Science Saturday: Using AI to reveal causes of complex diseases
Researchers within Mayo Clinic's Center for Individualized Medicine have developed an artificial intelligence (AI) platform that can uncover causal drivers and relationships embedded within complex biomedical data. Nicholas Chia, Ph.D.,?John Kalantari, Ph.D., and Kia Khezeli, Ph.D., recently tested their machine-learning framework, called Causal Relation and Inference Search Platform (CRISP) on multiomic colorectal cancer samples alongside [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 24, 2021 Category: Research Source Type: news

High vaccination rate is key to future course of COVID-19 pandemic, Mayo Clinic computer modeling shows
The Mayo Clinic data scientists who developed highly accurate computer modeling to predict trends for COVID-19 cases nationwide have new research that shows how important a high rate of vaccination is to reducing case numbers and controlling the pandemic. Vaccination is making a striking difference in Minnesota and keeping the current level of positive cases [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 23, 2021 Category: Research Source Type: news

Mayo study finds that pregnancy increases risk for women to develop first-time symptomatic kidney stones
ROCHESTER, Minn. ? Though researchers have long known that several physiological and anatomical changes occur during pregnancy that can contribute to kidney stone formation, evidence of the link has been lacking. But now Mayo Clinic researchers believe they have that evidence. An observational study that reviewed the medical records for nearly 3,000 female patients from [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 15, 2021 Category: Research Source Type: news

Study of mouse gut microbiome may provide clues to how cancer develops in humans
ROCHESTER, Minn. ??A study of the mouse gut microbiome led by researchers from Mayo Clinic may shed light on how cancerous tumors develop and progress in humans. The findings will be presented this evening in a late-breaking abstract (#LB226) at the 2021 American Association for Cancer Research annual meeting. "There is growing recognition that healthy [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 10, 2021 Category: Research Source Type: news

Science Saturday: Neutrophils may lead to cell aging
The action of an immune cell called a neutrophil may contribute to tissue aging, according to a new study. As neutrophils do their job, they may damage chromosomes in nearby cells which, over time, may lead to cellular senescence. This new concept may help clarify cell aging. It also suggests targeting neutrophils might be helpful in [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 10, 2021 Category: Research Source Type: news

Mayo Clinic Q & amp;A podcast: Kidney cancer often found by accident
Your kidneys remove waste from your blood and regulate a healthy balance between water, sodium and minerals in your bloodstream. "Kidneys filter intoxicants, drugs and waste products out of your blood," says Dr. Scott Cheney, a Mayo Clinic urologic surgeon. "We would actually die within about a week without having good kidney function." Poor kidney [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 15, 2021 Category: Research Source Type: news

Science Saturday: Laser therapy for skin regeneration
Mayo Clinic is taking a new approach to bolster the body's ability to heal scar tissue after serious burns. Mayo Clinic dermatologists are using laser treatments to unleash the regenerative power of burned skin and to try to improve appearance and function. Mayo Clinic's Center for Regenerative Medicine is a driver of new regenerative therapeutics that transform the practice [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 13, 2021 Category: Research Source Type: news

Community-based care key to COVID-19 rapid response in underserved communities
U.S. public health officials report that the COVID-19 pandemic has disproportionately affected communities that have been medically underserved, leading to higher infection and mortality rates. A Mayo Clinic study recently published in the American Journal of Public Health says easy access to rapid testing is needed to combat disparities, and a community-driven and culturally tailored [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 9, 2021 Category: Research Source Type: news

Celebrating Mayo Clinic women in medicine on International Women's Day
March is Women's History Month and in honor of International Women's Day on March 8, Mayo Clinic honors and recognizes women's contributions in medicine and research. Mayo Clinic's Center for Individualized Medicine is celebrating the inspirational women who are taking on incredible challenges and leading the way to cure, connect and transform health care. International [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 8, 2021 Category: Research Source Type: news

Science Saturday: Regenerating the larynx for a second chance at speech
Mayo Clinic is leveraging advances in regenerative medicine to restore function for people whose lives have been drastically changed by a laryngectomy -- surgery to remove the voice box. People without a voice box can neither speak with their natural voices nor breathe through their noses. Simple pleasures like smelling a bouquet of flowers or tasting [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 20, 2021 Category: Research Source Type: news

Proton therapy induces biologic response to attack treatment-resistant cancers
ROCHESTER, Minn. -- Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment. The technique is called LEAP, an acronym for "biologically enhanced particle therapy." The findings are published today in Cancer Research, the journal of the American Association for Cancer Research. "The human [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 17, 2021 Category: Research Source Type: news

Mayo Clinic Q & amp;A podcast: Tackling the latest COVID-19 topics
Medical research reveals new information about COVID-19 daily. While scientists and medical experts focus on virus spread, new variants, improved therapeutic treatments and more, it's sometimes difficult for the public to keep up with evolving information. In this Mayo Clinic Q&A podcast, Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 17, 2021 Category: Research Source Type: news

Starting from the beginning may lead to better outcomes for lupus
Lupus is a chronic autoimmune disorder that causes inflammation and pain throughout the body. Most common in women (9 of 10 diagnosed cases); it attacks both joints and organs - including the skin. Lupus is not curable, but symptoms can be managed with medications. Researchers hope to learn more about lupus and identify ways to predict [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 16, 2021 Category: Research Source Type: news

Researchers identify gene implicated in neuroblastoma, a childhood cancer
ROCHESTER, Minn. ? A new study by Mayo Clinic researchers has identified that a chromosome instability gene,?USP24,?is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 15, 2021 Category: Research Source Type: news

Science Saturday: Advancing cell-based regenerative therapy for heart failure
February is American Heart Month, a time to highlight innovative research that seeks to advance cellular therapy as a new option for restoring heart health. One of the latest discoveries in the Center for Regenerative Medicine and Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program established a way to engineer stem cells that activate regenerative mechanisms for healing. This research [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 13, 2021 Category: Research Source Type: news

How emerging variants could affect COVID-19 testing, vaccines and spread
The emergence of new COVID-19 variants has raised many questions about how they may affect the pandemic. Dr. Matthew Binnicker, the director of the Clinical Virology Laboratory at Mayo Clinic and leader of a team that developed a COVID-19 test, answers some of these questions. Watch: Dr. Matthew Binnicker discusses the impact emerging COVID-19 variants [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 12, 2021 Category: Research Source Type: news

First hybrid gene therapy shows early promise in treating long QT syndrome
ROCHESTER, Minn. ? In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. Researchers demonstrated its potential therapeutic efficacy in two in vitro model systems using beating heart cells reengineered from the blood samples of [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 28, 2021 Category: Research Source Type: news

Science Saturday: A mathematical index to distinguish healthy microbiome
What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome -- the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny organisms as a [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 9, 2021 Category: Research Source Type: news

Science Saturday: Conquering cancer by targeting its genetic abnormalities
Joanne Garnett has harrowing memories of that life-changing day back in 1981. She was a 39-year-old land use planner living in Wyoming when she received a call from her doctor confirming she had uterine cancer.  "I was shocked, and it was strange because I didn't fit any profile for uterine cancer," Garnett recalls. "I got a [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 9, 2021 Category: Research Source Type: news

Science Saturday: 10 non-COVID conversation starters for your virtual holiday get-togethers
Holiday gatherings have gone virtual this year, but one thing hasn't changed: the social pressure to find interesting things to say to our relatives. Whether on the phone, or staring blankly at Auntie Carol over Zoom, we all dread that moment of uncomfortable silence. Well fear no more. Everyone likes to talk about their health [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 26, 2020 Category: Research Source Type: news

Will fast-tracked COVID-19 vaccines be safe?
As health care organizations begin planning for distribution of COVID-19 vaccines, many questions are being asked about their safety and efficacy. Dr. Andrew Badley, an infectious diseases physician at Mayo Clinic and head of Mayo Clinic's COVID-19 Research Task Force, offers some insight on how COVID-19 vaccines were fast-tracked to get them ready for the public. Watch: Dr. Andrew Badley [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 9, 2020 Category: Research Source Type: news

Consumer Health: What do you know about COPD?
November is National COPD Awareness Month, which makes it a good time learn more about chronic obstructive pulmonary disease (COPD). COPD is the third leading cause of death by disease in the U.S., with more than 16.4 million people living with the disease, according to the American Lung Association. This chronic inflammatory lung disease is caused by [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 13, 2020 Category: Research Source Type: news

Science Saturday: Turning back the clock on aging
Researchers at Mayo Clinic are probing ways to activate the body's regenerative potential to slow the clock on chronic conditions that set in as we age. From cancer to diabetes to Alzheimer's disease, another birthday adds to a person's risk of developing chronic disease. September is Healthy Aging Month, a time to focus on the positive aspects of aging. Mayo Clinic Center [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 31, 2020 Category: Research Source Type: news

Toxic cellular ooze linked to biological age, disease and disability
Cells in the body usually do what they're told. In response to cues, cells divide, grow, shrink or die as needed. But there are some cells that start to ignore the body's order to expire: senescent cells. Sometimes called "zombie cells" for their undead lingering, senescent cells have triggered the body's kill command, but instead [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 30, 2020 Category: Research Source Type: news

Mayo Clinic Q & amp;A podcast: Digital tools help Mayo Clinic with contact tracing
As positive cases of COVID-19 continue to spike across much of the country, the role of contact tracing to prevent further spread becomes more important. Contact tracing is the process of notifying people who have had close contact with people newly infected with COVID-19, to let them know they may have been exposed. When it [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 29, 2020 Category: Research Source Type: news

Science Saturday: Seeing cancer, but not through a microscope
Toward the end of the 19th century, a French doctor named Ernest Besnier coined the term "biopsy," combining the Greek bios (life) and opsis (a sight). In the decades since, clinicians have performed countless biopsies on suspected cancer patients, all to catch a glimpse of cells on the brink of growing out of control. This [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 24, 2020 Category: Research Source Type: news

Science Saturday: Mining the molecular origins of breast cancer for new cures
October is Breast Cancer Awareness Month, a time to focus on new strategies for prevention and early detection. Mayo Clinic Center for Regenerative Medicine and Mayo Clinic Cancer Center support stem cell biology research to uncover the molecular origins of breast cancer in order to bring new cures to the practice. Answering what are the causes of breast cancer at [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 17, 2020 Category: Research Source Type: news

Women's Wellness: Uterine fibroids are common noncancerous growths
Uterine fibroids are noncancerous growths of the uterus that often appear during childbearing years. Also called leiomyomas (lie-o-my-O-muhs) or myomas, uterine fibroids aren't associated with an increased risk of uterine cancer and almost never develop into cancer. Fibroids range in size from seedlings, undetectable by the human eye, to bulky masses that can distort and [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 16, 2020 Category: Research Source Type: news

Alzheimer's book offers updated resource for patients, care partners
ROCHESTER, Minn. -- Misplacing keys, forgetting the way to a doctor's appointment, trouble recalling a neighbor's name: Are these examples of typical aging? What's the difference between Alzheimer's disease and other forms of dementia? What's actually happening to the brain, and how can you keep it healthy? The second edition "Mayo Clinic on Alzheimer's Disease [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 13, 2020 Category: Research Source Type: news

Science Saturday: Vaccines 101 - The Basics, and COVID-19
Vaccine stories are all around as the world waits for news on the many COVID-19 vaccines working their way through testing. Robert Jacobson, M.D., a Mayo Clinic pediatrician and nationally regarded expert in the delivery of vaccines for children, discusses here the basics of vaccines, making connections from history to the COVID-19 pandemic in a presentation [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 10, 2020 Category: Research Source Type: news

Research of Experimental COVID-19 Therapeutics Explained
As is clear after months of the pandemic, COVID-19 can affect people in a number of ways. Some can be infected and have no symptoms ? what's known as asymptomatic. Others have symptoms, but do not have a serious illness. A third category, however, can require hospitalization for intensive complications. For those with symptoms or [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 4, 2020 Category: Research Source Type: news

Mayo scientists develop mathematical index to distinguish healthy microbiome from diseased
ROCHESTER, Minn. ? What causes some people to develop chronic diseases such as rheumatoid arthritis, cancer and metabolic syndrome while others stay healthy? A major clue could be found in their gut microbiome -- the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 14, 2020 Category: Research Source Type: news

Mayo Clinic Q & amp;A podcast: Heart muscle damage from COVID-19
From the beginning of the COVID-19 pandemic, it was known that the disease affected the lungs. But some of the most severe damage to the body can be to the heart muscle. COVID-related myocarditis, or inflammation of the heart muscle, can cause severe damage and sometimes death. On the Mayo Clinic Q&A podcast, Dr. Leslie [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - August 30, 2020 Category: Research Source Type: news

Phase 3 clinical trial of COVID-19 vaccine underway
As the race to develop a safe and effective vaccine to protect against COVID-19 continues, phase 3 trials of investigational vaccines are underway. In this Q&A, Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research Group, explains the meaning of phase 3, who's being tested and the hopeful outcomes. Watch: [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - August 5, 2020 Category: Research Source Type: news

The effects of COVID-19 on emergency visits, hospitalizations
ROCHESTER, Minn. -- As COVID-19 swept into the U.S., hospitals across the country have reported that their emergency departments are emptying out. In a new study published Monday, Aug. 3, in JAMA Internal Medicine, a team of researchers from multiple institutions provides insights into this phenomenon. "We knew there were major changes in ED (emergency [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - August 2, 2020 Category: Research Source Type: news

Mayo Clinic researchers develop a tissue-derived bioactive gel to stop bleeding, aid in vascular healing
PHOENIX, AZ --Researchers at Mayo Clinic are studying the effects of a tissue-derived bioactive gel they developed to improve endovascular embolization - a minimally invasive procedure used to treat bleeding blood vessels and aneurysms. The results of their latest preclinical study are published in the journal Advanced Materials. Endovascular embolization involves a pinhole puncture in [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 7, 2020 Category: Research Source Type: news

Science Saturday: Crisis inspires innovation
Mayo Clinic has successfully navigated many challenges over our 150-plus year history, including two world wars, the 1918 influenza pandemic and the Great Depression. Our visionary leaders were able to use these inflection points of crisis to catalyze transformational change. Mayo Clinic has an unparalleled resource to lead the response to COVID-19: our organizational values [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 26, 2020 Category: Research Source Type: news

Mayo Clinic launches imaging solution to enable digital pathology across the enterprise
ROCHESTER, Minn. - In support of Mayo Clinic's digital health and practice transformation initiatives, the Mayo Clinic Department of Laboratory Medicine and Pathology has initiated an enterprise-wide digital pathology implementation of the Sectra digital slide review and image storage and management system to enable digital pathology. "As Mayo Clinic continues to lead the transformation of [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 24, 2020 Category: Research Source Type: news

Science Saturday: How vaccines are developed and what that means for COVID-19
In a recent Zoominar, Robert Jacobson, M.D., a Mayo Clinic pediatrician, gave an in-depth, yet easy-to-understand, discussion on vaccine development, and where we are with respect to a vaccine for COVID-19. Dr. Jacobson, who is also a health sciences researcher with specific expertise in pediatric infectious diseases, sets the stage for his discussion with a story about [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 19, 2020 Category: Research Source Type: news

Mayo finds convalescent plasma safe for diverse patients with COVID-19
ROCHESTER, Minn. - Mayo Clinic researchers and collaborators have found investigational convalescent plasma to be safe following transfusion in a diverse group of 20,000 patients. The findings -- from the U.S. Food and Drug Administration's Expanded Access Program for COVID-19 -- are reported in Mayo Clinic Proceedings. The safety report assessed the seven days following [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 17, 2020 Category: Research Source Type: news

Science Saturday: A discovery step toward cell replacement therapy for diabetes
In what could be a step toward cell replacement therapy for diabetes, Mayo Clinic researchers have discovered how to manufacture cells capable of generating a hormone that regulates low blood sugar. Quinn Peterson, Ph.D. and his team have developed a new method of mass producing a cell product containing the hormone glucagon that is capable of protecting against hypoglycemia [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 12, 2020 Category: Research Source Type: news

Mayo researchers define type of Alzheimer's that affects people in their younger years
ROCHESTER, Minn. ? Mayo Clinic researchers have defined a form of Alzheimer's disease that strikes younger people as early as their 40s, presents with atypical symptoms, and affects a different part of the brain not usually associated with Alzheimer's. In their study, the researchers describe a progressive dysexecutive syndrome which they say affects a person's [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 10, 2020 Category: Research Source Type: news

Mayo Clinic identifies factors to predict mortality in pediatric liver transplant
The current system of prioritizing children with liver disease who are waiting for transplantation may not be optimal because the Pediatric End-stage Liver Disease score (PELD) may underestimate risk of dying before a liver transplant in some children if kidney function is not taken into consideration. Adding the values from two additional blood tests, a [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 4, 2020 Category: Research Source Type: news

VIRUS: COVID-19 registry first to track global ICU experience to shed light on trends in care of critically ill patients
MOUNT PROSPECT, Ill -- May 12, 2020 -- The Society of Critical Care Medicine (SCCM) and Mayo Clinic have partnered to launch the first global COVID-19 registry that tracks ICU and hospital care patterns in near real-time. Created by SCCM's Discovery, the Critical Care Research Network, the Viral Infection and Respiratory Illness Universal Study (VIRUS) [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 11, 2020 Category: Research Source Type: news

Mayo Clinic's comprehensive COVID-19 research
"At Mayo, we've developed a comprehensive research portfolio, or what we call a COVID-19 research task force, in order to respond to every area that we need to learn more about this virus. We have scientists doing research in epidemiology. We have people doing research in immunology and vaccine development, in virology, in translational work, in [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 5, 2020 Category: Research Source Type: news

Science Saturday: Regenerative approaches could foster healing from COVID-19
Regenerative Medicine aims not only to repair or restore the function of cells, tissues or organs, but also the whole person. The latter is particularly important amid the COVID-19 pandemic. Regenerative approaches draw on the body's natural abilities to heal, focus on establishing the healing environments and building new, healthy ways of functioning. These aspects of regenerative [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 1, 2020 Category: Research Source Type: news

Science Saturday: Antimalarials, COVID-19, cardiac arrest
Over the last few weeks, chloroquine and hydroxychloroquine have become household words. These antiparasitic drugs normally prescribed for malaria were introduced early in the rush to find potential treatments for COVID-19. As time goes on, the public discussion has centered on who should get these particular drugs and when. Meanwhile many doctors and medical researchers [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 24, 2020 Category: Research Source Type: news

How Mayo Clinic is using artificial intelligence in its COVID-19 research
Artificial intelligence has a vital role in helping researchers in their efforts to fight COVID-19 and is an important tool in the work being done at Mayo Clinic. Dr. Andrew Badley is an infectious diseases specialist and leads Mayo Clinic's COVID-19 Research Task Force. In this Q&A, Dr. Badley answers questions about the task force [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 23, 2020 Category: Research Source Type: news

Science Saturday: The importance of antibody testing in addressing COVID-19
If there's one thing the world has learned so far in the course of the COVID-19 pandemic, it's the important role of testing for the disease. The ability to know who has the virus and who doesn't provides critical information for people and entire regions. Early testing involved collecting cells from the back of the [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 3, 2020 Category: Research Source Type: news

Guidance on patients at risk of drug-induced sudden cardiac death from off-label COVID-19 treatments
ROCHESTER, Minn. ? SARS-CoV-2, the virus that causes COVID-19, continues to spread, leading to more than 20,000 deaths worldwide in less than four months. Efforts are progressing to develop a COVID-19 vaccine, but it's still likely 12 to 18 months away. In the meantime, the pandemic, with over 400,000 confirmed cases worldwide already, is driving [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 24, 2020 Category: Research Source Type: news