Chromosome instability in neuroblastoma.
Authors: Fusco P, Esposito MR, Tonini GP Abstract Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Novel insight into the function of tankyrase.
Authors: Kim MK Abstract Tankyrases are multifunctional poly(ADP-ribose) polymerases that regulate a variety of cellular processes, including Wnt signaling, telomere maintenance and mitosis regulation. Tankyrases interact with target proteins and regulate their interactions and stability through poly(ADP-ribosyl) ation. In addition to their roles in telomere maintenance and regulation of mitosis, tankyrase proteins regulate tumor suppressors, including AXIN, phosphatase and tensin homolog and angiomotin. Therefore, tankyrases may be effective targets for cancer treatment. Tankyrase inhibitors could affect a variety...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-639 is associated with advanced cancer stages and promotes proliferation and migration of nasopharyngeal carcinoma.
Authors: Wang YH, Yin YW, Zhou H, Cao YD Abstract Early detection of nasopharyngeal carcinoma (NPC) is of vital importance for improving prognosis and survival rates. MicroRNA (miRNA) are a class of short and non-coding RNA molecules that are capable of inhibiting the translation of mRNA of target genes. Previous studies have revealed that miRNA are involved in tumorigenesis and cancer development. The RNase-resistance of circulating miRNA have made them valuable non-invasive biomarkers, and has therefore drawn particular attention to their therapeutic potential. The aim of the present study was to investigate the ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes.
Authors: Hou Z, Tao X, Zhang J, Wu Z, Liu B Abstract Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. A retrospective analysis was conducted on the clinical, imaging, pathological and immunohistochemical characteristics of 8 patients with TE in the filum terminale and t...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Potential clinical value and putative biological function of miR-122-5p in hepatocellular carcinoma: A comprehensive study using microarray and RNA sequencing data.
Authors: Wen DY, Huang JC, Wang JY, Pan WY, Zeng JH, Pang YY, Yang H Abstract In order to determine the diagnostic efficacy of microRNA (miR)-122-5p and to identify the potential molecular signaling pathways underlying the function of miR-122-5p in hepatocellular carcinoma (HCC), the expression profiles of data collected from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and literature databases were analyzed, along with any associations between clinicopathological characteristics and the diagnostic value of miR-122-5p in HCC. The intersection of 12 online prediction databases and differentially exp...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells through the protein kinase B/glycogen synthase kinase 3 β/β-catenin signaling pathway.
Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells through the protein kinase B/glycogen synthase kinase 3β/β-catenin signaling pathway. Oncol Lett. 2018 Dec;16(6):6930-6939 Authors: Zhou Q, Zhang Z, Song L, Huang C, Cheng Q, Bi S, Hu X, Yu R Abstract Cordyceps militaris is widely used as a traditional Chinese medicine health supplement, and is also used in the development of anticancer agents. In our previous studies, it was revealed that C. militaris fraction (CMF) possessed an antitumor effect against K562 cells in vitro, induced apoptosis and caused cel...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-128 targeting RPN2 inhibits cell proliferation and migration through the Akt-p53-cyclin pathway in colorectal cancer cells.
In conclusion, the results suggested that miR-128 was a specific negative regulator of RPN2, which regulated colorectal cancer cell proliferation and migration by affecting the Akt-p53-cyclin pathway. These data may provide novel evidence for the therapeutic potential of miR-128-based treatments for colorectal cancer. PMID: 30546426 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Authors: Romero-Lorca A, Gaibar M, Armesilla AL, Fernandez-Santander A, Novillo A Abstract The present study examined the mRNA expression levels of different isoforms of the plasma membrane calcium ATPase 2 (PMCA2) gene generated by alternative splicing at the first intracellular loop (site A) and C-terminal region (site C) in 85 human breast cancer tumor and 69 adjacent non-tumor tissues. Associations were identified between the expression of PMCA2 splice isoforms and the following clinical variables: Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status, tum...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-34a inhibits metastasis in liver cancer cells.
Authors: Wei W, Tang H, Tang L Abstract MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR-34a is able to regulate cell cycle and tumorigenicity. The level of miR-34a expression is usually low in tumors, and previous studies have indicated miR-34a to be an important tumor suppressor. In order to elucidate the association between miR-34a and metastasis, stable cell lines were established and transfected with miR-34a. Cell invasion assay was subsequently performed. The present study demonstrated that cell invasion was inhibited...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Relationship between the genetic expression of WTAP and bladder cancer and patient prognosis.
Authors: Chen L, Wang X Abstract The relationship between the gene expression of Wilms tumor 1-associated protein (WTAP) and bladder cancer was investigated to study the effect of its expression on patient prognosis. Sixty-two fresh specimens of bladder transitional cell cancer tissues were collected as the bladder cancer group, while 20 normal bladder mucosa specimens comprised the control group. Hematoxylin and eosin staining was conducted to detect the pathological differences between the groups and the immunohistochemistry was used to test the expression levels of WTAP in the tissues. Reverse transcription-poly...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Correlation of xeroderma pigmentosum complementation group F expression with gastric cancer and prognosis.
Authors: Li P, Ma Y Abstract Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissues (observation group) and normal gastric mucosa adjacent to tumor (control group) via immunohistochemistry. Correlation between XPF expression and clinicopathological indicators of gastric cancer was verified via single-factor Chi-square test. Cox's proportional hazard regr...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The development of simultaneous measurement of viral load and physical status for human papillomavirus 16 and 18 co-infection using multiplex quantitative polymerase chain reaction.
Authors: Prasongdee P, Tippayawat P, Limpaiboon T, Leelayuwat C, Wongwattanakul M, Jearanaikoon P Abstract Persistent infection with human papillomavirus (HPV) type 16 and 18 is known to be a major risk factor for cervical cancer. Increased prevalence of co-infection with these high-risk types has been observed in pre-cancerous and cancerous tissues. The determination of physical status and copy numbers of viruses is therefore useful in clinical settings. A simple multiplex quantitative polymerase chain reaction (qPCR) for HPV16/HPV18 co-infection in one tube reaction was established in the present study using TaqM...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical diagnosis of adult patients with acute megakaryocytic leukemia.
In conclusion, the diagnosis of AMKL requires a combination of the results of bone marrow smears and bone marrow biopsy, immunophenotype or immunohistochemistry. We recommend that routine immunophenotypic analysis should include the CD41 and CD61 markers for diagnosing acute leukemia when bone marrow morphology does not indicate the diagnosis. PMID: 30546432 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.
This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. In addition, a preliminary...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Co-expression network analysis of gene expression profiles of HER2+ breast cancer-associated brain metastasis.
Authors: Yuan F, Wang W, Cheng H Abstract Brain metastasis occurs in ~30% of patients with breast cancer, and patients with human epidermal growth factor receptor 2 (HER2)+ breast cancer have a particularly high frequency of brain metastasis. Weighted gene co-expression network analysis was conducted to identify the hub differentially expressed genes from patients with HER2+ breast cancer between brain metastases and primary tumors. The potential candidate genes were investigated in another set of patient samples to confirm their relevance. The results indicated that a number of pathways altered significantly when ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF- κB-dependent epithelial-to-mesenchymal transition.
FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF-κB-dependent epithelial-to-mesenchymal transition. Oncol Lett. 2018 Dec;16(6):7020-7028 Authors: Gao Y, Elamin E, Zhou R, Yan H, Liu S, Hu S, Dong J, Wei M, Sun L, Zhao Y Abstract FK506-binding protein 51 (FKBP51) is a member of the immunophilin family, with relevant roles in multiple signaling pathways, tumorigenesis and chemoresistance. However, the function of FKBP51 in papillary thyroid carcinoma (PTC) remains largely unknown. In the present study, increased FKBP51 expression was detected in PTC tissues as compar...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Chitosan-based nanoparticles with damnacanthal suppress CRM1 expression.
Authors: Chaichanasak N, Rojanapanthu P, Yoon Y, Gritsanapan W, Chirachanchai S, Sathirakul K, Nualsanit T, Seong JK, Baek SJ Abstract Cancer is one of the leading causes of mortality worldwide. Phytochemicals may be promising anticancer agents given their various chemical structures and diverse biological activities. Damnacanthal (DAM) is a major bioactive component of Noni, which has been investigated previously as a cancer-preventive or chemotherapeutic agent. DAM has also been reported to exhibit anti-proliferative activity in several cancer types. In the present study, it was identified that DAM downregulates ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Microbiota dysbiosis is associated with HPV-induced cervical carcinogenesis.
Authors: Kwasniewski W, Wolun-Cholewa M, Kotarski J, Warchol W, Kuzma D, Kwasniewska A, Gozdzicka-Jozefiak A Abstract Cervical microbial communities serve a crucial role in the persistence and development of oncogenic human papilloma virus (HPV) infections. In the present study, the authors hypothesised that disturbed heterogeneity of microbial flora was associated with HPV-induced carcinogenesis. Swabs of the cervical microbiota were collected from 250 women and the 16S ribosomal DNA was sequenced using a high throughput assay. The swabs of cervical microbiota were grouped according to the community state types (C...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prognostic implications of decreased microRNA-101-3p expression in patients with non-small cell lung cancer.
Authors: Lu HM, Yi WW, Ma YS, Wu W, Yu F, Fan HW, Lv ZW, Yang HQ, Chang ZY, Zhang C, Xie WT, Jiang JJ, Song YC, Chai L, Jia CY, Lu GX, Zhong XJ, Hou LK, Wu CY, Shi MX, Liu JB, Fu D Abstract To investigate the expression level of microRNA-101-3p (miR-101-3p) and its possible association with progression, prognosis and chemotherapy in patients with non-small cell lung cancer (NSCLC), the Gene Expression Omnibus (GEO) database was used. Quantitative polymerase chain reaction was used to verify the expression in 327 NSCLC and 42 adjacent normal lung tissues, of which 42 viable tissues were paired with nearby normal lun...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.
In conclusion, the results of the present study indicated that surgically resected MIA cases harboring different EGFR gene statuses exhibit distinct clinicopathological features. Significant differences in pathological features associated with the tumor microenvironment were identified in MIA with 19Del or L858R mutations. Therefore, the present study proposed that MIA should be classified into molecular subgroups based on EGFR mutation subtypes. The molecular sub-classification should be taken into account for prognostic evaluation and clinical management of MIA. PMID: 30546439 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effect of PM2.5 on invasion and proliferation of HeLa cells and the expression of inflammatory cytokines IL-1 and IL-6.
Authors: Huang K, Li W, Chen Y, Zhu J Abstract Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferation was detected by MTT assay. Transwell assay was performed to detect the invasion of HeLa cells. Enzyme-linked immunosorbent assay (ELISA), RT-qPCR and western blotting were used to detect the expression levels of inflammatory cytokines IL-1 an...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical application of plasma mitochondrial DNA content in patients with lung cancer.
Authors: Chen J, Zhang L, Yu X, Zhou H, Luo Y, Wang W, Wang L Abstract Alterations of mitochondrial DNA (mtDNA) have been identified in several types of solid tumor. However, to the best of our knowledge, the clinical significance of plasma mtDNA content in lung cancer remains unknown. Thus, the current study explored the diagnostic and prognostic value of plasma mtDNA quantification in patients with lung cancer. Plasma mtDNA copy numbers of patients with lung cancer (n=128) and healthy individuals (n=107) were quantified by quantitative polymerase chain reaction. Plasma mtDNA copy numbers in patients and healthy c...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/ β-catenin signaling pathway in hepatocellular carcinoma.
Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/β-catenin signaling pathway in hepatocellular carcinoma. Oncol Lett. 2018 Dec;16(6):7082-7090 Authors: Yin Z, Xu W, Xu H, Zheng J, Gu Y Abstract Histone deacetylase 6 (HDAC6), a specific histone deacetylase family member, serves an essential role in the regulation of gene expression, cell cycle progression, autophagy and apoptosis. There are numerous reports on the function of HDAC6 in cancer. However, the specific function of HDAC6 in hepatocellular carcinoma (HCC) has yet to be revealed....
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

ALK expression favorably impacts the prognosis of NRAS-mutated metastatic melanomas.
In conclusion, we suggest that ALK positive/NRAS mutated metastases represent a specific subset of metastatic melanomas, associated with a better prognosis. Validation of these observations in larger cohorts could contribute to understand the molecular events cooperating to melanoma progression, in addition to open new perspectives in the clinical and therapeutic management of this subgroup of patients. PMID: 30546443 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Correlation between Bax gene polymorphisms and esophagus cancer.
Authors: Sun L, Wei L, Wei L, Li D Abstract The present study investigated the association between the G(-248)A single nucleotide polymorphism (SNP) in the promoter region of B-cell lymphoma 2 (Bcl-2) associated X protein (Bax), which is a pro-apoptosis gene and the clinicopathological parameters and prognosis of patients with esophagus cancer. Three genotypes (AA, AG and GG) of Bax G(-248)A SNP were detected in 75 patients with esophageal squamous cell carcinoma (ESCC) via polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). The expression of Bax in tumor tissues from 75 patients with ESCC...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Racial disparities in the survival time of patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma between Chinese patients and patients of other racial groups: A population-based study from 2004 to 2013.
In conclusion, race/ethnicity was a significant independent prognostic factor in the HCC cohort, whereas it was not significant in the ICC cohort. The synergistic effect of contributing factors, including demographic, socioeconomic, biological and treatment differences, caused the racial disparity observed in primary liver cancer survival time. PMID: 30546445 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

CT scan and magnetic resonance diffusion-weighted imaging in the diagnosis and treatment of esophageal cancer.
Authors: Guo L, Zhang L, Zhao J Abstract Value of computed tomography (CT) scan and diffusion-weighted imaging (DWI) in the diagnosis and treatment of esophageal cancer was investigated. Seventy-eight patients with esophageal cancer treated in Jinan Central Hospital (Jinan, China) from January 2013 to June 2014 were selected. All patients underwent CT scan and DWI examination, and their clinical history data were analyzed. DWI was conducted. The short-term curative effect and the 3-year survival rate of patients in the high apparent diffusion coefficient (ADC) value group and the low ADC value group were compared; ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma.
Authors: Han C, Gao L, Bai H, Dou X Abstract Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. However, to the best of our knowledge, the diagnostic value of AKR1B10 in early stage HCC is poorly understood. In the current study, the diagnostic performance of serum AKR1B10 in hepatitis B virus/hepatitis C virus (HBV/HCV)-related liver d...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Oxidative stress induced by carboplatin promotes apoptosis and inhibits migration of HN-3 cells.
Authors: He PJ, Ge RF, Mao WJ, Chung PS, Ahn JC, Wu HT Abstract Laryngeal squamous cell carcinoma (LSCC) is currently a serious public health problem in China; thus, it is urgent to identify effective treatment strategies for this disease. Previous studies demonstrated that reactive oxygen species (ROS) serve important roles in the apoptosis of LSCC cells. It has also been indicated that carboplatin (CBDCA), a second-generation platinum compound with broad antineoplastic properties, is able to induce oxidative stress to produce ROS, which in turn promotes apoptosis. Thus, the present study investigated if CBDCA is ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High expression of class III β-tubulin in upper gastrointestinal cancer types.
In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types. PMID: 30546449 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of mdig on proliferation and apoptosis of lung cancer cells.
Authors: Xu X, Cao L, Zhang Y, Lian H, Sun Z, Cui Y Abstract Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference (RNAi) technique. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were used to detect the effects of mdig small interfering RNA (siRNA) on messenger RNA (mRNA) and the protein expression of mdi...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of miR-204 in pediatric retinoblastoma and its effects on proliferation and apoptosis of cancer cells.
Authors: Ding J, Lu X Abstract Expression, clinical significance and molecular mechanism of miR-204 in human retinoblastoma (RB) and para-carcinoma tissues were investigated. A total of 110 cases of RB tissues preserved after ophthalmectomy in the First Affiliated Hospital of Hunan Normal University (People's Hospital of Hunan Province) from April 2013 to June 2017 were collected along with 100 cases of para-carcinoma normal tissues. The expression of miR-204 in RB tissues was detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and its associations with clinicopathological features ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Association between the expression levels of IL-6 and IL-6R in the hepatocellular carcinoma microenvironment and postoperative recurrence.
Authors: Zhang M, Zhang S, Yang Z, Hu J, Hu W, Sun P, Wu L, Han B Abstract The tumor microenvironment of hepatocellular carcinoma (HCC) is a complex system, involving mutual promotion and inhibition between cells and molecules. It results in alterations to inflammatory-associated factors, including a decrease in interleukin (IL)-2 and an increase in tumor necrosis factor, together with a characteristic elevation of IL-6. Following the synthesis and release of IL-6, HCC is stimulated through IL-6 binding to the IL-6 receptor (IL-6R). In the present study, immunohistochemistry was performed to investigate the express...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Methylation of CADM1 and MAL together with HPV status in cytological cervical specimens serves an important role in the progression of cervical intraepithelial neoplasia.
Authors: Meršaková S, Holubeková V, Grendár M, Višňovský J, Ňachajová M, Kalman M, Kúdela E, Žúbor P, Bielik T, Lasabová Z, Danko J Abstract Cervical cancer (CC) is the second most common type of cancer affecting the female population. The development of CC takes several years, and involves a precancerous stage known as cervical intraepithelial neoplasia (CIN). A key factor in the development of disease is the human papillomavirus (HPV) infection, which initiates carcinogenesis. Furthermore, CC is also impacted by epigenetic changes such as DN...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells.
This study investigated the role of miR-214 in modulating proliferation and invasion of human colon cancer SW620 cells. Fifty-five patients with colon cancer who were treated in China-Japan Union Hospital of Jilin University from March 2014 to March 2015 were enrolled into this study. Their cancer and corresponding paracancerous tissues were collected and the expression levels of miR-214 were determined by RT-qPCR. A miR-214 expression vector was constructed. SW620 cells were transfected with the miR-214 expression vector and a blank vector. Cells transfected with the miR-214 expression vector were assigned to the miR-214 ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Shank-associated RH domain-interacting protein expression is upregulated in entodermal and mesodermal cancer or downregulated in ectodermal malignancy.
Authors: Liang Y, Chen B, Liu F, Wang J, Yang Y, Zheng Y, Tan S Abstract Shank-associated RH domain-interacting protein (SHARPIN) is a type of linear ubiquitin chain-associated protein, which serves an important role in cell proliferation, apoptosis, organ development, immune and inflammatory reaction, initiation and development of malignant tumors. To evaluate SHARPIN expression in multiple malignant tumors derived from different germ layers, 14 types of cancer and their corresponding normal tissues were examined. Immunohistochemistry was performed to semi-quantify SHARPIN expression in multiple malignant tumors, ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Correlative analysis of the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection.
This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. At the same time, 30 cases of chronic cervicitis were selected as the control group. RT-qPCR was used to detect the expression of IL-10 and Ki-67 in cervical tissue. PCR was use...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The possible different roles of denosumab in prevention and cure breast cancer bone metastases: A 'hypothesis-generator' study from clinical practice.
This study demonstrated that a pro-active attitude enables the treatment of the majority of patients with denosumab without significant class-related toxicities. The majority of SREs were from radiation therapy, so pain still remains the clinical hallmark of bone metastases, particularly for osteolytic ones. The suggestion that estrogen deprivation with AIs can favor a 'bone-related' risk conditions for developing bone metastases must be considered with caution and surely needs further validations. PMID: 30546457 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma.
Authors: Yu N, Zhang P, Wang L, He X, Yang S, Lu H Abstract Retinoblastoma-binding protein 7 (RBBP7) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in tumor progression. In the present study, the expression and roles of RBBP7 were explored in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was used to detect RBBP7 expression in ESCC tissues. The mRNA sequencing profiles from the Cancer Genome Atlas and Genotype-Tissue Expression databases were mined to analyze the mRNA expression of R...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cancers among adolescents and young adults at one institution in Japan.
Authors: Kamimura K, Matsumoto Y, Zhou Q, Moriyama M, Saijo Y Abstract Adolescents and young adults (AYAs) with cancer often live long lives following treatment and face many life events. No detailed studies of cancers in AYAs have described the epidemiology, treatment outcome, and social status in Japan. The present study defined AYAs as those aged 15-29 years old based on the US National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program. Data was collected from the hospital-based cancer registry and electronic medical charts at Niigata University Medical and Dental Hospital from 2007 to ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

RASEF expression correlates with hormone receptor status in breast cancer.
Authors: Shibata M, Kanda M, Shimizu D, Tanaka H, Umeda S, Miwa T, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Kodera Y, Kikumori T Abstract Breast cancer (BC) is the most frequently diagnosed malignant tumor in women worldwide, and the development of new molecules associated with BC is essential for the management of this disease. RAS and EF-hand domain-containing (RASEF) encodes the GTPase enzyme that belongs to the Rab family. Although the effects of this gene have been reported in several malignant tumor types, the role of RASEF in BC has not been completely elucidated...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells.
Authors: Zhang B, Shi D, Zhang X, Liang G, Liu W, Qiao S Abstract Epithelial-mesenchymal transition (EMT) is known to serve a pivotal function in hepatocellular carcinoma (HCC) metastasis. Nicotinamide phosphoribosyltransferase (NAMPT), the key enzyme in the nicotinamide-adenine dinucleotide (NAD+)-mediated pathway for the activation of silent information regulator 1 (SIRT1), serves a key function in HCC cell invasion and metastasis. Previous studies demonstrated that FK866, a targeted NAMPT inhibitor, inhibits the viability of HCC cells and induces cancer cell apoptosis; however, the effect of FK866 on the invasio...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prognostic role of miR-760 in hepatocellular carcinoma.
Authors: Sun D, Lu J, Hu C, Zhang Q, Wang X, Zhang Z, Hu S Abstract Previous studies have demonstrated that microRNA (miR)-760 serves an important role in various cancer types. However, to the best of our knowledge, its role in hepatocellular carcinoma (HCC) has not been fully elucidated. The current study investigated the prognostic role of miR-760 in HCC by using the Kaplan-Meier plotter database. The current data indicated that low expression of miR-760 was associated with higher overall survival (OS) for all patients with HCC from both the RNA-seq [hazard ratio (HR)=2.04; 95% confidence interval (CI)=1.44-2.89;...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Possible predictive role of cancer/testis antigens in breast ductal carcinoma in situ.
Authors: Roguljic A, Spagnoli G, Juretic A, Sarcevic B, Banovic M, Beketic Oreskovic L Abstract Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcin...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Focal positivity of immunohistochemical markers for pulmonary squamous cell carcinoma in primary pulmonary choriocarcinoma: A histopathological study.
Authors: Matsukuma S, Obara K, Utsumi Y, Miyai K, Takeo H, Oshika Y, Sensaki K Abstract Cytokeratin 5/6 (CK5/6), p63, and p40 are commonly used as immunohistochemical markers for squamous cell carcinoma (SqCC) of the lung. To elucidate their positivity in primary pulmonary choriocarcinoma (PPC), the present study examined 4 PPCs, including 1 surgically removed PPC and 3 postmortem PPCs. All PPCs consisted of nested cytotrophoblastic tumor cells and occasional syncytiotrophoblastic tumor cells although 1 surgically removed PPC was markedly affected by pre-operative therapy-associated necrosis and 3 postmortem PPCs c...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.
Authors: Sato Y, Kudo SE, Ichimasa K, Matsudaira S, Kouyama Y, Kato K, Baba T, Wakamura K, Hayashi T, Kudo T, Ogata N, Mori Y, Misawa M, Toyoshima N, Ishigaki T, Yagawa Y, Nakamura H, Sakurai T, Shakuo Y, Suzuki K, Kudo Y, Hamatani S, Ishida F, Miyachi H Abstract With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological feat...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Lenvatinib as a novel treatment for anaplastic thyroid cancer: A retrospective study.
Authors: Iwasaki H, Yamazaki H, Takasaki H, Suganuma N, Nakayama H, Toda S, Masudo K Abstract Anaplastic thyroid cancer (ATC) is associated with an extremely poor prognosis and is resistant to the majority of chemotherapies. In 2015, lenvatinib was approved for treating ATC in Japan. The present study aimed to evaluate the overall survival (OS) of patients with ATC treated with lenvatinib. A total of 23 patients with a definitive histological diagnosis of ATC who were treated at Kanagawa Cancer Center (Yokohama, Kanagawa. Japan) were enrolled. Surgical treatment was possible in 10 patients (including one debulking ...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.
Authors: Bandoh N, Akahane T, Goto T, Kono M, Ichikawa H, Sawada T, Yamaguchi T, Nakano H, Kawase Y, Kato Y, Kamada H, Harabuchi Y, Shimizu K, Nishihara H Abstract Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy be...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Methylation level of Rap1GAP and the clinical significance in MDS.
Authors: Ding WJ, Yang Y, Chen ZX, Wang YY, Dong WL, Cen JN, Qi XF, Jiang F, Chen SN Abstract Previous studies on the pathogenesis of myelodysplastic syndrome (MDS) have identified multiple associated gene mutations, including mutations of tetmethylcytosinedioxygenase 2, isocitrate dehydrogenase [NADP(+)] 1 cytosolic, isocitrate dehydrogenase [NADP(+)] 2 mitochondrial and additional sex combs like 1 transcriptional regulator, all of which may be considered epigenetic regulators. Furthermore, mutations of RAS type GTPase family genes have been identified in 10-15% patients with MDS. The authors' previous study on th...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer.
Authors: Yang Y, Sun Y, Wang H, Li H, Zhang M, Zhou L, Meng X, Wu Y, Liu P, Liu X, Zhang J, Tan X Abstract Pancreatic cancer is an aggressive type of cancer with a poor prognosis, short survival rate and high mortality. Therefore, understanding the molecular mechanism underlying the aggressive growth of pancreatic cancer is of importance. An increasing number of studies suggest that numerous microRNAs (miRNAs/miRs) are associated with the tumorigenesis, progression and prognosis of tumors. In a recent study by the present authors, it was revealed that the expression of miR-221 was significantly downregulated in hig...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research