Patterns of Ventilation and Perfusion in the Early Post-Transplant Lung Allograft Using the Automatic Lung Parameter Estimator (ALPE)
This study assesses the utility of ALPE in understanding V/Q phenotypes post-transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: S. Dumschat, S. Kruszona, J. Salman, C. Falk, A. Ruhparwar, T. Welte, F. Ius, Source Type: research
Trajectory of Vasoactive-Inotropic Scores for Patients on Extracorporeal Membrane Oxygenation: A Linear Mixed Model Analysis
Purpose: Patients with shock often require manipulation of hemodynamic parameters to maintain end-organ perfusion. To equate amounts of vasoactive and inotropic medications that a patient receives, the vasopressor inotrope score (VIS) provides a reproducible index. Patients who, despite the addition of vasoactives, remain insufficiently supported, may be candidates for extracorporeal membrane oxygenation (ECMO). The primary purpose of this investigation was to identify peri-cannulation VIS trends. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S.P. Keller Source Type: research
Ex Vivo Lung Perfusion (EVLP): An Algorithm Proposal to Identify Acceptable Organs for Transplantation
Purpose: Due to organ shortage, EVLP has been increasingly used to assess extended-criteria donor lung and expand donor pool. Different protocols are used worldwide to perform the procedure; however, organ acceptance criteria, although mainly evaluating the ratio between arterial oxygen partial pressure and inspiratory fraction of oxygen (PaO2/FiO2), are still not clearly defined. We propose a decision-making algorithm to help grafts assessment (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , F. Madotto, A. Palleschi, L. Rosso, F. Valenza, G. Grasselli, A. Zanella Source Type: research
Itaconate Supplementation in Preservation Solution Leads to Lung Function Improvement After Extended Hypothermic Preservation
This study aims to explore ITA in a lung cell IRI model, select the best ITA variant, and evaluate adding ITA to the lung preservation solution in a large animal model of Ex Vivo Lung Perfusion (EVLP). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Wang, J. Yune, J. Montagne, G. Garza, T. Lima, K. Yamanashi, P. Oliveira, F. Gao, Y. Zhang, A. Ali, M. Liu, S. Keshavjee, M. Cypel Source Type: research
Lung-on-a-Chip: A Novel Tool for Modeling Lung Transplant Ischemia Reperfusion Injury
Purpose: Current in vitro models used to investigate lung transplant (LTx) cold storage (CS) ischemia reperfusion injury (IRI) use cell lines in static culture. While these models have informed our understanding of CS IRI, they lack multicellular complexity, and do not recapitulate the physiological impact of breathing and perfusion. Here we utilized a commercially available lung organoid chip to develop a novel CS IRI model for use as a tool to dissect mechanisms that contribute to injury post LTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Gill, A. Emtiazjoo, A. Sharma, C. Atkinson Source Type: research
A Model for Mouse Ex Vivo Lung Perfusion (EVLP) Followed by Orthotopic Lung Transplantation
Purpose: Ex vivo lung perfusion (EVLP) is a promising method to expand the pool of transplantable lungs and precondition grafts before lung transplantation (LTx). We previously showed that functional regulatory T cells could be delivered to rat and human lungs during EVLP. Further research in this area is hampered by the lack of a suitable mouse EVLP-to-LTx model, which would allow the application of genetic tools to study this approach. Here, we developed a mouse EVLP-to-LTx model for investigating the delivery of Tregs and other immunomodulatory therapeutics to donor lungs prior to LTx. (Source: The Journal of Heart and ...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Oliver, B. Joe, K.F. Bei, N. Yoshiyasu, M. Liu, T. Martinu, S. Keshavjee, S. Juvet Source Type: research
Transient Heat Stress Protects from Endothelial Injury During Prolonged Ex-Vivo Perfusion of Warm Ischemic Rat Lungs
Purpose:: Ex-vivo lung perfusion (EVLP) is a validated technique allowing evaluation and reconditioning of lung graft before transplantation (LTx). Moderate hyperthermia is recognized to induces cytoprotective effect, by increased production of specific proteins, well known as heat shock proteins (HSPs). We hypothesized that moderate heat stress applied during EVLP could improve lung graft function in a prolonged ex-vivo perfusion model via reduction of lung endothelial permeability and inflammation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Debonneville, J. Lugrin, M. Allouche, M. Gonzalez, J. Perentes, L. Liaudet, T. Krueger Source Type: research
Repair of Endothelial Glycocalyx Improves Lung Function During Human Ex Vivo Lung Perfusion
Purpose: Defects in endothelial glycocalyx associated with damaged vascular integrity can lead to lung dysfunction and graft rejection. Injection of circulating glycosaminoglycan components during ex vivo lung perfusion (EVLP) could provide an opportunity to repair and rebuild the endothelial glycocalyx, thus improving lung function prior to transplant. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Givens, L. Buie, L. Wade, S. Popa, B. Wannberg, J. Benjamin, T. Petersen Source Type: research
Assessment of the Effect of Temperature on Hemocompatibility and Organ Stability During Prolonged Ex Vivo Lung Perfusion - A Proof of Concept Study
Purpose: Ex-Vivo Lung Perfusion (EVLP) use is rapidly increasing due to its potential to improve donor lung utilization and organ quality, but the ideal conditions for prolonged out of body preservation are unclear. Using a blood-based perfusion model for 30 hours of swine lung preservation, we explored the effects of temperature on various hemocompatibility related-biomarkers and organ outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Farooqui, H. Al-Sahli, L. Chacon, A. Elsenousi, A. Matter, G. Loor, Y. Wang Source Type: research
The Effects of Different Perfusion Parameters on Cardiac Graft Behavior During Langendorff
Purpose: Cardiac research faces the challenge of stagnant whole organ ex vivo techniques and the absence of a consensus on optimal protocols. This research aims to elucidate the influence of varying parameters (Flow/Pressure, packed red blood cells - pRBCs) on perfusion outcomes. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Lopera Higuita, C.A. Pendexter, M. Mojoudi, A.A. Osho, S. Rabi, S.N. Tessier Source Type: research
Towards the Digital Lung: A Deep Learning Approach to Simulating Physiological Lung Function During Ex Vivo Lung Perfusion
Purpose: Ex vivo lung perfusion (EVLP) is an established reconditioning platform that generates multi-modal physiological data from isolated human lungs and is, thus, well-suited for machine learning. Digital twins —computer simulations of physical objects—are an emerging concept in medicine; however, they are unexplored in transplant medicine. Herein, we describe the development of a deep learning approach to simulate physiological lung function by leveraging high-resolution time-series lung ventilation d ata and demonstrate its predictive utility during EVLP. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Del Sorbo, O. Hough, T. Borrillo, M. Grubert Van Iderstine, B.T. Chao, L. Orsini, J. Valero, M. Cypel, B. Wang, S. Keshavjee, A.T. Sage Source Type: research
Effects of Organ Transport Distance in Lung Transplant with Ex Vivo Lung Perfusion
This study aimed to investigate the impact of organ transport distance on outcomes of lung transplant (LT) in EVLP vs. non-EVLP recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Jenkins, J. Ruck, A. Zhou, A. Rizaldi, A. Casillan, J. Ha, C. Merlo, E. Bush Source Type: research
5-Year Outcomes of the Organ Care System (OCS) Lung EXPAND Pivotal International Trial
This report evaluates the long-term (5-year) outcomes in the EXPAND cohort. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , F. Ius, D. Van Raemdonck, N. Langer, M. Smith, J. Kukreja, M. Hartwig, A. Ardehali, S. Huddleston Source Type: research
Assessment of Extended Criteria Donor Hearts with Resonance Raman Spectroscopy During Normothermic Machine Perfusion
Purpose: Normothermic Machine Perfusion (NMP) is an excellent method for the assessment of Extended Criteria Donor (ECD) organs, with the possibility of improving the supply of organs for heart transplantation. Resonance Raman Spectroscopy (RRS) is a real-time assessment technique, easily applied during NMP, that enables non-invasive quantification of the mitochondrial redox state and oxygen usage, as proxies for heart viability. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Lopera Higuita, M. Bolger-Chen, K.T. Nguyen, G. Olverson, G. Singh, D. Vincent, P. Romfh, S. Rabi, A. Osho, S.N. Tessier Source Type: research
Organ Care System Heart Perfusion (OHP) Registry Annual Report - DBD Heart Transplants Clinical Outcomes
Purpose: Organ Care System Heart Perfusion (OHP) registry was created to collect donor/recipient ’s characteristics and post-transplant outcomes for all OCS heart transplant cases in the real-world setting in the US. We are reporting early clinical outcomes from the DBD heart transplants cohort of the OHP registry. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , L. Klein, J. Schroder, G. Couper, S. Ohira, R. Davis, J. Haft, S. Pham, M. Daneshmand, D. Pham, D. D'Alessandro, B. Sun, D. Goldstein, D. Meyer, L. Lozonschi, R. Malyala, F. Esmailian, H. Mallidi, K. Takeda, P. Spencer, D. Kaczorowski, M. Funamoto, L. D Source Type: research
