Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma.
Authors: Li Y, Xu A, Jia S, Huang J Abstract Hepatocellular carcinoma (HCC) is more frequently observed and aggressive in men compared with women. Increasing evidence demonstrates that the sex disparity appears to be mediated by the stimulatory effects of androgens and the protective effects of estrogen in the development and progression of HCC. In the past few decades, studies on the sex difference of HCC mainly focused on the effect of sex hormones on the transactivation of hepatitis B virus X protein and the release of inflammatory cytokines, and these studies have further intensified in recent years. Sex hormon...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A four-gene signature for prognosis in breast cancer patients with hypermethylated IL15RA.
Authors: Yang H, Zhou L, Chen J, Su J, Shen W, Liu B, Zhou J, Yu S, Qian J Abstract Previous studies have revealed that upregulation of interleukin 15 receptor α (IL15RA) contributes to improved prognosis of breast cancer. The present study aimed to elucidate the molecular mechanisms underlying the antitumor effect induced by IL15RA upregulation, and to identify a gene signature capable of predicting the survival of patients with breast cancer. Using paired gene expression and methylation data of breast cancer samples from The Cancer Genome Atlas data portal, differentially expressed genes (DEGs) were identif...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF- β1.
In conclusion, these results suggested that AA may inhibit TGF-β1-induced EMT in lung cancer through increased expression of E-cadherin, and inhibition of Snail, N-cadherin and vimentin expression. PMID: 30988806 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of key genes involved in the metastasis of clear cell renal cell carcinoma.
Authors: Wei W, Lv Y, Gan Z, Zhang Y, Han X, Xu Z Abstract Clear cell renal cell carcinoma (ccRCC) is the most common and lethal renal malignant tumor in adults. The aim of the present study was to identify the key genes involved in ccRCC metastasis. Expression profiling data for ccRCC patients with metastasis and without metastasis were obtained from The Cancer Genome Atlas database. The datasets were used to identify differentially expressed genes (DEGs) between the metastasis group and the non-metastasis group using the DESeq2 package. Function enrichment analyses of DEGs were performed. The protein-protein inte...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

AMP-activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer.
AMP-activated protein kinase α1 serves a carcinogenic role via regulation of vascular endothelial growth factor expression in patients with non-small cell lung cancer. Oncol Lett. 2019 May;17(5):4329-4334 Authors: Hui GD, Xiu WY, Yong C, Yuan CB, Jun Z, Jun GJ, Jun YJ, Xiang XX, Wei HS, Feng ML Abstract AMP-activated protein kinase α1 (AMPK α1) is involved in the tumorigenesis of various cancer types. However, the role of AMPK α1 in non-small cell lung cancer (NSCLC) remains unclear. In the present study, 99 NSCLC tumor tissues and paired normal tissues were obtained. The expres...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Demethylation of the HACE1 gene promoter inhibits the proliferation of human liver cancer cells.
In conclusion, activation of HACE1 expression by promoter demethylation may provide a suitable approach for anticancer therapy. PMID: 30988809 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical significance of BRCA1 and BRCA2 mRNA and protein expression in patients with sporadic gastric cancer.
Authors: Kim HS, Hwang IG, Min HY, Bang YJ, Kim WH Abstract The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expression and BRCA1/BRCA2 mRNA expression were evaluated using immunohistochemistry (IHC) and in-situ hybridization (ISH) on tissue GC microarray tissues, in addition to reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The re...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

RANBP9 suppresses tumor proliferation in colorectal cancer.
In conclusion, RANBP9 served an inhibitory role in CRC in vitro and in vivo. Therefore, RANBP9 may be considered a potential target for treatment of CRC. PMID: 30988811 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Efficacy and association analysis of high-dose methotrexate in the treatment of children with acute lymphoblastic leukemia.
Authors: Gong F, Meng Q, Liu C, Zhao Y Abstract Effect of high-dose methotrexate (MTX) on children with acute lymphoblastic leukemia (ALL) with different subtypes and disease courses was investigated. A retrospective analysis of 207 children with ALL who were admitted to the People's Hospital of Pingyi County from March 2014 to June 2017 was carried out. According to the subtype of the disease, the children were divided into two groups. B-lineage group: ALL occurred in B-lineage lymphocytes (n=128); T-lineage group: ALL occurred in T-lineage lymphocytes (n=79). According to the disease course, the children were div...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer and their effects on the biological characteristics of bladder cancer cells.
Authors: Xiang M, Yuan W, Zhang W, Huang J Abstract Changes in the expression of miR-490-5p, miR-148a-3p and miR-608 in bladder cancer tissues were studied. A total of 30 patients with bladder cancer who had surgical resection in the Hunan Provincial People's Hospital (Changsha, China) from April 2015 to August 2016 were selected. RT-qPCR was used to detect the expression levels of miR-490-5p, miR-148a-3p and miR-608. The expression vectors of miR-490-5p, miR-148a-3p and miR-608 were respectively transfected and divided into three groups: blank cell group, gene transfection group (groups A-C) and negative transfect...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cyclin A is a reliable proliferation marker in endometrial cancer cell lines.
Authors: Horie K, Yamamoto H, Karube K, Takebayashi K, Yoshino H, Yoshioka H, Watanabe J Abstract Cyclin A, a cell cycle regulatory protein, promotes cell proliferation and has been observed to be highly expressed in cancer and to promote tumor growth; however, its value as a marker for endometrial carcinoma has not yet been established. Accordingly, the aim of the present study was to clarify whether cyclin A can be used as a cell proliferation marker using the endometrial carcinoma cell lines Ishikawa and HEC-50B, derived from patients with low-grade and high-grade cancer, respectively. The expression of cyclin A...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Exosomes from LNCaP cells promote osteoblast activity through miR-375 transfer.
In conclusion, the present study may lead to further investigation of the function role of exosomal miR-375 in the activation and differentiation of osteoblasts in PCa. PMID: 30988815 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Five-long non-coding RNA risk score system for the effective prediction of gastric cancer patient survival.
In conclusion, a risk score system based on the green module may be applied to predict the survival of patients with GC. Furthermore, ITPK1-AS1, KCNQ1DN, LINC00167, LINC00173 and LINC00307 may serve as biomarkers for GC pathogenesis. PMID: 30988816 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Metadherin overexpression in perihilar cholangiocarcinoma is associated with lymph node metastasis and poor prognosis.
Authors: Zhu YZ, Zhou K, Ruan LL, Sun F, Wang G, Li WF Abstract Metadherin (MTDH) is a protein that is also named astrocyte elevated gene-1, and is highly expressed in a number of different tumor tissues. Although the expression of MTDH is associated with tumor invasion and recurrence, the expression of this protein in perihilar cholangiocarcinoma (PCCA) and its clinical use have not yet been investigated. In the present study, the expression of MTDH in patients with PCCA was investigated in order to determine its clinicopathological use. An immunohistochemical method was used to detect MTDH expression and the epit...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The potential role of miR-126, miR-21 and miR-10b as prognostic biomarkers in renal cell carcinoma.
Authors: Carlsson J, Christiansen J, Davidsson S, Giunchi F, Fiorentino M, Sundqvist P Abstract Renal cell carcinoma (RCC) is the most commonly diagnosed renal tumor, consisting of ~3% of all malignancies worldwide. The prognosis of RCC can vary widely, and detecting patients at risk of recurrence at an early stage of disease may improve patient outcome. The factors presently used in a clinical setting cannot reliably predict the natural history of the disease. Therefore, there is a requirement to identify novel biomarkers that can aid in predicting patient outcome. Previous studies have indicated that microRNAs (m...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Interleukin-8 promotes prostate cancer bone metastasis through upregulation of bone sialoprotein.
Authors: Liu B, Xu M, Guo Z, Liu J, Chu X, Jiang H Abstract The aim of the present study was to investigate whether interleukin-8 (IL-8) enhances the ability of prostate cancer bone metastasis by influencing the coding level of bone sialoprotein (BSP). Cultured prostate cancer cell lines LNCaP (androgen dependent) and DU145 (androgen independent) were divided into three groups: IL-8 treatment group; IL-8 receptor inhibitor (SB225002) treatment group; and control group. Western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were used to detect BSP protein and mRNA expression leve...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of CLDN6 in tissues of gastric cancer patients: Association with clinical pathology and prognosis.
Authors: Gao F, Li M, Xiang R, Zhou X, Zhu L, Zhai Y Abstract Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013. Cancer and normal adjacent tissues were obtained from the patients to detect the expression level of CLDN6 using reverse transcription-quantitative PCR (RT-qPCR). The association between the expression level of CLDN6 and the clinical and p...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The stem cell-specific intermediate filament nestin missense variation p.A1199P is associated with pancreatic cancer.
In conclusion, the amino acid 1,199 of nestin is localized in the tail structure of the filament and polymerizes with other intermediate filament proteins. The present results suggest that missense variations of nestin affect pancreatic carcinogenesis in Japanese patients. PMID: 30988821 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

IL-32 expression indicates unfavorable prognosis in patients with colon cancer.
Authors: Zhai JM, An YH, Wang W, Fan YG, Yao GL Abstract Recently, interleukin (IL)-32 has been demonstrated to represent a novel biomarker for evaluating the prognosis of patients with gastric and lung cancer; however, its clinical significance in colon cancer remains unknown. In the present study, the IL-32 expression in 60 patients with colon cancer was examined with an immunohistochemistry assay. IL-32 expression was determined in 37 (61.67%) patients with colon cancer. Additionally, IL-32 was associated with tumor size and Dukes' stage. By using the Kaplan-Meier method, patients with positive IL-32 expression ...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Comparison of diagnostic methods for the detection of a BRAF mutation in papillary thyroid cancer.
Authors: Zhao J, Liu P, Yu Y, Zhi J, Zheng X, Yu J, Gao M Abstract The most common genetic alteration identified in papillary thyroid cancer (PTC) encodes a valine to glutamic acid change at position 600 (V600E) in the BRAF proto-oncoprotein. The most accurate and reliable method for detecting this BRAF mutation has not yet been determined. In the present study, the sensitivity, specificity and feasibility of diagnostic methods for BRAF mutations were assessed. BRAF mutational analysis was performed by Sanger DNA sequencing, using the Cobas® 4800 BRAF V600 test and by immunohistochemistry (IHC). A total of 185 ...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of key pathways and genes in nasopharyngeal carcinoma using bioinformatics analysis.
In conclusion, by performing a comprehensive bioinformatics analysis of DEGs, putative targets that could be used to elucidate the molecular mechanisms underlying NPC were identified. PMID: 30988824 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Randomized controlled trial of lobaplatin plus etoposide vs. cisplatin plus etoposide as first-line therapy in patients with extensive-stage small cell lung cancer.
Authors: Cheng Y, Fan Y, Liu X, Liu Y, Liu J, Wang D, Yu Y, Qin S, Liu W, Huang C, Zhang H, Liang J, Shi J, Sheng L, Yu H Abstract The majority of previous studies of lobaplatin in small cell lung cancer (SCLC) are small phase I-II studies. The present study aimed to verify the non-inferiority (in terms of efficacy) of lobaplatin plus etoposide (EL) vs. cisplatin plus etoposide (EP) in patients with previously untreated extensive-stage SCLC (ES-SCLC). This phase III non-inferiority randomized clinical trial enrolled patients at 17 sites between September 2010 and May 2013. Patients were randomized to EL (30 mg/m2 l...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.
Authors: Zhang M, Deng W, Gong H, Li C, Wang Y, Liu X, Tao L, Zhou L Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 an...
Source: Oncology Letters - April 18, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The 2nd Conference of the Romanian Society of Immuno-Dermatology, Bucharest, September 27-29, 2018.
Authors: Neagu M, Boda D PMID: 30944597 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma.
Authors: Cioplea M, Caruntu C, Zurac S, Bastian A, Sticlaru L, Cioroianu A, Boda D, Jugulete G, Nichita L, Popp C Abstract Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. We performed a ret...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches.
In conclusion, anti-angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high-throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer-type specific individual drug targets. PMID: 30944599 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Inflammation: A key process in skin tumorigenesis.
Authors: Neagu M, Constantin C, Caruntu C, Dumitru C, Surcel M, Zurac S Abstract The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microenvironment that can lead to pro-tumorigenic processes. Regardless of the origin of the environmental factors, the maintenance of an inflammatory microenvironment is a clear condition that favors tumorigenesis. Inflammation...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Photodynamic therapy: A hot topic in dermato-oncology.
Authors: Tampa M, Sarbu MI, Matei C, Mitran CI, Mitran MI, Caruntu C, Constantin C, Neagu M, Georgescu SR Abstract Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Data available so far indicate that PDT is a promising treatment method which can be successfully employed in several medical fields includ...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Non-invasive imaging techniques for the in vivo diagnosis of Bowen's disease: Three case reports.
Authors: Ianoși SL, Batani A, Ilie MA, Tampa M, Georgescu SR, Zurac S, Boda D, Ianosi NG, Neagoe D, Calina D, Tutunaru C, Constantin C Abstract Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. There are ...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Current and future applications of confocal laser scanning microscopy imaging in skin oncology.
In this study, we present the CLSM characteristic features of the most common melanocytic and non-melanocytic skin tumors, as well as future possible CLSM applications in the study of experimental skin tumorigenesis on animal models. PMID: 30944603 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Vascular patterns in basal cell carcinoma: Dermoscopic, confocal and histopathological perspectives.
Authors: Lupu M, Caruntu C, Popa MI, Voiculescu VM, Zurac S, Boda D Abstract Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. As vascular formation and angiogenesis are indicators of tumor development and progression, the presence of blood vessels, their morphology and architecture are important markers in skin lesions, providing critical information towards pathogenesis and diagnosis...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The 1, 2, 3, 4 of carcinoid heart disease: Comprehensive cardiovascular imaging is the mainstay of complex surgical treatment.
We present a series of imaging findings in CHD patients who have successfully undergone simultaneous surgical replacement with bioprosthetic valves of 1 to 4 heart valves. The surgical decision in these patients was based on a multimodality cardiovascular approach, including transthoracic and transesophageal echocardiography and cardiac magnetic resonance. The patients had uncomplicated postoperative courses, significant symptomatic relief from heart failure symptoms, and there was no cardiovascular mortality. Early recognition of CHD with a multimodality approach may improve outcome, even in complex cases. Bioprosthetic v...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Acanthosis nigricans: To be or not to be afraid.
Authors: Popa ML, Popa AC, Tanase C, Gheorghisan-Galateanu AA Abstract Acanthosis nigricans (AN), a skin disorder with high prevalence, represents a dermatological condition with esthetic implications, but otherwise mild symptoms. For any clinician, it is in fact the tip of the iceberg, leading him/her to investigate what lies beneath the surface, since AN points to a systemic problem or disease: metabolic disorder (most frequently), endocrine syndrome, medication side effects, malignancy, and genetic factors. Sometimes, it is the first observed sign of a malignancy or of diabetes mellitus, especially in patients w...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Risk factors for melanoma and skin health behaviour: An analysis on Romanian melanoma patients.
Authors: Fechete O, Ungureanu L, Șenilă S, Vornicescu D, Dănescu S, Vasilovici A, Candrea E, Vesa ȘC, Cosgarea R Abstract In contrast to Western Europe, in Central and Eastern Europe reports show higher rates of advanced melanoma and lower survival. Our aim was to document and compare melanoma risk factors and skin health behaviour in patients diagnosed with melanoma and people not affected by this disease in a large medical university centre from Romania (Cluj-Napoca). Two hundred and forty-seven melanoma patients followed-up in the Department of Dermatology at the Cluj-Napoca Emergency County Hospital and 956...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A 10-year retrospective study of melanoma stage at diagnosis in the academic emergency hospital of Sibiu county.
In conclusion, as the incidence of melanoma increases in Romania, further efforts are needed to improve the early detection of melanoma. There are hopes that with the correct and early diagnosis of melanoma, the mortality rate of this neoplasm will decrease in the future. PMID: 30944608 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Comparative analysis of CEACAM1 expression in thin melanomas with and without regression.
We present a retrospective study including 53 consecutive cases of thin melanoma, 21 with regression and 32 without regression. Comparative analysis of CEACAM1 expression in regressed and non-regressed areas from melanomas with regression and in non-regressed melanomas was performed. We used three different clones of CEACAM1: AA 1-428, extracellular domain, rabbit; AA 1-428, mouse, clone 8B6E2F4; and AA 1-468, full length, mouse, clone 2F6. All three clones had similar reactivity. We identified membrane positivity of tumor cells in non-regressed melanomas and in non-regressed areas in melanomas with regression. Remaining t...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Tumor infiltrating lymphocytes: The regulator of melanoma evolution.
Authors: Antohe M, Nedelcu RI, Nichita L, Popp CG, Cioplea M, Brinzea A, Hodorogea A, Calinescu A, Balaban M, Ion DA, Diaconu C, Bleotu C, Pirici D, Zurac SA, Turcu G Abstract Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologic response. Melanoma has been historically considered an immunogenic malignancy. It often contains great amount of immune cells...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Vitamin D receptor polymorphisms and melanoma.
Authors: Vasilovici AF, Grigore LE, Ungureanu L, Fechete O, Candrea E, Trifa AP, Vișan S, Șenilă S, Cosgarea R Abstract Melanoma represents the most aggressive skin cancer, with an unpredictable and often treatment resistant behavior. The etiology of melanoma is multifactorial and includes both environmental and genetic factors. Recent evidence indicates that vitamin D has a role in the development and progression of melanoma. The biologically active form of vitamin D/1,25-dihydroxyvitamin D3 acts by binding to a intranuclear receptor; vitamin D receptor (VDR). Single nucleotide polymorphisms (SNPs) in the vitam...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Molecular and cellular stratagem of brain metastases associated with melanoma.
Authors: Buga AM, Docea AO, Albu C, Malin RD, Branisteanu DE, Ianosi G, Ianosi SL, Iordache A, Calina D Abstract Tumors of the central nervous system are the most prevalent complications of melanoma, especially in the late stage of disease. Melanoma, lung and breast cancer are the leading cause of secondary tumors in the brain, the majority of them having a poor outcome. Brain dissemination is developed in half of stage IV melanomas and these cases can increase up to 75%, having a major impact on the quality of life. This review will focus on recent findings that provide new ways to potentially prevent brain metast...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Complete regression of primary melanoma associated with nevi involution under BRAF inhibitors: A case report and review of the literature.
We present the case of a 58-year-old man with a completely regressed metastatic melanoma who developed a second melanoma with concomitant involution of papillomatous nevi under BRAF inhibitors treatment. In reviewed literature we have found 53 cases of completely regressed primary melanomas, neither of them reporting nevi involution. Complete regression of primary tumor can occur as an immune response to tumor progression. Nevi can involute under BRAF inhibitor therapy, but development of new malignant lesions under BRAF inhibitors is linked to BRAF wild-type. Documentation of primary tumor and dynamic changes in nevi high...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Synthesis and physiological implications of melanic pigments.
Authors: Maranduca MA, Branisteanu D, Serban DN, Branisteanu DC, Stoleriu G, Manolache N, Serban IL Abstract The process of melanin synthesis and distribution is called melanogenesis, a process that is based on melanocytes present among the basal cells of the epidermis. Pigments formed in melanocyte melanosomes are then stored in the basal layer of epidermal cells, as well as in dermal macrophages, which become melanophores. From the embryological point of view, melanocytes derive from the melanoblasts of the neural crest, from where they migrate during the first months of life into the skin, eye, cochlea, bone, pe...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Natural killer cell monitoring in cutaneous melanoma - new dynamic biomarker.
In this study, we investigated T-CD4+ and T-CD8+ lymphocytes, B lymphocytes and NK cells in peripheral blood and spleen cells suspension from melanoma-bearing mice compared to healthy controls in order to assess the potential for tumor growth-promoting immunosuppression. Our results indicate that in a melanoma-bearing mouse model the percentage of NK cells in spleen is reduced and that their phenotype is different compared to control mouse NK cells. PMID: 30944615 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Crucial role of the pentose phosphate pathway in malignant tumors.
Authors: Jin L, Zhou Y Abstract Interest in cancer metabolism has increased in recent years. The pentose phosphate pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its oxidative branch and leads to the production of a reduced form of nicotinamide adenine dinucleotide phosphate and nucleic acid. The PPP serves a vital role in regulating cancer cell growth and involves many enzymes. The aim of the present review was to describe the recent discoveries associated with the deregulatory mechanisms of the PPP and glycolysis in malignant tumors, particularly in hepatocellular carcinoma, brea...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of tumor size on prognosis in differentiated thyroid carcinoma smaller than 2 cm.
Authors: Zhang TT, Li CF, Wen SS, Huang DZ, Sun GH, Zhu YX, Wang Y, Ji QH, Qu N, Shi RL Abstract Benefits of subdividing small-differentiated thyroid carcinoma (sDTC) by tumor size are controversial. We conducted a meta-analysis to investigate whether tumor size is associated with prognosis of sDTC. PubMed and Web of Science databases were searched from their inception to September 2018. The identified studies according to the inclusion/exclusion criteria were analyzed using fixed/random-effects models. Data were calculated and results of the meta-analysis were expressed as odd ratio (OR). sDTC was classified as S1...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Pharmacokinetic analysis for the differentiation of pituitary microadenoma subtypes through dynamic contrast-enhanced magnetic resonance imaging.
Authors: Zhai J, Zheng W, Zhang Q, Wu J, Zhang X Abstract The value of pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in distinguishing pituitary microadenoma subtypes was investigated in the present study. Pathology and follow-up outcomes were applied as the gold standard for differentiating between 76 patients with pituitary microadenomas (38 prolactin-producing tumors, 17 adrenocorticotropic hormone adenomas and 21 growth hormone-producing tumors) and 20 patients with normal pituitary glands. DCE-MRI was conducted to obtain the following quantitative permea...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Sodium orthovanadate inhibits growth and triggers apoptosis of human anaplastic thyroid carcinoma cells in vitro and in vivo.
In conclusion, the present study demonstrated that SOV inhibited human ATC by regulating proliferation, cell cycle progression and apoptosis, thus suggesting that SOV may be considered a novel option for the treatment of ATC. PMID: 30944619 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of ISOC1 suppresses cell proliferation in pancreatic cancer in vitro.
In conclusion, ISOC1 exerts a role in pancreatic cancer cell growth and apoptosis, and may have a role in pancreatic cancer tumorigenesis. PMID: 30944620 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Diagnostic efficacy of PET/CT in bone tumors.
Authors: Han S, Li Y, Li Y, Zhao M Abstract Clinical value of PET/CT (positron emission tomography/computed tomography) in the diagnosis of malignant bone tumors (BT) was investigated. Fifty-four patients with BT were first diagnosed by ordinary CT and then by PET/CT. The diagnostic efficacy outcomes and diagnosis of malignant BT by clinical stage of the two methods for BT were observed and recorded, and the diagnostic value of PET/CT in the diagnosis of BT was evaluated. There were 14 cases of benign BT patients, 15 cases of stage I, 10 cases of stage II and 15 cases of stage III in malignant BT patients. The diag...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Combination of metformin and paclitaxel suppresses proliferation and induces apoptosis of human prostate cancer cells via oxidative stress and targeting the mitochondria-dependent pathway.
Authors: Zhao Y, Zeng X, Tang H, Ye D, Liu J Abstract Previous studies have reported that metformin (MET) has anticancer activity. In combination with chemotherapeutic drugs, MET reduces the dosage of chemotherapeutic drugs required and enhances anticancer efficacy. In the present study, the combination of MET and paclitaxel (PTX) in three human prostate cancer (PCa) cell lines (22RV1, PC-3 and LNCaP) was evaluated to investigate the effects on proliferation and apoptosis of PCa cells. The present study explored whether their effects were associated with reactive oxygen species (ROS). An MTT assay and microscopy we...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Diagnostic value analysis of combined detection of Trx, CYFRA21-1 and SCCA in lung cancer.
Authors: Qu T, Zhang J, Xu N, Liu B, Li M, Liu A, Li A, Tang H Abstract The expression levels of thioredoxin (Trx), cytokeratin fragment 21-1 (CYFRA21-1) and serum squamous cell carcinoma antigen (SCCA) in patients with lung cancer and the diagnostic value of combined detection were investigated. Sixty-five patients with lung cancer in Weihai Municipal Hospital from January 2014 to June 2017 were retrospectively selected as the observation group, while 60 healthy subjects receiving physical examination were selected as the control group. The expression levels of serum Trx, CYFRA21-1 and SCCA were detected. The sens...
Source: Oncology Letters - April 5, 2019 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research