Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
Conditions: Rare Diseases; Aniridia; Neurotrophic Keratopathy; Limbal Stem Cell Deficiency; Ocular Graft-versus-host Disease; Ocular Cicatricial Pemphigoid; EEC Syndrome; Corneal Neovascularization Sponsors: IRCCS Ospedale San Raffaele Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 14, 2024 Category: Research Source Type: clinical trials

UV light-mediated corneal crosslinking as (lymph)angioregressive pretreatment to promote graft survival after subsequent high-risk corneal transplantation (CrossCornealVision): protocol for a multicenter, randomized controlled trial
DiscussionBased on preclinical and early pilot clinical evidence, we want to test the novel concept of temporary (lymph)angioregressive pretreatment of high-risk eyes by CXL to promote subsequent corneal graft survival. So far, there is no evidence-based approach to reliably improve graft survival in the high-risk corneal transplantation setting available in clinical routine. If successful, this approach will be the first to promote graft survival in high-risk transplants. It will significantly improve vision and quality of life in patients suffering from corneal blindness.Trial registrationClinicalTrials.gov NCT05870566. ...
Source: Trials - March 6, 2024 Category: Research Source Type: clinical trials

Pathogenetic Risk Factors for Corneal Graft Rejection
Conditions: Graft Rejection Interventions: Procedure: penetrating keratoplasty Sponsors: The S.N. Fyodorov Eye Microsurgery State Institution Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials

Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
Conditions: Fuchs ' Endothelial Dystrophy; Corneal Edema Interventions: Procedure: PRGF Sponsors: Price Vision Group Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 15, 2024 Category: Research Source Type: clinical trials

A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
Conditions: Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique Sponsors: Tianjin Eye Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials

Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
Conditions: Platelet-rich Fibrin; Macular Holes; Pterygium; Glaucoma Interventions: Procedure: PRF membrane tamponade surgery in macular hole; Procedure: ILM peeling in macular hole; Procedure: PRF membrane grafting in pterygium; Procedure: Autologous conjunctival transplantation in pterygium; Procedure: autologous PRF membrane grafting in trabeculectomy for glaucoma; Procedure: Amniotic membrane in trabeculectomy for glaucoma; Procedure: PRF membrane grafting incorneal ulcer; Procedure: Amniotic membrane in corneal ulcer Sponsors: Lei Du Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials

Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease
Conditions: Corneal Disease; Endothelial Corneal Dystrophy; Corneal Transplant Failure; Corneal Transplant Rejection Interventions: Diagnostic Test: Optical Coherence Tomography Sponsors: Keratoplasty Alliance International Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

DMEK Endothelial Keratoplasty in Patients With a History of Anterior or Posterior Segment Surgery
Condition:   Patients Undergoing DMEK With a History of Anterior or Posterior Segment Surgery Intervention:   Procedure: Descemet Membrane Endothelial Keratoplasty Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 28, 2023 Category: Research Source Type: clinical trials