Long non-coding RNA AK001903 regulates tumor progression in cervical cancer.
In conclusion, lncRNA-AK001903 was demonstrated to be an oncogenic lncRNA that promotes tumor progression and may be an effective target for CC treatment in the near future. PMID: 33363614 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prognostic role of matrix metalloproteinase 9 in early breast cancer.
Authors: Kalavska K, Cierna Z, Karaba M, Minarik G, Benca J, Sedlackova T, Kolekova D, Mrvova I, Pindak D, Mardiak J, Mego M Abstract MMP9 is involved in extracellular matrix degradation during various physiological and pathological conditions, including tumorigenesis. The present study aimed to assess the prognostic role of intratumoral MMP9 and to determine its association with circulating tumor cells (CTCs) in patients with early breast cancer. A total of 318 patients with primary breast cancer (PBC) were enrolled into the present study. Specimens were subjected to immunohistochemistry analysis, using the MMP9 m...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Abnormally high HIP1 expression is associated with metastatic behaviors and poor prognosis in ESCC.
Authors: Sun Y, Zhou Y, Xia J, Wen M, Wang X, Zhang J, Zhang Y, Zhang Z, Jiang T Abstract Huntingtin interacting protein 1 (HIP1) is overexpressed in several human malignancies. However, the biological function of HIP1 in esophageal squamous cell carcinoma (ESCC), and its effect on the prognosis of patients remain unclear. The present study aimed to investigate HIP1 expression in ESCC via immunohistochemistry, reverse transcription-quantitative PCR and western blot analyses. The association between HIP1 expression and the clinicopathological characteristics of 173 patients with ESCC was statistically analyzed. The ...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA SNHG9 inhibits ovarian cancer progression by sponging microRNA-214-5p.
Authors: Chen GY, Zhang ZS, Chen Y, Li Y Abstract Ovarian cancer ranks 7th among the most common cancer types affecting women worldwide. A number of studies have confirmed that multiple long non-coding RNAs participate in the occurrence and progression of ovarian cancer. Small nucleolar RNA host gene 9 (SNHG9) serves a role in the progression of glioblastoma and pancreatic cancer. However, the specific biological function of SNHG9 in ovarian cancer has not yet been fully investigated. The present study aimed to determine the biological role and potential molecular mechanism underlying the influence of SNHG9 in ovar...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Nuclear factor I/B mediates epithelial-mesenchymal transition in human melanoma cells through ZEB1.
Authors: Cheng R, Gao S, Hu W, Liu Y, Cao Y Abstract The relationship between nuclear factor I/B (NFIB) and cancer attracts growing research interest. NFIB has diverse and specific roles in tumor progression and invasion. However, the potential effects and functions of this transcription factor in melanoma remain unclear. The present study sought to determine the distinguishing properties of NFIB in melanoma cells. Immunohistochemical examination of the tissues of 15 patients with melanoma indicated that the expression of NFIB was high in melanoma specimens, compared with the benign nevus and normal skin specimens....
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1.
Authors: Guo L, Zheng J, Zeng H, Zhang Z, Shao G Abstract Atorvastatin is a competitive inhibitor of β-hydroxy β-methylglutaryl-CoA reductase, which is involved in anticancer effects in numerous types of cancer, including in human liver cancer. However, its functions and underlying mechanisms of chemosensitivity in liver cancer remain to be elucidated. The present study investigated the effect of atorvastatin on cisplatin chemosensitivity and its molecular mechanisms, with a focus on the Yes1-associated transcriptional regulator (YAP1) protein. The present study demonstrated that atorvastatin significantl...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Erratum: TGF- β induces growth suppression in multiple myeloma MM.1S cells via E2F1.
Erratum: TGF-β induces growth suppression in multiple myeloma MM.1S cells via E2F1. Oncol Lett. 2021 Feb;21(2):83 Authors: Liu X, Guo H, Wei Y, Cai C, Zhang B, Li J Abstract [This corrects the article DOI: 10.3892/ol.2017.6360.]. PMID: 33363620 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound.
Authors: Zhao J, Zhou H, An Y, Shen K, Yu L Abstract Accumulating evidence has indicated that corosolic acid exerts anti-diabetic, anti-obesity, anti-inflammatory, anti-hyperlipidemic and anti-viral effects. More importantly, corosolic acid has recently attracted much attention due to its anticancer properties and innocuous effects on normal cells. Furthermore, the increasing proportion of obese and/or diabetic populations has led to an epidemic of non-alcoholic fatty liver disease (NAFLD), which frequently progresses to hepatocellular carcinoma (HCC). Evidence has indicated that NAFLD is closely associated with th...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of matrine in combination with cisplatin on liver cancer.
Authors: Hu G, Cao C, Deng Z, Li J, Zhou X, Huang Z, Cen C Abstract Matrine, an alkaloid isolated from Sophora flavescens, promotes tumor cell apoptosis and strengthens the anticancer capacity of chemotherapeutic drugs. The present study aimed to investigate the inhibitory effect and underlying mechanism of matrine in combination with cisplatin on liver cancer progression. Tumor progression was studied in nude mice. The human liver cancer cell line HepG2 was injected into BALB/c nude mice subcutaneously to establish a tumor model. Mice were subsequently treated with matrine, cisplatin, matrine + cisplatin or normal...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells.
Authors: Ma T, Guo R, Wang X, Shen WT, Zhu M, Jin YN, Xu HP Abstract The presence of hypoxia in solid tumors is considered one of the major factors that contribute to radiation resistance. The aim of the present study was to establish a therapeutic system, which can be controlled by radiation itself, to enhance radiosensitivity. For this purpose, a lentiviral gene therapy vector containing the human inhibitor of growth 4 (ING4) and its upstream promoter, human early growth response factor-1 (EGR1), which possesses the radiation-inducible characteristics to activate the transcription of its downstream genes, was con...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Post-radiation circulating tumor DNA as a prognostic factor in locally advanced esophageal squamous cell carcinoma.
Authors: Jia R, Zhao CH, Li PS, Liu RR, Zhang Y, Chen HE, Chang LP, Gong YH, Guan YF, Yi X, Xu JM Abstract Esophageal squamous cell carcinoma (ESCC) is a highly malignant and deadly tumor. Radiation therapy is one of the primary treatments for locally advanced ESCC. However, the biomarkers for prognosis of definitive radiation remain undefined. Peripheral blood circulating tumor (ct)DNA provides information of tumor genetic alterations and has been confirmed as a potential non-invasive biomarker for several types of cancer. The present study investigated the clinical implications of ctDNA detection in patients with...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High expression of HVEM is associated with improved prognosis in intrahepatic cholangiocarcinoma.
Authors: Ma B, Meng H, Tian Y, Wang Y, Song T, Zhang T, Wu Q, Cui Y, Li H, Zhang W, Li Q Abstract Herpesvirus entry mediator (HVEM) displays dual signals in T-cell activation according to the ligands and intracytoplasmic effectors it interacts with. High HVEM expression may play an immunosuppressive role in several malignancies. The present study investigated the clinical impact of HVEM on intrahepatic cholangiocarcinoma (ICC), including its prognostic value, and association with clinicopathological features and immune status. The clinical data of 102 consecutive patients with ICC who underwent surgical treatment f...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Proliferation, migration and invasion of triple negative breast cancer cells are suppressed by berbamine via the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways.
Authors: Liu L, Yan J, Cao Y, Yan Y, Shen X, Yu B, Tao L, Wang S Abstract Breast cancer is the second most common cause of cancer-associated mortality among women worldwide, and triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Berbamine (BBM) is a traditional Chinese medicine used for the treatment of leukopenia without any obvious side effects. Recent reports found that BBM has anti-cancer effects. The present study aimed to investigate the effects of BBM on TNBC cell lines and the underlying molecular mechanism. MDA-MB-231 cells and MCF-7 cells, two TNBC cell lines, were treat...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane.
Authors: Iida Y, Okamoto-Katsuyama M, Maruoka S, Mizumura K, Shimizu T, Shikano S, Hikichi M, Takahashi M, Tsuya K, Okamoto S, Inoue T, Nakanishi Y, Takahashi N, Masuda S, Hashimoto S, Gon Y Abstract Small-cell lung cancer (SCLC) is a highly aggressive cancer with poor prognosis, due to a lack of therapeutic targets. Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables and has shown anticancer effects against numerous types of cancer. However, its anticancer effect against SCLC remains unclear. The present study aimed to demonstrate the anticancer effects of SFN in SCLC cells by investigating...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma.
Authors: Zhao L, Liu SY, Li YM, Xiong ZT Abstract Colorectal cancer (CRC) is a common malignant tumor of digestive system. CRC with micropapillary pattern (MPP) is an aggressive variant of colorectal adenocarcinoma. The aim of the present study was to clarify the clinicopathological significance and the prognostic role of an immunohistochemical marker, MPP, in CRC. The association between MPP and clinicopathological characteristics and prognosis in 286 cases of CRC (286/453 cases had follow-up information) were analysed. Then, 81 tissues without MPP and 90 tissues with MPP were analysed by immunohistochemistry usin...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Correlation analysis of serum cystatin C, uric acid and lactate dehydrogenase levels before chemotherapy on the prognosis of small-cell lung cancer.
Authors: Wang H, Shan D, Dong Y, Yang X, Zhang L, Yu Z Abstract Related studies have reported that cystatin C (Cys C), uric acid (UA) and lactate dehydrogenase (LDH) affect tumor growth and invasion; however, the correlation between them and the prognosis of patients with small-cell lung cancer (SCLC) remains unclear. The present study aimed to investigate the effects of serum Cys C, UA and LDH concentrations on the prognosis of patients with SCLC prior to initial treatment, in order to identify potential targets for determining the clinical outcome of patients with SCLC. A total of 205 patients with SCLC were enro...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prognosis of segmentectomy in the treatment of stage IA non-small cell lung cancer.
Authors: Bai W, Li S Abstract With improvements in detection technology, increasing numbers of patients with non-small cell lung cancer (NSCLC) are being diagnosed at an early stage. In order to treat the illness with minimal invasion and preserve lung function to the greatest possible extent, there has been an increasing tendency towards treating early-stage NSCLC by segmentectomy. However, questions remain regarding whether patients may benefit from this procedure considering the surgical and oncological outcomes. Whether adequate margin distance and lymph node dissection may be achieved is one of the most import...
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Circular dumbbell miR-34a-3p and -5p suppresses pancreatic tumor cell-induced angiogenesis and activates macrophages.
In conclusion, the present study demonstrates an approach for blocking angiogenesis using db34a. The data also show that this approach may be used to targeting multiple molecules and pathways. PMID: 33365086 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of rhophilin 2 promotes pancreatic ductal adenocarcinoma.
In conclusion, the present study demonstrated that RHPN2 may promote PDAC making it a potential candidate for targeted therapy. PMID: 33365087 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 30, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Abnormal expression of HNRNPA3 in multistep hepatocarcinogenesis.
Authors: Ren X, Dong Y, Duan M, Zhang H, Gao P Abstract Hepatocarcinogenesis is a multistep process involving progression from cirrhosis, to low-grade dysplastic nodule, to high-grade dysplastic nodule (HGDN) and, eventually, to hepatocellular carcinoma (HCC). Early detection of HCC is challenging as the differential diagnosis between HGDN and early HCC (eHCC) is difficult. The aim of the present study was to identify a novel biomarker to specifically differentiate between HGDN and eHCC, which may facilitate early diagnosis of HCC. Immunohistochemistry was performed to determine the expression of heterogeneous nucl...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Fibrinogen-like protein 2 promotes the accumulation of myeloid-derived suppressor cells in the hepatocellular carcinoma tumor microenvironment.
Authors: Liu BQ, Bao ZY, Zhu JY, Liu H Abstract The tumor microenvironment in hepatocellular carcinoma can be classified into cellular and non-cellular components. Myeloid-derived suppressor cells (MDSCs) are cellular components of this microenvironment that serve an important role in the progression of hepatocellular carcinoma. Fibrinogen-like protein 2 (FGL2) has been demonstrated to promote tumor progression by regulating cellular components of the tumor microenvironment in various types of malignant tumor. The present study aimed to determine the expression of FGL2 in hepatocellular carcinoma and its effect on ...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Role of tesmin expression in non-small cell lung cancer.
Authors: Grzegrzolka J, Olbromski M, Gomulkiewicz A, Piotrowska A, Glatzel-Plucinska N, Ratajczak K, Sputa-Grzegrzolka P, Rzechonek A, Werynska B, Podhorska-Okolow M, Dziegiel P Abstract Non-small cell lung cancer (NSCLC) is the most commonly diagnosed cancer and the most frequent cause of cancer-associated mortality worldwide. Tesmin (MTL5) is a 60 kDa protein which has cysteine rich motifs, characteristic of metallothioneins. Tesmin expression was first observed in germ cells during spermatogenesis. Increased tesmin expression in NSCLC has been described previously. Minichromosome maintenance proteins (MCMs) serv...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of an antitumor effect of demethylzeylasteral on human gastric cancer cells.
Authors: Yang Y, Zhao M, Hu T, Su F, Qian F, Wang Z Abstract Gastric cancer is a common malignancy in China, with the second highest mortality rate worldwide. Advanced gastric cancer usually exhibits a poor prognosis with a low 5-year survival rate. Therefore, developing novel drugs for the treatment of this cancer will be beneficial for patients. Demethylzeylasteral, an extract of tripterygium wilfordii, has shown positive anticancer activities. However, the possible antitumor effect of demethylzeylasteral on gastric cancer cells and its underlying molecular mechanism remain to be determined. In the present study,...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Integrated analysis of microRNA and transcription factors in the bone marrow of patients with acute monocytic leukemia.
Authors: Lin XC, Yang Q, Fu WY, Lan LB, Ding H, Zhang YM, Li N, Zhang HT Abstract Acutemonocytic leukemia (AMoL) is a distinct subtype of acute myeloid leukemia (AML) with poor prognosis. However, the molecular mechanisms and key regulators involved in the global regulation of gene expression levels in AMoL are poorly understood. In order to elucidate the role of microRNAs (miRNAs/miRs) and transcription factors (TFs) in AMoL pathogenesis at the network level, miRNA and TF expression level profiles were systematically analyzed by miRNA sequencing and TF array, respectively; this identified 285 differentially expres...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical characteristics and outcomes of 17 cases of inflammatory myofibroblastic tumor at a University Hospital in China.
Authors: Song W, Zhu Y Abstract The aim of the present study was to explore the clinical and pathological characteristics, diagnosis, and treatment of inflammatory myofibroblastic tumor (IMT). A total of 17 patients with IMT diagnosed between July 2010 and February 2020 were included in the present study, and the clinical characteristics, pathological features, treatment and prognosis were analyzed retrospectively. The cohort consisted of 17 participants, including 12 men and 5 women, with a mean age of 34.76 years. The most common locations of tumors were the bronchi and the lungs (9 cases, including 1 case involv...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Nidogen 1 regulates proliferation and migration/invasion in murine claudin-low mammary tumor cells.
Authors: Jagroop R, Martin CJ, Moorehead RA Abstract Nidogen 1 (NID1) is a glycoprotein found in basement membranes involved in cross-linking collagen IV and laminin. The role of NID in breast cancer has only been evaluated in a small number of studies and the findings of these studies have been inconsistent. Our previous work revealed that highly tumorigenic murine mammary tumor cells express high levels of Nid1 while weakly tumorigenic mammary tumor cells express low levels of Nid1. To investigate Nid1, two stable knockdown lines were created, and Nid1 knockdown was confirmed at both the mRNA and protein level. N...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

LINC00565 promotes the progression of colorectal cancer by upregulating EZH2.
Authors: Shao X, Zhao T, Xi L, Zhang Y, He J, Zeng J, Deng L Abstract The present study aimed to illustrate the role of LINC00565 in aggravating colorectal cancer (CRC) by targeting enhancer of zeste homolog 2 (EZH2). The relative levels of LINC00565 and EZH2 in CRC tissues, based on their Tumor-Node-Metastasis stage and tumor size, were detected by reverse transcription-quantitative polymerase chain reaction. The diagnostic value of LINC00565 in CRC was assessed by depicting receiver operating characteristic curves. Pearson's correlation test was applied to analyze the expression correlation between LINC00565 and ...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Circulating exosomal miR-125a-5p as a novel biomarker for cervical cancer.
Authors: Lv A, Tu Z, Huang Y, Lu W, Xie B Abstract Exosomal microRNAs (miRs/miRNAs) have been reported to be associated with cervical cancer. The aim of the present study was to investigate circulating exosomal miRNA as a biomarker for cervical cancer diagnosis. In the present study, samples from 6 patients with cervical cancer and 6 healthy control subjects were retrieved for exosomal RNA-sequencing. The results revealed that a total of 39 miRNAs were differentially expressed between patients with cervical cancer and healthy controls (P2.0). Exosomal miR-125a-5p was further quantified in plasma from 60 subjects, w...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of APRIN expression increases cancer cell proliferation via an interleukin-6/STAT3/cyclin D axis.
Authors: Sohn MS, Kang M, Kang SM, Bae S Abstract APRIN is a putative tumor suppressor whose expression is low in a variety of cancer cells. While decreased expression of APRIN leads to increased cell proliferation, unfavorable diagnosis or metastases in various cancer types, there is limited knowledge on the cellular mechanism of APRIN in cellular responses. The effect of APRIN depletion on cancer cell proliferation was examined in the present study, and the IL-6/STAT3/cyclin D axis was identified as a novel regulatory mechanism. Stable depletion of APRIN in cancer cells resulted in increased cell proliferation. C...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Soluble CD40 ligand inhibits the growth of non-Hodgkin's lymphoma cells through the JNK signaling pathway.
Authors: Feng Z, Wang J Abstract The incidence of non-Hodgkin's lymphoma (NHL) has been increasing annually and has become a serious threat to human health. However, the pathogenesis of NHL remains unclear. The present study aimed to investigate the effect of soluble CD40 ligand (sCD40L) on NHL cells and its underlying mechanism. Cell Counting kit-8 assay and flow cytometry apoptosis experiments were conducted to investigate the effects of sCD40L on cell proliferation and apoptosis. Western blotting was performed to detect the protein expression levels of BAX, Bcl-2, ERK, p-ERK, JNK, p-JNK, p38, p-p38 and c-JUN. Th...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Innate immune cells and their interaction with T cells in hepatocellular carcinoma.
Authors: Hong GQ, Cai D, Gong JP, Lai X Abstract Hepatocellular carcinoma (HCC) is a malignant tumor and is associated with necroinflammation driven by various immune cells, such as dendritic cells, macrophages and natural killer cells. Innate immune cells can directly affect HCC or regulate the T-cell responses that mediate HCC. In addition, innate immune cells and T cells are not isolated, which means the interaction between them is important in the HCC microenvironment. Considering the current unsatisfactory efficacy of immunotherapy in patients with HCC, understanding the relationship between innate immune cell...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma.
In conclusion, hsa_circ_0005114-miR-142-3p/miR-590-5p-APC ceRNA axes may be potential targets for the treatment of glioma. PMID: 33281969 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Authors: Wang P, Wang C, Liu C Abstract Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell line were investigated, MTT, colony formation, Transwell, wound-healing, TUNEL, Comet, immunofluorescence and western blot assays were used to assess the effects of dioscin on A431 cells. The results of MTT, colony formation, Transwell and wound-healing assays revea...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of key genes in lung adenocarcinoma based on a competing endogenous RNA network.
Authors: Song Z, Zhang Y, Chen Z, Zhang B Abstract Lung adenocarcinoma (LUAD) is the most commonly diagnosed type of lung cancer and exhibits a high morbidity. The present study aimed to investigate the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) mechanisms in LUAD. The receptor activity modifying protein 2-antisense RNA 1 (RAMP2-AS1) was identified using GSE113852 and GSE130779 datasets downloaded from the Gene Expression Omnibus database, and the downregulation of RAMP2-AS1 was the most significant in LUAD. In addition, microRNA (miR)-296-5p was identified to bind to RAMP2-AS1 via bio...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Crizotinib changes the metabolic pattern and inhibits ATP production in A549 non-small cell lung cancer cells.
Authors: Ye S, Zhou HB, Chen Y, Li KQ, Jiang SS, Hao K Abstract Crizotinib, an inhibitor of the hepatocyte growth factor receptor oncogene, has been studied extensively regarding its antitumor and clinically beneficial effects in non-small cell lung cancer (NSCLC). However, crizotinib's effects on cancer cell energy metabolism, which is linked with tumor proliferation and migration, in NSCLC are unclear. Therefore, the present study focused on crizotinib's effect on NSCLC glucose metabolism. Crizotinib's effects on glucose metabolism, proliferation, migration and apoptosis in A549 cells were explored. Several other...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration-resistant prostate cancer.
Authors: Hu M, Ning J, Mao L, Yu Y, Wu Y Abstract Castration-resistant prostate cancer (CRPC) treatment still remains difficult. The aim of the present study was to determine the antitumour efficacy of the MutT homolog 1 (MTH1) inhibitor, TH1579, against castration-resistant prostate cancer. PC-3 and DU-145 prostate cancer cells were treated with different concentrations of TH1579. C4-2 cells with or without androgen receptor (AR) were also treated with TH1579 to assess AR function. Cell survival, 8-oxo-dG levels and DNA damage were measured using cell viability assays, western blotting, immunofluorescence analysis...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The expression of trefoil factor 3 is related to histologic subtypes and invasiveness in lung adenocarcinoma.
Authors: Luo W, Tahara S, Kawasaki K, Kobayashi A, Nojima S, Morii E Abstract Adenocarcinoma is the most common histological type of lung cancer and has various histologic subtypes, including lepidic, papillary, acinar and invasive mucinous adenocarcinoma. Histologic subtypes are associated with tumor invasiveness. For example, the lepidic subtype is less invasive than the papillary/acinar subtype. Trefoil factor 3 (TFF3) is a small secreting protein that is a member of the trefoil factor family, which is involved in mucosal stabilization and repair through its mitogenic and antiapoptotic activities. TFF3 overexpre...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Histone deacetylase 6 inhibition in urothelial cancer as a potential new strategy for cancer treatment.
Authors: Kuroki H, Anraku T, Kazama A, Shirono Y, Bilim V, Tomita Y Abstract Histone deacetylases (HDACs) are enzymes that remove acetyl groups from histones and have attracted attention as potential targets for cancer therapy. Several small molecule inhibitors have been developed to target HDACs; however, clinical trials of pan-HDAC inhibitors have found these types of inhibitors to be inefficient and to be relatively highly toxic. In the present study, the role of one HDAC isozyme, HDAC6, in urothelial cancer was investigated. Protein expression levels and subcellular localization of HDAC6 was identified in surgi...
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells.
In conclusion, neither MCF-7 nor T47D breast cancer cells were affected by BHB during glucose deprivation; however, screening of tumors for activation of ketone body-metabolizing enzymes may be able to identify patients that will benefit from ketogenic diet interventions. PMID: 33281976 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 9, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1 α/PKM2/STAT3 pathway.
Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway. Oncol Lett. 2021 Jan;21(1):31 Authors: Yin W, Liu Y, Liu X, Ma X, Sun B, Yu Z Abstract Epithelial-mesenchymal transition (EMT) serves an important role in the formation and development of various types of cancer, including oral squamous cell carcinoma (OSCC). Metformin, used for treating type 2 diabetes, has been revealed to exert an anticancer effect in various types of cancer, including liver, breast and colorectal cancer. However, its role in the EMT of OSCC has been rar...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Autophagy and apoptosis induction by sesamin in MOLT-4 and NB4 leukemia cells.
Authors: Deesrisak K, Chatupheeraphat C, Roytrakul S, Anurathapan U, Tanyong D Abstract Sesamin, the major furofuran lignan found in the seeds of Sesamum indicum L., has been investigated for its various medicinal properties. In the present study, the anti-leukemic effects of sesamin and its underlying mechanisms were investigated in MOLT-4 and NB4 acute leukemic cells. Leukemic cells were treated with various concentrations of sesamin. Cell viability was determined using an MTT assay. Flow cytometry using Annexin V-FITC/PI staining and anti-LC3/FITC antibodies was applied to detect the level of apoptosis and autop...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-4636 inhibits tumor cell proliferation, migration and invasion, and serves as a candidate clinical biomarker for gastric cancer.
Authors: Tang J, Hu Y, Zhang C, Gong C Abstract Gastric cancer (GC) is one of the most common malignancies with a high worldwide incidence rate. The association between microRNAs (miRs) and malignancy has been widely studied in recent years. The aim of the present study was to assess the clinical value of miR-4636 in patients with GC and its effect on the proliferation, migration and invasion of GC cells. Reverse transcription-quantitative PCR was used to detect the expression of miR-4636. Receiver operating characteristics curve, Kaplan-Meier survival curve and Cox regression analyses were used to evaluate the dia...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum.
Authors: Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P Abstract The Traditional Chinese Medicine, Ganoderma lucidum, has been widely used for its immunity-related and anti-cancer effects. Fudan-Yueyang-Ganoderma lucidum (FYGL) is a proteoglycan, extracted from Ganoderma lucidum, that has shown safe anti-diabetic activity in vivo. The present study demonstrated that FYGL could selectively inhibit the viability of PANC-1 and BxPC-3 pancreatic cancer cells in a dose dependent manner, but not in Mia PaCa-2 pancreatic cancer cells and HepG2 liver cancer cells. In addition, FYGL could...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-126: A new and promising player in lung cancer.
Authors: Chen Q, Chen S, Zhao J, Zhou Y, Xu L Abstract Lung cancer is one of the most common malignant tumors associated with cancer death; however, the mechanisms involved in lung tumor development have not been completely elucidated, which impedes the advancement of clinical diagnosis and therapy. MicroRNA-126 (miR-126) is an important member of the microRNA family and is encoded by intron 7 of epidermal growth factor-like domain-containing gene 7. Increasing evidence has demonstrated that miR-126, as a distinct endothelial-enriched miRNA and new tumor suppressor gene, serves a promising role in the occurrence, d...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

CD204-positive macrophages accumulate in breast cancer tumors with high levels of infiltrating lymphocytes and programmed death ligand-1 expression.
In conclusion, 22% of BC tumors were classified as TIL+PD-L1+ (69% were TN), which were enriched with suppressive immune subsets. These cell types may serve as potential novel immunotherapeutic targets. PMID: 33262828 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression levels of FBXW7 and MDM2 E3 ubiquitin ligases and their c-Myc and p53 substrates in patients with dysplastic nevi or melanoma.
Authors: Mozuraitiene J, Gudleviciene Z, Vincerzevskiene I, Laurinaviciene A, Pamedys J Abstract E3 ubiquitin ligases are of interest as drug targets due to their involvement in the regulation of the functions and interactions of several proteins. Various E3 ligase complexes are considered oncogenes or tumor suppressors associated with the development of melanoma. These proteins regulate the functions of various signaling pathways and proteins, such as p53 and Notch. The aim of the present study was to determine the expression levels of F-box and WD repeat domain-containing 7 (FBXW7), c-Myc, MDM2 and p53 proteins i...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

SDF1 α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment.
SDF1α/CXCR4 axis may be associated with the malignant progression of gastric cancer in the hypoxic tumor microenvironment. Oncol Lett. 2021 Jan;21(1):38 Authors: Yashiro M, Kinoshita H, Tsujio G, Fukuoka T, Yamamoto Y, Sera T, Sugimoto A, Nishimura S, Kushiyama S, Togano S, Kuroda K, Toyokawa T, Ohira M Abstract Stromal cell-derived factor 1α (SDF1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B-cell lymphoma by counteracting miR-331-3p expression.
In conclusion, the present findings firstly demonstrated that UCA1 silencing restrained DLBCL cell proliferation and metastases viability by suppressing miR-331-3p expression. It is suggested that UCA1 could be a possible medicinal target and biomarker for DLBCL. PMID: 33262831 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of CTEN is associated with gefitinib resistance in non-small cell lung cancer.
Authors: Lu X, Zhang Y, Pan Y, Cao M, Zhou X, Zhang T Abstract COOH-terminus tensin-like molecule (CTEN) is a member of the tensin family, which is considered to be one of the novel proto-oncogenes involved in tumorigenesis and cancer progression. However, the mechanisms of CTEN in acquired resistance of non-small cell lung cancer (NSCLC) remain relatively unknown. The aim of the present study was to understand the roles of CTEN in acquired gefitinib resistance of NSCLC. The present study investigated the expression level of CTEN using reverse transcription-quantitative polymerase chain reaction and Western blot an...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High frequency of microsatellite instability and its substantial co-existence with KRAS and BRAF mutations in Vietnamese patients with colorectal cancer.
Authors: Nguyen HT, Le DT, Duong QH, Tatipamula VB, Van Nguyen B Abstract Tumor heterogeneity and resistance to chemotherapy have been recognized as two major obstacles in the diagnosis and treatment of colorectal cancer (CRC). Microsatellite instability (MSI) and KRAS and BRAF mutations are common diagnostic factors that have been widely used to classify CRC for therapeutics. In the present study, 151 patients with CRC were analyzed from the two most populous ethnic groups of Vietnam, Kinh and Muong, for their MSI status, frequency of KRAS and BRAF mutations, and their clinical implications. MSI-high (MSI-H) was d...
Source: Oncology Letters - December 4, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research