A Push for Push Dose Epinephrine
You transport a 79-year-old woman to the hospital for fever and urinary incontinence. Her family mentions a history of frequent urinary tract infections. Her initial vital signs are a heart rate of 115 bpm, an oxygen saturation of 97% on room air, and a blood pressure of 105/75 mmHg. You establish a peripheral IV line and begin a bolus of normal saline. About 15 minutes away from the hospital, you note the patient becomes increasingly drowsy. Her heart rate has increased to 125 bpm and her blood pressure is now 85/47 mmHg. What are your next steps? Prehospital Shock Starting in 2018, push dose epinephrine replaced dopamine...
Source: JEMS Patient Care - March 14, 2019 Category: Emergency Medicine Authors: Sammy Hodroge, MD Tags: Training Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Source Type: news

IschemaView launches Rapid Angio neuroimaging system
Medical imaging dev IschemaView said yesterday that it launched its Rapid Angio neuroimaging system designed for use in the angiography suite. The Menlo Park, Calif.-based company said that it partnered with Siemens (NYSE:SI) to integrate the Rapid software with Siemens’ SyngoDynaCT multiphase system for the newly launched imaging solution. Siemens’ SyngoDyna CT Multiphase is a 3D image acquisition technique which uses multiple rotations of a C-arm system to acquire multi-phasic 3D representation of the brain and its perfusion. “The Rapid Angio module, by combining the best-in-class sy...
Source: Mass Device - March 1, 2019 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Imaging Neurological ischemaview Source Type: news

EMS Medical Directors Chart the Future of EMS at Annual Gathering of Eagles
The Metropolitan Medical Directors Coalition (AKA “Eagles”) 21st Annual Retreat (AKA “Eagle Creek”) was held Wednesday and Thursday, February 27 and 28, at the Dallas Sheraton Hotel under the leadership of Paul Pepe, MD. The closed, invitation-only retreat is attended by 70 medical directors from the most-populated metropolitan EMS systems as well as 18 EMS fellows—33% of the nation’s current EMS fellows. This group oversees EMS for a combined population of over 114 million people in the United States and abroad, with representatives from Canada; Germany; New Zealand; Italy; Amsterdam, T...
Source: JEMS Patient Care - February 28, 2019 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT P Tags: Top Story News Exclusive Articles Patient Care Administration and Leadership Operations Source Type: news

EMS Medical Directors Chart the Future of EMS at Annual Gathering of Eagles
The Metropolitan Medical Directors Coalition (AKA “Eagles”) 21st Annual Retreat (AKA “Eagle Creek”) was held Wednesday and Thursday, February 27 and 28, at the Dallas Sheraton Hotel under the leadership of Paul Pepe, MD. The closed, invitation-only retreat is attended by 70 medical directors from the most-populated metropolitan EMS systems as well as 18 EMS fellows—33% of the nation’s current EMS fellows. This group oversees EMS for a combined population of over 114 million people in the United States and abroad, with representatives from Canada; Germany; New Zealand; Italy; Amsterdam, T...
Source: JEMS Administration and Leadership - February 28, 2019 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT P Tags: Top Story News Exclusive Articles Patient Care Administration and Leadership Operations Source Type: news

EMS Medical Directors Chart the Future of EMS at Annual Gathering of Eagles
The Metropolitan Medical Directors Coalition (AKA “Eagles”) 21st Annual Retreat (AKA “Eagle Creek”) was held Wednesday and Thursday, February 27 and 28, at the Dallas Sheraton Hotel under the leadership of Paul Pepe, MD. The closed, invitation-only retreat is attended by 70 medical directors from the most-populated metropolitan EMS systems as well as 18 EMS fellows—33% of the nation’s current EMS fellows. This group oversees EMS for a combined population of over 114 million people in the United States and abroad, with representatives from Canada; Germany; New Zealand; Italy; Amsterdam, T...
Source: JEMS: Journal of Emergency Medical Services News - February 28, 2019 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT P Tags: Top Story News Exclusive Articles Patient Care Administration and Leadership Operations Source Type: news

EMS Medical Directors Chart the Future of EMS at Annual Gathering of Eagles
The Metropolitan Medical Directors Coalition (AKA “Eagles”) 21st Annual Retreat (AKA “Eagle Creek”) was held Wednesday and Thursday, February 27 and 28, at the Dallas Sheraton Hotel under the leadership of Paul Pepe, MD. The closed, invitation-only retreat is attended by 70 medical directors from the most-populated metropolitan EMS systems as well as 18 EMS fellows—33% of the nation’s current EMS fellows. This group oversees EMS for a combined population of over 114 million people in the United States and abroad, with representatives from Canada; Germany; New Zealand; Italy; Amsterdam, T...
Source: JEMS Operations - February 28, 2019 Category: Emergency Medicine Authors: A.J. Heightman, MPA, EMT P Tags: Top Story News Exclusive Articles Patient Care Administration and Leadership Operations Source Type: news

Palm Beach County Sees Results After Instituting a Bundle of Care Approach to Resuscitation
Palm Beach County, Florida, is home to 1.4 million residents and is host to many more visitors each year as a major tourist destination. It’s a sprawling, multicultural and diverse socioeconomic demographic with extremes of age. In 2015, based upon disappointing resuscitation rates, the bundle of care approach was instituted by the county’s new EMS medical directors. Within three months, resuscitation rates improved dramatically, and in the ensuing years, have remained at over double their prior level. How did this occur, and what are the implications for enhancing cardiac arrest survival across other jurisdict...
Source: JEMS Patient Care - February 27, 2019 Category: Emergency Medicine Authors: Kenneth A. Scheppke, MD Tags: Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Heart of America Source Type: news

Active Intrathoracic Pressure Regulation During Resuscitation
Active intrathoracic pressure regulation (aIPR) is a novel therapy approved for the treatment of low blood flow states, such as cardiac arrest. This therapy is delivered with a device called the CirQPOD that’s inserted into a standard respiratory circuit between the patient and a means to provide positive pressure ventilation (e.g., bag-valve balloon or mechanical ventilator). Between each positive pressure ventilation, aIPR decrease intrathoracic pressure to subatmospheric levels, which subsequently enhances blood return to the heart and increases stoke volume, cardiac output, arterial blood pressures and coronary p...
Source: JEMS Patient Care - February 27, 2019 Category: Emergency Medicine Authors: Nicolas Segal, MD, PhD Tags: Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Heart of America Source Type: news

Minnesota Resuscitation Consortium Advanced Perfusion & Reperfusion Cardiac Life Support Strategy for Out-of-Hospital Refractory V Fib
Approximately 400,000 people in the United States suffer out-of-hospital cardiac arrest (OHCA) each year. One-third present to EMS with a shockable rhythm (v fib/v tach). Of these patients with an initial shockable rhythm, 50% are refractory to treatment resulting in prolonged duration of resuscitation and poor outcomes.1,2 The Minnesota Resuscitation Consortium (MRC) initiated the Advanced Perfusion and Reperfusion Cardiac Life Support Strategy for Out-of-Hospital Refractory Ventricular Fibrillation (v fib) in December 2015, in an effort to improve survival outcomes for patients suffering refractory v fib arrest. Extracor...
Source: JEMS Patient Care - February 27, 2019 Category: Emergency Medicine Authors: Jason Bartos, MD, PhD Tags: Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Heart of America Source Type: news

REBOA and SAAP: Aortic Interventions for Resuscitation
REBOA Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) involves the use of an aortic balloon catheter to limit blood loss caudal to the inflated balloon in patients with severe, uncontrolled truncal and junctional hemorrhage. Initially described during the Korean War, aortic balloon occlusion for hemorrhage control in trauma was reported sporadically over the ensuing decades without general adoption into clinical practice. This has changed in the past decade in response to injury patterns observed in the combat theaters of the Middle East. Preclinical studies in U.S. military research labs characterized th...
Source: JEMS Patient Care - February 27, 2019 Category: Emergency Medicine Authors: James E. Manning, MD Tags: Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Heart of America Source Type: news

Indocyanine Green Laser Angiography in Tumescence Indocyanine Green Laser Angiography in Tumescence
What benefits might indocyanine green laser angiography offer in the assessment of tissue perfusion during breast surgery?ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 22, 2019 Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news

Alternate Resuscitation Target Does Not Cut Sepsis Mortality Alternate Resuscitation Target Does Not Cut Sepsis Mortality
A peripheral perfusion resuscitation strategy was not superior to the standard lactate-level testing currently used in patients with early septic shock in the five-country ANDROMEDA-SHOCK trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 19, 2019 Category: Consumer Health News Tags: Critical Care News Source Type: news

Children with severe traumatic brain injury, intracranial pressure, cerebral perfusion pressure, what does it mean? A review of the literature - Lovett ME, O'Brien NF, Leonard JR.
Severe traumatic brain injury is a leading cause of morbidity and mortality in children. In 2003 the Brain Trauma Foundation released guidelines that have since been updated (2010) and have helped standardize and improve care. One area of care that remains... (Source: SafetyLit)
Source: SafetyLit - February 18, 2019 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Head-Up CPR May Improve Neurologically Intact Survival Rates
Head-up CPR is a novel concept in resuscitation that has the potential to improve neurologically intact survival after cardiac arrest. Inspired by the clinical question of whether patients in cardiac arrest should be transported either head-up or feet-up in a small elevator, an initial animal study was performed in 2014. In this swine model of cardiac arrest, pigs underwent five-minute periods of automated CPR with an impedance threshold device (ITD-16) in the traditional supine position, then with a 30-degree whole-body head-up tilt, and then a 30-degree whole-body head-down tilt. The cerebral blood flow and cerebral perf...
Source: JEMS Patient Care - February 15, 2019 Category: Emergency Medicine Authors: Johanna C. Moore, MD, MS Tags: Cardiac & Resuscitation Top Story Exclusive Articles Patient Care Heart of America Source Type: news

EXTEND: More Evidence of tPA Benefit 9 Hours After Stroke EXTEND: More Evidence of tPA Benefit 9 Hours After Stroke
Past research showed MRI imaging can identify patients best suited for therapy; new results now show that CT perfusion imaging also works for patient selection.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 13, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Size and time impact outcomes when mechanical clot removal used for large core strokes
(American Heart Association) Patient outcomes with large core stroke damage are worse the larger the core volume and the longer the time lapse between stroke onset and treatment. Perfusion imaging may help identify large core stroke patients who are potential candidates for mechanical thrombectomy (clot removal). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 7, 2019 Category: International Medicine & Public Health Source Type: news

CT matches MRI for late-window stroke evaluation
Stroke patients who underwent endovascular therapy had similar improvement...Read more on AuntMinnie.comRelated Reading: Machine learning can predict stroke treatment outcomes Study reveals steep cost of delaying stroke treatment 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment CTA helps direct use of clot removal for stroke patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 6, 2019 Category: Radiology Source Type: news

Neovasc touts Reducer study
Neovasc (NSDQ:NVCN) this week touted a newly-published article that described the use of dipyridamole stress perfusion cardiac magnetic resonance to evaluate its Reducer device. The Vancouver-based company’s device is designed to treat refractory angina. The article, published in the Journal of the American College of Cardiology: Cardiovascular Interventions, featured a 66 year old man with angina who was treated with anti-ischemic therapy. Four months after being implanted with the Reducer, the patient was asymptomatic for angina and reported improved quality of life, according to Neovasc. A four-month dip...
Source: Mass Device - January 24, 2019 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Featured Vascular neovasc Source Type: news

RFPi wins FDA nod for non-contact blood flow imaging tech
RFPi’s iCertainty shows images of blood flow and perfusion without contact with the patient. FDA has cleared RFPi’s iCertainty real-time, noninvasive blood flow and perfusion imaging medical device for use during surgical procedures, the company said. iCertainty is the first medical imaging device to show blood flow without interrupting a surgical procedure or requiring injections, dyes, radiation or direct patient contact, according to the Greenville, N.C. company. Use of iCertainty during surgery could reduce procedural complications or repeat surgeries, reduce hospital costs, and obj...
Source: Mass Device - January 16, 2019 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Blood Management Business/Financial News Food & Drug Administration (FDA) Imaging News Well Research & Development RFPi Source Type: news

Liver transplant 'game changing' treatment approved
It's hoped perfusion machines that "warm livers" will increase the number of viable donated organs. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 16, 2019 Category: Consumer Health News Source Type: news

Perfusion technique could boost number of viable donor livers
Slows rate of tissue deterioration and lengthens storage time, says NICE Related items fromOnMedica Primary sclerosing cholangitis New drive launched to trace hepatitis C patients Hepatocellular carcinoma risk, cirrhosis and hepatitis C Deaths from hepatitis C drop 11% in past year Alcohol consumption in late teens can predict risk of liver problems later (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 16, 2019 Category: UK Health Source Type: news

IschemaView wins expanded FDA nod for Rapid neuroimager
Medical imaging dev IschemaView said today that it won expanded FDA clearance for its Rapid neuroimaging platform intended for use in selecting patients likely to benefit from endovascular thrombectomy. With the clearance, the Menlo Park, Calif.-based company said that its Rapid CT-Perfusion and Rapid MR-Perfusion devices can now be used to aid in selecting acute stroke patients with known occlusions of the internal carotid artery or proximal middle cerebral artery for a clot removal procedure. IschemaView touted its Rapid system as the only imaging platform approved for selecting stroke patients for clot removal. “T...
Source: Mass Device - January 15, 2019 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Imaging Neurological Regulatory/Compliance ischemaview Source Type: news

iSchemaView wins new FDA clearance for Rapid platform
Cerebrovascular imaging software developer iSchemaView has received an additional...Read more on AuntMinnie.comRelated Reading: iSchemaView reports rapid sales growth iSchemaView lands FDA nod for CTA software Perfusion imaging expands window for stroke treatment (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 15, 2019 Category: Radiology Source Type: news

Start-up BURL develops ultrasound-based 'ECG for stroke'
SAN FRANCISCO - A California start-up is developing an ultrasound-based device...Read more on AuntMinnie.comRelated Reading: Study reveals steep cost of delaying stroke treatment 3 CTA signs show which stroke patients can skip surgery 5 risk factors help predict brain hemorrhage on CT AI algorithm can triage head CT exams for urgent review Perfusion imaging expands window for stroke treatment (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 9, 2019 Category: Radiology Source Type: news

Temporal neurophysiological dynamics in traumatic brain injury - the role of pressure reactivity and optimal cerebral perfusion pressure for predicting outcome - Svedung Wettervik TM, Howells T, Enblad P, Lew én A.
Intracranial pressure (ICP), cerebral perfusion pressure (CPP) and the pressure reactivity index (PRx) have been shown to correlate with outcome after traumatic brain injury (TBI), but their temporal evolution is less studied. Optimal CPP (CPPopt), i.e. th... (Source: SafetyLit)
Source: SafetyLit - January 3, 2019 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Early Administration of Intravenous Fluids in Sepsis: Pros and Cons.
Fluid resuscitation in the management of patients with sepsis and severe sepsis has been considered the standard of care for almost 2 decades. The rationale for fluid resuscitation is related to improvement in cardiac output and organ perfusion. Recent research evidence challenges the use of fluid resuscitation in patients diagnosed with sepsis. Research is needed to determine the timing of fluid administration, as well as the volume and type of fluid to achieve positive patient outcomes. This journal article discusses the pros and cons of early fluid administration in the management of patients with sepsis. (Source: Curre...
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

Fertility Tracker Guarantees Pregnancy Within One Year
Until recently, detecting the time during a woman’s cycle when she is most likely to conceive has been imprecise. Methods included measuring basal temperature spikes, which only detect ovulation after the fact, or urine tests that indicate a surge in luteinizing hormone, which predict ovulation is imminent within 12-36 hours. Both require meticulous recording of data by the user. Ava Science offers a fertility tracker that requires much less effort on the part of the user. Ava, a device that is worn on the wrist like a bracelet while the woman is sleeping, measures key physiological parameters to detect s...
Source: MDDI - December 14, 2018 Category: Medical Devices Authors: Susan Shepard Tags: Digital Health Source Type: news

FDA grants breakthrough status to joint Merck-Bayer AI program
Merck and Bayer have been granted FDA Breakthrough Device Designation for the collaborative Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Artificial Intelligence Pattern Recognition software. CTEPH can be difficult to diagnose because its symptoms are similar to asthma and chronic obstructive pulmonary disease symptoms. CTEPH affects five people per million annually worldwide. Computed tomography pulmonary angiography and a ventilation/perfusion scan can be used to determine if thromboembolic occlusion is causing pulmonary hypertension in patients. Get the full story on our sister site, Medical Design & Outsour...
Source: Mass Device - December 10, 2018 Category: Medical Devices Authors: Danielle Kirsh Tags: Food & Drug Administration (FDA) Bayer Merck Source Type: news

' De-Fatting' Tx May Give Discarded Livers New Life
(MedPage Today) -- Ex vivo perfusion system plus therapy reduced fat in steatotic livers (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - November 11, 2018 Category: Gastroenterology Source Type: news

FDA grants de novo clearance to AI Biomed, FluoOptics parathyroid tissue detection devices
The FDA today granted de novo clearance to parathyroid tissue detection devices from both Fluoptics and AI Biomed. The systems are intended to provide the real-time location of parathyroid tissue during surgical procedures including thyroidectomy and parathyroidectomy, the federal watchdog said. FluOptics won approval for its Fluobeam 800 clinic imaging device which can be used as a companion to assist in locating parathyroid tissue during surgery, the FDA said. Parathyroid tissue emits a fluorescent glow when exposed to the Fluobeam’s light source, which eliminates the need for a contrast agent. The system previousl...
Source: Mass Device - November 6, 2018 Category: Medical Devices Authors: Fink Densford Tags: Imaging Regulatory/Compliance Surgical aibiomed Fluoptics Source Type: news

FDA warns of battery shutdown issues with Getinge ’ s Maquet/Datascope IABPs
The FDA this week posted a letter to healthcare providers warning of reports that Getinge‘s (PINK:GETI B) Datascope and Maquet  intra-aortic balloon pumps are shutting down while running on battery power, which could result in serious injury or death. The company’s intra-aortic balloon pump is designed to be implanted in the descending aorta distal to the left subclavian artery. The system is intended to provide temporary support to the heart’s left ventricle using an electromechanical system to inflate and deflate the balloon, increasing coronary perfusion and reducing left ventricula...
Source: Mass Device - November 2, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Assist Devices Cardiovascular Featured Food & Drug Administration (FDA) Datascope Corp. Getinge Maquet Cardiovascular LLC Source Type: news

Masimo Q3 beats The Street
Masimo (NSDQ:MASI) today released third quarter earnings that topped expectations on Wall Street and lifted its guidance for the remaining year. The Irvine, Calif.-based company posted profits of $57.1 million, or $1.02 per share, on sales of $210.6 million for the three months ended September 29, for bottom-line growth of 59.3% on sales growth of 8.9% compared with the same period last year. Adjusted to exclude one-time items, earnings per share were 71¢, ahead of the 69¢ consensus on The Street, where analysts were looking for sales of $207.6 million, which the company also topped. “We are happy to r...
Source: Mass Device - October 31, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News MassDevice Earnings Roundup Wall Street Beat Masimo Source Type: news

Masimo wins FDA nod for improved RD SET sensors
Masimo (NSDQ:MASI) said today it won FDA 510(k) clearance for its RD SET sensors with measure-through motion and low perfusion SET pulse oximetry. The newly cleared sensors feature improved SpO2 accuracy specifications for patients under 3kg, the Irvine, Calif.-based company said, and are designed to improve accuracy, patient comfort and clinician workflows. “We’re delighted to be able to announce our continued innovation in our foundational SET pulse oximetry. Thanks to the brilliance and dedication of our engineers and the continuing support of our customers, we’ve been able to once again rais...
Source: Mass Device - October 25, 2018 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Diagnostics Food & Drug Administration (FDA) Regulatory/Compliance Masimo Source Type: news

Ditch the Machine to Improve Accuracy in Blood Pressure Measurement and Diagnostics
Conclusion For the patient in this case, the decision to forego the convenience of a machine in favor of the skills of a knowledgeable paramedic was lifesaving. Much like the comparison often drawn between the old-fashioned barbell and more sophisticated exercise machines, newer, more complex, and more expensive might make a process more comfortable, but doesn’t always equate to superior results. As we surrender more and more of our hands-on skills to the ease of automated technology, we risk more than the loss of the aptitudes that form the foundation of sound patient assessment—we place our patients in jeopar...
Source: JEMS Special Topics - October 24, 2018 Category: Emergency Medicine Authors: Mark Rock, NRP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Study reveals steep cost of delaying stroke treatment
Researchers from Canada have found that delaying treatment for stroke patients...Read more on AuntMinnie.comRelated Reading: 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment Infervision debuts AI stroke screening software CTA helps direct use of clot removal for stroke patients Color mapping boosts vessel interpretation in stroke CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 18, 2018 Category: Radiology Source Type: news

Variabilities in the Use of IV Epinephrine in the Management of Cardiac Arrest Patients
Animal studies in the 1960s first demonstrated the benefits of using epinephrine alongside external compressions and external shock to achieve return of spontaneous circulation (ROSC) in arrested and asphyxiated dogs.1–4 Since then, epinephrine has become integral to the performance of advanced cardiac life support (ACLS) care. The American Heart Association’s (AHA) recommendations in the Emergency Cardiovascular Care (ECC) Guidelines are that a standard dose of 1 mg of 1:10,000 epinephrine every 3–5 minutes “may be reasonable for patients with cardiac arrest.”5 No maximum total dose is deline...
Source: JEMS Patient Care - October 15, 2018 Category: Emergency Medicine Authors: Nidhish Lokesh, NREMT Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Variabilities in the Use of IV Epinephrine in the Management of Cardiac Arrest Patients
Discussion The results show a lack of standardization in epinephrine dosing across large EMS systems around the world, in spite of the existence of standard guidelines such as the 2015 AHA CPR and ECC Guidelines.5 Dosing maximums, epinephrine drip use, dosing amount and frequency, and dosing distinction for rhythms not being more consistent across the board shows the current state of uncertainty that epinephrine administration is in at this time. The AHA ECC Guidelines don’t specify dosing maximums or about distinguish between v fib and other rhythms.5 In those two categories, responding agencies showed a lack of sta...
Source: JEMS Special Topics - October 15, 2018 Category: Emergency Medicine Authors: Nidhish Lokesh, NREMT Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Neuromics New Neuronal Markers
Best of the BestWe are recognized for having some of the bestNeuronal-Glial Antibodies in the business. We are pleased to announce the addition of these:CH22122– Tyrosine HydroxylaseGT22101 - GFPGT22102– MAP2GT22103 - VimentinMO22186– Tyrosine HydroxylaseRA22135– Tyrosine HydroxylaseImmunofluorescent analysis of rat brainstem section stained withGT22102, MAP2dilution 1:2,000 in red, and costained with mouse mAb to MO22121, MBP dilution 1:5,000, in green. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was postfixed for 24 hours, cut to 45 μM, and free-floating sections wer...
Source: Neuromics - October 7, 2018 Category: Neuroscience Tags: Immunofluorescence MAP2 antibody MBP Antibody Myelin Basic Protein TH antibody Tyrosine Hydroxlase antibody Western Blotting Source Type: news

NeoVasc shares jump on 12-week Reducer data
Neovasc (NSDQ:NVCN) today saw shares jump after it released 12-week data from the first patient implanted with its Reducer device designed for treating refractory angina. The Reducer system is designed to alter blood flow in the heart’s circulatory system to increase perfusion of oxygenated blood to ischemic areas of heart muscle, and can be placed in a minimally invasive transvenous procedure, the Vancouver-based company said. The patient, implanted with the device in June as part of a compassionate use case, reported the ability to walk several miles without symptoms after having not been able to walk two bloc...
Source: Mass Device - October 3, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Neovasc Inc. Source Type: news

The LKB1-AMPK-{alpha}1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The unique sensitivity of these muscles to hypoxia is conferred by mitochondrial cytochrome c oxidase subunit 4 isoform 2, the inhibition of which has been proposed to trigger HPV through increased generation of mitochondrial reactive oxygen species. Contrary to this model, we have shown that the LKB1–AMPK-α1 signaling pathway is critical to HPV. Spectral Doppler ultrasound revealed that deletion of the AMPK-α1 catalytic subunit blocke...
Source: Signal Transduction Knowledge Environment - October 2, 2018 Category: Science Authors: Moral-Sanz, J., Lewis, S. A., MacMillan, S., Ross, F. A., Thomson, A., Viollet, B., Foretz, M., Moran, C., Hardie, D. G., Evans, A. M. Tags: STKE Research Articles Source Type: news

Airway, Breathing or Consequences: Use Your Tools and Trust the Technology
“An esophageal intubation is no sin, but there is great sin in not recognizing such a placement.” — Special Operations Combat Medical Skills Sustainment Course (U.S. Special Operations Command) How hard is it take to properly intubate the trachea? Actually, it’s far more difficult than most people think. Recent anesthesia research shows that at least 75 live adult intubations are needed to achieve a 90% initial competency.1 Yes, 75! Not the very limited live number that are experienced in many paramedic schools, and certainly not only practicing with manikins. And how hard is it to intubate the esop...
Source: JEMS Special Topics - October 2, 2018 Category: Emergency Medicine Authors: Scott DeBoer, RN, MSN, CEN, CPEN, CCRN, CFRN, EMT-P Tags: Airway & Respiratory Exclusive Articles Source Type: news

What is the Blood Culture Recovery Rate After Antibiotic Pretreatment?
Discussion Sepsis is an inflammatory response syndrome in the presence of an infection, it can be caused by bacteria, viruses or fungi. Bacteremia is the presence of bacteria in the blood. Studies from the US show an increased incidence of sepsis (0.56 to 0.89 cases/1000 children in all age groups) but a decreased fatality rate from 10.3% to 8.9%. The prevalence of severe sepsis in pediatric intensive care settings is reported in as many as 7.7% of admissions. Severe sepsis is more common when patients have co-morbities. Primary prevention includes immunization and appropriate precautions and procedures (i.e. catheter acce...
Source: PediatricEducation.org - October 1, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Using Imaging to Select for Late Window Endovascular Therapy Using Imaging to Select for Late Window Endovascular Therapy
After acute stroke, MRI and computed tomography perfusion may be useful for selecting appropriate candidates for late window thrombectomy.Stroke (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 24, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

A Change of Heart: Perspectives on Patient Care and Technology
Bryon Moore has had a rich and varied career in EMS. He became an EMT in 1979 and received paramedic training at the fabled UCLA Daniel Freeman School for Paramedicine in 1982. He went on to be a paramedic in several systems before becoming the Northern California Clinical Coordinator for American Medical Response (AMR). Bryon then was attracted to helping develop and bring new resuscitation technology to market, working for a variety of medical device companies and launching new products globally. He’s currently VP of EMS Market Development for Defibtech, a company owned by Nihon Kohden, a leading medical devic...
Source: JEMS Special Topics - September 19, 2018 Category: Emergency Medicine Authors: JEMS Staff Tags: EMS Insider Exclusive Articles Administration and Leadership Source Type: news

3 CTA signs show which stroke patients can skip surgery
There are three key characteristics evident on CT angiography (CTA) scans that...Read more on AuntMinnie.comRelated Reading: 5 risk factors help predict brain hemorrhage on CT AI algorithm can triage head CT exams for urgent review Perfusion imaging expands window for stroke treatment CTA helps direct use of clot removal for stroke patients Color mapping boosts vessel interpretation in stroke CT (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 13, 2018 Category: Radiology Source Type: news

Cerebral hemodynamics after transcranial direct current stimulation (tDCS) in patients with consequences of traumatic brain injury - Trofimov AO, Kalentiev G, Karelsky M, Ksenofontova C, Ruzavina A, Yuriev M, Bragin DE.
In recent years, hopes for better treatment of traumatic brain injury (TBI) have focused on non-pharmacologic transcranial electrical brain stimulation; however, studies of perfusion changes after stimulation are few and contradictory. Therefore, the aim o... (Source: SafetyLit)
Source: SafetyLit - September 6, 2018 Category: International Medicine & Public Health Tags: TBI Source Type: news

Miracor Medical closes $35m Series D
Miracor Medical Systems said today it raised $34.6 million (EU €30 million) Series D round of financing to help support the development and commercialization of its PiCSO Impulse System. The round was led by Ming Capital and co-led by a strategic investor, the Belgium-based company said. The round was also joined by newly invested Belgian investment fund Quest for Growth and existing investors Ming Capital, SFPI and Meusinvest. The company’s PiCSO therapy is designed to be used during stenting procedures for patients affected by acute myocardial infarcts to improve pressure in the coronary venous system to impro...
Source: Mass Device - September 4, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Cardiovascular Funding Roundup Miracor Source Type: news

Philips acquires pulse oximetry sensor maker Xhale Assurance
Royal Philips (NYSE:PHG) said this week it acquired pulse oximetry sensor maker Xhale Assurance for an undisclosed amount. Xhale Assurance produces a disposable pulse oximetry sensor designed to be placed on the wing of the nose to monitor heart rate and blood oxygenation under low perfusion conditions, which Amsterdam-based Philips said can be challenging with conventional fingertip sensors. Philips said that the acquisition will differentiate its existing oxygen saturation monitoring solutions protfolio and allow it to expand into an underserved clinical segment. “Xhale Assurance’s nasal alar sensor offe...
Source: Mass Device - August 31, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Diagnostics Mergers & Acquisitions royalphilips Source Type: news

CT finds heart disease in patients with lung cancer
Assessing coronary artery disease on the CT scans of patients with lung cancer...Read more on AuntMinnie.comRelated Reading: AI, new cardiac imaging technology can assess for CAD CCTA biomarker spots high-risk plaques in heart disease Cardiac hybrid imaging predicts adverse cardiac events CCTA reduces unnecessary invasive coronary procedures Is CT or MR perfusion better for diagnosing CAD? (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 27, 2018 Category: Radiology Source Type: news

5 risk factors help predict brain hemorrhage on CT
U.K. researchers have identified five factors -- including contrast leakage...Read more on AuntMinnie.comRelated Reading: Could a blood test rule out most CT for brain injury? Perfusion imaging expands window for stroke treatment Color mapping boosts vessel interpretation in stroke CT More than one-third of emergency head CTs unnecessary Head CT algorithm a step toward faster stroke care (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 17, 2018 Category: Radiology Source Type: news