Influence of Zika virus on the cytotoxicity, cell adhesion, apoptosis and inflammatory markers of glioblastoma cells
Oncol Lett. 2024 Feb 28;27(4):176. doi: 10.3892/ol.2024.14309. eCollection 2024 Apr.ABSTRACTGlioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells, and thus could potentially be considered an alternative for GBM treatment. In the present study, two GBM cell lines (U-138 and U-251) we...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Daniel Rodrigo Marinowic Gabriele Goulart Zanirati Pamella Nunes Azevedo Ângela Zanatta Ismael Plentz Allan Marinho Alcar á Fernanda Bueno Morrone Thamiris Becker Scheffel Ang élica Regina Cappellari Paulo Michel Roehe Ana Paula Muterle Varela Denise C Source Type: research
Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta ‑analysis
In conclusion, the present meta-analysis demonstrated that the MDR1 rs1045642 polymorphism may increase the risk of breast cancer in Asian populations, is associated with a reduced risk of breast cancer in mixed populations but has no notable effect in Caucasian populations.PMID:38464339 | PMC:PMC10921258 | DOI:10.3892/ol.2024.14312 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Lili Gong Gang Hu Lihua Xu Yajuan Chen Na Wang Source Type: research
The landscape of 8q24 cytoband in gastric cancer (Review)
Oncol Lett. 2024 Feb 28;27(4):179. doi: 10.3892/ol.2024.14311. eCollection 2024 Apr.ABSTRACTWorldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24 have been frequently described; essential genes are present in this cytoband, regulating the homeostasis of crucial biological proc...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Violeta Larios-Serrato Hilda-Alicia Valdez-Salazar Martha-Eugenia Ruiz-Tachiqu ín Source Type: research
[Retracted] miR ‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion
Oncol Lett. 2024 Feb 26;27(4):175. doi: 10.3892/ol.2024.14308. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/ol.2017.7432.].PMID:38464341 | PMC:PMC10921265 | DOI:10.3892/ol.2024.14308 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Yonggen Zou Jiexiang Yang Jian Wu Cheng Luo Yuanshuai Huang Source Type: research
Liquid biopsy utilizing miRNA in patients with advanced breast cancer treated with cyclin ‑dependent kinase 4/6 inhibitors
Oncol Lett. 2024 Feb 28;27(4):181. doi: 10.3892/ol.2024.14314. eCollection 2024 Apr.ABSTRACTCyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer (ABC). Despite improvements in overall survival, most patients experience disease progression. Biomarkers derived from a liquid biopsy are appealing for their potential to detect resistance to treatment earlier than computed tomography imaging. However, clinical data concerning microRNAs (miRNAs/miRs) in the context of CDK4/6is are lacking. Thus, the presen...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Marcin Kubeczko Patrycja Tudrej Tomasz Tyszkiewicz Aleksandra Krzywon Ma Łgorzata Oczko-Wojciechowska Micha Ł JarzĄb Source Type: research
Multi ‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy
Oncol Lett. 2024 Feb 28;27(4):180. doi: 10.3892/ol.2024.14313. eCollection 2024 Apr.ABSTRACTThe present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All patients underwent conventional magnetic resonance imaging, plus IVIM and ASL imaging of the bilateral parotid glands within 2 weeks prio...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Xianhai Zhang Zhifeng Xu Yabin Jin Linwen Huang Wenxiu Wu Mingyong Gao Source Type: research
Malignant struma ovarii with synchronous primary papillary thyroid cancer in the neck: A case report and literature review
Oncol Lett. 2024 Feb 23;27(4):174. doi: 10.3892/ol.2024.14307. eCollection 2024 Apr.ABSTRACTMalignant struma ovarii (MSO) with synchronous primary thyroid cancer in the neck is extremely rare and lacks a treatment consensus. A 44-year-old woman presenting with a left ovarian cyst was admitted to Peking Union Medical College Hospital (Beijing, China) Ultrasonography showed a 6 cm solid-cystic left ovarian mass with plentiful blood signals. Other notable findings were an elevated CA125 level and a suspected malignant thyroid nodule. A unilateral salpingo-oophorectomy (USO) was conducted, and the surgical pathology was papill...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Sijian Li Ruping Hong Jiaxin Yang Source Type: research
A rare malignant mesothelioma of the tunica vaginalis testis: A case report
Oncol Lett. 2024 Feb 23;27(4):172. doi: 10.3892/ol.2024.14305. eCollection 2024 Apr.ABSTRACTMalignant mesothelioma of the tunica vaginalis testis is a rare, highly invasive urogenital malignant tumor with no specific clinical manifestations. Reported cases of this disease are limited. Therefore, an early preoperative diagnosis is difficult. The current study presents a case of malignant mesothelioma of the tunica vaginalis testis and a literature review. A 52-year-old man was admitted to Xiaoshan Affiliated Hospital of Wenzhou Medical University (Hangzhou, China) in December 2022 and underwent radical resection of the righ...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Yiqian Jiang Yong Cai Xiaoping Xu Xiangyang Kong Jianhua Cao Source Type: research
Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study
In conclusion, pretherapeutic TP, NLR and LMR are clinically feasible biomarkers for predicting the attainability of CS in patients with UR-PDAC.PMID:38455662 | PMC:PMC10918512 | DOI:10.3892/ol.2024.14304 (Source: Oncology Letters)
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Toshiya Higashi Katsutoshi Murase Daichi Watanabe Takuma Ishihara Ryoma Yokoi Masashi Kuno Masahiro Fukada Takuji Iwashita Jesse Yu Tajima Shigeru Kiyama Yoshihiro Tanaka Naoki Okumura Masahito Shimizu Nobuhisa Matsuhashi Source Type: research
Doxazosin inhibits vasculogenic mimicry in human non ‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway
In conclusion, the present study demonstrated that doxazosin displayed anti-VM activity in an NSCLC cell model through the downregulation of VEGF-A and VE-cadherin levels, and the suppression of signaling pathways related to the receptor tyrosine kinase, EphA2, protein kinases, AKT and mTOR, and proteases, MMP-2 and MMP-9. These results support the add-on anti-VM effect of doxazosin as a potential agent against NSCLC.PMID:38455663 | PMC:PMC10918514 | DOI:10.3892/ol.2024.14303 (Source: Oncology Letters)
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Jui-Ling Hsu Wohn-Jenn Leu Lih-Ching Hsu Chia-Hsun Hsieh Jih-Hwa Guh Source Type: research
Tumor reduction after SARS ‑CoV‑2 infection in a patient with lung cancer: A case report
Oncol Lett. 2024 Feb 22;27(4):169. doi: 10.3892/ol.2024.14302. eCollection 2024 Apr.ABSTRACTLung cancer is one of the most common malignancies worldwide. Since the global outbreak of the coronavirus disease 2019 (COVID-19) pandemic in 2020, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on lung cancer has been extensively studied. Despite reports about SARS-CoV-2 infection inducing a significant increase in the number of medical visits for patients with cancer, the virus has also been reported to produce some unknown benefits. The present study reports the case of a patient with lung cancer whos...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Xiaoming Zhang Jingyu Chen Jie Sun Shuyue Gao Feiyu Zhao Niansong Qian Source Type: research
Malignant struma ovarii with synchronous primary papillary thyroid cancer in the neck: A case report and literature review
Oncol Lett. 2024 Feb 23;27(4):174. doi: 10.3892/ol.2024.14307. eCollection 2024 Apr.ABSTRACTMalignant struma ovarii (MSO) with synchronous primary thyroid cancer in the neck is extremely rare and lacks a treatment consensus. A 44-year-old woman presenting with a left ovarian cyst was admitted to Peking Union Medical College Hospital (Beijing, China) Ultrasonography showed a 6 cm solid-cystic left ovarian mass with plentiful blood signals. Other notable findings were an elevated CA125 level and a suspected malignant thyroid nodule. A unilateral salpingo-oophorectomy (USO) was conducted, and the surgical pathology was papill...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Sijian Li Ruping Hong Jiaxin Yang Source Type: research
A rare malignant mesothelioma of the tunica vaginalis testis: A case report
Oncol Lett. 2024 Feb 23;27(4):172. doi: 10.3892/ol.2024.14305. eCollection 2024 Apr.ABSTRACTMalignant mesothelioma of the tunica vaginalis testis is a rare, highly invasive urogenital malignant tumor with no specific clinical manifestations. Reported cases of this disease are limited. Therefore, an early preoperative diagnosis is difficult. The current study presents a case of malignant mesothelioma of the tunica vaginalis testis and a literature review. A 52-year-old man was admitted to Xiaoshan Affiliated Hospital of Wenzhou Medical University (Hangzhou, China) in December 2022 and underwent radical resection of the righ...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Yiqian Jiang Yong Cai Xiaoping Xu Xiangyang Kong Jianhua Cao Source Type: research
Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study
In conclusion, pretherapeutic TP, NLR and LMR are clinically feasible biomarkers for predicting the attainability of CS in patients with UR-PDAC.PMID:38455662 | PMC:PMC10918512 | DOI:10.3892/ol.2024.14304 (Source: Oncology Letters)
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Toshiya Higashi Katsutoshi Murase Daichi Watanabe Takuma Ishihara Ryoma Yokoi Masashi Kuno Masahiro Fukada Takuji Iwashita Jesse Yu Tajima Shigeru Kiyama Yoshihiro Tanaka Naoki Okumura Masahito Shimizu Nobuhisa Matsuhashi Source Type: research
Doxazosin inhibits vasculogenic mimicry in human non ‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway
In conclusion, the present study demonstrated that doxazosin displayed anti-VM activity in an NSCLC cell model through the downregulation of VEGF-A and VE-cadherin levels, and the suppression of signaling pathways related to the receptor tyrosine kinase, EphA2, protein kinases, AKT and mTOR, and proteases, MMP-2 and MMP-9. These results support the add-on anti-VM effect of doxazosin as a potential agent against NSCLC.PMID:38455663 | PMC:PMC10918514 | DOI:10.3892/ol.2024.14303 (Source: Oncology Letters)
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Jui-Ling Hsu Wohn-Jenn Leu Lih-Ching Hsu Chia-Hsun Hsieh Jih-Hwa Guh Source Type: research
