Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta ‑analysis
In conclusion, the present meta-analysis demonstrated that the MDR1 rs1045642 polymorphism may increase the risk of breast cancer in Asian populations, is associated with a reduced risk of breast cancer in mixed populations but has no notable effect in Caucasian populations.PMID:38464339 | PMC:PMC10921258 | DOI:10.3892/ol.2024.14312 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Lili Gong Gang Hu Lihua Xu Yajuan Chen Na Wang Source Type: research
The landscape of 8q24 cytoband in gastric cancer (Review)
Oncol Lett. 2024 Feb 28;27(4):179. doi: 10.3892/ol.2024.14311. eCollection 2024 Apr.ABSTRACTWorldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24 have been frequently described; essential genes are present in this cytoband, regulating the homeostasis of crucial biological proc...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Violeta Larios-Serrato Hilda-Alicia Valdez-Salazar Martha-Eugenia Ruiz-Tachiqu ín Source Type: research
[Retracted] miR ‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion
Oncol Lett. 2024 Feb 26;27(4):175. doi: 10.3892/ol.2024.14308. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/ol.2017.7432.].PMID:38464341 | PMC:PMC10921265 | DOI:10.3892/ol.2024.14308 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Yonggen Zou Jiexiang Yang Jian Wu Cheng Luo Yuanshuai Huang Source Type: research
Liquid biopsy utilizing miRNA in patients with advanced breast cancer treated with cyclin ‑dependent kinase 4/6 inhibitors
Oncol Lett. 2024 Feb 28;27(4):181. doi: 10.3892/ol.2024.14314. eCollection 2024 Apr.ABSTRACTCyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer (ABC). Despite improvements in overall survival, most patients experience disease progression. Biomarkers derived from a liquid biopsy are appealing for their potential to detect resistance to treatment earlier than computed tomography imaging. However, clinical data concerning microRNAs (miRNAs/miRs) in the context of CDK4/6is are lacking. Thus, the presen...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Marcin Kubeczko Patrycja Tudrej Tomasz Tyszkiewicz Aleksandra Krzywon Ma Łgorzata Oczko-Wojciechowska Micha Ł JarzĄb Source Type: research
Multi ‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy
Oncol Lett. 2024 Feb 28;27(4):180. doi: 10.3892/ol.2024.14313. eCollection 2024 Apr.ABSTRACTThe present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All patients underwent conventional magnetic resonance imaging, plus IVIM and ASL imaging of the bilateral parotid glands within 2 weeks prio...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Xianhai Zhang Zhifeng Xu Yabin Jin Linwen Huang Wenxiu Wu Mingyong Gao Source Type: research
Cushing's syndrome caused by adrenocortical oncocytoma: A case report
Oncol Lett. 2024 Feb 28;27(4):177. doi: 10.3892/ol.2024.14310. eCollection 2024 Apr.ABSTRACTAdrenal cortical eosinophilic adenoma usually presents as non-functional adrenal tumor but may lead to Cushing's syndrome in patients. The present article reports a patient with Cushing's syndrome caused by right adrenocortical oncocytoma. The patient was treated in Urology Department of Wuchuan People's Hospital (Zunyi, China) in November 2022 because of hirsutism, weight gain and hypertension. A laparoscopic right adrenal tumor resection was performed using an abdominal approach. Following surgery, blood pressure and heart rate of...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Chengren Gou Qingsong Jian Maoqiang Tian Jinghai Li Yi Zhang Zhenyu Guo Source Type: research
A meta ‑ and bioinformatics analysis of maspin expression levels influencing the prognosis of patients with breast cancer
Oncol Lett. 2024 Feb 23;27(4):173. doi: 10.3892/ol.2024.14306. eCollection 2024 Apr.ABSTRACTMaspin is a serine protease inhibitor that is encoded by the human SERPINB5 gene. As a tumor inhibitor, it can inhibit the growth of tumor cells, increase adhesion between tumor cells and inhibit tumor angiogenesis. In the present study, a meta- and bioinformatics analysis was performed through the PubMed and China National Knowledge Infrastructure databases including entries added until up to March 20, 2023. It was found that compared with normal breast tissue, maspin expression was downregulated in breast cancer tissue. Maspin exp...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Shuai Shi Zhi-Gang Zhang Yin-Zhou Sang Jie Sun Hong-Yan Ma Source Type: research
Identification and prognostic analysis of ferroptosis ‑related gene HSPA5 to predict the progression of lung squamous cell carcinoma
In conclusion, the present study demonstrated that the expression of the ferroptosis-related gene HSPA5 may be a negative prognostic marker for LSCC.PMID:38464337 | PMC:PMC10921261 | DOI:10.3892/ol.2024.14320 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Di Guo Yonghai Feng Peijie Liu Shanshan Yang Wenfei Zhao Hongyun Li Source Type: research
Influence of Zika virus on the cytotoxicity, cell adhesion, apoptosis and inflammatory markers of glioblastoma cells
Oncol Lett. 2024 Feb 28;27(4):176. doi: 10.3892/ol.2024.14309. eCollection 2024 Apr.ABSTRACTGlioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells, and thus could potentially be considered an alternative for GBM treatment. In the present study, two GBM cell lines (U-138 and U-251) we...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Daniel Rodrigo Marinowic Gabriele Goulart Zanirati Pamella Nunes Azevedo Ângela Zanatta Ismael Plentz Allan Marinho Alcar á Fernanda Bueno Morrone Thamiris Becker Scheffel Ang élica Regina Cappellari Paulo Michel Roehe Ana Paula Muterle Varela Denise C Source Type: research
Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta ‑analysis
In conclusion, the present meta-analysis demonstrated that the MDR1 rs1045642 polymorphism may increase the risk of breast cancer in Asian populations, is associated with a reduced risk of breast cancer in mixed populations but has no notable effect in Caucasian populations.PMID:38464339 | PMC:PMC10921258 | DOI:10.3892/ol.2024.14312 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Lili Gong Gang Hu Lihua Xu Yajuan Chen Na Wang Source Type: research
The landscape of 8q24 cytoband in gastric cancer (Review)
Oncol Lett. 2024 Feb 28;27(4):179. doi: 10.3892/ol.2024.14311. eCollection 2024 Apr.ABSTRACTWorldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24 have been frequently described; essential genes are present in this cytoband, regulating the homeostasis of crucial biological proc...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Violeta Larios-Serrato Hilda-Alicia Valdez-Salazar Martha-Eugenia Ruiz-Tachiqu ín Source Type: research
[Retracted] miR ‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion
Oncol Lett. 2024 Feb 26;27(4):175. doi: 10.3892/ol.2024.14308. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/ol.2017.7432.].PMID:38464341 | PMC:PMC10921265 | DOI:10.3892/ol.2024.14308 (Source: Oncology Letters)
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Yonggen Zou Jiexiang Yang Jian Wu Cheng Luo Yuanshuai Huang Source Type: research
Liquid biopsy utilizing miRNA in patients with advanced breast cancer treated with cyclin ‑dependent kinase 4/6 inhibitors
Oncol Lett. 2024 Feb 28;27(4):181. doi: 10.3892/ol.2024.14314. eCollection 2024 Apr.ABSTRACTCyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer (ABC). Despite improvements in overall survival, most patients experience disease progression. Biomarkers derived from a liquid biopsy are appealing for their potential to detect resistance to treatment earlier than computed tomography imaging. However, clinical data concerning microRNAs (miRNAs/miRs) in the context of CDK4/6is are lacking. Thus, the presen...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Marcin Kubeczko Patrycja Tudrej Tomasz Tyszkiewicz Aleksandra Krzywon Ma Łgorzata Oczko-Wojciechowska Micha Ł JarzĄb Source Type: research
Multi ‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy
Oncol Lett. 2024 Feb 28;27(4):180. doi: 10.3892/ol.2024.14313. eCollection 2024 Apr.ABSTRACTThe present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All patients underwent conventional magnetic resonance imaging, plus IVIM and ASL imaging of the bilateral parotid glands within 2 weeks prio...
Source: Oncology Letters - March 11, 2024 Category: Cancer & Oncology Authors: Xianhai Zhang Zhifeng Xu Yabin Jin Linwen Huang Wenxiu Wu Mingyong Gao Source Type: research
Malignant struma ovarii with synchronous primary papillary thyroid cancer in the neck: A case report and literature review
Oncol Lett. 2024 Feb 23;27(4):174. doi: 10.3892/ol.2024.14307. eCollection 2024 Apr.ABSTRACTMalignant struma ovarii (MSO) with synchronous primary thyroid cancer in the neck is extremely rare and lacks a treatment consensus. A 44-year-old woman presenting with a left ovarian cyst was admitted to Peking Union Medical College Hospital (Beijing, China) Ultrasonography showed a 6 cm solid-cystic left ovarian mass with plentiful blood signals. Other notable findings were an elevated CA125 level and a suspected malignant thyroid nodule. A unilateral salpingo-oophorectomy (USO) was conducted, and the surgical pathology was papill...
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Sijian Li Ruping Hong Jiaxin Yang Source Type: research
