Big biotech, UCs launch $53M effort targeting Alzheimer's, other brain diseases
UCSF and UC Berkeley will receive $53 million over 10 years as part of a collaboration with biotech giant Genentech Inc. and its Swiss parent Roche to research potential new treatments for Alzheimer's, Huntington's and Parkinson's diseases, ALS, autism and other central nervous system conditions. The partnership builds on a University of California-University of Washington effort started in 2019 and backed by the foundation of former Citibank CEO Sandy Weill and his wife, Joan, and it will initially… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 25, 2021 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

New therapeutic target for Huntington's treatment
(University of Barcelona) Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 23, 2021 Category: International Medicine & Public Health Source Type: news

Basic cell health systems wear down in Huntington's disease, novel analysis shows
(Picower Institute at MIT) A new computational approach for analyzing complex datasets shows that as disease progresses, neurons and astrocytes lose the ability to maintain homeostasis. The " Geomic " approach can be applied to other diseases, authors say. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 23, 2021 Category: International Medicine & Public Health Source Type: news

After the Nobel, what next for Crispr  gene-editing therapies?
Hailed as the ‘molecular scissors’ that will allow us to rewrite our genes, the DNA tool is being trialled in treatments for everything from sickle-cell anaemia to cancerWhen last year ’s Nobel prize for chemistry was awarded tobiochemist Jennifer Doudna and microbiologist Emmanuelle Charpentier for their work in developing the technique of gene editing known as Crispr-Cas9 (pronounced “crisper”), headlines hailed their discovery as “molecular scissors” that would allow us to “rewrite the book of life” – with all the complicated ethical questions that ability rais...
Source: Guardian Unlimited Science - February 21, 2021 Category: Science Authors: Philip Ball Tags: Gene editing Medical research Genetics Biology Science Cancer Huntington's disease Sickle cell disease Source Type: news

To boost outdoor dining, Huntington Beach may extend Main Street closure for summer
The second block of Main Street, which has been closed since last summer to promote outdoor dining, could stay closed through Labor Day. (Source: L.A. Times - Health)
Source: L.A. Times - Health - February 16, 2021 Category: Consumer Health News Authors: Matt Szabo Source Type: news

Sir Peter Harper obituary
Researcher into the genetics of neurological disorders whose work has provided hope for a cure for muscular dystrophyPeter Harper, who has died aged 81, was a world expert on the genetics of inherited neurological disorders, particularlyHuntington ’s disease andmuscular dystrophy. He also advocated the idea of genetic counselling – helping people to understand the implications of inherited disorders that might affect them and their families.Finding a genetic link between the two wasting conditions has led to highly accurate diagnostic and predictive tests for at-risk individuals and their families. Peter played...
Source: Guardian Unlimited Science - February 15, 2021 Category: Science Authors: Peter McGuffin Tags: Genetics Medicine Science Education Biology Huntington's disease Source Type: news

New insight into protein structures that could treat Huntington's disease
(University of Groningen) In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein. However, it is not well known how these proteins interact with the Huntington's disease protein. New research by Patrick van der Wel (University of Groningen) and colleagues at the University of Texas has partially resolved the structure of heat shock proteins that bind to such aggregating proteins. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 12, 2021 Category: International Medicine & Public Health Source Type: news

About 60 Huntington Beach high school teachers take leave due to on-campus requirement
The Huntington Beach Union High School District has been requiring its teachers to be on campus since the second semester began on Feb. 2. (Source: L.A. Times - Health)
Source: L.A. Times - Health - February 12, 2021 Category: Consumer Health News Authors: Matt Szabo Source Type: news

Insights into the role of DNA repair and Huntington's disease gene mutation open new avenues for drug discovery
(IOS Press) DNA repair is an important factor that determines how early or late Huntington's disease (HD) occurs in individuals who carry the expanded CAG repeat in the HTT gene that causes HD. This special issue of theJournal of Huntington's Disease is a compendium of new reviews on topics ranging from the discovery of somatic CAG repeat expansion in HD, to our current understanding of the molecular mechanisms involved and the development of potential new therapies targeting these mechanisms. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2021 Category: International Medicine & Public Health Source Type: news

NIH Director Francis Collins Is Fighting This Coronavirus While Preparing for the Next One
In May 2020, Dr. Francis Collins, the longtime head of the National Institutes of Health (NIH), was called to the White House to meet with Jared Kushner, the then President’s son-in-law and adviser, and Dr. Deborah Birx, the head of the White House Coronavirus Task Force. A few weeks earlier, Congress had given the NIH $1.5 billion to try to speed up the process of developing new diagnostic tests for COVID-19, and the White House, which was dubious about increasing the rate of testing, wanted to know more about what the NIH was doing. Collins is technically the boss of Dr. Anthony Fauci, but during the pandemic he ha...
Source: TIME: Health - February 4, 2021 Category: Consumer Health News Authors: Belinda Luscombe Tags: Uncategorized COVID-19 feature Magazine Source Type: news

Researchers describe a molecular mechanism involved in the pathology's neurodegeneration
(University of Barcelona) Protein alteration in the family of lamins causes several diseases, known as laminopathies, such as progeria or precocious ageing. A study in which UB researchers have taken part states that alterations in the levels of one of these proteins, lamin B1, contribute to the degeneration of neuronal populations in Huntington's disease. Caused by a mutation in the huntingtin gen, this pathology features involuntary movements, cognitive deficit and psychiatric disorders, and has no cure yet. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2021 Category: International Medicine & Public Health Source Type: news

Huntington Beach City Council to vote on removing Tito Ortiz as mayor pro tem
Tito Ortiz was elected with the most votes in city history in November, but he might have his title stripped at Monday's City Council meeting. (Source: L.A. Times - Health)
Source: L.A. Times - Health - January 30, 2021 Category: Consumer Health News Authors: Matt Szabo Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS Patient Care - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS Administration and Leadership - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS Latest News - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS: Journal of Emergency Medical Services News - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS Operations - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

EMT, Good Samaritans Pull Driver from Burning Car after NY Crash
Michael Sheridan New York Daily News (MCT) A 34-year-old man was pulled from a burning car by an EMT and two Good Samaritans after crashing on the Long Island Expressway Tuesday, authorities said. The unidentified driver was heading west when he lost control near Exit 43 in Woodbury and crashed his 2012 Audi just before 3 p.m., Nassau County police said Wednesday. The car smashed into a cement barrier before hitting the Seaford Oyster Bay Expressway overpass. Dale Bartolomeo, an FDNY EMT who also volunteers with the Huntington Manor Fire Department, saw the c...
Source: JEMS Special Topics - January 7, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: News News Feed Rescue & Vehicle Extrication Spotlight New York Source Type: news

Protesters decry Huntington Beach Mayor Pro Tem Tito Ortiz for not wearing a mask during food drive
The mayor pro tem gave away Christmas dinners maskless on Wednesday, in association with the Kiwanis Club of Huntington Beach. (Source: L.A. Times - Health)
Source: L.A. Times - Health - December 24, 2020 Category: Consumer Health News Authors: Matt Szabo Source Type: news

Community-level risk & protective correlates of violent crimes - Reidy DE, Huntington C, Smith HW, Bogen KW, Estefan LF, Orchowski LO.
Despite declining rates over the past several decades, violence continues to be a pervasive public health problem. To date, we have very little knowledge about the factors at the outer layers of the social ecology that may serve to protect or exacerbate vi... (Source: SafetyLit)
Source: SafetyLit - December 23, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Huntington Harbour Boat Parade a go, but traveling to see it is discouraged
Other Orange County cities have canceled similar holiday events, but around 70 boats are expected this weekend in Huntington Beach. (Source: L.A. Times - Health)
Source: L.A. Times - Health - December 11, 2020 Category: Consumer Health News Authors: Matt Szabo Source Type: news

NIH researchers link cases of ALS and FTD to a mutation associated with Huntington ’s disease
Previously unknown genetic connection could be a target for gene therapy. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 4, 2020 Category: American Health Source Type: news

NIH researchers link cases of ALS and FTD to a Huntington's disease-associated mutation
(NIH/National Institute of Neurological Disorders and Stroke) A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease. This large, international project, which included a collaboration between the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), opens a potentially new avenue for diagnosing and treating some individuals with FTD or ALS. (...
Source: EurekAlert! - Medicine and Health - December 4, 2020 Category: International Medicine & Public Health Source Type: news

Letters to the Editor: Right-wing media have turned Huntington Beach into Angrytown
In the right-wing media, liberals are lazy and dangerous, and Gov. Gavin Newsom is destroying the Constitution instead of battling a pandemic. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 29, 2020 Category: Consumer Health News Source Type: news

Suicide in frontotemporal dementia and Huntington disease: analysis of family-reported pedigree data and implications for genetic healthcare for asymptomatic relatives - Sexton A, West K, Gill G, Wiseman A, Taylor J, Purvis R, Fahey M, Storey E, Walsh M, James P.
OBJECTIVE: Genomic testing for early-onset dementia is becoming more accessible, along with predictive testing for at-risk relatives; however, complex counselling issues are important to address. The topic of suicide often has stigma associated, and though... (Source: SafetyLit)
Source: SafetyLit - November 27, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Column: How Huntington Beach became Angrytown, USA
Huntington Beach has always been conservative, but the governor, masks rules and a new coronavirus curfew have fueled all-out rage. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 24, 2020 Category: Consumer Health News Authors: Gustavo Arellano Source Type: news

Protesters demonstrate in Huntington Beach in defiance of coronavirus curfew
Protesters gathered Saturday at Huntington Beach Pier in defiance of the state's coronavirus curfew that went into effect at 10 p.m. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 22, 2020 Category: Consumer Health News Authors: Rosanna Xia Source Type: news

Local Theaters Get Creative – And Go Digital – To Survive COVID
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 18, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Covid-19 Boston, MA Entertainment Events Seen On WBZ-TV Beverly News Coronavirus Source Type: news

One of L.A.'s most important art exhibitions is stuck in COVID-19 limbo
The Hammer Museum's 2020 biennial, this year presented with the Huntington, waits for pandemic restrictions to lift. It could take months — or not happen at all. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 12, 2020 Category: Consumer Health News Authors: Deborah Vankin Source Type: news

Review: Extreme alienation reigns in the Hammer Museum's (unopened) biennial
Abhorrence is an undercurrent of "Made in L.A.," this year installed at the Hammer and the Huntington — both still waiting to reopen galleries closed by COVID-19. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 10, 2020 Category: Consumer Health News Authors: Christopher Knight Source Type: news

Letters to the Editor: What's the point of mask mandates without penalties?
Refusing to wear a mask may be just as dangerous as drunk driving, an offense for which there are penalties, a retired Huntington Beach doctor writes. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 1, 2020 Category: Consumer Health News Source Type: news

Study helps explain why motivation to learn declines with age
(Massachusetts Institute of Technology) MIT neuroscientists have identified a brain circuit critical for learning to make decisions that require evaluating the cost or reward of an action. They showed this circuit is negatively affected by aging and in Huntington's disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 28, 2020 Category: International Medicine & Public Health Source Type: news

Restaurant workers face smaller tips, mask resistance as Huntington Beach struggles with COVID-19 slump
Two customers on the outdoor patio. $6 in a tip jar labeled 'For College'. Few masks in sight. This is the reality of Huntington Beach service workers during the pandemic. (Source: L.A. Times - Health)
Source: L.A. Times - Health - October 22, 2020 Category: Consumer Health News Authors: Stephanie Lai Source Type: news

FDA places hold on Huntington's gene therapy trial
A clinical hold has been placed on Voyager's potential Huntington ’s disease drug, VY-HTT01. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 13, 2020 Category: American Health Authors: Allison DeAngelis Source Type: news

Enhancing the clinical utility of DriveSafe DriveAware for people with Huntington's disease - Sondhu MK, Fisher F, Stout JC.
DriveSafe DriveAware (DSDA) is a cognitive screening tool assessing driving safety. Previously, we found DSDA categorised some HD participants as 'likely to pass' on-road assessments, despite displaying cognitive impairments in domains known to impact driv... (Source: SafetyLit)
Source: SafetyLit - October 9, 2020 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

The magical new Chinese Garden at the Huntington is the getaway you need right now
The final phase of the Huntington's famed Chinese Garden is scheduled to open Oct. 9, with an additional 11.5 acres, or 15 acres total with new pavilions, landscaping and — someday — even restaurants. (Source: L.A. Times - Health)
Source: L.A. Times - Health - October 8, 2020 Category: Consumer Health News Authors: Jeanette Marantos Source Type: news

How to keep Trader Joe's orchids alive and other tips from the Huntington's expert
The No. 1 reason people kill their orchids is they overwater them. An expert offers tips on how to keep them alive. (Source: L.A. Times - Health)
Source: L.A. Times - Health - October 2, 2020 Category: Consumer Health News Authors: Lisa Boone Source Type: news

Michelle Gray Tracks Huntington ’s in Different Brain Cells
The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease ’s initiation and progression. (Source: The Scientist)
Source: The Scientist - October 1, 2020 Category: Science Tags: Scientist to Watch Source Type: news

Disrupted Glycosylation Causes Neurodegeneration Disrupted Glycosylation Causes Neurodegeneration
This paper discusses dysfunction of glycosyltransferases as a factor and potential therapeutic target in neurodegenerative diseases including ALS, Alzheimer, Huntington, and Parkinson disease.Brain (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 22, 2020 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Dementia symptoms: Does this happen to your face? It could be a sign of brain decline
DEMENTIA comes in many different forms and the range of possible symptoms reflects this. The main warning sign of Huntington's disease - a type of dementia - is associated with the face. (Source: Daily Express - Health)
Source: Daily Express - Health - September 15, 2020 Category: Consumer Health News Source Type: news

California's creek fire creates its own pyrocumulonimbus cloud
(NASA/Goddard Space Flight Center) On Friday September 4, 2020 at about 6:44 PM PDT the Creek Fire began in the Big Creek drainage area between Shaver Lake, Big Creek and Huntington Lake, Calif. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 8, 2020 Category: Biology Source Type: news

The rotten-smelling corpse flower is about to bloom. Here's how to watch it live.
The corpse flower blooms rarely and briefly at the Huntington. Watch it unfurl live on YouTube. (Source: L.A. Times - Health)
Source: L.A. Times - Health - August 28, 2020 Category: Consumer Health News Authors: Lisa Boone Source Type: news

The rotten-smelling corpse flower is about to bloom. Here's how to watch it live
The corpse flower blooms rarely and briefly at the Huntington. Watch it unfurl live on YouTube. (Source: L.A. Times - Health)
Source: L.A. Times - Health - August 28, 2020 Category: Consumer Health News Authors: Lisa Boone Source Type: news

A second L.A. Metro bus driver has died of complications from COVID-19
The driver, a 22-year veteran of the agency, most recently drove on Line 611, through Cudahy and Huntington Park. (Source: L.A. Times - Health)
Source: L.A. Times - Health - August 27, 2020 Category: Consumer Health News Authors: Laura J. Nelson Source Type: news

An early start to Huntington's disease
(Source: ScienceNOW)
Source: ScienceNOW - August 12, 2020 Category: Science Authors: DiFiglia, M. Tags: Neuroscience perspective Source Type: news

Huntingtons disease alters human neurodevelopment
Although Huntington’s disease is a late-manifesting neurodegenerative disorder, both mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that Huntington’s disease might affect neurodevelopment. To determine whether this is actually the case, we examined tissue from human fetuses (13 weeks gestation) that carried the Huntington’s disease mutation. These tissues showed clear abnormalities in the developing cortex, including mislocalization of mutant huntingtin and junctional complex proteins, defects in neuroprogenitor cell polarity and differentiation, abnormal ciliogenesis, ...
Source: ScienceNOW - August 12, 2020 Category: Science Authors: Barnat, M., Capizzi, M., Aparicio, E., Boluda, S., Wennagel, D., Kacher, R., Kassem, R., Lenoir, S., Agasse, F., Braz, B. Y., Liu, J.-P., Ighil, J., Tessier, A., Zeitlin, S. O., Duyckaerts, C., Dommergues, M., Durr, A., Humbert, S. Tags: Development, Medicine, Diseases, Neuroscience r-articles Source Type: news

Biotech Vico Therapeutics raises $31 million (€27 million) in Series A financing round to advance therapies for rare central nervous system diseases
AON-platform with focus on therapies nearing phase I trials for forms of Spinocerebellar Ataxia and Huntington Disease Other early discovery stage RNA editing platform focuses on RETT syndrome Funding led by LSP, co-led by Kurma Partners, supported b... Biopharmaceuticals, Neurology, Venture Capital Vico Therapeutics, RNA modulating therapies (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 29, 2020 Category: Pharmaceuticals Source Type: news

Church services move to California beaches, sparking fears of coronavirus outbreaks
Huntington Beach and Cardiff State Beach in San Diego County have both seen large outdoor church gatherings, alarming public health officials. (Source: L.A. Times - Health)
Source: L.A. Times - Health - July 28, 2020 Category: Consumer Health News Authors: Alex Wigglesworth, Paul Sisson Source Type: news

Food giveaway in Fountain Valley helps families deal with coronavirus
The Boys & Girls Clubs of Huntington Valley put on a food giveaway at Fountain Valley Recreation Center and Sports Park to help out families in need during the coronavirus pandemic. (Source: L.A. Times - Health)
Source: L.A. Times - Health - July 27, 2020 Category: Consumer Health News Authors: Andrew Turner Source Type: news

'I don't believe it': Huntington Beach a symbol of mask resistance as doubters abound
As infection rates soar in Orange County, residents of Surf City doubt the severity of the pandemic and call for easing restrictions. (Source: L.A. Times - Health)
Source: L.A. Times - Health - July 22, 2020 Category: Consumer Health News Authors: Jake Sheridan Source Type: news