Width of margins in phyllodes tumors of the breast: the controversy drags on? —a systematic review and meta-analysis
The objective of this systematic review was to identify and compare studies that assessed these different practices.MethodsA systematic review was performed through five databases up to April 2019. Studies exploring the association between the width of margins, subtypes of PT, and the LR and DM rates were considered for inclusion. A statistical model for analyzing sparse data and rare events was used.ResultsThirteen studies met eligibility criteria and were selected. Considering a threshold of 10  mm (margins 
Source: Breast Cancer Research and Treatment - September 15, 2020 Category: Cancer & Oncology Source Type: research

Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
AbstractPurposeTo determine the longitudinal impact of adjuvant chemotherapy and tamoxifen-only treatments on the reproductive potential of women with breast cancer by using a sensitive ovarian reserve marker anti-Mullerian hormone (AMH) as a surrogate.MethodsOne-hundred-and-forty-two women with a primary diagnosis of breast cancer were prospectively followed with serum AMH assessments before the initiation, and 12, 18 and 24  months after the completion of adjuvant chemotherapy or the start of tamoxifen-only treatment. The chemotherapy regimens were classified into Anthracycline-Cyclophosphamide-based (AC-based) and ...
Source: Breast Cancer Research and Treatment - September 15, 2020 Category: Cancer & Oncology Source Type: research

Long-term survival outcomes of repeat lumpectomy for ipsilateral breast tumor recurrence: a propensity score-matched analysis
ConclusionsNo significant differences were observed in survival outcomes between patients with IBTR who underwent repeat lumpectomy or total mastectomy. Our results can be helpful in selecting the appropriate surgical method for IBTR. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2020 Category: Cancer & Oncology Source Type: research

The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study
ConclusionUse of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of endocrine therapy and patients preferences in early breast cancer: results of Elena study
ConclusionsThis is a large study of patient preferences on HT. Compared with other studies with similar design, the patients included in the present study required larger benefits to make adjuvant therapy worthwhile. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Racial and ethnic disparities in 21-gene recurrence scores, chemotherapy, and survival among women with hormone receptor-positive, node-negative breast cancer
ConclusionsBlack women were more likely to have a high-risk RS tumor and less likely to receive chemotherapy in the group of high RS, especially those  ≥ 65 years. Further studies are needed to identify barriers to chemotherapy in black patients with high RS scores. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Body mass index (BMI) and benefit from adjuvant chemotherapy in breast cancer: is it enough?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Clinical practice to address tamoxifen nonadherence
AbstractThe primary and secondary benefits of tamoxifen as adjuvant therapy in women with hormone-receptor-positive breast cancer are substantial: a 1% decrease in the risk of death each year for 10  years with each additional year of treatment during the first 5 years. Considerable data, however, indicate that these benefits are lost to many patients because of treatment nonadherence. Nonadherence is examined within the framework of the Common-Sense Model of Self-Regulation to describe patie nts’ models of disease and treatment that organize their thinking and behavior, and the crucial role of the practiti...
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Factors associated with being diagnosed with high severity of breast cancer: a population-based study in Queensland, Australia
ConclusionScreen-detected women and women who had mammograms biennially had lower odds of being diagnosed with high-severity breast cancer, which highlighted the benefit of regular breast cancer screening. Women in subgroups who are more likely to have more severe cancers should be particularly encouraged to participate in regular mammography screening. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2020 Category: Cancer & Oncology Source Type: research

Tumor necrosis by pretreatment breast MRI: association with neoadjuvant systemic therapy (NAST) response in triple-negative breast cancer (TNBC)
ConclusionNo significant association was found between necrosis by pretreatment MRI or the quantitative imaging characteristics of tumor necrosis and response to NAST in TNBC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 13, 2020 Category: Cancer & Oncology Source Type: research

The efficacy and safety of pertuzumab plus trastuzumab and docetaxel as a first-line therapy in Japanese patients with inoperable or recurrent HER2-positive breast cancer: the COMACHI study
ConclusionsOur results suggest similar efficacy and safety for pertuzumab plus trastuzumab and docetaxel in Japanese patients compared with the overall population of CLEOPATRA, providing further support for this combination therapy as standard of care for Japanese patients with inoperable or recurrent HER2-positive breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 13, 2020 Category: Cancer & Oncology Source Type: research

Predicting adjuvant endocrine therapy initiation and adherence among older women with early-stage breast cancer
ConclusionsThe best models in the present study were poorly predictive, demonstrating that the reasons for initiation and adherence to AET are complex and individual to the patient, and therefore difficult to predict. Initiation and adherence to AET are important factors in decision-making regarding whether or not to forgo adjuvant RT. In order to better formulate treatment plans for this population, future work should focus on improving individual prediction of AET initiation and adherence. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

FDG-PET/CT in high-risk primary breast cancer —a prospective study of stage migration and clinical impact
ConclusionsFDG-PET/CT had a substantial impact on staging and change of treatment in women with high-risk primary breast cancer, and further examination of incidental findings was considered clinically relevant. Our findings suggest that FDG-PET/CT should be considered for primary staging in high-risk primary breast cancer to improve treatment planning. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Quantitative proteomics reveals stage-specific protein regulation of triple negative breast cancer
ConclusionsOverall, our proteomic data presented precise quantification of potential signatures, signaling pathways, regulatory networks, and characteristic differences in each clinicopathological subgroup. The proteome provides complementary information for TNBC accurate subtype classification and therapeutic targets research. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Risk factors for implant failure following revision surgery in breast cancer patients with a previous immediate implant-based breast reconstruction
AbstractPurposeThe aim of the current study was to evaluate risk factors and timing of revision surgery following immediate implant-based breast reconstruction (IBR).MethodsThis retrospective cohort included women with a previous therapeutic mastectomy and implant-based IBR who had undergone implant revision surgery between 2005 and 2015. Data were collected by medical chart review and registered in the Stockholm Breast Reconstruction Database. The primary endpoint was implant removal due to surgical complications, i.e. implant failure.ResultsThe cohort consisted of 475 women with 707 revisions in 542 breasts. Overall, 33 ...
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Predictors of increased risk for early treatment non-adherence to oral anti-estrogen therapies in early-stage breast cancer patients
ConclusionsThe presence of a composite profile of psychological and menopause symptoms prior to AET initiation may help to identify early treatment non-adherence. Results can be used to identify patients at risk for non-adherence and to guide psychological and symptom management interventions. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Assessment of stromal tumor infiltrating lymphocytes and immunohistochemical features  in invasive micropapillary breast carcinoma with long-term outcomes
AbstractPurposeWe studied the long-term outcomes of invasive micropapillary carcinoma (IMPCs) of the breast in relation to stromal tumor infiltrating lymphocytes (sTILs), prognostic biomarkers and clinicopathological features.MethodsStage I-III IMPCs treated with upfront surgery at our institution (January 2000 and December 2016) were included. Central pathology review was performed and sTILs (including zonal distribution and hot spot analysis) and tumor-associated plasma cells (TAPC) were evaluated. Expression of P53, BCL2, FOXP3, and WT1, which are variably linked to breast cancer prognosis, was measured by immunohistoch...
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Treatment interruption and discontinuation  of hormonal therapy in hormone receptor-positive breast cancer patients
ConclusionsThis study showed that HT interruptions and discontinuation were common, often associated with HT-related symptoms. Clinicians caring for breast cancer patients on HT should monitor closely for treatment-emergent symptoms, especially women with pre-existing disorders, and support them to continue therapy through aggressive symptom management and other patient-centered approaches. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2020 Category: Cancer & Oncology Source Type: research

Family history of breast cancer in men with non- BRCA male breast cancer: implications for cancer risk counseling
AbstractPurposeThe role of genetic predisposition in male breast cancer (MBC) patients who test negative for aBRCA mutation is unclear. The aim of this study is to define the association between MBC and family history of breast cancer in patients without mutations inBRCA1 or BRCA2.MethodsWe conducted an unmatched case –control study with men who received commercial testing for germline mutations in cancer susceptibility genes, including 3,647 MBC cases who tested negative for deleterious mutations inBRCA1/BRCA2, and 4,269 men with a personal history of colorectal cancer who tested negative for mutations in DNA mismat...
Source: Breast Cancer Research and Treatment - September 11, 2020 Category: Cancer & Oncology Source Type: research

UBR5 over-expression contributes to poor prognosis and tamoxifen resistance of ERa+  breast cancer by stabilizing β-catenin
ConclusionsThese findings suggested that UBR5/ β-catenin signaling might be a potential therapeutic target for TAM-resistant ERa+ breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Pre-diagnostic allostatic load and health-related quality of life in a cohort of Black breast cancer survivors
ConclusionThese findings suggest that higher AL, particularly when measured using the inflammatory profile-based measure, was associated with poorer HRQOL, namely FWB and FACT-G, among Black breast cancer survivors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Effect of delays in initiation of adjuvant endocrine therapy on survival among women with breast cancer
ConclusionThis study suggests that there may be no adverse impact on survival if initiation of AET occurs 12 to 24  months after initial diagnosis compared to within 12 months of diagnosis as currently recommended. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Vitiligo-like lesions in patients with advanced breast cancer treated with cycline-dependent kinases 4 and 6 inhibitors
ConclusionsWe present for the first time, to our knowledge, a case series of vitiligo-like lesions developing in patients with advanced breast cancer treated with cyclin-dependent kinases 4 and 6 inhibitors. We showed that such lesions further impair the patients ’ quality of life and their treatment is challenging. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Utility of 70-kV single-energy CT in depicting the extent of breast cancer for preoperative planning
ConclusionsLow-tube voltage (70-kV) CECT is the preferred modality to identify breast cancer lesions and tumor extent for preoperative planning because it has a similar diagnostic ability to CEMR and can be performed in the supine position. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Impalpable breast lesion localisation, a logistical challenge: results of the UK iBRA-NET national practice questionnaire
ConclusionWires are currently the most commonly used localisation technique but are associated with significant logistical issues. Newer techniques may offer a better solution but will need robust evaluation before they are adopted to ensure safety and efficacy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Telerehabilitation for patients with breast cancer through the COVID-19 pandemic
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 10, 2020 Category: Cancer & Oncology Source Type: research

Comparison of resection margin status after single or double radiopaque marker insertion for tumor localization in breast cancer patients receiving neoadjuvant chemotherapy
ConclusionsNumber of inserted markers for tumor localization did not affect the pathologic margin status after BCS. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 9, 2020 Category: Cancer & Oncology Source Type: research

Correlation of circulating or disseminated tumor cells with the Oncotype DX Recurrence Score
ConclusionsHigh Oncotype DX RS did not correlate with CTCs in blood or DTCs in bone marrow in our study. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Lobular neoplasia occult on conventional imaging and diagnosed on MRI-guided biopsy: can we estimate upgrade on surgical pathology?
AbstractPurposeThe goal of this study is to evaluate the frequency and imaging features of lobular neoplasia (LN) diagnosed on MRI-guided biopsy, determine the upgrade rate to malignancy, and assess for any features that may be associated with an upgrade on surgical excision.Materials and methodsResearch ethical board approved the review of consecutive patients with MRI-detected LN between January 2009 and December 2018 with differentiation between pure LN and LN with associated other high-risk lesions. The final outcome was determined by final pathology results from surgical excision or 24  months of follow-up. Appro...
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Racial differences in genomic testing and receipt of endocrine therapy in early-stage breast cancer
AbstractPurposeGenomic testing in early-stage hormone-positive breast cancer is the standard of care. However, decisions based on genomic testing results are predicated on the assumption that patients receive endocrine treatment. We sought to investigate racial differences in genomic testing and adjuvant treatment in breast cancer.MethodsA retrospective, population-based hospital registry study using the National Cancer Database. Participants included women with stages I –II, ER + breast cancer between 2010 and 2014. Sociodemographic factors were analyzed. Primary outcomes were the utilization of genomi...
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Revisiting the internal mammaries as recipient vessels in breast reconstruction: considerations in current practice
ConclusionGiven overall trends in breast reconstruction and the sometimes-elevated cardiac risk profiles of our patients, the authors recommend risk stratification of all patients using the proposed Breast Reconstruction Internal Mammary Assessment (BRIMA) scoring system and consideration of left internal mammary artery preservation in select cases. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Letter to the editor with regard to the manuscript titled “Circulating tumour cell enumeration does not correlate with Miller–Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy”
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Luminal subtypes and response to neoadjuvant chemotherapy for hormone receptor-positive HER2-negative patients
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Nomograms for prediction of overall and cancer-specific survival in young breast cancer
AbstractPurposeTo assess the prognostic risk factors and establish prognostic nomograms based on lymph node ratio (LNR) to predict the survival of young patients with breast cancer (BC).MethodsPatients aged  
Source: Breast Cancer Research and Treatment - September 4, 2020 Category: Cancer & Oncology Source Type: research

Development and validation of prognostic gene signature for basal-like breast cancer and high-grade serous ovarian cancer
ConclusionA gene signature was identified to predict recurrence in BLBC and HGSOC patients. With further validation, this signature may provide an additional prognostic tool for clinicians to better manage BLBC, many of which are triple-negative and HGSOC patients who are currently difficult to treat. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 2, 2020 Category: Cancer & Oncology Source Type: research

Real-world effectiveness of dual HER2 blockade with pertuzumab and trastuzumab for neoadjuvant treatment of HER2-positive early breast cancer (The NEOPETRA Study)
AbstractPurposeNeoadjuvant clinical trials with dual HER2 blockade with pertuzumab and trastuzumab plus chemotherapy demonstrated high rates of pathological complete response (pCR) in HER2-positive early breast cancer (BC). We investigated whether the benefit on pCR seen in clinical trials is confirmed in a real-world setting.MethodsMulticenter, retrospective study in patients with HER2-positive early BC receiving neoadjuvant treatment with pertuzumab and trastuzumab in routine clinical practice (n = 243). The primary endpoint was total pCR (tpCR) (ypT0/is ypN0).ResultsA total of 243 evaluable patients were i...
Source: Breast Cancer Research and Treatment - September 2, 2020 Category: Cancer & Oncology Source Type: research

Risk factors for inflammatory and non-inflammatory breast cancer in North Africa
ConclusionsWe identified novel risk factors for IBC and non-IBC, some of which preferentially increased risk of IBC compared to non-IBC. Upon confirmation, these findings could help illuminate the etiology and aid in prevention of this aggressive cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 2, 2020 Category: Cancer & Oncology Source Type: research

CDH2 /N-cadherin and early diagnosis of invasion in patients with ductal carcinoma in situ
AbstractPurposeThis proof-of-concept study investigates gene expression in core needle biopsies (CNB) to predict whether individuals diagnosed with ductal carcinoma in situ (DCIS) on CNB were affected by invasion at the time of diagnosis.MethodsUsing a QuantiGene Plex 2.0 assay, 14 gene expression profiling was performed in 303 breast tissue samples. Preoperative diagnostic performance of a gene was measured by area under receiver-operating characteristic curve (AUC) with 95% confidence interval (CI). The gene mRNA positivity cutoff was computed using Gaussian mixture model (GMM); protein expression was measured by immunoh...
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Clinical decision trees support systematic evaluation of multidisciplinary team recommendations
ConclusionBoth the availability of data in patient records essential for guideline-based recommendations and the reporting of possible treatment alternatives of the investigated CDTs were low. To meet EUSOMA ’s requirements, information that is supposed to be implicitly known must be explicated by MDTs. Moreover, MDTs have to adhere to clear definitions of data-items in their reporting. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Endocrine treatment and incidence of relapse in women with oestrogen receptor-positive breast cancer in Europe: a population-based study
ConclusionsER-positive BC patients in Europe are increasingly prescribed ET but between-country disparities persist. Older women and women with severe comorbidity less frequently receive ET. ET omission and severe comorbidity independently predict early disease relapse. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Obesity and related conditions and risk of inflammatory breast cancer: a nested case –control study
AbstractPurposeInflammatory breast cancer (IBC) is a rare, poorly understood and aggressive tumor. We extended prior findings linking high body mass index (BMI) to substantial increased IBC risk by examining BMI associations before and after adjustment for well-characterized comorbidities using medical record data for diabetes, insulin resistance, and disturbances of cholesterol metabolism in a general community healthcare setting.MethodsWe identified 247 incident IBC cases diagnosed at Kaiser Permanente Northern California between 2005 and 2017 and 2470 controls matched 10:1 on birth year and geographic area and with &thi...
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy
ConclusionTP53 LOF mutations and initial Ki67 status in HER2-positive breast cancer are predictive of pCR status after HER2-targeted NACT. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Dynamic contrast-enhanced magnetic resonance imaging for risk-stratified screening in women with BRCA mutations or high familial risk for breast cancer: are we there yet?
ConclusionsAs breast MRI is recommended as part of an intensified screening program in addition to mammography for high-risk women, it important that health care providers understand the benefits and limitations of this screening modality for high-risk women, as well as areas for further investigation. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Patient preferences for locoregional therapy in early-stage breast cancer
ConclusionsPatient preference is difficult to define and measure, and heterogeneity across studies renders direct comparison difficult. Future work is needed to define women ’s risk-thresholds for certain treatments, delve into the psychological factors that direct their decisions, and understand how patients’ valuations of risk interact with society’s. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Cost-effectiveness analyses demonstrate that observation is superior to sentinel lymph node biopsy for postmenopausal women with HR  + breast cancer and negative axillary ultrasound
ConclusionConsidering both cost and effectiveness, observation is superior to SLNB in postmenopausal women with cT1-T2 N0, HR+/HER2− breast cancer and negative AUS. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Differential prognostic value of positive  HER2 status determined by immunohistochemistry or fluorescence in situ hybridization in breast cancer
ConclusionOur results indicate that prognostic information in HER2 positive breast cancer also depends on the methodology of how positivity was determined. In our cohort, FISH was superior to IHC based positive HER2 status. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin
ConclusionsTRAF4 was a novel substrate of SIAH1 and prevented SIAH1-mediated β-catenin degradation, which explains the protective effect of TRAF4 on β-catenin during cell stress and links TRAF4 to chemotherapy resistance in tumors. These findings implicated a novel pathway for the oncogenic function of TRAF4. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Racial differences in the relationship between surgical choice and subsequent patient-reported satisfaction outcomes among women with early-stage hormone-positive breast cancer
ConclusionDespite the high prevalence of mastectomy among Black women with early-stage, HR-positive breast cancer, this population is more likely to report lower levels of patient satisfaction compared to patients receiving BCT. These findings suggest there may be potential racial differences in the psychosocial consequences of surgical choice. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients
ConclusionsOur results suggested that BMI and AI drug (letrozole versus anastrozole) were clinical predictors of arthralgia, while genetic variants rs4775936, rs9322336, rs2234693, and rs9340799 were genetic predictors of AI-induced arthralgia. Significantly, rs4775936 was also a predictor of discontinuation of therapy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research

Patient-reported acute fatigue in elderly breast cancer patients treated with and without regional nodal radiation
AbstractPurposeAlthough regional nodal irradiation (RNI) improves outcomes in breast cancer (BC) patients, it is associated with increased toxicity. Therefore, controversy still exists surrounding its indications. The purpose of this study was to evaluate and compare patient-reported acute fatigue in elderly BC patients with and without regional nodal radiation (RNI).MethodsElderly breast cancer patients ( ≥ 65 years) treated with adjuvant radiotherapy (RT) between 2012 and 2017 were identified from a prospective database. The validated Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire, which...
Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research