Multi-omics integrative analysis and survival risk model construction of non-small cell lung cancer based on The Cancer Genome Atlas datasets.
Authors: Luan M, Song F, Qu S, Meng X, Ji J, Duan Y, Sun C, Si H, Zhai H Abstract Lung cancer is a major cause of cancer-associated mortality worldwide. However, the association between multi-omics data and survival in lung cancer is not fully understood. The present study investigated the performance of the methylation survival risk model in multi-platform integrative molecular subtypes and aimed to identify copy number (CN) variations and mutations that are associated with survival risk. The present study analyzed 439 lung adenocarcinoma cases based on DNA methylation, RNA, microRNA (miRNA), DNA copy number and m...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

18F-FDG PET/CT SUVmax and serum CEA levels as predictors for EGFR mutation state in Chinese patients with non-small cell lung cancer.
Authors: Gao XC, Wei CH, Zhang RG, Cai Q, He Y, Tong F, Dong JH, Wu G, Dong XR Abstract The epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) contribute to an increased response rate, compared with chemotherapy, in patients with inhibitor-sensitive EGFR mutations. The present study evaluated the association between the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT), as well as serum carcinoembryonic antigen (CEA) levels and EGFR mutations prior to treatment, in patients with non-small cell lung cancer (NSCLC). ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression.
Authors: Yang Z, Xu JX, Fang DP, Ke J Abstract Prostate cancer (PCa) is one of the most common types of cancer in males globally. However, the molecular mechanisms underlying PCa progression remain largely unclear. In the present study, Gene Expression Omnibus (GEO) datasets and datasets from The Cancer Genome Atlas (TCGA) were used to analyze the expression of lysine demethylase 5B (KDM5B) in PCa. Proliferation, cell cycle and migration assays were used to detect the functional roles of KDM5B. It was found KDM5B was upregulated in PCa tissues by analyzing GEO and TCGA datasets. KDM5B knockdown significantly suppre...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Comprehensive analysis of a long non-coding RNA-associated competing endogenous RNA network in glioma.
Authors: Zhu J, Wang H, Huang YQ, Song W, Li YF, Wang WJ, Ding ZL Abstract Long non-coding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs), interacting with microRNAs (miRNAs) and playing an important role in tumor progression. However, the role of lncRNA-mediated ceRNAs in glioma remains largely unknown. The present study aimed to identify novel lncRNAs and their associated function in glioma. RNA sequencing and corresponding clinical data from patients with glioma were obtained from The Cancer Genome Atlas. A total of 598 glioma tissues and 5 normal brain tissues were analyzed in the present study. T...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Anticancer effects and the mechanism underlying 2-methoxyestradiol in human osteosarcoma in vitro and in vivo.
Authors: Tang X, Tao F, Xiang W, Zhao Y, Jin L, Tao H Abstract Osteosarcoma (OS) occurs in both children and adolescents and leads to a poor prognosis. 2-methoxyestradiol (2-ME) has a strong antitumor effect and is effective against numerous types of tumor. However, 2-ME has a low level of antitumor effects in OS. The present study investigated the effects of 2-ME on the proliferation and apoptosis of human MG63 OS cells. The potential biological mechanisms by which 2-ME exerts its biological effects were also investigated in the present study. The results of the present study demonstrated that 2-ME inhibited the p...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Aberrant allelic-switch of antisense lncRNA IRAIN may be an early diagnostic marker in laryngeal cancer.
Authors: Wang JY, Liu D, Di Meng Y, Guo YY, Zhao M Abstract Laryngeal carcinoma is a common head and neck malignancy, however, the molecular mechanism of the disease has not yet been elucidated. The present study aimed to investigate the role of IGF1R antisense imprinted non-protein coding RNA (IRAIN) long non-coding (lnc)RNA in laryngeal carcinoma. In total, specimens of healthy pharynx tissue from 6 healthy individuals, carcinoma tissue and paracancerous tissue from 37 patients with laryngeal carcinoma were used in this study. The single nucleotide polymorphism (SNP) rs8034564 was used to distinguish the two pare...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effect of alkylglycerone phosphate synthase on the expression levels of lncRNAs in glioma cells and its functional prediction.
In conclusion, the findings of the present study suggested that AGPS may affect cell proliferation and the degree of malignancy. In addition, the identified lncRNAs and their co-expressed mRNAs screened using microarrays may have significant biological effects in the occurrence, development and metastasis of glioma, and thus may be novel markers of glioma. PMID: 32863899 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF- κB signaling pathway.
In conclusion, the results of the present study indicated that MCL may inhibit glioma carcinoma growth by downregulating the NF-κB/COX-2 signaling pathway, which suggested that MCL may be a novel and alternative antitumor agent for the treatment of human glioma carcinoma. PMID: 32863900 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels.
In conclusion, miR-30 family members inhibited EMT of NSCLC cells, partially via suppressing XB130 expression levels. PMID: 32863901 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-548ac induces apoptosis in laryngeal squamous cell carcinoma cells by targeting transmembrane protein 158.
Authors: Song F, Yang Y, Liu J Abstract Laryngeal cancer is a common head and neck cancer that effects the quality of life of those affected. Early diagnosis and treatment are vital to minimize the harmful effects of laryngeal cancer, which can improve the survival rate of patients following surgery and retain the voice function of the larynx. The purpose of the present study was to explore the molecular mechanism of the development of laryngeal cancer and to determine the biomarker for the diagnosis and treatment of laryngeal cancer. Reverse transcription-quantitative PCR (RT-qPCR) and The Cancer Genome Atlas data...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma.
Authors: Chen J, Cao J, Wang P, He X Abstract Reliable biomarkers for the prognosis of hepatocellular carcinoma (HCC) are rare, and novel biomarkers are required for the appropriate management of HCC. 5'-Nucleotidase domain containing 2 (NT5DC2) acts as an oncogene in various tumors, but its functions as a biomarker have not been confirmed. Therefore, the present study aimed to resolve these functions by analyzing the prognostic value of NT5DC2 in patients with HCC. A tissue microarray (TMA) was prepared and NT5DC2 expression was measured via IHC staining in TMA dots. The liver cancer (LIHC) cohort in The Cancer Ge...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G2/M cell cycle arrest and apoptosis.
Authors: Lei Y, Gan H, Huang Y, Chen Y, Chen L, Shan A, Zhao H, Wu M, Li X, Ma Q, Wang J, Zhang E, Zhang J, Li Y, Xue F, Deng L Abstract Hepatocellular carcinoma (HCC) remains a challenge in the medical field due to its high malignancy and mortality rates particularly for HCC, which has developed multidrug resistance. Therefore, the identification of efficient chemotherapeutic drugs for multidrug resistant HCC has become an urgent issue. Natural products have always been of significance in drug discovery. In the present study, a cell-based method was used to screen a natural compound library, which consisted of 78 ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation.
Authors: Chandrasekaran AP, Poondla N, Ko NR, Oh SJ, Ramakrishna S Abstract Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis is a safe method for the treatment of various types of cancer. However, TRAIL therapy is less effective in certain types of cancer, including cervical cancer. To address this problem, a combinatorial approach was employed to sensitize cervical cancer at low dosages. YM155, a survivin inhibitor, was used at low dosages along with TRAIL to induce apoptosis in HeLa cells. The effects of the individual treatment with TRAIL and YM155 on apoptosis were assessed by ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Triclosan induces ROS-dependent cell death and autophagy in A375 melanoma cells.
Authors: Jin J, Chen N, Pan H, Xie W, Xu H, Lei S, Guo Z, Ding R, He Y, Gao J Abstract Melanoma is a common type of cutaneous tumor, but current drug treatments do not satisfy clinical practice requirements. At present, mitochondrial uncoupling is an effective antitumor treatment. Triclosan, a common antimicrobial, also acts as a mitochondrial uncoupler. The aims of the present study were to investigate the effects of triclosan on melanoma cells and the underlying mechanisms. Mitochondrial membrane potential (MMP), mitochondrial morphology, mitochondrial reactive oxygen species (mito-ROS), intracellular superoxide ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-642 serves as a tumor suppressor in hepatocellular carcinoma by regulating SEMA4C and p38 MAPK signaling pathway.
Authors: Yu Z, Du Y, Li H, Huang J, Jiang D, Fan J, Shen Y, Zhang L, Yu X, Xu N, Ke Q Abstract Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and high risk. Study of the role and mechanism of miRNAs are a hot spot of research providing new treatment ideas in malignant tumors. The effect of miR-642a on HCC progression and the underlying molecular mechanism were investigated. Expression of miR-642a and SEMA4C was measured by western blot analysis and RT-PCR. miR-642a expression was elevated while SEMA4C expression was attenuated in HCC tissues and cells. Results of luciferase reporter and wes...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Contrast-enhanced ultrasound for needle biopsy of thoracic lesions.
Authors: Liang J, Wang D, Li H, Zhao S, Chen M, Li H, Ding Z, Liu J, Liu L Abstract Two-dimensional ultrasound (US) and color doppler flow imaging are associated with certain limitations in the preprocedural evaluation and design of the puncture path for biopsies of thoracic lesions, such as a poorly defined boundary between the tumor and the atelectatic lesions in central lung cancer with atelectasis. Contrast-enhanced ultrasound (CEUS) can be valuable in the preoperative evaluation of the biopsy site and in increasing the accuracy of the biopsy. The present study investigated the value of clinical application of ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

GLI1 activation is a key mechanism of erlotinib resistance in human non-small cell lung cancer.
Authors: Dong Z, Wang Y, Ding V, Yan X, Lv Y, Zhong M, Zhu F, Zhao P, He C, Ding F, Shi H Abstract Lung cancer is the leading cause of cancer-associated death worldwide. In recent years, the advancement of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) targeted therapies has provided clinical benefits for lung cancer patients with EGFR mutations. The response to EGFR-TKI varies in patients with lung cancer, and resistance typically develops during the course of the treatment. Therefore, understanding biomarkers which can predict resistance to EGFR-TKI is important. Overexpression of GLI cause...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Intranasal dexmedetomidine combined with local anesthesia for conscious sedation during breast lumpectomy: A prospective randomized trial.
Authors: Yuan YJ, Zhou P, Xia F, Zhang XB, He SS, Guo DY, Xing YH, Zhao HW Abstract Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious sedation with intranasal dexmedetomidine combined with local anesthesia in breast lumpectomy, and to identify its optimal dose. A prospective randomized, double-blinded, placebo-controlled, single-center study was desig...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Detection of circulating tumor cells in patients with breast cancer using the conditionally reprogrammed cell culture method and reverse transcription-PCR of hTERT and MAGE A1-6.
In conclusion, the present study revealed the potential of CRC culture in the detection of CTCs in breast cancer. Furthermore, a combination of CRC culture and RT-PCR for the hTERT and MAGE A1-6 genes is useful in enhancing the detection rate of CTCs in the blood. PMID: 32863911 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

LncRNA-zinc finger protein 281 downregulates rho-associated coiled-coil containing protein kinase 1 by upregulating miR-144 in osteosarcoma.
Authors: Shao Y, Tong Z, Wei J, Yang T Abstract Zinc finger protein 281 (ZNF281) has been characterized as a tumor suppressive lncRNA in glioma. The present study aimed to analyze the functionality of ZNF281 in osteosarcoma (OS). It was demonstrated that ZNF281 was downregulated in OS tissue specimens and predicted the survival of patients with OS. In tissues from patients with OS, ZNF281 was negatively associated with rho-associated coiled-coil containing protein kinase 1 (ROCK1), but positively associated with miR-144. In the U2OS cell line, ZNF281 overexpression mediated the upregulation of miR-44 and downregula...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-375-3p inhibits the progression of laryngeal squamous cell carcinoma by targeting hepatocyte nuclear factor-1 β.
miR-375-3p inhibits the progression of laryngeal squamous cell carcinoma by targeting hepatocyte nuclear factor-1β. Oncol Lett. 2020 Oct;20(4):80 Authors: Chang K, Wei Z, Cao H Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most frequently diagnosed head and neck cancers worldwide. Increasing evidence suggests that microRNAs (miRNAs/miRs) regulate the progression of tumorigenesis and the malignant behaviors of cancer cells. The aim of this study was to investigate the function and underlying mechanism of miR-375-3p in LSCC. The expression of miR-375-3p in LSCC tissues and cells wa...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Eukaryotic translation initiation factor 5A in the pathogenesis of cancers.
Authors: Ning L, Wang L, Zhang H, Jiao X, Chen D Abstract Cancer is the leading cause of death worldwide. The absence of obvious symptoms and insufficiently sensitive biomarkers in early stages of carcinoma limits early diagnosis. Cancer therapy agents and targeted therapy have been used extensively against tissues or organs of specific cancers. However, the intrinsic and/or acquired resistance to the agents or targeted drugs as well as the serious toxic side effects of the drugs would limit their use. Therefore, identifying biomarkers involved in tumorigenesis and progression represents a challenge for cancer diag...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer.
Authors: Tanaka Y, Murayama Y, Matsumoto T, Kubo H, Harada K, Matsuo H, Kubota T, Okamoto K, Otsuji E Abstract 5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is a minimally invasive therapeutic modality used in the management of various cancers, but to a lesser extent for esophageal cancer (EC). The current study investigated the antitumor effects of ALA-PDT. Human EC cells were treated with ALA, after which ALA-induced fluorescence was examined under a fluorescence microscope. The cytotoxic effects of ALA-PDT were assessed using three types of LEDs (blue, green and red) in vitro and in vivo. Subcuta...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Roles of long non-coding RNAs in the hallmarks of glioma.
Authors: Xue BZ, Xiang W, Zhang Q, Wang YH, Wang HF, Yi DY, Xiong NX, Jiang XB, Zhao HY, Fu P Abstract Glioma is one of the most common types of tumor of the central nervous system. Due to the aggressiveness and invasiveness of high-level gliomas, the survival time of patients with these tumors is short, at ~15 months, even after combined treatment with surgery, radiotherapy and/or chemotherapy. Recently, a number of studies have demonstrated that long non-coding RNA (lncRNAs) serve crucial roles in the multistep development of human gliomas. Gliomas acquire numerous biological abilities during multistep developmen...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Markers of epithelial-mesenchymal transition in an experimental breast cancer model induced by organophosphorous pesticides and estrogen.
Authors: Calaf GM, Bleak TC, Muñoz JP, Aguayo F Abstract Breast cancer is a major health problem and accounted for 11.6% of all new cancer cases and 6.6% of all cancer deaths among women worldwide in 2018. However, its etiology has remained elusive. According to epidemiological studies, environmental factors are influencing the increase in the incidence of breast cancer risk. Components such as chemicals, including pesticides, are agents that produce deleterious effects on wildlife and humans. Among them, the organophosphorus pesticides, such as malathion, have largely been considered in this etiology. The e...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of ZNF365 by methylation predicts poor prognosis in patients with colorectal cancer by decreasing phospho-p53 (Ser15) expression.
Authors: Wang C, Liu S, Kuang Y, Hu X, Fang X Abstract ZNF365 is a transcription factor that plays important roles in different types of cancer, such as colorectal cancer, breast cancer and hepatocellular carcinoma. ZNF365 can promote stalled replication fork recovery to prevent genomic instability, which is a notable feature of sporadic and hereditary types of cancers. However, the function of ZNF365 in the tumor progression of colorectal cancer (CRC) remains unclear. Thus, immunohistochemical staining was used to investigate the association between ZNF365 expression and the clinicopathological characteristics of ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

p62 overexpression promotes neoplastic stromal cell proliferation and is associated with the recurrence of giant cell tumor of bone.
Authors: Liu S, Ye F, Li D, He C, He H, Zhang J Abstract Giant cell tumor of bone (GCTB) is an intermediate (locally aggressive) bone tumor with a recurrence rate of>30% following surgery. GCTB recurrence is ultimately due to the proliferation of neoplastic stromal (NS) cells. However, the precise mechanism underlying the regulation of NS cell proliferation remains unknown. p62 protein is a multifunctional adaptor protein that exerts a positive role in bone tumors and metabolic bone diseases. In the present study, the mRNA and protein expression levels of p62 were detected by reverse transcription-quantitative P...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Impact of molecular subtypes on metastatic behavior and overall survival in patients with metastatic breast cancer: A single-center study combined with a large cohort study based on the Surveillance, Epidemiology and End Results database.
In conclusion, the results of the present study suggested that different molecular subtypes of breast cancer have different metastatic behavior, as well as mean OS. PMID: 32863920 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial-to-mesenchymal transition.
Authors: Xu W, Sun X, Zang C, Jiang Y Abstract [This retracts the article DOI: 10.3892/ol.2020.11397.]. PMID: 32863921 [PubMed - in process] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Erratum: P21 activated kinase 2 promotes pancreatic cancer growth and metastasis.
Authors: Yao GW, Bai JR, Zhang DP Abstract [This corrects the article DOI: 10.3892/ol.2019.10040.]. PMID: 32863922 [PubMed - in process] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

TLR9 induces colitis-associated colorectal carcinogenesis by regulating NF- κB expression levels.
In conclusion, the findings of the present study suggested that TLR9 may serve an important role in the development of CAC by regulating NF-κB signaling. PMID: 32863923 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.
Authors: Cai X, Hu B, Liu S, Liu M, Huang Y, Lei P, Zhang Z, He Z, Zhang L, Huang R Abstract Drug resistance leads to tumor relapse and further progression during chemotherapy in lung cancer. Close homolog of L1 (CHL1) has been identified as a tumor suppressor in most malignancies. However, to the best of our knowledge, whether CHL1 mediates chemoresistance remains unknown. The present study observed that CHL1 was significantly downregulated in cisplatin (DDP)-resistant cells (A549/DDP) and paclitaxel (PTX)-resistant cells (A549/PTX) compared with A549 cells. When treated with or without DDP and PTX, silencing of C...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis.
Authors: Liu L, Yan Z, Wang Y, Meng J, Chen G Abstract Our previous study found that hydrogen gas (H2) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. The present study aimed to explore the roles of H2 in lung cancer cell autophagy, and reveal the effects of autophagy on H2-mediated lung cancer cell apoptosis and the underlying mechanisms. The expression levels of proteins associated with cell apoptosis and autophagy were detected using western blot analysis. Cell autophagy was inhibited by 3-methyladenine treatment or Beclin1 downregulation, whi...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Artificial classification of cervical squamous lesions in ThinPrep cytologic tests using a deep convolutional neural network.
Authors: Liu L, Wang Y, Ma Q, Tan L, Wu Y, Xiao J Abstract The diagnosis of squamous cell carcinoma requires the accurate classification of cervical squamous lesions in the ThinPrep cytologic test (TCT). It primarily relies on a pathologist's interpretation under a microscope. Deep convolutional neural networks (DCNN) have played an increasingly important role in digital pathology. However, they have not been applied to diverse datasets and externally validated. In the present study, a DCNN model based on VGG16 and an ensemble training strategy (ETS) based on 5-fold cross-validation was employed to automatically cl...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

DEFB4A is a potential prognostic biomarker for colorectal cancer.
Authors: Wu Q, Wang D, Zhang Z, Wang Y, Yu W, Sun K, Maimela NR, Sun Z, Liu J, Yuan W, Zhang Y Abstract Colorectal cancer (CRC) is the third leading cause of cancer-associated mortality. The present study aimed to investigate novel biomarkers to predict prognosis and provide a theoretical basis for studies of the pathogenesis and the development of therapies for CRC. The present study compared mRNA expression levels of patients with CRC with short- and long-term prognosis and of individuals with and without tumors in The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were identified via ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy.
Authors: Hu K, Yu W, Ajayi OE, Li L, Huang Z, Rong Q, Wang S, Wu QF Abstract Gastric cancer is a leading cause of cancer-associated deaths worldwide and is considered to be an age-related disease. In younger patients, gastric cancer is biologically more aggressive, and prognosis is worse compared with that in elderly patients. In the present case report, the whole genome and transcriptome was sequenced in a 26-year-old patient with gastric cancer who presented with gastric cancer-related symptoms and was admitted to the First Affiliated Anhui Medical Hospital (Hefei, China) in December 2016. In total, 9 germline an...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Pectolinarigenin inhibits cell viability, migration and invasion and induces apoptosis via a ROS-mitochondrial apoptotic pathway in melanoma cells.
Authors: Deng Y, Zhang Q, Li Y, Wang L, Yang S, Chen X, Gan C, He F, Ye T, Yin W Abstract Pectolinarigenin a plant secondary metabolite that has various biological effects, including the inhibition of melanogenesis and tumor growth. Melanoma has a high degree of malignancy, with rapid metastasis and severe drug resistance, explaining the need for new candidate drugs that inhibit tumor growth and metastasis. However, the pharmacological action and mechanism of pectolinarigenin on the growth and metastasis of melanoma remain elusive. Thus, the present study aimed to investigate the role of pectolinarigenin in melanom...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Features associated with melanoma metastasis in Latvia.
Authors: Pjanova D, Ruklisa D, Kregere E, Azarjana K, Ozola A, Cema I Abstract Cutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective analysis was performed using the archive data of 2,026 patients with CM that were treated at the Riga East University Hospital Latvian Oncology Centre, which is the largest oncological hospital in the country, between 1998 and ...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: A propensity score matched study.
Authors: Chi Q, Shi Z, Zhang Z, Zhang X, Zhang L, Weng S Abstract The incidence of hepatocellular carcinoma (HCC) with bile duct tumour thrombus (BDTT) is low, and related studies, especially studies on long-term survival, are uncommon. The present study aimed to evaluate the clinicopathological characteristics, prognostic factors and postoperative long-term outcomes of BDTT in patients with HCC. The clinicopathological characteristics and postoperative long-term outcomes of patients with HCC both with and without BDTT were compared before and after propensity score matching (PSM). Prognostic risk factors were asse...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of key pathways and genes shared between Crohn's disease and breast cancer using bioinformatics analysis.
Authors: Zhou J, Yang R Abstract Patients with Crohn's disease (CD) have a high risk of developing breast cancer, suggesting that there may be shared molecular mechanisms underlying CD and breast cancer. The purpose of the present study was to identify the critical genes and pathways underlying these molecular similarities using bioinformatics analysis. Publicly available microarray expression data from the Gene Expression Omnibus were analyzed, and a total of 53 overlapping differentially expressed genes (DEGs) between the CD (vs. controls) and breast cancer (vs. controls) groups were identified. These common DEGs...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cyto-biological effects of microRNA-424-5p on human colorectal cancer cells.
Authors: Yan W, Jiang X, Wang G, Li W, Zhai C, Chen S, Shang F, Zhao Z, Yu W Abstract MicroRNA (miR)-424-5p is overexpressed in colorectal cancer (CRC); however, its role, clinical significance and underlying molecular mechanism have remained to be fully elucidated. The aim of the present study was to investigate the roles of miR-424-5p in CRC and the underlying mechanisms. It was demonstrated that miR-424-5p is overexpressed in CRC, based on bioinformatics analysis using The Cancer Genome Atlas TCGA and analysis of tissue samples from patients with CRC from The First Hospital of Hebei Medical University, and the e...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Evodiamine induces reactive oxygen species-dependent apoptosis and necroptosis in human melanoma A-375 cells.
In conclusion, the results of the present study unveiled a novel mechanism of drug action by EVO in human melanoma cells and suggested its potential value in treating human melanoma by inducing cell death via ROS activation. PMID: 32863934 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Dihydrotanshinone I inhibits human glioma cell proliferation via the activation of ferroptosis.
Authors: Tan S, Hou X, Mei L Abstract The aim of the present study was to investigate the effect of dihydrotanshinone I (DHI) on the survival of human glioma cells and the expression levels of ferroptosis-associated proteins. Human U251 and U87 glioma cells were cultured in vitro and treated with different concentrations of DHI and/or the ferroptosis inhibitor ferrostatin-1. A Cell Counting Kit-8 assay was used to determine the cell survival rate. The cells were further analyzed to determine their 5-, 12- and 15-hydroxyeicosatetraenoic acid (HETE), lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels, and r...
Source: Oncology Letters - September 1, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

PARP inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective.
Authors: Loizzi V, Ranieri G, Laforgia M, Gadaleta CD, Gargano G, Kardhashi A, De Liso M, Naglieri E, Del Vecchio V, Cicinelli E, Cormio G Abstract Epithelial ovarian cancer (EOC) has a poor prognosis. Since the introduction of paclitaxel as antineoplastic agent>20 years ago, only a few phase III randomized trials have shown challenging data regarding different therapeutic options for facing its aggressive clinical course and granting active therapies to patients. Different studies have shown the utility of poly(ADP-ribose) polymerase (PARP) inhibitors in women with EOC with or without BRCA mutations, both germl...
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Gamma-irradiation degraded sulfated polysaccharide from a new red algal strain Pyropia yezoensis Sookwawon 104 with in vitro antiproliferative activity.
In conclusion, low-Mw polysaccharide derivatives prepared from P. yezoensis Sookwawon 104 by gamma-irradiation exhibit significant inhibition effects on cancer cell proliferation in vitro and may be a novel source of potential anticancer therapeutic agents. PMID: 32831910 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Comparison of the clinicopathological characteristics and prognosis between Chinese patients with breast cancer with bone-only and non-bone-only metastasis.
Authors: Zhang L, Zhang J, Li Z, Wu Y, Tong Z Abstract Bone is the most common site of metastatic spread in patients with breast cancer. Patients with bone-only metastasis (BOM) are a unique group. The aim of the present study was to compare the clinicopathological characteristics, survival and prognostic factors of patients with BOM and non-BOM. The clinical data of 1,290 patients with metastatic breast cancer treated at the Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) between January 2008 and December 2017 were reviewed. The clinical data were divided into a BOM group (n=208 cases) an...
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of microRNA-130a predicts adverse prognosis of primary gastrointestinal diffuse large B-cell lymphoma.
Authors: Chen L, Kan Y, Wang X, Ge P, Ding T, Zhai Q, Wang Y, Yu Y, Wang X, Zhao Z, Yang H, Liu X, Li L, Qiu L, Zhang H, Qian Z, Zhao H Abstract Primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) is a highly heterogeneous type of non-Hodgkin lymphoma. A number of studies have demonstrated that microRNA-130a (miR-130a) serves a role in the tumorigenesis and prognosis of numerous human tumors. However, to the best of our knowledge, the prognostic significance of miR-130a in PGI-DLBCL remains unknown. The present study explored the association between miR-130a and the clinical outcomes of PGI-DLBCL. Re...
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy.
In conclusion, the present study demonstrated the potential value of DHA in the treatment of EC, and revealed the underlying mechanism by which FDHA inhibits cellular migration. PMID: 32831913 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-490-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells via targeting TMOD3.
In conclusion, the aforementioned results suggest that the overexpression of miR-490-3p inhibited the proliferation and invasion of HCC cells by targeting TMOD3. Therefore, the miR-490-3p/TMOD3 axis may be a potent target for the treatment of HCC. PMID: 32831914 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of miR-218-1-3p and miR-149 on proliferation and apoptosis of non-small cell lung cancer cells.
Authors: Guo P, Sheng M, Liu H, Ju L, Yang N, Sun Y Abstract The aim of the present study was to explore the effects of miR-218-1-3p and miR-149 on the biological function of non-small cell lung cancer (NSCLC) cells A549. Paired NSCLC and adjacent tissues were obtained from 50 NSCLC patients admitted to Shandong Provincial Chest Hospital Affiliated to Shandong University (Jinan, China) from April 2015 to May 2018. The expression levels of miR-218-1-3p and miR-149 were detected by reverse transcription-quantitative PCR (RT-qPCR). The lung adenocarcinoma A549 cells were assigned into the blank group (without transfec...
Source: Oncology Letters - August 26, 2020 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research