HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity

ConclusionHSD17B4 KO in BT-474 cells caused a decrease of PUFAs, increased Akt phosphorylation, enhanced glucose dependence of OxPhos, and increased sensitivity to inhibition of HER2, upstream of Akt. This mechanism may be applicable to other HER2-positive glucose-dependent breast cancer cells withHSD17B4 silencing.

http://link.springer.com/10.1007/s10549-023-07013-y

Source: Breast Cancer Research and Treatment - July 22, 2023 Category: Cancer & Oncology Source Type: research