Predictive value of lymphoscintigraphy in patients with breast cancer-related lymphedema undergoing complex decongestive therapy
AbstractPurposeWe evaluated the prognostic value of lymphoscintigraphy after complex decongestive therapy (CDT) in breast cancer-related secondary lymphedema.MethodsPrior to CDT, 80 patients with breast cancer-related lymphedema underwent a99mTc tin-colloid lymphoscintigram. We investigated the uptake patterns of axillary lymph nodes (LNs), main lymphatic vessels, collateral lymphatic vessels, and dermal back flow in the lymphoscintigraphy of the upper extremities. We also compared the above findings with other clinical variables between patients who respond well to CDT (responders) and those who do not (poor responders). ...
Source: Breast Cancer Research and Treatment - November 12, 2018 Category: Cancer & Oncology Source Type: research

Concordance with BRCA1 / 2 testing guidelines among women in The Health of Women (HOW) Study ®
ConclusionAlmost 30% of women were under-tested, indicating that many high-risk women who may benefit from genetic testing are currently being missed. Without appropriate testing, providers are unable to tailor screening recommendations to those carrying mutations who are at highest risk. Patient and healthcare provider education and outreach targeted to low-income and under-served populations may assist in reducing under-testing. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 9, 2018 Category: Cancer & Oncology Source Type: research

Impact of pre-diagnosis depressive symptoms and health-related quality of life on treatment choice for ductal carcinoma in situ and stage I breast cancer in older women
ConclusionOlder women at risk for MDD before DCIS diagnosis were less likely to receive RT after BCS, compared to BCS alone or mastectomy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 8, 2018 Category: Cancer & Oncology Source Type: research

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines
Conclusions and recommendationsCritical appraisal of the literature provided evidence for the value of comprehensiveCYP2D6 genotyping panels in guiding treatment decisions for non-metastatic ER-positive breast cancer patients. Based on this information, it is recommended that alternatives to standard tamoxifen treatments may be considered inCYP2D6 poor or intermediate metabolizers. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 8, 2018 Category: Cancer & Oncology Source Type: research

Survivorship care visits in a high-risk population of breast cancer survivors
ConclusionsCompared to the JHCR cohort, SV participants had higher risk cancers and a high frequency of comorbidities potentially associated with breast cancer and therapy. These high-risk patients may benefit most from specific interventions targeting survivorship care, and their experiences may help improve care delivery models. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2018 Category: Cancer & Oncology Source Type: research

Racial/ethnic disparities in inflammatory breast cancer survival in the Michigan Cancer Surveillance Program
ConclusionsA comprehensive case definition should be utilized to avoid underestimation of IBC and to better understand this aggressive disease. Further research is needed to identify underlying causes and develop effective interventions to reduce IBC survival disparities between NHB and NHW women. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 7, 2018 Category: Cancer & Oncology Source Type: research

Pretreatment anti-Mullerian hormone-based nomogram predicts menstruation status after chemotherapy for premenopausal women with hormone receptor-positive early breast cancer
AbstractPurposeOvarian function is important for optimizing endocrine treatment in patients with hormone receptor-positive (HR+) early breast cancer (eBC). The aim of the study was to determine whether patients ’ pretreatment levels of anti-Mullerian hormone (AMH) were associated with menses status after chemotherapy and to build a predictive nomogram model for amenorrhea in women with HR+ eBC.MethodsBetween August 2013 and December 2014, 120 premenopausal patients with HR+  eBC were included retrospectively. The associations among age, prechemotherapy levels of AMH, follicle-stimulating hormone (FSH),a...
Source: Breast Cancer Research and Treatment - November 3, 2018 Category: Cancer & Oncology Source Type: research

Racial disparities in breast cancer persist despite early detection: analysis of treatment of stage 1 breast cancer and effect of insurance status on disparities
ConclusionsDespite selecting for early-stage breast cancer, racial disparities between White and Black women in time to all forms of breast cancer treatment persist. These disparities while likely not oncologically significant do suggest institutional barriers for obtaining care faced by women of color which may not be addressed with improving access to mammography alone. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 3, 2018 Category: Cancer & Oncology Source Type: research

Quantitative comparison of drug efficacy in treating hot flashes in patients with breast cancer
ConclusionsProgesterone showed the highest efficacy, followed by SSRIs/SNRIs, neuroleptic agents, and tibolone, while phytoestrogen and other types of drugs showed no efficacy advantages. There is a significant association between the baseline of hot flashes and drug efficacy, while there was no significant difference between breast cancer patients and natural menopausal women. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - November 2, 2018 Category: Cancer & Oncology Source Type: research

Clinical subtypes and prognosis in breast cancer according to parity: a nationwide study in Korean Breast Cancer Society
AbstractPurposeWe explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes.MethodsA total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death.ResultsThe patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) ...
Source: Breast Cancer Research and Treatment - November 2, 2018 Category: Cancer & Oncology Source Type: research

Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer
AbstractPurposeThe purpose of this study was to evaluate longitudinal changes in brain gray matter density (GMD) before and after adjuvant chemotherapy in older women with breast cancer.MethodsWe recruited 16 women aged ≥ 60 years with stage I–III breast cancers receiving adjuvant chemotherapy (CT) and 15 age- and sex-matched healthy controls (HC). The CT group underwent brain MRI and the NIH Toolbox for Cognition testing prior to adjuvant chemotherapy (time point 1, TP1) and within 1 month after chemothera py (time point 2, TP2). The HC group underwent the same assessments at matched intervals. G...
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Impact of primary breast cancer therapy on energetic capacity and body composition
AbstractPurposeThis observational study was designed to measure baseline energy parameters and body composition in early-stage breast cancer patients, and to follow changes during and after various modalities of treatment. This will provide information to aid in the development of individualized physical activity intervention strategies.MethodsPatients with newly diagnosed stage 0 –III breast cancer were enrolled into three cohorts: A (local therapy alone), B (endocrine therapy), or C (chemotherapy with or without endocrine therapy). At baseline, 6 months, and 12 months, subjects underwent a stationary bicy...
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Quantifying performance thresholds for recommending screening mammography: a revealed preference analysis of USPSTF guidelines
ConclusionsUsing USPSTF revealed preferences, 31 –74% reductions in false-positives would be required to recommend mammography screening beyond biennial screening starting at age 50. Widespread implementation of tomosynthesis and reducing recall rates to the lower end of recommended recall rates (5–12%) would provide support for expanding scre ening beyond biennial screening in women age 50. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

A comparison of the imaging features of pleomorphic and classical invasive lobular carcinoma
AbstractPurposePleomorphic invasive lobular carcinoma (pILC) is a distinct morphological variant of ILC with a poorer prognosis than classical ILC (cILC). The aim of this study was to ascertain whether the conventional imaging appearances of the two entities differ.MethodsA single-center retrospective review of conventional imaging was undertaken in 150 consecutive patients with histopathologically confirmed ILC (38 pILC; 112 cILC) between April 2010 and July 2015. Mammographic and sonographic findings were evaluated using the BI-RADS lexicon by a radiologist blinded to pathology, and the findings in the two groups were co...
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Associations of preoperative breast magnetic resonance imaging with subsequent mastectomy and breast cancer mortality
ConclusionsPre-operative MRI was associated with improved outcomes among older women with breast cancer receiving BCS alone, but not among those receiving BCS plus radiotherapy. Further research is needed to identify appropriate settings for which MRI may be helpful. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Substantial evidence for the clinical significance of missense variant BRCA1 c.5309G & gt;T p.(Gly1770Val)
ConclusionsWe provide evidence thatBRCA1 c.5309G>T p.(Gly1770Val), previously described as a Moroccan founder variant, should be treated as a disease-causing variant despite a lack of evolutionary conservation at this amino acid position. Additionally, we stress that bioinformatic information should be used in combination with other data, either direct clinical evidence or some form of clinical calibration, to arrive at a final clinical classification. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Elevated BMI might more significantly affect the outcome negatively in luminal type breast cancer patients with brain metastases
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Re: Elevated BMI might more significantly affect the outcome negatively in luminal type breast cancer patients with brain metastases
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

The association between estrogen receptor alpha gene rs746432 polymorphism and the risk of breast cancer
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

Pure or mixed-type classical invasive lobular carcinoma might show different imaging features
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 16, 2018 Category: Cancer & Oncology Source Type: research

CDK4/6 inhibitors in advanced hormone receptor-positive/HER2-negative breast cancer: a systematic review and meta-analysis of randomized trials
ConclusionEmerging data provide a new standard treatment for advanced HR+/HER2 − breast cancer, regardless of menopausal status, prior hormonal/chemotherapy treatments delivered, sites of metastasis. However, benefits should be balanced with longer treatment duration, toxicities, and costs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Determinants of non-adherence to adjuvant endocrine treatment in women with breast cancer: the role of comorbidity
AbstractPurposeTo examine factors associated with non-adherence during 5  years of endocrine treatment, including the possible influence of comorbidity burden and specific medical conditions.MethodsFrom all women diagnosed with stage I –III, ER-positive breast cancer in Stockholm-Gotland, Uppsala–Örebro and Northern Sweden between 2006 and 2009, we included 4645 women who had at least one dispensation of tamoxifen or aromatase inhibitors (AIs) and 5 years of follow-up without distant recurrence. A medical possession ratio of
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

De novo vitamin D supplement use post-diagnosis is associated with breast cancer survival
AbstractPurposeExperimental laboratory data have indicated a protective effect of vitamin D on breast cancer progression, while epidemiological evidence is growing. Using pharmacy claims data, this study investigates the association between vitamin D supplement use initiated after a breast cancer diagnosis and associated mortality.MethodsWomen aged 50 –80 years with a record of invasive breast cancer were identified on the National Cancer Registry Ireland database (n = 5417). Initiation of de novo vitamin D post-diagnosis was identified from linked national prescription data (n = 2581...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Screening status, tumour subtype, and breast cancer survival: a national population-based analysis
ConclusionsScreening status was strongly associated with subtype and this association persisted after adjustment for covariates including tumour stage and grade. After correcting for lead-time bias and adjusting for stage, subtype, grade and socio-demographic variables, no significant survival difference was demonstrated for women with screen-detected cancer in the 5-year period post-diagnosis. Since we are adjusting for stage, subtype and other variables, the lack of difference between these groups would be expected but has not been demonstrated in studies which do not correct for lead time bias. (Source: Breast Cancer Re...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Population-based validation of the National Cancer Comprehensive Network recommendations for breast cancer staging
AbstractObjectiveThe aim of the current study is to evaluate the performance characteristics of the National Comprehensive Cancer Network (NCCN) staging recommendations for breast cancer with regard to the detection of lung, bone, and liver metastases.MethodsSurveillance, epidemiology, and end points (SEER) database (2010 –2015) was accessed, and patients with breast cancer and complete information about T stage and clinical N stage, ER status, Her2 status, and metastatic sites were extracted. Performance characteristics evaluated for the current study included sensitivity, specificity, positive predictive ...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen
ConclusionsBased on this model, monitoring of endoxifen in adjuvant ER α + breast cancer patients treated with tamoxifen is likely to add QALYs and save costs from a healthcare payer perspective. We advise clinicians to consider integrating serum endoxifen concentration monitoring into standard adjuvant tamoxifen treatment of ERα + breast cancer patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Occult breast cancer may originate from ectopic breast tissue present in axillary lymph nodes
ConclusionIt is important to distinguish between “primary” OBC in ALNs and “metastatic” OBC from micro-primary breast tumor. Further studies are required to determine if omission of mastectomy and WBRT is acceptable. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Perometry versus simulated circumferential tape measurement for the detection of breast cancer-related lymphedema
ConclusionsThis hypothesis-generating study suggested the superiority of anatomic landmark-based circumferential tape measurement compared to interval-based methods, while generating questions about the underestimation of upper arm volume and overestimation of forearm volume of circumferential tape measurement compared to perometry. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
ConclusionOur findings suggest a weight loss intervention in stage 0 and 1 breast cancer survivors may lead to telomere lengthening, compared to a shortening in their usual care counterparts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Clinical subtypes and prognosis of pregnancy-associated breast cancer: results from the Korean Breast Cancer Society Registry database
ConclusionPABC showed different biologic features than non-PABC. PABC had a particularly poor prognosis in the luminal B (HR+ HER2-highKi67) and HER2 subtypes. To improve the prognosis of PABC, treatment should be considered according to subtype. Development of drugs that can be used during pregnancy is needed. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines
ConclusionOur results indicated this approach with PARP3 inhibitors and vinorelbine is unique and promising for breast cancer patients with metastases. This combination could significantly increase the survival of breast cancer patients with metastases. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer
ConclusionsHigh RAPH1 expression is correlated with aggressive breast cancer phenotypes and provides independent prognostic value in invasive breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Towards treatment personalisation in triple negative breast cancer: role of platinum-based neoadjuvant chemotherapy
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Sexual health in long-term breast cancer survivors
ConclusionSexual health and uro-genital symptom counseling should be provided to BCS, particularly pre/peri-menopausal patients, even at long-term follow-up. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

The yield of full BRCA1 / 2 genotyping in Israeli high-risk breast/ovarian cancer patients who do not carry the predominant mutations
AbstractPurposeBRCA1 andBRCA2 genotyping results have clinical implications for cancer risk assessment and targeted therapy. Current practice in Israel is to genotype for the predominantBRCA1/2 mutations first, followed by full gene analysis in eligible mutation-negative individuals. This work assessed the rate of non-predominant mutations inBRCA1/2 in ethnically diverse high-risk cases.MethodsBreast and/or ovarian cancer patients who tested negative for the predominantBRCA1/2 mutations were referred for comprehensiveBRCA1/2 genotyping if calculated risk for carrying aBRCA mutation was ≥ 10%.ResultsOf 1258 eligible...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Impact of race, ethnicity, and socioeconomic factors on receipt of radiation after breast conservation surgery: analysis of the national cancer database
We examined trends in RT use over 10  years, and the impact of sociodemographic factors on the receipt of standard-of-care RT, using the National Cancer Database (NCDB).Materials/methodsWomen under age 70 with invasive breast cancer who underwent BCS from 2004 to 2014 were analyzed. Receipt of RT was evaluated in the whole cohort and by time period to identify temporal trends. Multiple logistic regression models were used to assess associations between factors such as race, insurance status, ethnicity, and receipt of RT.ResultsA total of 501,733 patients met eligibility criteria. The percentage of patients undergoing ...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Molecular subtypes of screen-detected breast cancer
AbstractBackgroundDetection of breast cancers by mammographic screening confers a survival advantage of 20 –50% compared to symptomatic presentations. The improved prognosis is only partly explained by stage migration. The distribution of the molecular subtypes of screen-detected breast cancer (SDBC) or their HER2 status has not been studied extensively. We wished to address these issues through the st udy of a large series of SDBC, with other presentations serving as controls.DesignDeidentified cases of female invasive cancer, diagnosed in Australia and New Zealand during 2005 –2015, were retrieved from the Br...
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Glucocorticoids in breast cancer treatment: real benefit or selection bias?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Heterogeneity of tumor cells and metastases in breast cancer patients: cause or consequence?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

A nomogram to predict pathologic complete response (pCR) and the value of tumor-infiltrating lymphocytes (TILs) for prediction of response to neoadjuvant chemotherapy (NAC) in breast cancer patients
ConclusionsHigh pre-NAC TIL levels were significantly predictive of pCR in BC, and can act as a surrogate marker for predicting therapeutic effects of a TCHP regimen for HER2-positive BC. Post-NAC TILs in residual disease were a new prognostic marker of risk stratification for long-term survival. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Challenge for identifying the origin of occult breast cancer for optimizing local therapy
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 15, 2018 Category: Cancer & Oncology Source Type: research

Mucin 2 (MUC2) modulates the aggressiveness of breast cancer
ConclusionsMUC2 plays an important role in mediating proliferation, apoptosis and metastasis of breast cancer cells. MUC2 may be important in guiding treatment and predicting outcomes in breast cancer patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 13, 2018 Category: Cancer & Oncology Source Type: research

One year versus a shorter duration of adjuvant trastuzumab for HER2-positive early breast cancer: a systematic review and meta-analysis
AbstractIntroductionOne year is the standard duration of adjuvant trastuzumab for human epidermal receptor-2 (HER2) positive (HER2+) breast cancer (BC). Indeed, a shorter duration of trastuzumab can reduce cardiotoxicity and the costs involved and could provide the same benefit as a one-year treatment. We evaluated the available evidence from randomised controlled trials (RCTs) by comparing 1  year versus a shorter duration of adjuvant trastuzumab for HER2+ BC.Patients and methodsA systematic search of PubMed, EMBASE, The Cochrane Library and conference proceedings was carried out in order to identify the RCTs that in...
Source: Breast Cancer Research and Treatment - October 13, 2018 Category: Cancer & Oncology Source Type: research

Which patients with sentinel node-positive breast cancer after breast conservation still receive completion axillary lymph node dissection in routine clinical practice?
We examined implementation of evidence from this trial into routine clinical management.MethodsData were included from patients diagnosed with primary breast cancer in German breast cancer units between 2008 and 2015 and analysed retrospectively from a prospective maintained database. Descriptive analyses assessed time-trend changes in axillary surgery. Factors associated with cALND in patients with 1 or 2 positive SLNs were identified using multivariable logistic regression analysis.ResultsOverall, 179 breast cancer units provided data for 188,909 patients, of whom 13,741 (7.3%) had pT1/2cN0M0 invasive breast cancer with ...
Source: Breast Cancer Research and Treatment - October 12, 2018 Category: Cancer & Oncology Source Type: research

Improving the competency of medical students in clinical breast examination through a standardized simulation and multimedia-based curriculum
This study aimed to determine if SSMBI training resulted in better performance (examination scores and detection of abnormal findings) than the traditional teaching method.MethodsNovice fourth-year medical students were exposed to the SSMBI curriculum (n = 68) or traditional (n = 52) training. The traditional group was taught by a lecture and attending weekly clinics where they had hands-on experience. The SSMBI group underwent a structured lecture followed by an instructional video and dedicated simulated teaching. Both groups were assessed through a written knowledg e exam and an objectiv...
Source: Breast Cancer Research and Treatment - October 12, 2018 Category: Cancer & Oncology Source Type: research

High patient satisfaction with a simplified BRCA1 / 2 testing procedure: long-term results of a prospective study
ConclusionsSatisfaction with a simplifiedBRCA1/2 testing procedure was very high. Written pre-test information has now replaced in-person pre-test counseling for breast cancer patients in our health care region. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 11, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer
In the original publication, the sixth author name was published incorrectly as A. Wood. The correct author name should read as W. A. Wood. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 11, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung
In the original publication, the sixth author name was published incorrectly as Matthew Stein. The correct author name should read as Matthew K Stein. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 11, 2018 Category: Cancer & Oncology Source Type: research

The impact of gene expression profile testing on confidence in chemotherapy decisions and prognostic expectations
ConclusionsGEP testing was not associated with greater confidence in chemotherapy decisions. Better communication about GEP testing and the implications for recurrence risk may improve women ’s decisional confidence. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 10, 2018 Category: Cancer & Oncology Source Type: research

Impact of Topoisomerase II α, PTEN, ABCC1/MRP1, and KI67 on triple-negative breast cancer patients treated with neoadjuvant chemotherapy
AbstractPurposeTriple-negative breast cancer (TNBC) patients with residual disease following neoadjuvant chemotherapy (NAC) harbor higher risk of relapse, and eventual demise compared to those who achieve pathologic complete response. Therefore, in this study, we assessed a panel of molecules involved in key pathways of drug resistance and tumor progression before and after NAC in TNBC patients, in order to clarify the underlying mechanisms.MethodsWe studied 148 TNBC Japanese patients treated with anthracycline/taxane-based NAC. KI67, Topoisomerase II α (TopoIIα), PTEN, p53, Bcl2, vimentin, ABCG2/BCRP1, ABCB1/M...
Source: Breast Cancer Research and Treatment - October 10, 2018 Category: Cancer & Oncology Source Type: research