Tumor ‑suppressive effects of Smad‑ubiquitination regulator 2 in papillary thyroid carcinoma
Oncol Lett. 2024 Apr 10;27(6):263. doi: 10.3892/ol.2024.14396. eCollection 2024 Jun.ABSTRACTSmad-ubiquitination regulator 2 (SMURF2) functions as a homolog of E6AP carboxyl terminus-type E3 ubiquitin ligase to regulate cell cycle progression and tumor growth factor expression. SMURF2 has been revealed to function as a tumor suppressor in a number of cancers; however, its function in papillary thyroid carcinoma (PTC) remains largely unknown. Therefore, the aim of the present study was to investigate the function of SMURF2 in PTC. Reverse transcription-quantitative PCR and western blotting were used to detect cellular expres...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Guirong Luo Liting Zhang Lihong Zhang Wenyi Wu Jianqing Lin Haihong Shi Yihuang Yu Weigang Qiu Jinyan Chen Hansen Ding Xinyao Chen Source Type: research
Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)
Oncol Lett. 2024 Apr 9;27(6):256. doi: 10.3892/ol.2024.14389. eCollection 2024 Jun.ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein that is widely and moderately expressed on the surface of various cells and can have an essential role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis and other related responses by binding to its ligands, integrins, thrombospondin-1 and signal regulatory protein α. The poor prognosis of cancer patients is closely associated with high expression of CD47 in glioblastoma, ovarian cancer, breast cancer, bladder cancer, colon cancer a...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Fan Wu Hongyuan Pang Fan Li Mengqing Hua Chuanwang Song Jie Tang Source Type: research
Primary anastomosing hemangioma as a preoperative diagnostic mimicker of retroperitoneal cavernous hemangioma: A case report
Oncol Lett. 2024 Apr 9;27(6):254. doi: 10.3892/ol.2024.14386. eCollection 2024 Jun.ABSTRACTAnastomosing hemangioma (AH) is rare and a newly recognized variant of capillary hemangioma that is mostly found in the genitourinary tract. Additionally, AH is sometimes difficult to diagnose without pathological specimens. It is difficult to diagnose preoperatively due to the lack of specific clinical and radiologic appearance. The present report describes the imaging features from a radiological perspective and outlines the clinicopathologic features and treatment options. A 67-year-old woman was referred to Dokkyo Medical Univers...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Hirotaka Ishido Hidehiro Tajima Soya Meguro Musashi Takada Teppei Tatsuoka Keishi Kawasaki Yuko Ono Shinichi Ban Takashi Okuyama Hideyuki Yoshitomi Source Type: research
Clinical significance of the CXCL8/CXCR1/R2 signalling axis in patients with invasive breast cancer
Oncol Lett. 2024 Apr 10;27(6):260. doi: 10.3892/ol.2024.14393. eCollection 2024 Jun.ABSTRACTThe C-X-C motif chemokine ligand 8 (CXCL8)-C-X-C chemokine receptor (CXCR)1/2 signalling axis is among numerous mechanisms which stimulate the immune system to defend against tumour growth and influence the tumour microenvironment to promote tumour growth. This pathway plays an important role in the development of a number of cancers including breast cancer (BC). The aim of the present study was to analyse the levels of the chemokine CXCL8 and its receptors, CXCR1 and CXCR2, in the serum of female patients with invasive BC and to as...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Sebastian St ępień Marta Smycz-Kuba ńska Celina Kruszniewska-Rajs Joanna Magdalena Gola Jacek Kabut Pawe ł Olczyk Aleksandra Mielczarek-Palacz Source Type: research
Clinical prognostic significance of xeroderma pigmentosum group C and IFN ‑γ in non‑small cell lung cancer
Oncol Lett. 2024 Apr 9;27(6):259. doi: 10.3892/ol.2024.14392. eCollection 2024 Jun.ABSTRACTLung cancer is the most common cancer in the world due to its high incidence and recurrence. Genetic instability is one of the main factors leading to its occurrence, development and poor prognosis. Decreased xeroderma pigmentosum group C (XPC) expression notably enhances the stem cell properties of lung cancer cells and increases their proliferation and migration. Additionally, patients with lung cancer and low XPC expression had a poor prognosis. The purpose of the present study was to analyze the effect of XPC and IFN-γ on the cl...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Yongming Wang Weiyu Wang Huaijie Wang Liya Qin Meijia Zhang Yong Zhang Yubing Wang Changcheng Hao Meihua Qu Gongchao Wang Source Type: research
Non ‑coding RNA: A promising diagnostic biomarker and therapeutic target for esophageal squamous cell carcinoma (Review)
Oncol Lett. 2024 Apr 9;27(6):255. doi: 10.3892/ol.2024.14388. eCollection 2024 Jun.ABSTRACTEsophageal cancer (EC) is a common form of malignant tumor in the digestive system that is classified into two types: Esophageal squamous cell carcinomas (ESCC) and esophageal adenocarcinoma. ESCC is known for its early onset of symptoms, which can be difficult to identify, as well as its rapid progression and tendency to develop drug resistance to chemotherapy and radiotherapy. These factors contribute to the high incidence of disease and low cure rate. Therefore, a diagnostic biomarker and therapeutic target need to be identified f...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Longze Zhang Yanyang Wang Jianmei Gao Xue Zhou Minglei Huang Xianyao Wang Zhixu He Source Type: research
Rare retroperitoneal giant sacral schwannoma: A case report
Oncol Lett. 2024 Apr 10;27(6):261. doi: 10.3892/ol.2024.14394. eCollection 2024 Jun.ABSTRACTSchwannomas localized in the sacrum are relatively infrequent, accounting for 1-5% of all spinal axis schwannomas; they present with vague symptoms or are symptomless, so often grow to a considerable size before detection. Sacral schwannomas occasionally present with enormous dimensions, and these tumors are termed giant sacral schwannomas. However, their surgical removal is challenging owing to an abundant vascularity. The present study retrospectively analyzed the clinical and follow-up data of a patient with a giant sacral schwan...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Shunchang Zhou Shenyi Wan Liang Li Wei Dong Xuhui Ma Haibo Chu Yuxu Zhong Source Type: research
Pan ‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma
In conclusion, the PIV was a powerful predictor of survival outcomes and outperformed the SII in patients with NPC treated with chemoradiotherapy. Prospective validation of the PIV should be performed to better stratify radical treatment of patients with NPC.PMID:38646495 | PMC:PMC11027095 | DOI:10.3892/ol.2024.14385 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhen Su Jie Tang Yan He Wei Hua Zeng Qian Yu Xiao Long Cao Guo Rong Zou Source Type: research
MicroRNA ‑1224 inhibits cell proliferation by downregulating CBX3 expression in chordoma
Oncol Lett. 2024 Apr 10;27(6):262. doi: 10.3892/ol.2024.14395. eCollection 2024 Jun.ABSTRACTMicroRNAs (miRNAs/miRs) have abnormal expression in numerous tumors and are closely related to tumor development and resistance to radiotherapy and chemotherapy. However, there are few studies assessing the role and mechanism of miRNA in chordoma. The sequencing data of three pairs of chordoma and notochord tissues from the GSE56183 dataset were analyzed in the present study. Cell proliferation was assessed in vitro using Cell Counting Kit-8. Bioinformatics analysis and the dual luciferase reporter assay were used to evaluate the re...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Wei Xia Jihe Huang Chunhua Sun Fei Shen Kejia Yang Source Type: research
The numerous facets of 1q21 < sup > + < /sup > in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review)
Oncol Lett. 2024 Apr 9;27(6):258. doi: 10.3892/ol.2024.14391. eCollection 2024 Jun.ABSTRACTMultiple myeloma (MM) is a malignant neoplasm characterized by the clonal proliferation of abnormal plasma cells (PCs) in the bone marrow and recurrent cytogenetic abnormalities. The incidence of MM worldwide is on the rise. 1q21+ has been found in ~30-40% of newly diagnosed MM (NDMM) patients.1q21+ is associated with the pathophysiological mechanisms of disease progression and drug resistance in MM. In the present review, the pathogenesis and clinicopathological features of MM patients with 1q21+ were studied, the key data of 1q21+ ...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Na Liu Zhanzhi Xie Hao Li Luqun Wang Source Type: research
Metastatic breast cancer with double heterozygosity for the < em > BRCA1 < /em > and < em > BRCA2 < /em > genes responding to olaparib: A case report
In conclusion, the present study reported a female patient with double heterozygosity of BRCA1 and BRCA2 who benefited from olaparib monotherapy. Thus, olaparib may be a suitable treatment for such patients.PMID:38646498 | PMC:PMC11027096 | DOI:10.3892/ol.2024.14387 (Source: Oncology Letters)
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Bin Shao Lijun Di Source Type: research
Advances in molecular mechanisms of inflammatory bowel disease ‑associated colorectal cancer (Review)
Oncol Lett. 2024 Apr 9;27(6):257. doi: 10.3892/ol.2024.14390. eCollection 2024 Jun.ABSTRACTThe link between inflammation and cancer is well documented and colonic inflammation caused by inflammatory bowel disease (IBD) is thought to be a high-risk factor for the development of colorectal cancer (CRC). The complex crosstalk between epithelial and inflammatory cells is thought to underlie the progression from inflammation to cancer. The present review collates and summarises recent advances in the understanding of the pathogenesis of IBD-associated CRC (IBD-CRC), including the oncogenic mechanisms of the main inflammatory si...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Zhi Wang Yu Chang Haibo Sun Yuqin Li Tongyu Tang Source Type: research
Tumor ‑suppressive effects of Smad‑ubiquitination regulator 2 in papillary thyroid carcinoma
Oncol Lett. 2024 Apr 10;27(6):263. doi: 10.3892/ol.2024.14396. eCollection 2024 Jun.ABSTRACTSmad-ubiquitination regulator 2 (SMURF2) functions as a homolog of E6AP carboxyl terminus-type E3 ubiquitin ligase to regulate cell cycle progression and tumor growth factor expression. SMURF2 has been revealed to function as a tumor suppressor in a number of cancers; however, its function in papillary thyroid carcinoma (PTC) remains largely unknown. Therefore, the aim of the present study was to investigate the function of SMURF2 in PTC. Reverse transcription-quantitative PCR and western blotting were used to detect cellular expres...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Guirong Luo Liting Zhang Lihong Zhang Wenyi Wu Jianqing Lin Haihong Shi Yihuang Yu Weigang Qiu Jinyan Chen Hansen Ding Xinyao Chen Source Type: research
Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)
Oncol Lett. 2024 Apr 9;27(6):256. doi: 10.3892/ol.2024.14389. eCollection 2024 Jun.ABSTRACTCluster of differentiation 47 (CD47) is a transmembrane protein that is widely and moderately expressed on the surface of various cells and can have an essential role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis and other related responses by binding to its ligands, integrins, thrombospondin-1 and signal regulatory protein α. The poor prognosis of cancer patients is closely associated with high expression of CD47 in glioblastoma, ovarian cancer, breast cancer, bladder cancer, colon cancer a...
Source: Oncology Letters - April 22, 2024 Category: Cancer & Oncology Authors: Fan Wu Hongyuan Pang Fan Li Mengqing Hua Chuanwang Song Jie Tang Source Type: research
Prognostic value of serum tartrate ‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer
In conclusion, these findings indicated that TRACP-5b may predict bone metastasis in patients with node-positive breast cancer.PMID:38638841 | PMC:PMC11024733 | DOI:10.3892/ol.2024.14383 (Source: Oncology Letters)
Source: Oncology Letters - April 19, 2024 Category: Cancer & Oncology Authors: Masafumi Shimoda Yasufumi Sato Kaori Abe Nanae Masunaga Masami Tsukabe Tetsuhiro Yoshinami Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Kenzo Shimazu Source Type: research
