Role of Gd2O3-doped carbon-11-choline-lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer.
In conclusion, GdCho-Len-PET increased the diagnostic efficacy and had a significant effect on survival for patients with lung cancer, and may therefore serve as a reliable method for human cancer diagnosis. PMID: 32002026 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer.
Authors: Chen P, Wang Y, Fang X, Wang X, Wang G Abstract Prognostic value of peritumoral fibrosis (PF) in pancreatic head cancer after resection was evaluated. A total of 143 pancreatic cancer patients who underwent tumor resection were enrolled. All patients underwent routine preoperative examination, including contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI). Patients receiving preoperative chemoradiation were excluded because it affects the proportion of fibrosis and cancer cells. Histopathological confirmation and classification of pancreatic head cancer (PHC) was made according to...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

lncRNA PVT1 accelerates progression of non-small cell lung cancer via targeting miRNA-526b/EZH2 regulatory loop.
Authors: Qiu C, Li S, Sun D, Yang S Abstract Biological function of plasmacytoma variant translocation 1 (PVT1) in influencing the progression of non-small cell lung cancer (NSCLC) through Micro ribonucleic acid (miRNA)-526b/EZH2 regulatory loop was elucidated. Relative levels of PVT1 and miRNA-526b in NSCLC tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Prognostic potential of PVT1 in NSCLC was assessed by Kaplan-Meier curves. The interaction among PVT1/miRNA-526b/EZH2 regulatory loop was confirmed by dual-luciferase reporter gene assay. Regulatory effects of PVT1/miRNA-526b/E...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells.
Authors: Qi SG, Quan LQ, Cui XY, Li HM, Zhao XD, Li RT Abstract Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E w...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cardamonin as a potential treatment for melanoma induces human melanoma cell apoptosis.
Authors: Yue Y, Liu L, Liu P, Li Y, Lu H, Li Y, Zhang G, Duan X Abstract 2',4'-dihydroxy-6'-methoxychalcone (cardamonin) is a natural compound with anti-proliferative effects on several cancer types including nasopharyngeal carcinoma. The effects of cardamonin on melanoma cells are unknown. The present study investigated the anti-proliferative effect of cardamonin on human melanoma cell lines (M14 and A375), and the underlying apoptosis inducing mechanisms. MTS assay showed that cardamonin inhibited M14 cells viability, and a reduction of the M14 cell density was also observed. Flow cytometry showed that cardamonin...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeting of TLE3 by miR-3677 in human breast cancer promotes cell proliferation, migration and invasion.
Authors: Peng LN, Deng XY, Gan XX, Zhang JH, Ren GH, Shen F, Feng JH, Cai WS, Xu B Abstract Numerous studies have indicated an important function of microRNAs (miRs) in breast cancer (BC) progression, oncogenesis and metastasis. However, the function of miR-3677, which has been revealed to be upregulated in BC [The Cancer Genome Atlas (TCGA) data], has not been investigated to date. In the present study, miR-3677 was revealed to be upregulated in BC as determined using TCGA. miR-3677 was significantly upregulated in BC tissues and cell lines compared with those noted in adjacent non-cancerous tissues and primary normal breast cells (P
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-608 promotes apoptosis via BRD4 downregulation in pancreatic ductal adenocarcinoma.
Authors: Li M, Li T, Ma W, Wang X, Zhao G Abstract The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor even among patients with the same Tumor-Node-Metastasis stage. Thus, it is necessary to identify biomarkers that can accurately predict outcomes. There is accumulating evidence suggesting that microRNA (miR) expression influences overall survival (OS) time in patients with PDAC, via the regulation of tumor suppressor genes and oncogene expression. Specifically, miR-608 expression is hypothesized to regulate PDAC progression via the downregulation of bromodomain-containing protein 4 (BRD4) express...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Survival prediction models for patients with anal carcinoma receiving definitive chemoradiation: A population-based study.
Authors: Wu Y, Han X, Li Y, Zhu K, Yu J Abstract The present study aimed to develop two nomograms in order to predict cancer-specific survival (CSS) and overall survival (OS) of patients with anal carcinoma receiving definitive chemoradiotherapy. Data from studies including patients with anal carcinoma, who were determined to be positive histologically and diagnosed between 2004 and 2010, were obtained from the Surveillance, Epidemiology, and End Results database. Significant prognostic factors for CSS and OS of patients were screened to develop nomograms through univariate and multivariate analyses. Nomograms were...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Clinical characteristics of malignant melanoma in central China and predictors of metastasis.
Authors: Shi K, Zhu X, Liu Z, Sun N, Gu L, Wei Y, Cheng X, Zhang Z, Xie B, Yang S, Li G, Liu L Abstract Cutaneous malignant melanoma (MM) is the most malignant type of all skin neoplasms. There is wide variability in the characteristics of MM between patients of different races. The aim of the present study was to investigate the clinicopathological characteristics of patients with MM in central China and to assess the value of specific hematological and biochemical indices for predicting metastasis. The data of 167 patients with MM from the First Affiliated Hospital of Zhengzhou University (Henan, China) were retr...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non-coding RNAs.
Authors: Zhang Q, Lin Z, Zhang H, Bao X, Zhang H Abstract Long non-coding RNAs (lncRNAs) are a subgroup of RNAs able to regulate gene expression at the epigenetic level, and are therefore central to the regulation of numerous biological processes and the progression of multiple cancer types. However, lncRNAs have not been identified to considerably influence overall survival (OS) outcome in numerous different types of cancer. The majority of studies investigating the association between lncRNAs and epigenetic regulation have focused on their altered expression levels in cancerous cells, and few studies have focused...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

lncRNA SNHG7 affects malignant tumor behaviors through downregulation of EZH2 in uveal melanoma cell lines.
Authors: Wu X, Yuan Y, Ma R, Xu B, Zhang R Abstract Previous studies have demonstrated that the long non-coding RNA, small nucleolar RNA host gene 7 (SNHG7) plays an important role in several types of cancer; however, its role in the development of uveal melanoma (UM) remains unclear. The present study investigated the effect of SNHG7 on the prognosis of UM, as well as on cell proliferation, cell cycle and apoptosis of UM cell lines. Furthermore, the present study aimed to determine the molecular mechanisms underlying these effects. The association between SNHG7 and prognosis of UM was analyzed using detailed SNHG7...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Intercellular adhesion molecule-1 and S-100 β in sevoflurane combined with epidural anesthesia for radical resection of lung cancer.
Intercellular adhesion molecule-1 and S-100β in sevoflurane combined with epidural anesthesia for radical resection of lung cancer. Oncol Lett. 2020 Feb;19(2):1544-1550 Authors: Zhao N, Lu C, Liu L, Sun P, Han J Abstract Significance of intercellular adhesion molecule-1 (ICAM-1) and S-100β protein (S-100β) were investigated in sevoflurane combined with epidural anesthesia for radical resection of lung cancer. In total, 172 patients who underwent radical resection of lung cancer from May 2014 to January 2016 and 160 blood samples from healthy patients in the same period were selected for ...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Upregulation of contactin-1 expression promotes prostate cancer progression.
Authors: Wang B, Yang X, Zhao T, Du H, Wang T, Zhong S, Yang B, Li H Abstract Contactin-1 (CNTN-1) has been reported to serve an oncogenic role in several cancer types. However, detailed mechanisms describing the influence of CNTN-1 in prostate cancer progression have not yet been elucidated. The present study aimed to determine the clinical significance of CNTN-1 expression in prostate cancer progression, and also to investigate the regulatory role of CNTN-1 in the proliferation, migration and invasive ability of prostate cancer cells. The results of the present study indicated that expression levels of CNTN-1 wer...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.
Authors: Wang X, Dong Y, Wu Q, Lu T, Wang Y, Liu W, Liu C, Xu W Abstract As the most common type of cancer in female patients, the morbidity and mortality rates of breast cancer (BC) are high, and its incidence is gradually increasing worldwide. However, the underlying molecular and genetic mechanisms involved in the etiopathogenesis of BC remain unclear. Circular RNAs (circRNAs) are a novel type of non-coding RNAs that have been verified to serve a crucial role in tumorigenesis. However, the majority of functions and mechanisms of circRNAs remain unknown. The present study identified 47 differentially expressed ci...
Source: Oncology Letters - February 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Biology and pathogenesis of human osteosarcoma.
Authors: de Azevedo JWV, de Medeiros Fernandes TAA, Fernandes JV, de Azevedo JCV, Lanza DCF, Bezerra CM, Andrade VS, de Araújo JMG, Fernandes JV Abstract Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring during the rapid growth phase of long bones, and usually located in the epiphyseal growth plates of the femur or the tibia. Its most common feature is genome disorganization, aneuploidy with chromosomal alterations, deregulation of tumor suppressor genes and of the cell cycle, and an absence of DNA repair. This suggests the involvement of surveillance failures, DNA repair or ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Molecular cytogenetic pilot study on pleomorphic adenomas of salivary glands.
In conclusion, approaches utilized in the current study are highly suited to characterize the genetic constitution of PAs. PMID: 31966040 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1.
Long non-coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1. Oncol Lett. 2020 Feb;19(2):1131-1136 Authors: Zhou T, Wu L, Zong Z, Ma N, Li Y, Jiang Z, Wang Q, Chen S Abstract Long non-coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer in humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation of lncRNA MORT in the tumor tissues of patients with colon cancer. The expression of MORT in tumor tissues was linearly associated ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Targeted molecular profiling of genetic alterations in colorectal cancer using next-generation sequencing.
Authors: Luo J, Zhang S, Tan M, Li J, Xu H, Tan Y, Huang Y Abstract Colorectal cancer (CRC) is a major contributor to cancer-associated mortality in China and remains a vast challenge worldwide. Although the genetic basis of CRC has been investigated, the uncommonly mutated genes in CRC remain unknown, in particular in the Asian population. In the present study, targeted region sequencing on 22 CRC and 10 paired non-cancerous tissues was performed to determine the genetic pattern of CRC samples in the Chinese population. Driver genes were detected by three distinct softwares, including MutSigCV, oncodriveFM and iCA...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN.
In conclusion, NR2F2-AS1 downregulation decreased proliferation and increased apoptosis of NPC cells via upregulation of PTEN. PMID: 31966043 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the PI3K/AKT signaling pathway.
Authors: Wang Z, Shen Z, Wang H, Zhang L, Dong R Abstract Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway was investigated. A total of 110 patients who were diagnosed and underwent radical gastrectomy in Ruijin Hospital North, Shanghai Jiaotong University School of Medicine from July 2016 to July 2018 were selected. In the experimental group, 60 patients were treated with dexmedetomidine infusion. In the control group, 50 patients were injected with 0.9% sodium chloride injection during the sam...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of LINC01140 is associated with adverse features of breast cancer.
Authors: Li D, Li L, Cao Y, Chen X Abstract Breast cancer (BC) is one of the most dangerous malignant diseases among women. A growing amount of evidence has suggested that long non-coding RNAs participate in the development and progression of BC and may potentially serve as therapeutic targets or prognostic markers for the disease. A previous study demonstrated that long intergenic non-protein coding RNA 01140 (LINC01140) was prominently correlated with overall survival in patients with gastric cancer. However, the function of LINC01140 in BC has not yet been elucidated. Therefore, the present study aimed to invest...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Diagnostic accuracy of urinary survivin mRNA expression detected by RT-PCR compared with urine cytology in the detection of bladder cancer: A meta-analysis of diagnostic test accuracy in head-to-head studies.
Authors: Fu L, Zhang J, Li L, Yang Y, Yuan Y Abstract Survivin is a promising marker for the diagnosis of bladder cancer. The accuracy and clinical value of urinary survivin mRNA expression were compared with urine cytology, which is the standard diagnostic method for bladder cancer. Scientific databases, including PubMed, Web of Science, Cochrane Library and China National Knowledge Infrastructure, were searched in order to find studies that examined urinary survivin mRNA expression and urine cytology in the diagnosis of bladder cancer. Quality assessment was performed using the Quality Assessment of Diagnostic Ac...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Time-series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma.
Authors: Qi F, Wang L, Huang P, Zhao Z, Yang B, Xia J Abstract Cytokines play an important role in the development of tumors. The purpose of the present study was to evaluate the mechanisms and cytokine level changes after transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). The Short Time-series Expression Miner (STEM) program was utilized to cluster cytokine expression profiles from the day before TACE to day 21 post-TACE. Based on the identified significant signatures, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed. Cytokines were...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus and gastric cancer.
Authors: Liu J, Yang L Abstract Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC) were investigated. One hundred and ten patients with T2DM and GC, treated in The First Affiliated Hospital of Baotou Medical College (Baotou, China) from January 2017 to December 2018, were selected. Sixty patients anesthetized by propofol were included in the propofol group, whereas 50 patients anesthetized by sevoflurane were included in the sevoflurane group. The level of blood glucose, hemodynamic indicators, and inf...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of miR-129-3p on biological functions of prostate cancer cells through targeted regulation of Smad3.
Authors: Jia Y, Gao Y, Dou J Abstract Effects of miR-129-3p on the biological functions of prostate cancer cells through the targeted regulation of Smad3 were investigated. RT-PCR was used to detect the expression levels of miR-129-3p in prostate cancer tissues and cells and its target gene Smad3 mRNA determined by bioinformatics prediction. Correlation between miR-129-3p and Smad3 was analyzed. MTT assay, cell invasion detection, and apoptosis detection were conducted to detect the effects of miR-129-3p and Smad3 on the proliferation, invasion, and apoptosis of prostate cancer cells. The results of RT-qPCR showed ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of hub genes on the clinicopathological and prognostic features of lung adenocarcinoma.
In conclusion, one module and nine genes were recognized to be associated with the tumor stage of LUAD. These findings may enhance the understanding of the progression and prognosis of LUAD. PMID: 31966050 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of osteosarcoma driver genes using a network method.
Authors: Si Z, Hu K Abstract Osteosarcoma (OS) is a severe disease that is generally caused by genetic alterations. Systematic identification of driver genes may be used to increase the understanding of the mechanisms underlying the disease. The present study identified a framework to predict driver genes, with the hypothesis that driver genes operate through a number of connected functional genes. OS-related genes were extracted from the Catalogue Of Somatic Mutations In Cancer and subsequently ranked by virtue of their effect on a set of functional genes using a network-based algorithm. This revealed the driver g...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

PD-L1 gene promoter methylation represents a potential diagnostic marker in advanced gastric cancer.
In conclusion, high methylation levels of the PD-L1 promoter region may be a faciliatory mechanism enabling gastric cancer tumorigenesis, and may also represent an independent prognostic factor for chemotherapeutic efficacy in patients with advanced gastric cancer. PMID: 31966052 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression levels of ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis.
Authors: Zhu H, Qu Y Abstract Expression levels of autophagy-related genes ARHI and Beclin1 in thyroid cancer and their relationship with clinical pathology and prognosis were investigated. The expression levels of ARHI and Beclin1 proteins in 80 cases of thyroid cancer and adjacent tissues were detected by western blot analysis. According to the expression levels of ARHI and Beclin1, low- and high-expression groups were determined and the relationship of the expression levels with the pathological parameters and prognosis in thyroid cancer was compared between the two groups. The correlation between the ARHI and B...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

BMP4 induces asymmetric cell division in human glioma stem-like cells.
Authors: Koguchi M, Nakahara Y, Ito H, Wakamiya T, Yoshioka F, Ogata A, Inoue K, Masuoka J, Izumi H, Abe T Abstract Glioblastoma (GBM) is a malignant tumor with a high recurrence rate and has very poor prognosis in humans. The median survival is still
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA TTN-AS1 promotes breast cancer cell migration and invasion via sponging miR-140-5p.
Authors: Xue J, Zhang Z, Li X, Ren Q, Wang Q Abstract Breast cancer (BC) is one of the most common fatal cancers. Recent studies have identified the vital role of long non-coding RNAs (lncRNAs) in the development and progression of BC. In this investigation, lncRNA TTN-AS1 was studied to identify its function in the metastasis of BC. TTN-AS1 expression of tissues was detected by real-time quantitative polymerase chain reaction (RT-qPCR) in 56 BC patients. Wound healing assay and transwell assay were used to observe the biological behavior changes of BC cells through gain or loss of TTN-AS1. In addition, luciferase ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Regulation of lncRNA PVT1 on miR-125 in metastasis of gastric cancer cells.
Authors: Niu J, Song X, Zhang X Abstract Regulation of long non-coding RNA (lncRNA) PVT1 on miR-125 affecting the metastasis of gastric cancer cells and the mechanism were investigated. qPCR was used to detect the expression of PVT1 and miR-125 in gastric cancer and paracancerous tissues, and the relationship between PVT1 and clinicopathological parameters of gastric cancer patients. Dual luciferase reporter gene was used to detect the mutual effect between PVT1 and miR-125. The clone formation assay was used to detect changes of proliferation behavior of gastric cancer cells after inhibition of PVT1. Transwell inv...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of miR-34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis.
Authors: Wei L, Shi C, Zhang Y Abstract Expression levels of miR-34a and Ki67 in nasopharyngeal carcinoma (NPC) and the relationship with clinicopathological features and prognosis were studied. A prospective study was performed on 56 cases of NPC tissues and 56 cases of adjacent tissues collected in Xiangyang No. 1 People's Hospital. The expression levels of miR-34a, Ki67 in NPC and adjacent tissues were detected by RT-qPCR. The association among the expression levels of miR-34a and Ki67, the clinicopathological features and prognosis of patients was analyzed. The relative expression levels of miR-34a in 56 cases ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer.
In conclusion, the expression levels of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer tissues are consistent and different. The expression levels of WWOX and Elf5 are related to the survival and prognosis of patients with epithelial ovarian cancer. PMID: 31966058 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Bone morphogenic proteins-2, -4, -6 and 7 in non-muscle invasive bladder cancer.
In conclusion, BMP-2 and -7 are potential prognostic factors for tumor recurrence and further studies on BMP and bladder cancer are needed to confirm these results. PMID: 31966059 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Involvement of the TGF- β1 pathway in caveolin-1-associated regulation of head and neck tumor cell metastasis.
Involvement of the TGF-β1 pathway in caveolin-1-associated regulation of head and neck tumor cell metastasis. Oncol Lett. 2020 Feb;19(2):1298-1304 Authors: Sun J, Lu Y, Yu C, Xu T, Nie G, Miao B, Zhang X Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent malignancy with a 5-year survival rate of 54%. Therefore, disease management improvement is required. The present study aimed to assess the role of caveolin-1 (Cav-1) in the metastasis of head and neck tumor cells. Short hairpin RNA was used to silence Cav-1 expression in Tu686 cells. Proliferation, migration, invasi...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

mi-R4435-2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2.
Authors: Hu J, Wang L, Zhao W, Huang Y, Wang Z, Shen H Abstract The present study aimed to investigate the involvement of long noncoding RNA mi-R4435-2HG in ovarian carcinoma. mi-R4435-2HG and Rho-associated protein kinase 2 (ROCK2) were demonstrated to both be upregulated in ovarian carcinoma. mi-R4435-2HG and ROCK2 were positively correlated in both tumor and healthy tissues. mi-R4435-2HG overexpression mediated the upregulation of ROCK2, while upregulation of ROCK2 did not affect mi-R4435-2HG. Overexpression of mi-R4435-2HG and ROCK2 led to promoted proliferation and inhibited apoptosis of cancer cells, while mi...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Influence of miR-101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway.
Authors: Meng X, Shi Y, Xiang X, Li C, Ge X, Pan K, Liang Y Abstract The expression of miR-101 in carcinoma and para-carcinoma tissues of patients with liver cancer was studied. The carcinoma and para-carcinoma tissues of 67 patients with liver cancer treated in Chinese PLA General Hospital were collected, and the expression of miR-101 in carcinoma and para-carcinoma tissues was detected via reverse transcription-polymerase chain reaction (RT-PCR). The liver cancer HepG2 cell line was transfected with miR-101 mimics. Moreover, the influence of miR-101 overexpression on the proliferation of liver cancer cells was de...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Evaluation of azacitidine in patients with transplant-ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia-related changes in a Japanese clinical setting.
In conclusion, AZA could produce a hematologic response in ~53% of patients with MDS. Furthermore, IPSS-R may reflect MDS prognosis. Further studies are required to establish the criteria for identifying patients likely to obtain maximum benefit from AZA treatment. PMID: 31966063 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR.
Authors: Yin N, Xie T, Zhang H, Chen J, Yu J, Liu F Abstract Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated gene in World Health Organization grade II-III and secondary glioma. The majority of IDH1 mutation cases involve the substitution from arginine to histidine at codon 132 (IDH1-R132H). Although the oncogenic role of IDH1-R132H has been confirmed, patients with IDH1-R132H brain tumors exhibit a better response to radiotherapy compared with those with wild-type (WT) IDH1. In the present study, the potential mechanism of radiosensitization mediated by IDH1-R132H was investigated by overexpressin...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer.
This study also demonstrated that alterations in small molecule metabolites in the urine of patients with BC were very similar to results from a previous report. These findings indicated that environmental exposure to Cd, As, or Cr could influence the urine levels of metabolites, which may be involved in BC development. Further investigation is therefore required to examine a larger range of samples from different countries or areas in order to understand the impact of heavy metals on metabolism and BC development. PMID: 31966065 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Glucose restriction combined with chemotherapy decreases telomere length and cancer antigen-125 secretion in ovarian carcinoma.
In conclusion, the combination of chemotherapy and glucose restriction was observed to decrease Ca-125 secretion and telomerase expression leading to shortening in telomere length. Thus, decreasing glucose availability for OC cells during treatment may lead to a better clinical outcome and potentially improve the prognosis of patients with OC. PMID: 31966066 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes.
Authors: Guan E, Tian F, Liu Z Abstract Stomach adenocarcinoma (STAD) accounts for 95% of cases of malignant gastric cancer, which is the third leading cause of cancer-associated mortality worldwide. The pathogenesis and effective diagnosis of STAD have become popular topics for research in the previous decade. In the present study, high-throughput RNA sequencing expression profiles and clinical data from patients with STAD were obtained from The Cancer Genome Atlas database and were used as a training dataset to screen differentially expressed genes (DEGs). Prognostic DEGs were identified using univariate Cox regr...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Centromere protein F and Forkhead box M1 correlation with prognosis of non-small cell lung cancer.
In conclusion, our study provides evidence of the prognostic function of CENPF in NSCLC. PMID: 31966068 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Integrated bioinformatics analysis to screen hub genes in the lymph node metastasis of thyroid cancer.
Authors: Lu S, Zhao R, Shen J, Zhang Y, Shi J, Xu C, Chen J, Lin R, Han W, Luo D Abstract Thyroid cancer (TC) is one of the most common types of malignancy of the endocrine-system. At present, there is a lack of effective methods to predict neck lymph node metastasis (LNM) in TC. The present study compared the expression profiles from The Cancer Genome Atlas between N1M0 and N0M0 subgroups in each T1-4 stages TC in order to identify the four groups of TC LNM-associated differentially expressed genes (DEGs). Subsequently, DEGs were combined to obtain a total of 493 integrated DEGs by using the method of Robust Rank ...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC.
Authors: Lou M, Gao Z, Zhu T, Mao X, Wang Y, Yuan K, Tong J Abstract As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to investigate the expression and prognostic value of TRIM59 in patients with non-small cell lung cancer (NSCLC). Expression of TRIM59 in patients with NSCLC was measured by immunohistochemistry in tissue microarrays. Datasets from The Cancer...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-519 inhibits hypoxia-induced tumorigenesis of pancreatic cancer by regulating immune checkpoint PD-L1.
Authors: Nong K, Zhang D, Chen C, Yang Y, Yang Y, Liu S, Cai H Abstract Pancreatic cancer is highly prevalent and exhibits a high incidence and mortality rate. Hypoxia contributes to tumorigenesis and the progression of pancreatic cancer. To the best of our knowledge, the role of microRNA (miR)-519 has not been investigated in hypoxia-induced pancreatic cancer progression. The purpose of the present study was to elucidate the mechanism underlying miR-519-mediated regulation of pancreatic cancer progression. Reverse transcription-quantitative PCR and western blotting were performed to investigate miR-519 and program...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Bioinformatics analysis of esophageal cancer unveils an integrated mRNA-lncRNA signature for predicting prognosis.
Authors: Lan T, Xiao Z, Luo H, Su K, Yang O, Zhan C, Lu Y Abstract Esophageal cancer (ESCA) carries a poor prognosis among gastrointestinal malignancies. The present study developed a signature based on mRNAs and long non-coding RNAs (lncRNAs) to predict prognosis in ESCA by using The Cancer Genome Atlas database. By using least absolute shrinkage and selection operator penalized regression, a set of RNAs (three mRNAs and two lncRNAs) was identified and used to build a risk score system of ESCA prognosis, which was used to stratify patients having considerable diverse survival in the training set [hazard ratio (HR)...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA expression identified by microarray analysis: Candidate biomarkers in human acral lentiginous melanoma.
Authors: Shi HZ, Xiong JS, Xu CC, Bu WB, Wang Y, Sun JF, Chen H Abstract Melanoma is a rare but fatal form of skin cancer and acral lentiginous melanoma (ALM) is one of its most common types. Long non-coding RNA (lncRNA) has emerged as a crucial molecule in the development and progression of human cancers, and several studies have revealed that lncRNAs may be associated with the pathogenesis, progression and metastasis of melanoma. To demonstrate the association between ALM and lncRNAs, microarray analysis was performed in tumor and adjacent non-tumor tissues. A total of 4,488 lncRNAs and 3,913 mRNAs were identifie...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Tracking the important role of JUNB in hepatocellular carcinoma by single-cell sequencing analysis.
Authors: Yan P, Zhou B, Ma Y, Wang A, Hu X, Luo Y, Yuan Y, Wei Y, Pang P, Mao J Abstract Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer, accounting for ~90% of all primary malignancy of the liver. Although various medical treatments have been used as systemic therapies, patient survival time may be extended by only a few months. Moreover, the underlying mechanisms of HCC development and progression remain poorly understood. In the present study, the single-cell transcriptome of one in vivo HCC tumor sample, two in vitro HCC cell lines and normal peripheral blood mononuclear cells were an...
Source: Oncology Letters - January 24, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research