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"Oncol Lett"[ta]; +155 new citations
155 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Oncol Lett"[ta] These pubmed results were generated on 2018/01/20PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Oncology Letters)
Source: Oncology Letters - January 20, 2018 Category: Cancer & Oncology Tags: Report Source Type: research

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.
Authors: Choudhry H, Zamzami MA, Omran Z, Wu W, Mousli M, Bronner C, Alhosin M Abstract Ubiquitin-like containing plant homeodomain and RING finger domains 1 (UHRF1) is an anti-apoptotic protein involved in the silencing of several tumor suppressor genes (TSGs) through epigenetic modifications including DNA methylation and histone post-translational alterations, and also epigenetic-independent mechanisms. UHRF1 overexpression is observed in a number of solid tumors and hematological malignancies, and is considered a primary mechanism in inhibiting apoptosis. UHRF1 exerts its inhibitory activity on TSGs by binding t...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer.
Authors: Sen P, Ganguly P, Ganguly N Abstract Human papillomaviruses (HPVs) are double stranded circular DNA viruses that infect cutaneous and mucosal epithelial cells. Almost 99% of cervical cancer has a HPV infection. The early oncoproteins E6 and E7 are important in this cellular transformation process. Epigenetic mechanisms have long been known to result in decisive alterations in DNA, leading to alterations in DNA-protein interactions, alterations in chromatin structure and compaction and significant alterations in gene expression. The enzymes responsible for these epigenetic modifications are DNA methyl trans...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers.
Authors: Pan Y, Mao Y, Jin R, Jiang L Abstract The Notch signaling pathway is one of the main signaling pathways that mediates direct contact between cells, and is essential for normal development. It regulates various cellular processes, including cell proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. It additionally serves an important function in tumor progression. Non-coding RNAs mainly include small microRNAs, long non-coding RNAs and circular RNAs. At present, a large body of literature supports the biological significance of non-coding RNAs in tumor progression. It is also becoming ...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Function of insulin-like growth factor 1 receptor in cancer resistance to chemotherapy.
Authors: Yuan J, Yin Z, Tao K, Wang G, Gao J Abstract Drug resistance is a primary cause of chemotherapeutic failure; however, how this resistance develops is complex. A comprehensive understanding of chemotherapeutic resistance mechanisms may aid in identifying more effective drugs and improve the survival rates of patients with cancer. Insulin-like growth factor 1 receptor (IGF1R), a member of the insulin receptor family, has been extensively assessed for biological activity, and its putative contribution to tumor cell development and progression. Furthermore, researchers have attended to drugs that target IGF1R ...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Radiographic findings of hemolymphangioma in four patients: A case report.
Authors: Mao CP, Jin YF, Yang QX, Zhang QJ, Li XH Abstract Due to the rarity of hemolymphangioma, a limited number of cases of the disease have been reported in the literature thus far. The present case report describes the cases of 4 patients with hemolymphangioma that were diagnosed and treated at the Second Affiliated Hospital of Xi'an Jiaotong University (Xi'an, China). All patients were female, with a mean age of 44.7 years and a mean duration of symptoms prior to diagnosis of 2.7 years. The diagnosis of hemolymphangioma was determined by postoperative histopathology in all patients. A total of 2 patients were...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Nuclear expression of claudin-3 in human colorectal adenocarcinoma cell lines and tissues.
Authors: Tokuhara Y, Morinishi T, Matsunaga T, Sakai M, Sakai T, Ohsaki H, Kadota K, Kushida Y, Haba R, Hirakawa E Abstract Claudins are members of a large family of transmembrane proteins, which are essential for the formation of tight junctions and have a significant effect on the biological behavior of tumor progression. Previous studies have demonstrated that several claudins show aberrant expression patterns in numerous types of cancer. The present study investigated the expression and localization of claudin-3 and claudin-7 in human colorectal adenocarcinoma cell lines and tissues. The protein expression leve...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling.
Authors: Wang F, Wang W, Li J, Zhang J, Wang X, Wang M Abstract Gefitinib is a targeted anticancer drug that was developed as an effective clinical therapy for lung cancer. Numerous patients develop gefitinib resistance in response to treatment. Sulforaphane (SFN) is present in cruciferous vegetables, and has been demonstrated to inhibit the malignant growth of various types of cancer cells. To investigate the role of SFN in gefitinib resistance, a gefitinib-tolerant PC9 (PC9GT) cell model was established by continually exposing PC9 cells to gefitinib. Cell viability was measured using a cell proliferation assay. C...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Spontaneous remission of acute lymphoblastic leukemia: A case report.
Authors: Höres T, Wendelin K, Schaefer-Eckart K Abstract Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summarized from earlier case reports and incidences of SR in ALL, to identify common patterns. Furthermore, the phenomenon of SR is compared with another disease variant of ALL, termed prodromal or preceding-ALL (pre-ALL). SR and the aleukemic phas...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

CDKN1A-interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma.
Authors: Zhou X, Liu Q, Wada Y, Liao L, Liu J Abstract CDKN1A-interacting zinc finger protein 1 (CIZ1), a nuclear protein that participates in DNA replication, is involved in the pathogenesis of several types of cancer. However, the role of CIZ1 in lung squamous cell carcinoma (LSCC) is not fully understood. In the present study, the expression of CIZ1 in tissue microarrays and surgical samples of human LSCCs was examined. CIZ1 expression was found to be significantly increased in LSCC tissues compared with adjacent tissues or normal controls, whereas expression of a CIZ1-interacting protein, p21Cip1/Waf1, was decr...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Ten-eleven translocation 1 dysfunction reduces 5-hydroxymethylcytosine expression levels in gastric cancer cells.
Authors: Wang KC, Kang CH, Tsai CY, Chou NH, Tu YT, Li GC, Lam HC, Liu SI, Chang PM, Lin YH, Tsai KW Abstract A sixth base, 5-hydroxymethylcytosine (5hmC), is formed by the oxidation of 5-methylcytosine (5mC) via the catalysis of the ten-eleven translocation (TET) protein family in cells. Expression levels of 5hmC are frequently depleted during carcinogenesis. However, the detailed mechanisms underlying the depletion of 5hmC expression in gastric cancer cells remains unclear, and further research is required. The present study examined the expression levels of 5mC and 5hmC and the expression levels of TET1 and TET2...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Orbital alveolar soft part sarcoma: A report of 8 cases and review of the literature.
Authors: Hei Y, Kang L, Yang X, Wang Y, Lu X, Li Y, Zhang W, Xiao L Abstract Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm. The incidence of orbital involvement is the highest in ASPS arising in the head and neck region. However, limited information is available regarding its clinical characteristics. The present study presents the clinical manifestations, imaging findings, pathological features, treatment strategies and prognosis records of 8 cases of orbital ASPS over the last 15 years in a single hospital, along with a review of the literature. Included were 3 male and 5 female patients, with ...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Combination of the neutrophil to lymphocyte ratio and the platelet to lymphocyte ratio as a useful predictor for recurrence following radiofrequency ablation of hepatocellular carcinoma.
Authors: Chen K, Zhan MX, Hu BS, Li Y, He X, Fu SR, Xin YJ, Lu LG Abstract The aim of the present study was to investigate the prognostic potential of a novel inflammation-based system, the combination of the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) (CNP), for predicting the survival time of patients with hepatocellular carcinoma (HCC) who had received radiofrequency ablation (RFA). A total of 287 HCC patients treated with RFA were enrolled in the study. Patients with an elevated NLR (>2.58) and an elevated PLR (>131.78) were allocated a score of 2, and patients exhibiti...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

14-3-3 ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells. Oncol Lett. 2018 Jan;15(1):338-346 Authors: Lu K, Rui G, Liu F, Yang L, Deng X, Shi S, Li Q Abstract The 14-3-3 protein family may regulates protein interaction, transportation and cellular localization. The regulatory role of 14-3-3ε is influenced by its altered localization. In the present study, human osteosarcoma MG-63 cells were treated with curcumin to induce apoptosis. Subsequently, the altered expression and localization of 14-3-3&epsilo...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Identification of key miRNA-gene pairs in chronic lymphocytic leukemia through integrated analysis of mRNA and miRNA microarray.
Authors: Li J, Qin Y, Zhang H Abstract The aim of the present study was to explore the miRNA-Gene regulatory mechanism in chronic lymphocytic leukemia (CLL), and identify new targets for the therapy of CLL. The miRNA expression dataset GSE62137 and mRNA expression dataset GSE22529 were downloaded from National Center of Biotechnology Information Gene Expression Omnibus database. In CLL samples compared with normal B cell samples, differentially expressed miRNAs (DEMs) were identified via the GEO2R instrument of GEO and differentially expressed genes (DEGs) were obtained via the limma package of R. Functional enrich...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Correlation of telomere length to malignancy potential in non-melanoma skin cancers.
Authors: Yamada-Hishida H, Nobeyama Y, Nakagawa H Abstract Telomeres are associated with cell fate and aging through their role in the cellular response to stress and growth stimulation resulting from previous cell divisions and DNA damage. Telomere shortening has been observed in most human cancers, and is known to be a feature of malignancy. The aim of this study is to clarify whether telomere length is related to the malignant potential of non-melanoma skin cancers. Telomere length was analyzed using tissue quantitative fluorescence in situ hybridization in 36 non-melanoma skin cancers including basal cell carci...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1.
Authors: Li M, Wang J, Mo B, Zeng J, Yao D, Chen F, Jiang M, Rao L, Du Y Abstract Cell division cycle 42 (Cdc42) is a critical regulator, which functions in cancer metastasis. Numerous previous studies have demonstrated that vav guanine nucleotide exchange factor 1 (Vav1) is ectopically expressed in numerous types of human malignancies and have suggested that Vav1 may efficiently promote the formation of invadopodia and matrix degradation by regulating the activation of Cdc42. Total alkaloids of Corydalis saxicola bunting (TAOCSB), a type of alkaloid compound extracted from the root of C. saxicola bunting, has been...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of ADAM9 in oral squamous cell carcinoma.
Authors: Tanasubsinn P, Aung WPP, Pata S, Laopajon W, Makeudom A, Sastraruji T, Kasinrerk W, Krisanaprakornkit S Abstract Overexpression of a disintegrin and metalloproteinase 9 (ADAM9) has been shown in various types of cancer. Some studies have reported inconclusive findings regarding chromosomal aberrations in the ADAM9-containing region and ADAM9 expression in oral cancer. Therefore, in this study, ADAM9 protein expression was determined and compared between oral squamous cell carcinoma (OSCC) and normal oral tissues, and between oral cancer cell lines and human oral keratinocytes (HOKs). In total, 34 OSCC and ...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Activation of PGE2/EP2 and PGE2/EP4 signaling pathways positively regulate the level of PD-1 in infiltrating CD8+ T cells in patients with lung cancer.
Authors: Wang J, Zhang L, Kang D, Yang D, Tang Y Abstract The present study aimed to identify the level of programmed death-1 (PD-1) expression in infiltrating cluster of differentiation (CD)4+ and CD8+ T cells isolated from lung cancer tissues, and investigated whether the level of PD-1 expression may be directly regulated by lung cancer cells via prostaglandin E2 (PGE2)-associated signaling pathways in patients with lung cancer. A total of 75 patients with lung cancer were enrolled in the present study. The percentage of infiltrating CD4+ and CD8+ T cells was determined by flow cytometry. ELISA was performed to e...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of HuR downregulation on anaplastic thyroid cancer cells.
Authors: Allegri L, Mio C, Russo D, Filetti S, Baldan F Abstract Anaplastic thyroid cancer (ATC) constitutes one of the most aggressive types of human solid cancer, and is characterized by the absence of thyroid differentiation features and a marked degree of invasiveness. We have previously demonstrated that the RNA-binding protein Hu antigen R (HuR) is overexpressed in thyroid carcinoma; thus, the biological role of this RNA-binding protein was investigated in the present study using the ATC cell lines SW1736 and 8505C. In both cell lines, HuR protein levels were higher compared with in the non-tumorigenic thyroi...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effective treatment of a patient with stage IV ovarian cancer: A case report.
Authors: Huang Z, Yan H, Chavan D, Yuan Z, Yang X, Zhang Y, Song K, Kong B Abstract The present case report describes a patient with stage IV ovarian cancer who survived for 9 years without achieving a complete remission since the first relapse. The patient's long-term survival may be ascribed to the slow growth of the cancer cells, limited metastasis and favorable responses to the treatments received. The patient manifested initially with malignant pleural effusion and was not able to tolerate surgical treatment. However, the disease was well-controlled using various treatments, including neoadjuvant chemotherapy,...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Anticancer effect of S-allyl-L-cysteine via induction of apoptosis in human bladder cancer cells.
Authors: Ho JN, Kang M, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS Abstract To examine the anticancer effects of S-allyl-L-cysteine (SAC) in human bladder cancer cells and to identify possible molecular mechanisms, bladder cancer cell lines (HTB5, HTB9, JON, UMUC14, T24, and cisplatin resistant-T24R2) were incubated with SAC, and cell proliferation was measured using the Cell Counting Kit-8 assay and clonogenic assay. Cell cycle and apoptosis were evaluated by flow cytometry. Expression levels of apoptosis- and cell cycle-associated proteins were analyzed by western blotting. Proliferation and colony formation in bladd...
Source: Oncology Letters - December 31, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-502-mediated histone methyltransferase SET8 expression is associated with clear cell renal cell carcinoma risk.
Authors: Zhang S, Guo Z, Xu J, Wang J, Zhang J, Cui L, Zhang H, Liu Y, Bai Y Abstract Genetic variants may affect the interactions between microRNAs (miRNAs/miRs) and their target genes by modulating their binding affinity or by creating, or destroying a miRNA-binding site. SET domain containing (lysine methyltransferase) 8 (SET8) is the sole lysine methyltransferase that catalyzes the monomethylation of histone H4 lysine 20, and is associated with tumor growth, invasion and metastasis. In the present study, the rs16917496 polymorphism within the miR-502 binding site of the SET8 mRNA 3' untranslated region (3'UTR) ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Radiofrequency heat-enhanced direct intratumoral chemotherapy for prostate cancer.
In conclusion, the results of the present study suggested that RFH is able to increase the therapeutic efficiency of docetaxel in prostate cancer, and this study serves as a foundation for the future development of an interventional molecular image-guided local treatment strategy for prostate cancer that integrates RF technology, interventional oncology and direct intratumoral chemotherapy, as a replacement for systemic chemotherapy. PMID: 29250164 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Evaluating the associations between human circadian rhythms and dysregulated genes in liver cancer cells.
Authors: Polo A, Singh S, Crispo A, Russo M, Giudice A, Montella M, Colonna G, Costantini S Abstract Network analysis is a useful approach in cancer biology as it provides information regarding the genes and proteins. In our previous study, a network analysis was performed on dysregulated genes in HepG2 cells, a hepatoblastoma cell line that lacks the viral infection, compared with normal hepatocytes, identifying the presence of 26 HUB genes. The present study aimed to identify whether these previously identified HUB genes participate in the network that controls the human circadian rhythms. The results of the pres...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Reactivity of thyroid papillary carcinoma cells to thyroid stimulating hormone-dominated endocrine therapy.
This study investigated the effect of thyroid stimulating hormone (TSH) on the proliferation of papillary thyroid carcinoma (PTC) cells and the therapeutic effect of levothyroxine sodium (TH). PTC cells (TPC-1) were cultured using 0.1, 1.0 and 10 U/l TSH and 10-2, 10-4 and 10-6 mol/l TH. After the appropriate concentration was screened, TPC-1 cells were further divided into control group, TSH group, TH group and TSH+TH group. The cell proliferation was detected via methyl thiazolyl tetrazolium (MTT) method, TPC-1 cell cycle was detected via flow cytometer, and the mRNA and protein expression of cyclin D1 were detected via ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Associations between abnormal vitamin D metabolism pathway function and non-small cell lung cancer.
Authors: Ge N, Chu XM, Xuan YP, Ren DQ, Wang Y, Ma K, Gao HJ, Jiao WJ Abstract Lung cancer is a type of malignant tumor derived from the respiratory system, which is the leading cause of cancer-associated mortality worldwide, of which ~80% of cases are attributable to non-small cell lung cancer (NSCLC). A previous study demonstrated that 1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3), derived from the vitamin D metabolic pathway contributes an antitumor effect. Aberrant expression of the essential enzyme encoding genes, Cytochrome P450 Family 27 Subfamily A Member 1 (CYP27A1), Cytochrome P450 Family 27 Subfam...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Anti-angiogenic effect of Livistona chinensis seed extract in vitro and in vivo.
Authors: Cao Z, Zheng L, Zhao J, Zhuang Q, Hong Z, Lin W Abstract The present study aimed to detect the impact of the ethanol extract of the Livistona chinensis seed (EELC) on angiogenesis in human umbilical vein endothelial cells (HUVECs). A chorioallantoic membrane (CAM) assay was used to detect the anti-angiogenic activity of EELC in vivo. In vitro, the effect of EELC on the proliferation, migration and angiogenesis of HUVECs was determined by an MTT assay, a wound healing assay and a tube formation assay, respectively. The vascular endothelial growth factor (VEGF)-A and VEGF receptor (VEGFR)-2 protein and mRNA ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Therapeutic strategies against cancer stem cells in human colorectal cancer.
In conclusion, the discovery of CSCs has resulted in the definition of novel therapeutic targets and the development of novel experimental therapies for CRC. However, further investigations are required in order to apply these novel drugs in human CRC. PMID: 29250169 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Liver X receptors as potential targets for cancer therapeutics.
Authors: Ju X, Huang P, Chen M, Wang Q Abstract Liver X receptors (LXRs) are important members of the nuclear receptor family that were originally determined to function in cholesterol transport and the regulation of immune responses. Synthetic LXR ligands have been developed to treat various diseases including diabetes, Alzheimer's disease and atherosclerosis. Previous studies have suggested that LXRs are also involved in numerous types of cancer and are therefore potential targets for cancer therapeutics. The present review summarizes LXR ligands and their mechanisms of action, the effects of LXRs in different ty...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Computational identification of microRNAs and their targets in liver cirrhosis.
Authors: Du H, Yu H, Yang Y, Song Y, Wang F, Li S, Jiang Y Abstract Previous studies have revealed that the deregulation of circulating miRNAs is associated with liver cirrhosis. The present study aimed to identify reliable candidate biomarkers to improve the early detection of liver cirrhosis. An integrated analysis of expression profiles of microRNAs (miRNAs/miRs) and mRNAs in liver cirrhosis tissues from the GEO database was performed. Next, the regulatory targets of the differentially expressed miRNAs in liver cirrhosis tissues were predicted. In addition, a regulatory network of miRNA-target genes was construc...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma.
Authors: Zhao J, Liu N, Hao X, Que L, Liu J, Tang X Abstract The present study aimed to observe the effect of the biological functions of integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) Tca8113 cells and, combined with hyperthermia, several experimental methods were used to detect their biological behavior in vitro. On the basis of in vitro experiments, Tca8113 cells were transplanted into nude mice models, and ILK-shRNA-lentivirus was injected into the nude mice t...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Hypoxia-inducible factor 1 mediates intermittent hypoxia-induced migration of human breast cancer MDA-MB-231 cells.
Authors: Liu L, Liu W, Wang L, Zhu T, Zhong J, Xie N Abstract Metastasis is the major cause of triple-negative breast cancer (TNBC)-associated mortality. Hypoxia promotes cancer cell migration and remote metastasis, which occur with hypoxia inducible factor 1α (HIF-1α) stabilization and vimentin upregulation. However, the evolutionary dynamics that link the changes in HIF-1α and vimentin levels under hypoxic conditions are not well understood. In the present study, the effects of intermittent hypoxia (IH), continuous hypoxia (CH) and normoxia on the migration and proliferation of human TNBC MDA-MB...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Increased expression of tumor protein D54 is associated with clinical progression and poor prognosis in patients with prostate cancer.
Authors: Ren L, Chen J, Zhang X Abstract Tumor protein D54 (TPD54) has been reported to be involved in the prognosis of several cancers. However, the involvement of TPD54 in prostate cancer (PCa) is yet to be elucidated. In the present study, 117 patients with PCa were enrolled. The mRNA and protein levels of TPD54 in PCa tissues and adjacent normal prostate tissues were analyzed by quantitative polymerase chain reaction and western blotting. TPD54 expression was also determined by immunohistochemistry (IHC) in paraffin-embedded PCa tissues. The association between TPD54 expression and clinicopathological features ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

ATP7B expression in human glioblastoma is related to temozolomide resistance.
Authors: Moinuddin FM, Hirano H, Shinsato Y, Higa N, Arita K, Furukawa T Abstract Glioblastoma multiforme (GBM) is one of the most aggressive types of brain malignancy, with resistance to chemotherapy being a primary treatment obstacle. ATPase copper transporting β (ATP7B) is involved in multidrug resistance; however, its expression in GBM remains to be evaluated. In the present study, GBM specimens from 79 patients who underwent gross total tumor removal followed by concomitant temozolomide (TMZ) chemotherapy and radiotherapy were assessed immunohistochemically. The association between the overall survival ti...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Leucine-rich repeat-containing G protein-coupled receptor 5 and CD133 expression is associated with tumor progression and resistance to preoperative chemoradiotherapy in low rectal cancer.
Authors: Harada Y, Kazama S, Morikawa T, Murono K, Yasuda K, Otani K, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Nozawa H, Yamaguchi H, Ishihara S, Watanabe T Abstract Preoperative chemoradiotherapy has been performed as a standard therapy for advanced low rectal cancer. Cancer stem cells (CSCs) have been reported to contribute to resistance to treatment and patient prognosis. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and cluster of differentiation (CD133) are putative markers for CSCs. However, their prognostic ability remains unknown, and evaluation of a single marker can be ins...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
Authors: Ye Y, Zhuang J, Wang G, He S, Ni J, Xia W Abstract Thyroid cancer is the most common tumour of the endocrine system, and its incidence rate has markedly increased over the past several decades. Aberrantly expressed microRNAs (miRNAs) are reportedly involved in the formation and progression of papillary thyroid carcinoma (PTC) by regulating their target genes. Thus, miRNAs may be potential molecular biomarkers for the prediction and prognosis of PTC, and also as novel therapeutic targets for patients with PTC. miR-139 has recently been reported to be aberrantly expressed in several types of cancer. However,...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Toll-like receptor-9 in hypoxic nasopharyngeal carcinoma cells and its correlation with cell proliferation and apoptosis.
In conclusion, TLR-9 was highly expressed in hypoxic nasopharyngeal carcinoma cells regulating cell proliferation and apoptosis, which may be an important mechanism of tumorigenesis and a potential target for intervention therapy. PMID: 29250178 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

No association between triple-negative breast cancer and prognosis of patients receiving breast-conserving treatment.
Authors: Mu L, Liu Y, Xiao M, Liu W, Liu M, Wang X Abstract The role of triple-negative breast cancer (TNBC) in breast-conserving treatment is controversial. The present study aimed at evaluating the prognosis of patients with TNBC following breast-conserving treatment (BCT) within 5 years. The present study investigated a cohort of 757 patients with early stage breast cancer, diagnosed and treated with BCT between January 2002 and March 2010 at Tianjin Medical University Cancer Institute and Hospital. The patients were divided into three groups according to receptor expression: Estrogen receptor (ER) or progestero...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Bioinformatics analysis of gene expression profiles to identify causal genes in luminal B2 breast cancer.
In conclusion, the DEGs identified in the present study, including NTRK2, FN1 and EGFR, may serve pivotal roles in the tumorigenesis of LB2BC by affecting the 'focal adhesion', 'pathways in cancer' and 'ECM-receptor interaction' KEGG pathways. PMID: 29250180 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA-132 expression.
Authors: Zhou WJ, Yang HL, Chang KK, Meng Y, Wang MY, Yuan MM, Li MQ, Xie F Abstract Thymic stromal lymphopoietin (TSLP), produced by cervical cancer (CC) cells, promotes angiogenesis, and the recruitment and functional regulation of eosinophils. It has been reported that microRNA (miR)-132 is aberrantly decreased in CC tissues. However, the function and mechanism of TSLP on the biological behaviors of CC cells is largely unknown. The aim of the present study was to investigate the effect of TSLP on the expression of miR-132 and the proliferation and invasion in vitro of CC cell lines, namely, HeLa and SiHa cells. ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Peripheral lung adenocarcinomas harboring epithelial growth factor receptor mutations with microRNA-135b overexpression are more likely to invade visceral pleura.
Authors: Le H, Wang X, Zha Y, Wang J, Zhu W, Ye Z, Liu X, Ma H, Zhang Y Abstract Lung adenocarcinoma, characterized by its early and aggressive local invasion and high metastatic potential, is the most frequently observed histological type of non-small-cell lung cancer (NSCLC). Visceral pleural invasion (VPI) caused by peripheral lung adenocarcinomas is closely associated with the poor prognosis of patients with NSCLC. The association between VPI and some clinicopathological characteristics has been observed in the past few decades. However, the molecular mechanism of VPI in lung adenocarcinomas is unknown. In the ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Ampelopsin-induced reactive oxygen species enhance the apoptosis of colon cancer cells by activating endoplasmic reticulum stress-mediated AMPK/MAPK/XAF1 signaling.
Authors: Park GB, Jeong JY, Kim D Abstract Ampelopsin (Amp) is bioactive natural product and exerts anti-cancer effects against several cancer types. The present study investigated the anti-colon cancer activity of Amp and explored its mechanism of action. The treatment of colon cancer cells with Amp resulted in the dose- and time-dependent induction of apoptosis via the activation of endoplasmic reticulum (ER) stress, 5' adenosine monophosphate-activated protein kinase (AMPK), and c-Jun N-terminal protein kinase (JNK)/p38 mitogen-activated protein kinases (MAPKs). Salubrinal, an ER stress inhibitor, prevented the ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Imbalance in circulatory iNKT, Th17 and T regulatory cell frequencies in patients with B-cell non-Hodgkin's lymphoma.
Authors: Hus I, Bojarska-Junak A, Kamińska M, Dobrzyńska-Rutkowska A, Szatan K, Szymczyk A, Kukiełka-Budny B, Szczepanek D, Roliński J Abstract T cells are important in B-cell non-Hodgkin's lymphoma immunity, however the function of T cell subsets, including natural killer (iNKT), T helper (Th)17, and T regulatory cells remains to be elucidated. The present study analyzed the frequencies of iNKT, Th17 and T regulatory cells in the peripheral blood of 41 patients with B-cell non-Hodgkin lymphoma at diagnosis, then during and following immunochemotherapy R-CHOP/R-CVP. At lymphoma diagnosis, iNKT and Th17 frequenc...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Inhibition of Gli1-mediated prostate cancer cell proliferation by inhibiting the mTOR/S6K1 signaling pathway.
Authors: Yang H, Hu L, Liu Z, Qin Y, Li R, Zhang G, Zhao B, Bi C, Lei Y, Bai Y Abstract Ectopic activation of the canonical Hedgehog signaling pathway is involved in the development and progression of prostate cancer, which is one of the leading causes of cancer-associated mortality in males worldwide. However, the role of the non-canonical Hedgehog signaling pathway in prostate cancer remains generally unexplored. In the present study, it was identified that Gli (glioma-associated oncogene)1 and Gli2 were highly expressed at the protein level in the androgen-independent prostate cancer cell lines PC3 and DU145, bu...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of long non-coding RNA HOTAIR sensitizes hepatocellular carcinoma cell to cisplatin by suppressing the STAT3/ABCB1 signaling pathway.
Authors: Zhou JJ, Cheng D, He XY, Meng Z, Ye HL, Chen RF Abstract Long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been demonstrated to exhibit oncogenic activity in several types of cancer, including hepatocellular carcinoma (HCC). However, the association between HOTAIR and HCC multidrug resistance remains uncertain. The present study aimed to investigate the role of HOTAIR in HCC chemoresistance; it was found that knockdown of HOTAIR expression in HCC Huh7 cells resulted in decreased cell proliferation and increased chemosensitivity to cisplatin. Furthermore, expression levels of ATP binding cassett...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of Rhotekin 2 expression suppresses proliferation and induces apoptosis in colon cancer cells.
Authors: Pang X, Li R, Shi D, Pan X, Ma C, Zhang G, Mu C, Chen W Abstract Colon cancer is one of the most common malignant tumors in the human body, ranking second as a gastrointestinal tumor. It has a high incidence in Europe, America and China and more than 1 million new cases of colon cancer are reported worldwide each year. The incidence of colon cancer in China has increased from 12/0.1 million in the early 1970s to 56/0.1 million at present with an annual growth rate of 4.2%, which far exceeds the international level (2%). Rhotekin (RTKN) 2, a Rho-guanosine triphosphatase (GTPase) effector, has been reported ...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia.
Authors: Mei Y, Li Z, Zhang Y, Zhang W, Hu H, Zhang P, Wu M, Huang D Abstract The prognostic significance of microRNA (miR)-210 and the caspase 8-associated protein 2 (CASP8AP2) gene in children with acute lymphoblastic leukemia (ALL) has been validated and CASP8AP2 has been demonstrated as a target of miR-210. In the present study, the reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to determine miR-210 and CASP8AP2 expression in 91 children with ALL. Associations between gene expression levels and the prognostic value of combined detection of the two indicators were analyzed. Resul...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

DDR2 facilitates papillary thyroid carcinoma epithelial mesenchymal transition by activating ERK2/Snail1 pathway.
In conclusion, these results indicate that DDR2 is upregulated in PTC tissues with local metastasis. Overexpression of DDR2 induced EMT in PTC cells by activating ERK2 and stabilizing Snail1, making it a promising therapeutic target for reducing PTC local or distant metastasis. PMID: 29250189 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Role of exosomes in hepatocellular carcinoma cell mobility alteration.
Authors: Wang S, Chen G, Lin X, Xing X, Cai Z, Liu X, Liu J Abstract Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types of cancer worldwide, with exosomes implicated to play a crucial role in its regulation; however, the possible function of exosomes in modulating the motile ability of tumor cells and key molecules in HCC remain largely unknown. To investigate the regulatory effect of exosomes on...
Source: Oncology Letters - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research