USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner
Oncol Lett. 2021 May;21(5):421. doi: 10.3892/ol.2021.12682. Epub 2021 Mar 29.ABSTRACTUbiquitin-specific peptidase (USP)18 belongs to the USP family, and is involved in cleaving and removing ubiquitin or ubiquitin-like molecules from their target molecules. Recently, increasing evidence has suggested that USP18 is constitutively expressed in different types of human tumors, and ectopic expression or downregulation of USP18 expression may contribute to tumorigenesis. However, the role of USP18 in uterine cervical cancer (UCC) remains unclear. Thus, the present study aimed to investigate USP18 expression in a human tissue mic...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Aonan Pan Yue Li Jian Guan Pengxia Zhang Chunbin Zhang Yupeng Han Tao Zhang Yao Cheng Luo Sun Shizhen Lu Jinru Weng Qiaosheng Ren Shengjie Fan Weiqun Wang Jingtao Wang Source Type: research

Detection of circulating tumor cells: Advances and critical concerns
Oncol Lett. 2021 May;21(5):422. doi: 10.3892/ol.2021.12683. Epub 2021 Mar 29.ABSTRACTMetastasis is the main cause of cancer-related death and the major challenge in cancer treatment. Cancer cells in circulation are termed circulating tumor cells (CTCs). Primary tumor metastasis is likely due to CTCs released into the bloodstream. These CTCs extravasate and form fatal metastases in different organs. Analyses of CTCs are clarifying the biological understanding of metastatic cancers. These data are also helpful to monitor disease progression and to inform the development of personalized cancer treatment-based liquid biopsy. H...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Xiuxiu Hu Xiaojuan Zang Yanguan Lv Source Type: research

Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy
Oncol Lett. 2021 May;21(5):423. doi: 10.3892/ol.2021.12684. Epub 2021 Mar 29.ABSTRACTCervical cancer remains a major health threat. Urokinase serves as a marker of metastatic tumors. The present study aimed to determine whether the expression levels of urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), before and during the course of radiotherapy, serve as prognostic markers for patients with cervical cancer. Cervical tumor tissue biopsies were collected from 72 patients before radiotherapy and after the completion of external beam radiotherapy (EBRT) before intracavitary brachythera...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Danupon Nantajit Piyawan Chailapakul Sarinya Bawornpatarapakorn Sasikarn Chamchod Kanyanee Laebua Source Type: research

Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer
In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer.PMID:33850565 | PMC:PMC8025117 | DOI:10.3892/ol.2021.12685 (Source: Oncology Letters)
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Dan Liu Ya Gao Lingling Li He Chen Lu Bai Yanli Qu Baosen Zhou Ying Yan Yuxia Zhao Source Type: research

Polysaccharides from sporoderm-removed spores of < em > Ganoderma lucidum < /em > induce apoptosis in human gastric cancer cells via disruption of autophagic flux
Oncol Lett. 2021 May;21(5):425. doi: 10.3892/ol.2021.12686. Epub 2021 Mar 29.ABSTRACTThe sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of G. lucidum (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer ce...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Jiayi Zhong Liu Fang Rong Chen Jing Xu Dandan Guo Chengjie Guo Cuiling Guo Jiajun Chen Chaojie Chen Xingya Wang Source Type: research

Hydroxyl safflower yellow B combined with doxorubicin inhibits the proliferation of human breast cancer MCF-7 cells
Oncol Lett. 2021 May;21(5):426. doi: 10.3892/ol.2021.12687. Epub 2021 Mar 29.ABSTRACTDoxorubicin (DOX) is currently the preferred chemotherapeutic agent for breast cancer, and hydroxyl safflower yellow B (HSYB) has a tumor growth-inhibiting activity. The present study aimed to investigate the effects of HSYB combined with DOX on the proliferation of human breast cancer MCF-7 cells and explore the underlying mechanism. MTT and cell colony formation assays revealed that the proliferation rate of MCF-7 cells was signifiscantly decreased after HSYB and DOX treatment. Combined HSYB and DOX treatment significantly decreased the ...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Kehao Lin Ze Qin Chuanjun Qu Xiaoyu Chen Qingling Jiang Minjing Li Qiusheng Zheng Defang Li Source Type: research

miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1
Oncol Lett. 2021 May;21(5):427. doi: 10.3892/ol.2021.12688. Epub 2021 Mar 30.ABSTRACTEndometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC. Whether miR-20a-5p could inhibit EC progression by targeting janus kinase 1 (Jak1) was subsequently investigated. To do so, human EC tissues and paracancerous tissues were collected from 47 p...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Ying He Hui Ma Jing Wang Yanhua Kang Qianlong Xue Source Type: research

USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner
Oncol Lett. 2021 May;21(5):421. doi: 10.3892/ol.2021.12682. Epub 2021 Mar 29.ABSTRACTUbiquitin-specific peptidase (USP)18 belongs to the USP family, and is involved in cleaving and removing ubiquitin or ubiquitin-like molecules from their target molecules. Recently, increasing evidence has suggested that USP18 is constitutively expressed in different types of human tumors, and ectopic expression or downregulation of USP18 expression may contribute to tumorigenesis. However, the role of USP18 in uterine cervical cancer (UCC) remains unclear. Thus, the present study aimed to investigate USP18 expression in a human tissue mic...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Aonan Pan Yue Li Jian Guan Pengxia Zhang Chunbin Zhang Yupeng Han Tao Zhang Yao Cheng Luo Sun Shizhen Lu Jinru Weng Qiaosheng Ren Shengjie Fan Weiqun Wang Jingtao Wang Source Type: research

Detection of circulating tumor cells: Advances and critical concerns
Oncol Lett. 2021 May;21(5):422. doi: 10.3892/ol.2021.12683. Epub 2021 Mar 29.ABSTRACTMetastasis is the main cause of cancer-related death and the major challenge in cancer treatment. Cancer cells in circulation are termed circulating tumor cells (CTCs). Primary tumor metastasis is likely due to CTCs released into the bloodstream. These CTCs extravasate and form fatal metastases in different organs. Analyses of CTCs are clarifying the biological understanding of metastatic cancers. These data are also helpful to monitor disease progression and to inform the development of personalized cancer treatment-based liquid biopsy. H...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Xiuxiu Hu Xiaojuan Zang Yanguan Lv Source Type: research

Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy
Oncol Lett. 2021 May;21(5):423. doi: 10.3892/ol.2021.12684. Epub 2021 Mar 29.ABSTRACTCervical cancer remains a major health threat. Urokinase serves as a marker of metastatic tumors. The present study aimed to determine whether the expression levels of urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), before and during the course of radiotherapy, serve as prognostic markers for patients with cervical cancer. Cervical tumor tissue biopsies were collected from 72 patients before radiotherapy and after the completion of external beam radiotherapy (EBRT) before intracavitary brachythera...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Danupon Nantajit Piyawan Chailapakul Sarinya Bawornpatarapakorn Sasikarn Chamchod Kanyanee Laebua Source Type: research

Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer
In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer.PMID:33850565 | PMC:PMC8025117 | DOI:10.3892/ol.2021.12685 (Source: Oncology Letters)
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Dan Liu Ya Gao Lingling Li He Chen Lu Bai Yanli Qu Baosen Zhou Ying Yan Yuxia Zhao Source Type: research

Polysaccharides from sporoderm-removed spores of < em > Ganoderma lucidum < /em > induce apoptosis in human gastric cancer cells via disruption of autophagic flux
Oncol Lett. 2021 May;21(5):425. doi: 10.3892/ol.2021.12686. Epub 2021 Mar 29.ABSTRACTThe sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of G. lucidum (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer ce...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Jiayi Zhong Liu Fang Rong Chen Jing Xu Dandan Guo Chengjie Guo Cuiling Guo Jiajun Chen Chaojie Chen Xingya Wang Source Type: research

Hydroxyl safflower yellow B combined with doxorubicin inhibits the proliferation of human breast cancer MCF-7 cells
Oncol Lett. 2021 May;21(5):426. doi: 10.3892/ol.2021.12687. Epub 2021 Mar 29.ABSTRACTDoxorubicin (DOX) is currently the preferred chemotherapeutic agent for breast cancer, and hydroxyl safflower yellow B (HSYB) has a tumor growth-inhibiting activity. The present study aimed to investigate the effects of HSYB combined with DOX on the proliferation of human breast cancer MCF-7 cells and explore the underlying mechanism. MTT and cell colony formation assays revealed that the proliferation rate of MCF-7 cells was signifiscantly decreased after HSYB and DOX treatment. Combined HSYB and DOX treatment significantly decreased the ...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Kehao Lin Ze Qin Chuanjun Qu Xiaoyu Chen Qingling Jiang Minjing Li Qiusheng Zheng Defang Li Source Type: research

miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1
Oncol Lett. 2021 May;21(5):427. doi: 10.3892/ol.2021.12688. Epub 2021 Mar 30.ABSTRACTEndometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC. Whether miR-20a-5p could inhibit EC progression by targeting janus kinase 1 (Jak1) was subsequently investigated. To do so, human EC tissues and paracancerous tissues were collected from 47 p...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Ying He Hui Ma Jing Wang Yanhua Kang Qianlong Xue Source Type: research

USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner
Oncol Lett. 2021 May;21(5):421. doi: 10.3892/ol.2021.12682. Epub 2021 Mar 29.ABSTRACTUbiquitin-specific peptidase (USP)18 belongs to the USP family, and is involved in cleaving and removing ubiquitin or ubiquitin-like molecules from their target molecules. Recently, increasing evidence has suggested that USP18 is constitutively expressed in different types of human tumors, and ectopic expression or downregulation of USP18 expression may contribute to tumorigenesis. However, the role of USP18 in uterine cervical cancer (UCC) remains unclear. Thus, the present study aimed to investigate USP18 expression in a human tissue mic...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Aonan Pan Yue Li Jian Guan Pengxia Zhang Chunbin Zhang Yupeng Han Tao Zhang Yao Cheng Luo Sun Shizhen Lu Jinru Weng Qiaosheng Ren Shengjie Fan Weiqun Wang Jingtao Wang Source Type: research

Detection of circulating tumor cells: Advances and critical concerns
Oncol Lett. 2021 May;21(5):422. doi: 10.3892/ol.2021.12683. Epub 2021 Mar 29.ABSTRACTMetastasis is the main cause of cancer-related death and the major challenge in cancer treatment. Cancer cells in circulation are termed circulating tumor cells (CTCs). Primary tumor metastasis is likely due to CTCs released into the bloodstream. These CTCs extravasate and form fatal metastases in different organs. Analyses of CTCs are clarifying the biological understanding of metastatic cancers. These data are also helpful to monitor disease progression and to inform the development of personalized cancer treatment-based liquid biopsy. H...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Xiuxiu Hu Xiaojuan Zang Yanguan Lv Source Type: research

Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy
Oncol Lett. 2021 May;21(5):423. doi: 10.3892/ol.2021.12684. Epub 2021 Mar 29.ABSTRACTCervical cancer remains a major health threat. Urokinase serves as a marker of metastatic tumors. The present study aimed to determine whether the expression levels of urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), before and during the course of radiotherapy, serve as prognostic markers for patients with cervical cancer. Cervical tumor tissue biopsies were collected from 72 patients before radiotherapy and after the completion of external beam radiotherapy (EBRT) before intracavitary brachythera...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Danupon Nantajit Piyawan Chailapakul Sarinya Bawornpatarapakorn Sasikarn Chamchod Kanyanee Laebua Source Type: research

Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer
In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer.PMID:33850565 | PMC:PMC8025117 | DOI:10.3892/ol.2021.12685 (Source: Oncology Letters)
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Dan Liu Ya Gao Lingling Li He Chen Lu Bai Yanli Qu Baosen Zhou Ying Yan Yuxia Zhao Source Type: research

Polysaccharides from sporoderm-removed spores of < em > Ganoderma lucidum < /em > induce apoptosis in human gastric cancer cells via disruption of autophagic flux
Oncol Lett. 2021 May;21(5):425. doi: 10.3892/ol.2021.12686. Epub 2021 Mar 29.ABSTRACTThe sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of G. lucidum (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer ce...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Jiayi Zhong Liu Fang Rong Chen Jing Xu Dandan Guo Chengjie Guo Cuiling Guo Jiajun Chen Chaojie Chen Xingya Wang Source Type: research

Hydroxyl safflower yellow B combined with doxorubicin inhibits the proliferation of human breast cancer MCF-7 cells
Oncol Lett. 2021 May;21(5):426. doi: 10.3892/ol.2021.12687. Epub 2021 Mar 29.ABSTRACTDoxorubicin (DOX) is currently the preferred chemotherapeutic agent for breast cancer, and hydroxyl safflower yellow B (HSYB) has a tumor growth-inhibiting activity. The present study aimed to investigate the effects of HSYB combined with DOX on the proliferation of human breast cancer MCF-7 cells and explore the underlying mechanism. MTT and cell colony formation assays revealed that the proliferation rate of MCF-7 cells was signifiscantly decreased after HSYB and DOX treatment. Combined HSYB and DOX treatment significantly decreased the ...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Kehao Lin Ze Qin Chuanjun Qu Xiaoyu Chen Qingling Jiang Minjing Li Qiusheng Zheng Defang Li Source Type: research

miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1
Oncol Lett. 2021 May;21(5):427. doi: 10.3892/ol.2021.12688. Epub 2021 Mar 30.ABSTRACTEndometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC. Whether miR-20a-5p could inhibit EC progression by targeting janus kinase 1 (Jak1) was subsequently investigated. To do so, human EC tissues and paracancerous tissues were collected from 47 p...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Ying He Hui Ma Jing Wang Yanhua Kang Qianlong Xue Source Type: research

USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner
Oncol Lett. 2021 May;21(5):421. doi: 10.3892/ol.2021.12682. Epub 2021 Mar 29.ABSTRACTUbiquitin-specific peptidase (USP)18 belongs to the USP family, and is involved in cleaving and removing ubiquitin or ubiquitin-like molecules from their target molecules. Recently, increasing evidence has suggested that USP18 is constitutively expressed in different types of human tumors, and ectopic expression or downregulation of USP18 expression may contribute to tumorigenesis. However, the role of USP18 in uterine cervical cancer (UCC) remains unclear. Thus, the present study aimed to investigate USP18 expression in a human tissue mic...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Aonan Pan Yue Li Jian Guan Pengxia Zhang Chunbin Zhang Yupeng Han Tao Zhang Yao Cheng Luo Sun Shizhen Lu Jinru Weng Qiaosheng Ren Shengjie Fan Weiqun Wang Jingtao Wang Source Type: research

Detection of circulating tumor cells: Advances and critical concerns
Oncol Lett. 2021 May;21(5):422. doi: 10.3892/ol.2021.12683. Epub 2021 Mar 29.ABSTRACTMetastasis is the main cause of cancer-related death and the major challenge in cancer treatment. Cancer cells in circulation are termed circulating tumor cells (CTCs). Primary tumor metastasis is likely due to CTCs released into the bloodstream. These CTCs extravasate and form fatal metastases in different organs. Analyses of CTCs are clarifying the biological understanding of metastatic cancers. These data are also helpful to monitor disease progression and to inform the development of personalized cancer treatment-based liquid biopsy. H...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Xiuxiu Hu Xiaojuan Zang Yanguan Lv Source Type: research

Prognostic significance of uPA and uPAR expression in patients with cervical cancer undergoing radiotherapy
Oncol Lett. 2021 May;21(5):423. doi: 10.3892/ol.2021.12684. Epub 2021 Mar 29.ABSTRACTCervical cancer remains a major health threat. Urokinase serves as a marker of metastatic tumors. The present study aimed to determine whether the expression levels of urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), before and during the course of radiotherapy, serve as prognostic markers for patients with cervical cancer. Cervical tumor tissue biopsies were collected from 72 patients before radiotherapy and after the completion of external beam radiotherapy (EBRT) before intracavitary brachythera...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Danupon Nantajit Piyawan Chailapakul Sarinya Bawornpatarapakorn Sasikarn Chamchod Kanyanee Laebua Source Type: research

Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer
In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer.PMID:33850565 | PMC:PMC8025117 | DOI:10.3892/ol.2021.12685 (Source: Oncology Letters)
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Dan Liu Ya Gao Lingling Li He Chen Lu Bai Yanli Qu Baosen Zhou Ying Yan Yuxia Zhao Source Type: research

Polysaccharides from sporoderm-removed spores of < em > Ganoderma lucidum < /em > induce apoptosis in human gastric cancer cells via disruption of autophagic flux
Oncol Lett. 2021 May;21(5):425. doi: 10.3892/ol.2021.12686. Epub 2021 Mar 29.ABSTRACTThe sporoderm-broken spores of Ganoderma lucidum (G. lucidum) polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of G. lucidum (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer ce...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Jiayi Zhong Liu Fang Rong Chen Jing Xu Dandan Guo Chengjie Guo Cuiling Guo Jiajun Chen Chaojie Chen Xingya Wang Source Type: research

Hydroxyl safflower yellow B combined with doxorubicin inhibits the proliferation of human breast cancer MCF-7 cells
Oncol Lett. 2021 May;21(5):426. doi: 10.3892/ol.2021.12687. Epub 2021 Mar 29.ABSTRACTDoxorubicin (DOX) is currently the preferred chemotherapeutic agent for breast cancer, and hydroxyl safflower yellow B (HSYB) has a tumor growth-inhibiting activity. The present study aimed to investigate the effects of HSYB combined with DOX on the proliferation of human breast cancer MCF-7 cells and explore the underlying mechanism. MTT and cell colony formation assays revealed that the proliferation rate of MCF-7 cells was signifiscantly decreased after HSYB and DOX treatment. Combined HSYB and DOX treatment significantly decreased the ...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Kehao Lin Ze Qin Chuanjun Qu Xiaoyu Chen Qingling Jiang Minjing Li Qiusheng Zheng Defang Li Source Type: research

miR-20a-5p inhibits endometrial cancer progression by targeting janus kinase 1
Oncol Lett. 2021 May;21(5):427. doi: 10.3892/ol.2021.12688. Epub 2021 Mar 30.ABSTRACTEndometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC. Whether miR-20a-5p could inhibit EC progression by targeting janus kinase 1 (Jak1) was subsequently investigated. To do so, human EC tissues and paracancerous tissues were collected from 47 p...
Source: Oncology Letters - April 14, 2021 Category: Cancer & Oncology Authors: Ying He Hui Ma Jing Wang Yanhua Kang Qianlong Xue Source Type: research

Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis
Oncol Lett. 2021 May;21(5):381. doi: 10.3892/ol.2021.12642. Epub 2021 Mar 16.ABSTRACTVulvar squamous cell carcinoma (VSCC) comprises two distinct etiopathological subtypes: i) Human papilloma virus (HPV)-related VSCC, which arises via the precursor high grade squamous intraepithelial lesion (HSIL); and ii) HPV-independent VSCC, which arises via precursor, differentiated vulvar intraepithelial neoplasia (dVIN), driven by TP53 mutations. However, the mechanism of carcinogenesis of VSCC is poorly understood. The current study aimed to gain insight into VSCC carcinogenesis by identifying differentially expressed genes (DEGs) f...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Shatavisha Dasgupta Patricia C Ewing-Graham Thierry P P Van Den Bosch Sigrid M A Swagemakers Lindy A M Santegoets Helena C Van Doorn Peter J Van Der Spek Senada Koljenovi ć Folkert J Van Kemenade Source Type: research

Diagnostic significance of plasma lipid markers and machine learning-based algorithm for gastric cancer
In conclusion, the outcomes of the present study suggested the potential future application of the aforementioned system in clinical settings. By accumulating more reliable data, the present system will be able to detect early-stage cancer and will be capable of predicting the efficacy of each therapeutic strategy.PMID:33841566 | PMC:PMC8020384 | DOI:10.3892/ol.2021.12666 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Ryo Saito Kentaro Yoshimura Katsutoshi Shoda Shinji Furuya Hidenori Akaike Yoshihiko Kawaguchi Tasuku Murata Koretsugu Ogata Tomohiko Iwano Sen Takeda Daisuke Ichikawa Source Type: research

Construction of < em > in vitro < /em > patient-derived tumor models to evaluate anticancer agents and cancer immunotherapy
Oncol Lett. 2021 May;21(5):406. doi: 10.3892/ol.2021.12667. Epub 2021 Mar 22.ABSTRACTAn in vitro assay system using patient-derived tumor models represents a promising preclinical cancer model that replicates the disease better than traditional cell culture models. Patient-derived tumor organoid (PDO) and patient-derived tumor xenograft (PDX) models have been previously established from different types of human tumors to recapitulate accurately and efficiently their tissue architecture and function. However, these models have low throughput and are challenging to construct. Thus, the present study aimed to establish a simp...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Nobuhiko Takahashi Arisa Higa Gen Hiyama Hirosumi Tamura Hirotaka Hoshi Yuu Dobashi Kiyoaki Katahira Hiroya Ishihara Kosuke Takagi Kazuhito Goda Naoyuki Okabe Satoshi Muto Hiroyuki Suzuki Kenju Shimomura Shinya Watanabe Motoki Takagi Source Type: research

Transcription factor forkhead box K1 regulates miR-32 expression and enhances cell proliferation in colorectal cancer
Oncol Lett. 2021 May;21(5):407. doi: 10.3892/ol.2021.12668. Epub 2021 Mar 22.ABSTRACTIncreased microRNA (miR)-32 expression in colorectal cancer (CRC) tissues enhances CRC cell proliferation, migration, invasion and attenuates CRC cell apoptosis by repressing the expression of phosphatase and tensin homolog (PTEN). Forkhead box K1 (FOXK1) was identified as a potential interacting transcription factor using DNA pull-down assays and mass spectrometry. The present study aimed to elucidate the role of FOXK1 in regulating miR-32 expression in CRC. The expressions of FOXK1, miR-32, transmembrane protein 245 gene (TMEM245) and PT...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Weiyun Wu Yongze Chen Shicai Ye Hui Yang Jianyun Yang Juanhua Quan Source Type: research

Dermatopontin as a potential pathogenic factor in endometrial cancer
Oncol Lett. 2021 May;21(5):408. doi: 10.3892/ol.2021.12669. Epub 2021 Mar 22.ABSTRACTThe present study aimed to determine the differential expression profiles of proteins in endometrial carcinoma and to screen the proteins associated with the occurrence and development of endometrial cancer (EC). In total, 15 samples of human EC and paracancerous tissues were selected for proteomic analysis using a label-free quantification method based on liquid chromatography-tandem mass spectrometry. The differential proteins were analysed using bioinformatics and verified using reverse transcription-quantitative PCR (RT-qPCR) and weste...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Haiyun Huang Zhixiang Hao Lingyan Long Zeyuan Yin Chenyu Wu Xueyan Zhou Bei Zhang Source Type: research

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells
Oncol Lett. 2021 May;21(5):409. doi: 10.3892/ol.2021.12670. Epub 2021 Mar 22.ABSTRACTLiver cancer is one of the most common malignant tumors with no available satisfactory treatment. The aim of the present study was to investigate the anti-tumor effect of an irradiated hepatocellular carcinoma (HCC) whole-cell vaccine and its underlying mechanisms. Hepa1-6 and H22 HCC cell lines were irradiated in preparation for whole-cell vaccine production. Subsequently, two HCC tumor-bearing mouse models were created by injecting these Hepa1-6 and H22 cells into the abdominal skin of C57BL/6 and ICR mice, respectively. The mice were im...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Junying Chen Yuxiong Ding Fei Huang Ruilong Lan Zeng Wang Weikang Huang Ruiqing Chen Bing Wu Lengxi Fu Yunhua Yang Jun Liu Jinsheng Hong Weijian Zhang Lurong Zhang Source Type: research

High expression levels of centromere protein A plus upregulation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway affect chemotherapy response and prognosis in patients with breast cancer
Oncol Lett. 2021 May;21(5):410. doi: 10.3892/ol.2021.12671. Epub 2021 Mar 22.ABSTRACTCentromere proteins (CENPs) are involved in mitosis, and CENP gene expression levels are associated with chemotherapy responses in patients with breast cancer. The present study aimed to examine the roles and underlying mechanisms of the effects of CENP genes on chemotherapy responses and breast cancer prognosis. Using data obtained from the Gene Expression Omnibus (GEO) database, correlation and Cox multivariate regression analyses were used to determine the CENP genes associated with chemotherapy responses and survival in patients with b...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Songbo Zhang Yanyan Xie Ting Tian Qianru Yang Yuting Zhou Juanjuan Qiu Li Xu Nan Wen Qing Lv Zhenggui Du Source Type: research

Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer
Oncol Lett. 2021 May;21(5):411. doi: 10.3892/ol.2021.12672. Epub 2021 Mar 22.ABSTRACTE2F transcription factor 3 (E2F3) plays a vital role in the development of various types of cancer. To verify whether E2F3 is a suitable biomarker for the prognosis of lung cancer, bioinformatics analysis was performed to determine the differential expression level of E2F3 in lung cancer and the surrounding non-tumor tissues, and the results were confirmed in a NSCLC cell line and a tissue microarray (TMA). The relevance of E2F3 in non-small cell lung cancer (NSCLC) was investigated in 19 studies from the Oncomine database and confirmed in...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Lei Wu Shan Wan Jinfan Li Yiying Xu Xiaoli Lou Maomin Sun Shouli Wang Source Type: research

lncRNA transcription factor 7 is related to deteriorating clinical features and poor prognosis in multiple myeloma, and its knockdown suppresses disease progression by regulating the miR-203-mediated Jagged1-Notch1 signaling pathway
In conclusion, increased lnc-TCF7 expression was related to deteriorating clinical features and prognosis, and lnc-TCF7-knockdown inhibited disease progression by regulating the miR-203-mediated Jagged1-Notch1 signaling pathway activation in MM.PMID:33841573 | PMC:PMC8020383 | DOI:10.3892/ol.2021.12673 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Haiyan Liu Yaodong Shen Ya Xu Li Wang Chenlu Zhang Yijing Jiang Lemin Hong Hongming Huang Hong Liu Source Type: research

Role of cancer-associated fibroblasts in the resistance to antitumor therapy, and their potential therapeutic mechanisms in non-small cell lung cancer
Oncol Lett. 2021 May;21(5):413. doi: 10.3892/ol.2021.12674. Epub 2021 Mar 23.ABSTRACTNon-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality rates, which seriously endangers human health. Although treatment methods continue to evolve, the emergence of drug resistance is inevitable and seriously hinders the treatment of NSCLC. The tumor microenvironment (TME) protects tumor cells from the effects of chemotherapeutic drugs, which can lead to drug resistance. Cancer-associated fibroblasts (CAFs) are an important component of the TME, and various studies have demonstrated that CAFs play a cruc...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Congcong Chen Jia Hou Sizhe Yu Wenyuan Li Xiao Wang Hong Sun Tianjie Qin Francois X Claret Hui Guo Zhiyan Liu Source Type: research

Different role of MSLN and CA125 co-expression as a prognostic predictor between perihilar and distal bile duct carcinoma
Oncol Lett. 2021 May;21(5):414. doi: 10.3892/ol.2021.12675. Epub 2021 Mar 23.ABSTRACTRecent studies have suggested that the interaction of mesothelin (MSLN) and cancer antigen 125 (CA125) enhances tumor metastases. The aim of the present study was to clarify the impact of MSLN and CA125 co-expression on the prognosis of patients with extrahepatic bile duct carcinoma (BDC). Tissue samples from patients who underwent surgical resection between 2007 and 2015 for perihilar or distal BDC were immunohistochemically examined. The expression levels of MSLN and CA125 in tumor cells were analyzed. The expression in
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Yasuhiro Takihata Takahiro Einama Kazuki Kobayashi Takafumi Suzuki Naoto Yonamine Ibuki Fujinuma Takazumi Tsunenari Yoji Yamagishi Toshimitsu Iwasaki Yoichi Miyata Eiji Shinto Sho Ogata Hironori Tsujimoto Hideki Ueno Yoji Kishi Source Type: research

Erratum: Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP-2 and MMP-9 expression via the p38MAPK signaling pathway
Oncol Lett. 2021 May;21(5):415. doi: 10.3892/ol.2021.12676. Epub 2021 Mar 24.ABSTRACT[This corrects the article DOI: 10.3892/ol.2017.7080.].PMID:33841576 | PMC:PMC8020394 | DOI:10.3892/ol.2021.12676 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Shuming Lu Zhuqing Zhang Meiru Chen Chunyan Li Lina Liu Yan Li Source Type: research

circCCDC66 promotes thyroid cancer cell proliferation, migratory and invasive abilities and glycolysis through the miR-211-5p/PDK4 axis
In conclusion, the present study demonstrated that circCCDC66 could promote TC cell proliferation, migratory and invasive abilities and invasion and glycolysis through the miR-211-5p/PDK4 axis. These findings suggested that targeting circCCDC66 may be considered as a promising therapeutic strategy for TC.PMID:33841577 | PMC:PMC8020395 | DOI:10.3892/ol.2021.12677 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Hong Ren Zhendi Song Chen Chao Weizheng Mao Source Type: research

Improved understanding of gastrointestinal stromal tumors biology as a step for developing new diagnostic and therapeutic schemes
Oncol Lett. 2021 May;21(5):417. doi: 10.3892/ol.2021.12678. Epub 2021 Mar 28.ABSTRACTA gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the human gastrointestinal tract, with an estimated incidence of 10-15 per 1 million per year. While preparing holistic care for patients with GIST diagnosis, scientists might face several difficulties - insufficient risk stratification, acquired or secondary resistance to imatinib, or the need for an exceptional therapy method associated with wild-type tumors. This review summarizes recent advances associated with GIST biology that might enhance diagnostic and...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Marta Magdalena Fudalej Anna Maria Badowska-Kozakiewicz Source Type: research

Antiaging gene Klotho regulates epithelial-mesenchymal transition and increases sensitivity to pemetrexed by inducing lipocalin-2 expression
Oncol Lett. 2021 May;21(5):418. doi: 10.3892/ol.2021.12679. Epub 2021 Mar 28.ABSTRACTEpithelial-mesenchymal transition (EMT) is considered to serve an important role in the metastatic/invasive ability of cancer cells, in the acquisition of drug resistance, and in metabolic reprogramming. In the present study, it was hypothesized that the Klotho gene is involved in the metastatic/invasive ability of lung cancer. We previously reported an association between Klotho expression and overall survival in patients with small cell lung cancer and large cell neuroendocrine cancer. We also found that Klotho expression was associated ...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Kyoshiro Takegahara Jitsuo Usuda Tatsuya Inoue Takumi Sonokawa Takuma Matsui Mitsuo Matsumoto Source Type: research

Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis
Oncol Lett. 2021 May;21(5):419. doi: 10.3892/ol.2021.12680. Epub 2021 Mar 28.ABSTRACTGastric cancer (GC) has a high morbidity and mortality, hence it is very important to elucidate the molecular pathogenesis mechanism of GC progression in order to find new treatment strategies. The present study aimed to explore the biological function of circular RNA_100395 (circRNA_100395) in GC. The expression level of circRNA_100395 in GC tissues, as well as normal epithelial cells and various gastric cancer cell lines, was detected using reverse transcription-quantitative PCR. Cell Counting Kit-8, EdU assay, flow cytometry and Transwe...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Zhiyi Cheng Guiyuan Liu Chuanjiang Huang Xiaojun Zhao Source Type: research

The feasibility of circulating tumor DNA analysis as a marker of recurrence in triple-negative breast cancer
In conclusion, the present study evaluated a high-sensitivity detection system for frequently mutated genes that was also applicable for cell-free DNA. The PI3K/AKT pathway was revealed to be activated in patients harboring PIK3CA H1047R and AKT1 E17K mutations; therefore, the PI3K/AKT pathway may be a promising candidate for targeted therapy in these patients.PMID:33841581 | PMC:PMC8020385 | DOI:10.3892/ol.2021.12681 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Satoshi Okazaki Takaaki Sasaki Shunsuke Yasuda Masahiro Abe Nana Yoshida Ryohei Yoshida Kei Ishibashi Yoshinori Minami Shunsuke Okumura Shinichi Chiba Hidehiro Takei Ryusuke Hayashi Toshihiro Nagato Hiroya Kobayashi Ayumu Sugitani Yusuke Ono Yusuke Mizuka Source Type: research

Nuclear factor IB is downregulated in vulvar squamous cell carcinoma (VSCC): Unravelling differentially expressed genes in VSCC through gene expression dataset analysis
Oncol Lett. 2021 May;21(5):381. doi: 10.3892/ol.2021.12642. Epub 2021 Mar 16.ABSTRACTVulvar squamous cell carcinoma (VSCC) comprises two distinct etiopathological subtypes: i) Human papilloma virus (HPV)-related VSCC, which arises via the precursor high grade squamous intraepithelial lesion (HSIL); and ii) HPV-independent VSCC, which arises via precursor, differentiated vulvar intraepithelial neoplasia (dVIN), driven by TP53 mutations. However, the mechanism of carcinogenesis of VSCC is poorly understood. The current study aimed to gain insight into VSCC carcinogenesis by identifying differentially expressed genes (DEGs) f...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Shatavisha Dasgupta Patricia C Ewing-Graham Thierry P P Van Den Bosch Sigrid M A Swagemakers Lindy A M Santegoets Helena C Van Doorn Peter J Van Der Spek Senada Koljenovi ć Folkert J Van Kemenade Source Type: research

Diagnostic significance of plasma lipid markers and machine learning-based algorithm for gastric cancer
In conclusion, the outcomes of the present study suggested the potential future application of the aforementioned system in clinical settings. By accumulating more reliable data, the present system will be able to detect early-stage cancer and will be capable of predicting the efficacy of each therapeutic strategy.PMID:33841566 | PMC:PMC8020384 | DOI:10.3892/ol.2021.12666 (Source: Oncology Letters)
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Ryo Saito Kentaro Yoshimura Katsutoshi Shoda Shinji Furuya Hidenori Akaike Yoshihiko Kawaguchi Tasuku Murata Koretsugu Ogata Tomohiko Iwano Sen Takeda Daisuke Ichikawa Source Type: research

Construction of < em > in vitro < /em > patient-derived tumor models to evaluate anticancer agents and cancer immunotherapy
Oncol Lett. 2021 May;21(5):406. doi: 10.3892/ol.2021.12667. Epub 2021 Mar 22.ABSTRACTAn in vitro assay system using patient-derived tumor models represents a promising preclinical cancer model that replicates the disease better than traditional cell culture models. Patient-derived tumor organoid (PDO) and patient-derived tumor xenograft (PDX) models have been previously established from different types of human tumors to recapitulate accurately and efficiently their tissue architecture and function. However, these models have low throughput and are challenging to construct. Thus, the present study aimed to establish a simp...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Nobuhiko Takahashi Arisa Higa Gen Hiyama Hirosumi Tamura Hirotaka Hoshi Yuu Dobashi Kiyoaki Katahira Hiroya Ishihara Kosuke Takagi Kazuhito Goda Naoyuki Okabe Satoshi Muto Hiroyuki Suzuki Kenju Shimomura Shinya Watanabe Motoki Takagi Source Type: research

Transcription factor forkhead box K1 regulates miR-32 expression and enhances cell proliferation in colorectal cancer
Oncol Lett. 2021 May;21(5):407. doi: 10.3892/ol.2021.12668. Epub 2021 Mar 22.ABSTRACTIncreased microRNA (miR)-32 expression in colorectal cancer (CRC) tissues enhances CRC cell proliferation, migration, invasion and attenuates CRC cell apoptosis by repressing the expression of phosphatase and tensin homolog (PTEN). Forkhead box K1 (FOXK1) was identified as a potential interacting transcription factor using DNA pull-down assays and mass spectrometry. The present study aimed to elucidate the role of FOXK1 in regulating miR-32 expression in CRC. The expressions of FOXK1, miR-32, transmembrane protein 245 gene (TMEM245) and PT...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Weiyun Wu Yongze Chen Shicai Ye Hui Yang Jianyun Yang Juanhua Quan Source Type: research

Dermatopontin as a potential pathogenic factor in endometrial cancer
Oncol Lett. 2021 May;21(5):408. doi: 10.3892/ol.2021.12669. Epub 2021 Mar 22.ABSTRACTThe present study aimed to determine the differential expression profiles of proteins in endometrial carcinoma and to screen the proteins associated with the occurrence and development of endometrial cancer (EC). In total, 15 samples of human EC and paracancerous tissues were selected for proteomic analysis using a label-free quantification method based on liquid chromatography-tandem mass spectrometry. The differential proteins were analysed using bioinformatics and verified using reverse transcription-quantitative PCR (RT-qPCR) and weste...
Source: Oncology Letters - April 12, 2021 Category: Cancer & Oncology Authors: Haiyun Huang Zhixiang Hao Lingyan Long Zeyuan Yin Chenyu Wu Xueyan Zhou Bei Zhang Source Type: research