False negative breast cancers on imaging and associated risk factors: a single institution six-year analysis
ConclusionOur findings suggest that supplemental screening may be useful in breast cancer survivors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 14, 2024 Category: Cancer & Oncology Source Type: research

Aging-accumulated methylmalonic acid serum levels at breast cancer diagnosis are not associated with distant metastases
ConclusionBaseline serum MMA levels in patients with breast cancer are not correlated with secondary distant metastasis. Evidence in the mouse model suggests that the presence of a tumor perturbates MMA levels. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 13, 2024 Category: Cancer & Oncology Source Type: research

Immediate and delayed risk of breast cancer associated with classic lobular carcinoma in situ and its variants
ConclusionLCIS has both an immediate risk (19.3%) and a delayed risk (18.6%) for cancer with 90.9% occurring in the ipsilateral breast (63.6% at and 27.3% away from the site of LCIS) and 9.1% occurring in the contralateral breast. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 12, 2024 Category: Cancer & Oncology Source Type: research

Infertility and risk of postmenopausal breast cancer in the women ’s health initiative
ConclusionThese findings suggest that infertility may be modestly associated with future risk of postmenopausal breast cancer due to age at first pregnancy and highlight the importance of incorporating reproductive history across the life course into breast cancer analyses. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 9, 2024 Category: Cancer & Oncology Source Type: research

Correlation between trophoblast cell-surface antigen-2 (Trop-2) expression and pathological complete response in patients with HER2-positive early breast cancer treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab
ConclusionThese findings suggest a potential role of Trop-2 expression as a biomarker of resistance to neoadjuvant chemotherapy plus dual HER2 blockade and may become a strategic target for future combinations in HER2-positive EBC patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 8, 2024 Category: Cancer & Oncology Source Type: research

Survival analysis of patients with brain metastases at initial breast cancer diagnosis over the last decade
ConclusionOver the last decade, the median OS of patients with brain metastases at initial breast cancer diagnosis remained poor; however, a substantial minority survive 5 or more years, with rates higher in patients with HER2-positive tumors. In addition to tumor subtype, OS varied according to age, extracranial metastases, and sociodemographic factors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 7, 2024 Category: Cancer & Oncology Source Type: research

Neoadjuvant anthracycline-based (5-FEC) or anthracycline-free (docetaxel/carboplatin) chemotherapy plus trastuzumab and pertuzmab in HER2  + BC patients according to their TOP2A: a multicentre, open-label, non-randomized phase II trial
ConclusionOur results showed high pCR rates with Trastuzumab and Pertuzumab associated to chemotherapy. They were similar in TOP2A  + and TOP2A- groups and the current role of neoadjuvant anthracycline-based chemotherapy remains questioned.Trial registration numberNCT02339532 (registered on 14/12/14). (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 7, 2024 Category: Cancer & Oncology Source Type: research

Identify risk factors affecting participation of Turkish women in mammography screening for breast cancer prevention
ConclusionSince adherence to mammography increases with age, it is recommended to pay importance to education for women approaching the age of mammography screening. Educated individuals are expected to have access to multiple sources of information as to cancer and to access this information more easily. In order to gain more insight into the recommended preventive measures and outcomes related to cancer, it is suggested to review policies, which will increase the educational level of women, and provide privileges in the field of education. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 7, 2024 Category: Cancer & Oncology Source Type: research

Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes
ConclusionThese results question the utility of NLR as a prognostic biomarker in early breast cancer and suggest the lack of correlation of NLR with tumor microenvironment immune response. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 7, 2024 Category: Cancer & Oncology Source Type: research

Intertumoral heterogeneity of bifocal breast cancer: a morphological and molecular study
ConclusionIn bifocal BC, intertumoral heterogeneity on the morphological, immunohistochemical and molecular level is common, with discordant intrinsic subtype in up to 25% between individual foci, with about 8% clinically relevant discordances. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 7, 2024 Category: Cancer & Oncology Source Type: research

A whole-food, plant-based randomized controlled trial in metastatic breast cancer: weight, cardiometabolic, and hormonal outcomes
ConclusionWFPB dietary changes during treatment for metastatic breast cancer are well tolerated and significantly improve weight, cardiometabolic and hormonal parameters. Longer studies are warranted to assess the durability of changes.Trial registration First registered at Clinicaltrials.gov (NCT03045289) on February 7, 2017. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 6, 2024 Category: Cancer & Oncology Source Type: research

Immunohistochemical assessment of HER2 low breast cancer: interobserver reproducibility and correlation with digital image analysis
ConclusionAlthough breast subspecialty pathologists were relatively consistent in evaluating BC with HER2 IHC scores of 0 and 1  +, DIA may be a reliable supplementary tool to enhance the standardization and quantification of HER2 IHC assessment, especially in challenging cases where results may be ambiguous (i.e., scores 0–1 +). These findings hold promise for improving the accuracy and consistency of HER2 testing. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 5, 2024 Category: Cancer & Oncology Source Type: research

Survival among patients with untreated metastatic breast cancer: “What if I do nothing?”
ConclusionsPatients with dnMBC who do not receive treatment are more likely to be older, present with comorbid conditions, and have clinically aggressive disease. Similar to those who do receive treatment, survival in an untreated population is associated with select patient and disease characteristics. However, the prognosis for untreated dnMBC is dismal. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 5, 2024 Category: Cancer & Oncology Source Type: research

Burden of female breast cancer in India: estimates of YLDs, YLLs, and DALYs at national and subnational levels based on the national cancer registry programme
ConclusionThe female BC burden in India was significantly high in 2016 and is expected to substantially increase. Undertaking a multidisciplinary, context-specific approach for its prevention and control  can address this rising burden. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 4, 2024 Category: Cancer & Oncology Source Type: research

Primary MALT lymphoma of the breast: pathological and radiological characteristics
ConclusionPrimary MALT breast lymphomas are usually indolent and non-systemic, and local radiotherapy may effectively alleviate local symptoms. Radiological findings show overlap with benign morphological features, which can delay the diagnosis of this unusual etiology. Although further studies involving a larger cohort could help establish the clinical and radiological characteristics of primary breast MALT lymphomas, pathology remains the primary method of diagnosis.Trial registration numberUniversity Health Network Ethics Committee (CAPCR/UHN REB number 19 –5844), retrospectively registered. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - March 1, 2024 Category: Cancer & Oncology Source Type: research