Science Saturday: An anti-cancer establishment
In Shakespeare's time, medicine was based on the Hippocratic theory of the four bodily humors, or fluids. Good health was all about keeping these humors in balance, and it was understood that everyone was different. In a sense, today's individualized medical approaches are cycling back to the understanding that we're all unique. Hepatobiliary tumors -- [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 8, 2019 Category: Research Source Type: news

Science Saturday: Sleuthing out the fingerprint of disease
In the winter of 2014, staff of the Newborn Intensive Care Unit had a serious problem. Researchers at Mayo Clinic Hospital -- Rochester, Saint Marys Campus noted a rise in the number of resistant bacteria in the unit. The culprit was methicillin-resistant Staphylococcus aureus, more commonly known as MRSA. Such incidents have become increasingly common in [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 25, 2019 Category: Research Source Type: news

Science Saturday: New genetic test classifies lymphomas
The current diagnostic tools in a pathologist's arsenal sometimes cannot provide a clear distinction between primary mediastinal large B-cell lymphoma (one of the few lymphomas more common in younger women) and diffuse large B-cell lymphoma, the most common type of non-Hodgkin's lymphoma overall. This may occasionally give rise to diagnostic inaccuracy in routine practice and could leave [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 27, 2019 Category: Research Source Type: news

Science Saturday: Short telomere syndromes are like frayed shoe laces
Unlike gray hair, one of the most significant signs of aging is invisible to the naked eye. Deep inside cells, at the tips of thread-like chromosomes, structures known as telomeres protect chromosomes from deterioration--a bit like the way caps at the ends of shoelaces prevent fraying. Telomeres naturally shorten as people age. But sometimes, an [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 20, 2019 Category: Research Source Type: news

Science Saturday: A new era in colon cancer detection and treatment
March is Colorectal Cancer Awareness Month, a time to focus on one of the most common and preventable forms of cancer. Mayo Clinic is applying a new genomic lens to colorectal and other cancers to identify which are the types that run in families. The answer to that could open new treatment options and also [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 23, 2019 Category: Research Source Type: news

Mayo Clinic researchers identify potential new therapy for liver diseases
ROCHESTER, Minn. -- Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers. The study was posted in March on Gastroenterology, the online journal of the American Gastroenterological Association. Print publication is scheduled for July. While therapies have been [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 22, 2019 Category: Research Source Type: news

Science Saturday: A new era in migraine care
For the millions of people who have migraine, the search for pain relief can feel like a nightmare game. "Spin the wheel, see what drug you land on, and just try it. That's the trial-and-error approach that we have had to use in migraine," says?David Dodick, M.D., a neurologist at Mayo Clinic's Arizona campus. The [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 16, 2019 Category: Research Source Type: news

Heart procedure for AFib better than drug therapy for reducing episodes
ROCHESTER, Minn. -- Atrial fibrillation is a common arrhythmia that affects an estimated 30 million people worldwide. New research shows that catheter ablation, a common cardiovascular procedure, appears no more effective than drug therapy to prevent strokes, deaths and other complications in patients with atrial fibrillation. But patients who receive catheter ablation experience much greater [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 15, 2019 Category: Research Source Type: news

Big data adds clarity, certainty to clinical trial outcomes for AFib
ROCHESTER, Minn. -- The 33 million people with atrial fibrillation worldwide not only suffer from bothersome symptoms, but also face a fivefold increased risk of stroke and a twofold increased risk of death. Research teams led by Mayo Clinic published three connected studies on Friday, March 15, clarifying the benefits of catheter ablation versus rate- [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 15, 2019 Category: Research Source Type: news

Mayo Clinic study shows sleep apnea may be tied to increased Alzheimer's biomarker in brain
ROCHESTER, Minn. -- People who stop breathing during sleep may have higher accumulations of the toxic protein tau, a biological hallmark of Alzheimer's disease, in part of the brain that manages memory, navigation and perception of time. A preliminary Mayo Clinic study released Sunday, March 3, will be presented at the American Academy of Neurology's [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 4, 2019 Category: Research Source Type: news

Science Saturday: Leading the charge in regenerative medicine
Regenerative medicine therapies aim to rebuild and restore health to patients challenged by chronic conditions and degenerative diseases. Despite advances in the field, much of the science is still in early research phases, meaning that many treatments haven't been proven safe and effective for humans as standard-of-care therapies yet. Because the scientific process is long, [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - March 2, 2019 Category: Research Source Type: news

Research finds ethnoracial differences in Alzheimer's disease
JACKSONVILLE, Fla -- A team of Mayo Clinic researchers found Hispanic-American patients with Alzheimer's tend to survive significantly longer with the disease than other ethnoracial groups, according to a study in Alzheimer's& Dementia: The Journal of the Alzheimer's Association. Hispanic-Americans were found to live an average of 12 years with the disease from the [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 18, 2019 Category: Research Source Type: news

Science Saturday: Bitten by the virotherapy bug
Every day more than 1,600 Americans die from cancer. Most?of them have cancer that can't be cured with traditional?methods -- surgery, radiation and chemotherapy. The father?of?Evanthia Galanis, M.D., was one of them. He died in the late 1990s from?melanoma?when his daughter was?a junior faculty member at?Mayo Clinic. "My father would have better treatment options today," [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - February 16, 2019 Category: Research Source Type: news

Science Saturday: Brain organoids and neuropsychiatric disorders
Mayo Clinic and Yale University collaborated in a study published in Science to create a new model for studying neuropsychiatric disorders in early human brain development. This unique collaboration brought together Mayo Clinic's team-based, patient-centered research with Yale researchers to discover and analyze the genetic mechanisms that may cause these disorders. The Mayo Clinic team, [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 19, 2019 Category: Research Source Type: news

Mayo Clinic discovers biological markers that could guide treatment for prostate cancer
ROCHESTER, Minn. ? Genetic alterations in low-risk prostate cancer diagnosed by needle biopsy can identify men that harbor higher-risk cancer in their prostate glands, Mayo Clinic has discovered. The research, which is published in the January edition of Mayo Clinic Proceedings, found for the first time that genetic alterations associated with intermediate- and high-risk prostate [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 3, 2019 Category: Research Source Type: news

Obese mice lose anxiety when 'zombie cells' exit their brain
ROCHESTER, Minn. ? Mayo Clinic researchers and collaborators have shown in mice that obesity increases the level of "zombie" or senescent cells in the brain, and that those cells, in turn, are linked to anxiety. When senolytic drugs are used to clear those cells, the anxious behaviors in the mice dissipate. These findings appear in [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - January 3, 2019 Category: Research Source Type: news

Science Saturday: Discovery advances potential individualized treatment for mesothelioma
Large chromosomal rearrangements present in mesothelioma could make it possible to understand which patients are likely respond to immunotherapy,? researchers at the?Mayo Clinic Center for Individualized Medicine? have discovered. The?research?is published in the?Journal of Thoracic Oncology. ?What we?ve shown so far is that these large complex chromosomal rearrangements are frequent in mesothelioma and may provide [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 15, 2018 Category: Research Source Type: news

Sharing Mayo Clinic: An active life restored, thanks to regenerative medicine
For years, Rick Amatuzio lived with severe back pain that kept him from the active life he'd always savored. But advanced diagnostic tests and regenerative medicine therapy at Mayo Clinic ultimately led to a complete recovery. Now Rick once again can play sports and enjoy the outdoors free from pain.? ? A typical weekend for [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 9, 2018 Category: Research Source Type: news

Oxybutynin lessens hot flash frequency, improves breast cancer survivor quality of life, Mayo-led study finds
SAN ANTONIO ? Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, including breast cancer survivors. These findings were presented at the 2018 San [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 7, 2018 Category: Research Source Type: news

Science Saturday: Potential and pitfalls of gene therapy
Research is advancing gene therapy as a possible treatment or eventual cure for genetic diseases that bedevil modern science. Gene therapy was conceived over 20 years ago, and until recently, remained largely in the research lab. But gene therapy products are now beginning to be approved by the U.S. Food and Drug Administration for clinical [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - December 1, 2018 Category: Research Source Type: news

Father's disease inspires son's journey to find a cure
It's amazing how far some people will go to accomplish their dream. Dr. Fouad Chebib grew up in a small town in Lebanon. After finishing medical school in Lebanon's capital city, Beirut, Dr. Chebib chased his dream across the world to Mayo Clinic in Rochester, Minnesota. "I'm one of the kidney doctors," Dr. Chebib says. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 21, 2018 Category: Research Source Type: news

Science Saturday: Novel data-driven approach for precision medicine
Thousands of patients? tumors have been sequenced in the past decade, yielding a rich source of data on the changes associated with the cancer development and treatment response. However, there are no validated methods that are used in the clinic to select the best therapy. Today, Mayo Clinic researchers report an omics-guided (comprehensive) drug prioritization [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 17, 2018 Category: Research Source Type: news

Science Saturday: Brainstorming on epilepsy
Epilepsy strikes without warning, when an electrical storm sweeps across the brain. Storm-chasing teams of researchers have adopted computational techniques to pinpoint and predict seizure activity.?? Where exactly does a seizure originate? How can the onset of a seizure be predicted? The emerging answers to these mysteries have two things in common: epilepsy, one of [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 3, 2018 Category: Research Source Type: news

November is C. diff Awareness Month. Mayo Clinic experts available for interviews
ROCHESTER, Minn. ??November is C. diff awareness month, a time to focus on raising awareness about the prevention and treatment of Clostridium Difficile Infections. Mayo Clinic experts are available for interviews. ?C. diff is a bacterial infection that causes symptoms ranging from diarrhea to life-threatening inflammation of the colon,? says Darrell Pardi, M.D., a gastroenterologist [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 1, 2018 Category: Research Source Type: news

Science Saturday: How bread yeast and book damage help clarify epigenetics
Genes don't change, but how they are used by the body can.? That shift in use (which is called epigenetics) can mean the difference between illness and health. To better understand how that happens Mayo researchers are examining how genes are activated (used) and copied. With a recent publication in the journal?Science, a team of [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 13, 2018 Category: Research Source Type: news

Mayo Clinic researchers identify gene types driving racial disparities in myeloma
ROCHESTER Minn. ? Researchers at Mayo Clinic have identified three specific gene types that account for a known two-to-three-fold increase in myeloma diagnoses among African-Americans. Researchers also demonstrated the ability to study race and racial admixture more accurately using DNA analysis. The findings were published today in Blood Cancer Journal. ??Myeloma is a serious blood [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 10, 2018 Category: Research Source Type: news

Science Saturday: Research News Roundup -- September 2018
This article includes brief summaries and links to news releases from the preceding month that discuss some of our latest medical research. It also connects readers to related resources. Read on for recent findings of?Mayo Clinic Research: Mayo Clinic researchers receive Specialized Program of Research Excellence [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 6, 2018 Category: Research Source Type: news

Liver transplant, weight-loss surgery combination benefits obese patients in long term
ROCHESTER, Minn. ? Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows. The findings were recently published [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 2, 2018 Category: Research Source Type: news

Mayo researchers develop new genetics-based prognostic tool for myelodysplastic syndrome
ROCHESTER, Minn. ? Researchers at Mayo Clinic have developed a new genetics-based prognostic tool for myelodysplastic syndrome. Their findings are published in the October print issue of Mayo Clinic Proceedings. ?Myelodysplastic syndrome is one of the most frequent blood cancers affecting the elderly with annual incidence exceeding 50 cases per 100,000 in people 65 years [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 1, 2018 Category: Research Source Type: news

Science Saturday: Research helps play it safe in the ICU
ICU use of PTZ/VAN combo therapy safe for kidneys Life threatening infections, or sepsis, are one of the most common reasons people end up in the intensive care unit or stay longer in the hospital than originally expected. To combat these infections, physicians can choose from several antibiotics, and often will use a combination of [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 29, 2018 Category: Research Source Type: news

Mayo Clinic researchers receive Specialized Program of Research Excellence grant for liver and biliary cancer from the National Cancer Institute
ROCHESTER Minn. ? A team of researchers from the Mayo Clinic Cancer Center has been awarded a five-year, $11.5-million Specialized Program of Research Excellence (SPORE) grant in liver and biliary tract cancer from the National Cancer Institute (NCI). Specialized Program of Research Excellence grants are designed to promote interdisciplinary research and help basic research findings [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 28, 2018 Category: Research Source Type: news

Spinal cord stimulation, physical therapy help paralyzed man stand, walk with assistance
ROCHESTER, Minn. ? Spinal cord stimulation and physical therapy have helped a man paralyzed since 2013 regain his ability to stand and walk with assistance. The results, achieved in a research collaboration between Mayo Clinic and UCLA, are reported in Nature Medicine. With an implanted stimulator turned on, the man, Jered Chinnock, was able to [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 24, 2018 Category: Research Source Type: news

Science Saturday: Deep space medicine research program to improve health on Earth
A full year before?Alejandro Rabinstein, M.D., was born in Cordoba, Argentina, Apollo 11 made the first?successful landing on the moon and U.S. astronaut Neil?Armstrong became the first person to set foot on another planet.?That was the summer of 1969. Forty-eight years later, Dr. Rabinstein?has become Mayo Clinic?s expert on deep space travel medicine ? a?role [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - September 22, 2018 Category: Research Source Type: news

Science Saturday: Offering underserved groups access to cutting-edge research
Groups such as racial minorities, older individuals, and those with low income are less likely than others to participate in clinical trials, according to government agencies. For example, the U.S. Food and Drug Administration?reports?that racial and ethnic minority groups represent only 19 percent of drug trial participants in the U.S., yet these groups make up [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 21, 2018 Category: Research Source Type: news

Mayo Clinic researchers uncover methods to quantify the yips and golfer's cramp
The findings could open the door to improved treatment options SCOTTSDALE, Ariz. ? Almost every golfer knows the feeling. Minutes after a picture-perfect drive down the fairway, a cascade of inexplicable missed putts leads to a disappointing triple bogey. Golfers? lapses in play sometimes are blamed on a mysterious twitching condition called "the yips." But [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 19, 2018 Category: Research Source Type: news

Anesthesia, surgery linked to subtle decline in memory and thinking in older adults, Mayo study finds
ROCHESTER, Minn. ? In adults over 70, exposure to general anesthesia and surgery is associated with a subtle decline in memory and thinking skills, according to new Mayo Clinic research. The study analyzed nearly 2,000 participants in the Mayo Clinic Study of Aging and found that exposure to anesthesia after age 70 was linked to [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 19, 2018 Category: Research Source Type: news

Senolytics improve health, extend life: Preclinical research findings
ROCHESTER, Minn. ? The presence of senescent or dysfunctional cells can make young mice age faster. And using senolytic drugs in elderly mice to remove these rogue cells can improve health and extend life. These findings from Mayo Clinic researchers and collaborators provide a foundation on which to move forward in this area of aging [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 9, 2018 Category: Research Source Type: news

Mayo researchers find off/on switch for DNA repair protein
ROCHESTER, Minn. ? Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural& Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. The authors say they hope this discovery research [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - July 2, 2018 Category: Research Source Type: news

Science Saturday: Building a scientific collaborative space
Combining innovative Mayo Clinic labs with medical businesses and creative start-up companies will help Rochester ? and benefit patients. Outside his office in the Destination Medical Center Economic Development Agency, Chris Schad leans over a model of downtown Rochester, Minn. He traces out Discovery Square ? the 16-block area south of the main Mayo Clinic [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 30, 2018 Category: Research Source Type: news

Women's Wellness: Hot flashes and night sweats happen after menopause
Menopause symptoms are not just for midlife anymore, according to a Mayo Clinic study published in the Journal of the North American Menopause Society. The study, conducted by researchers at Mayo Clinic gathered data from nearly 5,000 women. When asked whether they experienced any symptoms commonly associated with menopause, such as hot flashes and night [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 28, 2018 Category: Research Source Type: news

Science Saturday: The collective wisdom of biobanks
Since ancient times physicians have analyzed patient specimens to diagnose illness. Now, our samples can do far more than diagnose. They can help researchers find treatments for the unmet needs of patients. ?A biobank is a collection of biological samples from a large number of patients,? explains?Stephen Thibodeau, Ph.D., co-director of the?Biorepositories Program in the [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - June 9, 2018 Category: Research Source Type: news

Mayo study identifies new potential treatment option for triple negative breast cancer
In this study, Mayo investigators identified that the [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 16, 2018 Category: Research Source Type: news

Mayo discovery means individualized ovarian, brain cancer therapies
ROCHESTER, Minn. ??Mayo Clinic researchers have discovered that a molecular communication pathway ? thought to be defective in cancer ? is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers. This discovery enabled researchers to develop an algorithm to predict treatment effectiveness in individual patients. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 16, 2018 Category: Research Source Type: news

Children?s Hospital Colorado, Mayo Clinic announce collaboration on rare congenital heart defect
AURORA, Colorado ? Mayo Clinic?s Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome and Children?s Hospital Colorado are collaborating to provide solutions for patients with hypoplastic left heart syndrome, a rare and complex form of congenital heart disease in which the left side of the heart is severely underdeveloped. ?We are thrilled [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 8, 2018 Category: Research Source Type: news

Mayo Clinic joins NIH in launching All of Us Research Program
ROCHESTER, Minn. ? On May 6, the National Institutes of Health (NIH) will open national enrollment for the All of Us Research Program. According to the NIH the program is a momentous effort to advance individualized prevention, treatment and care for people of all backgrounds. All of Us seeks to transform the relationship between researchers [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - May 1, 2018 Category: Research Source Type: news

Mayo Clinic Minute: Why breakfast may be key to trimming your belly
If you're wanting to lose pounds and your belly, breakfast may be your best friend. "For reasons that we don't quite understand yet, eating breakfast? seems to be a marker of, No. 1, less likelihood of having gained weight recently, and, No. 2, ... a smaller belly circumference and less visceral fat," Dr. Virend Somers, [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 25, 2018 Category: Research Source Type: news

Transplanted livers help body defend against organ rejection, Mayo Clinic study finds
ROCHESTER, Minn. ??Transplanted livers change the profile of blood cells in the recipients, reducing the potential for organ rejection, Mayo Clinic research shows. The findings are published in Kidney International. For decades, transplant experts have observed that liver transplant recipients often need less anti-rejection medication, known as immunosuppressive drugs, than recipients of other solid organs. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 18, 2018 Category: Research Source Type: news

Science Saturday: Discovering a missing link in DNA damage repair
For years, researchers have known that our genome is protected by a system of detection, evaluation and repair processes that activate any time DNA damage occurs. Upon detection, the damage is assessed, repaired in one way or another, or, if it can?t be repaired the cell is cued to self-destruct. Much of that effort is [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 14, 2018 Category: Research Source Type: news

New definition of Alzheimer's changes how disease is researched
When you think of dementia, most people automatically think of Alzheimer's disease, too. But, under a new definition of Alzheimer's, the two terms no longer will be considered interchangeable. The new definition is part of a new framework for researching Alzheimer's disease that the?Alzheimer's Association and the National Institute on Aging developed and released. https://youtu.be/L9uCBaHrPYc [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 10, 2018 Category: Research Source Type: news

#MayoClinicRadio podcast: 4/7/18
Listen: Mayo Clinic Radio 4/7/18 On the Mayo Clinic Radio podcast, Dr. Timothy Curry, education program director at the Mayo Clinic Center for Individualized Medicine, discusses pharmacogenomics testing. Dr. Curry?is joined by?Dr. Michael Stephens, division chair of Pediatric Gastroenterology and Hepatology at Mayo Clinic, to share how his own pharmacogenomics testing revealed some surprising results. [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - April 9, 2018 Category: Research Source Type: news