Fight Aging! Newsletter, August 3rd 2020

In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the ERK inhibitor U0126 and selective Ca2+-permeable AMPA receptor antagonist NASPM completely antagonized the effects of oxytocin. Long Term Low Dose Ethanol Intake Modestly Extends Life in Mice https://www.fightaging.org/archives/2020/07/long-term-low-dose-ethanol-intake-modestly-extends-life-in-mice/ As of the past few years, the long-standing debate over whether moderate alcohol intake has a protective effect on health had appeared to resolve to the conclusion that the observed epidemiology is explained by socioeconomic factors, not by the metabolic effects of molecules such as polyphenols present in wine or other alcoholic drinks. People who engage in more modest alcohol consumption tend to be in the wealthier sections of society, and thus are more health conscious, undertake lifestyle choices, and make better use of avai...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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When the Covid-19 pandemic began sweeping through Texas in mid-March, Texas Gov. Greg Abbott temporarily suspended hospitals from offering elective procedures in order to ensure more hospital space for suspected Covid-19 cases. Things seemed to return to normal as time went on, but he placed another temporary ban on the procedures in June as the second wave occurred. Now, as restrictions are lifting, St. Luke’s Health hospitals across the Greater Houston area are implementing new protocols to…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Yuan Zhang, Hui Jiang, Shengqian Dou, Bin Zhang, Xia Qi, Jing Li, Qingjun Zhou, Weina Li, Chen Chen, Qun Wang, Lixin Xie
Source: Life Sciences - Category: Biology Source Type: research
Travel between New Zealand and some states of Australia possible before end of the year;first virus death among asylum seekers in Greece; Follow the latest updatesGlobal deaths pass 996,000India passes 6m casesRegular ‘circuit breaker’ lockdowns ‘could help control Covid’Boris Johnson faces revolt over forcing through Covid measuresSee all our coronavirus coverage5.19amBSTIndias confirmed coronavirus tally reached 6 million cases on Monday, keeping the country second to the United States in number of reported cases since the pandemic began, AP reports.The Health Ministry on Monday reported 82,170 ne...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news UK news US news Science Infectious diseases Source Type: news
Publication date: Available online 6 August 2020Source: Advances in Chronic Kidney DiseaseAuthor(s): Caitlyn Vlasschaert, Joel Topf, Swapnil Hiremath
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
I was hoping to post this on the...forum that doesn't exist...but still awaiting access. If you don't feel comfortable posting a reply on the general forum I'd really appreciate a DM. Thanks in advance... So I have an offer to work with an ortho group and wonder if I can get some insight from all you wise folks on how to fairly counter what I think is a pretty poor offer... The good: Practice is in a part of town with an excellent payor mix. It's 3 orthos who have broken off from a... What do you all think of this offer to join an ortho group...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
wanted to see groups timeline from MBB to RFA after its decided that its axial pain requiring RFA- how you guys do the follow ups after the procedures? does it take 6-8 weeks to go from first MBB to final RFA
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
HEART attack symptoms include difficulty breathing, chest pain, and an overwhelming feeling of anxiety. But you could also be at risk of a deadly myocardial infarction and heart disease symptoms if you develop this sign on your skin. Has your skin changed colour?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Stromal interaction molecule 1 (STIM1) is the calcium sensor of the endo/sarcoplasmic reticulum (E/SR), essential to maintain calcium homeostasis. Together with ORAI1, a CRAC channels (calcium release activated channel), STIM1 participates in intracellular calcium stores replenishing through SOCE (store operated calcium entry). The luminal part senses ER intraluminal Ca2+ and the cytosolic part binds ORAI1. Genetic mutations in STIM1 gene have been described in different clinical conditions. Loss of function mutations have been described in patients presenting CRAC channelopathies.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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