Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Windkessel Effect In Aorta With Experimental Evidence!
Windkessel effect is applicable to large elastic arteries like aorta, which are situated close to the heart. They have more of elastic tissue than muscular tissue. The term Windkessel comes from German language and means air chamber.
Here is an illustration of the Windkessel, used in 18th century, by fire fighters. The additional pressure built up in the air chamber will ensure continuous delivery of water for fire fighting. A similar thing occurs in elastic arteries like aorta. During systole, more blood enters the aorta, than what leaves the aorta, because aorta expands. This additional blood received during systole, is ...
Source: Cardiophile MD - March 24, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Improving Stem Cell Therapies that Promote Blood Vessel Generation in Ischemic Tissue
Stem cell therapies are one of the approaches to treating progressive loss of blood flow to tissues, such as results from severe atherosclerosis, in which important blood vessels are narrowed or even blocked. Unfortunately first generation stem cell therapies are variable in outcome, cellular senescence in cell cultures prior to transplantation is poorly controlled, and the transplanted cells die quite quickly. Thus even though the benefits of treatment arise from signaling generated by transplanted cells, rather than cell integrating into tissues, there is much that can be improved. One of the ways in which researchers ar...
Source: Fight Aging! - March 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
GE HealthCare Announces Agreement to Acquire MIM Software
The Anticipated Acquisition Aligns to GE HealthCare’s Precision Care Strategy with the Goal of Strengthening the Company’s Digital Solutions Across Care Pathways
MIM Software Provides AI-Enabled Image Analysis and Workflow Tools Across Multiple Care Areas, Including Oncology, Urology, Neurology, and Cardiology
Today’s Agreement Reinforces GE HealthCare’s Commitment to Integrate Medical Imaging Products in Order to Deliver More Precise, Connected, and Efficient Care Across Disease States
GE HealthCare today announced it has entered into an agreement to acquire MIM Software, a global provider of medical imaging analy...
Source: EMR and HIPAA - January 25, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Andrew Nelson GE Healthcare Health IT Acquisitions Healthcare M&A MIM Software Peter Arduini Taha Kass-Hout Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Hallmarks of Aging in the Context of Sarcopenia
Researchers have implicated numerous mechanisms in the age-related loss of muscle mass and strength leading to the condition known as sarcopenia. While not everyone arrives at a diagnosis of sarcopenia, everyone is subject to the progressive deterioration of muscle tissue. One of the challenges facing attempts to understand age-related disease in detail is that the noteworthy mechanisms of aging form a complex, interacting web of cause and consequence. It is next to impossible to determine which mechanisms are more or less important from observation alone. So while one can mount a good argument for sarcopenia to be driven ...
Source: Fight Aging! - January 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Occlusion myocardial infarction is a clinical diagnosis
Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI.A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist ' s office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg. She was given nitroglycerin which improved her blood pressure, and she completed the procedure. Her arm pain abated. The pain returned that evening and woke her from sleep. She eventually fell back asleep, and woke up feeling normal the next day (the day of presentation). After dinner the day of presentatio...
Source: Dr. Smith's ECG Blog - December 11, 2023 Category: Cardiology Authors: Willy Frick Source Type: blogs
What is the infarct artery? What does the post PCI ECG show? What does the convalescent ECG show?
What is the infarct artery? I usually don ' t ask this question, as it is rarely relevant to the decision to activate the cath lab. This is one case where it made a difference: Right Ventricular MI seen on ECG helps Angiographer to find Culprit LesionNevertheless, it is sometimes a fun academic exercise to try to predict the infarct artery:An elderly patient had onset of chest pain one hour prior. He called 911. Here is the prehospital ECG.What do you think?I think it looks like an inferior posterior OMI. The medics thought so too and activated the cath lab from the prehospital.The Qu...
Source: Dr. Smith's ECG Blog - October 6, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Wound Bed Preparation is a Crucial Strategy to Heal Chronic Wounds
There are dozens of wound care products available, and the practitioner is often overwhelmed and confused by the variety of choices. The best way to choose the correct product is understanding the concept of wound bed preparation – a crucial aspect of wound care that creates a systematic approach to an optimal strategy for wound healing. It encompasses various actions to facilitate the healing process by addressing the condition of the wound bed. Wound bed preparation helps reduce the risk of infection, promotes tissue regeneration, and accelerates the healing process. The following 9 steps are key considerations i...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 24, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care Risk Management aging skin bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Healthcare Quality Improvin Source Type: blogs
What does the ECG show in this patient with chest pain, hypotension, dyspnea, and hypoxemia?
Written by Pendell Meyers, with some edits by SmithA man in his 40s with many comorbidities presented to the ED with chest pain, hypotension, dyspnea, and hypoxemia.The bedside echo showed a large RV (Does this mean there is a pulmonary embolism as the etiology?)Here is his triage ECG:What do you think? Lots of info here.The rhythm is 2:1 atrial flutter. The flutter waves can conceal or mimic ischemic repolarization findings, but here I don ' t see any obvious findings of OMI or subendocardial ischemia.The QRS is around 100 msec wide (narrow), but with very abnormal morphology including a large R-wave in V1, dee...
Source: Dr. Smith's ECG Blog - August 14, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Chest pain and T wave inversion, NSTEMI?
Case submitted and written by Dr. Mazen El-Baba and Dr. Emily Austin, with edits from Jesse McLarenA 50 year-old patient presented to the Emergency Department with sudden onset chest pain that began 14-hours ago. The nurse alerted the MD because the patient was still symptomatic, diaphoretic and “looking unwell”. What do you think? ECG interpretation: sinus rhythm, normal conduction (PR, QRS, and QTc), normal axis, delayed R-wave progression, and normal voltages. There ’s primary TWI inferiorly (aVF and III) and V6, with reciprocal tall T-wave in lead I/aVL, and a Q wave in III. The...
Source: Dr. Smith's ECG Blog - August 10, 2023 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Outpatient Vascular Care: Good, bad or ugly?
BY ANISH KOKA
Filling in the holes of recent stories in the New York Times, and Propublica on the outpatient care of patients with peripheral arterial disease
Most have gotten used to egregiously bad coverage of current events that fills the pages of today’s New York Times, but even by their now very low standards a recent telling of a story about peripheral artery disease was very bad.
The scintillating allegation by Katie Thomas, Jessica Silver-Greenberg and Robert Gebeloff is that “medical device makers are bankrolling doctors to perform artery clearing procedures that can lead to amputations...
Source: The Health Care Blog - July 24, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Anish Koka Medical Devices Outpatient vascular care Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
8 Risk Factors Of Low Blood Pressure
Conclusion
In a nutshell, understanding the risk factors associated with low blood pressure is essential for maintaining good health.
Individuals with certain risk factors, such as age, medication usage, underlying medical conditions, dehydration, prolonged bed rest, nutritional deficiencies, pregnancy, and inherited factors, should be particularly aware of the potential for low blood pressure.
Regular monitoring of blood pressure, communication with healthcare providers, and appropriate management strategies are important for individuals with these risk factors to ensure their well-being.
Furthermore, diet pla...
Source: The EMT Spot - June 23, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Heart Transplantation with Donor Hearts Harvested After Circulatory Death
Conventionally, heart transplantation is done using donor hearts obtained after brain death of the donor. That means the heart was still beating at the time of harvesting. Now a study published in the New England Journal of Medicine has reported on the utility of reanimated hearts obtained after circulatory death [1]. This if found to be useful in the long term, is certainly going to increase the pool of donor hearts available for the patients in the long waiting list for heart transplantation. It was a multi-center, randomized, non-inferiority trial with assignment in 3:1 ratio.
Candidates in the circulatory death grou...
Source: Cardiophile MD - June 10, 2023 Category: Cardiology Authors: Johnson Francis Tags: Cardiac Surgery Source Type: blogs
