Trends in Current Use of Machine Perfusion for Donation after Cardiac Death Donors in the United States
The recent meta-analysis of machine-perfusion techniques for liver transplant by Parente et al.1 provides a much-awaited comprehensive assessment of the current literature on machine perfusion compared to static cold storage. With the promise of optimizing marginal and extended criteria grafts, and minimizing their risk of ischemic reperfusion injury, the transplant community has seen a progressive adoption of various perfusion strategies in the last several years. However, the landscape remains in flux regarding its optimal role and indications. (Source: Journal of Hepatology)
Source: Journal of Hepatology - April 26, 2024 Category: Gastroenterology Authors: Lauren E. Matevish, Parsia A. Vagefi, Madhukar S. Patel Tags: Letter to the Editor Source Type: research
Perfusion drugs for non ‑muscle invasive bladder cancer (Review)
Oncol Lett. 2024 Apr 15;27(6):267. doi: 10.3892/ol.2024.14400. eCollection 2024 Jun.ABSTRACTThe high recurrence rate and poor prognosis of non-muscle invasive bladder cancer (BC) are challenges that need to be urgently addressed. Transurethral cystectomy for bladder tumors is often combined with bladder perfusion therapy, which can effectively reduce the recurrence and progression rates of BC. The present review integrated and analyzed currently available bladder perfusion drugs, mainly including chemotherapeutic agents, immunotherapeutic agents and other adjuvant perfusion drugs. Bacillus Calmette-Guerin (BCG) perfusion w...
Source: Oncology Letters - April 25, 2024 Category: Cancer & Oncology Authors: Jingyuan Qian Qiuchen Zhang Yang Cao Xi Chu Yiyang Gao Haifei Xu Hongzhou Cai Jiajia Wu Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Erratum to: Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation (Magn Reson Med. 2022; 88:1528-1547)
Magn Reson Med. 2024 Apr 24. doi: 10.1002/mrm.30099. Online ahead of print.NO ABSTRACTPMID:38659147 | DOI:10.1002/mrm.30099 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - April 25, 2024 Category: Radiology Authors: Qin Qin David C Alsop Divya S Bolar Luis Hernandez-Garcia James Meakin Dapeng Liu Krishna S Nayak Sophie Schmid Matthias J P van Osch Eric C Wong Joseph G Woods Greg Zaharchuk Moss Y Zhao Zungho Zun Jia Guo Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
Resting state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00423.2023. Online ahead of print.ABSTRACTThe kidneys maintain fluid-electrolyte balance and excrete waste in the presence of constant fluctuations in plasma volume and systemic blood pressure. The kidneys perform these functions to control capillary perfusion and glomerular filtration by modulating the mechanisms of autoregulation. An effect of these modulations are spontaneous, natural fluctuations in nephron perfusion. Numerous other mechanisms can lead to fluctuations in perfusion and flow. The ability to monitor these spontaneous physiological fluctuations...
Source: American Journal of Physiology. Renal Physiology - April 25, 2024 Category: Physiology Authors: Edwin J Baldelomar Darya Morozov Leslie D Wilson Cihat Eldeniz Hongyu An Jennifer R Charlton Adam Bauer Shella D Keilholz Monica L Hulbert Kevin M Bennett Source Type: research
Improved sieving coefficient in perfusion cell culture with reduced effective filtration length of hollow fibers
AbstractThe hollow fiber filter is the primary cell-retention device used in high-density perfusion cell culture and often used in an alternating tangential flow (ATF) configuration. The limited commercially available diaphragm pumps for ATF prevent utilization of vertical space when scaling beyond 500 L. Stacking hollow fiber filters coupled with viscous cell culture imposes vacuum pressure exceeding facility capabilities. Additionally, the longer filter assembly increases the hold-up volume and exceeds the diaphragm pump's fluid exchange capacity. The conventional tangential flow filtration ( TFF) configuration circum...
Source: Biotechnology Progress - April 25, 2024 Category: Biotechnology Authors: Jimmy Vu,
J. Alex Gadberry,
Jon Coffman,
Ken Lee Tags: RESEARCH ARTICLE Source Type: research
“Con: Is Minimal Invasive Extracorporeal Circulation Superior to Conventional Cardiopulmonary Bypass in Cardiac Surgery?”
While individualized treatment is one of the pillars of the evolving practice towards a more physiological perfusion approach, further than “the elections of the artists”, decision-making algorithms considering different strategies to reduce blood product requirements (BPR) during Cardiopulmonary Bypass (CPB), should be implemented by Cardiac Surgery teams, considering the adequacy to circumstances and the cost-benefit balance. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 25, 2024 Category: Anesthesiology Authors: Morillo J. Blanco, M Vives Tags: Pro and Con Source Type: research
Anesthetic management during laparoscopic liver resection in a patient with Fontan physiology and high central venous pressure
The Fontan procedure was developed in 1971 for the surgical palliation of patients with single ventricle physiology [1]. In patients with Fontan physiology, pulmonary perfusion depends on pulmonary vascular resistance and systemic venous pressure. Long-term survival after the Fontan procedure has improved [2]. However, chronically high venous pressure may cause liver congestion and lead to the development of hepatocellular carcinoma (HCC) [3]. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 25, 2024 Category: Anesthesiology Authors: Kousuke Kikuchi, Akira Iura, Naohiro Hara, Takeshi Iritakenishi, Daisuke Hiramatsu, Yuji Fujino Tags: Case Report Source Type: research
Indocyanine green angiography guidance for vascular preservation in skin and nipple sparing mastectomy
ConclusionThis prospective study using preoperative ICG perfusion mapping demonstrated safety, feasibility, and good prognostic outcomes.Level of evidenceIII. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 25, 2024 Category: Cancer & Oncology Source Type: research
The coronary sinus reducer improves angina symptoms in patients with stable CAD
Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01033-xFindings from the ORBITA-COSMIC trial show that treatment of patients with stable coronary artery disease using a coronary sinus reducer improves angina symptoms but does not increase transmural myocardial perfusion. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 25, 2024 Category: Cardiology Authors: Karina Huynh Source Type: research
The intricate physiology of veno-venous extracorporeal membrane oxygenation: an overview for clinicians
Perfusion. 2024 Apr;39(1_suppl):49S-65S. doi: 10.1177/02676591241238156.ABSTRACTDuring veno-venous extracorporeal membrane oxygenation (V-V ECMO), blood is drained from the central venous circulation to be oxygenated and decarbonated by an artificial lung. It is then reinfused into the right heart and pulmonary circulation where further gas-exchange occurs. Each of these steps is characterized by a peculiar physiology that this manuscript analyses, with the aim of providing bedside tools for clinical care: we begin by describing the factors that affect the efficiency of blood drainage, such as patient and cannulae position...
Source: Perfusion - April 24, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Emilia Tomarchio Francesca Momigliano Lorenzo Giosa Patrick Duncan Collins Nicholas A Barrett Luigi Camporota Source Type: research
Comprehensive study of the interplay between immunological and metabolic factors in hepatic steatosis
Int Immunopharmacol. 2024 Apr 23;133:112091. doi: 10.1016/j.intimp.2024.112091. Online ahead of print.ABSTRACTThe pathophysiology of hepatic steatosis is thoroughly reviewed in this comprehensive report, with particular attention to the complex interactions between inflammatory pathways, insulin resistance, lipid metabolism, metabolic dysregulation, and immunological responses in the liver including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). The study highlights the role of immune cell regulation in disease progression and explores the potential of i...
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Arnab Banerjee Debasmita Das Sandip Mukherjee Bithin Kumar Maji Source Type: research
Robotic Left Hepatectomy with En Bloc Biliary Resection and Roux-en-Y Hepaticojejunostomy: A Technique of Portal Venous Tangential Vascular Reconstruction
CONCLUSION: The robotic approach for left-sided perihilar cholangiocarcinoma resections, requiring precise biliovascular management, is safe, feasible, and efficient. This method demonstrates the potential of robotic techniques as an alternative to traditional open surgery.PMID:38656639 | DOI:10.1245/s10434-024-15301-0 (Source: Ann Oncol)
Source: Ann Oncol - April 24, 2024 Category: Cancer & Oncology Authors: Maria Christodoulou Tara Pattilachan Sharona B Ross Sara Larocca Iswanto Sucandy Source Type: research
LncRNA PART1 Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating TFAP2C/DUSP5 Axis via miR-302a-3p
CONCLUSION: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.PMID:38654453 | DOI:10.4070/kcj.2023.0131 (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - April 24, 2024 Category: Cardiology Authors: Min Zeng Xin Wei Jinchao Zhou Siqi Luo Source Type: research
