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Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants
ConclusionAlmost allCHEK2-associated BCs were ER  + IDC-NST, with most classified as luminal B with or without HER2 overexpression. NGS supported the luminal-like phenotype and confirmedCHEK2 as an oncogenic driver in the majority of cases. Responses to neoadjuvant chemotherapy were variable but mostly incomplete. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 13, 2023 Category: Cancer & Oncology Source Type: research

Superparamagnetic iron oxide (SPIO) for axillary mapping in patients with ductal carcinoma in situ undergoing mastectomy: single-institution experience
ConclusionThe use of superparamagnetic iron oxide dye can prevent unnecessary axillary surgery in patients with DCIS undergoing mastectomy. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 12, 2023 Category: Cancer & Oncology Source Type: research

FTO is a major genetic link between breast cancer, obesity, and diabetes
ConclusionsThis study suggests that the FTO gene is one of the major genes shared by BC, T2DM, and obesity based on two DNA repair and inflammatory mechanisms. These results may provide a new perspective on the important role of the FTO gene and repair mechanism in the relationship between BC, obesity, and T2DM for future studies. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 9, 2023 Category: Cancer & Oncology Source Type: research

Patterns of chemotherapy receipt among patients with hormone receptor-positive, HER2-negative breast cancer
ConclusionsWhile race was not strongly associated with chemotherapy receipt, younger age remains a strong predictor of chemotherapy receipt, even with adjustment for clinical factors and among women who receive genomic testing. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 9, 2023 Category: Cancer & Oncology Source Type: research

Impact of HER2-low status for patients with early-stage breast cancer and non-pCR after neoadjuvant chemotherapy: a National Cancer Database Analysis
ConclusionIn both early-stage HR-positive and TNBC patients, HER2-low status was associated with lower pCR rates. HER2-zero status might be considered an adverse prognostic factor for OS in patients not achieving pCR. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 8, 2023 Category: Cancer & Oncology Source Type: research

Breast cancers in monoallelic MUTYH germline mutation carriers have clinicopathological features overlapping with those in BRCA1 germline mutation carriers
ConclusionAlthough germline monoallelicMUTYH mutation is not thought to confer a meaningfully increased risk of breast cancer development, it may contribute to pathological aggressiveness and diversity of breast cancers when they sporadically arise inMUTYH carriers. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Northern origin of the BRCA2 c.5286  T  & gt;  G founder allele
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Incidence and risk factors of hypothyroidism after treatment for early breast cancer: a population-based cohort study
ConclusionsBased on the results of our study, the implementation of hypothyroidism surveillance among the breast cancer survivors treated with radiotherapy of the regional lymph nodes can be considered as reasonable in the follow-up program. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Restoring microRNA-34a overcomes acquired drug resistance and disease progression in human breast cancer cell lines via suppressing the ABCC1 gene
ConclusionThe ectopic expression of miRNA-34a ameliorates the acquired drug resistance and the migration properties that may eventually lead to improved clinical strategies and outcomes for breast cancer patients. Additionally, miRNA-34a could be monitored as a diagnostic/prognostic biomarker for resistant conditions. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Randomized adaptive selection trial of cryotherapy, compression therapy, and placebo to prevent taxane-induced peripheral neuropathy in patients with breast cancer
ConclusionCompression therapy was the most effective intervention in this phase IIB selection trial to prevent CIPN and was well tolerated. Compression therapy for the prevention of CIPN should be evaluated in a phase III study.Clinical trial registrationClinicaTrials.gov Identifier: NCT03873272. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Association between prediabetes and breast cancer: a comprehensive meta-analysis
ConclusionsIn conclusion, individuals with prediabetes have higher risk of developing breast cancer than those with normoglycemia, especially younger prediabetes patients. These individuals may benefit from early identification, monitoring, and interventions to reverse prediabetes.Graphical abstract (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 7, 2023 Category: Cancer & Oncology Source Type: research

Presence of crown-like structures in breast adipose tissue; differences between healthy controls, BRCA1/2 gene mutation carriers and breast cancer patients
ConclusionIn conclusion, CLS were more frequently present in breast adipose tissue of breast cancer patients compared toBRCA1/2 gene mutation carriers and healthy controls. Furthermore, our study provides evidence of the association between obesity and presence of CLS. The prognostic significance and impact on clinical outcome of differences in CLS numbers should be further assessed in prospective studies. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 6, 2023 Category: Cancer & Oncology Source Type: research

The role of endocrine treatment on the risk of developing an ipsilateral invasive breast cancer in hormone receptor positive patients with ductal carcinoma in situ
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 5, 2023 Category: Cancer & Oncology Source Type: research

Association of clinicopathologic and molecular factors with the occurrence of positive margins in breast cancer
ConclusionThe occurrence of positive margins after surgery was associated with various clinical factors, similar to the findings reported in earlier studies. In addition, we found that the PAM50 intrinsic subtype Luminal A has more chance of obtaining positive margins compared to Basal type. As the first effort to pursue molecular understanding of the margin status, a gene panel of 29 genes including 17 protein-coding genes was also identified for potential prediction of the margin status which needs to be validated using a larger sample set. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 1, 2023 Category: Cancer & Oncology Source Type: research

A risk-based subgroup analysis of the effect of adjuvant S-1 in estrogen receptor-positive, HER2-negative early breast cancer
ConclusionsThe benefit of adding adjuvant S-1 was particularly marked in group 2. Further investigations are warranted to explore the optimal usage of adjuvant S-1. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - October 11, 2023 Category: Cancer & Oncology Source Type: research