Chest pain, and Cardiology didn't take the hint from the ICD
Submitted and written by Megan Lieb, DO with edits by Bracey, Smith, Meyers, and GrauerA 50-ish year old man with ICD presented to the emergency department with substernal chest pain for 3 hours prior to arrival. The screening physician ordered an EKG and noted his ashen appearance and moderate distress. Triage EKG:What do you think?Triage physician interpretation: -sinus bradycardia-lateral ST depressionsWhile there are lateral ST depressions (V5, V6) the deepest ST depressions are in V4. Additionally, lead V3 has ST depressions, which are always abnormal (recall that lead V3 will haveST elevation under nor...
Source: Dr. Smith's ECG Blog - January 23, 2023 Category: Cardiology Authors: Bracey Source Type: blogs

Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging. Association of LDL-Cholesterol with Mortality https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/ Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inflammatory cGAS-STING Signaling in Age-Related Endothelial Dysfunction
Chronic, unresolved inflammatory signaling is a feature of aging, the result of lingering senescent cells, debris from stressed cells, and other processes. When persistent over time, inflammatory signaling is highly disruptive to cell and tissue function, altering behavior in ways that contribute to a wide variety of pathologies. In the vasculature, this includes atherosclerosis, calcification, loss of compliance in the vascular smooth muscle responsible for contraction and dilation of blood vessels, and a range of more subtle problems, lumped under the heading of endothelial dysfunction, at the inner surface of blood vess...
Source: Fight Aging! - December 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Senolytics May Improve Organ Transplantation
Senescent cells accumulate with age and negatively affect surrounding tissue with their pro-inflammatory secretions. Greater understanding of this contribution to degenerative aging has led to the development of senolytic therapies to selectively destroy these errant cells and thus improve tissue function. Cellular senescence may also occur in tissues undergoing transplantation, a result of the stresses involved, and cause loss of function and related issues following transplantation. Thus senolytics may find a use in the organ transplant industry as a way to improve success rates and patient outcomes following successful ...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging. Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/ Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Intermittent Fasting is Protective Against the Effects of Vascular Aging in the Brain
In this study, we demonstrate for the first time that IF promotes neuroprotective effects in a model of VaD by maintaining the integrity of the neurovascular structures in the brain. We specifically show that IF attenuated vascular pathology by reducing microvascular leakage and blood-brain barrier dysfunction, while maintaining the expression of tight junction (TJ) proteins. IF was also effective in decreasing white matter lesion formation, hippocampal neuronal cell death and cell death markers, while maintaining myelin basic protein levels. Our data suggest that the effects of IF on the structural integrity of the neurov...
Source: Fight Aging! - December 6, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Syncope, hypotension, vomiting and diaphoresis in a 60-something male with Diabetes and Hypertension
I was texted this ECG by one of my partners, with the following history: A 60-something male with diabetes and HTN presented with syncope. Per EMS report, the patient had a syncopal episode at work. On medics arrival, patient noted to be pale and diaphoretic, SBPs 60-80s, complaining of nausea and had one episode of emesis en route, possible hematemesis. There was no chest discomfort, though the patient was non-English speaking and reportedly " stoic " .What do you think?This was my response, in quotes: " I have a sneaking suspicion that this is a mimic.  Tough one! &n...
Source: Dr. Smith's ECG Blog - December 6, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

An elderly woman with acute vomiting, presyncope, and hypotension, and a wide QRS complex
 Written by Pendell MeyersFamily of an elderly woman with many comorbidities called EMS when she suddenly experienced shortness of breath, nausea, vomiting, and near syncope. She was alert and oriented and hypotensive with initial BP 70/50. A 12 lead ECG was obtained by EMS and is shown below:What do you think?There is sinus tachycardia (do not be fooled into thinking this is VT or another wide complex tachycardia!) The ECG is diagnostic of LAD occlusion (or even left main occlusion possibly), with the classic pattern of RBBB and LAFB with huge concordant STE in V1-V2, I, and aVL, with reciprocal depression in mo...
Source: Dr. Smith's ECG Blog - November 11, 2022 Category: Cardiology Authors: Pendell Source Type: blogs

Post doctoral and doctoral opportunities at Basque Center on Cognition Brain and Language (San Sebasti án, Basque Country, Spain)
 FUNDED POSTDOCTORAL CANDIDATE POSITION – Signal Processing in Neuroimaging group at the BCBL- Basque Center on Cognition Brain and Language (San Sebasti án, Basque Country, Spain) www.bcbl.euINFORMATION ABOUT THE POSITION Position: PostdoctoralResearcher Profile: R2, Recognised Researcher (PhD holders or equivalent who are not yet fully independent) / R3, Established Researcher(Researchers who have developed a level of independence)Number of vacancies: 1Project: OpenLocation:  Spain> Donostia-San SebastianResearch Field: Cognitive NeuroscienceJob Statu...
Source: Talking Brains - November 9, 2022 Category: Neuroscience Authors: Greg Hickok Source Type: blogs

What is myocardial contrast echocardiography?
Myocardial contrast echocardiography (MCE) is used for the assessment of myocardial microcirculation and endocardial demarcation. MCE uses gas-filled microbubbles that are inert and remain wholly within the vascular space. These microbubbles have an intravascular rheology similar to that of red blood cells [1]. A continuous intravenous infusion of microbubbles is given to achieve a steady state. These microbubbles are destroyed by high energy ultrasound. The rate of microbubble replenishment within the ultrasound beam is measured and represents the mean red blood cell velocity [2]. Normally, the ultrasound beam fills with...
Source: Cardiophile MD - November 1, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Triggers for IABP
Intra-Aortic Balloon Pump inflates the balloon in diastole and deflates at the onset of systole. This image of the IABP screen shows diastolic augmentation in the pressure tracing. Period during which the balloon remains inflated is shown as a horizontal bar below the ECG tracing at the top. Live visual indication of balloon inflation will also be there in the balloon inflation indicator at the bottom of the screen when the IABP is operational. Any of the several types of triggers can be used for timing for inflation in diastole. ECG trigger: Balloon will be inflated in the middle of the T wave and deflated at the peak o...
Source: Cardiophile MD - October 28, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Understanding “ Damping and Ventricularization ” in cath lab.
“Never take your eyes off the monitor and the pressure curve”  It is one of the basic instructions given to the fellows & technicians as they start engaging the coronary artery and Intubating the coronary ostium in their early cath lab postings. There are two commonly heard noise bites in the cath lab for the beginner. 1. Damping 2.Ventricularization. Damping It is the deformation of the normal arterial pressure curve, with a  blunting of both systolic and diastolic pressure that drops compared to aortic pressure. Extreme damping can mimic a straight line with few wavy undulations. It means the forward f...
Source: Dr.S.Venkatesan MD - October 26, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized coronary artery damping and ventricularization Source Type: blogs

10+1 Commandments For Companies Developing Wearable Health Trackers
Throughout the last couple of years, I have tested and used about 150 devices and gadgets that measure health parameters or vital signs. From the very first Fitbit to A.I.-driven portable ultrasounds, the evolution is real, and I am delighted to have had the opportunity to watch it first-hand. I also use a dozen health trackers to live healthily on a daily basis. Even before the wearable revolution started to unfold – just as I described in The Guide to the Future of Medicine -, I used data in an Excel spreadsheet to know more about my health and boost my motivation. Nowadays, it is unimaginable for me to go out...
Source: The Medical Futurist - October 25, 2022 Category: Information Technology Authors: berci.mesko Tags: Health Sensors & Trackers future Medicine smartwatch technology wearable gc2 Kardia fitness tracker Apple Watch digital health device withings scanwatch Source Type: blogs

What is cardiogenic shock? Cardiology Basics
When the heart is not able to pump enough blood for perfusing the vital organs and the blood pressure falls, it is known as cardiogenic shock. Most important cause of cardiogenic shock is an acute myocardial infarction. Cardiogenic shock can also occur in other conditions like a fulminant myocarditis. In case of myocardial infarction, it is more likely to occur in those who are older, having multivessel coronary artery disease, and in those with a previous myocardial infarction. Cardiogenic shock is a potentially life threatening condition and needs urgent treatment. Even with treatment about half of those with cardiogeni...
Source: Cardiophile MD - October 20, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

A man in his 30s with cardiac arrest and STE on the post-ROSC ECG
Conclusions: outpatients with witnessed cardiac arrest and primary PEA carry a high probability of Massive Pulmonary Embolism________________Case Continued:" Initial ROSC EKG showed what appeared to be in atrial fibrillation with inferior ST elevations, depressions in aVL, concerning for STEMI. "He had multiple cardiac arrests with ROSC regained each time. " Endotracheal tube re-intubation was confirmed multiple times, bilateral breath sounds, yet O2 saturation remained in the 50s and 60s. I was able to visualize the ETT on initial intubation pass through the cords however given his continued hypoxemia, I felt it...
Source: Dr. Smith's ECG Blog - October 10, 2022 Category: Cardiology Authors: Pendell Source Type: blogs