Poststroke White Matter Hyperintensities and Physical Activity: A CANVAS Study Exploratory Analysis
Conclusions Meeting PA guidelines was associated with lower WMH volume at 12 months in univariable analysis, but not in multivariable analysis. Age consistently predicted greater WMH volume. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - August 19, 2022 Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research

Effects of cGMP/Akt/GSK-3 β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing
In conclusion, NPR-A interacts with ANP to regulate PGC expression, and influence the expression of cGMP during RAP, which involves in the Akt/GSK-3β signaling pathway. From the aforementioned points we conclude that cGMP regulates ANP secretion by the Akt/GSK-3β signaling pathway during atrial pacing. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - August 19, 2022 Category: Physiology Source Type: research

Association of macular and choroidal perfusion with long-term visual outcomes after macula-off rhegmatogenous retinal detachment
Conclusions OCTA measures of vascular perfusion in the macula may provide new pathophysiological insights and prognostic information related to macula-off RRD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 19, 2022 Category: Opthalmology Authors: Chua, J., Ke, M., Tan, B., Gan, A. T. L., Lim, L. S., Tan, G. S., Lee, S. Y., Wong, E., Schmetterer, L., Cheung, N. Tags: Original articles - Clinical science Source Type: research

Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis
AbstractVEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS) derived from NADPH oxidases (NOXs) and mitochondria, which plays an important role in postnatal angiogenesis. However, it remains unclear how highly diffusible ROS signal enhances VEGFR2 signaling and reparative angiogenesis. Protein disulfide isomerase A1 (PDIA1) functions as an oxidoreductase depending on the redox environment. We hypothesized that PDIA1 functions as a redox sensor to enhance angiogenesis. Here we showed that PDIA1 co-immunoprecipitated with VEGFR2 or colocalized with either VEGFR2 or an early endosome marke...
Source: Angiogenesis - August 19, 2022 Category: Molecular Biology Source Type: research

The Evaluation of Constant Coronary Artery Flow versus Constant Coronary Perfusion Pressure During Normothermic Ex Situ Heart Perfusion
Evidence suggests that hearts that are perfused under ex-situ conditions lose normal coronary vasomotor tone and experience contractile failure over a few hours. We aimed to evaluate the effect of different coronary perfusion strategies during ex situ heart perfusion on cardiac function and coronary vascular tone. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - August 19, 2022 Category: Transplant Surgery Authors: Xiao Qi, Sanaz Hatami, Sabin Bozso, Max Buchko, Keir A. Forgie, Carly Olafson, Mubashir Khan, Sayed Himmat, Xiuhua Wang, David S. Nobes, Jason P. Acker, Jayan Nagendran, Darren H. Freed Tags: ISHLT Annual Meeting Papers Source Type: research

Surgical unroofing of myocardial bridges
Myocardial bridging occurs when an epicardial coronary artery has an intramyocardial segment that is compressed during systole, and may result in decreased perfusion pressure during early diastole (Figure 1) (9). The prevalence has been reported from one to five percent from angiographic series, although the true prevalence is likely much higher due to asymptomatic variants, as evidenced by much higher rates of incidence in autopsy series (10,11). The literature suggests that myocardial bridges may be responsible for serious adverse events such as myocardial ischemia, acute coronary syndromes, left ventricular dysfunction,...
Source: Operative Techniques in Cardiac and Thoracic Surgery - August 19, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Perry Choi, Hanjay Wang, Jennifer Tremmel, Ingela Schnittger, Kan Saito, Michael Ma, Teimour Nasirov, Jack Boyd Tags: Congenital Source Type: research

The Protective Effect of Interval Exercise on Myocardial Ischemia-Reperfusion Injury in Players
Biomed Res Int. 2022 Aug 8;2022:4353340. doi: 10.1155/2022/4353340. eCollection 2022.ABSTRACTIn recent years, the popularity of sports has been increasing. In the high-intensity competition, many players have been injured; most of them are myocardial ischemia. With the development of medical science and technology, myocardial ischemia can be reperfusion. However, sometimes, the function of tissues and organs cannot be restored, but the dysfunction and structural damage of tissues and organs can be aggravated. Therefore, it is necessary to actively carry out intermittent exercise to protect players from myocardial ischemia-...
Source: Biomed Res - August 18, 2022 Category: Research Authors: Wei Wang Source Type: research

Procedural Efficiency, Efficacy, and Safety of High-Power, Short-Duration Radiofrequency Ablation Delivered by STSF Catheter for Paroxysmal Atrial Fibrillation
CONCLUSIONS: The HPSD strategy delivered by the STSF catheter was superior to conventional LPLD ablation through the ST catheter with respect to efficiency, acute procedural effectiveness, short-term safety, and the risk of heart failure in patients with paroxysmal AF.PMID:35979002 | PMC:PMC9377865 | DOI:10.1155/2022/6009275 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 18, 2022 Category: Complementary Medicine Authors: Cheng Cheng Banglong Xu Jianlong Sheng Zheng Huang Fei He Feng Gao Xiaochen Wang Source Type: research

Early stage T1-weighted perfusion magnetic resonance imaging: a factor that predicts local control response in patients with meningioma who underwent gamma-knife radiosurgery
CONCLUSION: Changes between Ktrans on PO3M and pre-GKRS T1-PMRI were more useful in determining the early response to GKRS in patients with meningioma than volumetric changes. Therefore, Ktrans should be taken as a reference to predict the early response to GKRS in follow-up imaging scans.PMID:35981093 | DOI:10.1080/01616412.2022.2112377 (Source: Neurological Research)
Source: Neurological Research - August 18, 2022 Category: Neurology Authors: Anas Abdallah Mehmet Hakan Seyithano ğlu Meliha G ündağ Papaker Ay şe Aralaşmak Sel çuk Yapar G ökhan Baloğlu Source Type: research

Pathophysiology of cognitive dysfunction and the role of combined brain/heart magnetic resonance imaging (Review)
Exp Ther Med. 2022 Jul 14;24(3):569. doi: 10.3892/etm.2022.11506. eCollection 2022 Sep.ABSTRACTNormal cognitive function depends on a continuous and optimally regulated blood supply, and any pathology that further reduces cerebral blood perfusion in addition to that caused by aging could damage or destroy vulnerable neurons of the brain. Furthermore, glucose serves a crucial role as the primary fuel source for the mammalian brain and any disturbance in its circulating concentrations could directly affect brain function. The term cognitive dysfunction (CD), known also as 'brain fog', refers to deficits in attention, verbal ...
Source: Experimental and Therapeutic Medicine - August 18, 2022 Category: General Medicine Authors: George Markousis-Mavrogenis Flora Bacopoulou Genovefa Kolovou Maria-Roser Pons Aikaterini Giannakopoulou Antigoni Papavasiliou George D Kitas George P Chrousos Sophie I Mavrogeni Source Type: research

Rewarming from unwitnessed hypothermic cardiac arrest with good neurological recovery using extracorporeal membrane oxygenation
Perfusion. 2022 Aug 18:2676591221122274. doi: 10.1177/02676591221122274. Online ahead of print.ABSTRACTA 26-year-old man, who was training in bad weather for a mountain ultramarathon, became hypothermic after running for 4 h. He deteriorated and was unable to continue. His running partner went for help. The man suffered an unwitnessed hypothermic cardiac arrest. The on-site management and evacuation are described and included the use of intermittent cardiopulmonary resuscitation and a mechanical device during transport. The patient was successfully resuscitated and rewarmed by Extracorporeal Membrane Oxygenation (ECMO) aft...
Source: Perfusion - August 18, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Les Gordon John Ferris Henning Pauli Source Type: research

Successful treatment of pulmonary mucormycosis ( < em > Lichtheimia spp.) < /em > in a post-partum patient with COVID-19 ARDS requiring extra-corporeal membrane oxygenation using salvage therapy
Conclusion: Pulmonary mucormycosis, even in the non-ECLS population, carries a high mortality. Treatment in pulmonary disease with surgery improves mortality but is not always feasible. Salvage therapy with extended course antifungal medications may be an option for those not amendable.PMID:35979585 | DOI:10.1177/02676591221111031 (Source: Perfusion)
Source: Perfusion - August 18, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Justin Hanks Shinya Unai Alejandro Bribriesco Steven Insler Eileen Yu Jona Banzon Eduardo Mireles-Cabodevila Ahmad Adi Haytham Elgharably James Yun Sudhir Krishnan Source Type: research

GSE211506 Gene expression data from Akkermansia perfusion trial
Contributors : Ignacio Rangel ; Dirk Repsilber ; Michael Muller ; Guido Hooiveld ; Jarrko Saloj ärviSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe studies the effect of Akkermansia perfusion on human by taking biopsies before and after perfusion and assess gene expression.Affymetrix HuGene 1.1 ST arrays were used to assess whole biopsy gene expression profiles (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - August 18, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Sensors, Vol. 22, Pages 6183: Microfluidic-Assisted Human Cancer Cells Culturing Platform for Space Biology Applications
zak Jan Dziuban In the paper, the lab-on-chip platform applicable for the long-term cultivation of human cancer cells, as a solution meeting the demands of the CubeSat biological missions, is presented. For the first time, the selected cancer cell lines&amp;mdash;UM-UC-3 and RT 112 were cultured on-chip for up to 50 days. The investigation was carried out in stationary conditions (without medium microflow) in ambient temperature and utilizing the microflow perfusion system in the incubation chamber assuring typical cultivation atmosphere (37 &amp;deg;C). All the experiments were performed to imitate the condi...
Source: Sensors - August 18, 2022 Category: Biotechnology Authors: Agnieszka Krakos (Podwin) Joanna Jarosz Patrycja Śniadek Mateusz Psurski Adrianna Graja Marcin Bia łas Ewa Oliszewska Joanna Wietrzyk Rafa ł Walczak Jan Dziuban Tags: Article Source Type: research

Cancers, Vol. 14, Pages 3997: Current Imaging Diagnosis of Hepatocellular Carcinoma
rassopoulos Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer related death worldwide. Radiology has traditionally played a central role in HCC management, ranging from screening of high-risk patients to non-invasive diagnosis, as well as the evaluation of treatment response and post-treatment follow-up. From liver ultrasonography with or without contrast to dynamic multiple phased CT and dynamic MRI with diffusion protocols, great progress has been achieved in the last decade. Throughout the last few years, pathological, biological, genetic, and immune-chemical analyses have revealed several tumoral...
Source: Cancers - August 18, 2022 Category: Cancer & Oncology Authors: Evangelos Chartampilas Vasileios Rafailidis Vivian Georgopoulou Georgios Kalarakis Adam Hatzidakis Panos Prassopoulos Tags: Review Source Type: research