Injection of vasoactive intestinal peptide into the eye improves corneal transplant survival
(Elsevier) A new study in The American Journal of Pathology reports for the first time that injection of neuropeptide vasoactive intestinal peptide (VIP) directly into the eye of mice enhanced corneal graft survival. VIP produced other benefits, including acceleration of endothelial wound closure, protection of corneal endothelial cells (CEnCs), and improved corneal graft clarity. If proven successful in clinical studies, this novel approach may help alleviate visual loss in many patients with corneal disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 7, 2018 Category: International Medicine & Public Health Source Type: news

3D-printed corneas could save millions ’ vision
Photo by Victor Freitas on Unsplash British scientists have 3D printed the first human corneas, yielding a potential fix to the worldwide shortage of corneas for implantation.  The Newcastle University researchers created a bio-ink using stem cells from a healthy donor cornea mixed with alginate and collagen. They used a simple, low-cost 3D bio-printer to extrude the bio-ink in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print. The proof-of-concept research was published in May in Experimental Eye Research. “Many teams across the world have been ...
Source: Mass Device - July 17, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: Biotech Blog Optical/Ophthalmic Research & Development Transplants Fight for Sight Newcastle University Source Type: news

First Use of Cadaver Nerves to Repair Corneal Anesthesia Shows Promise
Treatment TermsCorneal disease Overview A new, minimally invasive procedure that replaces damaged corneal nerves with a donor nerve restores feeling in the cornea and halts progressive eye damage caused by a condition known as corneal anesthesia. The use of the donor nerve, an advance pioneered at Duke, may help people recover faster after surgery and could impact how other chronic eye conditions are treated. Content Blocks Header What Is Corneal Anesthesia? ContentCorneal anesthesia -- the medical term is neurotrophic keratopathy -- is a potentially devastating condition that can arise after certain viral infections...
Source: dukehealth.org: Duke Health News - September 8, 2017 Category: Consumer Health News Authors: mf205 at duke.edu Source Type: news

Preventing graft rejection in high-risk corneal transplant patients
Treating donor corneas with a cocktail of molecules prior to transplanting to a host may improve survival of grafts and, thus, outcomes in high-risk corneal transplant patients, according to a new study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 1, 2017 Category: Science Source Type: news

New technique may prevent graft rejection in high-risk corneal transplant patients
(Massachusetts Eye and Ear Infirmary) Treating donor corneas with a cocktail of molecules prior to transplanting to a host may improve survival of grafts and, thus, outcomes in high-risk corneal transplant patients, according to a new study led by researchers at Massachusetts Eye and Ear. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 1, 2017 Category: Global & Universal Source Type: news

New keratoconus treatment may prevent need for corneal transplant
Treatment TermsCorneal disease Additional SEO Keywords cornea, corneal disease, keratoconus, keratoconus treatment, collagen cross-linking, corneal collagen cross-linking, corneal cross-linking, SEO Meta Description Corneal collagen cross-linking, an FDA-approved treatment for the eye disease keratoconus, can preserve vision and prevent the need for a corneal transplant. Author MaryAnn Fletcher Sub-Title Cross-linking procedure can halt corneal changes, preserve vision Overview Corneal collagen cross-linking, an FDA-approved treatment for the eye disease keratoconus, can preserve vision and prevent the need for a...
Source: dukehealth.org: Duke Health News - January 12, 2017 Category: Consumer Health News Authors: mf205 at duke.edu Source Type: news

New keratoconus treatment may prevent need for corneal transplant
Treatment TermsCorneal disease Additional SEO Keywords cornea, corneal disease, keratoconus, keratoconus treatment, collagen cross-linking, corneal collagen cross-linking, corneal cross-linking, SEO Meta Description Corneal collagen cross-linking, an FDA-approved treatment for the eye disease keratoconus, can preserve vision and prevent the need for a corneal transplant. Author MaryAnn Fletcher Sub-Title Cross-linking procedure can halt corneal changes, preserve vision Overview Corneal collagen cross-linking, an FDA-approved treatment for the eye disease keratoconus, can preserve vision and prevent the need for a...
Source: dukehealth.org: Duke Health News - January 12, 2017 Category: Consumer Health News Authors: mf205 at duke.edu Source Type: news

Does Diabetes Affect Corneal Transplant Suitability? Does Diabetes Affect Corneal Transplant Suitability?
Researchers have drawn different conclusions about the effect of diabetes on corneal endothelial cell count and donor eye suitability for transplant.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - January 5, 2017 Category: Transplant Surgery Tags: Diabetes & Endocrinology News Source Type: news

Early Cell Loss After Corneal Transplant Due to Eye Bank Miscount Early Cell Loss After Corneal Transplant Due to Eye Bank Miscount
Most very early cell loss after corneal transplant isn't due to surgical technique but to overestimated cell counts by eye banks, new research from France suggests.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - December 30, 2016 Category: Transplant Surgery Tags: Ophthalmology News Source Type: news

Pioneer in corneal surgery receives cornea society's highest honor
(University Hospitals Cleveland Medical Center) The Cornea Society has awarded Jonathan Lass, MD, the Castroviejo Medal, its highest honor. Dr. Lass, an ophthalmologist at University Hospitals Eye Institute at UH Cleveland Medical Center and Charles I Thomas Professor of Ophthalmology at Case Western Reserve University School of Medicine receives the award in recognition of his lifetime contributions to research and advancements in corneal transplant and surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 19, 2016 Category: Global & Universal Source Type: news

Alternative to Corneal Transplant for Keratoconus Promising Alternative to Corneal Transplant for Keratoconus Promising
New 5-year data show that Bowman layer transplantation is a safe and effective alternative to corneal transplantation for keratoconus, but experts caution that only a niche population will benefit.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 26, 2016 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

In corneal transplantation, men and women don't see eye to eye
(Wiley) A study of patients undergoing corneal transplants indicates that subtle differences between men and women may lead to poorer outcomes for a woman who has received a cornea from a male donor. The findings, which are published in the American Journal of Transplantation, suggest that gender matching may be beneficial to potentially reduce the risk of failure and rejection in patients undergoing corneal transplantation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2016 Category: Global & Universal Source Type: news

Simple procedure may prevent cornea transplant in common eye condition
Stephen FellerCHICAGO, July 13 (UPI) -- Removing a layer of cells in patients with a common eye disease can prevent the need for corneal transplant, according to researchers in Chicago. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 13, 2016 Category: Consumer Health News Source Type: news

New method could offer more precise treatment for corneal disease
Disease can cause the cornea, the clear dome-shaped layer that covers the front of the eye, to gradually weaken until pressure in the eye causes it to bulge and leads to vision problems. A corneal transplant may eventually be necessary as the condition, known as keratoconus, progresses. However, a new treatment called corneal crosslinking is showing promise for slowing or stopping the progression of keratoconus. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 4, 2016 Category: Science Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 14, 2016 Category: Science Source Type: news

Immunosuppressive medication effectively treats ocular graft-versus-host-disease
(Massachusetts Eye and Ear Infirmary) A complication associated with bone marrow transplantation, graft-versus-host-disease, occurs when a transplanted immune system attacks certain parts of a host's body, and may cause severe dry eye and damage to the cornea. A clinical trial at Massachusetts Eye and Ear showed that topical doses of ultra low-dose tacrolimus, an immunosuppressive medication, is equally effective and showed fewer hypertensive side effects in treating ocular symptoms associated with graft-versus-host-disease than methylprednisolone, a steroid medication. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 13, 2016 Category: Global & Universal Source Type: news

Nigeria: Restoration of Sight - Pledge Your Eyes Before Death, Nigerians Told
[Vanguard] WORRIED by the myriad of challenges confronting restoration of sight through corneal grafting also known as Keratoplasty, Nigerians have been urged to leave a legacy of sight by pledging their eyes before death. Making the call in Lagos, Consultant Ophthalmologist and Managing Director, the Eye Bank for Restoring Sight, Dr Mosunmade Faderin-Omotosho, said corneal blindness can be cured through corneal transplant by removing the damaged cornea and replacing it with a healthy one. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 16, 2016 Category: African Health Source Type: news

Ophthalmologists uncover autoimmune process that causes rejection of secondary corneal transplants
Ophthalmologists have identified an important cause of why secondary corneal transplants are rejected at triple the rate of first-time corneal transplants. The cornea -- the most frequently transplanted solid tissue -- has a first-time transplantation success rate of about 90 percent. But second corneal transplants undergo a rejection rate three times that of first transplants. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 17, 2015 Category: Science Source Type: news

Tiny nanoparticles could make big impact for patients in need of cornea transplant
There are about 48,000 corneal transplants done each year in the U.S., compared to approximately 16,000 kidney transplants and 2,100 heart transplants. Out of the 48,000 corneal transplants done, 10 percent of them end up in rejection, largely due to poor medication compliance. This costs the health care system and puts undue strain on clinicians, patients and their families. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 9, 2015 Category: Science Source Type: news

Tiny Nanoparticles Could Make Big Impact for Patients in Need of Cornea Transplant - 3/9/15
There are about 48,000 corneal transplants done each year in the U.S., compared to approximately 16,000 kidney transplants, according to the National Kidney Foundation, and 2,100 heart transplants, according to the U.S. Department of Health and Human Services' Organ Transplantation Network. (Source: Johns Hopkins Medicine News)
Source: Johns Hopkins Medicine News - March 9, 2015 Category: Research Source Type: news

Tiny nanoparticles could make big impact for patients in need of cornea transplant
(Johns Hopkins Medicine) There are about 48,000 corneal transplants done each year in the US, compared to approximately 16,000 kidney transplants and 2,100 heart transplants. Out of the 48,000 corneal transplants done, 10 percent of them end up in rejection, largely due to poor medication compliance. This costs the health care system and puts undue strain on clinicians, patients and their families. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2015 Category: Global & Universal Source Type: news

Wisdom teeth stem cells can transform into cells that could treat corneal scarring
Stem cells from the dental pulp of wisdom teeth can be coaxed to become cells of the eye's cornea and could one day be used to repair corneal scarring due to infection or injury, according to researchers. The findings indicate they also could become a new source of corneal transplant tissue made from the patient's own cells. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 23, 2015 Category: Science Source Type: news

Wisdom Teeth Stem Cells Could Treat Corneal Scarring
Stem cells from the dental pulp of wisdom teeth can be coaxed to turn into cells of the eye's cornea and could one day be used to repair corneal scarring due to infection or injury, according to researchers at the University of Pittsburgh School of Medicine. The findings, published online today in STEM CELLS Translational Medicine, indicate they also could become a new source of corneal transplant tissue made from the patient's own cells. (Source: Disabled World)
Source: Disabled World - February 23, 2015 Category: Disability Tags: Regenerative Medicine Source Type: news

Lab-grown corneas could prevent blindness
ConclusionThis study has identified that the cell surface protein Abcb5 is necessary for normal function of LSCs in renewing the cornea. It has also shown that LSCs can be separated out from other cells through the use of antibodies to the Abcb5 protein without causing damage to the LSCs. This means that it should be possible to gather these cells (in preference to other cells) and use them to provide the best chance for a successful corneal transplant.It is important to note that the mice were given genetically identical grafts or completely immunosuppressed so that they did not reject the grafts. At p...
Source: NHS News Feed - July 3, 2014 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news

Newer Corneal Transplant Techniques Linked to Worse OutcomesNewer Corneal Transplant Techniques Linked to Worse Outcomes
An Australian Corneal Graft Registry study has linked penetrating grafts to better survival and visual outcomes in keratoplasty compared with DALKs and endokeratoplasties. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 15, 2014 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Corneal Transplant: Does Donor Age Matter?Corneal Transplant: Does Donor Age Matter?
The 10-year results of the Cornea Donor Study answer important questions about the use of older donor tissue for penetrating keratoplasty. Medscape Ophthalmology (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - January 29, 2014 Category: Opthalmology Tags: Ophthalmology Viewpoint Source Type: news

New technique could boost corneal transplant acceptance rates
New research from the University of Texas Southwestern Medical Center at Dallas has detailed a new technique that may be able to boost patients' acceptance rates of corneal transplants. This is according to a study published in the American Journal of Transplantation.A corneal transplant, also referred to as a corneal graft, is an operation involving the removal of all or part of a damaged cornea. Using healthy corneal tissue from a suitable donor, the damaged cornea is replaced. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 3, 2014 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Study identifies potential new strategy to improve odds of corneal transplant acceptance
For the estimated 10 percent of patients whose bodies reject a corneal transplant, the odds of a second transplant succeeding are poor. All that could change, however, based on a UT Southwestern Medical Center study that has found a way to boost the corne (Source: UT Southwestern Medical Center News)
Source: UT Southwestern Medical Center News - December 31, 2013 Category: Hospital Management Source Type: news

Study identifies potential new strategy to improve odds of corneal transplant acceptance
(UT Southwestern Medical Center) For the estimated 10 percent of patients whose bodies reject a corneal transplant, the odds of a second transplant succeeding are poor. All that could change, however, based on a UT Southwestern Medical Center study that has found a way to boost the corneal transplant acceptance rate. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 30, 2013 Category: Global & Universal Source Type: news

DMEK Techniques Enhanced for Corneal TransplantDMEK Techniques Enhanced for Corneal Transplant
Surgeons are refining Descemet membrane endothelial keratoplasty (DMEK) to improve corneal transplant outcomes and make the procedure easier to perform. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 27, 2013 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

NIH-funded study finds donor age not a factor in most corneal transplants
Ten years after a transplant, a cornea from a 71-year-old donor is likely to remain as healthy as a cornea from a donor half that age, according to a study funded by the National Institutes of Health. Corneas from donors over age 71 perform slightly less well, but still remain healthy for the majority of transplant recipients after 10 years, the study found. (Source: News from NEI)
Source: News from NEI - November 15, 2013 Category: Opthalmology Source Type: news

NIH-funded study finds donor age not a factor in most corneal transplants
(NIH/National Eye Institute) Ten years after a transplant, a cornea from a 71-year-old donor is likely to remain as healthy as a cornea from a donor half that age, according to a study funded by the National Institutes of Health. Corneas from donors over age 71 perform slightly less well, but still remain healthy for the majority of transplant recipients after 10 years, the study found. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2013 Category: Global & Universal Source Type: news

Soccer Fans Put Their Hearts Into Organ Donor CampaignSoccer Fans Put Their Hearts Into Organ Donor Campaign
Not even death can sever fans' links with their beloved soccer team, promises a campaign to boost organ donations in Brazil which has helped to cut waiting lists for cornea and heart transplants to all-time lows. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 22, 2013 Category: Consumer Health News Tags: Transplantation News Source Type: news

Topical formulation identified for prolonged graft survival in corneal transplants
Argos Therapeutics Inc., a biopharmaceutical company focused on the development and commercialization of therapies that modulate the immune system to treat cancer, infectious diseases, transplant rejection, autoimmune and inflammatory diseases, has announced the publication of key findings on its soluble recombinant human CD83 protein (sCD83) in cornea transplants. The study, conducted in rodents, demonstrates that CD83 can modulate the immune system and promote graft survival... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 20, 2013 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Successful Corneal Transplant With Pre-Loaded Donor Tissue: A First For Massachusetts Eye And Ear
The first successful cornea transplant with donor endothelial tissue preloaded by an eye bank has been performed at Massachusetts Eye and Ear in Boston, Mass. Roberto Pineda II, M.D., Director of the Refractive Surgery Service at Mass. Eye and Ear, and an Associate Professor of Ophthalmology at Harvard Medical School, recently performed the groundbreaking transplant. Dr. Pineda performed the surgery utilizing donor endothelial tissue that was prepared and pre-loaded into EndoGlide™ (Angiotech Pharmaceuticals, Inc... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

First corneal transplant with pre-loaded donor tissue performed at Mass. Eye and Ear
(Massachusetts Eye and Ear Infirmary) The first successful cornea transplant with donor endothelial tissue preloaded by an eye bank has been performed at Massachusetts Eye and Ear in Boston, Mass. Roberto Pineda II, M.D., Director of the Refractive Surgery Service at Mass. Eye and Ear, and an associate professor of ophthalmology at Harvard Medical School, recently performed the groundbreaking transplant. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 7, 2013 Category: Global & Universal Source Type: news