Fight Aging! Newsletter, February 21st 2022

In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far. Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/ In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and here the focus is on immune cells in the brain. A growing body of evidence points to microglia, innate immune cells of the central nervous system, as an important contributing cause of age-related neurodegeneration. These cells react to increased molecular damage, inflammatory signaling generated by senescent cells, and so forth, all of which is far more prevalent in the old brain than in the young brain. They become activated and inflammatory. The result is chronic inflammation in brain tissue and consequent disruption of cell and tissue function. From a self-experimenter's perspective, Mycobacterium vaccae immunization is an interesting approach. Large clinical trials of Mycobacterium vaccae immunization have taken place for reasons unrelated to inflammation, and thus a good deal of safety data already exists. A quick look online suggests that it is pr...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs