Peripheral cannulae selection for veno-arterial extracorporeal life support: a paradox.
This study evaluates the precision of cannula pressure drop prediction with increase of fluid viscosity from water flow-pressure charts by M-number, dynamic similarity law, and via fitted parabolic equation. Thirteen commercially available peripheral cannulae were used in this in vitro study. Pressure drop and flow were recorded using water and a water-glycerol solution as a surrogate for blood, at ambient temperature. Subsequently, pressure-flow curves were modeled with increased fluid viscosity (0.0031 N s m-2), and then compared by M-number, dynamic similarity law, and fitted parabolic equation. The agreement of predict...
Source: Perfusion - November 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Ganushchak YM, Kurniawati ER, Maessen JG, Weerwind PW Tags: Perfusion Source Type: research

Comparison of estimation of cardiac output using an uncalibrated pulse contour method and echocardiography during veno-venous extracorporeal membrane oxygenation.
Abstract INTRODUCTION: During veno-venous extracorporeal membrane oxygenation, cardiac output monitoring is essential to assess tissue oxygen delivery. Adequate arterial oxygenation depends on the ratio between the extracorporeal pump blood flow and the cardiac output. The aim of this study was to compare estimates of cardiac output and blood flow/cardiac output ratios made using an uncalibrated pulse contour method with those made using echocardiography in patients treated with veno-venous extracorporeal membrane oxygenation. METHODS: Cardiac output was estimated simultaneously using a pulse contour method (...
Source: Perfusion - November 10, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Bond O, Pozzebon S, Franchi F, Zama Cavicchi F, Creteur J, Vincent JL, Taccone FS, Scolletta S Tags: Perfusion Source Type: research

Effect of blood viscosity on the performance of virtually wall-less venous cannulas.
CONCLUSION: Walls-less cannula showed 5.6% less pump inlet-pressure differences calculated between blood and water, as compared to that of thin-wall cannula (-21 times). Flow differences were 6% and 10% for the walls-less and thin-wall cannula respectively. We conclude that testing the cannula performance with water is a good scenario and can overestimate the flow by a 10%. However, superiority for wall-less is preserved with both water and blood. PMID: 31696777 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - November 7, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Abdel-Sayed S, Abdel-Sayed P, Berdaj D, Ferrari E, Halbe M, von Segesser LK, Maisano F Tags: Perfusion Source Type: research

Obesity is associated with worse long-term outcomes in hypertrophic cardiomyopathy patients with acute myocardial infarction.
CONCLUSION: Acute myocardial infarction and hypertrophic cardiomyopathy patients who were obese exhibited worse long-term outcomes than those without obesity. PMID: 31674878 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - November 1, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Yang J, Wang L, Sun T, Guo Q, Liu F, Zhou Y Tags: Perfusion Source Type: research

Predictive value of scoring tools in determining heparin-induced thrombocytopenia in patients on extracorporeal membrane oxygenation.
This study aims to determine the predictive value of the Warkentin 4T score, Lilo-Le Louet score, and the heparin-induced thrombocytopenia expert probability score in detecting heparin-induced thrombocytopenia in patients on extracorporeal membrane oxygenation. This was a single center, retrospective, observational cohort study of patients at Rush University Medical Center. Heparin-induced thrombocytopenia-positive patients were defined as those with an optical density greater than or equal to 0.4, consistent with a positive anti-platelet 4 heparin antibody. Out of 39 patients on extracorporeal membrane oxygenation with su...
Source: Perfusion - October 24, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Sullivan J, Bak E, Sullivan MJ, Gurnani PK Tags: Perfusion Source Type: research

Early and long-term outcomes comparing neonates, infants, and preadolescents requiring extracorporeal membrane oxygenation for heart failure.
k G Abstract BACKGROUND: Application of extracorporeal membrane oxygenation in pediatric patients with severe heart failure steadily increases. Differentiation of outcomes and survival of diverse pediatric groups is of interest for adequate therapy. METHODS: Between January 2008 and December 2016, a total of 39 pediatric patients needed veno-arterial extracorporeal membrane oxygenation support in our department. Patients were retrospectively divided into three groups: neonates (30 days/1 year). Early outcomes as well as mid- and long-term survival up to 7-year follow-up were analyzed. RESUL...
Source: Perfusion - October 14, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Sabashnikov A, Merkle J, Azizov F, Djordjevic I, Eghbalzadeh K, Tunggal I, Weber C, Weixler V, Rustenbach C, Zeriouh M, Kröner A, Wahlers T, Bennink G Tags: Perfusion Source Type: research

The selection of β-blocker after successful reperfusion in patients with ST-elevation myocardial infarction.
The selection of β-blocker after successful reperfusion in patients with ST-elevation myocardial infarction. Perfusion. 2019 Oct 14;:267659119878396 Authors: Jang HJ, Suh J, Kwon SW, Park SD, Oh PC, Moon J, Lee K, Kang WC, Jung IH, An H, Kim TH Abstract BACKGROUND: The selection of β-blocker for survivors after primary intervention due to acute ST-elevation myocardial infarction seems crucial to improve the outcomes. However, rare comparison data existed for these patients. We aimed to compare the effectiveness of selective β-blockers to that of carvedilol in patients treated with prima...
Source: Perfusion - October 14, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jang HJ, Suh J, Kwon SW, Park SD, Oh PC, Moon J, Lee K, Kang WC, Jung IH, An H, Kim TH Tags: Perfusion Source Type: research

The successful use of extra-corporeal membrane oxygenation as rescue therapy for unilateral pulmonary edema following minimally invasive mitral valve surgery.
We present in this report the successful use of extra-corporeal membrane oxygenation to manage two cases of severe hypoxia and multiorgan dysfunction secondary to unilateral right pulmonary edema. PMID: 31591929 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 8, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Goyal S, Dashey S, Zlocha V, HannaJumma S Tags: Perfusion Source Type: research

Custodiol cardioplegia solution compared to cold blood cardioplegia in pediatric cardiac surgery: a single-institution experience.
The objective of this study was to compare its impact on myocardial function in infants. METHODS: Single-center retrospective review including 132 patients
Source: Perfusion - October 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Bibevski S, Mendoza L, Ruzmetov M, Tayon K, Alkon J, Vandale B, Scholl F Tags: Perfusion Source Type: research

Hemodynamics of neonatal double lumen cannula malposition.
CONCLUSION: Rotational or translational movement of dual lumen cannula is the determining factor for atrial hemodynamics, venous capturing efficiency, blood residence time, and oxygenated blood delivery. Results obtained through computational fluid dynamics methodology can provide valuable foresight in assessing the performance of the dual lumen cannula in patient-specific configurations. PMID: 31580212 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - October 3, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jamil M, Rezaeimoghaddam M, Cakmak B, Yildiz Y, Rasooli R, Pekkan K, Salihoglu E Tags: Perfusion Source Type: research

So, you want to publish a paper . . .
PMID: 31502523 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - September 11, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Toomasian JM Tags: Perfusion Source Type: research

The Wythenshawe Hybrid Circuit for lung transplantation: a previously undescribed circuit for lung transplant.
We describe a novel circuit which allows safe and easy switch between modalities without prolonged interruption of flow. This circuit offers a safety net during surgery to minimise the risks influencing the use of extracorporeal membrane oxygenation. PMID: 31480930 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Brazier A, Seville E, Hesford W, Pate B, Exton P, Sinstadt N, Sanders M, Dosouto E, Barnard JB Tags: Perfusion Source Type: research

Haematocrit differences modify the association of cardiopulmonary bypass reoxygenation with acute kidney injury after paediatric Tetralogy of Fallot repair.
CONCLUSION: Preoperative haematocrit differences significantly modify the association of perfusate oxygenation with acute kidney injury, highlighting differential control of reoxygenation for different haematocrit children with Tetralogy of Fallot in the management of cardiopulmonary bypass. PMID: 31480951 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Liu H, Zheng SQ, Qian SC, He HH, Xue JR Tags: Perfusion Source Type: research

Perfusion management of aortic balloon occlusion technique in total arch replacement with frozen elephant trunk.
We describe the perfusion management strategy of the technique, elucidate intraoperative monitoring parameters, and clarify the feasibility of the method from the aspect of perfusion. PMID: 31480952 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Yan S, Sun X, Guo H, Li Y, Zhao Y, Shi Y, Lou S Tags: Perfusion Source Type: research

Predictors of early mortality after surgical treatment of infective endocarditis: a single-center experience.
CONCLUSION: Surgical treatment of infective endocarditis showed good results in our center. The independent predictors of 30-day postoperative mortality for patients who underwent cardiac surgery for infective endocarditis were age, body mass index, ischemic heart disease, prolonged aortic cross-clamp and cardiopulmonary bypass time, Staphylococcus aureus infection, paravalvular abscess, and septic or cardiogenic shock. PMID: 31480970 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Jakuska P, Ereminiene E, Muliuolyte E, Kosys V, Pavlavičius L, Zukovas G, Karciauskas D, Benetis R Tags: Perfusion Source Type: research

Baseline surgical status and short-term mortality after extracorporeal membrane oxygenation for post-cardiotomy shock: a meta-analysis.
Abstract OBJECTIVE: While reported mortality rates on post-cardiotomy extracorporeal membrane oxygenation vary from center to center, impact of baseline surgical status (elective/urgent/emergency/salvage) on mortality is still unknown. METHODS: A systematic search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement using PubMed/Medline databases until March 2018 using the keywords "postcardiotomy," "cardiogenic shock," "extracorporeal membrane oxygenation," and "extracorporeal life support." Relevant articles were scru...
Source: Perfusion - August 30, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Kowalewski M, Raffa G, Zieliński K, Meani P, Alanazi M, Gilbers M, Heuts S, Natour E, Bidar E, Schreurs R, Delnoij T, Driessen R, Sels JW, van de Poll M, Roekaerts P, Maessen J, Suwalski P, Lorusso R Tags: Perfusion Source Type: research

MiR-421 inhibition protects H9c2 cells against hypoxia/reoxygenation-induced oxidative stress and apoptosis by targeting Sirt3.
CONCLUSION: The miR-421-Sirt3-Jun N-terminal kinase/activator protein 1 axis is a novel molecular mechanism that accommodates hypoxia/reoxygenation-induced oxidative stress and apoptosis and provides a new direction for the study and treatment of hypoxia/reoxygenation. PMID: 31469043 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 30, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Liu Y, Qian XM, He QC, Weng JK Tags: Perfusion Source Type: research

Detection and decontamination of Mycobacterium chimaera and other non-tuberculosis mycobacteria in heater-cooler devices used in cardiopulmonary bypass: a Manufacturer and National guidelines summary, and a potential resolution to the problem requiring further investigation.
Abstract Since 2011, invasive infections due to Mycobacterium chimaera have been diagnosed in patients with previous cardiac surgery. The use of heating/cooling devices (heater-cooler units), necessary to regulate the blood temperature in extra-corporeal circulation, has been identified as a source of contaminated aerosol. Adhering to a strict maintenance program according to the manufacturer's instructions for use including sanitizing is essential to reduce the risk. Current manufacturer guidelines and national recommendations for detection and decontamination of Mycobacterium chimaera and other non-tuberculosis ...
Source: Perfusion - August 30, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Casini B, Tuvo B, Totaro M, Baggiani A, Privitera G Tags: Perfusion Source Type: research

Cardiopulmonary bypass and dual antiplatelet therapy: a strategy to minimise transfusions and blood loss.
r S Abstract BACKGROUND: Patients with preoperative dual antiplatelet therapy prior to coronary artery bypass surgery are at risk of bleeding and blood component transfusion. We hypothesise that an optimised cardiopulmonary bypass strategy reduces postoperative blood loss and transfusions. METHODS: In total, 60 patients admitted for coronary artery bypass grafting with ticagrelor and aspirin medication withdrawn
Source: Perfusion - August 24, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Karlsson M, Hannuksela M, Appelblad M, Hällgren O, Johagen D, Wahba A, Svenmarker S Tags: Perfusion Source Type: research

In-vitro performance of a low flow extracorporeal carbon dioxide removal circuit.
CONCLUSIONS: The CO2 clearance of the membrane used in this bench test is non-linear. This has implications for clinical practice, especially during the weaning phase of the device. PMID: 31441365 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 23, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Barrett NA, Hart N, Camporota L Tags: Perfusion Source Type: research

The effect of various blood management strategies on intraoperative red blood cell transfusion in first-time coronary artery bypass graft patients.
Abstract Effective blood management during cardiac surgery requires a multifactorial effort to limit exposure to allogeneic blood products. The present study evaluated the distribution of intraoperative interventions in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Records from patients undergoing non-reoperative surgery at 120 hospitals between January 2017 and December 2017 were reviewed, and red blood cell transfusion quartiles established. The 31 hospitals with the lowest transfusion rates fell into the first quartile (low transfusion group, n = 3,186 patients), while 29...
Source: Perfusion - August 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Stammers AH, Tesdahl EA, Mongero LB, Stasko A Tags: Perfusion Source Type: research

Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study.
CONCLUSION: These results suggest dexmedetomidine is extracted by the oxygenator in the extracorporeal membrane oxygenation circuit which may result in decreased drug exposure in vivo. PMID: 31431126 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Dallefeld SH, Sherwin J, Zimmerman KO, Watt KM Tags: Perfusion Source Type: research

Pneumopericardium in the neonate: a case report.
Abstract A term infant with cardiorespiratory failure treated with veno-venous extracorporeal membrane oxygenation developed pneumopericardium with cardiac tamponade while on the extracorporeal membrane oxygenation circuit. The patient was converted to veno-arterial extracorporeal membrane oxygenation and managed conservatively with spontaneous resolution of the air leak. PMID: 31416399 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 15, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Kataria-Hale J, Fernandes CJ, Speer ME Tags: Perfusion Source Type: research

Pressure-flow relationship of cannulae for extracorporeal membrane oxygenation.
PMID: 31405316 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Giani M, Lucchini A, Rona R, Capalbi S, Grasselli G, Foti G Tags: Perfusion Source Type: research

The influence of gaseous microemboli on various biomarkers after minimized cardiopulmonary bypass.
CONCLUSION: This study showed no evidence that gaseous microemboli contribute to increased biomarker levels after coronary artery bypass grafting with cardiopulmonary bypass. A reason for the absence of damage by gaseous microemboli may be the relative and considerably small amount of gaseous microemboli entering the patients in this study. PMID: 31402782 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 12, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Stehouwer MC, de Vroege R, Bruggemans EF, Hofman FN, Molenaar MA, van Oeveren W, de Mol BA, Bruins P Tags: Perfusion Source Type: research

Bleeding after cardiac surgery: multiple strategies and teamwork are essential!
PMID: 31394968 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 8, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Butt W Tags: Perfusion Source Type: research

The effect of hypothermia during cardiopulmonary bypass on three electro-encephalographic indices assessing analgesia and hypnosis during anesthesia: consciousness index, nociception index, and bispectral index.
Abstract The depth of anesthesia is commonly assessed in clinical practice by the patient's clinical signs. However, during cardiopulmonary bypass and hypothermia, common symptoms of nociception such as tachycardia, hypertension, sweating, or movement have low sensitivity and specificity in the description of the patient nociception and hypnosis, in particular, detecting nociceptive stimuli. Better monitoring of the depth of analgesia during hypothermia under cardiopulmonary bypass will avoid underdosage or overdosage of analgesia, especially opioids. Induced hypothermia has a multifactorial effect on the level of...
Source: Perfusion - August 7, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Wang X, Zhang J, Feng K, Yang Y, Qi W, Martinez-Vazquez P, Zhao G, Wang T Tags: Perfusion Source Type: research

Preoperative intra-aortic balloon pump inserted in acute myocardial infarction patients without cardiogenic shock undergoing surgical coronary revascularization.
CONCLUSION: Preoperative intra-aortic balloon pump insertion in acute myocardial infarction patients without cardiogenic shock undergoing off-pump coronary artery bypass grafting improved convalescence as shown by significantly shorter postoperative lengths of hospital stay. PMID: 31387455 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 7, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Yang F, Wang L, Hou D, Wang J, Wang X, Cui Y, Hao X, Xing Z, Jiang C, Du Z, Yang X, Miao N, Jiang Y, Xing J, Hou X Tags: Perfusion Source Type: research

Effects of the extracorporeal membrane oxygenation circuit on plasma levels of ceftolozane.
CONCLUSION: Plasma levels of ceftolozane are stable in the extracorporeal membrane oxygenation circuit, suggesting that adjustment of standard doses of ceftolozane in patients with extracorporeal membrane oxygenation support may not be needed. PMID: 31387460 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 7, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Argudo E, Riera J, Luque S, Los-Arcos I, López-Meseguer M, Sandiumenge A, Nuvials X, Grau S, Ferrer R Tags: Perfusion Source Type: research

Minimal invasive extracorporeal circulation preserves platelet function after cardiac surgery: a prospective observational study.
CONCLUSION: Cardiac surgery on minimal invasive extracorporeal circulation is a platelet preservation strategy, which contributes to the beneficial effect of minimal invasive extracorporeal circulation in coagulation integrity. PMID: 31378133 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - August 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Argiriadou H, Antonitsis P, Gkiouliava A, Papapostolou E, Deliopoulos A, Anastasiadis K Tags: Perfusion Source Type: research

Minimally invasive resection of a giant left atrial myxoma: a case report.
Abstract Cardiac tumors are a rarity. Most diagnosed primary tumors of the heart are benign, with an incidence ranging between 0.001% and 0.03%. Cardiac myxoma is one of these benign entities. A 44-year-old Caucasian woman who presented with symptoms of a common cold was diagnosed with a massive obstructing myxoma of the left atrium. Despite its large size, the tumor was completely removed using minimally invasive access through right anterior thoracotomy. However, the myxoma was adherent to the left atrial septum and was excised in toto. Pathological examinations confirmed the diagnosis of a primary cardiac myxom...
Source: Perfusion - August 1, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Gaisendrees C, Mader N, Sabashnikov A, Schlachtenberger G, Suhr L, Wahlers T Tags: Perfusion Source Type: research

Aortic root and ascending aorta dimensions in acute aortic dissection.
Abstract OBJECTIVES: Aim of this study was to evaluate ascending aorta and aortic root dimension at acute type A dissection (acute aortic dissection) and to identify demographics elements being allied to the acute event. METHODS: In a period between 2009 and 2017, 225 (n = 71, 32% female, mean age = 63 ± 12 years) patients eligible for analysis of ascending aorta and 223 (n = 70, 31% female, mean age = 63 ± 13 years) of aortic root were included in this study. Aortic diameter was assessed in preoperative computed tomography scan. The predissection diameters were modeled from the diameters obtain...
Source: Perfusion - July 31, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Koechlin L, Macius E, Kaufmann J, Gahl B, Reuthebuch O, Eckstein F, Berdajs DA Tags: Perfusion Source Type: research

Pump controlled retrograde trial off using the Cardiohelp console: safety considerations.
PMID: 31364501 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 31, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Mattke AC, Haisz E, Black A, Venugopal P Tags: Perfusion Source Type: research

Romiplostim as a transfusion saving strategy in 20 patients after heart or lung transplantation: a single centre before-after pilot study.
Abstract BACKGROUND: Thrombocytopenia is a common disorder after heart or lung transplantation. Platelet transfusion is often required to maintain haemostasis but represents a specific cause of morbidity and mortality in this setting including alloimmunisation and graft rejection. STUDY DESIGN AND METHODS: As part of a health-care quality improvement project, in a single-centre before-after pilot study, the relevance of a platelet transfusion saving strategy based on romiplostim administration after transplantation was assessed in patients with platelet count
Source: Perfusion - July 30, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Vourc'h M, Senage T, Lepoivre T, Volteau C, Fortuit C, Pattier S, Guimbretiere G, Roussel JC, Rozec B Tags: Perfusion Source Type: research

Bloodstream infection is associated with subarachnoid hemorrhage and infectious intracranial aneurysm in left ventricular assist device.
We report three left ventricular assist device recipients who presented with bloodstream infection and developed subarachnoid hemorrhage. Case 1, a 37-year-old male with non-ischemic cardiomyopathy with HeartMate II, presented with confusion and found to have serratia bloodstream infection and left frontal lobe subarachnoid hemorrhage. Cerebral angiogram showed a right M3/M4 branch infectious intracranial aneurysm. He was treated with coil embolization and underwent device exchange. Case 2, a 41-year-old male with non-ischemic cardiomyopathy with HeartMate II presented with confusion and found to have methicillin-resistant...
Source: Perfusion - July 24, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Lee T, Buletko AB, Matthew J, Cho SM Tags: Perfusion Source Type: research

Extracorporeal cardiopulmonary resuscitation in a patient with fulminant pulmonary embolism refractory to intraarrest thrombolysis.
CONCLUSION: Extracorporeal cardiopulmonary resuscitation can be used as a salvage therapy in patients with fulminant pulmonary embolism in whom intraarrest thrombolysis has failed. PMID: 31328640 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Thind GS, Hanane T, Bribriesco A, Yun J, Anandamurthy B, Latifi M, Unai S, Krishnan S Tags: Perfusion Source Type: research

Reversible right heart failure after redo operation of a post-traumatic Gerbode defect.
CONCLUSION: We strongly recommend that in cardiac areas where high wall tension is applied, durable materials such as Dacron should be used. We also believe that a well-documented discussion with the patient, about his medical condition and his therapeutic alternatives, is imperative. PMID: 31328690 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Fragoulis S, Contrafouris C, Thanopoulos A, Kyriakoulis K, Apostolopoulou S Tags: Perfusion Source Type: research

Deep hypothermic extracorporeal membrane oxygenation cannula exchange in a child with necrotic pneumonia.
We present a case of a child initially placed on veno-arterial extracorporeal membrane oxygenation and converted to veno-venous extracorporeal membrane oxygenation. This was done under deep hypothermia in the operating theater. PMID: 31303113 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Martens T, Saini R, Crook R, Robertson A, Muthialu N, Brown K Tags: Perfusion Source Type: research

A skills acquisition study on ECMOjo: a screen-based simulator for extracorporeal membrane oxygenation.
CONCLUSION: The present findings show no significant dissimilarities between ECMOjo and didactic classroom-based teaching. Both methods are very comparable in terms of the learner's reported self-efficacy and complementary to mannequin-based simulations. PMID: 31303136 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Alsalemi A, Tanaka L, Ogino M, Disi MA, Alhomsi Y, Bensaali F, Amira A, Alinier G Tags: Perfusion Source Type: research

Sedation with alfentanil versus fentanyl in patients receiving extracorporeal membrane oxygenation: outcomes from a single-centre retrospective study.
CONCLUSIONS: No differences in patient outcomes were found between extracorporeal membrane oxygenation patients sedated with alfentanil compared with fentanyl. There was a statistically significant reduction in some adjunctive sedatives in patients managed with a fentanyl-based regimen. Prospective studies are required to confirm these results. PMID: 31296116 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 12, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Barker M, Dixon AA, Camporota L, Barrett NA, Wan RYY Tags: Perfusion Source Type: research

Comparing in-patient extracorporeal cardiopulmonary resuscitation to standard cardiac treatment group of extracorporeal membrane oxygenation patients: 8  years of experience at a single institution.
CONCLUSION: Over years of experience with extracorporeal membrane oxygenation, the outcome of the extracorporeal cardiopulmonary resuscitation has been improving and appears to exceed those of traditional methods, despite limited sample size. Neurological complications still need to be addressed in order for survival and outcomes to improve. PMID: 31296118 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - July 12, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Liem S, Cavarocchi NC, Hirose H Tags: Perfusion Source Type: research

Dishonesty in science.
PMID: 31234754 [PubMed - in process] (Source: Perfusion)
Source: Perfusion - June 28, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Lockwood G Tags: Perfusion Source Type: research

Differences of early immunological responses in on-pump versus off-pump cardiac surgery.
This study investigated the early response of peripheral blood cell types and early changes in lung tissue in on-pump versus off-pump cardiopulmonary bypass surgery. METHODS: Landrace pigs were assigned to the following groups (n = 6 per group): 1. off-pump cardiopulmonary bypass, 2. conventional cardiopulmonary bypass, 3. heparin-coated cardiopulmonary bypass, 4. surface-reduced cardiopulmonary bypass, and 5. surface-reduced cardiopulmonary bypass plus lung perfusion. Surgery was performed under mild hyperthermia (32°C), with 90-minute ischemia and 180-minute reperfusion. Histological and flow cytom...
Source: Perfusion - June 28, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Lehmann S, Dieterlen MT, Flister A, Klaeske K, Jawad K, Garbade J, Borger MA, Kostelka M Tags: Perfusion Source Type: research

Selective brain hypothermia: feasibility and safety study of a novel method in five patients.
CONCLUSION: The NeuroSave system can induce rapid brain-targeted hypothermia and simultaneously maintain a favorable body-brain temperature gradient, even during hypotension. Further studies are required to evaluate the function of the system during longer periods of use. PMID: 31238794 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - June 26, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Seyedsaadat SM, Marasco SF, Daly DJ, McEgan R, Anderson J, Rodgers S, Kreck T, Kadirvel R, Kallmes DF Tags: Perfusion Source Type: research

Distal limb perfusion cannula in peripheral extracorporeal membrane oxygenation: always a mandatory approach?
PMID: 31223058 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Formica F, D'Alessandro S, Sangalli F, Avalli L Tags: Perfusion Source Type: research

Use of bivalirudin as a primary anticoagulant in a child during Berlin Heart EXCOR ventricular assist device support.
We describe our experience of bivalirudin use, a newer direct thrombin inhibitor, in an infant who was supported with Berlin Heart EXCOR VAD (Berlin VAD) as bridge to transplant for 122 days without complications and without need for pump exchange. An 11-month-old girl with dilated cardiomyopathy with acute heart failure was awaiting cardiac transplant. Lack of improvement despite maximizing medical therapy and anticipating a prolonged waitlist time, she was supported with Berlin LVAD as a bridge to transplant. Anticoagulation with bivalirudin was started and titrated with a goal partial thromboplastin time of 60-90...
Source: Perfusion - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Medar SS, Hsu DT, Lamour JM, Bansal N, Peek GJ Tags: Perfusion Source Type: research

An urgent open surgical approach for left ventricle venting during peripheral veno-arterial extracorporeal membrane oxygenation for refractory cardiac arrest: case report.
We report the use of a surgical approach with sternotomy for left ventricle venting in a 21-year-old patient who was placed under veno-arterial extracorporeal membrane oxygenation for refractory cardiac arrest with severe pulmonary edema, respiratory failure, and left ventricle stasis. A 21-year-old woman was admitted for laparoscopic sleeve gastrectomy. In the recovery room, she developed a refractory circulatory shock. Transthoracic echocardiography revealed a dilated cardiomyopathy with severe left ventricle systolic dysfunction (left ventricle ejection fraction at 20%). Coronary angiogram was normal. On day 2, she unde...
Source: Perfusion - June 20, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Beyls C, Huette P, Guilbart M, Nzonzuma A, Abou Arab O, Mahjoub Y Tags: Perfusion Source Type: research

Antithrombin supplementation in adult patients receiving extracorporeal membrane oxygenation.
Abstract INTRODUCTION: Extracorporeal membrane oxygenation is associated with an increased risk of thrombosis and hemorrhage. Acquired antithrombin deficiency often occurs in patients receiving extracorporeal membrane oxygenation, necessitating supplementation to restore adequate anticoagulation. Criteria for antithrombin supplementation in adult extracorporeal membrane oxygenation patients are not well defined. METHODS: In this retrospective observational study, adult patients receiving antithrombin supplementation while supported on extracorporeal membrane oxygenation were evaluated. Antithrombin was supple...
Source: Perfusion - June 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Morrisette MJ, Zomp-Wiebe A, Bidwell KL, Dunn SP, Gelvin MG, Money DT, Palkimas S Tags: Perfusion Source Type: research

Debranching-first and proximal arch replacement for an innominate artery aneurysm: a case study.
We describe the debranching-first technique and proximal arch replacement for a huge innominate artery aneurysm and discuss the surgical strategy for cannulation, perfusion and organ protection. PMID: 31203765 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - June 15, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Lazopoulos G, Kalogerakos PD, Pavlopoulos D, Chaniotaki F, Dermitzaki D, Kokotsakis J Tags: Perfusion Source Type: research

miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway.
CONCLUSION: This study has found that knockdown of miR-33-5p induced ABCA1 expression and promoted inflammatory cytokines and cholesterol efflux likely via activating the PI3K/Akt signaling pathway. PMID: 31170866 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - June 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Zhao L, Huang J, Zhu Y, Han S, Qing K, Wang J, Feng Y Tags: Perfusion Source Type: research