Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer
Oncol Lett. 2024 Mar 14;27(5):209. doi: 10.3892/ol.2024.14342. eCollection 2024 May.ABSTRACTBreast cancer (BC) is the most common type of malignancy and the leading cause of cancer-associated mortality in women worldwide. As such, assessing the metabolic changes during human breast carcinogenesis is key for developing disease prevention methods and treatment. In the present study, non-targeted metabolomics with chemometrics based on ultra-high performance liquid chromatography-high-resolution mass spectrometry were performed to assess differences in serum metabolite patterns between patients with BC and healthy individuals...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Qinqin Zhang Rongzhao Lu Ying Wu Yong Hong Ningxia Wang Cunchuan Wang Source Type: research
Characteristics and prognostic value of gut microbiota in follicular lymphoma
Oncol Lett. 2024 Mar 13;27(5):207. doi: 10.3892/ol.2024.14340. eCollection 2024 May.ABSTRACTThe pathogenesis and progression of follicular lymphoma (FL) depends on immune evasion mechanisms. The gut microbiota has been reported to be associated with the development and outcome of several human diseases by modulating host immunity. Thus, the present study investigated the characteristics and prognostic value of the gut microbiota in FL. Fecal samples from treatment-naïve patients with FL (n=28) and healthy controls (n=18) were prospectively collected. The gut microbiota diversity and composition were examined by 16S riboso...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Zhuo-Fan Xu Danqing Zhao Chong Wei Wei Wang Yan Zhang Wei Zhang Daobin Zhou Source Type: research
Misdiagnosis of multiple myeloma as postoperative bone metastasis of rectal cancer: A case report and literature review
Oncol Lett. 2024 Mar 14;27(5):208. doi: 10.3892/ol.2024.14341. eCollection 2024 May.ABSTRACTMultiple myeloma (MM) and bone metastases are both common malignant tumors of the skeleton that share similar clinical manifestations and radiological features. The development of MM following rectal cancer surgery is relatively rare in clinical practice and is easily misdiagnosed as bone metastasis. The present study reported on a patient with MM and postoperative rectal cancer. A 65-year-old man had been diagnosed with low rectal cancer (poorly differentiated, T3N1M0) 10 years prior and underwent curative treatment at that time. D...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Yuanqi Huang Zhengquan Chen Kunming Wen Source Type: research
PYCR1 regulates TRAIL ‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors
Oncol Lett. 2024 Mar 19;27(5):216. doi: 10.3892/ol.2024.14349. eCollection 2024 May.ABSTRACTAlthough recombinant human TNF-related apoptosis-inducing ligand (TRAIL) protein exhibits antitumor activity in a number of lung and liver cancer cells and tumor-bearing animals, TRAIL resistance has substantially restricted its clinical application. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a key enzyme in the regulation of proline synthesis. PYCR1 is highly expressed in various types of malignant tumor, in which it has been implicated in 5-fluorouracil resistance. However, the possible relationship between PYCR1 and TRAIL res...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Chengcheng You Jinlan He Chunyu Cao Deqiao Sheng Lin Wang Zhixian Huang Xiaoling Zhang Changjun Yi Yingming Sun Yiling Huang Source Type: research
Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer
Oncol Lett. 2024 Mar 14;27(5):209. doi: 10.3892/ol.2024.14342. eCollection 2024 May.ABSTRACTBreast cancer (BC) is the most common type of malignancy and the leading cause of cancer-associated mortality in women worldwide. As such, assessing the metabolic changes during human breast carcinogenesis is key for developing disease prevention methods and treatment. In the present study, non-targeted metabolomics with chemometrics based on ultra-high performance liquid chromatography-high-resolution mass spectrometry were performed to assess differences in serum metabolite patterns between patients with BC and healthy individuals...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Qinqin Zhang Rongzhao Lu Ying Wu Yong Hong Ningxia Wang Cunchuan Wang Source Type: research
Characteristics and prognostic value of gut microbiota in follicular lymphoma
Oncol Lett. 2024 Mar 13;27(5):207. doi: 10.3892/ol.2024.14340. eCollection 2024 May.ABSTRACTThe pathogenesis and progression of follicular lymphoma (FL) depends on immune evasion mechanisms. The gut microbiota has been reported to be associated with the development and outcome of several human diseases by modulating host immunity. Thus, the present study investigated the characteristics and prognostic value of the gut microbiota in FL. Fecal samples from treatment-naïve patients with FL (n=28) and healthy controls (n=18) were prospectively collected. The gut microbiota diversity and composition were examined by 16S riboso...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Zhuo-Fan Xu Danqing Zhao Chong Wei Wei Wang Yan Zhang Wei Zhang Daobin Zhou Source Type: research
Misdiagnosis of multiple myeloma as postoperative bone metastasis of rectal cancer: A case report and literature review
Oncol Lett. 2024 Mar 14;27(5):208. doi: 10.3892/ol.2024.14341. eCollection 2024 May.ABSTRACTMultiple myeloma (MM) and bone metastases are both common malignant tumors of the skeleton that share similar clinical manifestations and radiological features. The development of MM following rectal cancer surgery is relatively rare in clinical practice and is easily misdiagnosed as bone metastasis. The present study reported on a patient with MM and postoperative rectal cancer. A 65-year-old man had been diagnosed with low rectal cancer (poorly differentiated, T3N1M0) 10 years prior and underwent curative treatment at that time. D...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Yuanqi Huang Zhengquan Chen Kunming Wen Source Type: research
Effect of valproic acid on histone deacetylase expression in oral cancer (Review)
Oncol Lett. 2024 Mar 7;27(5):197. doi: 10.3892/ol.2024.14330. eCollection 2024 May.ABSTRACTOral squamous cell carcinoma (OSCC) is a frequent human malignancy that demonstrates a range of genetic and epigenetic alterations. Histone deacetylases (HDACs) are key epigenetic regulators of cell-cycle progression, differentiation and apoptosis and their dysregulation is implicated in cancer development. HDACs are promising targets for anticancer therapy through the utilisation of HDAC inhibitors (HDACis). OSCC cells have been shown to have low levels of histone acetylation, suggesting that HDACis may produce beneficial effects in...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Ahmed S K Al-Khafaji Lydia M Wang Haidar H Alabdei Triantafillos Liloglou Source Type: research
Diagnosis and comprehensive treatment of a glucagonoma in a patient with residual intrahepatic metastases postoperatively: A case report and literature review
Oncol Lett. 2024 Mar 11;27(5):202. doi: 10.3892/ol.2024.14336. eCollection 2024 May.ABSTRACTGlucagonomas are rare neuroendocrine neoplasms of the pancreas with malignant potential. At present, their epidemiology is not entirely clear, so clinicians are not well versed, lacking any consensus on diagnosis or comprehensive treatment. The present study reports the case of a 32-year-old woman hospitalized for recurrent glossitis, perioral dermatitis and necrolytic migratory erythema (NME) of both lower limbs. Imaging studies revealed a low-density nodule (~2 cm) in the tail of the pancreas, as well as multiple space-occupying h...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Shenghui Yu Muxi Ge Cheng Zhang Lang Chen Lei Zhao Source Type: research
Association between different regional lymph node metastases of papillary thyroid carcinoma in adolescents and young adults
Oncol Lett. 2024 Mar 11;27(5):204. doi: 10.3892/ol.2024.14337. eCollection 2024 May.ABSTRACTAdolescents and young adults (AYA) describe the demographic aged between 15-39 years diagnosed with cancer. This group is particularly at risk of papillary thyroid carcinoma (PTC) with a greater severity compared with other ages. Through comparative design, the present study aimed to quantify central lymph node metastasis (CLNM) risk in AYAs. A total of 463 AYA patients with PTC and 489 patients >39 years old with PTC from Ningbo Medical Center Lihuili Hospital (Ningbo, China) were enrolled. Details such as demographic data, seru...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Lili Wang Yahua Zheng Yingpeng Ye Zhekang Jiang Jinling Lu Gaoxiang Chen Source Type: research
Gene amplification of chromatin remodeling factor < em > SMARCC2 < /em > and low protein expression of ACTL6A are unfavorable factors in ovarian high ‑grade serous carcinoma
Oncol Lett. 2024 Mar 7;27(5):196. doi: 10.3892/ol.2024.14329. eCollection 2024 May.ABSTRACTOvarian high-grade serous carcinoma (OHGSC) is the most common type of ovarian cancer worldwide. Genome sequencing has identified mutations in chromatin remodeling factors (CRFs) in gynecological cancer, such as clear cell carcinoma, endometrioid carcinoma and endometrial serous carcinoma. However, to the best of our knowledge, the association between CRFs and OHGSC remains unexplored. The present study aimed to investigate the clinicopathological and molecular characteristics of CRF dysfunction in OHGSC. CRF alterations were analyze...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Naomi Magarifuchi Takeshi Iwasaki Yoshihiro Katayama Takumi Tomonaga Miya Nakashima Fumiya Narutomi Kiyoko Kato Yoshinao Oda Source Type: research
CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle
Oncol Lett. 2024 Mar 13;27(5):206. doi: 10.3892/ol.2024.14339. eCollection 2024 May.ABSTRACTGlioblastoma (GBM) is characterized by significant heterogeneity, leading to poor survival outcomes for patients, despite the implementation of comprehensive treatment strategies. The roles of cyclin A2 (CCNA2) and NIMA related kinase 2 (NEK2) have been extensively studied in numerous cancers, but their specific functions in GBM remain to be elucidated. The present study aimed to investigate the potential molecular mechanisms of CCNA2 and NEK2 in GBM. CCNA2 and NEK2 expression and prognosis in glioma were evaluated by bioinformatics...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Hao-Yu Zhou Yi-Chang Wang Tuo Wang Wei Wu Yi-Yang Cao Bei-Chen Zhang Mao-De Wang Ping Mao Source Type: research
Multi ‑omics approach to improve patient‑tailored therapy using immune checkpoint blockade and cytokine‑induced killer cell infusion in an elderly patient with lung cancer: A case report and literature review
In conclusion, multi-omics analysis may be used to establish patient-tailored therapies to improve clinical outcomes in hard-to-treat elderly patients with metastatic NSCLC.PMID:38516684 | PMC:PMC10955685 | DOI:10.3892/ol.2024.14334 (Source: Oncology Letters)
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Yasi Xing Fangyuan Qin Lei Han Jingwen Yang Hongrui Zhang Yong Qi Shichun Tu Yaping Zhai Source Type: research
Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi ‑centre experience
Oncol Lett. 2024 Mar 8;27(5):198. doi: 10.3892/ol.2024.14331. eCollection 2024 May.ABSTRACTMetaplastic breast cancer (BC-Mp), which includes a range of epithelial and mixed epithelial-mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC-Mp focuses mainly on retrospective data for radically treated patients. Notably absent are studies dedicated to the palliative treatment of BC-Mp with distant metastases. The present retrospective study investigated treatment modalities and prognosis in a multi-centre cohort of 31 female participants diagnosed with distant metastatic BC-Mp,...
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Miros ława Püsküllüoğlu Katarzyna Swiderska Aleksandra Konieczna Joanna Streb Aleksandra Grela-Wojewoda Agnieszka Rudzinska Jolanta Dobrza ńska Renata Pacholczak-Madej Anna Mucha-Malecka Micha ł Kunkiel Jerzy W Mitus Micha ł Jarząb Marek Ziobro Source Type: research
[Retracted] miR ‑885‑5p upregulation promotes colorectal cancer cell proliferation and migration by targeting suppressor of cytokine signaling
Oncol Lett. 2024 Mar 11;27(5):200. doi: 10.3892/ol.2024.14333. eCollection 2024 May.ABSTRACT[This retracts the article DOI: 10.3892/ol.2018.8645.].PMID:38516686 | PMC:PMC10955675 | DOI:10.3892/ol.2024.14333 (Source: Oncology Letters)
Source: Oncology Letters - March 22, 2024 Category: Cancer & Oncology Authors: Meng Su Baoli Qin Fang Liu Yuze Chen Rui Zhang Source Type: research
