Fight Aging! Newsletter, November 18th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rapamycin Prevents Deterioration in Brain Circulation in Aged Rats
The mTOR inhibitor rapamycin is well known to slow aging in animal models. As for most of the methods shown to achieve this goal in short-lived species, upregulation of cellular maintenance processes such as autophagy features prominently in the changes produced by the drug. Every one of these approaches that produce sweeping changes in cellular metabolism and a general slowing of age-related decline provides the research community with an essentially unlimited range of projects to undertake when it comes to assessing specific metrics of aging and how they are affected.
Here, researchers look at how rapamycin affect...
Source: Fight Aging! - November 14, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
New cause for differential cyanosis : The North-South syndrome
Differential cyanosis classically occurs in PDA with reversal of shunt when raised PA pressures /PVR is able to supersede the systemic Aortic pressure and drive the blood from LPA to descending Aorta bringing down the lower limb saturation.
Of course, this can be undone by the presence of any other intra-cardiac shunts or aberrant left subclavian that arising from the desaturated descending aorta.
Other causes of reversed differential cyanosis
Where the upper body is cyanosed (desaturated) and the lower half is not. There is a conventional list of conditions.
Transposition of the great arteries (TGA) with patent ductu...
Source: Dr.S.Venkatesan MD - November 12, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized ecmo north south syndrome harlequin syndrome va ecmo side effects Source Type: blogs
Cardiovascular Aging Contributes to Brain Aging
The brain is an energy-hungry organ, and is sensitive to reductions in the blood supply of oxygen and nutrients. Cardiovascular aging can reduce that supply, whether through conditions such as heart failure, or the progressive loss of density in capillary networks that occurs throughout the body with advancing age, or an accelerated pace of rupture of tiny vessels in the brain, or disruption of the blood-brain barrier, allowing unwanted molecules and cells to enter the brain. Thus, as researchers here note, we would expect to see correlations between cardiovascular disease, or risk factors for cardiovascular disease, and d...
Source: Fight Aging! - November 11, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A man in his 50s with witnessed arrest and ST elevation in aVR
Written by Meyers, edits by SmithA 50-ish year old man was working construction when he suddenly collapsed. Coworkers started CPR within 1 minute of collapse. EMS arrived within 10 minutes and continued CPR and ACLS, noting alternating asystole and sinus bradycardia during rhythm checks. He received various ACLS medications and arrived at the ED with a perfusing rhythm.Initial vitals included heart rate around 100 bpm and BP 174/96. Here is his initial ECG, very soon after ROSC:What do you think?Sinus tachycardia. There is incomplete RBBB (QRS duration less than 120 ms). There is diffuse STD, maximal in V4-V5 a...
Source: Dr. Smith's ECG Blog - November 2, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
40-something male in a head-on Motor Vehicle Collision and Splenic Injury
A 40-something male presents to the stabilization room for evaluation following head on motor vehicle collision (MVC). Pt was reported restrained driver, hit at city speeds, with + airbag deployment.The MVC was unquestionably caused by the other car, not by this driver.The patient complained to EMS of chest pain and a prehospital EKG en route was concerning for STEMI.The patient was at all times hemodynamically stable, without evidence of any profuse bleeding.He had an ECG recorded on arrival to the ED:Anterior and Inferior STEMI with diffuse hyperacute T-waves. This ECG really can ' t be anything else.&nb...
Source: Dr. Smith's ECG Blog - October 26, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
A 40-Something male with a " Seizure, " Hypotension, and Bradycardia
This is by one of ouroutstanding 3rd year residents, Aaron Robinson, with some edits and comments by SmithEMS responded to a reported seizure in a 42 year old male. Per bystanders, he went down after some intense sporting activity, and had “shaking” type movement. He reports no personal or familial history of seizures.One of our EMS Fellows along with a Senior EM Resident were on duty that evening, and arrived on the scene with the Fire Department. When the physicians approached him, he was ashen, diaphoretic, and appeared in shock. Fire was able to obtain a BP of 60/palp and a pulse in the 40s. The physicians quickly ...
Source: Dr. Smith's ECG Blog - October 6, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Shark Fin morphology recognized only by EM physician
Case submitted by Alex Bracey, Written by Alex Bracey and Pendell MeyersA man in his 70s complained of acute chest pain followed by witnessed cardiac arrest. He received immediate bystander CPR prior to EMS arrival. EMS found him in VF and administered 4 shocks, multiple doses of epinephrine, and amiodarone with intermittent ROSC, however he was in arrest on arrival to the ED with ongoing CPR via LUCAS device. Overall down time was 35 minutes from the time of arrest to arrival at the ED.First rhythm check in the ED showed PEA with a wide complex at a rate of approximately 30 bpm. Calcium and epinephine were given at CPR wa...
Source: Dr. Smith's ECG Blog - October 3, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Samsung Unveils Hera I10 Ultrasound System
Samsung is unveiling its new Hera I10 ultrasound system designed for ob/gyn applications. The system integrates a motorized examination chair that can adjust from 18.9″ to a height of 38.6″, so patients don’t have to put up with a conventional exam table.
A large high-def display screen can be moved around as the clinician prefers it, helping to increase productivity and improve ergonomics.
On the side is a convenient rack of transducers and a cable support arm that makes changes easy and reduces the felt weight of the transducers.
As far as the imaging, the Hera I10 features Samsung’s...
Source: Medgadget - September 27, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Ob/Gyn Radiology Reproductive Medicine Source Type: blogs
The Gazillion Of Health Data You Can Measure
From SWOLF through EDA until heart rate, heart rate variability, respiratory rate, single-lead ECG, period tracking, sleep pattern analyzing: dozens of vital signs demonstrate that there’s no single square centimeter of the human body without quantifiable data. As an experiment, we tried to collect every trackable parameter to draw the boundaries of your “health data self”. Let us know if there’s anything left out.
Why is measurement useful? To know thyself
The famous ancient Greek aphorism was inscribed on a
wall in the Temple of Apollo at Delphi, the oracle, which was believed to tell
humans about the plan...
Source: The Medical Futurist - September 26, 2019 Category: Information Technology Authors: nora Tags: Health Sensors & Trackers Personalized Medicine Portable Diagnostics activity blood body brain breathing data fitness health data heart health heart rate lifestyle lung measure measurement meditation quantified self s Source Type: blogs
A 50-something woman with chest pain, BP 230/120, and LBBB with 7 mm ST Elevation
A 50-something woman with history of CHF of unknown etiology, and of HTN, presented for evaluation of chest pressure.Her BP was 223/125, Sp02 98% on RA. HR 106, RR 18. Here was her ED ECG:There is sinus rhythm with Left Bundle Branch Block (LBBB)There is a large amount of ST Elevation in V2 and V3 (more than 5 mm)Thus, this meets the unweighted Sgarbossa Criteria of 5 mm of discordant ST ElevationBut it does NOT meet the Smith Modified Sgarbossa Criteria, which depend on the ST/S ratio.This ratio is critical because LBBB with very large depolarization voltage (QRS) also has very large repolarization voltage (ST/T).Her...
Source: Dr. Smith's ECG Blog - September 24, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Ethicon ’s New ECHELON CIRCULAR Powered Stapler
Ethicon, a part of J&J, just unveiled the ECHELON CIRCULAR, which the company touts as the first powered circular stapler specifically designed for colorectal, gastric, and thoracic procedures.
The device features so-called “Gripping Surface Technology” that is supposedly more tender on the tissues being stapled, distributing forces to reduce potential damage. Also, the staples are slightly twisted when applied, and so grip tissues from different angles, which Ethicon says distributes compression better and reduces leaks along the staple line while not compromising perfusion. Moreover, compared with ...
Source: Medgadget - September 24, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: GI Surgery Thoracic Surgery Source Type: blogs
Suitable Antigens can Attract T Helper Cells that Act to Promote Blood Vessel Regrowth
The immune system is deeply involved in the intricate, complex processes of tissue regeneration, and the research community has much left to catalog of the countless interactions that take place between immune cells and other cell populations during regeneration. One interesting discovery is that a subclass of T helper cells can encourage growth of blood vessels. Thus, given a way of attracting and retaining the appropriate T helper cells in a tissue suffering ischemia, it may be possible to encourage sufficient regrowth of blood vessels to treat conditions involving inadequate blood flow, such as critical limb ischemia. R...
Source: Fight Aging! - August 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Biomaterial Tricks Immune System to Grow New Blood Vessels
Researchers from Harvard’s Wyss Institute have developed a new biomaterial that can activate T cells to promote vascularization of ischemic tissues. Their work demonstrates that the biomaterial results in local blood vessel development, increased perfusion, and new muscle growth after ischemia.
Various compounds have been tested to try to improve angiogenesis in tissues that have undergone ischemia, but they have failed in various ways. New interest has developed in using the body’s own immune system to help aid this process. To this end, the Wyss researchers developed unique biomaterials to modulate the local i...
Source: Medgadget - August 7, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Cardiac Surgery Materials Plastic Surgery Rehab Vascular Surgery Source Type: blogs
Bizarre T-wave inversions, with Negative U-waves and Very long QT. And a myocardial viability study.
This 60-something year old male was admitted and his hospital course complicated by GI bleed, hemodynamic instability, and a nadir hemoglobin less than 5 g/dL. An ECG was relatively normal.The next AM, his potassium was measured at 2.9 mEq/L, so another ECG was recorded.He was asymptomatic.The previous ECG from one week prior had been relatively normal.There are bizarre inverted T-waves and also inverted U-waves (see the 2nd inverted bump?)The QT is incredibly longThere is some subtle STE in inferior leads but also STE in I, aVL.There is STE before the bizarre TU inversion in leads V3-V6.There are some artifacts that...
Source: Dr. Smith's ECG Blog - July 23, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
