HER2+ and triple-negative phenotypes in invasive lobular carcinoma might have different specific biological features
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 18, 2019 Category: Cancer & Oncology Source Type: research

Effects of tea consumption and the interactions with lipids on breast cancer survival
ConclusionsOur findings suggested that regularly drinking all teas (mainly green tea) except oolong after diagnosis was beneficial to breast cancer survival, particularly for women with normal lipids, while oolong tea may have an impaired effect. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 16, 2019 Category: Cancer & Oncology Source Type: research

Clinical benefit, toxicity and cost of metastatic breast cancer therapies: systematic review and meta-analysis
ConclusionsIn this era of increasing choices of MBC therapeutic agents and no superior approach to choosing a treatment regimen, the ability to compare multiple therapies based on survival, toxicity and cost would enable treating physicians to optimize therapeutic choices for patients. For investigators, it can point them in research directions that were previously non-obvious and for guideline designers, enable them to efficiently review the MBC clinical trial literature and visualize how regimens compare in the key dimensions of clinical benefit, toxicity, and cost. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 14, 2019 Category: Cancer & Oncology Source Type: research

Impact of long-term lipid-lowering therapy on clinical outcomes in breast cancer
This study evaluates the impact of duration of statin use on breast cancer patient outcomes.MethodsThis is a single-institution, retrospective cohort, examining the impact of statin use on the outcomes of 1523 women diagnosed with operable breast cancer between1995 and 2015. Clinical variables were compared using Student ’st test, Fisher ’s exact and Chi square tests. Overall (OS) and disease-free (DFS) survival were performed using Kaplan–Meier and Cox-Proportional Hazard (Cox-PH) analysis in the statistical softwareR.ResultsPatients were grouped by duration of statin use: never-statin user [N] (n&thinsp...
Source: Breast Cancer Research and Treatment - May 13, 2019 Category: Cancer & Oncology Source Type: research

Global prevalence of depression among breast cancer patients: a systematic review and meta-analysis
ConclusionsRegarding the high prevalence of depression in patients with breast cancer, it is vital to carry out screening within standard time periods and offer the necessary emotional support. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 13, 2019 Category: Cancer & Oncology Source Type: research

De-escalation of bone-modifying agents in patients with bone metastases from breast cancer: a systematic review and meta-analysis
ConclusionsThese data are supportive of de-escalation of zoledronate from onset for patients with bone metastases from breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 11, 2019 Category: Cancer & Oncology Source Type: research

Prospective evaluation of finger two-point discrimination and carpal tunnel syndrome among women with breast cancer receiving adjuvant aromatase inhibitor therapy
AbstractPurposeAromatase inhibitors (AIs) are associated with musculoskeletal symptoms and risk of developing carpal tunnel syndrome (CTS), which can impair quality of life and prompt treatment discontinuation. The incidence of CTS and clinical utility of diagnostic tests such as 2-point discrimination (2-PD) have not been prospectively examined among women receiving AIs.MethodsPostmenopausal women with stage 0-III hormone receptor-positive breast cancer who were enrolled in a randomized clinical trial investigating adjuvant AIs (Exemestane and Letrozole Pharmacogenetics, ELPh) underwent prospective evaluation of 2-PD with...
Source: Breast Cancer Research and Treatment - May 11, 2019 Category: Cancer & Oncology Source Type: research

Patterns of adjuvant care and outcomes of elderly women with stage I breast cancer after breast-conserving surgery: a population-based analysis
AbstractPurposeRandomized trials studying endocrine therapy (ET) with and without radiation therapy (RT) following breast-conserving surgery (BCS) have detected differences in local recurrence (LR) but not survival among elderly women with hormone receptor positive stage I breast cancer (BC). We assembled a population-based cohort of such women to examine the use and outcomes associated with or without the administration of adjuvant radiotherapy (RT) or ET.MethodsWomen aged  ≥ 65 years with stage I BC treated with BCS in Ontario between 2010 and 2016, their treatments and outcomes were ascertained usi...
Source: Breast Cancer Research and Treatment - May 10, 2019 Category: Cancer & Oncology Source Type: research

Microinvasion: could it be sufficient diagnostic criteria for the optimal treatment decision?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 9, 2019 Category: Cancer & Oncology Source Type: research

Adult weight gain accelerates the onset of breast cancer
The objective of this study was to investigate whether weight gain from early- to mid-adulthood influenced the timing of breast cancer onset.MethodsIncrease in body mass index (BMI) from lowest adult BMI to BMI at diagnosis and age at which these events occurred were calculated from breast cancer survivors enrolled in a weight loss trial (n = 660). Quartiles (Q) of the average increase in BMI were determined and associations between weight gain and age at disease onset were analyzed using analysis of covariance and spline regression models.ResultsA significant linear trend was observed across the quartiles of...
Source: Breast Cancer Research and Treatment - May 9, 2019 Category: Cancer & Oncology Source Type: research

T-bet + lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer
This study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as  ≥ 30 per 6.25 × 10−3 mm2.ResultsOf the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated with CD8 expression (p  
Source: Breast Cancer Research and Treatment - May 8, 2019 Category: Cancer & Oncology Source Type: research

Weekly carboplatin plus neoadjuvant anthracycline-taxane-based regimen in early triple-negative breast cancer: a prospective phase II trial by the Breast Cancer Task Force of the Belgian Society of Medical Oncology (BSMO)
ConclusionThe addition ofweekly carboplatin to neoadjuvant paclitaxel and dd EC leads to a pCR rate comparable to prior studies (54%). However, hematological toxicity and febrile neutropenia rate was unexpectedly high. Future investigations could focus on reversing the sequence, which may lead to better hematological tolerability. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 8, 2019 Category: Cancer & Oncology Source Type: research

Surrogate threshold effect based on a meta-analysis for the predictive value of progression-free survival for overall survival in hormone receptor-positive, HER2-negative metastatic breast cancer
ConclusionsBased on the derived STE, it is possible to draw conclusions on a significant effect in OS for a hypothetical trial demonstrating an upper confidence limit of HRPFS 
Source: Breast Cancer Research and Treatment - May 7, 2019 Category: Cancer & Oncology Source Type: research

Prediction of axillary pathologic response with breast pathologic complete response after neoadjuvant chemotherapy
AbstractPurposeMany breast cancer patients receive sentinel lymph node biopsy after neoadjuvant chemotherapy (NAC). We evaluated the axillary pathologic complete response (pCR) in relation to achievement of breast pCR.MethodsWe evaluated 1044 patients who were diagnosed with invasive breast cancer and were treated with NAC followed by curative surgery at the Samsung Medical Center between January 2008 and December 2016. The pathologic node-positive rates in breast pCR patients were compared for different breast cancer subtypes and clinical nodal stages.ResultsAxillary pCR was achieved in 51.9% of the patients after NAC. In...
Source: Breast Cancer Research and Treatment - May 7, 2019 Category: Cancer & Oncology Source Type: research

Management of toxicities associated with targeted therapies for HR-positive metastatic breast cancer: a multidisciplinary approach is the key to success
ConclusionsBased on the available evidence and current guidelines, we propose a series of practical recommendations for multidisciplinary clinical management of the various toxicities associated with the addition of targeted agents to endocrine therapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 7, 2019 Category: Cancer & Oncology Source Type: research

Intra-arterial Mitomycin C infusion in a large cohort of advanced liver metastatic breast cancer patients: safety, efficacy and factors influencing survival
ConclusionMMC infusion is safe and effective in advanced LMBC patients. An increased number of prior therapies, a higher liver tumour burden and elevated levels of bilirubin and ALT were associated with a worse OS. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 7, 2019 Category: Cancer & Oncology Source Type: research

Clinical and analytical validation of Ki-67 in 9069 patients from IBCSG VIII  + IX, BIG1-98 and GeparTrio trial: systematic modulation of interobserver variance in a comprehensive in silico ring trial
ConclusionsOur study shows that Ki-67 is a continuous marker which is extremely robust to pathologist variation. Even if only 50% of variance is attributable to true Ki-67-based proliferation (ICC  = 0.5), this information is sufficient to obtain statistically significant differences in clinical cohorts. This stable performance explains the observation that many Ki-67 studies achieve significant results despite relevant interobserver variance and points to a high clinical validity of this biomarker. For clinical decisions based on analysis of individual patient data, ongoing efforts to further reduce interobs...
Source: Breast Cancer Research and Treatment - May 7, 2019 Category: Cancer & Oncology Source Type: research

Elevated serum levels of sialyl Lewis X (sLe X ) and inflammatory mediators in patients with breast cancer
AbstractPurposeThe carbohydrate sialyl LewisX (sLeX) mediates cell adhesion, is critical in the normal function of immune cells, and is frequently over-expressed on cancer cells. We assessed the association, differential levels, and prognostic value of sLeX and inflammatory cytokines/chemokines in breast cancer sera.MethodsWe retrospectively measured sLeX and a panel of cytokines/chemokines in the sera of 26 non-invasive ductal carcinoma in situ (DCIS), 154 invasive non-metastatic breast cancer (non-MBC), 63 metastatic breast cancer (MBC) patients, and 43 healthy controls. Differences in sLeX and inflammatory cytokines amo...
Source: Breast Cancer Research and Treatment - May 3, 2019 Category: Cancer & Oncology Source Type: research

Efficacy of a web-based women ’s health survivorship care plan for young breast cancer survivors: a randomized controlled trial
ConclusionsIn young breast cancer survivors, a novel, web-based SCP did not result in more change in the primary outcome of improvement in at least one of the four targeted women ’s health issues, than the attention control condition. The intervention was associated with improved infertility concerns, supporting efficacy of disseminating accessible, evidence-based women’s health information to this population. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 3, 2019 Category: Cancer & Oncology Source Type: research

Noncompliance with palliative systemic therapy in patients with distant metastatic breast cancer: a blind spot for oncologists?
AbstractPurposeThe goal of our study was to provide a general overview of noncompliance with palliative systemic therapy in distant metastatic breast cancer (MBC).MethodsWe analyzed an unselected cohort of 339 patients who were diagnosed with MBC over a 22-year period (1990 –2011, age restriction: ≥ 85 years old).ResultsForty patients (11.8%) rejected the offered or recommended systemic therapy (age distribution of this noncompliance subgroup: ≤60 years at MBC diagnosis: 7.9%; 60–70 years: 13.2%; >  70 years: 15.6%). The rate of noncompliance was equally ...
Source: Breast Cancer Research and Treatment - May 2, 2019 Category: Cancer & Oncology Source Type: research

The influence of neoadjuvant chemotherapy on complications of immediate DIEP flap breast reconstructions
ConclusionsThis study demonstrated similar complication rates for patients with and without neoadjuvant chemotherapy prior to immediate breast reconstruction, indicating that it is safe to perform an immediate DIEP flap breast reconstruction after neoadjuvant chemotherapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 27, 2019 Category: Cancer & Oncology Source Type: research

Dose intensity in anthracycline-based chemotherapy for metastatic breast cancer: mature results of the randomised clinical trial ANZ 9311
ConclusionFor women with metastatic breast cancer, disease progression, survival or quality of life were no better with high-dose intensity compared to standard dose EC chemotherapy.Australian Clinical Trials Registry registration number ACTRN12605000478617. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 26, 2019 Category: Cancer & Oncology Source Type: research

Racial disparities in surveillance mammography among older breast cancer survivors
AbstractBackgroundDespite lower incidence rates among black women and a national decline in breast cancer (BC) deaths, there is a widening gap in BC mortality rates between black and white women in the United States. A previous study evaluating data from 1992 to 1999 found a racial disparity in the receipt of surveillance mammography. We sought to evaluate whether this disparity persists between black and white women diagnosed with BC between 2000 and 2011.MethodsUsing the SEER-Medicare registry, we conducted an analysis of women ≥ 66 years diagnosed with early-stage (0–III) BC between 2000 and 2011 wh...
Source: Breast Cancer Research and Treatment - April 26, 2019 Category: Cancer & Oncology Source Type: research

Shared-patient physician networks and their impact on the uptake of genomic testing in breast cancer
ConclusionsPeer connectedness to an early-adopting physician predicts ODX adoption in both physician-level and patient-level analyses. Provider networks may provide a potent and modifiable means to modulate the diffusion of emerging medical technologies. Efforts to increase testing, where appropriate, may benefit from peer-to-peer-based connection strategies. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 26, 2019 Category: Cancer & Oncology Source Type: research

Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients
ConclusionsThe impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2( –) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 26, 2019 Category: Cancer & Oncology Source Type: research

Evolution in practice patterns of axillary management following mastectomy in patients with 1 –2 positive sentinel nodes
This study aimed to describe treatment patterns of patients with positive SLNs who undergo mastectomy using a large population-based database.MethodsThe NCDB was queried for cT1 –2N0 breast cancer patients treated with mastectomy between 2006 and 2014 who had 1-2 positive SLNs. Patients receiving neoadjuvant chemotherapy were excluded. Axillary management included SLN dissection (SLND) alone, axillary lymph node dissection (ALND), post-mastectomy radiation (PMRT) alone, a nd ALND + PMRT. Trends of axillary management and patient characteristics were examined.ResultsAmong 12,190 patients who met study cr...
Source: Breast Cancer Research and Treatment - April 25, 2019 Category: Cancer & Oncology Source Type: research

The impact of communication style on patient satisfaction
ConclusionsPatients who were physically healthy and employed were generally more satisfied with their care. The similarity in communication styles of patients and providers had a greater impact on patient satisfaction for patients who were less physically healthy and not employed. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 25, 2019 Category: Cancer & Oncology Source Type: research

Classifying sarcopenia: using median value or cut-off values?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 25, 2019 Category: Cancer & Oncology Source Type: research

Post-mastectomy immediate breast reconstruction is oncologically safe in well-selected T4 locally advanced breast cancer: a large population-based study and matched case –control analysis
ConclusionsIBR is oncologically safe in well-selected T4 LABC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2019 Category: Cancer & Oncology Source Type: research

Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study
ConclusionsWe showed that a history of breast cancer has a negative effect on childbirth among young premenopausal women in Korea. Breast cancer survivors should be aware that they have a higher risk for preterm labor and are less likely to have a full-term delivery than women without a history of breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2019 Category: Cancer & Oncology Source Type: research

Examining the cost-effectiveness of baseline left ventricular function assessment among breast cancer patients undergoing anthracycline-based therapy
ConclusionsAge, preexisting cardiac risk factors and coronary artery disease did not predict a baseline abnormal LVEF. While the prevalence of an abnormal baseline LVEF is low in patients with breast cancer, our results suggest that cardiac screening prior to anthracycline is cost-effective. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2019 Category: Cancer & Oncology Source Type: research

Breast desmoid tumor management in France: toward a new strategy
ConclusionThis study supports an initial nonsurgical approach to BDTs followed by surgery based on tumor growth in select cases, which is consistent with current ESMO recommendations. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 23, 2019 Category: Cancer & Oncology Source Type: research

Examination and prognostic implications of the unique microenvironment of breast cancer brain metastases
This study reports on four histological biomarkers, gliosis, immune infiltrate, hemorrhage, necrosis, and their prognostic significance in BCBM.MethodsA biobank of 203 human tissues from patients who underwent craniotomy for BCBM was created across four academic institutions. Degree of gliosis, immune infiltrate, hemorrhage, and necrosis were identified and scored via representative H&E stain (0 –3+). Overall survival (OS) was estimated using the Kaplan–Meier method. Cox proportional hazards regression evaluated prognostic value of the biomarkers in the context of standard clinical characteristics.ResultsBC...
Source: Breast Cancer Research and Treatment - April 23, 2019 Category: Cancer & Oncology Source Type: research

Oral or intravenous vinorelbine plus capecitabine in heavily pretreated HER2 negative metastatic breast cancer; similar effect or quality of life?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 23, 2019 Category: Cancer & Oncology Source Type: research

Comparing long-term local recurrence rates of surgical and non-surgical management of close anterior margins in breast conserving surgery
ConclusionsLocal recurrence rates are acceptable and similar in both the surgically and non-surgically managed groups. Non-surgical management of close anterior margins appears oncologically safe when combined with appropriate adjuvant therapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 22, 2019 Category: Cancer & Oncology Source Type: research

Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa
ConclusionsWe successfully identified distinct groups of IBC and non-IBC cases. The reliability of IBC diagnosis would benefit from expert review of standardized medical photographs and associated clinical information. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 22, 2019 Category: Cancer & Oncology Source Type: research

Does every woman presenting with malignant calcifications require a post lumpectomy mammogram?
ConclusionPLM plays an important role in the evaluation of patients undergoing breast conservation for breast cancer presenting with microcalcifications. Residual malignancy was detected on positive PLM in 6% of patients with negative margins. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 20, 2019 Category: Cancer & Oncology Source Type: research

Regulation of AKT phosphorylation by GSK3 β and PTEN to control chemoresistance in breast cancer
ConclusionsAKT phosphorylation mediated by GSK3 β and PTEN were correlated with cell viability, migration and apoptosis, which may promote chemoresistance in breast cancer. Furthermore, GSK3β can regulate cell viability through the PTEN/PI3K/AKT signaling pathway and induce chemoresistance, serving as a valuable molecular strategy for breast ca ncer therapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 20, 2019 Category: Cancer & Oncology Source Type: research

A novel RNA aptamer identifies plasma membrane ATP synthase beta subunit as an early marker and therapeutic target in aggressive cancer
AbstractPurposePrimary breast and prostate cancers can be cured, but metastatic disease cannot. Identifying cell factors that predict metastatic potential could guide both prognosis and treatment.MethodsWe used Cell-SELEX to screen an RNA aptamer library for differential binding to prostate cancer cell lines with high vs. low metastatic potential. Mass spectroscopy, immunoblot, and immunohistochemistry were used to identify and validate aptamer targets. Aptamer properties were tested in vitro, in xenograft models, and in clinical biopsies. Gene expression datasets were queried for target associations in cancer.ResultsWe id...
Source: Breast Cancer Research and Treatment - April 20, 2019 Category: Cancer & Oncology Source Type: research

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies
ConclusionsHistory of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 19, 2019 Category: Cancer & Oncology Source Type: research

Local –regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial)
ConclusionLRR in this select group of early-stage patients with HER2-positive disease receiving effective anti-HER2 therapy is extremely low. If  confirmed in additional studies, future investigational efforts should focus on de-escalating local therapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 19, 2019 Category: Cancer & Oncology Source Type: research

Higher ER load is not associated with better outcome in stage 1 –3 breast cancer: a descriptive overview of quantitative HR analysis in operable breast cancer
ConclusionsThere is no clear evidence for using quantitatively assessed ER and PR as prognostic nor predictive marker in patients with stage 1 –3 breast cancer. We recommend only using a qualitative HR status in future guidelines and treatment considerations. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 17, 2019 Category: Cancer & Oncology Source Type: research

Systematic review of economic evaluations of exercise and physiotherapy for patients treated for breast cancer
ConclusionsThe evidence surrounding the cost-effectiveness of exercise and physiotherapy interventions for the treatment of breast cancer remains sparse with contrasting conclusions. Future research should particularly aim to broaden the evidence base by disentangling the contributing effects of frequency, intensity, time and type of exercise and physiotherapy interventions on cost-effectiveness outcomes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 17, 2019 Category: Cancer & Oncology Source Type: research

Impact of invasive lobular carcinoma on long-term outcomes in Mexican breast cancer patients
AbstractPurposeThe aim of this study was to compare the difference in disease-free survival (DFS) and overall survival (OS) between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) in our Hispanic population with breast cancer (BC).MethodsWe retrospectively analyzed a database of 4533 non-metastatic BC patients treated for BC at the National Cancer Institute in Mexico (INCan) between 2006 and 2016. We compared clinical characteristics, treatment and survival between women with invasive ductal and invasive lobular BC. We evaluated differences between survival curves with the log-rank test and used Cox &r...
Source: Breast Cancer Research and Treatment - April 17, 2019 Category: Cancer & Oncology Source Type: research

Propagation of functional estrogen receptor positive normal human breast cells in 3D cultures
ConclusionsWe successfully identified conditions for the maintenance and propagation of functional ER  + cells from normal human breast tissues. We propose that these 3D cultures will overcome limitations of conventional 2D cultures of partially or fully transformed cell lines by sustaining normal endocrine function and growth regulation of the cell populations that comprise intact breasts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 16, 2019 Category: Cancer & Oncology Source Type: research

Downregulation of APE1 potentiates breast cancer cells to olaparib by inhibiting PARP-1 expression
ConclusionTo acquire better benefits for HR-proficient breast cancer patients, developing chemotherapeutic drugs antagonize APE1 would be an effective strategy to improve the clinical outcome of PARP inhibitors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 15, 2019 Category: Cancer & Oncology Source Type: research

miR-106b-5p and miR-17-5p could predict recurrence and progression in breast ductal carcinoma in situ based on the transforming growth factor-beta pathway
ConclusionmiR-106b-5p and miR-17-5p might have a role in breast cancer recurrence and progression by suppressing TGF- β activity, leading to early breast cancer carcinogenesis. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 15, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer
Unfortunately in the original publication of the article, the author ’s funding support has been mentioned incorrectly. The correct funding statement should read as “This work was supported by the Morgan Welch Inflammatory Breast Cancer Research Program, the State of Texas Rare and Aggressive Breast Cancer Research Program, MD Anderson’s Cancer Center Support G rant (P30CA016672, used the Characterized Cell Line Core Facility and Flow Cytometry and Cellular Imaging Facility), and Spirita Oncology, LLC.”The first affiliations was incorrect in the original article. The correct information is given bel...
Source: Breast Cancer Research and Treatment - April 15, 2019 Category: Cancer & Oncology Source Type: research

Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study
ConclusionsOur study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 13, 2019 Category: Cancer & Oncology Source Type: research

Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases
AbstractPurposeBrain metastases from breast cancer are frequently managed with brain-directed radiation but the impact of subtype on intracranial recurrence patterns after radiation has not been well-described. We investigated intracranial recurrence patterns of brain metastases from breast cancer after brain-directed radiation to facilitate subtype-specific management paradigms.MethodsWe retrospectively analyzed 349 patients with newly diagnosed brain metastases from breast cancer treated with brain-directed radiation at Brigham and Women ’s Hospital/Dana-Farber Cancer Institute between 2000 and 2015. Patients were ...
Source: Breast Cancer Research and Treatment - April 13, 2019 Category: Cancer & Oncology Source Type: research