Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin
Oncol Lett. 2022 Feb;23(2):61. doi: 10.3892/ol.2021.13179. Epub 2021 Dec 27.ABSTRACTUrothelial carcinoma (UC) is one of the most common cancer types of the urinary tract. UC is associated with poor 5-year survival rate, and resistance to cisplatin-based therapy remains a challenge for invasive bladder cancer treatment. Therefore, there is an urgent need to develop new drugs for advanced UC therapy. Auranofin (AF) was developed over 30 years ago for the treatment of rheumatoid arthritis and has been reported to exert an antitumor effect by increasing the level of reactive oxygen species (ROS) in cancer cells. The aim of the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: San-Yuan Chen Chun-Nun Chao Hsin-Yi Huang Chiung-Yao Fang Source Type: research

TCF12 activates MAGT1 expression to regulate the malignant progression of pancreatic carcinoma cells
Oncol Lett. 2022 Feb;23(2):62. doi: 10.3892/ol.2021.13180. Epub 2021 Dec 27.ABSTRACTAs a highly malignant gastrointestinal tumor, pancreatic carcinoma (PC) has poor prognosis due to its low early diagnosis rate, advanced tumor resection and chemotherapy resistance. Magnesium transporter 1 (MAGT1) is a magnesium ion transporter located on the cell membrane, which shows promotive effects on biological behaviors of multiple tumor cells. The aim of the present study was to investigate the role of MAGT1 in the progression of PC and its potential molecular mechanism. Based on the Gene Expression Profiling Interactive Analysis we...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ling Wang Yanjiao Tang Hongyi Wu Guiqiu Shan Source Type: research

PKMYT1 regulates the proliferation and epithelial-mesenchymal transition of oral squamous cell carcinoma cells by targeting CCNA2
Oncol Lett. 2022 Feb;23(2):63. doi: 10.3892/ol.2021.13181. Epub 2021 Dec 27.ABSTRACTOral squamous cell carcinoma (OSCC) has gradually become a global public health issue in recent years. Therefore, the current study aimed to explore the mechanism of OSCC development and to identify a potential target that may be used in its treatment. The expression of protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1) and cyclin A2 (CCNA2) in SCC-9 cells was determined prior to and following transfection with short hairpin RNA targeting PKMYT1. Cell proliferation, colony-forming ability, migration and invasion were determin...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ye Cai Weidong Yang Source Type: research

Establishment and characterization of NCC-DMM1-C1, a novel patient-derived cell line of desmoplastic malignant pleural mesothelioma
Oncol Lett. 2022 Feb;23(2):64. doi: 10.3892/ol.2021.13182. Epub 2021 Dec 27.ABSTRACTDesmoplastic malignant pleural mesothelioma (DMM) is a rare histological variant of malignant pleural mesothelioma, which is a highly aggressive neoplasm of the mesothelium. DMM is associated with distant metastases and short survival. Effective treatments for DMM are not established and the development of histotype-tailored treatments is difficult due to the rarity of the disease. Although patient-derived cancer models are crucial tools for the development of novel therapeutics, they are difficult to obtain for DMM; no DMM cell lines or xe...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Rei Noguchi Yuki Yoshimatsu Takuya Ono Akane Sei Noriko Motoi Yasushi Yatabe Yukihiro Yoshida Shunichi Watanabe Tadashi Kondo Source Type: research

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
Oncol Lett. 2022 Feb;23(2):65. doi: 10.3892/ol.2022.13184. Epub 2022 Jan 3.ABSTRACTThe Wilms' tumor gene WT1 is highly expressed in various malignancies and may be a common target antigen for cancer immunotherapy. In our group, peptide-based cancer vaccines targeting WT1 CTL epitopes were developed as an immunotherapy for these malignancies. In the present study, WT1 epitope-specific immune responses were analyzed in 31 patients with advanced sarcoma with human leukocyte antigen-A*24:02- and WT1-expressing tumors who received the WT1-235 peptide vaccine as monotherapy. The serum levels of IgG and IgM antibodies against the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Shouq Alzaaqi Norifumi Naka Kenichiro Hamada Naoki Hosen Mizuki Kanegae Hidetatsu Outani Mayuko Adachi Rin Imanishi Eiichi Morii Miki Iwai Jun Nakata Fumihiro Fujiki Soyoko Morimoto Hiroko Nakajima Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Haruo Sugiy Source Type: research

Tetramethylpyrazine inhibits the proliferation, invasiveness and migration of cervical cancer C33A cells by retarding the Hedgehog signaling pathway
In conclusion, TMP inhibited the proliferation, migration and invasiveness of CC cells via inhibition of the Hh signaling pathway.PMID:35069875 | PMC:PMC8756559 | DOI:10.3892/ol.2022.13185 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Jing Ren Jiping Cai Changfeng Wang Source Type: research

MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression
Oncol Lett. 2022 Feb;23(2):67. doi: 10.3892/ol.2022.13186. Epub 2022 Jan 3.ABSTRACTFerroptosis is a novel form of regulated cell death characterized by accumulated lipid reactive oxygen species (ROS) and inactivation of glutathione peroxidase 4 (GPX4). The present study aimed to investigate the role of microRNA (miRNA/miR)-15a in ferroptosis of prostate cancer cells. Bioinformatics analysis was performed to predict the potential interaction between miR-15a and the 3'-untranslated region (UTR) of GPX4 mRNA. The prostate cancer cell line, LNCAP was transfected with miR-15a mimics or small interfering (si)-GPX4. Reverse trans...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Po Xu Ying Wang Zhe Deng Zhibo Tan Xiaojuan Pei Source Type: research

Spectrum of < em > MAP3K1 < /em > mutations in breast cancer is luminal subtype-predominant and related to prognosis
Oncol Lett. 2022 Feb;23(2):68. doi: 10.3892/ol.2022.13187. Epub 2022 Jan 3.ABSTRACTMAP3K1 is a MAPK family serine-threonine kinase that is frequently mutated in human cancer. The association between mutations in the MAP3K1 gene and the clinicopathological characteristics and prognosis of patients with breast cancer remain unclear in the Chinese population. Thus, the aim of the present retrospective study was to investigate the possible role and function of MAP3K1 in breast cancer. Data obtained from 412 consecutive patients with breast cancer were selected from Guangdong Provincial People's Hospital (GDPH) for analysis in ...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Cheukfai Li Guochun Zhang Yulei Wang Bo Chen Kai Li Li Cao Chongyang Ren Lingzhu Wen Minghan Jia Hsiaopei Mok Jianguo Lai Weikai Xiao Xuerui Li Ning Liao Source Type: research

Erratum: LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
Oncol Lett. 2022 Feb;23(2):69. doi: 10.3892/ol.2022.13188. Epub 2022 Jan 4.ABSTRACT[This corrects the article DOI: 10.3892/ol.2016.5514.].PMID:35069878 | PMC:PMC8756400 | DOI:10.3892/ol.2022.13188 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Haifeng Wang Yigang Zuo Mingxia Ding Changxing Ke Ruping Yan Hui Zhan Jingyu Liu Wei Wang Ning Li Jiansong Wang Source Type: research

CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect
Oncol Lett. 2022 Feb;23(2):70. doi: 10.3892/ol.2022.13190. Epub 2022 Jan 5.ABSTRACTColorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide, with a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is upregulated in CRC and is involved in regulating the apoptosis, proliferation, and drug sensitivity of CRC cells. However, the specific underlying mechanisms remain to be elucidated. The aim of the present study was to investigate the effects of CRNDE on the Warburg effect in CRC cells, as well as the associated mechanisms. The expression of CRNDE in HCT-116 ce...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Wenyu Yang Yanchun Wang Chunhui Tao Yunhai Li Shan Cao Xiqian Yang Source Type: research

Mutations in the helix αC of the catalytic domain from the EGFR affect its activity in cervical cancer cell lines
Oncol Lett. 2022 Feb;23(2):71. doi: 10.3892/ol.2022.13191. Epub 2022 Jan 5.ABSTRACTThe EGFR is a protein that belongs to the ErbB family of tyrosine kinase receptors. The EGFR is often overexpressed in human carcinomas. Amplification of the EGFR gene and mutations in the EGFR tyrosine kinase domain occur in patients with cancer. In cervical cancer, the expression level of the EGFR protein appears to directly associate with human papillomavirus infection. Our previous research demonstrated that in the cervical cancer cell lines, CALO and INBL, the EGFR is non-phosphorylated. The aim of the current study was to analyze the c...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Arturo Valle-Mendiola Ricardo Bustos-Rodr íguez Vanihamin Dom ínguez-Melendez Octavio Zerecero-Carre ón Adriana Guti érrez-Hoya Benny Weiss-Steider Isabel Soto-Cruz Source Type: research

Immune-related gene expression in skin, inflamed and keloid tissue from patients with keloids
Oncol Lett. 2022 Feb;23(2):72. doi: 10.3892/ol.2022.13192. Epub 2022 Jan 5.ABSTRACTKeloids are a tumor-like fibroproliferative skin disease that could cause disfigurement and disability. The pathological mechanisms underlying this condition remain unclear, particularly the progression from normal healthy skin to inflammatory skin tissue, then keloid. In the present study, three immune-related gene expression profiling datasets, were obtained from normal skin tissue (N group), inflamed tissue (I group) and keloid tissue samples from patients with keloids (K group). This sample grouping represents the primary steps of keloid...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Mengjie Shan Hao Liu Kexin Song Shu Liu Yan Hao Youbin Wang Source Type: research

Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin
Oncol Lett. 2022 Feb;23(2):61. doi: 10.3892/ol.2021.13179. Epub 2021 Dec 27.ABSTRACTUrothelial carcinoma (UC) is one of the most common cancer types of the urinary tract. UC is associated with poor 5-year survival rate, and resistance to cisplatin-based therapy remains a challenge for invasive bladder cancer treatment. Therefore, there is an urgent need to develop new drugs for advanced UC therapy. Auranofin (AF) was developed over 30 years ago for the treatment of rheumatoid arthritis and has been reported to exert an antitumor effect by increasing the level of reactive oxygen species (ROS) in cancer cells. The aim of the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: San-Yuan Chen Chun-Nun Chao Hsin-Yi Huang Chiung-Yao Fang Source Type: research

TCF12 activates MAGT1 expression to regulate the malignant progression of pancreatic carcinoma cells
Oncol Lett. 2022 Feb;23(2):62. doi: 10.3892/ol.2021.13180. Epub 2021 Dec 27.ABSTRACTAs a highly malignant gastrointestinal tumor, pancreatic carcinoma (PC) has poor prognosis due to its low early diagnosis rate, advanced tumor resection and chemotherapy resistance. Magnesium transporter 1 (MAGT1) is a magnesium ion transporter located on the cell membrane, which shows promotive effects on biological behaviors of multiple tumor cells. The aim of the present study was to investigate the role of MAGT1 in the progression of PC and its potential molecular mechanism. Based on the Gene Expression Profiling Interactive Analysis we...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ling Wang Yanjiao Tang Hongyi Wu Guiqiu Shan Source Type: research

PKMYT1 regulates the proliferation and epithelial-mesenchymal transition of oral squamous cell carcinoma cells by targeting CCNA2
Oncol Lett. 2022 Feb;23(2):63. doi: 10.3892/ol.2021.13181. Epub 2021 Dec 27.ABSTRACTOral squamous cell carcinoma (OSCC) has gradually become a global public health issue in recent years. Therefore, the current study aimed to explore the mechanism of OSCC development and to identify a potential target that may be used in its treatment. The expression of protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1) and cyclin A2 (CCNA2) in SCC-9 cells was determined prior to and following transfection with short hairpin RNA targeting PKMYT1. Cell proliferation, colony-forming ability, migration and invasion were determin...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ye Cai Weidong Yang Source Type: research

Establishment and characterization of NCC-DMM1-C1, a novel patient-derived cell line of desmoplastic malignant pleural mesothelioma
Oncol Lett. 2022 Feb;23(2):64. doi: 10.3892/ol.2021.13182. Epub 2021 Dec 27.ABSTRACTDesmoplastic malignant pleural mesothelioma (DMM) is a rare histological variant of malignant pleural mesothelioma, which is a highly aggressive neoplasm of the mesothelium. DMM is associated with distant metastases and short survival. Effective treatments for DMM are not established and the development of histotype-tailored treatments is difficult due to the rarity of the disease. Although patient-derived cancer models are crucial tools for the development of novel therapeutics, they are difficult to obtain for DMM; no DMM cell lines or xe...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Rei Noguchi Yuki Yoshimatsu Takuya Ono Akane Sei Noriko Motoi Yasushi Yatabe Yukihiro Yoshida Shunichi Watanabe Tadashi Kondo Source Type: research

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
Oncol Lett. 2022 Feb;23(2):65. doi: 10.3892/ol.2022.13184. Epub 2022 Jan 3.ABSTRACTThe Wilms' tumor gene WT1 is highly expressed in various malignancies and may be a common target antigen for cancer immunotherapy. In our group, peptide-based cancer vaccines targeting WT1 CTL epitopes were developed as an immunotherapy for these malignancies. In the present study, WT1 epitope-specific immune responses were analyzed in 31 patients with advanced sarcoma with human leukocyte antigen-A*24:02- and WT1-expressing tumors who received the WT1-235 peptide vaccine as monotherapy. The serum levels of IgG and IgM antibodies against the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Shouq Alzaaqi Norifumi Naka Kenichiro Hamada Naoki Hosen Mizuki Kanegae Hidetatsu Outani Mayuko Adachi Rin Imanishi Eiichi Morii Miki Iwai Jun Nakata Fumihiro Fujiki Soyoko Morimoto Hiroko Nakajima Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Haruo Sugiy Source Type: research

Tetramethylpyrazine inhibits the proliferation, invasiveness and migration of cervical cancer C33A cells by retarding the Hedgehog signaling pathway
In conclusion, TMP inhibited the proliferation, migration and invasiveness of CC cells via inhibition of the Hh signaling pathway.PMID:35069875 | PMC:PMC8756559 | DOI:10.3892/ol.2022.13185 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Jing Ren Jiping Cai Changfeng Wang Source Type: research

MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression
Oncol Lett. 2022 Feb;23(2):67. doi: 10.3892/ol.2022.13186. Epub 2022 Jan 3.ABSTRACTFerroptosis is a novel form of regulated cell death characterized by accumulated lipid reactive oxygen species (ROS) and inactivation of glutathione peroxidase 4 (GPX4). The present study aimed to investigate the role of microRNA (miRNA/miR)-15a in ferroptosis of prostate cancer cells. Bioinformatics analysis was performed to predict the potential interaction between miR-15a and the 3'-untranslated region (UTR) of GPX4 mRNA. The prostate cancer cell line, LNCAP was transfected with miR-15a mimics or small interfering (si)-GPX4. Reverse trans...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Po Xu Ying Wang Zhe Deng Zhibo Tan Xiaojuan Pei Source Type: research

Spectrum of < em > MAP3K1 < /em > mutations in breast cancer is luminal subtype-predominant and related to prognosis
Oncol Lett. 2022 Feb;23(2):68. doi: 10.3892/ol.2022.13187. Epub 2022 Jan 3.ABSTRACTMAP3K1 is a MAPK family serine-threonine kinase that is frequently mutated in human cancer. The association between mutations in the MAP3K1 gene and the clinicopathological characteristics and prognosis of patients with breast cancer remain unclear in the Chinese population. Thus, the aim of the present retrospective study was to investigate the possible role and function of MAP3K1 in breast cancer. Data obtained from 412 consecutive patients with breast cancer were selected from Guangdong Provincial People's Hospital (GDPH) for analysis in ...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Cheukfai Li Guochun Zhang Yulei Wang Bo Chen Kai Li Li Cao Chongyang Ren Lingzhu Wen Minghan Jia Hsiaopei Mok Jianguo Lai Weikai Xiao Xuerui Li Ning Liao Source Type: research

Erratum: LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
Oncol Lett. 2022 Feb;23(2):69. doi: 10.3892/ol.2022.13188. Epub 2022 Jan 4.ABSTRACT[This corrects the article DOI: 10.3892/ol.2016.5514.].PMID:35069878 | PMC:PMC8756400 | DOI:10.3892/ol.2022.13188 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Haifeng Wang Yigang Zuo Mingxia Ding Changxing Ke Ruping Yan Hui Zhan Jingyu Liu Wei Wang Ning Li Jiansong Wang Source Type: research

CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect
Oncol Lett. 2022 Feb;23(2):70. doi: 10.3892/ol.2022.13190. Epub 2022 Jan 5.ABSTRACTColorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide, with a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is upregulated in CRC and is involved in regulating the apoptosis, proliferation, and drug sensitivity of CRC cells. However, the specific underlying mechanisms remain to be elucidated. The aim of the present study was to investigate the effects of CRNDE on the Warburg effect in CRC cells, as well as the associated mechanisms. The expression of CRNDE in HCT-116 ce...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Wenyu Yang Yanchun Wang Chunhui Tao Yunhai Li Shan Cao Xiqian Yang Source Type: research

Mutations in the helix αC of the catalytic domain from the EGFR affect its activity in cervical cancer cell lines
Oncol Lett. 2022 Feb;23(2):71. doi: 10.3892/ol.2022.13191. Epub 2022 Jan 5.ABSTRACTThe EGFR is a protein that belongs to the ErbB family of tyrosine kinase receptors. The EGFR is often overexpressed in human carcinomas. Amplification of the EGFR gene and mutations in the EGFR tyrosine kinase domain occur in patients with cancer. In cervical cancer, the expression level of the EGFR protein appears to directly associate with human papillomavirus infection. Our previous research demonstrated that in the cervical cancer cell lines, CALO and INBL, the EGFR is non-phosphorylated. The aim of the current study was to analyze the c...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Arturo Valle-Mendiola Ricardo Bustos-Rodr íguez Vanihamin Dom ínguez-Melendez Octavio Zerecero-Carre ón Adriana Guti érrez-Hoya Benny Weiss-Steider Isabel Soto-Cruz Source Type: research

Immune-related gene expression in skin, inflamed and keloid tissue from patients with keloids
Oncol Lett. 2022 Feb;23(2):72. doi: 10.3892/ol.2022.13192. Epub 2022 Jan 5.ABSTRACTKeloids are a tumor-like fibroproliferative skin disease that could cause disfigurement and disability. The pathological mechanisms underlying this condition remain unclear, particularly the progression from normal healthy skin to inflammatory skin tissue, then keloid. In the present study, three immune-related gene expression profiling datasets, were obtained from normal skin tissue (N group), inflamed tissue (I group) and keloid tissue samples from patients with keloids (K group). This sample grouping represents the primary steps of keloid...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Mengjie Shan Hao Liu Kexin Song Shu Liu Yan Hao Youbin Wang Source Type: research

Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin
Oncol Lett. 2022 Feb;23(2):61. doi: 10.3892/ol.2021.13179. Epub 2021 Dec 27.ABSTRACTUrothelial carcinoma (UC) is one of the most common cancer types of the urinary tract. UC is associated with poor 5-year survival rate, and resistance to cisplatin-based therapy remains a challenge for invasive bladder cancer treatment. Therefore, there is an urgent need to develop new drugs for advanced UC therapy. Auranofin (AF) was developed over 30 years ago for the treatment of rheumatoid arthritis and has been reported to exert an antitumor effect by increasing the level of reactive oxygen species (ROS) in cancer cells. The aim of the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: San-Yuan Chen Chun-Nun Chao Hsin-Yi Huang Chiung-Yao Fang Source Type: research

TCF12 activates MAGT1 expression to regulate the malignant progression of pancreatic carcinoma cells
Oncol Lett. 2022 Feb;23(2):62. doi: 10.3892/ol.2021.13180. Epub 2021 Dec 27.ABSTRACTAs a highly malignant gastrointestinal tumor, pancreatic carcinoma (PC) has poor prognosis due to its low early diagnosis rate, advanced tumor resection and chemotherapy resistance. Magnesium transporter 1 (MAGT1) is a magnesium ion transporter located on the cell membrane, which shows promotive effects on biological behaviors of multiple tumor cells. The aim of the present study was to investigate the role of MAGT1 in the progression of PC and its potential molecular mechanism. Based on the Gene Expression Profiling Interactive Analysis we...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ling Wang Yanjiao Tang Hongyi Wu Guiqiu Shan Source Type: research

PKMYT1 regulates the proliferation and epithelial-mesenchymal transition of oral squamous cell carcinoma cells by targeting CCNA2
Oncol Lett. 2022 Feb;23(2):63. doi: 10.3892/ol.2021.13181. Epub 2021 Dec 27.ABSTRACTOral squamous cell carcinoma (OSCC) has gradually become a global public health issue in recent years. Therefore, the current study aimed to explore the mechanism of OSCC development and to identify a potential target that may be used in its treatment. The expression of protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1) and cyclin A2 (CCNA2) in SCC-9 cells was determined prior to and following transfection with short hairpin RNA targeting PKMYT1. Cell proliferation, colony-forming ability, migration and invasion were determin...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Ye Cai Weidong Yang Source Type: research

Establishment and characterization of NCC-DMM1-C1, a novel patient-derived cell line of desmoplastic malignant pleural mesothelioma
Oncol Lett. 2022 Feb;23(2):64. doi: 10.3892/ol.2021.13182. Epub 2021 Dec 27.ABSTRACTDesmoplastic malignant pleural mesothelioma (DMM) is a rare histological variant of malignant pleural mesothelioma, which is a highly aggressive neoplasm of the mesothelium. DMM is associated with distant metastases and short survival. Effective treatments for DMM are not established and the development of histotype-tailored treatments is difficult due to the rarity of the disease. Although patient-derived cancer models are crucial tools for the development of novel therapeutics, they are difficult to obtain for DMM; no DMM cell lines or xe...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Rei Noguchi Yuki Yoshimatsu Takuya Ono Akane Sei Noriko Motoi Yasushi Yatabe Yukihiro Yoshida Shunichi Watanabe Tadashi Kondo Source Type: research

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
Oncol Lett. 2022 Feb;23(2):65. doi: 10.3892/ol.2022.13184. Epub 2022 Jan 3.ABSTRACTThe Wilms' tumor gene WT1 is highly expressed in various malignancies and may be a common target antigen for cancer immunotherapy. In our group, peptide-based cancer vaccines targeting WT1 CTL epitopes were developed as an immunotherapy for these malignancies. In the present study, WT1 epitope-specific immune responses were analyzed in 31 patients with advanced sarcoma with human leukocyte antigen-A*24:02- and WT1-expressing tumors who received the WT1-235 peptide vaccine as monotherapy. The serum levels of IgG and IgM antibodies against the...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Shouq Alzaaqi Norifumi Naka Kenichiro Hamada Naoki Hosen Mizuki Kanegae Hidetatsu Outani Mayuko Adachi Rin Imanishi Eiichi Morii Miki Iwai Jun Nakata Fumihiro Fujiki Soyoko Morimoto Hiroko Nakajima Sumiyuki Nishida Akihiro Tsuboi Yoshihiro Oka Haruo Sugiy Source Type: research

Tetramethylpyrazine inhibits the proliferation, invasiveness and migration of cervical cancer C33A cells by retarding the Hedgehog signaling pathway
In conclusion, TMP inhibited the proliferation, migration and invasiveness of CC cells via inhibition of the Hh signaling pathway.PMID:35069875 | PMC:PMC8756559 | DOI:10.3892/ol.2022.13185 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Jing Ren Jiping Cai Changfeng Wang Source Type: research

MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression
Oncol Lett. 2022 Feb;23(2):67. doi: 10.3892/ol.2022.13186. Epub 2022 Jan 3.ABSTRACTFerroptosis is a novel form of regulated cell death characterized by accumulated lipid reactive oxygen species (ROS) and inactivation of glutathione peroxidase 4 (GPX4). The present study aimed to investigate the role of microRNA (miRNA/miR)-15a in ferroptosis of prostate cancer cells. Bioinformatics analysis was performed to predict the potential interaction between miR-15a and the 3'-untranslated region (UTR) of GPX4 mRNA. The prostate cancer cell line, LNCAP was transfected with miR-15a mimics or small interfering (si)-GPX4. Reverse trans...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Po Xu Ying Wang Zhe Deng Zhibo Tan Xiaojuan Pei Source Type: research

Spectrum of < em > MAP3K1 < /em > mutations in breast cancer is luminal subtype-predominant and related to prognosis
Oncol Lett. 2022 Feb;23(2):68. doi: 10.3892/ol.2022.13187. Epub 2022 Jan 3.ABSTRACTMAP3K1 is a MAPK family serine-threonine kinase that is frequently mutated in human cancer. The association between mutations in the MAP3K1 gene and the clinicopathological characteristics and prognosis of patients with breast cancer remain unclear in the Chinese population. Thus, the aim of the present retrospective study was to investigate the possible role and function of MAP3K1 in breast cancer. Data obtained from 412 consecutive patients with breast cancer were selected from Guangdong Provincial People's Hospital (GDPH) for analysis in ...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Cheukfai Li Guochun Zhang Yulei Wang Bo Chen Kai Li Li Cao Chongyang Ren Lingzhu Wen Minghan Jia Hsiaopei Mok Jianguo Lai Weikai Xiao Xuerui Li Ning Liao Source Type: research

Erratum: LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
Oncol Lett. 2022 Feb;23(2):69. doi: 10.3892/ol.2022.13188. Epub 2022 Jan 4.ABSTRACT[This corrects the article DOI: 10.3892/ol.2016.5514.].PMID:35069878 | PMC:PMC8756400 | DOI:10.3892/ol.2022.13188 (Source: Oncology Letters)
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Haifeng Wang Yigang Zuo Mingxia Ding Changxing Ke Ruping Yan Hui Zhan Jingyu Liu Wei Wang Ning Li Jiansong Wang Source Type: research

CRNDE silencing promotes apoptosis and enhances cisplatin sensitivity of colorectal carcinoma cells by inhibiting the Akt/mTORC1-mediated Warburg effect
Oncol Lett. 2022 Feb;23(2):70. doi: 10.3892/ol.2022.13190. Epub 2022 Jan 5.ABSTRACTColorectal cancer (CRC) is one of the most prevalent gastrointestinal tumors worldwide, with a high mortality rate. The lncRNA colorectal neoplasia differentially expressed (CRNDE) is upregulated in CRC and is involved in regulating the apoptosis, proliferation, and drug sensitivity of CRC cells. However, the specific underlying mechanisms remain to be elucidated. The aim of the present study was to investigate the effects of CRNDE on the Warburg effect in CRC cells, as well as the associated mechanisms. The expression of CRNDE in HCT-116 ce...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Wenyu Yang Yanchun Wang Chunhui Tao Yunhai Li Shan Cao Xiqian Yang Source Type: research

Mutations in the helix αC of the catalytic domain from the EGFR affect its activity in cervical cancer cell lines
Oncol Lett. 2022 Feb;23(2):71. doi: 10.3892/ol.2022.13191. Epub 2022 Jan 5.ABSTRACTThe EGFR is a protein that belongs to the ErbB family of tyrosine kinase receptors. The EGFR is often overexpressed in human carcinomas. Amplification of the EGFR gene and mutations in the EGFR tyrosine kinase domain occur in patients with cancer. In cervical cancer, the expression level of the EGFR protein appears to directly associate with human papillomavirus infection. Our previous research demonstrated that in the cervical cancer cell lines, CALO and INBL, the EGFR is non-phosphorylated. The aim of the current study was to analyze the c...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Arturo Valle-Mendiola Ricardo Bustos-Rodr íguez Vanihamin Dom ínguez-Melendez Octavio Zerecero-Carre ón Adriana Guti érrez-Hoya Benny Weiss-Steider Isabel Soto-Cruz Source Type: research

Immune-related gene expression in skin, inflamed and keloid tissue from patients with keloids
Oncol Lett. 2022 Feb;23(2):72. doi: 10.3892/ol.2022.13192. Epub 2022 Jan 5.ABSTRACTKeloids are a tumor-like fibroproliferative skin disease that could cause disfigurement and disability. The pathological mechanisms underlying this condition remain unclear, particularly the progression from normal healthy skin to inflammatory skin tissue, then keloid. In the present study, three immune-related gene expression profiling datasets, were obtained from normal skin tissue (N group), inflamed tissue (I group) and keloid tissue samples from patients with keloids (K group). This sample grouping represents the primary steps of keloid...
Source: Oncology Letters - January 24, 2022 Category: Cancer & Oncology Authors: Mengjie Shan Hao Liu Kexin Song Shu Liu Yan Hao Youbin Wang Source Type: research

Inhibition of p38 MAPK increases the sensitivity of 5-fluorouracil-resistant SW480 human colon cancer cells to noscapine
Oncol Lett. 2022 Feb;23(2):52. doi: 10.3892/ol.2021.13170. Epub 2021 Dec 17.ABSTRACTA major cause of treatment failure in advanced colon cancer is resistance to chemotherapy. p38 mitogen-activated protein kinase (MAPK) has been associated with cellular apoptosis and plays an important role in multidrug resistance (MDR) in cancer cells. In the present study the effect of p38 MAPK on the sensitivity of 5-fluorouracil (5-FU)-resistant SW480 (SW480/5-FU) human colon cancer cells to noscapine was investigated. Following p38 MAPK interference, the inhibitory effect of noscapine on cell viability and proliferation was increased i...
Source: Oncology Letters - January 17, 2022 Category: Cancer & Oncology Authors: Zheng Han Liu Meng Xiaodong Huang Jie Tan Weijie Liu Wei Chen Yanli Zou Yishan Cai Shasha Huang Aifang Chen Ting Zhan Min Huang Xiaoli Chen Xia Tian Qingxi Zhu Source Type: research

Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors
Oncol Lett. 2022 Feb;23(2):47. doi: 10.3892/ol.2021.13165. Epub 2021 Dec 14.ABSTRACTSolute carrier family 7 member 11 (SLC7A11) is a major transporter regulating cysteine metabolism and is widely expressed in a variety of tumor cells. SLC7A11 plays an important role in the occurrence, development, invasion and metastasis of tumors by regulating the transport of cysteine in the tumor microenvironment. SLC7A11 is expected to become a new therapeutic target and prognostic indicator for the individualized treatment of patients. According to relevant research reports, SLC7A11 can predict the stages and metastasis of liver, brea...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Xiang Tang Wei Chen Hui Liu Na Liu Deyu Chen Dalong Tian Jingzhi Wang Source Type: research

lncRNA GAS8-AS1 regulates cancer cell proliferation and predicts poor survival of patients with gastric cancer
Oncol Lett. 2022 Feb;23(2):48. doi: 10.3892/ol.2021.13166. Epub 2021 Dec 14.ABSTRACTLong non-coding (lnc)RNAs have been recognized as important regulators in gastric cancer. lncRNA GAS8-AS1 is considered a tumor suppressor in multiple types of cancer, such as papillary thyroid carcinoma, ovarian cancer and colorectal cancer. However, the specific role of GAS8-AS1 in gastric cancer remains to be fully elucidated. The aim of the present study was to investigate the role of GAS8-AS1 in gastric cancer and its potential underlying mechanisms of action. The expression levels of GAS8-AS1, microRNA (miR)-21-3p, PTEN and pyruvate d...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Chao Li Hui Wang Song Meng Jian Hong Libin Yao Yong Shao Xiaocheng Zhu Source Type: research

Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis
Oncol Lett. 2022 Feb;23(2):49. doi: 10.3892/ol.2021.13167. Epub 2021 Dec 14.ABSTRACTGTPases of immunity-associated protein 2 (GIMAP2) is a GTPase family member associated with T cell survival. However, its mechanisms of action in oral squamous cell carcinoma (OSCC) remain largely unknown. Therefore, the present study aimed to elucidate the possible role of GIMAP2 in OSCC development by investigating its expression levels and molecular mechanisms in OSCC. Reverse transcription quantitative PCR, immunoblotting and immunohistochemistry indicated that GIMAP2 expression was significantly upregulated (P
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Mari Komatsu Kengo Saito Isao Miyamoto Kazuyuki Koike Manabu Iyoda Dai Nakashima Atsushi Kasamatsu Masashi Shiiba Hideki Tanzawa Katsuhiro Uzawa Source Type: research

Paclitaxel resistance is mediated by NF- κB on mesenchymal primary breast cancer cells
Oncol Lett. 2022 Feb;23(2):50. doi: 10.3892/ol.2021.13168. Epub 2021 Dec 16.ABSTRACTPaclitaxel has been used widely to treat breast cancer and other types of cancer. However, resistance is a major cause of failure for treatment and results in cancer progression. The present study investigated the association between paclitaxel resistance and the mesenchymal phenotype, using a model of primary breast cancer cells and employing four different cultures, two with an epithelial phenotype (MBCDF and MBCD17) and two with a mesenchymal phenotype (MBCDF-D5 and MBCD3). Epithelial-mesenchymal markers were evaluated by western blottin...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Jos é Esparza-López Ossian Longoria Eliseo Neftali De La Cruz-Escobar Julio Cesar Garibay-D íaz Eucario Le ón-Rodríguez Mar ía De Jesús Ibarra-Sánchez Source Type: research

CD155 and CD112 as possible therapeutic targets of < em > FLT3 < /em > inhibitors for acute myeloid leukemia
Oncol Lett. 2022 Feb;23(2):51. doi: 10.3892/ol.2021.13169. Epub 2021 Dec 17.ABSTRACTAcute myeloid leukemia (AML) relapse is considered to be related to escape from antitumor immunity. Changes in the expression of immune checkpoints, including B7 homolog (H)1 and B7-H2, have been reported to contribute to AML progression. Binding of T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) among other immune checkpoints on natural killer (NK) and T cells to CD155/CD112 in tumors is supposed to be inhibitory; however, the mechanism by which changes in CD155 and CD112 expression affect tumor immu...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Yuta Kaito Mitsuhito Hirano Muneyoshi Futami Masanori Nojima Hideto Tamura Arinobu Tojo Yoichi Imai Source Type: research

Role of the tumor immune microenvironment in tumor immunotherapy
Oncol Lett. 2022 Feb;23(2):53. doi: 10.3892/ol.2021.13171. Epub 2021 Dec 20.ABSTRACTTumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in some patients. A minority of patients demonstrate durable responses but the majority of patients do not respond to tumor immunotherapy as the tumor immune microenvironment is different in dif...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Changsheng Zhou Qianqian Liu Yi Xiang Xin Gou Wengang Li Source Type: research

High expression of lncRNA < em > HSD11B1-AS1 < /em > indicates favorable prognosis and is associated with immune infiltration in cutaneous melanoma
Oncol Lett. 2022 Feb;23(2):54. doi: 10.3892/ol.2021.13172. Epub 2021 Dec 20.ABSTRACTCutaneous melanoma is an aggressive malignant cancer associated with poor prognosis. Identification of reliable biomarkers for predicting prognosis of melanoma contributes to improved clinical outcome and disease management. Long non-coding RNAs (lncRNAs) serve a crucial regulatory role of oncogenesis and tumor suppression in melanoma. Using data from The Cancer Genome Atlas database, novel lncRNA 11β-hydroxysteroid dehydrogenase type 1-antisense RNA 1 (HSD11B1-AS1) was identified, which was significantly downregulated in malignant mel...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Kaiyuan Liu Li Zhang Xiuli Li Jingjun Zhao Source Type: research

LINC00628 is differentially expressed between lung adenocarcinoma and squamous cell carcinoma and is associated with the prognosis of NSCLC
Oncol Lett. 2022 Feb;23(2):55. doi: 10.3892/ol.2021.13173. Epub 2021 Dec 21.ABSTRACTNon-small cell lung cancer (NSCLC) remains the most frequent malignancy worldwide, and lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) represent two major subtypes. LINC00628 has been demonstrated to promote LUAD progression; however, its clinical role in NSCLC remains elusive. The aim of the present study was to analyze the expression of long intergenic non-protein coding RNA 628 (LINC00628) in NSCLC, including in the LUAD and LUSC subtypes. In addition, its roles in NSCLC development and prognosis were also examined. Da...
Source: Oncology Letters - January 7, 2022 Category: Cancer & Oncology Authors: Tingting Liu Shuangshuang Xu Xiaoxin Liu Source Type: research