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Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia
ConclusionOur data provide insight into the genetics of breast cancer in this understudied group and suggest the need for modifying genetic testing guidelines for this population with a much younger age at diagnosis and more limited resources compared with Caucasian populations. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Prognostic values of cancer associated macrophage-like cells (CAML) enumeration in metastatic breast cancer
AbstractPurposeCirculating cancer associated macrophage-like cells (CAMLs) have been detected in the peripheral blood of patients with solid tumors including breast cancer. However, the prognostic relevance of CAMLs in metastatic breast cancer (MBC) has not been evaluated. In the present study, we aimed to measure CAMLs and circulating tumor cells (CTCs) at baseline and examine their prognostic value in patients with MBC.MethodsPeripheral blood samples from 127 MBC patients were collected at baseline before starting a new treatment. The detection and enumeration of CAMLs and CTCs in 7.5  ml whole blood were performed ...
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Oncologists ’ influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer?
ConclusionsClinical algorithms have markedly reduced variation in chemotherapy use across oncologists. Oncologists ’ large influence on variation in RS use suggests that they variably seek tumor profiling to inform treatment decisions. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Does biomarker information impact breast cancer patients ’ preferences and physician recommendation for adjuvant chemotherapy?
ConclusionsInformation about a positive biomarker indicating increased benefit and toxicity from additional chemotherapy did not change many participants ’ preferred treatment. The majority preferred the most effective course in both scenarios. Similarly, most investigators discounted increased toxicity and valued increased benefit. Parent Trial Registration: NCT00433511 (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Mammographic breast density decreases after bariatric surgery
AbstractPurposeBreast density (BD), an important risk factor for breast cancer, can change over time in some women, but the underlying mechanism is unclear. Very little is known about the impact of surgical weight loss on BD. Our hypothesis is that weight loss after bariatric surgery is associated with a significant and favorable change in mammographic BD.MethodsWe identified 1097 women 40  years of age or older who underwent gastric bypass or sleeve gastrectomy at our institution from 2010 to 2014. Women who did not have either pre- and post-bariatric surgery mammograms performed at our institution were excluded; 110...
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Increasing utilization of regional nodal irradiation in elderly node-positive women and declining emphasis on demographic factors
ConclusionsThere was an increase in utilization of RNI for elderly patients from 2004 to 2013. In more recent years, the primary factors associated with receipt of RNI were tumor related with declining importance of demographic factors. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Impact of the 21-gene recurrence score on outcome in patients with invasive lobular carcinoma of the breast
ConclusionFor patients with ER-positive ILC, 8% were in the high-risk and 72% were in the intermediate-risk groups as per the TAILORx RS cutoffs. In the high-risk group, the RS predicted a lower 5-year BCSS. Adjuvant chemotherapy did not seem to confer a survival benefit for either the intermediate- or the high-risk cohorts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Predictive factors on outcomes in metaplastic breast cancer
ConclusionsThis study represents among the largest institutional experiences in the outcomes of MBC. At this time, there does not appear to be a clear histologic subset of MBC which has significantly different clinical outcomes from the other subtypes. Although limited in its sample size, this study shows RT remains important in local –regional control. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

A pilot study of cabergoline for the treatment of metastatic breast cancer
ConclusionCabergoline was well tolerated, and while the ORR was low, a small subset of patients experienced extended disease control. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Different outcome in node-positive breast cancer patients found by axillary ultrasound or sentinel node procedure
We examined whether relevant differences exist between these patients to determine if the conclusions of the ACOSOG Z0011 trial are applicable to UGLNB-positive patients.MethodsPatients diagnosed with invasive breast cancer in the Netherlands between January 2008 and December 2014 were selected from the Netherlands Cancer Registry.ResultsA total of 11,820 cases were included: 9149 cases in the SLNB group and 2671 in the UGLNB group. Multivariate analyses showed that UGLNB-positive patients were older (p 
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Preoperative paravertebral blocks for the management of acute pain following mastectomy: a cost-effectiveness analysis
ConclusionOver a broad range of probabilities, PPVB in mastectomy reduces postoperative pain at an acceptable incremental cost compared to GA. Commercial payers should be persuaded to reimburse this technique based on convincing evidence of cost-effectiveness. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Risk of mortality of node-negative, ER/PR/HER2 breast cancer subtypes in T1, T2, and T3 tumors
ConclusionsT1a tumors have the same risk of mortality regardless of ER/PR/HER2 subtype, and ER and PR negativity plays a stronger role in survival than HER2 positivity for tumors of all size. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Improved survival for sequentially as opposed to concurrently delivered neoadjuvant chemotherapy in non-metastatic breast cancer
ConclusionsNo differences were observed between the two treatment arms with respect to pCR rate, but the sequentially delivered chemotherapy outperformed the triplet combination chemotherapy in terms of survival, despite a lower cumulative dose per agent. GOV nr NCT00314977. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

A step-by-step oncoplastic breast conservation surgical atlas of reproducible dissection techniques and anatomically ideal incision placement
ConclusionAdoption of OPS techniques utilizing an anatomically ideal incision in breast conservation surgery is a feasible and reproducible practice for breast surgeons. Application of these techniques results in maintained optimal shape, size, and contour without the typical overlying skin envelope scars. OPS techniques performed under the skin envelope result in expected OPS oncologic and aesthetic outcomes with the addition of the resulting scar(s) in anatomically discrete position(s). (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Detection of BRCA1 gross rearrangements by droplet digital PCR
ConclusionDroplet digital PCR is a reliable tool for the detection of large genomic rearrangements. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

In response to “outcomes of patients with inflammatory breast cancer treated by breast conserving surgery”: the argument against breast conservation and sentinel lymph node biopsy in IBC
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Whither surgical quality assurance of breast cancer surgery (surgical margins and local recurrence) after paterson
This article assesses whether Kennedy ’s recommendations apply to the UK as a whole and how to address these issues. New GMC advice on consent and newer nonevidenced innovations in immediate reconstruction have altered the level of informed consent required. Patients deserve a better understanding of the issues of oncological versus c osmetic outcomes on which to base their decisions. Involvement of the whole multidisciplinary team including Oncologists is necessary in surgical planning. Failure to obtain clear microscopic margins at mastectomy leads to an increased local recurrence, yet has received little attention...
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

From clinical trials to clinical practice: outcome of NSABP-B27 neoadjuvant chemotherapy regimen for high-risk early-stage breast cancer
This study evaluated the efficacy and safety of NSABP-B27 regimen in high-risk patients in daily clinical practice.MethodsPatients ’ medical records and hospital database were searched for all consecutive patients treated at our institution for breast cancer using neoadjuvant NSABP-B27 chemotherapy regimen. Chemotherapy was given at standard doses and schedule as originally reported in the NSABP-B27.Results346 female patients (median age 51  years) were treated using this regimen. Majority had high-risk features including larger tumor size (>4  cm in 68.5%), positive axillary lymph nodes (78.3%), and Gra...
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Response Letter
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Pro-apoptotic effect of Δ2-TGZ in “claudin-1-low” triple-negative breast cancer cells: involvement of claudin-1
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 15, 2017 Category: Cancer & Oncology Source Type: research

Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer
ConclusionsIn early-stage TNBC, nodal involvement, TILs, and receipt of adjuvant chemotherapy were independently associated with IDFS and OS. In systemically untreated TNBC, TILs remained prognostic and the risk of recurrence or death was substantial, even for T1N0 disease. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2017 Category: Cancer & Oncology Source Type: research

Does levonorgestrel-releasing intrauterine system increase breast cancer risk in peri-menopausal women? An HMO perspective
AbstractPurposeTo evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk.MethodsA cohort of all Maccabi Healthcare Services (MHS) female members aged 40 –50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as “cases,” and 2 age-matched non-users as “controls.” Exclusion criteria included: prior BC diagnosis, prior (5 years pre-study) and subsequent treatment with other female hormones or prophylactic tamoxifen. Invasiv e tumors were characterized by treatments received (chemotherapy, hormonal therapy,...
Source: Breast Cancer Research and Treatment - September 14, 2017 Category: Cancer & Oncology Source Type: research

Molecular profile of atypical hyperplasia of the breast
ConclusionsThis molecular profile should help clarify the genomic characteristics and malignant predisposition of AH, and aid in the identification of new targets for the prevention of breast cancer (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2017 Category: Cancer & Oncology Source Type: research

Weight gain in hormone receptor-positive (HR+) early-stage breast cancer: is it menopausal status or something else?
ConclusionThe association of weight loss prior to ET and subsequent substantial weight gain during ET warrants further investigation. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2017 Category: Cancer & Oncology Source Type: research

Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients
ConclusionsWe identified and replicated a novel gene,ETFB, strongly associated with chronic AIC independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction. Although experimental verification and further studies in larger patient cohorts are required to confirm our finding, we demonstrated that exome array data analysis represents a valuable strategy to identify novel genes contributing to the susceptibility to chronic AIC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 14, 2017 Category: Cancer & Oncology Source Type: research

Highly sensitive detection of ESR1 mutations in cell-free DNA from patients with metastatic breast cancer using molecular barcode sequencing
AbstractPurposeWe aimed to develop a highly sensitive method to detectESR1 mutations in cell-free DNA (cfDNA) using next-generation sequencing with molecular barcode (MB –NGS) targeting the hotspot segment (c.1600–1713).MethodsThe sensitivity of MB –NGS was tested using serially dilutedESR1 mutant DNA and then cfDNA samples from 34 patients with metastatic breast cancer were analyzed with MB –NGS. The results of MB–NGS were validated in comparison with conventional NGS and droplet digital PCR (ddPCR).ResultsMB –NGS showed a higher sensitivity (0.1%) than NGS without barcode (1%) by reduc...
Source: Breast Cancer Research and Treatment - September 13, 2017 Category: Cancer & Oncology Source Type: research

Tumour-infiltrating lymphocytes (TILs)-related genomic signature predicts chemotherapy response in breast cancer
AbstractPurpose The present study evaluated whether morphological-measured stromal and intra-tumour tumour-infiltrating lymphocytes (TILs) levels were associated with gene expression profiles, and whether TILs-associated genomic signature (GS) could be used to predict clinical outcomes and response to therapies in several breast cancer subtypes.MethodsWe retrospectively evaluated haematoxylin eosin (HE)-TILs levels and gene expression profiling data from 40 patients with primary breast cancer and extracted the 22 overexpressed genes in cases with high TILs scores as the TILs-GS. The TILs-GS were compared with breast cancer...
Source: Breast Cancer Research and Treatment - September 13, 2017 Category: Cancer & Oncology Source Type: research

Take care of your neighborhood
ConclusionsAmong an urban population of predominantly insured women with high rates of advanced breast cancer at diagnosis, personal factors and fear were cited as the greatest barriers to breast cancer screening. Educational intervention by CHWs showed a positive impact on respondents ’ perceptions regarding mammogram safety and efficacy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2017 Category: Cancer & Oncology Source Type: research

A frameshift mutation in BRCA1 leads to hereditary breast and ovarian cancer in one part of a family and to familial pancreatic cancer in another
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2017 Category: Cancer & Oncology Source Type: research

Healthcare utilization, Medicare spending, and sources of patient distress identified during implementation of a lay navigation program for older patients with breast cancer
ConclusionsLay navigation reduced healthcare utilization in older adults with breast cancer, with the greatest impact observed in early-stage breast cancer patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 12, 2017 Category: Cancer & Oncology Source Type: research

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients
ConclusionSevere depression scores are more common in DCIS patients, despite their excellent prognosis. These results suggest that further improvement of patient education and effective patient doctor communication about the prognostic differences between patients with DCIS and invasive breast cancer is still highly needed. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 11, 2017 Category: Cancer & Oncology Source Type: research

Durable complete response in HER2-positive breast cancer: a multicenter retrospective analysis
ConclusionWe found that some patients showed no evidence of disease after the interruption of trastuzumab therapy. Discontinuation of maintenance trastuzumab in this patient population after a limited time should be explored cautiously while awaiting a global collaborative effort for a randomized trial. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 11, 2017 Category: Cancer & Oncology Source Type: research

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research
ConclusionThese features are compared with other published genotype and phenotype information in a user-friendly reference table to help guide selection of the most appropriate models for in vitro and in vivo studies, and as a framework for classifying new patient-derived cancer cell lines and xenografts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 9, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 7, 2017 Category: Cancer & Oncology Source Type: research

Socioeconomic status and breast cancer treatment
ConclusionsOur results indicate that SES disparities in the receipt of treatments for incident breast cancer are both pervasive and substantial. These disparities remained despite women ’s geographic area of residence and extent of disease, suggesting important gaps in access to effective breast cancer care. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 7, 2017 Category: Cancer & Oncology Source Type: research

An observational study investigating failure of primary endocrine therapy for operable breast cancer in the elderly
AbstractBackgroundElderly patients are more likely to have oestrogen receptor positive cancers that can be treated without surgery with primary endocrine therapy (PET). Few studies have sought to identify predictors of failure of PET and so the aim of this study was to evaluate treatment failures in elderly breast cancer patients treated with PET and to determine predictors of failure.MethodsA retrospective observational study was performed on consecutive patients with ER-positive early stage breast cancer treated with PET between 2005 and 2015 in the three breast units in the North East of England. The primary outcome mea...
Source: Breast Cancer Research and Treatment - September 6, 2017 Category: Cancer & Oncology Source Type: research

Second opinion strategies in breast pathology: a decision analysis addressing over-treatment, under-treatment, and care costs
ConclusionsSecond opinion strategies could lower overall care costs while reducing both over- and under-treatment. The most accurate cost-saving strategy required second opinions for initial diagnoses of invasive cancer, DCIS, or atypia. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 6, 2017 Category: Cancer & Oncology Source Type: research

Outcome after neoadjuvant chemotherapy in estrogen receptor-positive and progesterone receptor-negative breast cancer patients: a pooled analysis of individual patient data from ten prospectively randomized controlled neoadjuvant trials
AbstractPurposeThe estrogen receptor (ER) is involved in control of progesterone receptor (PgR) expression and lack of PgR may be also a surrogate of altered growth factor signaling. The aim of this study was therefore to investigate PgR expression as predictive factor for response to neoadjuvant therapy and long-term outcome.MethodsFive thousand and six hundred and thirteen patients with primary breast cancer and positive ER expression from ten German neoadjuvant trials of anthracycline and taxane-based chemotherapy were included. Pathologic complete response (pCR), disease-free survival (DFS), distant disease-free surviv...
Source: Breast Cancer Research and Treatment - September 5, 2017 Category: Cancer & Oncology Source Type: research

Predictive role of loco-regional radiotherapy among metastatic breast cancer patients who had undergone primary tumor surgery
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 5, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 4, 2017 Category: Cancer & Oncology Source Type: research

Association of the severity of diabetes-related complications with stage of breast cancer at diagnosis among elderly women with pre-existing diabetes
ConclusionThe increased likelihood of having advanced-stage BC at diagnosis associated with severity of diabetes-related complications appears to be mediated by lower rates of breast cancer screening among elderly women with pre-existing diabetes complications. Therefore, reducing disparity in receiving breast cancer screening among elderly women with diabetes may reduce the risk of advanced-stage breast cancer diagnosis. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 2, 2017 Category: Cancer & Oncology Source Type: research

Inverse  relationship between Ki67 and survival in early luminal breast cancer: confirmation in a multivariate analysis
ConclusionsPrognosis of luminal breast carcinoma can be predicted using Ki67 as a continuous variable and a standard cut-off value of 14%. Information about the specimen type used to determine ki67 should be recorded in the pathological report. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - September 1, 2017 Category: Cancer & Oncology Source Type: research

Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment
ConclusionsWomen withBRCA1/2 mutations indicated strong preferences for breast cancer risk reduction and maintaining fertility. The expressed desire to have a safe chemoprevention drug available to them was not met by current chemoprevention options. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

Predictors of distress in female breast cancer survivors: a systematic review
ConclusionsThis review established a set of evidence-based predictors that can be used to help identify women at higher risk of experiencing distress following completion of primary breast cancer treatment. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes
ConclusionOur findings suggest that associations of mammographic density with breast cancer risk differ by tumor aggressiveness. While there was no strong evidence that these associations differed by menopausal status or hormone therapy, they did appear more prominent among current estrogen+progesterone users. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review
ConclusionsWe confirm that PLCIS in isolation is indeed a rare entity, further contributing to the difficulty in determining the actual risk conferred by this lesion. Long-term follow-up data on larger cohorts are needed to define standardized management and outcomes for patients with PLCIS. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

The financial impact and drivers of hospital charges in contralateral prophylactic mastectomy and reconstruction: a Nationwide Inpatient Sample hospital analysis
This study aims to identify factors affecting charges in those undergoing CPM and reconstruction.MethodsAnalysis of the Healthcare Cost and Utilization Project National Inpatient Sample was undertaken (2009 –2012), identifying women aged ≥18 with unilateral breast cancer undergoing unilateral mastectomy with CPM and immediate breast reconstruction (IBR) (CPM group), in addition to unilateral mastectomy and IBR alone (UM group). Generalized linear modeling with gamma regression and a log-link functi on provided mean marginal hospital charge (MMHC) estimates associated with the presence or absence of patient, hospit...
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

COX2 induction: a mechanism of endocrine breast cancer resistance?
ConclusionOur results indicate that one of the pharmacological effects to aromatase inhibitors (e.g., exemestane) involves the activation of the inflammatory pathway via release of PGE2. Further in vitro mechanistic and in vivo translational studies designed to elucidate the role of this newly discovered effect are now warranted. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

The efficacy of lymphaticovenular anastomosis in breast cancer-related lymphedema
ConclusionTreatment with LVAs is effective in reducing arm volume difference in patients suffering from BCRL. Although no complete reduction of the edema was achieved at 12-month follow-up, the procedure significantly increased the patients ’ QoL. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research

Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - August 3, 2017 Category: Cancer & Oncology Source Type: research