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The role of serum thymidine kinase 1 activity in neoadjuvant-treated HER2-positive breast cancer: biomarker analysis from the Swedish phase II randomized PREDIX HER2 trial
ConclusionsTK1 activity increased following neoadjuvant therapy for HER2-positive BC but was not associated with patient outcomes or treatment benefit. However, the post-surgery prognostic value in patients that have not attained pCR warrants further investigation.Trial registrationClinicalTrials.gov, NCT02568839. Registered on 6 October 2015. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 4, 2024 Category: Cancer & Oncology Source Type: research

Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach
ConclusionThe target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1 –4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Relationship between oily fish intake and breast cancer based on estrogen receptor status: a Mendelian randomization study
ConclusionThe oily fish intake has a negatively correlated with the incidence of total breast cancer, particularly in the cases of ER − breast cancer. There is a lack of substantial evidence supporting a link between the oily fish intake and the incidence of ER + breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Discordance of Oncotype DX scores in synchronous bilateral and unilateral multifocal breast cancers
ConclusionDiscordance of Oncotype RS is common in both bilateral and unilateral multifocal breast cancer and is likely associated with discordant histologic grade or Ki67. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Eribulin promotes proliferation of CD8+ T cells and potentiates T cell-mediated anti-tumor activity against triple-negative breast cancer cells
ConclusionsEribulin promoted CD8+T cell proliferation, repressed effectorT cell differentiation, and harnessedT cell-mediated anti-tumor effects. These mechanisms may be one of the cues that eribulin can improve the immunological status of tumor-bearing hosts. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Gene expression profiles in clinically T1-2N0 ER+HER2 − breast cancer patients treated with breast-conserving therapy: their added value in case sentinel lymph node biopsy is not performed
ConclusionIf no SLNB is performed, clinical risk status according to the guideline of 2020 and PREDICT predicts a very low risk for systemic undertreatment. The number of GEPs needed to identify one patient at risk for undertreatment does not justify its standard use. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Disparities with influenza vaccine use in long-term survivors of metastatic breast cancer
ConclusionOver 1/3 of long-term MBC survivors in our cohort did not receive the influenza vaccine. Black patients are about half as likely to be vaccinated. Given the known benefit of the vaccine, improving uptake could be an important strategy to improve outcomes. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Long-term outcome in patients with nodal-positive breast cancer treated with sentinel lymph node biopsy alone after neoadjuvant chemotherapy
ConclusionOur findings suggest that cN1 patients who were converted to ypN0 following NAC may be safely treated with SLNB only. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Differential response to neoadjuvant endocrine therapy for Black/African American and White women in NCDB
ConclusionIndependent of NET duration and clinical stage at presentation, BAA women were more likely to experience both complete tumor response and progression to metastatic disease. These results suggest significant heterogeneity in tumor biology and warrant a more nuanced therapeutic approach to HR  + BC. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Correlation between breast cancer subtypes determined by immunohistochemistry and n-COUNTER PAM50 assay: a real-world study
ConclusionThe concordance between luminal subtypes determined by three different IHC-based classifiers and the nCOUNTER PAM50 assay was suboptimal. Thus, a significant proportion of luminal A and B tumors as determined by the surrogate classifiers could be undertreated or over-treated. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Low incidence of distant metastases in older women with non-metastatic breast cancer treated with primary endocrine therapy
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Body mass index impacts adverse events and drug plasma concentration: should dose intensity be included in the palbociclib equation?
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Long-term breast cancer incidence trends by mammography, obesity, and menopausal hormone therapy
ConclusionThe sustained reduction in hormone therapy use from 2003 provides a plausible explanation for most of the lower breast cancer incidence seen in US postmenopausal women during the last two decades. The strong observational study obesity association with higher breast cancer risk is not reflected in breast cancer incidence trends. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Retraction Note: Glypican-3 regulates migration, adhesion and actin cytoskeleton organization in mammary tumor cells through Wnt signaling modulation
(Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 1, 2024 Category: Cancer & Oncology Source Type: research

Subspecialized breast pathologists have suboptimal interobserver agreement in Ki-67 evaluation using 20% as the cutoff
ConclusionThe modified IKWG algorithm does not significantly improve interobserver agreement. A better algorithm or assistance from digital image analysis is needed to improve interobserver variability in Ki-67 evaluation. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - December 29, 2023 Category: Cancer & Oncology Source Type: research