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Impact of prior systemic therapy on lymphocytic infiltration in surgically resected breast cancer brain metastases
ConclusionsThis observation suggests that systemic therapy may interfere with the immune response to BCBMs and cause exhaustion of anti-tumor immunity. This motivates clinical investigation of strategies to enhance LI for therapeutic benefit to improve outcomes for patients with BCBMs. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 29, 2023 Category: Cancer & Oncology Source Type: research

Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort study
ConclusionIn this study, statin use was associated with a statistically significant decreased risk of breast cancer death, with subgroup analyses revealing a more protective effect in ER+ patients, postmenopausal women, and in women with advanced stage disease. Further research is warranted to determine if these associations are replicated in other clinical settings. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 29, 2023 Category: Cancer & Oncology Source Type: research

Advances in the prevention and treatment of breast cancer-related lymphedema
ConclusionProgress in prevention and treatment of BCRL continues, requiring advances in early diagnosis, patient education, expert consensus and novel treatments designed for lymphatic rehabilitation following insults. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 27, 2023 Category: Cancer & Oncology Source Type: research

Feasibility of introducing a smartphone navigation application into the care of breast cancer patients (The FIONA Study)
ConclusionIntroducing the Outcomes4Me patient navigation app into routine BC care is feasible and may improve the patient experience. These results support further evaluation of this mobile technology platform to improve BC education, symptom management, and decision making.Clinical trial registryClinicaltrials.gov registration #: NCT04262518 (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 27, 2023 Category: Cancer & Oncology Source Type: research

Use of imaging prediction model for omission of axillary surgery in early-stage breast cancer patients
ConclusionOur prediction model combining US and MRI characteristics of index cancer and LN lowered FNR compared to using US alone, and could potentially lead to avoid unnecessary SLNB in early stage, clinically node-negative breast cancers. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 25, 2023 Category: Cancer & Oncology Source Type: research

Differences in survivorship care experiences among older breast cancer survivors by clinical cancer characteristics, race/ethnicity, and socioeconomic factors: A SEER-CAHPS study
ConclusionThese study findings can be used to inform survivorship care providers treating women diagnosed with more advanced stage and aggressive disease. The disparities we observed among minority groups and by socioeconomic status should be further evaluated in future research as these interactions could impact long-term outcomes, including survival. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 24, 2023 Category: Cancer & Oncology Source Type: research

Subjective social status, race, and metabolic syndrome in women with breast cancer
ConclusionBlack women with breast cancer rank their SSS lower than White women with breast cancer do at each level of income and education. As SSS is strongly associated with MetS severity these results identify potentially modifiable factors that contribute to racial disparities. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 23, 2023 Category: Cancer & Oncology Source Type: research

The association between age at breast cancer diagnosis and prevalence of pathogenic variants
ConclusionsYoung age at BC diagnosis is not a strong risk factor for carrying PVs in BC-associated genesATM, CHEK2, orPALB2. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 21, 2023 Category: Cancer & Oncology Source Type: research

Identification of genetic and immune signatures for the recurrence of HER2-positive breast cancer after trastuzumab-based treatment
ConclusionsAberrant activation of multiple pathways and low baseline tumor-infiltrating B cells are related to HER2  + BC trastuzumab-based recurrence, which primarily affects the antitumor activity of trastuzumab. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 21, 2023 Category: Cancer & Oncology Source Type: research

Patient reported symptom burden amongst immigrant and Canadian long-term resident women undergoing breast cancer surgery
ConclusionsThis is the first study comparing symptom burden amongst immigrant and non-immigrant women with breast cancer at a population-level. Immigrant women with breast cancer undergoing surgery were found to have a higher burden of pain. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 21, 2023 Category: Cancer & Oncology Source Type: research

Correction to: Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF- β/SMAD signaling
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 20, 2023 Category: Cancer & Oncology Source Type: research

Should low-risk DCIS lose the cancer label? An evidence review
ConclusionEpidemiological evidence supports consideration of relabelling and/or recalibrating diagnostic thresholds for low-risk DCIS. Such diagnostic changes would need agreement on the definition of low-risk DCIS and improved diagnostic reproducibility. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 19, 2023 Category: Cancer & Oncology Source Type: research

Letter to the editor regarding the article “pregnancy-associated breast cancer: a multicenter study comparing clinicopathological factors, diagnosis, and treatment outcomes with non-pregnant patients”
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 19, 2023 Category: Cancer & Oncology Source Type: research

Association between gout and subsequent breast cancer: a retrospective cohort study including 67,598 primary care patients in Germany
ConclusionTaken together, the findings of our study provide evidence for the association between gout and subsequent breast cancer diagnosis, particularly in the youngest age group. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 18, 2023 Category: Cancer & Oncology Source Type: research

Malignant phyllodes tumors of the breast: the malignancy grading and associations with prognosis
ConclusionsHigher malignancy grade, presence of heterologous elements, younger age, larger tumor size, and recent rapid tumor growth are poor prognostic factors for MPTs of the breast. The malignancy grading system may be generalized in the future. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - April 18, 2023 Category: Cancer & Oncology Source Type: research