Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Researchers Generate Decellularized Livers, Ready for New Cells and Transplantation
In this study, we report successful decellularization of human livers to obtain transplantable whole organ scaffolds. We show proof of concept that these scaffolds can serve as feasible resources for future tissue-engineering purposes. Using a controlled perfusion system, a complete 3D acellular human liver scaffold was generated on a clinically relevant scale and free of allo-antigens. We present the feasibility of systematically upscaling the decellularization process to discarded human livers. Eleven human livers were efficiently decellularized by nonionic detergents by machine perfusion. A careful choice of the decellu...
Source: Fight Aging! - October 13, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Hemodynamics of sudden “ Toilet deaths ” following STEMI !
The age old  statistics , 30 % of deaths following STEMI happen even before patients reach the hospital may still be true. But ,there is an untold story that happen regularly in the rehabilitation phase .Its ironical many  apparently stabilised STEMI patients still lose their life just before they get discharged or within 30 days .More often than not this happens in the toilet when they strain for defecation. At least a dozen deaths I have witnessed in the last few years. Of course we have resuscitated many near deaths as well. What exactly happens to these ill-fated patients inside the toilet  ? Straining is often an ...
Source: Dr.S.Venkatesan MD - October 1, 2017 Category: Cardiology Authors: dr s venkatesan Tags: acute coroanry syndrome Cardiology -Interventional -PCI cardiology -Preventive Cardiology -unresolved questions acs hemodynamics in LAD following valsalva predischarge stress test primary pci stemi Sudden cardaic deaths in bath room toil Source Type: blogs

Ignorance based Primary PCI : A landmark article that couldn ’ t correct our coronary Intellect !
How often you assess the success of Primary PCI with degree of  ST segment regression or resolution ? I posed this query to a  freshly hatched , Intelligent and energetic cardiologist in an upscale dedicated heart care center. He said, “No, we don’t .We always go with TIMI flow in IRA .TIMI 3 flow with less than 30% narrowing of IRA is success, that’s it ! He continued ,very often ,we don’t even Insist to take serial ECGs after the procedure .  . . forget about analysing ST segment  !  His body language seemed to suggest,  he didn’t expect such a question (Silly !)  from me , talking ...
Source: Dr.S.Venkatesan MD - September 29, 2017 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized pPCI primary pci stemi st segment regression more important than ira patency st segment regressionafter ppci timi blush score timi three flow Source Type: blogs

Masimo ’s Slim and Portable Rad-97 Pulse CO-Oximeter FDA Cleared and Now Available
Masimo won FDA clearance and just announced full market release of its Rad-97 Pulse CO-Oximeter. It’s available as is, or with either a built-in blood pressure cuff or a capnography (CO2) attachments. The monitor comes with Masimo’s well established Measure-through Motion and Low Perfusion SET pulse oximetry and its rainbow technologies. The device has a narrow, space saving design, sporting a high definition touch screen through which all the settings are accessed. It has an internal rechargeable battery that provides enough juice for about four hours. It seems like it would be perfectly suited for ambulanc...
Source: Medgadget - September 20, 2017 Category: Medical Devices Authors: Editors Tags: Anesthesiology Cardiology Critical Care Emergency Medicine Pediatrics Source Type: blogs

Fight Aging! Newsletter, September 4th 2017
In conclusion, KPE delays intrinsic skin aging process by inhibiting cellular senescence and mitochondrial dysfunction. KPE does not only attenuate cellular senescence through inhibition of the p53/p21, p16/pRb, and PI3K/AKT signaling pathways but also improve mitochondrial biogenesis through PGC-1α stimulation. Consequently, KPE prevents wrinkle formation, skin atrophy, and loss of elasticity by increasing collagen and elastic fibers in hairless mice. The Society for the Rescue of our Elders https://www.fightaging.org/archives/2017/08/the-society-for-the-rescue-of-our-elders/ The Society for the Res...
Source: Fight Aging! - September 3, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Researchers Replace Most of Lung ’s Cells While Retaining Vascular Functionality to Repopulate New Ones
Some tissue types have the ability to have their cells populate a synthetically created scaffold or re-populate decellularized tissue harvested elsewhere. Bioengineered lungs, on the other hand, require a vascular network to exist in order for new cells to settle and for the organ’s normal functions to take place. This has been one reason why little progress has taken place to develop a functional lab-made human lung. Now researchers at Columbia University have been able to remove the pulmonary epithelium from a rat’s lungs while preserving the vascular endothelium and its functionality along with fibroblasts,...
Source: Medgadget - August 31, 2017 Category: Medical Devices Authors: Editors Tags: News Source Type: blogs

More Evidence to Reinforce " Use It or Lose It, " Even in Later Life
Most older people exercise the body and mind far less than they should; as a consequence some degree of the frailty observed in old age in wealthier parts of the world is preventable, a case of neglect rather than unavoidable outcome. You can't choose not to age, yet, but you can choose to exert yourself in order to make matters better than they would otherwise be. There are plenty of studies to show that, even in very late life, greater levels of mental and physical activity produce benefits. In this paper, the researchers dig deeper to see if certain forms of activity can be tied to specific benefits in cognitive functio...
Source: Fight Aging! - August 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Flavors of DVI
I just completed (a rather long) Day 4 at Aga Khan Hospital, here in Dar es Salaam, Tanzania (in case you didn ' t know where I was). As usual, time flies when you ' re having fun, and I really am enjoying my time here.Today was a day of many hats. In the morning, I played " real doctor " and attended an OB Gyn lecture series beamed over from the Aga Khan University Hospital in Nairobi:The full title was " Female Sexual Dysfunction and its Effects upon Fertility " and it was quite well done. While the lecture will have little impact upon my medical practice, I ' m trying to get the staff used to me hanging around, and I ha...
Source: Dalai's PACS Blog - August 24, 2017 Category: Radiology Source Type: blogs

What happens when you give adenosine to a patient with this rhythm?
A 40-something presented with palpitations and had a regular pulse at 170.Here is his 12-lead ECG:The computer reads supraventricular tachycardia.What is it?It is atrial flutter with 2:1 conduction. It is not PSVT and not sinus.There are clear flutter waves in lead II across the bottom. In V1, there are upright waves that appear to be P-waves but are not: they are atrial waves and it is typical for atrial flutter waves to be upright in V1, whereas sinus P-waves are biphasic in V1.The flutter rate is relatively fast at 334, such that the ventricular rate is 167 (one half the atrial rate).As easy as it may seem to ...
Source: Dr. Smith's ECG Blog - August 23, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs

A Successful Trial of Gene Therapy to Spur Vascular Growth in Heart Disease
One approach to the structural damage that takes place in heart disease is to attempt to spur growth of new blood vessels, to deliver nutrients to heart tissue that is currently poorly supplied. Gene therapy is in principle well suited to this goal, as a range of genes are known to be involved in regulating the processes of blood vessel generation. So far attempts to create a viable treatment haven't gone so well, unfortunately, but here researchers report success in a recent trial. The results seem promising. At the high level, this approach doesn't address the underlying causes of the situation, the various degenerative ...
Source: Fight Aging! - August 18, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Sudden weakness with bradycaria and bizarre T-waves
An 60-something man complained of sudden weakness. There was no chest pain or SOB. He had normal blood pressure and perfusion and was asymptomatic at rest. He was well appearing.An ECG was recorded:There is a slow, wide rhythm with bizarre T-waves.What is it? What do you want to do?You ' ll note there are P-waves.Look at lead II across the bottom:---There is a P-wave immediately after each T-wave (these do NOT conduct).---There is a P-wave immediately before each QRS. Even though it appears as if that P-wave does not have enough time to conduct, the PR interval is exactly the same for every one of ...
Source: Dr. Smith's ECG Blog - August 13, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs

Sudden weakness with bradycardia and bizarre T-waves
An 60-something man complained of sudden weakness. There was no chest pain or SOB. He had normal blood pressure and perfusion and was asymptomatic at rest. He was well appearing.An ECG was recorded:There is a slow, wide rhythm with bizarre T-waves.What is it? What do you want to do?You ' ll note there are P-waves.Look at lead II across the bottom:---There is a P-wave immediately after each T-wave (these do NOT conduct).---There is a P-wave immediately before each QRS. Even though it appears as if that P-wave does not have enough time to conduct, the PR interval is exactly the same for every one of ...
Source: Dr. Smith's ECG Blog - August 13, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs

Fight Aging! Newsletter, July 17th 2017
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group. Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Update from the Methuselah Foundation's Vascular Tissue Challenge
Today, an update on the Vascular Tissue Challenge arrived in my in-box. It's been a year or so since the Methuselah Foundation and NASA jointly announced the Vascular Tissue Challenge, conducted as a part of the foundation's New Organ initiative. The challenge is a $500,000 research prize intended to draw greater attention to - and investment in - efforts that aim to surmount the greatest present roadblock in the field of tissue engineering: how to build tissues that contain the capillary networks required to sustain them. Natural tissues are packed with capillaries, hundreds passing through every square millimeter examine...
Source: Fight Aging! - July 14, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs