Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study
Oncol Lett. 2024 Mar 11;27(5):201. doi: 10.3892/ol.2024.14335. eCollection 2024 May.ABSTRACTThe goal of the present study was to appraise the efficacy and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin (XELOX) in patients with locally advanced colorectal cancer (CRC), as relevant data on its usage in this setting are lacking. A retrospective analysis was implemented on 100 patients with locally advanced CRC who received either neoadjuvant apatinib in combination with XELOX (N=50) or neoadjuvant XELOX alone (N=50). Radiological response and pathological complete response rates were evaluated...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Tao Zhang Xinyu Peng Gang Li Liqi Yan Aimin Zhang Xiongjie Jia Source Type: research
Development and external validation of a novel score for predicting postoperative 30 ‑day mortality in tumor craniotomy patients: A cross‑sectional diagnostic study
Oncol Lett. 2024 Mar 12;27(5):205. doi: 10.3892/ol.2024.14338. eCollection 2024 May.ABSTRACTThe identification of patients with craniotomy at high risk for postoperative 30-day mortality may contribute to achieving targeted delivery of interventions. The present study aimed to develop a personalized nomogram and scoring system for predicting the risk of postoperative 30-day mortality in such patients. In this retrospective cross-sectional study, 18,642 patients with craniotomy were stratified into a training cohort (n=7,800; year of surgery, 2012-2013) and an external validation cohort (n=10,842; year of surgery, 2014-2015...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Yufei Liu Haofei Hu Yong Han Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Fanfan Chen Weiping Li Guodong Huang Source Type: research
Clinical role of the long non ‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis
Oncol Lett. 2024 Mar 8;27(5):199. doi: 10.3892/ol.2024.14332. eCollection 2024 May.ABSTRACTThe novel long non-coding RNA, EGFR-AS1, is expressed in various types of solid tumour, and its oncogenic role has been fully identified. In the present study, several articles were screened following an electronic search of the PubMed database. In total, 8 studies were included in the present systematic review. For each analysis indicator risk ratios (RRs) with 95% confidence intervals (CIs) or hazard ratios (HRs) with standard errors and 95% CIs were estimated using Review Manager 5.3. The pooled RR of high EGFR-AS1 expression amon...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Lei Zhu Jie Zhang Hongxia Zhou Guanqi Zhang Bin Wang Haolong Qi Source Type: research
Effect of valproic acid on histone deacetylase expression in oral cancer (Review)
Oncol Lett. 2024 Mar 7;27(5):197. doi: 10.3892/ol.2024.14330. eCollection 2024 May.ABSTRACTOral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell-cycle progression, differentiation and apoptosis and their dysregulation is implicated in cancer development. HDACs are promising targets for anticancer therapy through the utilisation of HDAC inhibitors (HDACis). OSCC cells have been shown to have low levels of histone acetylation, suggesting that HDACis may produce beneficial effects in...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Ahmed S K Al-Khafaji Lydia M Wang Haidar H Alabdei Triantafillos Liloglou Source Type: research
Diagnosis and comprehensive treatment of a glucagonoma in a patient with residual intrahepatic metastases postoperatively: A case report and literature review
Oncol Lett. 2024 Mar 11;27(5):202. doi: 10.3892/ol.2024.14336. eCollection 2024 May.ABSTRACTGlucagonomas are rare neuroendocrine neoplasms of the pancreas with malignant potential. At present, their epidemiology is not entirely clear, so clinicians are not well versed, lacking any consensus on diagnosis or comprehensive treatment. The present study reports the case of a 32-year-old woman hospitalized for recurrent glossitis, perioral dermatitis and necrolytic migratory erythema (NME) of both lower limbs. Imaging studies revealed a low-density nodule (~2 cm) in the tail of the pancreas, as well as multiple space-occupying h...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Shenghui Yu Muxi Ge Cheng Zhang Lang Chen Lei Zhao Source Type: research
Association between different regional lymph node metastases of papillary thyroid carcinoma in adolescents and young adults
Oncol Lett. 2024 Mar 11;27(5):204. doi: 10.3892/ol.2024.14337. eCollection 2024 May.ABSTRACTAdolescents and young adults (AYA) describe the demographic aged between 15-39 years diagnosed with cancer. This group is particularly at risk of papillary thyroid carcinoma (PTC) with a greater severity compared with other ages. Through comparative design, the present study aimed to quantify central lymph node metastasis (CLNM) risk in AYAs. A total of 463 AYA patients with PTC and 489 patients >39 years old with PTC from Ningbo Medical Center Lihuili Hospital (Ningbo, China) were enrolled. Details such as demographic data, seru...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Lili Wang Yahua Zheng Yingpeng Ye Zhekang Jiang Jinling Lu Gaoxiang Chen Source Type: research
Gene amplification of chromatin remodeling factor < em > SMARCC2 < /em > and low protein expression of ACTL6A are unfavorable factors in ovarian high ‑grade serous carcinoma
Oncol Lett. 2024 Mar 7;27(5):196. doi: 10.3892/ol.2024.14329. eCollection 2024 May.ABSTRACTOvarian high-grade serous carcinoma (OHGSC) is the most common type of ovarian cancer worldwide. Genome sequencing has identified mutations in chromatin remodeling factors (CRFs) in gynecological cancer, such as clear cell carcinoma, endometrioid carcinoma and endometrial serous carcinoma. However, to the best of our knowledge, the association between CRFs and OHGSC remains unexplored. The present study aimed to investigate the clinicopathological and molecular characteristics of CRF dysfunction in OHGSC. CRF alterations were analyze...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Naomi Magarifuchi Takeshi Iwasaki Yoshihiro Katayama Takumi Tomonaga Miya Nakashima Fumiya Narutomi Kiyoko Kato Yoshinao Oda Source Type: research
CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle
Oncol Lett. 2024 Mar 13;27(5):206. doi: 10.3892/ol.2024.14339. eCollection 2024 May.ABSTRACTGlioblastoma (GBM) is characterized by significant heterogeneity, leading to poor survival outcomes for patients, despite the implementation of comprehensive treatment strategies. The roles of cyclin A2 (CCNA2) and NIMA related kinase 2 (NEK2) have been extensively studied in numerous cancers, but their specific functions in GBM remain to be elucidated. The present study aimed to investigate the potential molecular mechanisms of CCNA2 and NEK2 in GBM. CCNA2 and NEK2 expression and prognosis in glioma were evaluated by bioinformatics...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Hao-Yu Zhou Yi-Chang Wang Tuo Wang Wei Wu Yi-Yang Cao Bei-Chen Zhang Mao-De Wang Ping Mao Source Type: research
Multi ‑omics approach to improve patient‑tailored therapy using immune checkpoint blockade and cytokine‑induced killer cell infusion in an elderly patient with lung cancer: A case report and literature review
In conclusion, multi-omics analysis may be used to establish patient-tailored therapies to improve clinical outcomes in hard-to-treat elderly patients with metastatic NSCLC.PMID:38516684 | PMC:PMC10955685 | DOI:10.3892/ol.2024.14334 (Source: Oncology Letters)
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Yasi Xing Fangyuan Qin Lei Han Jingwen Yang Hongrui Zhang Yong Qi Shichun Tu Yaping Zhai Source Type: research
Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi ‑centre experience
Oncol Lett. 2024 Mar 8;27(5):198. doi: 10.3892/ol.2024.14331. eCollection 2024 May.ABSTRACTMetaplastic breast cancer (BC-Mp), which includes a range of epithelial and mixed epithelial-mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC-Mp focuses mainly on retrospective data for radically treated patients. Notably absent are studies dedicated to the palliative treatment of BC-Mp with distant metastases. The present retrospective study investigated treatment modalities and prognosis in a multi-centre cohort of 31 female participants diagnosed with distant metastatic BC-Mp,...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Miros ława Püsküllüoğlu Katarzyna Swiderska Aleksandra Konieczna Joanna Streb Aleksandra Grela-Wojewoda Agnieszka Rudzinska Jolanta Dobrza ńska Renata Pacholczak-Madej Anna Mucha-Malecka Micha ł Kunkiel Jerzy W Mitus Micha ł Jarząb Marek Ziobro Source Type: research
[Retracted] miR ‑885‑5p upregulation promotes colorectal cancer cell proliferation and migration by targeting suppressor of cytokine signaling
Oncol Lett. 2024 Mar 11;27(5):200. doi: 10.3892/ol.2024.14333. eCollection 2024 May.ABSTRACT[This retracts the article DOI: 10.3892/ol.2018.8645.].PMID:38516686 | PMC:PMC10955675 | DOI:10.3892/ol.2024.14333 (Source: Oncology Letters)
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Meng Su Baoli Qin Fang Liu Yuze Chen Rui Zhang Source Type: research
Effectiveness and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin for the therapy of locally advanced colorectal cancer: A retrospective study
Oncol Lett. 2024 Mar 11;27(5):201. doi: 10.3892/ol.2024.14335. eCollection 2024 May.ABSTRACTThe goal of the present study was to appraise the efficacy and safety of neoadjuvant apatinib in combination with capecitabine and oxaliplatin (XELOX) in patients with locally advanced colorectal cancer (CRC), as relevant data on its usage in this setting are lacking. A retrospective analysis was implemented on 100 patients with locally advanced CRC who received either neoadjuvant apatinib in combination with XELOX (N=50) or neoadjuvant XELOX alone (N=50). Radiological response and pathological complete response rates were evaluated...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Tao Zhang Xinyu Peng Gang Li Liqi Yan Aimin Zhang Xiongjie Jia Source Type: research
Development and external validation of a novel score for predicting postoperative 30 ‑day mortality in tumor craniotomy patients: A cross‑sectional diagnostic study
Oncol Lett. 2024 Mar 12;27(5):205. doi: 10.3892/ol.2024.14338. eCollection 2024 May.ABSTRACTThe identification of patients with craniotomy at high risk for postoperative 30-day mortality may contribute to achieving targeted delivery of interventions. The present study aimed to develop a personalized nomogram and scoring system for predicting the risk of postoperative 30-day mortality in such patients. In this retrospective cross-sectional study, 18,642 patients with craniotomy were stratified into a training cohort (n=7,800; year of surgery, 2012-2013) and an external validation cohort (n=10,842; year of surgery, 2014-2015...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Yufei Liu Haofei Hu Yong Han Zongyang Li Jihu Yang Xiejun Zhang Lei Chen Fanfan Chen Weiping Li Guodong Huang Source Type: research
Clinical role of the long non ‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis
Oncol Lett. 2024 Mar 8;27(5):199. doi: 10.3892/ol.2024.14332. eCollection 2024 May.ABSTRACTThe novel long non-coding RNA, EGFR-AS1, is expressed in various types of solid tumour, and its oncogenic role has been fully identified. In the present study, several articles were screened following an electronic search of the PubMed database. In total, 8 studies were included in the present systematic review. For each analysis indicator risk ratios (RRs) with 95% confidence intervals (CIs) or hazard ratios (HRs) with standard errors and 95% CIs were estimated using Review Manager 5.3. The pooled RR of high EGFR-AS1 expression amon...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Lei Zhu Jie Zhang Hongxia Zhou Guanqi Zhang Bin Wang Haolong Qi Source Type: research
Effect of valproic acid on histone deacetylase expression in oral cancer (Review)
Oncol Lett. 2024 Mar 7;27(5):197. doi: 10.3892/ol.2024.14330. eCollection 2024 May.ABSTRACTOral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell-cycle progression, differentiation and apoptosis and their dysregulation is implicated in cancer development. HDACs are promising targets for anticancer therapy through the utilisation of HDAC inhibitors (HDACis). OSCC cells have been shown to have low levels of histone acetylation, suggesting that HDACis may produce beneficial effects in...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Ahmed S K Al-Khafaji Lydia M Wang Haidar H Alabdei Triantafillos Liloglou Source Type: research
