and portal hypertension.Medscape Gastroenterology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - April 27, 2017 Category: Gastroenterology Tags: Gastroenterology Expert Column Source Type: news

New System Detects Cirrhosis in Fatty Liver Disease New System Detects Cirrhosis in Fatty Liver Disease
With up to 40% of patients in primary care in the US and Europe affected by fatty liver disease, identifying who will develop fibrosis or cirrhosis is a challenge, but a new strategy appears to help.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 26, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Long-Term Albumin Tx Ups Survival in Liver Failure (CME/CE)
(MedPage Today) -- Patients with decompensated cirrhosis also report better quality of life (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 25, 2017 Category: Gastroenterology Source Type: news

Sofosbuvir Plus an NS5A Inhibitor for HCV GT3 and Cirrhosis Sofosbuvir Plus an NS5A Inhibitor for HCV GT3 and Cirrhosis
This study evaluated the efficacy of regimens of SOF plus an NS5A inhibitor with or without RBV in this group.Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 25, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Albumin Improves Survival in Decompensated Cirrhosis Albumin Improves Survival in Decompensated Cirrhosis
A new study answers an old question by showing that adjunctive albumin improves survival and reduces complications in patients with decompensated cirrhosis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 24, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Climate Tied to Alcohol-Related Liver Disease
(MedPage Today) -- Is alcoholic cirrhosis a product of cold, gray weather? (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 24, 2017 Category: Gastroenterology Source Type: news

How Common is α -1-Antitrypsin Deficiency?
Discussion α-1-Antitrypsin Deficiency (A1AT) is a common single-gene mutation disease that is homozygous recessive. The normal allele is called M and the most common abnormal allele is Z. There are other alleles though. The gene codes for one of the primary protease inhibitors in the serum, thus those who are homozygous for the Z gene are sometimes referred to as “PIZZ” or “PIZ.” α-1-Antitrypsin is found in all body tissues but is especially important in the serum and lung. As noted it is one of the primary neutrophil protease inhibitors in the serum, and acts to neutralize these enzymes...
Source: PediatricEducation.org - April 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Cold weather, fewer sun hours are associated with increased rates of alcoholic cirrhosis
Colder and less sunny regions of the world have higher rates of alcoholic cirrhosis, a disease caused by excessive drinking which results in irreversible scarring of the liver, new research shows. An international team of scientists found that every increase in temperature of one degree Celsius was linked with a decrease in the alcohol-attributable fraction of cirrhosis of 0.3 percent. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 23, 2017 Category: Science Source Type: news

HCV Treatment Can Avert Transplant Even in Severe Disease
(MedPage Today) -- A quarter of patients with decompensated cirrhosis could safely get off waiting list (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 22, 2017 Category: Gastroenterology Source Type: news

Long-term treatment of decompensated cirrhosis with human albumin improves survival
(European Association for the Study of the Liver) Results from the ANSWER study showed that long-term administration of human albumin improves the survival rate of patients with decompensated cirrhosis. The study, presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, demonstrated that treatment with human albumin also improved the management of ascites (accumulation of fluid in the abdominal cavity) and quality of life, and reduced the incidence of severe complications of the disease and the need for hospitalization. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 22, 2017 Category: Global & Universal Source Type: news

Cold weather & fewer sun hours are associated with increased rates of alcoholic cirrhosis
(European Association for the Study of the Liver) New data presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, suggests that colder and less sunny regions of the world have higher rates of alcoholic cirrhosis, a disease caused by excessive drinking which results in irreversible scarring of the liver. An international team of scientists found that every increase in temperature of one degree Celsius was linked with a decrease in the alcohol-attributable fraction of cirrhosis of 0.3 percent. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 22, 2017 Category: Global & Universal Source Type: news

Eight Weeks of Treatment with AbbVie's Investigational, Pan-Genotypic Regimen of Glecaprevir/Pibrentasvir (G/P) Achieved High SVR(12) Rates in Challenging to Treat Genotype 3 Chronic Hepatitis C
95 percent of patients infected with genotype 3 (GT3) chronic hepatitis C virus (HCV), without cirrhosis and who are new to treatment, achieved SVR(12) with 8 weeks of treatment(1) Together with previously reported data, these study results support the ... Biopharmaceuticals AbbVie, glecaprevir, pibrentasvir, hepatitis C, ENDURANCE-3 (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 21, 2017 Category: Pharmaceuticals Source Type: news

Antibiotic Cuts Death Risk in Severe Cirrhosis (CME/CE)
(MedPage Today) -- Analysis also shows reduced rate of infection (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 20, 2017 Category: Gastroenterology Source Type: news

New Hep C Combo Cures Most Patients with Cirrhosis (CME/CE)
(MedPage Today) -- Glecaprevir/pibrentasvir highly effective against most hepatitis C genotypes (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 20, 2017 Category: Gastroenterology Source Type: news

Gum Disease, Mortality Linked in Cirrhosis
(MedPage Today) -- Severity of periodontitis increases risk (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 20, 2017 Category: Gastroenterology Source Type: news

Investigational DAA treatment combination effective and improves patient-reported outcomes
(European Association for the Study of the Liver) Analysis of patient outcome data from the POLARIS-1, 2, 3 and 4 studies demonstrate that patients with HCV and cirrhosis have greatest improvements of PRO scores when taking treatment with sofosbuvir + velpatasvir, ± voxilaprevir, an anti-HCV regimen that has been shown to be safe and effective against all HCV genotypes. The analysis, presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, showed that achievement of SVR12 was associated with improvements in PROs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 20, 2017 Category: Infectious Diseases Source Type: news

Long-term antibiotic prophylaxis reduces mortality in people with advanced liver disease
(European Association for the Study of the Liver) A multicenter, randomized, controlled study presented today found that long-term oral antibiotic therapy with norfloxacin improved the prognosis of people with life-threatening advanced liver disease. The study, presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands, showed that norfloxacin administration for six months was associated with a reduced risk of death and infection at six months in patients with Child-Pugh class C cirrhosis, a very severe and advanced stage of liver disease. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 20, 2017 Category: Infectious Diseases Source Type: news

Severe gum disease strongly predicts higher mortality in cirrhosis
(European Association for the Study of the Liver) Results presented today from a prospective study in patients with irreversible scarring of the liver (cirrhosis) demonstrates that severe periodontitis (an inflammatory gum disease) strongly predicts higher mortality in this population, after adjustments for various risk factors. The study was presented at The International Liver Congress ™ 2017 in Amsterdam, The Netherlands. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 20, 2017 Category: Global & Universal Source Type: news

Worldwide lack of early referral of patients with alcoholic liver disease
(European Association for the Study of the Liver) Results from an analysis of over 3,000 patients highlights there is significant disparity in the referral of patients with liver disease, and that those with alcoholic liver disease (ALD) are 12 times more likely to present at an advanced rather than early stage. The study, presented at The International Liver Congress ™ 2017 in Amsterdam, showed that in those patients with two causes of cirrhosis, alcohol abuse also leads to a more advanced stage of presentation. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 20, 2017 Category: Global & Universal Source Type: news

This molecule stops pancreatic cancer cells from spreading
This micrograph shows pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer). [Image by KGH – Own work, CC BY-SA 3.0]Wake Forest Baptist Medical Center scientists have identified molecules that could be the next therapeutic solution for pancreatic cancer. Pancreatic cancer is one of the most lethal forms of cancer. About 53,670 people are expected to be diagnosed with pancreatic cancer this year with 43,090 dying from it, according to the American Cancer Society. The lifetime risk of developing pancreatic cancer is about 1 in 65 but can be reduced by knowing the risk factors. The risk ...
Source: Mass Device - April 19, 2017 Category: Medical Equipment Authors: Danielle Kirsh Tags: Biotech Oncology Cancer pancreatic cancer Tianjin Medical University University of Texas Wake Forest Baptist Medical Center Source Type: news