Comprehensive analysis of the homeobox family genes in breast cancer demonstrates their similar roles in cancer and development
ConclusionComprehensive analysis of the HOX family demonstrated their similar roles in cancer and development, and indicated that the strong interaction of HOX genes might be specific to malignancies, especially in the case of poor prognostic cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 18, 2021 Category: Cancer & Oncology Source Type: research

The RAD51D c.82G & gt;A (p.Val28Met) variant disrupts normal splicing and is associated with hereditary ovarian cancer
ConclusionsOur results indicate that theRAD51D c.82G>A (p.Val28Met) variant contributes to cancer predisposition through disruption of normal mRNA splicing. The identification of this variant in an individual affected with high-grade serous fallopian tube cancer suggests that theRAD51D variant may contribute to predisposition to the ovarian cancer in this family. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 16, 2021 Category: Cancer & Oncology Source Type: research

HDAC6 inhibition enhances the anti-tumor effect of eribulin through tubulin acetylation in triple-negative breast cancer cells
ConclusionsHDAC6 inhibition enhances the anti-tumor effect of eribulin through the acetylation of α-tubulin. This combination therapy could represent a novel therapeutic strategy for TNBC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 16, 2021 Category: Cancer & Oncology Source Type: research

Scalp cooling in breast cancer patients treated with docetaxel –cyclophosphamide: patient- and nurse-reported results
AbstractPurposeRecent evidence supports the efficacy of scalp cooling in preventing chemotherapy-induced alopecia in breast cancer treatments. However, efficacy largely varies between treatment regimens. The aim of this study was to explore the patient- and nurse-reported results of scalp cooling in terms of hair loss and need for a wig/head cover in patients with breast cancer treated with 3-weekly docetaxel 75  mg/m2– cyclophosphamide 600 mg/m2.MethodsWe studied nurse-reported efficacy as noted in the electronic patient files of 85 patients treated with docetaxel 75  mg/m2– cyclophosp...
Source: Breast Cancer Research and Treatment - January 16, 2021 Category: Cancer & Oncology Source Type: research

Double heterozygosity for TP53 and BRCA1 mutations: clinical implications in populations with founder mutations
ConclusionsThis family highlights the need to genotype both parents, especially in populations with founder mutations, when aBRCA1 mutation is detected in an offspring, regardless of family history. The combination of mutations in these two genes presents a challenge for PGD since both genes are located on chromosome 17. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 15, 2021 Category: Cancer & Oncology Source Type: research

Prospective evaluation of sexual health in breast cancer women during the first year of adjuvant hormonal treatment using a cancer patient's dedicated questionnaire: A glaring gap of communication between health professionals and patients
ConclusionThe analysis of sexual QoL of BC patients during the first year of hormonal treatment with a recently developed, cancer-dedicated, standardized tool pointed out the need for deeper communication between professionals and patients regarding sexual issues to fill the current gap in care of cancer patients and help patients with adequate intervention and support. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 15, 2021 Category: Cancer & Oncology Source Type: research

Concordance of the 21-gene assay between core needle biopsy and resection specimens in early breast cancer patients
ConclusionA modest- to- strong correlation of ER, PR, HER-2 and Ki-67 gene expression and RS between CNBs and resection specimens was observed in the present study. The 21-gene RS test could be reliably performed on CNBs. ER, PR and HER-2 status showed remarkable concordance between the IHC and RT-PCR analyses. The concordance between paired samples was high for the IHC ER, PR and Ki-67 results and low for HER-2. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 13, 2021 Category: Cancer & Oncology Source Type: research

Management of ipsilateral breast tumor recurrence following breast conservation surgery: a comparative study of re-conservation vs mastectomy
AbstractBackgroundBreast conservation therapy (BCT) is well established for the management of primary operable breast cancer, with oncologic outcomes comparable to those of mastectomy. It remains unclear whether re-conservation therapy (RCT) is suitable for those patients who develop ipsilateral breast tumor recurrence (IBTR), for whom mastectomy is generally recommended.MethodsWe identified women who underwent BCT for invasive or ductal carcinoma in situ and developed IBTR as a first event, comparing the pattern of subsequent events and survival for those treated by RCT versus mastectomy.ResultsOf 16,968 patents who had B...
Source: Breast Cancer Research and Treatment - January 12, 2021 Category: Cancer & Oncology Source Type: research

A prospective observational study of patient-reported functioning and quality of life in advanced and metastatic breast cancer utilizing a novel mobile application
ConclusionsPatients treated with palbociclib, on average, reported consistently low levels of pain and fatigue as well as good QOL and overall health that remained stable throughout the first 6  months of treatment regardless of episodes of neutropenia. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 11, 2021 Category: Cancer & Oncology Source Type: research

Myosteatosis evaluation using erector spinae and psoas muscles to predict adverse events during adjuvant chemotherapy for breast cancer
AbstractBackgroundMyosteatosis (intramuscular adiposity) is predictive of chemotherapy toxicity in women undergoing adjuvant chemotherapy for breast cancer (BC). We evaluated a novel, user-friendly and cost-effective technique utilizing a Picture Archiving and Communication Systems (PACS) tool that is readily available in the electronic medical record (EMR), using skeletal muscle density (SMD) to detect myosteatosis and then compared PACS results with those derived from widely used body composition software (SliceOMatic, QC, Canada).MethodsUsing retrospective data from a sample of women with early BC (Stage I-III) who had ...
Source: Breast Cancer Research and Treatment - January 10, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer risk after age 60 among   BRCA1 and  BRCA2 mutation carriers
ConclusionsFindings from this large prospective study indicate that the risk of developing breast cancer remains high after age 60 in bothBRCA1 andBRCA2 mutation carriers. These findings warrant further evaluation of the role of breast cancer screening in older mutation carriers. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 10, 2021 Category: Cancer & Oncology Source Type: research

Endocrine therapy and radiotherapy use among older women with hormone receptor-positive, clinically node-negative breast cancer
AbstractPurposeTo examine patterns of radiotherapy (RT) and endocrine therapy (ET) use, associations between RT omission and ET adherence, and associations among ET and RT use and disease recurrence in older women with early-stage, estrogen receptor-positive breast cancer.MethodsWomen age 65 and older diagnosed with hormone receptor-positive, clinically node-negative breast cancer between 2005 and 2018 and who did not undergo mastectomy were included. Multinomial logistic regression was used to examine the trends in practice patterns over time and by age. Kaplan –Meier estimates were used to estimate the probability ...
Source: Breast Cancer Research and Treatment - January 9, 2021 Category: Cancer & Oncology Source Type: research

Spindle and kinetochore ‑associated complex subunit 3 accelerates breast cancer cell proliferation and invasion through the regulation of Akt/Wnt/β-catenin signaling
ConclusionsSKA3 accelerates proliferation and invasion in breast cancer through the modulation of Akt/Wnt/ β-catenin signaling. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 9, 2021 Category: Cancer & Oncology Source Type: research

FOXA1 is a determinant of drug resistance in breast cancer cells
ConclusionTogether, these data suggest that FOXA1 plays a role in making tumors more aggressive. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 8, 2021 Category: Cancer & Oncology Source Type: research

Triple-negative and HER2-positive breast cancers found by mammography screening show excellent prognosis
ConclusionIn the 50 –69 age group, the majority of HER2 + and TN cancers can be found by a quality assured population-based mammography screening. Despite their generally aggressive behavior, after a median follow-up of 8 years, distant disease-free survival was over 90% of these cancers detected by screening. T he worst prognosis of these cancers was in women who did not participate in screening. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 8, 2021 Category: Cancer & Oncology Source Type: research

Comparison of the performance of four staging systems in determining the prognosis of breast cancer among women undergoing neoadjuvant chemotherapy
This study comprises a retrospective cohort study of female breast cancer patients diagnosed at the Brazilian National Cancer Institute, Brazil from January 2013 to December 2015. A descriptive analysis of patient characteristics was conducted, and Kaplan –Meier curves, a Cox proportional hazard analysis and Receiver Operating Characteristic (ROC) curves were developed according to the assessed staging system scores.ResultsA total of 803 patients were eligible for this study. Most were under 65  years old (88.0%), presented advanced tumors (clinical stage ≥ IIB 77.1%), with positive estrogen rec...
Source: Breast Cancer Research and Treatment - January 8, 2021 Category: Cancer & Oncology Source Type: research

Letter to the Editor regarding the publication titled “Axillary lymph node dissection in node-positive breast cancer: are ten nodes adequate and when is enough, enough?”
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 7, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Behavior of metastatic breast cancer according to subtype
In the original publication of the article, Table 1 was published incorrectly. The corrected Table 1 is given below: (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 7, 2021 Category: Cancer & Oncology Source Type: research

Long-term follow-up assessment of cardiac safety in SAFE-HEaRt, a clinical trial evaluating the use of HER2-targeted therapies in patients with breast cancer and compromised heart function
ConclusionsLong-term follow-up of the SAFE-HEaRt study continues to provide safety data of HER2-targeted therapy use in patients with compromised heart function. The late development of cardiac dysfunction is uncommon and continued multi-disciplinary oncologic and cardiac care of patients is vital for improved patient outcomes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 5, 2021 Category: Cancer & Oncology Source Type: research

Comparison of short-term surgical outcomes between men and women with breast cancer: a retrospective study using nationwide inpatient data in Japan
ConclusionsThe matched-pair cohort analyses revealed no significant differences in postoperative complications between men and women with breast cancer. However, men showed better outcomes than women in terms of 30-day readmission, duration of anesthesia, length of hospitalization, and total hospitalization costs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 5, 2021 Category: Cancer & Oncology Source Type: research

N -myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target
ConclusionsThese results support further evaluation of NMT immunohistochemistry for patient selection and clinical trials of NMT inhibition in breast cancer patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II
ConclusionsDifferences in risk factors for symptom-detected vs. screen-detected breast cancer were observed and most notably, use of combined and estrogen-only HT and a history of benign breast disease were associated with increased risk of symptomatic detected breast cancer.ImpactIf confirmed, these data suggest that such women may benefit from more intensive screening to facilitate early detection. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Predictors and outcomes in breast cancer patients who did or did not pursue fertility preservation
AbstractPurposeBreast cancer is the most common cancer in reproductive age women, and treatment can affect fertility; however, there is often concern regarding the safety of increased estradiol (E2) levels and potential delays in treatment with ovarian stimulation for fertility preservation (FP). The aim of this study was to compare recurrence and survival in breast cancer patients who pursued FP without concurrent letrozole to those who did not (non-FP).MethodsWe reviewed charts of women with breast cancer who contacted the FP patient navigator (PN) at Northwestern University from 01/2005 –01/2018. Oncology and fert...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Association between radiologists ’ and facilities’ characteristics and mammography screening detection of ductal carcinoma in situ
AbstractPurposeThe aim of our study was, first, to measure association between radiologists and facilities characteristics and DCIS detection. Second, to assess whether those characteristics affect differently the likelihood of detection of DCIS versus invasive breast cancer. When applicable, we examined whether the identified characteristics were similarly associated with low-grade and high-grade DCIS detection.MethodsThis retrospective cohort study included 1,750,002 digital screening mammograms (2145 screen-detected DCIS) performed in the Quebec breast cancer screening program between 2007 and 2015 inclusively. The asso...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

New brain metastases after whole-brain radiotherapy of initial brain metastases in breast cancer patients: the significance of molecular subtypes (KROG 16-12)
AbstractPurposeTo identify the risk factors leading to new brain metastases (BM) following brain-directed treatment for initial BM resulting from breast cancer (BC).MethodsIn this multi-institutional study, 538  BC patients with available follow-up imaging after brain-directed treatment for initial BM were analyzed. Tumor molecular subtypes were classified as follows: hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−,n = 136), HER2-positive (HER2+,n = 253), or triple-negative BC (TNBC,n = 149).ResultsIn 37.4% of patients, new BM emerg...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Is bioimpedance spectroscopy a useful tool for objectively assessing lymphovenous bypass surgical outcomes in breast cancer-related lymphedema?
ConclusionsThis is the first study to utilize BIS measurements to assess response to LVB surgical intervention for BCRL. BIS measurements demonstrated clinically significant improvement after LVB, providing objective evidence in support of this surgical treatment for BCRL. BIS changes should be reported as key objective data in future studies assessing BCRL interventions, including response to LVB. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Impact of xenobiotic-metabolizing gene polymorphisms on breast cancer risk in South Indian women
AbstractBackgroundFunctional variants of the xenobiotic-metabolizing genes (XMG) might modulate breast cancer (BC) risk by altering the rate of metabolism and clearance of myriad types of potent carcinogens from the breast tissue. Despite mounting evidence on the role of XMG variants on BC risk, the current knowledge regarding their influence on BC development is still fragmentary.MethodsThe present study examined the candidate genetic variants inCYP1A1,NQO1,GST-T1,GST-M1, andGST-P1 in 1002 subjects (502 BC patients and 500 disease-free women). PCR –RFLP was employed to genotype the mono-nucleotide variation inCYP1A1...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Association of mammographic density measures and breast cancer “intrinsic” molecular subtypes
AbstractPurposeWe evaluated the association of percent mammographic density (PMD), absolute dense area (DA), and non-dense area (NDA) with risk of “intrinsic” molecular breast cancer (BC) subtypes.MethodsWe pooled 3492 invasive BC and 10,148 controls across six studies with density measures from prediagnostic, digitized film-screen mammograms. We classified BC tumors into subtypes [63% Luminal A, 21% Luminal B, 5% HER2 expressing, and 11% as triple negative (TN)] using information on estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2  (HER2), and tumor grade. We us...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

The INTEND 1 randomized controlled trial of duct endoscopy as an indicator of margin excision in breast conservation surgery
ConclusionsThis randomized clinical trial was limited by incomplete accrual. DE did not contribute to improved margin excision rates whether a target lesion was visualized or not. The presence of EIC did not improve efficacy of DE. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Trends in neoadjuvant chemotherapy versus surgery-first in stage I HER2-positive breast cancer patients in the National Cancer DataBase (NCDB)
AbstractBackgroundNeoadjuvant chemotherapy (NAC) is the standard of care for locally advanced HER2  + breast cancer (BC). Optimal sequencing of treatment (NAC vs. surgery first) is less clear cut in stage I (T1N0) HER2 + BC, where information from surgical pathology could impact adjuvant treatment decisions. Utilizing the NCDB, we evaluated the trend of NAC use compared to upfront surgery in patients with small HER2 + BC.MethodsWe identified NCDB female patients diagnosed with T1 N0 HER2  + BC from 2010 through 2015. Prevalence ratios (PR) using multivariable robust P...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Cardiotoxicity during long-term trastuzumab use in patients with HER2-positive metastatic breast cancer: who needs cardiac monitoring?
ConclusionsSerial cardiac monitoring can be safely omitted in non-smoking patients with baseline LVEF  >  60% and without cardiotoxicity during prior neoadjuvant/adjuvant treatment. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Fatigue, anxiety, and quality of life in breast cancer patients compared to non-cancer controls: a nationwide longitudinal analysis
AbstractPurposeFatigue and anxiety are common and significant symptoms reported by cancer patients. Few studies have examined the trajectory of multidimensional fatigue and anxiety, the relationships between them and with quality of life.MethodsBreast cancer patients (n = 580) from community oncology clinics and age-matched controls (n = 364) completed fatigue and anxiety questionnaires prior to chemotherapy (A1), at chemotherapy completion (A2), and six months post-chemotherapy (A3). Linear mixed models (LMM) compared trajectories of fatigue /anxiety over time in patients and controls and estim...
Source: Breast Cancer Research and Treatment - January 4, 2021 Category: Cancer & Oncology Source Type: research

Safety and efficacy of abemaciclib plus endocrine therapy in older patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: an age-specific subgroup analysis of MONARCH 2 and 3 trials
AbstractPurposeAbemaciclib in combination with endocrine therapy (ET) has demonstrated significant efficacy benefits in HR+  , HER2− advanced breast cancer patients in the Phase 3 studies MONARCH 2 (fulvestrant as ET) and MONARCH 3 (letrozole or anastrozole as ET). Here, we report age-specific safety and efficacy outcomes.MethodsExploratory analyses of MONARCH 2 and 3 were performed for 3 age groups (
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Association between VEGF single nucleotide polymorphism and breast cancer in the Northern China Han population
ConclusionsIn the present study, we concluded that VEGF gene − 634G/C polymorphism is related to the incidence of breast cancer in the Han population in Northern China and also might be associated with tumor proliferation index Ki-67. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

BRCA testing and outcomes in women with breast cancer
ConclusionsThe proportion of women tested and the number ofBRCAm identified increased during the study period despite a decreasing proportion of positive results among women tested. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

A clinical calculator to predict disease outcomes in women with triple-negative breast cancer
AbstractPurposeTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by substantial risks of early disease recurrence and mortality. We constructed and validated clinical calculators for predicting recurrence-free survival (RFS) and overall survival (OS) for TNBC.MethodsData from 605 women with centrally confirmed TNBC who underwent primary breast cancer surgery at Mayo Clinic during 1985 –2012 were used to train risk models. Variables included age, menopausal status, tumor size, nodal status, Nottingham grade, surgery type, adjuvant radiation therapy, adjuvant chemothera...
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Is axillary imaging for invasive lobular carcinoma accurate in determining clinical node staging?
ConclusionA statistically significant difference between clinical and pathologic N-stage exists for ILC patients. MRI was most sensitive for identification of pN2-N3 patients and should be considered part of routine axillary imaging evaluation for ILC patients. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Prediction of axillary nodal burden in patients with invasive lobular carcinoma using MRI
ConclusionIn patients with ILC, MRI findings of suspicious LNs were helpful to predict a high nodal disease burden. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Residual risk stratification of Taiwanese breast cancers following curative therapies with the extended concurrent genes signature
DiscussionArchived FFPE samples could be successfully assayed by the NanoString nCounter. The purposed signature was prognostic stratifying breast cancer patients into groups with distinct survival patterns, and clinical applicability of the residual risk model was proved. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Identification of factors that influence the decision to take chemoprevention in patients with a significant family history of breast cancer: results from a patient questionnaire survey
ConclusionDespite its proven efficacy, chemoprevention uptake in patients with a significant FH of breast cancer remains low. We have identified important factors which influence the patient ’s decision making. Future clinic consultations should focus on exploring these factors to aid patient decision making. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

HER2 fluorescent in situ hybridization signal degradation: a 10-year retrospective study
ConclusionOur study is the first to demonstrate HER2 FISH signal degradation with time and slide storage conditions. Storing HER2 FISH slides in a –80 °C freezer allows for retention of both HER2 and CEP17 signals. At room temperature, the signals start to degrade with CEP17 signals lost at a faster rate. The results of the study may be used in official guidelines for storage conditions and retention time for HER2 FISH slides. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population?
AbstractIntroductionMetabolic syndrome (MS) is defined by having at least 3 of 4 components: obesity, dyslipidemia, hypertension (HTN), and diabetes. Prior studies analyzed the individual components of MS for all breast cancers which are predominantly hormone positive. Our study is the first to evaluate MS in triple-negative breast cancer (TNBC).MethodsA retrospective review of TNBC from 2007 to 2013 identified 177 patients with complete information for statistical analysis. Cox proportional hazards models were used to test the association between MS, disease-free survival (DFS), and overall survival (OS).Results48 (27%) p...
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

The prognostic significance of metastatic pattern in stage IV male breast cancer at initial diagnosis: a population-based study
AbstractPurposeMetastatic pattern (MP) is a prognostic factor in women with breast cancer. However, the prognostic significance of MP in male breast cancer patients remains unknown.MethodsUsing the SEER database, we gathered demographic information and disease characteristics for men diagnosed with de novo metastatic breast cancer from 2010 to 2017. Metastases to bone, brain, liver, and lung were used to define MP (bone-only, visceral, bone and visceral [BV], or other). Statistical analyses were performed to identify associations between overall survival (OS) and MP, as well as other patient and tumor features. We used mul...
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Cancer stem cell transcriptome landscape reveals biomarkers driving breast carcinoma heterogeneity
ConclusionsOur study contributes in identifying a CSC feature panel for breast carcinomas that drives breast carcinoma heterogeneity at the transcriptional level, which provides a reservoir for diagnostic marker and/or therapeutic target identification once experimentally validated as demonstrated byATP6V1B1. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Clinical significance of HER2 status in T1bN0 breast cancer: a nationwide study from the Korean Breast Cancer Society
ConclusionThis study analyzed a large nationwide and monoethnic cohort and found a significant difference only in BCSS in the ER-positive subgroup according to HER2 status. Anti-HER2 therapy may be considered in HER2-positive and ER-positive patients with small, node-negative breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells
ConclusionsOur study demonstrates an inverse correlation between PAI-1 and ESR1/PGR levels, as well as overall patient survival in estrogen/progesterone-responsive human tumours. With a focus on breast cancer, our data identify oleuropein as a natural PAI-1 inhibitor and suggest that oleuropein-mediated PAI-1 destabilisation may confer clinical benefit only in ER-/PR- tumours. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Treating (low-risk) DCIS patients: What can we learn from real-world cancer registry evidence?
ConclusionRWD from the SEER registry showed that women with primary DCIS and low-risk features demonstrate minimal differences by treatment strategy in experiencing subsequent breast events. There may be opportunity to de-escalate treatment for certain women with low-risk features: Hispanic and non-Hispanic white women aged 50 –69 at diagnosis, with ER+, grade 1 + 2,
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

Fourth-generation chimeric antigen receptor T cells targeting folate receptor alpha antigen expressed on breast cancer cells for adoptive T cell therapy
ConclusionThis proof-of-concept study thus shows the feasibility of using these fourth-generation FR α-CAR T cells for adoptive T cell therapy in BC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

CTCs-oriented adjuvant personalized cytostatic therapy non-metastatic breast cancer patients: continuous non-randomized prospective study and prospective randomized controlled study
ConclusionsThe use of the method of treatment of CTC-oriented personalized adjuvant therapy for non-metastatic breast cancer makes it possible to reliably increase DFS 5-year by 7.4% and OS 5-year by 11.6%. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 3, 2021 Category: Cancer & Oncology Source Type: research

ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes
ConclusionsIn breast cancer, highZNF703 copy number is associated with increased proliferation, Luminal B subtypes and poor prognosis. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 2, 2021 Category: Cancer & Oncology Source Type: research