Management of aortic dissection
Aortic dissection is the most common aortic emergency. It is one of the three acute aortic syndromes, the others being aortic intramural hematoma and penetrating aortic ulcer. It has a grave prognosis with 20% pre hospital and 30% in hospital mortality. Aortic dissection is generally considered as acute when diagnosis is made within 14 days of onset and chronic after that. An intimal and medial tear in the aorta causes blood to seep into the media and the false lumen usually progresses along a variable extend of the aorta. Important risk factors for aortic dissection are hypertension, Marfan syndrome and bicuspid aortic ...
Source: Cardiophile MD - May 4, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Angiography and Interventions Cardiac Surgery Source Type: blogs
Troponin positivity in AVNRT: A panic reaction and its mechanism.
Here is an uncommon story of a patient with palpitation,SVT , Troponin +ve, and suspected ACS.
Palpitation in ER ⇒ {Tachycardia +Troponin positive ≠ ACS}
Mechanism of troponin elevation following any SVT
At high heart rates (>200) myocardium is subjected to non-Ischemic mechanical strain & squeeze. Minute amounts of Troponin is let out like a myocardial juice into the circulation (Like atrial natriuretic peptide release which causes polyuria during AVNRT)
Tropinin releases have been shown to correlate with both heart rate and duration of ST depression (Subendocardial strain /AVRT left lateral pathways)
Short d...
Source: Dr.S.Venkatesan MD - May 1, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized avnrt avrt af biomarkers in tachycardia cpk troponin in avrt false positive troponin in avnrt svt troponin t troponin 1 Source Type: blogs
Positron Emission Tomography (PET) in Cardiology
Positron emission tomography (PET) imaging is useful in assessment of myocardial perfusion and viability, atherosclerotic plaque activity as well as cardiac innervation in heart failure. PET is also useful in prosthetic valve endocarditis, endocarditis associated with cardiac implantable electronic devices (CIED), infiltrative cardiomyopathy, aortic stenosis and cardio oncology [1].
PET imaging has superior diagnostic accuracy compared to SPECT (Single Photon Emission Computed Tomography). It has improved spatial and temporal resolution and can measure regional blood flow and has less radiation. In PET, high energy gamma...
Source: Cardiophile MD - April 20, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Positron emission tomography Source Type: blogs
Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Future of Cryopreservation
The ability to cryopreserve and thaw organs via vitrification, without ice formation and significant tissue damage, allowing for indefinite storage time, would go a long way towards simplifying the logistics and reducing the costs of present organ donation and future tissue engineering of organs for transplantation. Cryopreservation via vitrification also offers the possibility of indefinitely storing the terminally ill and recently deceased until such time as medical science advances to the point of restoration. This has been practiced for several decades by the small cryonics industry.
Cryonics is a long shot, but...
Source: Fight Aging! - April 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
3D Printed Microfluidic Bioreactor for Brain Organoid Culture
Researchers at MIT and the Indian Institute of Technology Madras have developed a 3D-printed microfluidic bioreactor that can be used to culture and study brain organoids. The tiny self-organizing nodules of brain tissue are very useful in studying neurological disease and the effects of drugs. However, the bioreactors used to grow brain organoids can be bulky and costly, and do not always allow for easy viewing of the organoids as they grow. This latest technology aims to provide a low-cost organoid bioreactor using the benefits of 3D printing and microfluidics.
Organoids offer a chance to create ‘mini organs,’ and...
Source: Medgadget - April 8, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Neurology Neurosurgery Oncology Source Type: blogs
Fight Aging! Newsletter, April 5th 2021
In this study, the research team designed a way to identify small molecules that improve the function of ABCA1 in the body while avoiding unwanted effects to the liver. The researchers honed in on a specific small molecule, CL2-57, due to its ability to stimulate ABCA1 activity with positive effects on liver and plasma triglycerides. The use of this compound showed improved glucose tolerance and insulin sensitivity, as well as reduced weight gain, among other beneficial effects.
Age-Related Upregulation of Autophagy as a Possible Contribution to Bat Longevity
https://www.fightaging.org/archives/2021/04/age-rel...
Source: Fight Aging! - April 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Engineered Cells Drive Blood Vessel Formation Following Stroke to Restore Lost Function in Mice
Researchers have recently demonstrated a cell therapy approach that drives greater blood vessel formation in the brain. In mice this treatment restores most of the loss of motor function that occurs following a stroke, a surprisingly large restoration given that the brain is notoriously lacking in regenerative capacity. Therapies capable of inducing greater blood vessel growth are of interest more generally in aging, as the density of capillary networks diminishes with age, contributing to cell and tissue dysfunction due to a reduced supply of nutrients and oxygen. An approach that allows for the safe restoration of capill...
Source: Fight Aging! - March 31, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Nonspecific symptoms with RBBB and New ST Elevation. Anterior STEMI, right? What does the echo show?
A 50-something male with a history of COPD and substance use disorder who presented with generalized weakness and exacerbation of chronic back pain that is now radiating to his neck, and headache. He also developed nausea, alternating " hot and cold flashes " , and generalized weakness the previous evening. He became anxious about his symptoms and then used crack cocaine as well as drank alcohol last night. His symptoms have persisted since then. He states he has felt short of breath since last night. He denies any chest pain, though notes he has a " odd " sensation in his chest. Vital signs w...
Source: Dr. Smith's ECG Blog - March 28, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bile Duct Organoids as an Approach to Liver Repair
This study therefore confirmed that their cell-based therapy could be used to repair damaged livers.
Link: https://www.cam.ac.uk/research/news/lab-grown-mini-bile-ducts-used-to-repair-human-livers-in-regenerative-medicine-first (Source: Fight Aging!)
Source: Fight Aging! - February 25, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immun...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Aging Microvasculature and Alzheimer's Disease
The microvasculature of the body diminishes with age, and this is thought to be a major contributing factor in the progression of age-related loss of organ function, particularly in energy-hungry tissues such as muscles and the brain. Every tissue is densely packed with tiny blood vessels, hundreds of capillaries passing through every square millimeter in cross-section. This small-scale microvasculature is needed in order to efficiently deliver sufficient nutrients to all cells in a tissue. Absent capillaries, perfusion of nutrients is only useful over a very short distance indeed, and its effectiveness declines quickly as...
Source: Fight Aging! - February 16, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why didn ’ t you try ECMO for my dad , doctor ? I feel really guilty !
It is just past midnight: This is a gloomy conversation between a patient’s son and a cardiologist in the silent waiting room, just outside the dim-lit ICU of a popular 4-star hospital in Chennai.
“I am sorry to say, Mr. B., your father didn’t make it. Has succumbed to the heart attack. We have been trying to resuscitate him for the past one hour. We have done everything. We have managed to open up IRA, and 2 more critical blocks still it couldn’t help. It was a massive one. Sorry again.
“Doctor, I feel very bad. What went wrong, I want to know. Doc, did you try ECMO ?,” the ...
Source: Dr.S.Venkatesan MD - February 1, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Cardiology -Technology ecmo IABP impella tandem heart ecmo Source Type: blogs
Wellens' syndrome: to stent or not? IVUS negative, Symptoms persist, Stress Testing, Instantaneous Wave Free Ratio, and Fractional Flow Reserve.
A 55 y.o. male with no cardiac PMHX presented for 2 weeks of exertional chest pain, worsened on the day prior to presentation. On the day of presentation, the chest discomfort was particularly intense, and associated with diaphoresis and nausea. It was resolved (pain free) when the ECG was recorded:This ECG was read as " nonspecific " by the providers. What do you think?These is classic Wellens ' pattern A (biphasic, terminal T-wave inversion), and it isWellens 'syndrome (Angina, resolved -- pain free -- with preserved R-waves and Wellens ' pattern A T-waves). The morphology of these T-wav...
Source: Dr. Smith's ECG Blog - January 28, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
