Concurrent risk-reduction surgery in patients with increased lifetime risk for breast and ovarian cancer: an analysis of the National Surgical Quality Improvement Program (NSQIP) database
AbstractBackgroundPatients with genetic susceptibility to breast and ovarian cancer are eligible for risk-reduction surgery. Surgical morbidity of risk-reduction mastectomy (RRM) with concurrent bilateral salpingo-oophorectomy (BSO) is unknown. Outcomes in these patients were compared to patients undergoing RRM without BSO using a large multi-institutional database.MethodsA retrospective cohort analysis was conducted using the American College of Surgeon ’s National Surgical Quality Improvement Program (NSQIP) 2007–2016 datasets, comparing postoperative morbidity between patients undergoing RRM with patients un...
Source: Breast Cancer Research and Treatment - July 13, 2018 Category: Cancer & Oncology Source Type: research

Impact of high-deductible insurance on adjuvant hormonal therapy use in breast cancer
ConclusionWe did not detect significant changes in AHT use after the HDHP switch. Findings might be related to modest increases in overall AHT OOP costs, the availability of low-cost generic tamoxifen, and patient awareness that AHT can prolong life and health. Minimizing OOP cost increases for essential medications might represent a feasible approach for maintaining medication adherence among HDHP members with incident breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 13, 2018 Category: Cancer & Oncology Source Type: research

Palbociclib in highly pretreated metastatic ER-positive HER2-negative breast cancer
ConclusionsPalbociclib in combination with endocrine therapy shows an unexpectedly high CBR and favorable safety profile in heavily pretreated endocrine-resistant estrogen receptor-positive, HER2-negative MBC patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 13, 2018 Category: Cancer & Oncology Source Type: research

Predictors of surveillance mammography outcomes in women with a personal history of breast cancer
This study was HIPAA compliant and IRB approved. We performed an electronic medical record review for a cohort of women with American Joint Committee on Cancer (AJCC) Stage I or II invasive breast cancer treated with breast conservation therapy who developed subsequent in-breast treatment recurrence (IBTR) or contralateral breast cancer (CBC). Poor surveillance outcome was defined as second breast cancer not detected by surveillance mammography, including interval cancers (diagnosed within 365  days of surveillance mammogram with negative results) and clinically detected cancers (diagnosed without a surveillance mammo...
Source: Breast Cancer Research and Treatment - July 13, 2018 Category: Cancer & Oncology Source Type: research

A phase II study evaluating the efficacy of zoledronic acid in prevention of aromatase inhibitor-associated musculoskeletal symptoms: the ZAP trial
AbstractPurposeAromatase inhibitor-associated musculoskeletal symptoms (AIMSS) are common adverse events of AIs often leading to drug discontinuation. We initiated a prospective clinical trial to evaluate whether bisphosphonates are associated with reduced incidence of AIMSS.MethodsIn the single-arm trial, the Zoledronic Acid Prophylaxis (ZAP) trial, we compared the incidence of AIMSS against historical controls from the Exemestane and Letrozole Pharmacogenomics (ELPh) trial. Eligible women were postmenopausal with stage 0-III breast cancer planning to receive adjuvant AIs. AIMSS was assessed using the Health Assessment Qu...
Source: Breast Cancer Research and Treatment - July 13, 2018 Category: Cancer & Oncology Source Type: research

Personal and clinical social support and adherence to adjuvant endocrine therapy among hormone receptor-positive breast cancer patients in an integrated health care system
This study included 3382 women from the Pathways Study diagnosed from 2005 to 2013 with stages I –III hormone receptor-positive BC and who responded to the Medical Outcomes Study Social Support and Interpersonal Processes of Care surveys, approximately 2 months post-diagnosis. We used logistic regression to evaluate associations between tertiles of social support and non-initiation (
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Physician peer group characteristics and timeliness of breast cancer surgery
ConclusionsThe likelihood of surgical delay varied substantially across physician peer groups and was associated with provider density and patient racial composition. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Understanding racial/ethnic differences in breast cancer-related physical well-being: the role of patient –provider interactions
AbstractPurposeRacial/ethnic differences in cancer symptom burden are well documented, but limited research has evaluated modifiable factors underlying these differences. Our objective was to examine the role of patient –provider interactions to help explain the relationship between race/ethnicity and cancer-specific physical well-being (PWB) among women with breast cancer.MethodsThe Pathways Study is a prospective cohort study of 4505 women diagnosed with breast cancer at Kaiser Permanente Northern California between 2006 and 2013. Our analysis included white, black, Hispanic, and Asian participants who completed ba...
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment
ConclusionsThere is good correlation between the somatic mutations and CNA called using archived blood or normal breast tissue as germline reference material. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Effect of eribulin on patients with metastatic breast cancer: multicenter retrospective observational study in Taiwan
AbstractPurposeThe aim of this study was to confirm the therapeutic role of eribulin on Taiwanese women with metastatic breast cancer.MethodsThis retrospective study examined 449 females who received eribulin between March 2014 and June 2017 at 14 hospitals in Taiwan for treatment of locally advanced or metastatic breast cancer.ResultsThe survival rate at 24  months was 57.2% (95% CI 51.0–62.9%) and the median time to treatment failure (TTF) was 3.91 months (95% CI 3.45–3.94). A total of 175 patients (40.1%) received eribulin for fewer than 90 days and the others received it for 90 days or m...
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

A randomized, double-blind, phase 2 study of ruxolitinib or placebo in combination with capecitabine in patients with advanced HER2-negative breast cancer and elevated C-reactive protein, a marker of systemic inflammation
ConclusionsThe addition of ruxolitinib to capecitabine for patients with advanced breast cancer and high systemic inflammation was generally tolerable; ORR was numerically greater, a more favorable change in HRQoL was observed, but neither OS nor PFS was improved compared with placebo plus capecitabine. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Uptake of breast cancer preventive therapy in the UK: results from a multicentre prospective survey and qualitative interviews
ConclusionsUptake of tamoxifen is low in clinical practice. There were no socio-demographic differences in uptake, suggesting that the introduction of breast cancer preventive therapy is unlikely to create socioeconomic inequalities in cancer incidence. Women ’s decision-making was influenced by familial priorities, particularly having children. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Association of reproductive history with breast tissue characteristics and receptor status in the normal breast
ConclusionReproductive risk factors significantly influence the epithelial tissue compartment and expression of hormone receptors in later life. These changes remain after menopause. This study provides deeper insights of the biological mechanisms by which reproductive history influences epithelial area and expression of hormone receptors, and as a consequence the risk of breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis
ConclusionOur study suggests that MCP-1 mediated pathways could be potential therapeutic targets for the treatment of TNBC, and could reduce cancer health disparities. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Response rates and pathologic complete response by breast cancer molecular subtype following neoadjuvant chemotherapy
ConclusionsAssessing nearly 14,000 women from a contemporary United States database, this is the largest known study examining the relationship between response to NC and molecular subtype. Women with luminal A disease are the least likely to undergo pCR, with the highest rates in Her2 disease. Degree of response is associated with OS, especially in luminal B, Her2, and TN patients. Despite the comparatively higher likelihood of achieving pCR in TN cases, this subgroup may still experience a survival detriment, which has implications for an ongoing national randomized trial. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Use of dual mTOR inhibitor MLN0128 against everolimus-resistant breast cancer
ConclusionAmong the many signaling transduction pathways, which are altered post everolimus resistance, targeting dual mTORC1/2 is a possible option for patients who have recurrent disease from previous everolimus treatment. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

The relationship between tumour size, nodal status and distant metastases: on the origins of breast cancer
ConclusionsThe relationship between tumour size, lymph node status and distant metastases in patients with invasive breast cancer is not linear. This calls into question the conventional model that the capacity for a primary breast tumour to metastasize increases as the tumour enlarges. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Impact of port site scar on perception of patients with breast cancer: patient-reported outcomes
ConclusionMost patients are conscious of their port scars and if offered the choice choose placement in the arm rather than the chest. Upper extremity port placement should be further explored as an alternative approach for patients with breast cancer to improve port scar consciousness. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Pre-diagnostic changes in body mass index and mortality among breast cancer patients
ConclusionWeight gain affects overall mortality after breast cancer but clinical prognostic factors largely eliminate the association. Using trajectories of weight changes did not improve the predictive value compared to a single measure of BMI. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Health-related quality of life of postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treated with ribociclib  + letrozole: results from MONALEESA-2
ConclusionsHRQoL was consistently maintained from baseline in postmenopausal women with HR+, HER2 − advanced breast cancer receiving ribociclib plus letrozole and was similar to that observed in the placebo plus letrozole arm. Together with the improved clinical efficacy and manageable safety profile, these PRO results provide additional support for the benefit of ribociclib plus letrozole in this patient population. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Bilateral mastectomies: can a co-surgeon technique offer improvements over the single-surgeon method?
AbstractPurposeBilateral mastectomy (BM) is traditionally performed using a single-surgeon (SS) technique (SST); a co-surgeon (CS) technique (CST), where each attending surgeon concurrently performs a unilateral mastectomy, offers an alternative approach. We sought to compare the CST and SST for BM with respect to operative times and complications.MethodsPatients undergoing BM without reconstruction at our institution between 2005 and 2015 were identified using operative caselogs and stratified into CS- and SS-cohorts. Operative time (OT; incision to closure) was calculated. Patient age, cancer presence/stage, hormone rece...
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies
ConclusionsAsian HRT users had a higher risk of breast cancer than western HRT users. Both ET and EPT were significantly associated with the risk of all breast cancer histological types and ER-positive breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
ConclusionsKLHL7 appears to play an important role in BC progression. High KLHL7 protein expression identified a subgroup of BC with aggressive behaviour and provided independent prognostic information. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

Prediction of breast cancer risk with volatile biomarkers in breath
ConclusionAnalysis of breath VOC samples collected with ultra-clean balloons detected biomarkers that accurately predicted risk of breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Radial scar on image-guided breast biopsy: is surgical excision necessary?
ConclusionsWe found a very low upgrade rate to breast cancer when RS was found on CNB with or without associated HRL. Our results are consistent with other reported series. Our data do not support surgical excision for RS but rather close clinical follow-up for patients with RS on CNB. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Prognostic impact of surgery for early-stage invasive breast cancer on breast cancer-specific survival, overall survival, and recurrence risk: a population-based analysis
ConclusionsAmong patients with early-stage breast cancer, clinical outcomes more than 10  years after diagnosis did not differ between the primary treatment options BCT + RT, MT + RT versus MT alone after full adjustment. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Thirty-day postoperative morbidity and mortality in elderly women with breast cancer: an analysis of the NSQIP database
We describe the postoperative complication rates of elderly ( ≥ 70 years) women with breast cancer and compare them with young (40–69 years) women.MethodsData were extracted from the National Surgical Quality Improvement Program database (2004 –2014). We included women with invasive breast cancer who underwent surgery. Outcomes were 30-day postoperative morbidity and mortality (complications), which were compared between young and elderly women. Morbidity was categorized using the Surgical Risk Preoperative Assessment System (SURPAS) c lusters.ResultsWe identified 100,037 women of w...
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Health-related quality of life of Iranian breast cancer patients: a meta-analysis and systematic review
ConclusionAccording to the results of the study, a moderate level of quality of life in women with breast cancer was indicated. Therefore, the use of multidimensional approaches can improve their quality of life. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Breast screening and the parallel progression model of cancer
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Comparison of breast cancers detected in the Verona screening program following transition to digital breast tomosynthesis screening with cancers detected at digital mammography screening
AbstractBackgroundThe Verona population-based breast cancer (BC) screening program provides biennial mammography to women aged 50 –69 years. Based on emerging evidence of enhanced detection, the program transitioned to digital breast tomosynthesis (DBT) screening.MethodsThis is a prospective pilot evaluation of DBT with synthesised 2D mammography screening implemented during April 2015 –March 2017; the rate and characteristics of cancers detected at DBT screening were compared with those detected at the preceding digital mammography (DM) screening round (April 2013–March 2015) in the same screening p...
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Pre-operative progesterone benefits operable breast cancer patients by modulating surgical stress
ConclusionsOur study suggests that pre-operative exposure to progesterone favourably modulates the effect of surgical stress, and this might underlie its beneficial effect when administered prior to surgery. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Receptor conversion in breast cancer patients with liver metastases after hepatectomy might affect survival
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

A parallel model for breast cancer metastasis
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 13, 2018 Category: Cancer & Oncology Source Type: research

Exercise and weight loss interventions and miRNA expression in women with breast cancer
AbstractPurposeObesity and weight gain are associated with comorbidities including a higher risk of tumor recurrence and cancer-related deaths among breast cancer (BC) survivors; however, the underlying mechanisms linking obesity and cancer are poorly understood. Given the lack of clinically validated BC biomarkers, obesity and weight-loss studies utilize serum biomarkers as the intermediary outcomes of tumor recurrence. Studies have indicated microRNAs (miRNA)s are reliable biomarkers for cancer. We hypothesized that miRNA expression correlates with obesity and weight loss amongst BC survivors. This would yield insight in...
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Mammographic non-dense area and breast cancer risk in postmenopausal women: a causal inference approach in a case –control study
This study utilizes data from a population-based case –control study conducted in Greater Vancouver, British Columbia, with 477 female postmenopausal breast cancer cases and 588 female postmenopausal controls. MD measures were determined from digitized screening mammograms using computer-assisted software (Cumulus). Marginal odds ratios were estimate d by inverse-probability weighting using a causal diagram for confounder selection. Akaike information criteria and receiver operating characteristic curves were used to assess the goodness of fit and predictive power of unconditional logistic models containing MD parame...
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Acupuncture for breast cancer-related lymphedema: a randomized controlled trial
ConclusionsOur acupuncture protocol appeared to be safe and well tolerated. However, it did not significantly reduce BCRL in pretreated patients receiving concurrent lymphedema treatment. This regimen does not improve upon conventional lymphedema treatment for breast cancer survivors with persistent BCRL. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Dose-dependent effect of mammographic breast density on the risk of contralateral breast cancer
ConclusionBreast density is an independent and significant risk factor for development of contralateral breast cancer. This risk factor should contribute to clinical decision making. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Preoperative breast MRI and mortality in older women with breast cancer
ConclusionOur findings of no breast cancer-specific or all-cause mortality benefit supplement prior results that indicate a lack of improvement in surgical outcomes associated with use of preoperative MRI. In combination with other reports, the results of this analysis highlight the importance of exploring the benefit of preoperative MRI in patient-reported outcomes such as women ’s decision quality and confidence levels with decisions involving treatment choices. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Factors influencing survival among patients with HER2-positive metastatic breast cancer treated with trastuzumab
ConclusionOlder age, increased PLR, and ALP were identified as poor prognostic factors and ER positivity as a favorable prognostic factor for OS after adjusting for the presence of CNS metastasis and the presence of number of  ≥ 2 distant metastatic sites. Increased PLR was a poor prognostic factor for both OS and FFS, and warrants further investigation into its prognostic ability amongst patients with HER2-positive metastatic breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Use of adjuvant chemotherapy in hormone receptor-positive breast cancer patients with or without the 21-gene expression assay
AbstractPurposeWe assessed the use of chemotherapy in breast cancer patients to investigate the factors that changed trends in chemotherapy following the adoption of the 21-gene expression assay in tumor genomic profiling.MethodsOur study used 2033 patients from the National Cancer Center in Korea diagnosed with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer (tumor size of 0.5  cm or larger and 0–3 node metastases) from 2010 to 2015. We analyzed use of the 21-gene expression assay, changes in frequency of adjuvant chemotherapy use, and clinicopathological f...
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Association between lifestyle, menstrual/reproductive history, and histological factors and risk of breast cancer in women biopsied for benign breast disease
AbstractThe third category for extent of involution in Table  4 was published incorrectly in the original publication. The correct classification is ≥ 75% and the corrected Table 4 is given in the Correction article. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy
ConclusionsThe present machine-learned analysis showed that, even with a large set of parameters acquired from a large cohort, early identification of these patients is only partly successful. This indicates that more parameters are needed for accurate prediction of persisting pain. However, with the current parameters it is possible, with a certainty of almost 95%, to exclude the possibility of persistent pain developing in a woman being treated for breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 6, 2018 Category: Cancer & Oncology Source Type: research

The relationship between patient and tumor characteristics, patterns of breast cancer care, and 5-year survival among elderly women with incident breast cancer
AbstractPurposeTo examine the relationship between patient and tumor characteristics, patterns of breast cancer care, and 5-year survival among a population-based cohort of elderly women with incident breast cancer, with a special focus on identifying sources of socioeconomic (SES) disparities in outcomes.MethodsWe identified women with newly diagnosed breast cancer in 2006 –2009 from the Surveillance and Epidemiology End Result study linked with Medicare claims. A Classification and Regression Tree (CART) model was applied to 13 individual indicators of neoadjuvant and adjuvant breast cancer treatment, tumor charact...
Source: Breast Cancer Research and Treatment - June 5, 2018 Category: Cancer & Oncology Source Type: research

Validation of the Vectra XT three-dimensional imaging system for measuring breast volume and symmetry following oncological reconstruction
ConclusionThis first validation of breast volume and shape symmetry measurements using the Vectra XT 3D-SI system suggests that these measurements have the potential to assist in pre-operative planning and also as a measure of aesthetic outcome. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 5, 2018 Category: Cancer & Oncology Source Type: research

Including internal mammary lymph nodes in radiation therapy for synchronous bilateral breast cancer: an international survey of treatment technique and clinical priorities
ConclusionThe results of the survey indicate that the IMLN-inclusion for radiation therapy has not yet been comprehensively adopted. As well, no consensus on best practice for radiation therapy treatment techniques has been reached. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 5, 2018 Category: Cancer & Oncology Source Type: research

Comparison of tumor-infiltrating lymphocytes of breast cancer in core needle biopsies and resected specimens: a retrospective analysis
This study aimed to evaluate the concordance between the TIL scores of CNBs and resected specimens of breast cancer.MethodsA total of 220 matched pairs of CNBs and resected specimens of breast cancer were included. Stromal TILs were scored on slides stained with hematoxylin and eosin. Clinicopathologic parameters and the agreement of the TIL scores between CNBs and resected specimens were statistically analyzed.ResultsThe average TIL score was approximately 4.4% higher for the resected specimens than for the CNBs. When the tumors were divided into two groups according to a 60% TIL score cut-off (low and intermediate TIL vs...
Source: Breast Cancer Research and Treatment - June 5, 2018 Category: Cancer & Oncology Source Type: research

Extent of regional lymph node surgery and impact on outcomes in patients with early-stage breast cancer and limited axillary disease undergoing mastectomy
AbstractPurposeManagement of the axilla in patients with early-stage breast cancer (ESBC) has evolved. Recent trials support less extensive axillary surgery in patients undergoing mastectomy. We examine factors affecting regional lymph node (RLN) surgery and outcomes in patients with ESBC undergoing mastectomy.MethodsWomen with clinical T1/2 N0 M0 invasive BC who underwent mastectomy with 1 –2 positive nodes were selected from the National Cancer Database (2004–2015). Axillary surgery was defined by number of RLNs examined: 1–5 sentinel LN dissection (SLND), and ≥ 10 axillary LND (ALND). Binary ...
Source: Breast Cancer Research and Treatment - June 5, 2018 Category: Cancer & Oncology Source Type: research

Pre-operative stromal stiffness measured by shear wave elastography is independently associated with breast cancer-specific survival
AbstractIntroductionWith the increased use of neoadjuvant therapy for breast cancer, there is a need for pre-operative prediction of prognosis. We aimed to assess the prognostic value of tumour stiffness measured by ultrasound shear wave elastography (SWE).MethodsA consecutive cohort of patients with invasive breast cancer underwent breast ultrasound (US) including SWE. The following were recorded prospectively: US diameter, stiffness at SWE, presentation source, core biopsy grade, oestrogen receptor (ER) status and pre-operative nodal status. Breast cancer-specific survival (BCSS) was analysed with regard to US size and s...
Source: Breast Cancer Research and Treatment - June 1, 2018 Category: Cancer & Oncology Source Type: research

Associations of dietary intake and supplement use with post-therapy cognitive recovery in breast cancer survivors
ConclusionsOur results indicate that higher vegetable intake, tea drinking, and fish oil supplementation may help post-therapy cognitive recovery for cancer patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 9, 2018 Category: Cancer & Oncology Source Type: research

Treatment-induced early menopause and the protective role of gonadotropin-releasing hormone agonists during chemotherapy
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 9, 2018 Category: Cancer & Oncology Source Type: research