Growth Pattern of the Neo-Aorta after Arterial Switch Operation during Childhood.
Authors: Cha SG, Baek JS, Yu JJ, Kim YH, Kwon BS, Choi ES, Park CS, Yun TJ Abstract BACKGROUND AND OBJECTIVES: Neo-aortic root dilatation (ARD) and annular dilatation (AAD) tend to develop after arterial switch operation (ASO). However, the trend of neo-aortic growth has not been well established. This paper aims to identify this trend, its associated factors, and predictors of neo-aortic dilatation after ASO. METHODS: We analyzed the growth trend of the neo-aortic root, annulus, and sinotubular junction (STJ) z-scores using random coefficients model and the risk factors affecting neo-aortic dilatation in 163 p...
Source: Korean Circulation Journal - November 11, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Heart Failure with Preserved Ejection Fraction: the Major Unmet Need in Cardiology.
Authors: Shim CY Abstract Heart failure with preserved ejection fraction (HFpEF) has recently been recognized as the single greatest unmet need in cardiovascular medicine. As the population ages and the comorbidity increases, the prevalence of HFpEF increases considerably. Even though there have been large numbers of studies on pathophysiology, diagnosis, and treatment of HFpEF for latest years, there are no current pharmacologic interventions that can reduce mortality. HFpEF is currently understood as a heterogeneous syndrome originated from the interplay of cardiac and extracardiac abnormalities recognized by sys...
Source: Korean Circulation Journal - November 7, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Association Between Subcutaneous Implantable Cardioverter Defibrillator Preimplantation Screening and the Response to Cardiac Resynchronization Therapy.
Authors: Jing R, Jin H, Hua W, Yang S, Hu Y, Zhang S Abstract BACKGROUND AND OBJECTIVES: Preimplantation QRS-T morphology screening (TMS) is a composite tool for selecting subcutaneous implantable cardioverter defibrillator (S-ICD) candidates. However, its role in predicting the patient's response to cardiac resynchronization therapy (CRT) is uncertain. METHODS: A total of 55 consecutive de novo CRT candidates were enrolled between January 2016 and March 2017. Electrocardiogram (ECG) and TMS were performed before and soon after implantation. The ECG parameters were recorded, including QRS duration and morpholog...
Source: Korean Circulation Journal - November 7, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Long-Term Efficacy of Prophylactic Cavotricuspid Isthmus Ablation during Atrial Fibrillation Ablation in Patients Without Typical Atrial Flutter: a Prospective, Multicentre, Randomized Trial.
CONCLUSIONS: In this large and long-term follow-up study, prophylactic CTI ablation had no benefit in patients with paroxysmal AF without typical AFL. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02031705. PMID: 33150753 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - November 7, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Interplay between Saturated Free Fatty Acids and mmLDL Induces Inflammation in LPS-stimulated Macrophages.
Authors: Park JS, Bae SH PMID: 33150754 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - November 7, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Extensive Deep Vein Thrombosis after Electrophysiology Study.
Authors: Kwon CH PMID: 33150755 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - November 7, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Consensus Statement on Coronary Intervention during the Coronavirus Disease 2019 (COVID-19) Pandemic: from the Korean Society of Interventional Cardiology (KSIC).
Authors: Lee KY, Lee BK, Kim WJ, Kang SH, Park TK, Kim SY, Suh JW, Yoon CH, Yang DH, Ryu SK, Kim SH, Lee SY, Chae IH, Korean Society of Interventional Cardiology COVID-19 Task Force Team Abstract Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the novel virus severe acute respiratory syndrome coronavirus-2. The first case developed in December, 2019 in Wuhan, China; several months later, COVID-19 has become pandemic, and there is no end in sight. This disaster is also causing serious health problems in the area of cardiovascular intervention. In response, the Korean Society of Intervent...
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Renin-Angiotensin System Blockade in Acute Myocardial Infarction: Is There a Winner?
Authors: Lee HS, Kang J PMID: 33118333 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Management of Tachycarida-bradycardia Syndrome: To Pace or to Ablate, That Is the Question.
Authors: Shim J PMID: 33118334 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Pediatric Acute Myocarditis: Current Approach to Diagnosis and Treatment.
Authors: Kim SJ PMID: 33118335 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Impact of Hospital Volume of Percutaneous Coronary Intervention (PCI) on In-Hospital Outcomes in Patients with Acute Myocardial Infarction: Based on the 2014 Cohort of the Korean Percutaneous Coronary Intervention (K-PCI) Registry.
This study aimed to determine whether the in-hospital clinical outcomes of patients with AMI in Korea are significantly associated with hospital PCI volumes. METHODS: We selected and analyzed 17,121 cases of AMI, that is, 8,839 cases of non-ST-segment elevation myocardial infarction and 8,282 cases of ST-segment elevation myocardial infarction, enrolled in the 2014 Korean percutaneous coronary intervention (K-PCI) registry. Patients were divided into 2 groups according to hospital annual PCI volume, that is, to a high-volume group (≥400/year) or a low-volume group (
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Is Hospital Percutaneous Coronary Intervention Volume-In-hospital Outcome Relation an Issue in Acute Myocardial Infarction?
Authors: Rha SW PMID: 33118337 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Author's Reply to Heart Transplantation to Fulminant Myocarditis during COVID-19 Outbreak.
Authors: Kim IC, Hwang I, Kim YS, Kim JB PMID: 33118338 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Heart Transplantation to Fulminant Myocarditis during COVID-19 Outbreak.
Authors: Wiwanitkit V PMID: 33118339 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - October 31, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Factors Associated with Awareness, Treatment, and Control Rate of Hypertension among Korean Young Adults Aged 30-49 Years.
CONCLUSIONS: The factors associated with hypertension awareness, treatment, and control were different by sex and age group. Enhancing attention on hypertension among young hypertension and encouraging them to visit clinics would be key strategies to improve hypertension management among the young hypertensive population. PMID: 32975054 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 26, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Percutaneous Edge-to-Edge Mitral Valve Repair.
Authors: Yeo KK, Wong N Abstract Percutaneous edge-to-edge mitral valve repair, using the MitraClip device for severe mitral regurgitation (MR) was first introduced in 2003. Since then, more than 100,000 cases have been performed worldwide and it remains the most established percutaneous therapy available for the treatment of severe MR. Currently, it is indicated for severe, symptomatic functional MR in patients who continue to have significant symptoms despite optimal guideline directed medical therapy, as well as in symptomatic patients with severe degenerative MR who are deemed too high risk for conventional sur...
Source: Korean Circulation Journal - September 26, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein.
CONCLUSIONS: We demonstrated that the proinflammatory milieu with high levels of PA or mmLDL promoted macrophage activation and the expression of associated genes such as Nlrp3, Csf3, and Edn1. Although the TLR4 pathway appeared to be most relevant, additional role of other genes in this process provided insights regarding the potential targets for intervention. PMID: 32975056 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 26, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

2020 Korean Society of Myocardial Infarction Expert Consensus Document on Pharmacotherapy for Acute Myocardial Infarction.
Authors: Kim HK, Ahn Y, Chang K, Jeong YH, Hahn JY, Choo EH, Kim MC, Kim HS, Kim W, Cho MC, Jang Y, Kim CJ, Jeong MH, Chae SC, Task Force on Expert Consensus Document of the Korean Society of Myocardial Infarction (KSMI) Abstract Clinical practice guidelines published by the European Society of Cardiology and the American College of Cardiology/American Heart Association summarize the available evidence and provide recommendations for health professionals to enable appropriate clinical decisions and improve clinical outcomes for patients with acute myocardial infarction (AMI). However, most current guidelines are ba...
Source: Korean Circulation Journal - September 25, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Coronary Microvascular Dysfunction: Is It Distinct Clinical Entity or Common Physiologic Pathway?
Authors: Ahn JM PMID: 32969207 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 25, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Sapien 3 versus Sapien XT Balloon-expanding Valve for Transcatheter Aortic Valve Replacement: Improved Immediate and Late Outcomes at the Expense of Smaller Effective Orifice Area.
Authors: Ko YG PMID: 32969208 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 25, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Subclinical and Tiny Myocardial Injury within Upper Reference Limit of Cardiac Troponin Should Not Be Ignored after Noncardiac Surgery.
Authors: Cho SW PMID: 32969209 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 25, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Lipid and Ischemic Heart Disease Revisited: Mendelian Randomization Analysis.
Authors: Sung J PMID: 32969210 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - September 25, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease.
CONCLUSIONS: High levels LDL-C and TG were causally associated with increased IHD risk in a Korean population, these results are potentially useful as evidence of a significant causal relationship. PMID: 32812402 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Mildly Elevated Cardiac Troponin below the 99th-Percentile Upper Reference Limit after Noncardiac Surgery.
This study evaluated the association between postoperative cTn I level above the lowest limit of detection but within the 99th-percentile URL and 30-day mortality after noncardiac surgery. METHODS: Patients with cTn I values below the 99th-percentile URL during the perioperative period were divided into a no-elevation group with cTn I at the lowest limit of detection (6 ng/L) and a minor elevation group with cTn I elevation below the 99th percentile URL (6 ng/L
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Long-term Clinical Outcomes of Radiofrequency Catheter Ablation versus Permanent Pacemaker Implantation in Patients with Tachycardia-Bradycardia Syndrome.
CONCLUSIONS: RFCA is an effective alternative to PM implantation in patients with TBS. In these patients, successful RF ablation of AF is related to a higher rate of sinus rhythm maintenance compared to PM implantation, and the composite outcome of cardiovascular rehospitalization and death is similar. PMID: 32812404 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Comparing the Procedural and Clinical Outcomes of Sapien XT and Sapien 3 Valves in Transcatheter Aortic Valve Replacement in Korean Patients.
Authors: Kook H, Jang DH, Yang KS, Joo HJ, Park JH, Hong SJ, Lim DS, Choi SH, Choi YJ, Chang K, Yu CW Abstract BACKGROUND AND OBJECTIVES: The Sapien 3 (S3) valve has not been compared to the Sapien XT (SXT) valve in Korea. We compared procedural and clinical outcomes between the 2 devices. METHODS: A total of 189 patients who underwent transcatheter aortic valve replacement (TAVR) with S3 (n=95) or SXT (n=94) valve was analyzed. The primary endpoint was cardiovascular mortality at 1 year. The median follow-up duration was 438 days. RESULTS: The Society of Thoracic Surgeons score was similar between the 2 gr...
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Acute Myocarditis in Children: a 10-year Nationwide Study (2007-2016) based on the Health Insurance Review and Assessment Service Database in Korea.
CONCLUSIONS: This was the first nationwide epidemiological study to investigate acute myocarditis in Korean children. In our view, this study would help clinicians in decision-making and planning for optimal management of acute myocarditis in children. PMID: 32812406 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Long-term Clinical Outcomes of Drug-Eluting Stent Malapposition.
Authors: Lee SY, Mintz GS, Kim JS, Kim BK, Jang Y, Hong MK Abstract Previous pathologic, intravascular imaging, and clinical studies have investigated the association between adverse cardiac events and stent malapposition, including acute stent malapposition (ASM, that is detected at index procedure) and late stent malapposition (LSM, that is detected during follow-up) that can be further classified into late-persistent stent malapposition (LPSM, ASM that remains at follow-up) or late-acquired stent malapposition (LASM, newly developed stent malapposition at follow-up that was not present immediately after index st...
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Ivabradine for the Therapy of Chronic Stable Angina Pectoris.
Authors: Kim SJ PMID: 32812408 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Moderate Aortic Valve Stenosis with Left Ventricular Systolic Dysfunction: Potential Role of Early Aortic Valve Replacement.
Authors: Lee JH PMID: 32812409 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Another Unmet Need against Residual Risk of Atherosclerotic Cardiovascular Disease: Can "Thrombin Pathway" Be a New Target for Therapy?
Another Unmet Need against Residual Risk of Atherosclerotic Cardiovascular Disease: Can "Thrombin Pathway" Be a New Target for Therapy? Korean Circ J. 2020 Sep;50(9):817-821 Authors: Kim HK, Tantry US, Gurbel PA, Jeong YH PMID: 32812410 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

A Comprehensive Perspective of Clinical and Echocardiographic Features in the Differential Diagnosis of Cardiac Myxomas and Myxoma-Like Masses.
Authors: Kim DS PMID: 32812411 [PubMed] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - August 20, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Ethnic Differences in Oral Antithrombotic Therapy.
Authors: Cho H, Kang J, Kim HS, Park KW Abstract Oral antithrombotic therapy (antiplatelet therapy and anticoagulation therapy) is a key element of pharmacotherapy in patients with cardiovascular (CV) disease. Several reports of ethnic differences have suggested that there may be difference therapeutic requirements and response to therapy for antithrombotic therapy. In particular for East Asians, there seems to be a lower incidence of ischemic outcomes and a higher incidence of bleeding outcomes compared to Westerners. The purpose of this review is to describe the ethnicity-related differences in antithrombotic the...
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

CMR Parametric Mapping as a Tool for Myocardial Tissue Characterization.
Authors: Ferreira VM, Piechnik SK Abstract Cardiovascular magnetic resonance (CMR) is the current gold standard for imaging cardiac anatomy, function, and advanced myocardial tissue characterization. After cine, late gadolinium enhancement (LGE), and perfusion imaging, parametric mapping is widely regarded as the 4th era of myocardial CMR development. In contrast to conventional CMR tissue characterization techniques, which rely on relative variations in image intensities to highlight abnormal tissues, parametric mapping provides direct visualization of tissue MR properties such as T1, T2 and T2* in absolute denomi...
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Global Burden of Congenital Heart Disease: Experience in Korea as a Potential Solution to the Problem.
Authors: Lee JY PMID: 32725976 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Non-alcoholic Fatty Liver Disease, Cardio-metabolic Syndrome and Hypertension: One Concept Fits Multi-systemic Presentations.
Authors: Kim MJ PMID: 32725977 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Community-Based Pre-Hospital Electrocardiogram Transmission Program for Reducing Systemic Time Delay in Acute ST-Segment Elevation Myocardial Infarction.
Authors: Park K, Park JS, Cho YR, Park TH, Kim MH, Yang TH, Kim DI, Kim JH, Lee YH, Lee DW, Seo J, Lee GY, Kim YD Abstract BACKGROUND AND OBJECTIVES: In acute ST-segment elevation myocardial infarction (STEMI), on-site transmission of electrocardiogram (ECG) has been shown to reduce systemic time delay to reperfusion and improve outcomes. However, it has not been adopted in community-based emergency transport system in Korea. METHODS: Busan Regional Cardio-cerebrovascular Center and Busan Metropolitan City Fire and Safety Headquarters (BMFSH) jointly developed and conducted a pre-hospital ECG transmission progr...
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

A Simple Protocol to Save Time Delay for Patients with ST-Elevation Myocardial Infarction by Using Pre-hospital Electrocardiogram Transmission Program.
Authors: Cha JJ, Hong SJ PMID: 32725979 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Relationship between Waist Circumference and Cardiovascular Risk Factors in Adolescents: Analysis of the Korea National Health and Nutrition Examination Survey Data.
CONCLUSIONS: High WC in adolescents is associated with increased CVR. The timing of this association differs according to sex and CVR factors. PMID: 32725980 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Cardiovascular Risk Factors and Obesity in Adolescents.
Authors: Kim SH PMID: 32725981 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Successful Culotte Stenting for Unprotected Left Main Trifurcation Disease: Insights from Optical Coherence Tomography.
Authors: Kim Y, Kim BK, Hong SJ, Kim JS, Cho DK, Choi D, Hong MK, Jang Y PMID: 32725982 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Cardiovascular Complications of Novel Anti-Cancer Immunotherapy: Old Problems from New Agents?
Authors: Chung WB, Youn JC, Youn HJ Abstract Many novel anti-cancer therapies have dramatically improved outcomes of various cancer patients. However, it also poses a risk for cardiovascular complications as well. For the novel anti-cancer agent with which physicians does not have enough clinical experiences to determine the characteristics of cardiovascular complications, it is important to assess risk factors for cardiotoxicity before starting anti-cancer therapy. High-risk patient should be consulted to cardiologist before initiating anti-cancer therapy and pre-emptive cardiac function monitoring plan might be p...
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Cardiovascular Research Using the Korean National Health Information Database.
Authors: Choi EK Abstract The Korean National Health Information Database (NHID) contains nationwide claims data, including sociodemographic data, health care utilization, health screening data, and healthcare provider information. To compensate for the limitations of randomized clinical trials, real-world observational studies using claims data have emerged as a novel research tool. We summarized the structure of the Korean NHID and the recent researches conducted in the field of cardiovascular science. Epidemiological studies, prescription patterns, temporal trends, comparison of effectiveness and safety of treat...
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Ivabradine for the Therapy of Chronic Stable Angina Pectoris: a Systematic Review and Meta-Analysis.
CONCLUSIONS: The present work makes an important contribution to optimal patient care in angina pectoris by complementing the current European Society of Cardiology guideline-recommending class IIa with evidence level B-decisively with 8 further studies. PMID: 32725985 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Unpredictable Midterm Coronary Damage after Knuckle-reverse CART: Should We Be More Careful?
Authors: Levesque S, Gaufroy A, Gamet A, Motreff P, Christiaens LP PMID: 32725986 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

A Case of Anomalous Right Coronary Artery Infarction Mimicking ST-Segment Elevation Myocardial Infarction at the Left Anterior Descending Artery.
Authors: Beom JW, Choi JH, Boo KY, Lee JG, Kim SY, Joo SJ PMID: 32725987 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Multimodality Imaging of Large Left Ventricular Apical Pseudoaneurysm after Thoracic Surgery.
Authors: Çiçek MB, Karaduman A, Balaban İ, Kılıçgedik A, Kırma C PMID: 32725988 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Early Surgery versus Watchful Waiting in Patients with Moderate Aortic Stenosis and Left Ventricular Systolic Dysfunction.
Authors: Moon I, Kim M, Choi JW, Park JB, Hwang HY, Kim HK, Kim YJ, Kim KH, Kim KB, Sohn DW, Lee SP Abstract BACKGROUND AND OBJECTIVES: Severe aortic stenosis (AS) with left ventricular systolic dysfunction (LVSD) is a class I indication for aortic valve replacement (AVR) but this recommendation is not well established in those at the stage of moderate AS. We investigate the clinical impact of AVR among patients with moderate AS and LVSD. METHODS: From 2001 to 2017, we consecutively identified patients with moderate AS and LVSD, defined as aortic valve area 1.0-1.5 cm² and left ventricular ejection fraction
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE-/--LDLR-/- Double-Knockout Mice.
CONCLUSIONS: Direct long-term inhibition by dabigatran etexilate of thrombin led to an increase in spontaneous thrombolytic activity decreasing the expression of PAI-1 and TAFI. PMID: 32725990 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research

Long-Term Patient Prognostication by Coronary Flow Reserve and Index of Microcirculatory Resistance: International Registry of Comprehensive Physiologic Assessment.
CONCLUSION: Among patients with deferred revascularization, those with low CFR showed significantly greater risk of POCO than those with high CFR, regardless of FFR. In patients with high FFR, those with overt microvascular disease showed significantly greater risk of POCO and cardiac death or MI at 5-year, compared with the others. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03690713. PMID: 32725991 [PubMed - as supplied by publisher] (Source: Korean Circulation Journal)
Source: Korean Circulation Journal - July 30, 2020 Category: Cardiology Tags: Korean Circ J Source Type: research