An Age-Related Increase in CD47 Expression Impairs Vascular Function
Researchers here provide evidence to indicate that increased expression of CD47 in aged blood vessels impairs a range of functions, from maintenance of these tissues to the generation of new blood vessels. The latter point is interesting given that capillary networks become less dense with age. This is thought to impair blood flow to tissues and thus contribute to age-related loss of function. The animal evidence here suggests that inhibition of CD47 may be a viable strategy to reduce the impact of aging on the vasculature, and thus also many of the consequences of vascular aging throughout the body.
The aged popu...
Source: Fight Aging! - July 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for Oxytocin to Reverse Impairment of Synaptic Plasticity by Amyloid- β
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - July 28, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests.
We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Hyperbaric Oxygen Treatment Improves Cerebral Blood Flow in a Small Clinical Trial
In the study noted here, researchers provide evidence for a few months of hyperbaric oxygen treatment to increase blood flow to the brain, perhaps in large part by spurring greater growth of small blood vessels in brain tissue. In older patients this produced improvements in measures of cognitive function. There is a good deal of evidence in the literature to suggests that changes in blood flow to the brain cause altered cognitive function. Consider that exercise improves memory function, for example, both immediately following exercise, and then over the long term. Further, it is the case that capillary networks decline i...
Source: Fight Aging! - July 24, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Massive Transfusion for Motorcycle Collision with Hemorrhage, Troponin Elevated.
This ECG was done in a middle aged woman who was in a motor vehicle collision in which her vehicle " T-boned " another, so there was trauma to the anterior chest. She had multiple rib fractures as well as serious hemorrhage and underwent massive transfusion.Her initial troponin I, part of a critical care order set, returned at 0.55 ng/mL, and an ECG was recorded:There are no P-waves visible. RBBB and LAFB morphology. Rate 114.This could be a junctional rhythm with RBBB and LAFB.Or, much less likely, it could be a very accelerated escape rhythm from the posterior fascicle.Either could be a result of myocardial contusi...
Source: Dr. Smith's ECG Blog - July 2, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Repost: 63 minutes of ventricular fibrillation, followed by shock. What is going on?
In this study, 5% of VF arrest was due to PE: V fib is initial rhythm in PE in 3 of 60 cases. On the other hand, if the presenting rhythm is PEA, then pulmonary embolism is likely. When there is VF in PE, it is not the initial rhythm, but occurs after prolonged PEA renders the myocardium ischemic.--Another study by Courtney and Kline found that, of cases of arrest that had autopsy and found that a presenting rhythm of VF/VT had an odds ratio of 0.02 for massive pulmonary embolism as the etiology, vs 41.9 for PEA. ===================================MY Comment by KEN ...
Source: Dr. Smith's ECG Blog - June 27, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Blood Volume Analysis Using The BVA-100: Interview with Michael Feldschuh, Daxor CEO
This study highlights the
value of our technology and its potential to improve heart failure outcomes.
There have been dozens of peer-reviewed studies that have established
the value of the BVA-100 test for clinical use, confirming that accurate blood
volume measurement leads to better informed physicians, better treatment
strategies, and improves patient outcomes and resource utilization.
Medgadget: What are the problems with surrogate measures of blood volume that clinicians sometimes use in the absence of a device such as the BVA-100?
Michael Feldschuh: Physicians predominantly rely on
clinical assessment...
Source: Medgadget - June 8, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Anesthesiology Cardiac Surgery Cardiology Critical Care Emergency Medicine Exclusive Source Type: blogs
Syncope and Chest Pressure, then an Unusual Bradycardia with Shock
This case is from one of our fantastic 3rd year residents, Aaron Robinson.A woman in her 60s with SyncopeA woman in her 60s presented to a facility with syncope. She had a history of CHF, pulmonary hypertension,CAD s/pCABG, and ESRD on hemodialysis. She had a dialysis run the day prior. Prehospital VS were: BP 115/70, HR 65, RR 12. The patient did not have a 12 lead completed pre-hospital.She arrived at the ED awake, alert, and complaining only ofmild chest discomfort. A 12 lead ECG was immediately completed:Aaron showed this to me and this is what I said:Suggestive of inferior posterior MI, but not dia...
Source: Dr. Smith's ECG Blog - May 15, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Pulmonary thromboendarterectomy
Pulmonary thromboendarterectomy is the standard surgical treatment for chronic thromboembolic pulmonary hypertension (CTEPH) if the surgical risk is reasonable to tolerate a prolonged surgery. The centre and surgeon should also have adequate annual volume of cases to maintain competence. CTEPH may occur in about 4% of patients after an episode of acute pulmonary thromboembolism over a one year period. There are persons with CTEPH who do not have a distinct previous history of acute pulmonary embolism as well.
Pulmonary thromboendarterectomy is a technically challenging procedure and hence the importance of operator’...
Source: Cardiophile MD - April 25, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery chronic thromboembolic pulmonary hypertension CTEPH Source Type: blogs
Camera Images Blood Perfusion at High Resolution Thanks to Pulse Oximeter
How blood moves throughout the body and into the smallest capillaries is hard to observe using existing imaging methods. Yet, poor blood perfusion can be an indicator for a variety of medical conditions, potentially serving as a diagnostic tool and a way to help manage diseases.
Infrared thermography is a decent tool for this, but it is expensive, slow, and not very accurate. Researchers at Rice University have now developed a much cheaper technology that seems to perform significantly better at blood perfusion imaging than anything else currently in existence.
The system uses a conventional optical camera to det...
Source: Medgadget - April 20, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Anesthesiology Cardiology Dermatology Diagnostics Emergency Medicine Pain Management Pathology Radiology Sports Medicine Surgery Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Evidence for Loss of Capillary Density to be Important in Impaired Muscle Function
Aging is accompanied by a reduction in the density of capillary networks throughout the body, for reasons that are not well understood in depth. The regulation of angiogenesis, the processes of blood vessel formation, is observed to change for the worse, but why does this happen? Which of the underlying forms of accumulating molecular damage cause this? Another important question is the degree to which this loss contributes to specific functional declines, such as that of muscle tissue. Researchers here report on the development of an animal model in which capillary density is first reduced, and then somewhat restored via ...
Source: Fight Aging! - March 4, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
FDA Clears First Pulse Oximeter to Measure Breathing Rate
Masimo just received the first FDA clearance for a fingertip pulse oximeter that can measure respiration rate. The MightySat Rx spot-check pulse oximeter includes a technology known as Respiration Rate from the Pleth (RRP) that makes it unnecessary to perform manual counts or use chest electrodes to measure respiration rate.
The device can be used in the clinic, but is now also indicated for at-home use. In addition to respiration rate, it measures oxygen saturation, pulse rate, perfusion index, and Masimo’s Pleth Variability Index (PVi). It also features the company’s well-known Measure-through Motion a...
Source: Medgadget - March 3, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Anesthesiology Cardiology Critical Care Medicine Pediatrics Surgery Source Type: blogs
Ventricular Fibrillation, ROSC after perfusion restored by ECMO, then ECG. Protocols can be overridden by Physician Judgment.
A middle-aged male had sudden chest pain and called 911. First responders arrived. Then the patient arrested. Chest compressions were started immediately. Paramedics arrived a few seconds later and found the patient in ventricular fibrillation. He could not be defibrillated after 3 attempts. He was intubated, given epinephrine and amiodarone, and transported.He arrived in the ED 35 minutes after arrest. He remained pulseless and in V Fib.Defibrillation was not successful.Cannulation for ECMO (Extracorporeal life support -- ECLS) was begun.He was debribrillated again and had brief (...
Source: Dr. Smith's ECG Blog - January 23, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Machine Keeps Livers Alive for a Week, Revives Injured Ones
A Swiss collaboration of clinical researchers from University Hospital Zurich, ETH Zurich, Wyss Zurich, and the University of Zurich has created a machine that can keep human livers alive for up to a week. For comparison, current methods of perfusion can keep livers going for about 24 hours.
Moreover, the same device can be used to rehabilitate injured livers so that they’re healthy enough to be used for transplants. The multi-parameter device is described in journal Nature Biotechnology, where the researchers detail how the device, a goal of the Liver4Life project of Wyss Zurich, can manage a liver outside a huma...
Source: Medgadget - January 14, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Surgery Source Type: blogs
