PRIME designation granted by European Medicines Agency for RG6042 for treatment of Huntington ’s disease
Roche today announced that the European Medicines Agency (EMA) has granted PRIME (PRIority MEdicines) designation for the company ’s investigational medicine RG6042 (formerly known as IONIS-HTTRx) for the treatment of people with Huntington’s disease (HD). (Source: Roche Media News)
Source: Roche Media News - August 3, 2018 Category: Pharmaceuticals Source Type: news

PRIME designation granted by European Medicines Agency for RG6042 for treatment of Huntington ’s disease
Roche today announced that the European Medicines Agency (EMA) has granted PRIME (PRIority MEdicines) designation for the company ’s investigational medicine RG6042 (formerly known as IONIS-HTTRx) for the treatment of people with Huntington’s disease (HD). (Source: Roche Investor Update)
Source: Roche Investor Update - August 3, 2018 Category: Pharmaceuticals Source Type: news

Researchers discover system that could reduce neurodegeneration in Huntington's disease
(University of Cologne) The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne's Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease. Particularly, they identified a system blocking the accumulation of toxin protein aggregates, which are responsible for neurodegeneration. The results have now been published in the journal 'Nature Communications'. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 26, 2018 Category: International Medicine & Public Health Source Type: news

New system can identify drugs to target 'undruggable' enzymes critical in many diseases
(Medical Research Council) A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly 'undruggable'. The study, published in Cell, demonstrated the capabilities of the new system by identifying a molecule that could successfully target a phosphatase to reduce the accumulation of Huntington's disease-associated proteins in the brains of mice. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 26, 2018 Category: International Medicine & Public Health Source Type: news

IMI Launches New Antimicrobial Resistance Accelerator Programme as Part of Latest Calls for Proposals
A new Antimicrobial Resistance (AMR) Accelerator Programme is part of new Calls for proposals launched today by the Innovative Medicines Initiative (IMI). Of the other topics launched in the Calls, many address brain disorders (e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, major depression) and immune-mediated diseases (e.g. rheumatoid arthritis and lupus as well as inflammatory bowel diseases such as Crohn's and colitis, and skin diseases like dermatitis and psoriasis). (Source: eHealth News EU)
Source: eHealth News EU - July 18, 2018 Category: Information Technology Tags: Featured Open Calls Source Type: news

Complex brain circuitry revealed using new single-cell sequencing technology
(The Translational Genomics Research Institute) Researchers at TGen and Circuit Therapeutics Inc. are studying the brain's striatum, which not only is responsible for controlling how we move, but also contributes to the brain's decision-making and the initiation of action. Nearly 95 percent of the cells that make up the striatum are known as medium spiny neurons (MSN), which is associated with many psychiatric and neurodegenerative diseases, including Parkinson's disease, Huntington's disease, schizophrenia, drug addition and ADHD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 5, 2018 Category: International Medicine & Public Health Source Type: news

Evaluating depression and suicidality in tetrabenazine users with Huntington disease - Schultz JL, Killoran A, Nopoulos PC, Chabal CC, Moser DJ, Kamholz JA.
OBJECTIVE: To determine whether tetrabenazine (TBZ) use is associated with an increased incidence of depression and/or suicidal ideation. METHODS: In this retrospective cross-sectional study of the Enroll-HD database, we used multiple logistic regr... (Source: SafetyLit)
Source: SafetyLit - June 26, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

Nuclear Engineering expert honored by Health Physics Society
(Rensselaer Polytechnic Institute) Nuclear engineering expert George Xu, the Edward E. Hood Jr. Endowed Chair of Engineering at Rensselaer Polytechnic Institute, has been selected to receive the Distinguished Scientific Achievement Award of the Health Physics Society. The award will be given during the 2018 Annual Meeting in Cleveland, Ohio, July 15-19 at the Huntington Cleveland Convention Center. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 22, 2018 Category: Biology Source Type: news

Researchers find important new piece in the Huntington's disease puzzle
(University of Copenhagen The Faculty of Health and Medical Sciences) In a new study, researchers from the University of Copenhagen have discovered a hitherto unknown error in the transport of glutamine between astrocytes and neurons in the brain of mice with Huntington's disease. At the same time, it is a relevant area on which to focus the effort of developing a future treatment for the disease, the researchers believe. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 20, 2018 Category: International Medicine & Public Health Source Type: news

Do RA and Huntington's Disease Share Epigenetic Link?
(MedPage Today) -- Study using cells from RA joints identified an association (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - May 26, 2018 Category: Neurology Source Type: news

Exposures to single-use detergent sacs reported to a statewide poison control system, 2013-2015 - Vohra R, Huntington S, Fenik Y, Phan D, Ta N, Geller RJ.
BACKGROUND: Single-use detergent sacs (SUDSs) represent a relatively new household hazard to children. Brand differences and packaging changes may contribute to differential risks with accidental exposure. We sought to identify high-risk features from SUDS... (Source: SafetyLit)
Source: SafetyLit - May 18, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Study links rheumatoid arthritis, Huntington's disease
Researchers have found a genetic link between rheumatoid arthritis and Huntington's disease, which shows promise of new treatment for both conditions. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 15, 2018 Category: Consumer Health News Source Type: news

Joint resolution: A link between Huntington's disease and rheumatoid arthritis
(University of California - San Diego) Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2018 Category: International Medicine & Public Health Source Type: news

Companies to use data in battle against Parkinson's, Alzheimer's, ALS
Morrisville-based contract research organization Worldwide Clinical Trials and Roivant-backed health care technology company Datavant are partnering to take on neurodegenerative diseases. Some of the most common neurodegenerative diseases include Parkinson's, Alzheimer's, Huntington's and amyotrophic lateral sclerosis, or ALS. According to Worldwide and Datavant, the most common neurodegenerative diseases cost the U.S. close to $800 billion annually.  Through the new partnership, Worldwide and… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 8, 2018 Category: American Health Authors: Jennifer Henderson Source Type: news

More Positive Results Released for Novel Huntington's Drug More Positive Results Released for Novel Huntington's Drug
The novel antisense oligonucleotide known as IONIS-HTTRx is safe and well tolerated and'has the potential to provide disease-modifying benefits'in Huntington's disease, say researchers.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 1, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Antisense Therapy Shows Promise in Huntington's
(MedPage Today) -- First human trial of huntingtin-lowering drug appears safe, well tolerated (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - April 25, 2018 Category: Neurology Source Type: news

In Huntington's disease, heart problems reflect broader effects of abnormal protein
(Children's Hospital of Philadelphia) Researchers investigating a key signaling protein in Huntington's disease describe deleterious effects on heart function, going beyond the disease's devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 24, 2018 Category: Biology Source Type: news

Dozens arrested in drug bust in Huntington, West Virginia
A federal prosecutor has announced a major drug trafficking bust in Huntington, West Virginia (Source: ABC News: Health)
Source: ABC News: Health - April 17, 2018 Category: Consumer Health News Tags: Health Source Type: news

Scientists find excess mitochondrial iron, Huntington's disease link
(University of Wyoming) The research identifying a pathway for Huntington's disease helps lay the foundation for developing drug therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2018 Category: International Medicine & Public Health Source Type: news

Perseveration and suicide in Huntington's disease - Roman OC, Stovall J, Claassen DO.
BACKGROUND: Huntington's disease (HD) patients are at significantly higher risk of suicidal behavior, and associated cognitive and behavioral factors play an important role. Impulsivity is commonly thought to be a risk factor, but does not completely accou... (Source: SafetyLit)
Source: SafetyLit - April 7, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

National equity investment will help firm expand 24-7 home-based doctor visits
The company, based in Huntington Beach, Calif., first entered the market in 2015 through a contract with BlueCross BlueShield of Western New York. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - April 6, 2018 Category: Biotechnology Authors: Tracey Drury Source Type: news

National equity investment will help firm expand 24-7 home-based doctor visits
The company, based in Huntington Beach, Calif., first entered the market in 2015 through a contract with BlueCross BlueShield of Western New York. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - April 6, 2018 Category: Health Management Authors: Tracey Drury Source Type: news

Landmark Health plans N.C. entrance through partnership with Blue Cross
Huntington Beach, Calif.-based Landmark Health is planning its entrance to the Tar Heel State through a new partnership with Blue Cross and Blue Shield of North Carolina. “We’re a risk-based provider group that cares for chronic, complex populations,” Jessica Diaz, senior director of brand and marketing at Landmark, said Thursday. “We partner with health plans and identify subsets of their population that really needs more care.” The new partnership with the Blue Cross of N.C. will see… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 30, 2018 Category: Biotechnology Authors: Jennifer Henderson Source Type: news

Landmark Health plans N.C. entrance through partnership with BCBSNC
Huntington Beach, California-based Landmark Health is planning its North Carolina entrance through a new partnership with Blue Cross and Blue Shield of North Carolina, Jessica Diaz, senior director of brand and marketing at Landmark, said Thursday. “We’re a risk-based provider group that cares for chronic, complex populations,” she says. “We partner with health plans and identify subsets of their population that really needs more care.” The new partnership with BCBSNC will see Landmark… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 30, 2018 Category: American Health Authors: Jennifer Henderson Source Type: news

Landmark Health plans N.C. entrance through partnership with BCBSNC
Huntington Beach, California-based Landmark Health is planning its North Carolina entrance through a new partnership with Blue Cross and Blue Shield of North Carolina, Jessica Diaz, senior director of brand and marketing at Landmark, said Thursday. “We’re a risk-based provider group that cares for chronic, complex populations,” she says. “We partner with health plans and identify subsets of their population that really needs more care.” The new partnership with BCBSNC will see Landmark… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 29, 2018 Category: Biotechnology Authors: Jennifer Henderson Source Type: news

C-Path and CHDI launch consortium to accelerate development of Huntington's therapies
(Critical Path Institute (C-Path)) C-Path and CHDI announce the launch of the Huntington's Disease Regulatory Science Consortium (HD-RSC) to advance innovation in regulatory science methods, drug development tools, and clearer regulatory pathways to accelerate the approval of HD therapeutics. HD-RSC will facilitate clinical data sharing and standardization, and the development of modeling tools, biomarkers, and clinical outcome assessments to help de-risk the drug-development pathway, potentially expedite regulatory review, and thereby incentivize drug developers to enter the HD sphere. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2018 Category: International Medicine & Public Health Source Type: news

New links between genetic abnormality and brain function in Huntington's disease
(Mary Ann Liebert, Inc./Genetic Engineering News) While the gene mutation that causes Huntington's disease has been associated with changes in certain types of functional brain connectivity, a new study that examined connectivity across the whole brain has now identified alterations in functional connectivity in additional brain networks and has also shown significant associations between the extent of the degree of gene mutation and measures of motor and cognitive function. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 21, 2018 Category: International Medicine & Public Health Source Type: news

Signaling pathway involving the Golgi apparatus identified in cells with Huntington's disease
(Johns Hopkins Medicine) Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by free radicals and oxidants. The research team showed that this pathway can be activated by a drug called monensin, which is commonly used as an antibiotic in animal feed. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 7, 2018 Category: International Medicine & Public Health Source Type: news

Fasting could be a cure for Huntington ’s disease
Scientists have discovered that fasting could be part of a future lifestyle cure for Huntington's disease, according to a new study, which was published by the University of British Columbia (Source: the Mail online | Health)
Source: the Mail online | Health - March 6, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Could fasting help to treat Huntington's disease?
Restricting food intake to a set time period every day could help to clear the brain of a protein that causes Huntington's disease, new research suggests. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 6, 2018 Category: Consumer Health News Tags: Huntington's Disease Source Type: news

Could fasting be a cure for Huntington ’s?
Scientists have discovered that fasting could be part of a future lifestyle cure for Huntington's disease, according to a new study, which was published by the University of British Columbia (Source: the Mail online | Health)
Source: the Mail online | Health - March 6, 2018 Category: Consumer Health News Source Type: news

Strict eating schedule can lower Huntington disease protein in mice
(University of British Columbia) New research from the University of British Columbia suggests that following a strict eating schedule can help clear away the protein responsible for Huntington disease in mice. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 6, 2018 Category: International Medicine & Public Health Source Type: news

Medical design and manufacturing challenges explored at ADM Cleveland
The challenges of medical manufacturing, from evolving quality system requirements to determining whether to outsource a technology or keep it in house, will be explored at free conference sessions during the upcoming Advanced Design & Manufacturing (ADM) Expo in Cleveland, OH. The trade show and conference comes to the Huntington Convention Center of Cleveland on March 7 and 8. A panel discussion on March 7 will dive into ISO 13485 certification, including the latest version of the international standard for medical device quality management systems. ISO 13485:2016 introduces a number of revisions that medical de...
Source: MDDI - February 26, 2018 Category: Medical Devices Authors: Norbert Sparrow Tags: Plastics Today Source Type: news

Decoding the structure of huntingtin
(Max-Planck-Gesellschaft) Determining the three dimensional structure of the protein could help to develop new treatments of Huntington's disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 22, 2018 Category: International Medicine & Public Health Source Type: news

Medical Design and Manufacturing Challenges to Be Explored at ADM Cleveland
The challenges of medical manufacturing, from evolving quality systems requirements to determining whether to outsource a technology or keep it in house, will be explored at free conference sessions during the upcoming Advanced Design & Manufacturing (ADM) Expo in Cleveland, OH. The trade show and conference comes to the Huntington Convention Center of Cleveland on March 7 and 8. A panel discussion on March 7 will dive into ISO 13485 certification, including the latest version of the international standard for medical device quality management systems. ISO 13485:2016 introduces a number of revisions that medical device...
Source: MDDI - February 21, 2018 Category: Medical Devices Tags: Plastics Today Source Type: news

Medical News Today: Huntington's 'super assassin' molecule could kill cancer
The gene that causes Huntington's disease is highly toxic to cancer cells, as revealed in tests on laboratory cells and mice with ovarian cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 13, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Huntington's disease provides new cancer weapon
(Northwestern University) Patients with Huntington's disease, a fatal genetic illness that causes the breakdown of nerve cells in the brain, have up to 80 percent less cancer than the general population. Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer, a new study reports. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2018 Category: Cancer & Oncology Source Type: news

Altering Huntington's patients' skin cells into brain cells sheds light on disease
(Washington University School of Medicine) Scientists at Washington University School of Medicine in St. Louis have transformed skin cells from patients with Huntington's disease into the type of brain cell affected by the disorder. The resulting mass of neurons serves as a new tool to study the degenerative and eventually fatal neurological condition, according to the researchers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 5, 2018 Category: International Medicine & Public Health Source Type: news

Uncovering the early origins of Huntington's disease
(Rockefeller University) The symptoms of Huntington's disease typically appear in middle age, but new research shows that neural abnormalities are evident much earlier, in the first steps of embryonic development. The findings suggest that treating the disease earlier may be beneficial. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 29, 2018 Category: International Medicine & Public Health Source Type: news

Should I find out?
Huntington's disease runs through Jackie Harrison's family, but should she take a test which will tell her if she will get it too? (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 23, 2018 Category: Consumer Health News Source Type: news

Researcher discovers commonalities in brains of people with HD and PD
(Boston University School of Medicine) A new study strongly suggests that the brains of people who have died of Huntington's disease (HD) and Parkinson's disease (PD) show a similar response to a lifetime of neurodegeneration, despite being two very distinct diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 12, 2018 Category: International Medicine & Public Health Source Type: news

Your body wants a schedule: Researchers find that eating at the same time every day helps fight cognitive decline
(Natural News) We’ve often been told that we shouldn’t skip meals, but did you know that following a regular eating schedule can help fight dementia? According to a study, “regular meals improve gene expression in the region of the brain associated with body control, which often degenerates in Huntington’s disease (HD); a form of dementia.” Simply... (Source: NaturalNews.com)
Source: NaturalNews.com - January 8, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Neurodegenerative disease: Restricting eating times may boost life quality
In a study of mouse models with Huntington's disease, researchers found that eating at the same time every day improved motor skills and sleep quality. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 3, 2018 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news

BU researchers identify possible biomarker for Huntington's disease
(Boston University School of Medicine) A new discovery of a potential biomarker for Huntington's disease (HD) could mean a more effective way of evaluating the effectiveness of treatments for this neurological disease. The findings may provide insight into treatments that could postpone the death of neurons in people who carry the HD gene mutation, but who do not yet show symptoms of the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 2, 2018 Category: International Medicine & Public Health Source Type: news

Terminally ill Hengoed parents fundraise for daughters
Dawn Wilson, 35, from Hengoed, South Wales, suffers from an incurable tumour while the father of her two daughters, has Huntington disease, a degenerative brain condition. (Source: the Mail online | Health)
Source: the Mail online | Health - December 27, 2017 Category: Consumer Health News Source Type: news

Suicidal ideation and suicidal behavior according to the C-SSRS in a European cohort of Huntington's disease gene expansion carriers - van Duijn E, Vrijmoeth EM, Giltay EJ, Bernhard Landwehrmeyer G.
BACKGROUND: Huntington's disease (HD) gene expansion carriers are at an increased risk of suicide, but so far, no studies have investigated the full spectrum of suicidality, including suicidal ideation, suicidal behavior and self-injurious behavior. ... (Source: SafetyLit)
Source: SafetyLit - December 21, 2017 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntingtons disease
Huntington’s disease (HD) is a neurodegenerative disease caused by an expansion in the huntingtin protein (also called Htt) that induces neuronal cell death with age. We found that the treatment of 12-month-old symptomatic heterozygous and homozygous zQ175 huntingtin knockin mice for 12 weeks with CTEP, a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), reduced the size and number of huntingtin aggregates, attenuated caspase-3 activity, and reduced both neuronal apoptosis and neuronal loss in brain tissue. Both motor and cognitive impairments were improved in CTEP-treated zQ175 mice. The r...
Source: Signal Transduction Knowledge Environment - December 19, 2017 Category: Science Authors: Abd-Elrahman, K. S., Hamilton, A., Hutchinson, S. R., Liu, F., Russell, R. C., Ferguson, S. S. G. Tags: STKE Research Articles Source Type: news

FDA to target homeopathic drugs that pose safety risks
The Food and Drug Administration proposed a tougher enforcement stance Monday toward homeopathic drugs, saying it would target products that pose the greatest safety risks, including those that contain potentially harmful ingredients or that are being marketed for serious diseases without proven benefits. Homeopathy is based on an 18th-century idea that substances that cause disease […]Related:He was a renowned surgeon — until a doctor found his initials burned on a patient’s liverA baby was born with her heart outside her body — and survived‘Phenomenal’ trial results may lead to a trea...
Source: Washington Post: To Your Health - December 18, 2017 Category: Consumer Health News Source Type: news

FDA takes more aggressive stance toward homeopathic drugs
The Food and Drug Administration on Monday proposed a tougher enforcement policy toward homeopathic drugs, saying it would target products posing the greatest safety risks, including those containing potentially harmful ingredients or being marketed for cancer, heart disease and opioid and alcohol addictions. Homeopathy is based on an 18th-century idea that substances that cause disease […]Related:He was a renowned surgeon — until a doctor found his initials burned on a patient’s liverA baby was born with her heart outside her body — and survived‘Phenomenal’ trial results may lead to a ...
Source: Washington Post: To Your Health - December 18, 2017 Category: Consumer Health News Source Type: news