Efficacy of nab ‑paclitaxel vs. Gemcitabine in combination with S‑1 for advanced pancreatic cancer: A multicenter phase II randomized trial
Oncol Lett. 2024 Feb 19;27(4):161. doi: 10.3892/ol.2024.14293. eCollection 2024 Apr.ABSTRACTPatients with advanced pancreatic cancer (PC) need a cost-effective treatment regimen. The present study was designed to compare the efficacy and safety of nab-paclitaxel plus S-1 (AS) and gemcitabine plus S-1 (GS) regimens in patients with chemotherapy-naïve advanced PC. In this open-label, multicenter, randomized study named AvGmPC, eligible patients with chemotherapy-naïve advanced PC were randomly assigned (1:1) to receive AS (125 mg/m2 nab-paclitaxel, days 1 and 8; 80-120 mg S-1, days 1-14) or GS (1,000 mg/m2 gemcitabine, day...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Xi Guo Wenhui Lou Yaolin Xu Rongyuan Zhuang Lie Yao Junwei Wu Deliang Fu Jun Zhang Jing Liu Yefei Rong Dayong Jin Wenchuan Wu Xuefeng Xu Yuan Ji Lili Wu Minzhi Lv Xiuzhong Yao Xiaowei Liu Dansong Wang Tiantao Kuang Liang Liu Wenquan Wang Tianshu Liu Yuhon Source Type: research
Pioglitazone, a peroxisome proliferator ‑activated receptor γ agonist, induces cell death and inhibits the proliferation of hypoxic HepG2 cells by promoting excessive production of reactive oxygen species
Oncol Lett. 2024 Feb 19;27(4):160. doi: 10.3892/ol.2024.14294. eCollection 2024 Apr.ABSTRACTHypoxia is a hallmark of solid tumors. Hypoxic cancer cells adjust their metabolic characteristics to regulate the production of cellular reactive oxygen species (ROS) and facilitate ROS-mediated metastasis. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that regulates the transcription of fatty acid metabolism-related genes that have a key role in the survival and proliferation function of hypoxic cancer cells. In the present study, mRNA expression in HepG2 cells under chemically induced hypoxia was as...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Guohao Huang Mengfan Zhang Manzhou Wang Wenze Xu Xuhua Duan Xinwei Han Jianzhuang Ren Source Type: research
Effects of neoadjuvant VEGF ‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis
In conclusion, the results of the present study indicated that neoadjuvant VEGF-TKI treatment in patients with RCC shortened operation time, decreased blood loss and did not cause an increase in perioperative complications. In addition, this treatment modality may encourage patients to opt for partial nephrectomy to preserve renal function.PMID:38449796 | PMC:PMC10915807 | DOI:10.3892/ol.2024.14295 (Source: Oncology Letters)
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Meikai Zhu Zhifeng Liu Yongheng Zhou Zhiwen Jiang Shouzhen Chen Wenfu Wang Benkang Shi Yaofeng Zhu Source Type: research
Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report
Oncol Lett. 2024 Feb 22;27(4):168. doi: 10.3892/ol.2024.14301. eCollection 2024 Apr.ABSTRACTThe development of tumors in livers transplanted from hepatitis B virus (HBV)-negative donors to patients with hepatitis B and cirrhosis is rare. The present study describes the case of a woman in her 60s who developed hepatocellular carcinoma (HCC) in her grafted liver, 19 years after transplantation, as well as a metachronous colorectal tumor. The pathological findings, including clinical, immunohistochemical and molecular results, are described in the present case report. The liver tumor was a conventional HCC and the colorectal ...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Sayoko Sumiyoshi Terumi Takahara Kazuto Shibuya Johji Imura Akira Noguchi Kazuto Tajiri Masami Minemura Tsutomu Fujii Kenichi Hirabayashi Source Type: research
Extracellular cancer ‑associated fibroblasts: A novel subgroup in the cervical cancer microenvironment that exhibits tumor‑promoting roles and prognosis biomarker functions
In conclusion, the present study assessed the heterogeneity of CAFs in the cervical cancer microenvironment, and a subgroup of CAFs that may be closely associated with tumor progression was defined. Moreover, a signature based on the hub genes of ecCAFs was shown to have biomarker functionality in terms of predicting survival rates, and therefore this CAF subgroup may become a therapeutic target for cervical cancer in the future.PMID:38449793 | PMC:PMC10915806 | DOI:10.3892/ol.2024.14300 (Source: Oncology Letters)
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Yuehan Wang Mingxia Xu Yeli Yao Ying Li Songfa Zhang Yunfeng Fu Xinyu Wang Source Type: research
Efficacy of nab ‑paclitaxel vs. Gemcitabine in combination with S‑1 for advanced pancreatic cancer: A multicenter phase II randomized trial
Oncol Lett. 2024 Feb 19;27(4):161. doi: 10.3892/ol.2024.14293. eCollection 2024 Apr.ABSTRACTPatients with advanced pancreatic cancer (PC) need a cost-effective treatment regimen. The present study was designed to compare the efficacy and safety of nab-paclitaxel plus S-1 (AS) and gemcitabine plus S-1 (GS) regimens in patients with chemotherapy-naïve advanced PC. In this open-label, multicenter, randomized study named AvGmPC, eligible patients with chemotherapy-naïve advanced PC were randomly assigned (1:1) to receive AS (125 mg/m2 nab-paclitaxel, days 1 and 8; 80-120 mg S-1, days 1-14) or GS (1,000 mg/m2 gemcitabine, day...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Xi Guo Wenhui Lou Yaolin Xu Rongyuan Zhuang Lie Yao Junwei Wu Deliang Fu Jun Zhang Jing Liu Yefei Rong Dayong Jin Wenchuan Wu Xuefeng Xu Yuan Ji Lili Wu Minzhi Lv Xiuzhong Yao Xiaowei Liu Dansong Wang Tiantao Kuang Liang Liu Wenquan Wang Tianshu Liu Yuhon Source Type: research
Pioglitazone, a peroxisome proliferator ‑activated receptor γ agonist, induces cell death and inhibits the proliferation of hypoxic HepG2 cells by promoting excessive production of reactive oxygen species
Oncol Lett. 2024 Feb 19;27(4):160. doi: 10.3892/ol.2024.14294. eCollection 2024 Apr.ABSTRACTHypoxia is a hallmark of solid tumors. Hypoxic cancer cells adjust their metabolic characteristics to regulate the production of cellular reactive oxygen species (ROS) and facilitate ROS-mediated metastasis. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that regulates the transcription of fatty acid metabolism-related genes that have a key role in the survival and proliferation function of hypoxic cancer cells. In the present study, mRNA expression in HepG2 cells under chemically induced hypoxia was as...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Guohao Huang Mengfan Zhang Manzhou Wang Wenze Xu Xuhua Duan Xinwei Han Jianzhuang Ren Source Type: research
Effects of neoadjuvant VEGF ‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis
In conclusion, the results of the present study indicated that neoadjuvant VEGF-TKI treatment in patients with RCC shortened operation time, decreased blood loss and did not cause an increase in perioperative complications. In addition, this treatment modality may encourage patients to opt for partial nephrectomy to preserve renal function.PMID:38449796 | PMC:PMC10915807 | DOI:10.3892/ol.2024.14295 (Source: Oncology Letters)
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Meikai Zhu Zhifeng Liu Yongheng Zhou Zhiwen Jiang Shouzhen Chen Wenfu Wang Benkang Shi Yaofeng Zhu Source Type: research
Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report
Oncol Lett. 2024 Feb 22;27(4):168. doi: 10.3892/ol.2024.14301. eCollection 2024 Apr.ABSTRACTThe development of tumors in livers transplanted from hepatitis B virus (HBV)-negative donors to patients with hepatitis B and cirrhosis is rare. The present study describes the case of a woman in her 60s who developed hepatocellular carcinoma (HCC) in her grafted liver, 19 years after transplantation, as well as a metachronous colorectal tumor. The pathological findings, including clinical, immunohistochemical and molecular results, are described in the present case report. The liver tumor was a conventional HCC and the colorectal ...
Source: Oncology Letters - March 7, 2024 Category: Cancer & Oncology Authors: Sayoko Sumiyoshi Terumi Takahara Kazuto Shibuya Johji Imura Akira Noguchi Kazuto Tajiri Masami Minemura Tsutomu Fujii Kenichi Hirabayashi Source Type: research
Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway
In conclusion, fisetin may enhance the sensitivity of RCC cells to cisplatin via the CDK6/PI3K/Akt/mTOR signaling pathway.PMID:38426151 | PMC:PMC10902757 | DOI:10.3892/ol.2024.14298 (Source: Oncology Letters)
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Tingting Jiang Yan Liang Yenan Ji Yin Xue Source Type: research
[Retracted] Long non ‑coding RNA MALAT‑1 contributes to maintenance of stem cell‑like phenotypes in breast cancer cells
Oncol Lett. 2024 Feb 19;27(4):159. doi: 10.3892/ol.2024.14292. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/ol.2017.7557.].PMID:38426152 | PMC:PMC10902753 | DOI:10.3892/ol.2024.14292 (Source: Oncology Letters)
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Linghuan Zeng Ying Cen Junjie Chen Source Type: research
Repeated high ‑intensity focused ultrasound combined with iodine‑125 seed interstitial brachytherapy offers improved quality of life and pain control for patients with advanced pancreatic cancer: A 52‑patient retrospective study
In conclusion, the present study demonstrated the survival benefit and improvement in quality of life of patients with advanced pancreatic cancer receiving repeated HIFU treatment combined with 125I interstitial brachytherapy, which may provide new ideas and methods for the treatment of pancreatic cancer.PMID:38426153 | PMC:PMC10902751 | DOI:10.3892/ol.2024.14290 (Source: Oncology Letters)
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Yumei Liu Yongshuo Ji Junqiu Zhu Linglin Zhu Yanfei Zhu Zhijun Bao Hong Zhao Source Type: research
Iodine ‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review
Oncol Lett. 2024 Feb 15;27(4):156. doi: 10.3892/ol.2024.14289. eCollection 2024 Apr.ABSTRACTTesticular seminoma is a relatively rare malignant tumor, with the most common site of recurrence and metastasis being the retroperitoneal lymph nodes. Since seminoma is highly sensitive to radiotherapy and chemotherapy, even if it metastasizes, its cure rate is still >95%. However, the long-term toxicity and side effects of radiotherapy and chemotherapy cannot be ignored. Iodine-125 seeds represent a low-energy radioactive source that kills tumor cells while protecting the surrounding normal tissues, and brachytherapy using iodi...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Linhao Ran Ying Liu Li Jiang Source Type: research
Indolent growth of low ‑grade myofibroblastic sarcoma of the knee with the resemblance of a benign lesion: A case report
Oncol Lett. 2024 Feb 19;27(4):163. doi: 10.3892/ol.2024.14296. eCollection 2024 Apr.ABSTRACTLow-grade myofibroblastic sarcoma (LGMS) is a rare soft-tissue malignant neoplasm originating from the stromal cells that is predominantly comprised of atypical myofibroblasts. The present study reports the case of a patient with low-grade myofibroblastic sarcoma in the soft tissue of the knee. The patient exhibited a soft, painless mass on the medial side of the left knee. During surgery, a yellow-white mass above the posterior margin of the sartorius muscle was identified. This mass, which was irregular and adherent to surrounding...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Tao Cheng Shaohua Liang Jinli Zhang Wen Wang Source Type: research
Exploring miRNA ‑target gene profiles associated with drug resistance in patients with breast cancer receiving neoadjuvant chemotherapy
Oncol Lett. 2024 Feb 16;27(4):158. doi: 10.3892/ol.2024.14291. eCollection 2024 Apr.ABSTRACTExosomal microRNAs (miRNAs) are closely related to drug resistance in patients with breast cancer (BC); however, only a few roles of the exosomal miRNA-target gene networks have been clinically implicated in drug resistance in BC. Therefore, the present study aimed to identify the differential expression of exosomal miRNAs associated with drug resistance and their target mRNAs. In vitro microarray analysis was used to verify differentially expressed miRNAs (DEMs) in drug-resistant BC. Next, tumor-derived exosomes (TDEs) were isolate...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Min Woo Kim Sol Moon Suji Lee Hyojung Lee Young Kim Joon Ye Kim Jee Ye Kim Seung Il Kim Source Type: research
