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Investigating potential immune mechanisms of trilaciclib administered prior to chemotherapy in patients with metastatic triple-negative breast cancer
ConclusionThe results suggest that administering trilaciclib prior to GCb may modulate the composition and response of immune cell subsets to TNBC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)
ConclusionSubstantial heterogeneity in the use of NST with HR+/HER2-breast cancer exists in Europe. While stringent guidelines are available for its use in triple-negative and HER2+  breast cancer, there is a need for the development of and adherence to well-defined recommendations for HR+/HER2-breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Preventative therapy for breast cancer: a clinical experience
ConclusionsWomen at increased risk of breast cancer accept additional screening but are reluctant to take preventative therapy. This suggests that stratified screening methods using risk calculations would have high uptake. Raising awareness of preventative therapy is important and the breast cancer community has yet to find the optimum timing and formula for discussing it and must accept women ’s informed preferences above artificial targets.Registration numbersThe PIONEER study was granted Health Research Authority (HRA) ethical approval by the Westminster Ethics Committee. IRAS project ID 265619, ClinicalTrials.gov Id...
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Racial disparities in treatment and outcomes between non-Hispanic Black and non-Hispanic White women with nonmetastatic inflammatory breast cancer
ConclusionAfter adjustment for demographic, clinicopathological, and socioeconomic factors; NHB women with IBC had similar odds of receiving surgery, chemotherapy, and radiation therapy, but were more likely to die of the disease compared to their NHW counterparts. Our findings suggest the presence of masked tumor biology, treatment, or socioeconomic factors associated with race that can lead to worse IBC outcomes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity
ConclusionHSD17B4 KO in BT-474 cells caused a decrease of PUFAs, increased Akt phosphorylation, enhanced glucose dependence of OxPhos, and increased sensitivity to inhibition of HER2, upstream of Akt. This mechanism may be applicable to other HER2-positive glucose-dependent breast cancer cells withHSD17B4 silencing. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Tamoxifen and the risk of breast cancer in women with a BRCA1 or BRCA2 mutation
ConclusionChemoprevention may be an effective risk-reduction option forBRCA mutation carriers, but further studies with longer follow-up are necessary. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia
ConclusionOur study confirms the associations of 21 SNPs (19/55 or 34.5% out of all known MD loci identified in women of European ancestry) with area and/or volumetric densities in Asian women, and further supports the evidence of a shared genetic basis through common genetic variants for MD and breast cancer risk. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Real-world data analysis of perioperative chemotherapy patterns, G-CSF use, and FN status in patients with early breast cancer
ConclusionDespite the increasing use of escalated regimens in the last 5 –6 years, FNH continuously declined, and the odds of FNH were lower among patients treated with pegfilgrastim PP. These results may suggest the contribution of PP in part to suppressing FNH levels over the last 5–6 years. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Intratumor spatial heterogeneity in programmed death-ligand 1 (PD-L1) protein expression in early-stage breast cancer
ConclusionThese results indicate that the overall 84% concordance is driven by concordant negative results. In PD-L1 positive cancers, within-tumor heterogeneity in PD-L1 expression exists. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Discordance of PIK3CA mutational status between primary and metastatic breast cancer: a systematic review and meta-analysis
ConclusionsOur results indicate the need of obtaining metastatic biopsies forPIK3CA-mutation analysis and the possibility of testing of the primary tumor, in case a re-biopsy deemed non-feasible. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3  + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
ConclusionIn the HER2  + Luminal B subgroup, high FoxP3 + TILs were associated with shorter DFS. A high CD8 + mTILs/CD68 + TAMs ratio seems to associate with impressive efficacy of trastuzumab. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Pathologic complete response of ductal carcinoma in situ to neoadjuvant systemic therapy in HER2-positive invasive breast cancer patients: a nationwide analysis
ConclusionPathologic complete response of DCIS occurred in 52.0% of HER2-positive IBC patients and was associated with ER-negative IBC and more recent years of diagnosis. Future studies should investigate imaging evaluation of DCIS response to improve surgical decision making. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Comparing quality of breast cancer care in the Netherlands and Norway by federated propensity score analytics
ConclusionBoth countries achieved high scores on the QIs. Differences were observed in the use of MRI and proportion of patients receiving single surgery. The federated approach supports future possibilities on benchmark QIs without transfer of privacy-sensitive data. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Randomized phase III trial of a neoadjuvant regimen of four cycles of adriamycin plus cyclophosphamide followed by four cycles of docetaxel (AC4-D4) versus a shorter treatment of three cycles of FEC followed by three cycles of docetaxel (FEC3-D3) in node-positive breast cancer (Neo-shorter; NCT02001506)
ConclusionSix cycles of FEC3-D3 could be an alternative to eight of AC4-D4. Trial registration ClinicalTrials.gov NCT02001506. Registered December 5,2013.https://clinicaltrials.gov/ct2/show/NCT02001506 (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research

Quantifying radiation in the axillary bed at the site of lymphedema surgical prevention
ConclusionOur findings suggest that even when the site of surgical prevention was not within the targeted radiation field during treatment planning, it remains susceptible to radiation. Strategies for limiting radiation at this site are needed. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research