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Comparison of synthetic mammography, reconstructed from digital breast tomosynthesis, and digital mammography: evaluation of lesion conspicuity and BI-RADS assessment categories
ConclusionsSM alone showed similar interpretive performance to FFDM, confirming its potential role as an alternative to FFDM in women having tomosynthesis, with the added advantage of halving the patient ’s dose exposure. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor- α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells
ConclusionsThese studies identify functional EREs in theIKKB promoter and identifyIKKB as an ER α and NSC35446.HCl-regulated gene, and they suggest that NF-κB andIKKB, which were previously linked to antiestrogen resistance, are targets for NSC35446.HCl in reversing antiestrogen resistance. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Breast cancer in elderly women and altered clinico-pathological characteristics: a systematic review
In this study we examined clinical, histological, and biological characteristics and mortality of breast cancer in elderly women along with their changes with advancing age.MethodsWe reviewed 63 original articles published between 2006 and 2016 concerning women over 70  years with breast cancer.ResultsCompared to patients 70 –79 years, patients aged 80 and over had larger tumor size with fewer T1 (42.9% vs 57.7%, p 
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Utilization of bioimpedance spectroscopy in the prevention of chronic breast cancer-related lymphedema
ConclusionsThe results of this study support prospective surveillance utilizing BIS initiated pre-operatively with subsequent post-operative follow-up measurements for the detection of subclinical BCRL. Intervention triggered by subclinical BCRL detection with an elevated L-Dex score was associated with no cases progressing to chronic, clinically detectable BCRL even in very high-risk patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Molecular characterization and heterogeneity of circulating tumor cells in breast cancer
ConclusionsData obtained from the present study suggest that BC is a heterogeneous disease but CTCs may be detected independently of the disease characteristics in 76% of patients at any time point during the course of the disease. This relatively high CTC occurrence in BC should be considered when planning the long-term patient monitoring. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer
ConclusionsOur data presented the germline mutation status of PALB2 in Chinese breast cancer patients, suggesting that loss-of-function germline mutations of PALB2 are important in both familial and sporadic breast cancer. Clinically, these data may be helpful in genetic counseling of breast cancer patients with PALB2 germline mutation. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Impact of rheumatoid arthritis on radiation-related toxicity and cosmesis in breast cancer patients: a contemporary matched-pair analysis
ConclusionsAmong women with RA, radiation for breast cancer was well tolerated without significantly increased toxicity. Their cosmesis was generally Good to Excellent, although they might be less likely to get Excellent cosmesis compared to their matched pairs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Breast cancer screening in transgender patients: findings from the 2014 BRFSS survey
ConclusionsHigh proportions of transgender survey respondents undergo mammography screening (57.9 –66.1% within the last year, 71.9–74.4% within the last two years) in our sample, proportions comparable to non-transgender survey respondents. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Clinical pattern of primary systemic therapy and outcomes of estrogen receptor-positive, HER2-negative metastatic breast cancer: a review of a single institution
AbstractPurposeIn the management of estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer (ER+HER2 −MBC) patients, endocrine therapy (ET) is preferred to chemotherapy (CT) as a primary systemic therapy (PST) when tumor burden is not high. However, there are no definite criteria for choosing a PST, transitioning from ET to CT or using maintenance ET subsequent to CT.MethodsWe reviewed the medical records of 311 ER+HER2 −MBC patients who underwent CT from September 2002 to December 2016 and assessed their outcomes.ResultsOf the 311 patients, 178 (57%) received ET a...
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Familial associations of male breast cancer with other cancers
AbstractPurposeMale breast cancer is associated with female breast cancer in families but whether male breast cancer clusters with other discordant cancers has not been studied. As concordant male breast cancers are utterly rare, discordant associations of male breast cancer with other cancers may reveal genetic and possible environmental risk factors contributing to male breast cancer susceptibility.MethodsWe calculated relative risks (RRs) for male breast cancer in families with discordant cancers, and conversely, for discordant cancers in families of male breast cancer patients, based on 15.7 million individuals in the ...
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Cardiac toxicities of lapatinib in patients with breast cancer and other HER2-positive cancers: a meta-analysis
ConclusionThe overall incidence of lapatinib-induced cardiac toxicity was relatively low based on an indirect comparison with trastuzumab. However, careful monitoring of cardiac toxicity is still needed when patients are treated with lapatinib because the related risk factors have not been clearly identified. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Different prognosis of young breast cancer patients in their 20s and 30s depending on subtype: a nationwide study from the Korean Breast Cancer Society
AbstractPurposeNumerous studies have demonstrated that breast cancer in young women (BCY) has unfavorable prognostic features and more unfavorable subtypes. However, few studies have evaluated the effect of subtype disparities on breast cancer prognosis by age, especially for BCY. We analyzed breast cancer mortality stratified by tumor subtype according to age among patients younger than 50  years.MethodsData from the Korean Breast Cancer Society Registry for patients diagnosed with invasive breast cancer when aged less than 50  years between 2003 and 2010 were reviewed retrospectively.ResultsWe identified 30,793...
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Increased risk of arterial thromboembolism in older men with breast cancer
ConclusionsWe provide population-based evidence that male breast cancer patients have a substantially elevated risk of ATE in the first year following a cancer diagnosis compared with matched controls. Care providers should consider this heightened risk when evaluating cardiovascular health in men with a recent breast cancer diagnosis. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Association between mammographic density and pregnancies relative to age and BMI: a breast cancer case-only analysis
ConclusionsThe effect of pregnancies on mammographic density does not appear to become apparent before the age of menopause. The mechanism that drives the effect of pregnancies on mammographic density appears to be counter-regulated by other influences on mammographic density in younger patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Estrogen receptor quantitative measures and breast cancer survival
ConclusionsEstrogen receptor percent positive staining is not independently related to breast cancer survival after adjustment for other survival-related factors. ER intensity, in contrast, demonstrates promise for prognostic utility. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

BMI change and abdominal circumference are risk factors for breast cancer, even in Asian women
This study evaluated obesity through body mass index (BMI) at age 18–20 years (BMI18–20y), BMI at research entry (entry BMI), change of BMI from age 18–20 to research entry (ΔBMI), abdominal circumference at research entry (AC), and HbA1c [N] at research entry (HbA1c). We used a multivariate Cox proportional hazard model to evaluate hazard ratios (HRs) and 95% confidence intervals (95% CIs).ResultsOf the 30,109 women, 325 were initially diagnosed with breast cancer over 131,657 person-years. Postmenopausal women whose BMI increased ≥+5.0 were significantly more likely to develop breast cance...
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Impact of repeat HER2 testing after initial equivocal HER2 FISH results using 2013 ASCO/CAP guidelines
AbstractPurposeThe updated 2013 American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 (HER2) testing have made some major changes in HER2 fluorescence in situ hybridization (FISH) interpretation criteria with additional FISH equivocal cases. Repeat HER2 testing is recommended after initial HER2 FISH equivocal results; however, little is known about its impact on final HER2 status. The aim of this study is to investigate whether reflex test clarifies HER2 status, and to characterize clinicopathological features of the newly defined HER2 ...
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel
ConclusionThe contribution of the known cancer susceptibility genes to the burden of inherited breast/ovarian cancer predisposition in non-Jews in Israel is modest. Other genes or molecular mechanisms account for the familial breast/ovarian cancer clustering in this population. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Utilization of bioimpedance spectroscopy in the prevention of chronic breast cancer-related lymphedema
Discussion section,  the second paragraph, fifth sentence was published incorrectly as “Patients with an L-Dex increase of ≥ 5.5 undergo…sleeve for 4 weeks”. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2017 Category: Cancer & Oncology Source Type: research

Impact of microinvasion on breast cancer mortality in women with ductal carcinoma in situ
AbstractBackgroundDuctal carcinoma in situ (DCIS) is a neoplastic proliferation of epithelial cells which is confined within the basement membrane of the mammary ductal –lobular system. It is of interest to determine to what extent the potential to metastasize increases for DCIS patients when the basement membrane is breached (i.e. microinvasion is present).MethodsWe retrieved the records of 525,395 women who had either first primary DCIS or small ( ≤ 2.0 cm) node-negative invasive breast cancer in the Surveillance, Epidemiology and End Results (SEER) registries database (1990–2013). For each patie...
Source: Breast Cancer Research and Treatment - November 8, 2017 Category: Cancer & Oncology Source Type: research

Characteristics and outcomes of breast cancer patients enrolled in the National Cancer Institute Cancer Therapy Evaluation Program sponsored phase I clinical trials
We report an analysis of demographic variables, rates of response to treatment, grade 4 toxicities, and treatment-related deaths.ResultsDe-identified data from 8087 patients were analyzed, with 1,376 having a diagnosis of BC. The median time from initial cancer diagnosis to enrollment in a CTEP-sponsored phase I clinical trial was 614  days for all patients. Breast cancer patients were enrolled on average 790 days after initial diagnosis, while non-BC patients had a median enrollment time of 582 days (p 
Source: Breast Cancer Research and Treatment - November 8, 2017 Category: Cancer & Oncology Source Type: research

BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylation
ConclusionsBRCA1 deficiency was recurrent in early-onset triple-negative breast cancer in Brazilian patients and associated with improved survival. With the new treatment modalities being investigated, including poly (ADP-ribose)-polymerase (PARP) inhibitor therapy, our results suggest that a significant proportion of young women with this subtype of tumor might benefit from PARP inhibitor treatment, which warrants further investigation. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2017 Category: Cancer & Oncology Source Type: research

Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer
ConclusionPI3K pathway activation is associated with resistance to lapatinib and trastuzumab in breast cancers, without chemotherapy. Further studies are warranted to investigate how to use these biomarkers to identify upfront patients who may respond to anti-HER2 alone, without chemotherapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2017 Category: Cancer & Oncology Source Type: research

Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial
ConclusionsVitamin D supplementation can decrease circulating 27HC of breast cancer patients, likely by CYP27A1 inhibition. This suggests a new and additional modality by which vitamin D can inhibit ER+ breast cancer growth, though a larger study is needed for verification. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2017 Category: Cancer & Oncology Source Type: research

Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers
AbstractPurposePrevious research assessing the impact of pregnancy and age at first pregnancy on breast cancer risk inBRCA1 andBRCA2 mutation carriers has produced conflicting results, with some studies showing an increased risk following early first pregnancy in contrast to the reduced risk in the general population of women. The present study addresses these inconsistencies.MethodsFemaleBRCA1 andBRCA2 carriers from North West England were assessed for breast cancer incidence prior to 50  years of age comparing those with an early first full-term pregnancy (
Source: Breast Cancer Research and Treatment - November 7, 2017 Category: Cancer & Oncology Source Type: research

Breast cancer-related paraneoplastic neurologic disease
ConclusionsPND symptoms often presented prior to BC diagnosis, with the BC biologic subtype characteristics typical of the general BC population. BC diagnoses were often made at younger ages than that of the general BC population and with later-stage disease. Roughly 75% of patients benefited from immunotherapy. These data provide helpful information to providers treating this population of patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2017 Category: Cancer & Oncology Source Type: research

Patient-reported factors associated with adherence to adjuvant endocrine therapy after breast cancer: an integrative review
ConclusionsAn increasing number of studies have focused on identifying the patient-reported factors that influence AET adherence and persistence. This review highlights important personal, social, and structural factors that act as facilitators and barriers in adhering to and persisting with long-term AET. Acknowledging and addressing these factors is key to providing women with the care needed to improve suboptimal adherence and persistence. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 6, 2017 Category: Cancer & Oncology Source Type: research

The effect of an aerobic exercise bout 24  h prior to each doxorubicin treatment for breast cancer on markers of cardiotoxicity and treatment symptoms: a RCT
This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms.MethodsTwenty-four women with early stage breast cancer were randomly assigned to perform a 30-min, vigorous-intensity treadmill bout 24  h prior to each of four doxorubicin-containing chemotherapy treatments or to usual care. Established echocardiographic and circulating biomarkers of subclinical cardiotoxicity, as well as blood pressure and body weight were measured before the first and 7–14 days after the last treatment. The R otterd...
Source: Breast Cancer Research and Treatment - November 6, 2017 Category: Cancer & Oncology Source Type: research

Acknowledgement of reviewers 2016
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 6, 2017 Category: Cancer & Oncology Source Type: research

Efficacy and safety in older patient subsets in studies of endocrine monotherapy versus combination therapy in patients with HR+/HER2 − advanced breast cancer: a review
AbstractPurposeProspective information regarding the tolerability and efficacy of endocrine therapy (ET) alone and in combination with targeted agents in older patients in the metastatic setting is limited. This review summarizes available trial data in this population.MethodsWe searched PubMed for Phase 2 or 3 trials with age-stratified patient cohorts ( ≥ 65 vs. 
Source: Breast Cancer Research and Treatment - November 4, 2017 Category: Cancer & Oncology Source Type: research

Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain
ConclusionHigh-dosen− 3 PUFA supplementation is feasible and well tolerated when administered with AIs. Additional studies are needed to evaluate efficacy in prevention of joint symptoms. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 3, 2017 Category: Cancer & Oncology Source Type: research

Safety of fertility preservation in breast cancer patients in a register-based matched cohort study
ConclusionEvidence was not found that fertility preservation, with or without hormonal stimulation, was associated with an increased risk of breast cancer recurrence. The high coverage rate of this population-based study supports the safe practice of fertility preservation in young women with breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 2, 2017 Category: Cancer & Oncology Source Type: research

Long-term peripheral neuropathy symptoms in breast cancer survivors
AbstractPurposePeripheral neuropathy (PN) is a common and distressing complication from chemotherapy. Symptoms often, but not always, improve with time. The prevalence of long-term PN symptoms in breast cancer survivors is not well known. We sought to explore PN symptoms and associated risk factors among breast cancer survivors at least 2  years out from diagnosis.MethodsWe performed a cross-sectional retrospective study investigating the prevalence of patient-reported numbness, tingling, and anesthesia symptoms as a surrogate for PN in breast cancer survivors. We included patients with stage 0 –III breast cance...
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

Clinical implementation of synthesized mammography with digital breast tomosynthesis in a routine clinical practice
This study evaluated the implementation of SM  + DBT in routine screening practice in terms of recall rates, cancer detection rates (CDR), % of minimal cancers, % of node-positive cancers, and positive predictive values (PPV).Materials and methodsA multivariate retrospective institutional analysis was performed on 31,979 women who obtained screening mammography (10/2013 –12/2015) with cohorts divided by modality (SM + DBT, FFDM + DBT, and FFDM). We adjusted for comparison mammograms, age, breast density, and the interpreting radiologist. Recall type was analyzed for differences (foc...
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

Meta-analysis of tumour burden in pre-operative axillary ultrasound positive and negative breast cancer patients
ConclusionsPre-operative ultrasound positive patients have significantly higher axillary burden. However, nearly half do fit the criteria of low axillary burden and could be considered for omission of ANC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Meta-analysis of tumour burden in pre-operative axillary ultrasound positive and negative breast cancer patients
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

Reply to Kopans
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

CD56+ immune cell infiltration and MICA are decreased in breast lobules with fibrocystic changes
AbstractPurposeWhile the role of natural killer (NK) cells in breast cancer therapy has been investigated, little information is known about NK cell function and presence in nonmalignant and premalignant breast tissue. Here, we investigate and quantify NK cell marker CD56 and activating ligand MICA in breast tissue with benign breast disease.MethodsSerial tissue sections from 88 subjects, 44 with benign breast disease (BBD) who remained cancer-free, and 44 with BBD who later developed cancer, were stained with H&E, anti-MICA, and anti-CD56. Up to ten representative lobules were identified on each section. Using digital...
Source: Breast Cancer Research and Treatment - November 1, 2017 Category: Cancer & Oncology Source Type: research

Elevated S100A8 protein expression in breast cancer cells and breast tumor stroma is prognostic of poor disease outcome
ConclusionsElevated breast cancer cell and stromal S1008 protein expression are significant indicators of poorer outcomes in early stage breast cancer patients. Evaluation of S100A8 protein expression may provide additional prognostic information beyond traditional breast cancer prognostic biomarkers. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

A small-molecule inhibitor of SMAD3 attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells
ConclusionsThis study indicates that the TGF β-SMAD3 pathway plays an important role in the induction and maintenance of resistance to anti-HER2 drugs. Thus, SMAD3 is a potential therapeutic target that can inhibit resistance and restore sensitivity to anti-HER2 drugs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients
ConclusionsThe Jagged1-Notch pathway showed elevated expression in AI-resistant breast cancer cells, resulting in macrophage differentiation towards M2 TAMs and there contributing to the acquisition of AI resistance. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Breast cancer neoplastic seeding in the setting of image-guided needle biopsies of the breast
ConclusionHigh-grade, triple-negative breast cancers and multiple-insertion, non-coaxial biopsies may be risk factors for NS. NS should be suspected on the basis of the superficial and linear pattern of disease progression in these patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

21-Gene recurrence score and locoregional recurrence in lymph node-negative, estrogen receptor-positive breast cancer
AbstractBackground/purposeThe 21-gene recurrence score (RS) assay evaluates the likelihood of distant recurrence and benefit of chemotherapy in lymph node-negative, estrogen receptor (ER)-positive, HER2-negative breast cancer patients. The RS categories are associated with the risk of locoregional recurrence (LRR) in some, but not all studies.MethodsWe reviewed the institutional database to identify consecutive female patients with node-negative, ER+/HER2 − breast carcinoma tested for the 21-gene RS assay and treated at our center from 2008 to 2013. We collected data on clinicopathologic features, treatment, and outc...
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Hereditary diffuse gastric cancer and lynch syndromes in a BRCA1/2 negative breast cancer patient
DiscussionClinical manifestations, genetics, and management of both syndromes are reviewed, including prophylactic surgery and screening for unaffected family members. Management challenges for a mutation carrier with advanced breast cancer are discussed. Our case supports the clinical utility of additional multi-gene panel testing for breast cancer patients who do not have a pathogenic mutation in BRCA1/2 genes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Medical costs of treating breast cancer among younger Medicaid beneficiaries by stage at diagnosis
ConclusionsYounger breast cancer patients not only had a higher prevalence of late-stage cancer than older women, but also had higher within-stage excess costs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Impact of tissue-based genomic profiling on clinical decision making in the management of patients with metastatic breast cancer at academic centers
ConclusionsTumor genomic profiling affected clinical management in a minority of patients with metastatic breast cancer, thus these data do not support the routine use of genomic profiling outside of a clinical trial. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

A functional BRCA1 coding sequence genetic variant contributes to prognosis of triple-negative breast cancer, especially after radiotherapy
ConclusionsOur findings demonstrate that the functional  BRCA1 genetic variant contributes to prognosis of TNBC. Our study also highlights the clinical potential of this polymorphism in the screening of high-risk TNBC patients for recurrence and the possibility of patient-tailored decisions especially during radiotherapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Analysis of molecular subtypes for the increased HER2 equivocal cases caused by application of the updated 2013 ASCO/CAP HER2 testing guidelines in breast cancer
AbstractPurposeAccurate testing of the status of human epidermal growth factor receptor type 2 (HER2) is a prerequisite for HER2-directed therapy. The American Society of Clinical Oncology (ASCO) and the College of American Pathologists (CAP) published joint guideline recommendations for HER2 testing in breast cancer in 2007 and it was updated in 2013. We compared the HER2 gene amplification status based on these two guidelines and analyzed the molecular characteristics of the equivocal cases.Patients and methodsA total of 1894 patient samples were analyzed for both immunohistochemistry (IHC) and fluorescence in situ hybri...
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Letter to the editor: In response to “influence of clinical, societal, and treatment variables on racial difference in ER-/PR- breast cancer survival” by Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, Simon MS
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research

Trends in incidence and tumour grade in screen-detected ductal carcinoma in situ and invasive breast cancer
ConclusionsScreening mammography detects mostly high-grade DCIS and low- or intermediate-grade invasive cancers. The grade distribution as well as the CDR in the years after the introduction of FFDM remained stable compared to the era of SFM screening. By diagnosing and treating high-grade DCIS, which otherwise may develop into high-grade invasive carcinoma, our findings provide new evidence for the beneficial value of screening mammography programmes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 17, 2017 Category: Cancer & Oncology Source Type: research